E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.013 0.073 -9999.0 0.0 -0.402 18.0 18.0 KLHL20 -0.044 0.077 0.323 1.0 -0.29 9.0 10.0 CYFIP2 -0.001 0.051 -9999.0 0.0 -0.385 10.0 10.0 Rac1/GDP -0.015 0.05 -9999.0 0.0 -0.253 19.0 19.0 ENAH -0.014 0.074 -9999.0 0.0 -0.412 17.0 17.0 AP1M1 0.007 0.016 0.222 3.0 -9999.0 0.0 3.0 RAP1B 0.007 0.026 0.222 5.0 -0.385 1.0 6.0 RAP1A 0.007 0.009 0.222 1.0 -9999.0 0.0 1.0 CTNNB1 0.006 0.009 0.222 1.0 -9999.0 0.0 1.0 CDC42/GTP -0.018 0.035 -9999.0 0.0 -0.214 6.0 6.0 ABI1/Sra1/Nap1 -0.035 0.051 -9999.0 0.0 -0.153 21.0 21.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.008 0.045 -9999.0 0.0 -0.214 21.0 21.0 RAPGEF1 -0.016 0.064 -9999.0 0.0 -0.364 17.0 17.0 CTNND1 0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.011 0.075 -9999.0 0.0 -0.403 19.0 19.0 CRK -0.015 0.069 -9999.0 0.0 -0.39 17.0 17.0 E-cadherin/gamma catenin/alpha catenin -0.002 0.06 -9999.0 0.0 -0.246 31.0 31.0 alphaE/beta7 Integrin 0.007 0.026 -9999.0 0.0 -0.27 5.0 5.0 IQGAP1 0.005 0.025 0.222 1.0 -0.385 2.0 3.0 NCKAP1 0.01 0.028 0.222 10.0 -9999.0 0.0 10.0 Rap1/GTP/I-afadin 0.006 0.041 0.14 6.0 -0.204 19.0 25.0 DLG1 -0.003 0.082 -9999.0 0.0 -0.393 19.0 19.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.023 0.04 -9999.0 0.0 -0.17 10.0 10.0 MLLT4 -0.006 0.068 -9999.0 0.0 -0.385 18.0 18.0 ARF6/GTP/NME1/Tiam1 0.018 0.033 0.14 33.0 -0.204 2.0 35.0 PI3K -0.029 0.05 -9999.0 0.0 -0.217 10.0 10.0 ARF6 0.005 0.016 -9999.0 0.0 -0.385 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.006 0.068 -9999.0 0.0 -0.293 29.0 29.0 TIAM1 0.006 0.021 0.222 2.0 -0.385 1.0 3.0 E-cadherin(dimer)/Ca2+ 0.007 0.037 -9999.0 0.0 -0.192 19.0 19.0 AKT1 -0.018 0.031 -9999.0 0.0 -0.147 4.0 4.0 PIK3R1 -0.038 0.124 -9999.0 0.0 -0.385 64.0 64.0 CDH1 -0.006 0.067 -9999.0 0.0 -0.385 17.0 17.0 RhoA/GDP -0.013 0.05 -9999.0 0.0 -0.251 19.0 19.0 actin cytoskeleton organization -0.032 0.058 0.274 1.0 -0.224 7.0 8.0 CDC42/GDP -0.012 0.049 -9999.0 0.0 -0.251 19.0 19.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.009 0.054 -9999.0 0.0 -0.227 31.0 31.0 ITGB7 0.003 0.038 0.222 1.0 -0.385 5.0 6.0 RAC1 0.005 0.016 -9999.0 0.0 -0.385 1.0 1.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.008 0.04 -9999.0 0.0 -0.205 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.004 0.037 0.131 1.0 -0.191 19.0 20.0 mol:GDP -0.016 0.055 -9999.0 0.0 -0.288 19.0 19.0 CDC42/GTP/IQGAP1 0.008 0.014 -9999.0 0.0 -0.225 2.0 2.0 JUP -0.004 0.063 -9999.0 0.0 -0.385 15.0 15.0 p120 catenin/RhoA/GDP -0.012 0.051 -9999.0 0.0 -0.257 18.0 18.0 RAC1/GTP/IQGAP1 0.007 0.017 -9999.0 0.0 -0.225 3.0 3.0 PIP5K1C/AP1M1 0.009 0.001 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.005 0.023 -9999.0 0.0 -0.385 2.0 2.0 CDC42 0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.005 0.023 -9999.0 0.0 -0.385 2.0 2.0 positive regulation of S phase of mitotic cell cycle -0.046 0.081 0.368 1.0 -0.181 144.0 145.0 NME1 0.018 0.049 0.222 31.0 -9999.0 0.0 31.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.013 0.073 -9999.0 0.0 -0.412 17.0 17.0 regulation of cell-cell adhesion -0.016 0.031 -9999.0 0.0 -0.189 6.0 6.0 WASF2 -0.038 0.045 -9999.0 0.0 -0.134 47.0 47.0 Rap1/GTP -0.017 0.041 -9999.0 0.0 -0.238 6.0 6.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.004 0.058 -9999.0 0.0 -0.214 35.0 35.0 CCND1 -0.057 0.1 0.409 1.0 -0.223 145.0 146.0 VAV2 -0.019 0.088 -9999.0 0.0 -0.447 20.0 20.0 RAP1/GDP -0.011 0.046 -9999.0 0.0 -0.22 18.0 18.0 adherens junction assembly -0.013 0.071 -9999.0 0.0 -0.399 17.0 17.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.007 0.009 0.222 1.0 -9999.0 0.0 1.0 PIP5K1C 0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.0 0.055 -9999.0 0.0 -0.263 9.0 9.0 E-cadherin/beta catenin -0.006 0.051 -9999.0 0.0 -0.293 17.0 17.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.014 0.073 -9999.0 0.0 -0.394 19.0 19.0 PIK3CA 0.056 0.091 0.222 131.0 -9999.0 0.0 131.0 Rac1/GTP -0.068 0.12 0.416 1.0 -0.373 20.0 21.0 E-cadherin/beta catenin/alpha catenin 0.004 0.043 -9999.0 0.0 -0.227 19.0 19.0 ITGAE 0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.012 0.076 -9999.0 0.0 -0.412 19.0 19.0