Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.015 0.113 -9999.0 0.0 -0.298 18.0 18.0 epithelial cell differentiation 0.034 0.092 -9999.0 0.0 -0.267 12.0 12.0 CYFIP2 0.025 0.046 -9999.0 0.0 -0.506 1.0 1.0 ENAH -0.012 0.108 0.282 3.0 -0.328 6.0 9.0 EGFR -0.032 0.168 -9999.0 0.0 -0.506 17.0 17.0 EPHA2 -0.014 0.145 -9999.0 0.0 -0.506 12.0 12.0 MYO6 -0.009 0.092 -9999.0 0.0 -0.28 14.0 14.0 CTNNB1 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.051 -9999.0 0.0 -0.314 2.0 2.0 AQP5 -0.059 0.171 -9999.0 0.0 -0.482 19.0 19.0 CTNND1 0.015 0.096 -9999.0 0.0 -0.506 5.0 5.0 mol:PI-4-5-P2 -0.006 0.08 -9999.0 0.0 -0.254 13.0 13.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.103 -9999.0 0.0 -0.28 19.0 19.0 EGF -0.035 0.154 -9999.0 0.0 -0.506 14.0 14.0 NCKAP1 0.026 0.047 -9999.0 0.0 -0.506 1.0 1.0 AQP3 -0.098 0.194 -9999.0 0.0 -0.476 29.0 29.0 cortical microtubule organization 0.034 0.092 -9999.0 0.0 -0.267 12.0 12.0 GO:0000145 -0.025 0.071 -9999.0 0.0 -0.243 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.039 0.095 -9999.0 0.0 -0.269 12.0 12.0 MLLT4 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.054 0.11 -9999.0 0.0 -0.422 8.0 8.0 ARF6 0.024 0.062 -9999.0 0.0 -0.506 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.024 0.122 -9999.0 0.0 -0.352 12.0 12.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.018 0.07 -9999.0 0.0 -0.317 3.0 3.0 PVRL2 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.01 0.082 -9999.0 0.0 -0.256 14.0 14.0 ARF6/GTP 0.024 0.129 -9999.0 0.0 -0.342 13.0 13.0 CDH1 0.006 0.113 -9999.0 0.0 -0.506 7.0 7.0 EGFR/EGFR/EGF/EGF -0.043 0.154 -9999.0 0.0 -0.315 32.0 32.0 RhoA/GDP 0.036 0.089 -9999.0 0.0 -0.253 12.0 12.0 actin cytoskeleton organization -0.032 0.095 -9999.0 0.0 -0.32 11.0 11.0 IGF-1R heterotetramer -0.008 0.139 -9999.0 0.0 -0.506 11.0 11.0 GIT1 0.024 0.062 -9999.0 0.0 -0.506 2.0 2.0 IGF1R -0.008 0.139 -9999.0 0.0 -0.506 11.0 11.0 IGF1 -0.048 0.18 -9999.0 0.0 -0.506 20.0 20.0 DIAPH1 0.01 0.175 -9999.0 0.0 -0.657 4.0 4.0 Wnt receptor signaling pathway -0.034 0.092 0.267 12.0 -9999.0 0.0 12.0 RHOA 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.051 0.102 -9999.0 0.0 -0.413 7.0 7.0 CTNNA1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.033 0.097 -9999.0 0.0 -0.329 11.0 11.0 EFNA1 0.02 0.075 -9999.0 0.0 -0.506 3.0 3.0 LPP -0.022 0.062 -9999.0 0.0 -0.253 9.0 9.0 Ephrin A1/EPHA2 -0.0 0.128 -9999.0 0.0 -0.305 20.0 20.0 SEC6/SEC8 -0.005 0.064 -9999.0 0.0 -0.248 9.0 9.0 MGAT3 -0.025 0.104 -9999.0 0.0 -0.284 19.0 19.0 HGF/MET 0.02 0.093 -9999.0 0.0 -0.253 14.0 14.0 HGF 0.028 0.02 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.016 0.114 -9999.0 0.0 -0.301 18.0 18.0 actin cable formation 0.035 0.127 0.32 7.0 -0.319 2.0 9.0 KIAA1543 -0.023 0.07 -9999.0 0.0 -0.246 12.0 12.0 KIFC3 -0.003 0.076 -9999.0 0.0 -0.257 11.0 11.0 NCK1 0.02 0.062 -9999.0 0.0 -0.506 2.0 2.0 EXOC3 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.079 -9999.0 0.0 -0.26 12.0 12.0 NCK1/GIT1 0.027 0.068 -9999.0 0.0 -0.368 4.0 4.0 mol:GDP 0.034 0.092 -9999.0 0.0 -0.267 12.0 12.0 EXOC4 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.0 0.073 -9999.0 0.0 -0.257 10.0 10.0 PIP5K1C -0.006 0.081 -9999.0 0.0 -0.258 13.0 13.0 LIMA1 0.0 0.127 -9999.0 0.0 -0.506 9.0 9.0 ABI1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.01 0.129 0.295 5.0 -0.386 6.0 11.0 adherens junction assembly -0.013 0.099 -9999.0 0.0 -0.535 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.038 0.148 -9999.0 0.0 -0.286 36.0 36.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.044 0.019 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.02 0.075 -9999.0 0.0 -0.506 3.0 3.0 PLEKHA7 -0.004 0.078 -9999.0 0.0 -0.257 12.0 12.0 mol:GTP 0.022 0.12 -9999.0 0.0 -0.349 12.0 12.0 establishment of epithelial cell apical/basal polarity 0.015 0.108 0.369 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization -0.015 0.113 -9999.0 0.0 -0.298 18.0 18.0 regulation of cell-cell adhesion -0.032 0.095 -9999.0 0.0 -0.32 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.016 0.114 -9999.0 0.0 -0.301 18.0 18.0