Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.057 0.239 -9999.0 0.0 -0.771 21.0 21.0 IHH -0.058 0.154 -9999.0 0.0 -0.401 41.0 41.0 SHH Np/Cholesterol/GAS1 -0.063 0.164 -9999.0 0.0 -0.442 33.0 33.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.062 0.162 0.438 33.0 -9999.0 0.0 33.0 SMO/beta Arrestin2 -0.019 0.121 -9999.0 0.0 -0.538 4.0 4.0 SMO -0.027 0.127 -9999.0 0.0 -0.505 7.0 7.0 AKT1 0.004 0.064 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.007 0.096 -9999.0 0.0 -0.471 10.0 10.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.026 0.125 -9999.0 0.0 -0.498 7.0 7.0 STIL -0.062 0.158 -9999.0 0.0 -0.471 17.0 17.0 DHH N/PTCH2 -0.042 0.147 -9999.0 0.0 -0.379 39.0 39.0 DHH N/PTCH1 -0.035 0.142 -9999.0 0.0 -0.493 12.0 12.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.015 0.119 -9999.0 0.0 -0.544 12.0 12.0 PTHLH -0.052 0.249 -9999.0 0.0 -0.831 18.0 18.0 determination of left/right symmetry -0.026 0.125 -9999.0 0.0 -0.498 7.0 7.0 PIK3R1 0.008 0.035 -9999.0 0.0 -0.394 2.0 2.0 skeletal system development -0.051 0.244 -9999.0 0.0 -0.817 18.0 18.0 IHH N/Hhip -0.099 0.185 -9999.0 0.0 -0.41 56.0 56.0 DHH N/Hhip -0.072 0.178 -9999.0 0.0 -0.388 57.0 57.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.026 0.125 -9999.0 0.0 -0.498 7.0 7.0 pancreas development -0.086 0.209 -9999.0 0.0 -0.511 48.0 48.0 HHAT -0.016 0.133 -9999.0 0.0 -0.652 11.0 11.0 PI3K 0.015 0.025 -9999.0 0.0 -0.267 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.026 0.151 -9999.0 0.0 -0.634 15.0 15.0 somite specification -0.026 0.125 -9999.0 0.0 -0.498 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.067 0.161 -9999.0 0.0 -0.483 17.0 17.0 SHH Np/Cholesterol/PTCH2 -0.073 0.156 -9999.0 0.0 -0.393 41.0 41.0 SHH Np/Cholesterol/Megalin -0.193 0.196 -9999.0 0.0 -0.415 97.0 97.0 SHH -0.062 0.162 -9999.0 0.0 -0.359 54.0 54.0 catabolic process -0.029 0.137 -9999.0 0.0 -0.517 8.0 8.0 SMO/Vitamin D3 -0.058 0.159 -9999.0 0.0 -0.493 15.0 15.0 SHH Np/Cholesterol/Hhip -0.097 0.177 -9999.0 0.0 -0.426 46.0 46.0 LRP2 -0.258 0.285 -9999.0 0.0 -0.529 130.0 130.0 receptor-mediated endocytosis -0.152 0.184 -9999.0 0.0 -0.522 27.0 27.0 SHH Np/Cholesterol/BOC -0.052 0.139 -9999.0 0.0 -0.414 23.0 23.0 SHH Np/Cholesterol/CDO -0.046 0.14 -9999.0 0.0 -0.435 21.0 21.0 mesenchymal cell differentiation 0.096 0.176 0.423 46.0 -9999.0 0.0 46.0 mol:Vitamin D3 -0.065 0.162 -9999.0 0.0 -0.483 17.0 17.0 IHH N/PTCH2 -0.065 0.156 -9999.0 0.0 -0.396 38.0 38.0 CDON 0.003 0.068 -9999.0 0.0 -0.523 4.0 4.0 IHH N/PTCH1 -0.029 0.138 -9999.0 0.0 -0.522 8.0 8.0 Megalin/LRPAP1 -0.18 0.212 -9999.0 0.0 -0.379 130.0 130.0 PTCH2 -0.045 0.162 -9999.0 0.0 -0.48 30.0 30.0 SHH Np/Cholesterol -0.049 0.127 -9999.0 0.0 -0.277 54.0 54.0 PTCH1 -0.029 0.137 -9999.0 0.0 -0.519 8.0 8.0 HHIP -0.086 0.21 -9999.0 0.0 -0.512 48.0 48.0