Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.004 0.208 -9999.0 0.0 -0.776 5.0 5.0 IHH 0.011 0.06 -9999.0 0.0 -0.456 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.267 0.298 -9999.0 0.0 -0.574 40.0 40.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.265 0.295 0.569 40.0 -9999.0 0.0 40.0 SMO/beta Arrestin2 -0.025 0.105 -9999.0 0.0 -0.524 1.0 1.0 SMO -0.033 0.11 -9999.0 0.0 -0.555 1.0 1.0 AKT1 0.004 0.054 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.013 0.089 -9999.0 0.0 -0.31 7.0 7.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.032 0.108 -9999.0 0.0 -0.547 1.0 1.0 STIL -0.204 0.255 -9999.0 0.0 -0.464 39.0 39.0 DHH N/PTCH2 -0.008 0.113 -9999.0 0.0 -0.668 2.0 2.0 DHH N/PTCH1 0.012 0.101 -9999.0 0.0 -0.494 1.0 1.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.003 0.069 -9999.0 0.0 -0.31 4.0 4.0 PTHLH -0.0 0.2 -9999.0 0.0 -0.648 7.0 7.0 determination of left/right symmetry -0.032 0.108 -9999.0 0.0 -0.547 1.0 1.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.0 0.199 -9999.0 0.0 -0.642 7.0 7.0 IHH N/Hhip 0.005 0.075 -9999.0 0.0 -0.455 1.0 1.0 DHH N/Hhip -0.005 0.068 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.032 0.108 -9999.0 0.0 -0.547 1.0 1.0 pancreas development -0.006 0.076 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.01 0.035 -9999.0 0.0 -0.31 1.0 1.0 PI3K 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.043 0.144 -9999.0 0.0 -0.353 13.0 13.0 somite specification -0.032 0.108 -9999.0 0.0 -0.547 1.0 1.0 SHH Np/Cholesterol/PTCH1 -0.22 0.268 -9999.0 0.0 -0.492 40.0 40.0 SHH Np/Cholesterol/PTCH2 -0.252 0.294 -9999.0 0.0 -0.555 40.0 40.0 SHH Np/Cholesterol/Megalin -0.311 0.339 -9999.0 0.0 -0.612 44.0 44.0 SHH -0.302 0.347 -9999.0 0.0 -0.674 39.0 39.0 catabolic process 0.016 0.108 -9999.0 0.0 -0.554 1.0 1.0 SMO/Vitamin D3 -0.197 0.253 -9999.0 0.0 -0.453 40.0 40.0 SHH Np/Cholesterol/Hhip -0.249 0.276 -9999.0 0.0 -0.542 39.0 39.0 LRP2 -0.106 0.293 -9999.0 0.0 -0.861 11.0 11.0 receptor-mediated endocytosis -0.218 0.264 -9999.0 0.0 -0.663 10.0 10.0 SHH Np/Cholesterol/BOC -0.251 0.295 -9999.0 0.0 -0.564 39.0 39.0 SHH Np/Cholesterol/CDO -0.239 0.283 -9999.0 0.0 -0.542 39.0 39.0 mesenchymal cell differentiation 0.247 0.274 0.538 39.0 -9999.0 0.0 39.0 mol:Vitamin D3 -0.217 0.268 -9999.0 0.0 -0.489 40.0 40.0 IHH N/PTCH2 0.002 0.118 -9999.0 0.0 -0.719 2.0 2.0 CDON 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.018 0.109 -9999.0 0.0 -0.56 1.0 1.0 Megalin/LRPAP1 -0.073 0.231 -9999.0 0.0 -0.668 11.0 11.0 PTCH2 -0.007 0.133 -9999.0 0.0 -0.861 2.0 2.0 SHH Np/Cholesterol -0.247 0.282 -9999.0 0.0 -0.549 39.0 39.0 PTCH1 0.016 0.108 -9999.0 0.0 -0.556 1.0 1.0 HHIP -0.006 0.077 -9999.0 0.0 -9999.0 0.0 0.0