Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.032 0.036 0.244 1.0 -9999.0 0.0 1.0 KIRREL 0.025 0.03 -9999.0 0.0 -0.053 51.0 51.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.032 0.037 -9999.0 0.0 -0.245 1.0 1.0 PLCG1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.067 0.039 -9999.0 0.0 -9999.0 0.0 0.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.018 0.034 -9999.0 0.0 -0.21 1.0 1.0 FYN -0.002 0.065 0.147 78.0 -0.267 1.0 79.0 mol:Ca2+ 0.063 0.039 -9999.0 0.0 -0.204 1.0 1.0 mol:DAG 0.065 0.04 -9999.0 0.0 -0.204 1.0 1.0 NPHS2 0.027 0.027 -9999.0 0.0 -0.049 51.0 51.0 mol:IP3 0.065 0.04 -9999.0 0.0 -0.204 1.0 1.0 regulation of endocytosis 0.034 0.056 -9999.0 0.0 -0.26 1.0 1.0 Nephrin/NEPH1/podocin/Cholesterol 0.052 0.03 -9999.0 0.0 -0.194 1.0 1.0 establishment of cell polarity 0.032 0.036 -9999.0 0.0 -0.244 1.0 1.0 Nephrin/NEPH1/podocin/NCK1-2 0.084 0.047 -9999.0 0.0 -0.196 1.0 1.0 Nephrin/NEPH1/beta Arrestin2 0.036 0.058 -9999.0 0.0 -0.263 1.0 1.0 NPHS1 0.024 0.026 -9999.0 0.0 -0.049 51.0 51.0 Nephrin/NEPH1/podocin 0.034 0.054 0.192 3.0 -0.113 51.0 54.0 TJP1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.066 0.041 -9999.0 0.0 -0.205 1.0 1.0 CD2AP 0.029 0.02 -9999.0 0.0 -0.283 2.0 2.0 Nephrin/NEPH1/podocin/GRB2 0.067 0.04 -9999.0 0.0 -0.205 1.0 1.0 GRB2 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.009 0.072 0.153 84.0 -0.185 1.0 85.0 cytoskeleton organization -0.012 0.049 0.203 12.0 -0.234 1.0 13.0 Nephrin/NEPH1 0.035 0.019 -9999.0 0.0 -0.163 1.0 1.0 Nephrin/NEPH1/ZO-1 0.052 0.031 -9999.0 0.0 -0.201 1.0 1.0