Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.017 0.039 -9999.0 0.0 -0.233 4.0 4.0 epithelial cell differentiation 0.049 0.046 -9999.0 0.0 -0.262 4.0 4.0 CYFIP2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.011 0.05 0.27 1.0 -9999.0 0.0 1.0 EGFR 0.014 0.085 -9999.0 0.0 -0.492 7.0 7.0 EPHA2 0.026 0.033 -9999.0 0.0 -0.492 1.0 1.0 MYO6 -0.017 0.046 0.176 1.0 -0.313 5.0 6.0 CTNNB1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.054 0.016 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.048 0.156 -9999.0 0.0 -0.471 29.0 29.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.015 0.033 0.175 1.0 -0.25 4.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.034 0.073 0.175 1.0 -0.255 24.0 25.0 EGF -0.011 0.125 -9999.0 0.0 -0.492 16.0 16.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.015 0.096 -9999.0 0.0 -0.423 10.0 10.0 cortical microtubule organization 0.049 0.046 -9999.0 0.0 -0.262 4.0 4.0 GO:0000145 -0.015 0.031 0.161 1.0 -0.239 4.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.054 0.048 -9999.0 0.0 -0.264 4.0 4.0 MLLT4 0.025 0.033 -9999.0 0.0 -0.492 1.0 1.0 ARF6/GDP -0.024 0.029 -9999.0 0.0 -0.235 4.0 4.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.035 -9999.0 0.0 -0.281 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.03 -9999.0 0.0 -0.237 3.0 3.0 PVRL2 0.025 0.033 -9999.0 0.0 -0.492 1.0 1.0 ZYX -0.015 0.034 0.176 1.0 -0.254 4.0 5.0 ARF6/GTP 0.067 0.037 -9999.0 0.0 -0.264 1.0 1.0 CDH1 0.018 0.065 -9999.0 0.0 -0.492 4.0 4.0 EGFR/EGFR/EGF/EGF 0.015 0.093 -9999.0 0.0 -0.253 26.0 26.0 RhoA/GDP 0.05 0.045 -9999.0 0.0 -0.251 4.0 4.0 actin cytoskeleton organization -0.02 0.047 0.163 1.0 -0.307 6.0 7.0 IGF-1R heterotetramer 0.007 0.1 -9999.0 0.0 -0.491 10.0 10.0 GIT1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.007 0.1 -9999.0 0.0 -0.492 10.0 10.0 IGF1 0.011 0.09 -9999.0 0.0 -0.492 8.0 8.0 DIAPH1 0.044 0.096 -9999.0 0.0 -0.54 3.0 3.0 Wnt receptor signaling pathway -0.049 0.046 0.262 4.0 -9999.0 0.0 4.0 RHOA 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.024 0.029 -9999.0 0.0 -0.237 4.0 4.0 CTNNA1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.048 0.164 1.0 -0.314 6.0 7.0 EFNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.015 0.029 0.167 1.0 -0.24 3.0 4.0 Ephrin A1/EPHA2 0.04 0.045 -9999.0 0.0 -0.249 4.0 4.0 SEC6/SEC8 -0.022 0.037 -9999.0 0.0 -0.251 6.0 6.0 MGAT3 -0.034 0.074 0.176 1.0 -0.259 24.0 25.0 HGF/MET 0.007 0.107 -9999.0 0.0 -0.262 33.0 33.0 HGF 0.002 0.11 -9999.0 0.0 -0.492 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.017 0.039 -9999.0 0.0 -0.235 4.0 4.0 actin cable formation 0.029 0.072 0.244 12.0 -9999.0 0.0 12.0 KIAA1543 -0.018 0.039 -9999.0 0.0 -0.253 6.0 6.0 KIFC3 -0.016 0.033 0.176 1.0 -0.254 4.0 5.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.016 0.033 0.176 1.0 -0.25 4.0 5.0 NCK1/GIT1 0.039 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.049 0.046 -9999.0 0.0 -0.262 4.0 4.0 EXOC4 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.016 0.034 0.176 1.0 -0.254 4.0 5.0 PIP5K1C -0.015 0.034 0.176 1.0 -0.254 4.0 5.0 LIMA1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.008 0.06 0.291 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.032 0.117 -9999.0 0.0 -0.691 6.0 6.0 IGF-1R heterotetramer/IGF1 0.02 0.089 -9999.0 0.0 -0.265 21.0 21.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.039 -9999.0 0.0 -0.357 2.0 2.0 MET -0.013 0.139 -9999.0 0.0 -0.492 20.0 20.0 PLEKHA7 -0.018 0.041 -9999.0 0.0 -0.265 6.0 6.0 mol:GTP 0.059 0.034 -9999.0 0.0 -0.279 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.011 0.09 0.32 6.0 -0.291 1.0 7.0 cortical actin cytoskeleton stabilization 0.017 0.039 -9999.0 0.0 -0.233 4.0 4.0 regulation of cell-cell adhesion -0.02 0.047 0.163 1.0 -0.307 6.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.017 0.039 -9999.0 0.0 -0.235 4.0 4.0