Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.085 0.209 0.465 117.0 -0.47 15.0 132.0 IHH 0.023 0.074 -9999.0 0.0 -0.423 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.016 0.066 -9999.0 0.0 -0.21 57.0 57.0 LRPAP1 0.006 0.028 0.222 3.0 -0.385 2.0 5.0 dorsoventral neural tube patterning 0.016 0.065 0.209 57.0 -9999.0 0.0 57.0 SMO/beta Arrestin2 0.039 0.126 -9999.0 0.0 -0.498 10.0 10.0 SMO 0.04 0.137 -9999.0 0.0 -0.521 10.0 10.0 AKT1 0.023 0.119 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.033 0.119 0.222 1.0 -0.385 58.0 59.0 ADRBK1 0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.04 0.136 -9999.0 0.0 -0.513 10.0 10.0 STIL 0.13 0.128 0.324 116.0 -9999.0 0.0 116.0 DHH N/PTCH2 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.005 0.066 -9999.0 0.0 -0.368 15.0 15.0 PIK3CA 0.056 0.091 0.222 131.0 -9999.0 0.0 131.0 DHH 0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.074 0.2 -9999.0 0.0 -0.506 15.0 15.0 determination of left/right symmetry 0.04 0.136 -9999.0 0.0 -0.513 10.0 10.0 PIK3R1 -0.038 0.124 -9999.0 0.0 -0.385 64.0 64.0 skeletal system development 0.074 0.199 -9999.0 0.0 -0.503 15.0 15.0 IHH N/Hhip 0.02 0.045 0.245 1.0 -0.243 6.0 7.0 DHH N/Hhip 0.009 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.04 0.136 -9999.0 0.0 -0.513 10.0 10.0 pancreas development 0.008 0.02 0.222 5.0 -9999.0 0.0 5.0 HHAT 0.001 0.046 -9999.0 0.0 -0.385 8.0 8.0 PI3K -0.022 0.083 -9999.0 0.0 -0.27 56.0 56.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.029 0.112 -9999.0 0.0 -0.385 51.0 51.0 somite specification 0.04 0.136 -9999.0 0.0 -0.513 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.008 0.062 -9999.0 0.0 -0.379 10.0 10.0 SHH Np/Cholesterol/PTCH2 0.003 0.025 -9999.0 0.0 -0.203 8.0 8.0 SHH Np/Cholesterol/Megalin 0.038 0.065 0.141 148.0 -0.203 6.0 154.0 SHH -0.007 0.032 0.198 1.0 -0.27 8.0 9.0 catabolic process 0.055 0.15 0.312 117.0 -0.411 15.0 132.0 SMO/Vitamin D3 0.038 0.125 -9999.0 0.0 -0.462 10.0 10.0 SHH Np/Cholesterol/Hhip 0.004 0.028 0.141 5.0 -0.203 8.0 13.0 LRP2 0.063 0.095 0.222 151.0 -9999.0 0.0 151.0 receptor-mediated endocytosis 0.038 0.129 0.317 28.0 -0.47 10.0 38.0 SHH Np/Cholesterol/BOC -0.018 0.068 0.141 1.0 -0.207 65.0 66.0 SHH Np/Cholesterol/CDO 0.005 0.034 0.141 12.0 -0.203 10.0 22.0 mesenchymal cell differentiation -0.004 0.028 0.202 8.0 -0.139 5.0 13.0 mol:Vitamin D3 0.041 0.119 0.243 115.0 -0.38 10.0 125.0 IHH N/PTCH2 0.02 0.046 -9999.0 0.0 -0.243 7.0 7.0 CDON 0.009 0.039 0.222 12.0 -0.385 2.0 14.0 IHH N/PTCH1 0.054 0.141 0.29 117.0 -0.413 15.0 132.0 Megalin/LRPAP1 0.006 0.017 -9999.0 0.0 -0.27 2.0 2.0 PTCH2 0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.0 0.024 -9999.0 0.0 -0.203 8.0 8.0 PTCH1 0.055 0.15 0.313 117.0 -0.412 15.0 132.0 HHIP 0.008 0.02 0.222 5.0 -9999.0 0.0 5.0