Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.033 0.067 -9999.0 0.0 -0.503 5.0 5.0 IHH 0.056 0.063 0.226 7.0 -0.146 15.0 22.0 SHH Np/Cholesterol/GAS1 -0.041 0.04 0.144 1.0 -0.162 49.0 50.0 LRPAP1 0.029 0.02 -9999.0 0.0 -0.283 2.0 2.0 dorsoventral neural tube patterning 0.04 0.04 0.162 49.0 -0.142 1.0 50.0 SMO/beta Arrestin2 0.07 0.143 0.306 108.0 -0.433 10.0 118.0 SMO 0.049 0.152 0.316 111.0 -0.445 10.0 121.0 AKT1 0.011 0.134 0.27 16.0 -0.418 13.0 29.0 ARRB2 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.001 0.094 -9999.0 0.0 -0.283 56.0 56.0 ADRBK1 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.048 0.152 0.315 111.0 -0.439 10.0 121.0 STIL 0.007 0.077 0.282 29.0 -9999.0 0.0 29.0 DHH N/PTCH2 0.045 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.073 0.136 0.323 106.0 -0.31 15.0 121.0 PIK3CA 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.031 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.06 0.216 0.507 94.0 -0.459 5.0 99.0 determination of left/right symmetry 0.048 0.152 0.315 111.0 -0.439 10.0 121.0 PIK3R1 -0.001 0.092 -9999.0 0.0 -0.283 53.0 53.0 skeletal system development 0.06 0.216 0.506 94.0 -0.456 5.0 99.0 IHH N/Hhip 0.054 0.05 0.185 3.0 -0.194 6.0 9.0 DHH N/Hhip 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.048 0.152 0.315 111.0 -0.439 10.0 121.0 pancreas development 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.027 0.033 -9999.0 0.0 -0.283 6.0 6.0 PI3K 0.012 0.062 -9999.0 0.0 -0.204 37.0 37.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.004 0.088 -9999.0 0.0 -0.283 48.0 48.0 somite specification 0.048 0.152 0.315 111.0 -0.439 10.0 121.0 SHH Np/Cholesterol/PTCH1 0.017 0.132 0.277 102.0 -0.311 10.0 112.0 SHH Np/Cholesterol/PTCH2 -0.03 0.018 0.144 1.0 -0.16 6.0 7.0 SHH Np/Cholesterol/Megalin -0.023 0.02 -9999.0 0.0 -0.159 5.0 5.0 SHH -0.03 0.022 0.192 1.0 -0.204 6.0 7.0 catabolic process 0.049 0.179 0.388 111.0 -0.372 10.0 121.0 SMO/Vitamin D3 0.022 0.137 0.265 102.0 -0.412 10.0 112.0 SHH Np/Cholesterol/Hhip -0.03 0.019 0.144 1.0 -0.16 6.0 7.0 LRP2 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis 0.047 0.145 0.294 103.0 -0.431 10.0 113.0 SHH Np/Cholesterol/BOC -0.042 0.042 0.144 1.0 -0.16 58.0 59.0 SHH Np/Cholesterol/CDO -0.03 0.02 0.144 1.0 -0.16 8.0 9.0 mesenchymal cell differentiation 0.03 0.019 0.159 6.0 -0.142 1.0 7.0 mol:Vitamin D3 -0.018 0.084 0.209 45.0 -0.312 10.0 55.0 IHH N/PTCH2 0.055 0.049 0.185 4.0 -0.194 6.0 10.0 CDON 0.028 0.02 -9999.0 0.0 -0.283 2.0 2.0 IHH N/PTCH1 0.011 0.066 -9999.0 0.0 -0.34 15.0 15.0 Megalin/LRPAP1 0.032 0.026 -9999.0 0.0 -0.204 2.0 2.0 PTCH2 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.021 0.017 0.16 1.0 -0.15 6.0 7.0 PTCH1 0.049 0.179 0.389 111.0 -0.373 10.0 121.0 HHIP 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0