E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.037 0.107 -9999.0 0.0 -0.324 64.0 64.0 KLHL20 -0.055 0.083 0.509 1.0 -0.274 17.0 18.0 CYFIP2 0.026 0.038 -9999.0 0.0 -0.283 8.0 8.0 Rac1/GDP -0.042 0.08 0.24 5.0 -0.257 16.0 21.0 ENAH -0.038 0.107 -9999.0 0.0 -0.322 66.0 66.0 AP1M1 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.03 0.015 -9999.0 0.0 -0.283 1.0 1.0 RAP1A 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.031 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.054 0.051 0.121 25.0 -0.265 1.0 26.0 ABI1/Sra1/Nap1 -0.051 0.047 -9999.0 0.0 -0.17 33.0 33.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.058 0.054 -9999.0 0.0 -0.169 13.0 13.0 RAPGEF1 -0.043 0.1 0.241 4.0 -0.307 55.0 59.0 CTNND1 0.031 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.02 0.116 -9999.0 0.0 -0.324 68.0 68.0 CRK -0.043 0.103 -9999.0 0.0 -0.317 61.0 61.0 E-cadherin/gamma catenin/alpha catenin 0.045 0.054 -9999.0 0.0 -0.198 21.0 21.0 alphaE/beta7 Integrin 0.042 0.026 -9999.0 0.0 -0.203 5.0 5.0 IQGAP1 0.029 0.02 -9999.0 0.0 -0.283 2.0 2.0 NCKAP1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.045 0.041 -9999.0 0.0 -0.16 13.0 13.0 DLG1 -0.026 0.105 -9999.0 0.0 -0.324 54.0 54.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.04 0.04 -9999.0 0.0 -0.166 7.0 7.0 MLLT4 0.022 0.046 -9999.0 0.0 -0.283 12.0 12.0 ARF6/GTP/NME1/Tiam1 0.051 0.026 -9999.0 0.0 -0.16 1.0 1.0 PI3K -0.05 0.05 -9999.0 0.0 -0.211 7.0 7.0 ARF6 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.031 0.053 -9999.0 0.0 -0.226 20.0 20.0 TIAM1 0.03 0.014 -9999.0 0.0 -0.283 1.0 1.0 E-cadherin(dimer)/Ca2+ 0.055 0.047 -9999.0 0.0 -0.16 10.0 10.0 AKT1 -0.006 0.07 0.143 58.0 -0.16 1.0 59.0 PIK3R1 -0.001 0.092 -9999.0 0.0 -0.283 53.0 53.0 CDH1 0.023 0.04 -9999.0 0.0 -0.283 9.0 9.0 RhoA/GDP -0.04 0.079 0.241 4.0 -0.256 16.0 20.0 actin cytoskeleton organization -0.041 0.062 0.443 1.0 -0.225 7.0 8.0 CDC42/GDP -0.04 0.08 0.241 5.0 -0.257 15.0 20.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.014 0.063 -9999.0 0.0 -0.201 37.0 37.0 ITGB7 0.028 0.03 -9999.0 0.0 -0.283 5.0 5.0 RAC1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.06 0.051 -9999.0 0.0 -0.171 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.042 0.037 -9999.0 0.0 -0.15 10.0 10.0 mol:GDP -0.039 0.086 0.243 5.0 -0.284 18.0 23.0 CDC42/GTP/IQGAP1 0.04 0.016 -9999.0 0.0 -0.168 2.0 2.0 JUP 0.022 0.049 -9999.0 0.0 -0.283 14.0 14.0 p120 catenin/RhoA/GDP -0.041 0.083 0.246 4.0 -0.263 14.0 18.0 RAC1/GTP/IQGAP1 0.038 0.017 -9999.0 0.0 -0.168 2.0 2.0 PIP5K1C/AP1M1 0.039 0.018 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.031 0.014 -9999.0 0.0 -0.283 1.0 1.0 CDC42 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.03 0.014 -9999.0 0.0 -0.283 1.0 1.0 positive regulation of S phase of mitotic cell cycle -0.047 0.065 0.118 1.0 -0.146 143.0 144.0 NME1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.038 0.109 -9999.0 0.0 -0.323 68.0 68.0 regulation of cell-cell adhesion -0.05 0.041 0.087 22.0 -0.203 2.0 24.0 WASF2 -0.038 0.04 0.094 4.0 -0.112 42.0 46.0 Rap1/GTP -0.05 0.059 0.158 26.0 -0.289 1.0 27.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.073 -9999.0 0.0 -0.182 25.0 25.0 CCND1 -0.057 0.079 0.136 1.0 -0.178 146.0 147.0 VAV2 -0.034 0.164 -9999.0 0.0 -0.669 22.0 22.0 RAP1/GDP -0.042 0.067 0.259 3.0 -0.267 2.0 5.0 adherens junction assembly -0.037 0.106 -9999.0 0.0 -0.314 68.0 68.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.011 0.069 -9999.0 0.0 -0.184 24.0 24.0 E-cadherin/beta catenin -0.008 0.053 -9999.0 0.0 -0.184 42.0 42.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.036 0.106 -9999.0 0.0 -0.326 62.0 62.0 PIK3CA 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.086 0.117 -9999.0 0.0 -0.394 35.0 35.0 E-cadherin/beta catenin/alpha catenin 0.051 0.038 -9999.0 0.0 -0.179 10.0 10.0 ITGAE 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.021 0.118 -9999.0 0.0 -0.33 68.0 68.0