Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.067 0.238 -9999.0 0.0 -0.749 2.0 2.0 IHH -0.151 0.339 -9999.0 0.0 -0.828 11.0 11.0 SHH Np/Cholesterol/GAS1 -0.113 0.236 -9999.0 0.0 -0.574 11.0 11.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.112 0.234 0.569 11.0 -9999.0 0.0 11.0 SMO/beta Arrestin2 -0.064 0.23 -9999.0 0.0 -0.709 3.0 3.0 SMO -0.075 0.243 -9999.0 0.0 -0.755 3.0 3.0 AKT1 -0.013 0.112 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.003 0.119 -9999.0 0.0 -0.889 1.0 1.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.073 0.239 -9999.0 0.0 -0.739 3.0 3.0 STIL -0.112 0.28 -9999.0 0.0 -0.737 6.0 6.0 DHH N/PTCH2 -0.108 0.246 -9999.0 0.0 -0.67 9.0 9.0 DHH N/PTCH1 -0.17 0.247 -9999.0 0.0 -0.633 8.0 8.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.097 0.294 -9999.0 0.0 -0.874 7.0 7.0 PTHLH -0.083 0.289 -9999.0 0.0 -1.048 2.0 2.0 determination of left/right symmetry -0.073 0.239 -9999.0 0.0 -0.739 3.0 3.0 PIK3R1 -0.003 0.119 -9999.0 0.0 -0.889 1.0 1.0 skeletal system development -0.082 0.286 -9999.0 0.0 -1.03 2.0 2.0 IHH N/Hhip -0.186 0.351 -9999.0 0.0 -0.706 16.0 16.0 DHH N/Hhip -0.178 0.315 -9999.0 0.0 -0.711 14.0 14.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.073 0.239 -9999.0 0.0 -0.739 3.0 3.0 pancreas development -0.111 0.306 -9999.0 0.0 -0.861 8.0 8.0 HHAT 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.012 0.092 -9999.0 0.0 -0.691 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.031 0.188 -9999.0 0.0 -0.818 3.0 3.0 somite specification -0.073 0.239 -9999.0 0.0 -0.739 3.0 3.0 SHH Np/Cholesterol/PTCH1 -0.128 0.294 -9999.0 0.0 -0.786 6.0 6.0 SHH Np/Cholesterol/PTCH2 -0.104 0.235 -9999.0 0.0 -0.584 10.0 10.0 SHH Np/Cholesterol/Megalin -0.187 0.291 -9999.0 0.0 -0.582 18.0 18.0 SHH -0.087 0.256 -9999.0 0.0 -0.671 9.0 9.0 catabolic process -0.076 0.236 -9999.0 0.0 -0.582 7.0 7.0 SMO/Vitamin D3 -0.119 0.297 -9999.0 0.0 -0.78 6.0 6.0 SHH Np/Cholesterol/Hhip -0.162 0.267 -9999.0 0.0 -0.569 16.0 16.0 LRP2 -0.156 0.339 -9999.0 0.0 -0.841 11.0 11.0 receptor-mediated endocytosis -0.215 0.298 -9999.0 0.0 -0.757 11.0 11.0 SHH Np/Cholesterol/BOC -0.096 0.207 -9999.0 0.0 -0.54 10.0 10.0 SHH Np/Cholesterol/CDO -0.096 0.227 -9999.0 0.0 -0.597 9.0 9.0 mesenchymal cell differentiation 0.161 0.264 0.563 16.0 -9999.0 0.0 16.0 mol:Vitamin D3 -0.126 0.296 -9999.0 0.0 -0.787 6.0 6.0 IHH N/PTCH2 -0.111 0.268 -9999.0 0.0 -0.607 12.0 12.0 CDON -0.003 0.119 -9999.0 0.0 -0.889 1.0 1.0 IHH N/PTCH1 -0.078 0.238 -9999.0 0.0 -0.589 7.0 7.0 Megalin/LRPAP1 -0.127 0.258 -9999.0 0.0 -0.647 11.0 11.0 PTCH2 -0.017 0.158 -9999.0 0.0 -0.836 2.0 2.0 SHH Np/Cholesterol -0.088 0.201 -9999.0 0.0 -0.547 9.0 9.0 PTCH1 -0.077 0.237 -9999.0 0.0 -0.584 7.0 7.0 HHIP -0.112 0.307 -9999.0 0.0 -0.862 8.0 8.0