Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.016 0.065 -9999.0 0.0 -0.211 56.0 56.0 epithelial cell differentiation 0.007 0.037 -9999.0 0.0 -0.19 19.0 19.0 CYFIP2 -0.001 0.051 -9999.0 0.0 -0.385 10.0 10.0 ENAH -0.001 0.044 0.187 4.0 -9999.0 0.0 4.0 EGFR -0.03 0.115 0.222 1.0 -0.385 54.0 55.0 EPHA2 0.007 0.009 0.222 1.0 -9999.0 0.0 1.0 MYO6 -0.011 0.042 -9999.0 0.0 -0.191 23.0 23.0 CTNNB1 0.007 0.009 0.222 1.0 -9999.0 0.0 1.0 ABI1/Sra1/Nap1 0.008 0.031 -9999.0 0.0 -0.227 10.0 10.0 AQP5 0.029 0.067 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.012 0.032 -9999.0 0.0 -0.181 19.0 19.0 regulation of calcium-dependent cell-cell adhesion -0.014 0.038 -9999.0 0.0 -0.181 27.0 27.0 EGF 0.009 0.024 0.222 7.0 -9999.0 0.0 7.0 NCKAP1 0.01 0.028 0.222 10.0 -9999.0 0.0 10.0 AQP3 -0.136 0.191 -9999.0 0.0 -0.417 176.0 176.0 cortical microtubule organization 0.007 0.037 -9999.0 0.0 -0.19 19.0 19.0 GO:0000145 -0.011 0.03 -9999.0 0.0 -0.173 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.008 0.038 -9999.0 0.0 -0.192 19.0 19.0 MLLT4 -0.006 0.068 -9999.0 0.0 -0.385 18.0 18.0 ARF6/GDP -0.013 0.028 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.006 0.016 -9999.0 0.0 -0.385 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.032 0.042 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.048 0.096 -9999.0 0.0 -0.246 84.0 84.0 PVRL2 0.006 0.019 0.222 1.0 -0.385 1.0 2.0 ZYX -0.038 0.071 -9999.0 0.0 -0.19 99.0 99.0 ARF6/GTP 0.031 0.038 -9999.0 0.0 -0.193 1.0 1.0 CDH1 -0.005 0.067 -9999.0 0.0 -0.385 17.0 17.0 EGFR/EGFR/EGF/EGF -0.013 0.066 -9999.0 0.0 -0.187 70.0 70.0 RhoA/GDP 0.006 0.037 -9999.0 0.0 -0.182 21.0 21.0 actin cytoskeleton organization -0.01 0.042 -9999.0 0.0 -0.191 19.0 19.0 IGF-1R heterotetramer -0.077 0.16 -9999.0 0.0 -0.385 121.0 121.0 GIT1 0.007 0.009 0.222 1.0 -9999.0 0.0 1.0 IGF1R -0.077 0.16 -9999.0 0.0 -0.385 121.0 121.0 IGF1 -0.003 0.067 0.222 4.0 -0.385 16.0 20.0 DIAPH1 0.002 0.08 -9999.0 0.0 -0.547 11.0 11.0 Wnt receptor signaling pathway -0.007 0.037 0.19 19.0 -9999.0 0.0 19.0 RHOA 0.005 0.023 -9999.0 0.0 -0.385 2.0 2.0 RhoA/GTP -0.014 0.029 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.005 0.023 -9999.0 0.0 -0.385 2.0 2.0 VCL -0.011 0.042 -9999.0 0.0 -0.195 19.0 19.0 EFNA1 0.017 0.047 0.222 28.0 -9999.0 0.0 28.0 LPP -0.022 0.053 -9999.0 0.0 -0.189 48.0 48.0 Ephrin A1/EPHA2 0.005 0.033 -9999.0 0.0 -0.178 17.0 17.0 SEC6/SEC8 -0.019 0.043 -9999.0 0.0 -0.33 3.0 3.0 MGAT3 -0.014 0.038 -9999.0 0.0 -0.184 27.0 27.0 HGF/MET -0.01 0.064 -9999.0 0.0 -0.194 58.0 58.0 HGF 0.008 0.018 0.222 4.0 -9999.0 0.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.016 0.066 -9999.0 0.0 -0.213 56.0 56.0 actin cable formation -0.02 0.066 0.165 4.0 -0.229 16.0 20.0 KIAA1543 -0.013 0.037 -9999.0 0.0 -0.194 19.0 19.0 KIFC3 -0.012 0.032 -9999.0 0.0 -0.183 19.0 19.0 NCK1 0.024 0.059 0.222 47.0 -9999.0 0.0 47.0 EXOC3 0.007 0.009 0.222 1.0 -9999.0 0.0 1.0 ACTN1 -0.015 0.043 -9999.0 0.0 -0.196 29.0 29.0 NCK1/GIT1 0.009 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.007 0.037 -9999.0 0.0 -0.19 19.0 19.0 EXOC4 0.009 0.024 0.222 7.0 -9999.0 0.0 7.0 STX4 -0.012 0.032 -9999.0 0.0 -0.183 19.0 19.0 PIP5K1C -0.012 0.032 -9999.0 0.0 -0.183 19.0 19.0 LIMA1 -0.02 0.098 -9999.0 0.0 -0.385 38.0 38.0 ABI1 0.007 0.009 0.222 1.0 -9999.0 0.0 1.0 ROCK1 -0.001 0.047 0.198 4.0 -9999.0 0.0 4.0 adherens junction assembly -0.008 0.039 -9999.0 0.0 -0.625 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.04 0.088 -9999.0 0.0 -0.185 150.0 150.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.05 -9999.0 0.0 -0.27 19.0 19.0 MET -0.013 0.12 0.222 32.0 -0.385 45.0 77.0 PLEKHA7 -0.012 0.035 -9999.0 0.0 -0.192 19.0 19.0 mol:GTP 0.031 0.041 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.018 0.044 -9999.0 0.0 -0.32 3.0 3.0 cortical actin cytoskeleton stabilization -0.016 0.065 -9999.0 0.0 -0.211 56.0 56.0 regulation of cell-cell adhesion -0.01 0.042 -9999.0 0.0 -0.191 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.016 0.066 -9999.0 0.0 -0.213 56.0 56.0