Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.117 0.19 0.337 22.0 -9999.0 0.0 22.0 KIRREL -0.021 0.105 -9999.0 0.0 -0.525 2.0 2.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.117 0.19 -9999.0 0.0 -0.337 22.0 22.0 PLCG1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.078 0.174 -9999.0 0.0 -0.366 9.0 9.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.056 0.126 -9999.0 0.0 -0.323 8.0 8.0 FYN -0.084 0.155 0.267 2.0 -0.343 9.0 11.0 mol:Ca2+ -0.067 0.166 -9999.0 0.0 -0.387 7.0 7.0 mol:DAG -0.067 0.168 -9999.0 0.0 -0.389 7.0 7.0 NPHS2 -0.037 0.117 -9999.0 0.0 -0.434 4.0 4.0 mol:IP3 -0.067 0.168 -9999.0 0.0 -0.389 7.0 7.0 regulation of endocytosis -0.068 0.147 -9999.0 0.0 -0.32 9.0 9.0 Nephrin/NEPH1/podocin/Cholesterol -0.086 0.166 -9999.0 0.0 -0.263 23.0 23.0 establishment of cell polarity -0.117 0.19 -9999.0 0.0 -0.337 22.0 22.0 Nephrin/NEPH1/podocin/NCK1-2 -0.058 0.166 -9999.0 0.0 -0.348 8.0 8.0 Nephrin/NEPH1/beta Arrestin2 -0.068 0.15 -9999.0 0.0 -0.323 9.0 9.0 NPHS1 -0.164 0.238 -9999.0 0.0 -0.45 22.0 22.0 Nephrin/NEPH1/podocin -0.077 0.155 -9999.0 0.0 -0.345 9.0 9.0 TJP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.067 0.169 -9999.0 0.0 -0.39 7.0 7.0 CD2AP 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.076 0.169 -9999.0 0.0 -0.375 8.0 8.0 GRB2 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.073 0.152 0.278 2.0 -0.358 7.0 9.0 cytoskeleton organization -0.082 0.153 -9999.0 0.0 -0.406 8.0 8.0 Nephrin/NEPH1 -0.078 0.136 -9999.0 0.0 -0.234 22.0 22.0 Nephrin/NEPH1/ZO-1 -0.08 0.161 -9999.0 0.0 -0.266 22.0 22.0