Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within Syndecan-1-mediated signaling events 36.0 1233.0 34.0 -0.84 0.013 1000.0 -1000.0 -0.06 -1000.0 Reelin signaling pathway 24.0 1362.0 56.0 -0.726 0.04 1000.0 -1000.0 -0.09 -1000.0 IL23-mediated signaling events 17.0 1039.0 60.0 -0.685 0.021 1000.0 -1000.0 -0.186 -1000.0 TCGA08_retinoblastoma 16.0 130.0 8.0 -0.201 0.065 1000.0 -1000.0 -0.024 -1000.0 Osteopontin-mediated events 15.0 570.0 38.0 -0.341 0.02 1000.0 -1000.0 -0.11 -1000.0 Glypican 1 network 15.0 762.0 48.0 -0.605 0.03 1000.0 -1000.0 -0.052 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 14.0 780.0 54.0 -0.705 0.026 1000.0 -1000.0 -0.109 -1000.0 TCGA08_p53 14.0 104.0 7.0 -0.153 0.074 1000.0 -1000.0 -0.011 -1000.0 Signaling events mediated by the Hedgehog family 12.0 651.0 52.0 -0.311 0.265 1000.0 -1000.0 -0.056 -1000.0 IL4-mediated signaling events 12.0 1116.0 91.0 -0.791 0.64 1000.0 -1000.0 -0.191 -1000.0 Wnt signaling 11.0 77.0 7.0 -0.247 0.013 1000.0 -1000.0 -0.029 -1000.0 Caspase cascade in apoptosis 10.0 765.0 74.0 -0.277 0.129 1000.0 -1000.0 -0.052 -1000.0 FOXA2 and FOXA3 transcription factor networks 10.0 505.0 46.0 -0.745 0.02 1000.0 -1000.0 -0.154 -1000.0 Syndecan-4-mediated signaling events 8.0 555.0 67.0 -0.538 0.053 1000.0 -1000.0 -0.078 -1000.0 HIF-1-alpha transcription factor network 7.0 540.0 76.0 -0.812 0.022 1000.0 -1000.0 -0.172 -1000.0 BMP receptor signaling 7.0 596.0 81.0 -0.372 0.049 1000.0 -1000.0 -0.108 -1000.0 Glucocorticoid receptor regulatory network 7.0 905.0 114.0 -0.762 0.348 1000.0 -1000.0 -0.077 -1000.0 Endothelins 7.0 694.0 96.0 -0.487 0.051 1000.0 -1000.0 -0.088 -1000.0 Canonical Wnt signaling pathway 7.0 377.0 51.0 -0.56 0.253 1000.0 -1000.0 -0.072 -1000.0 Syndecan-2-mediated signaling events 6.0 434.0 69.0 -0.517 0.036 1000.0 -1000.0 -0.036 -1000.0 Presenilin action in Notch and Wnt signaling 6.0 403.0 61.0 -0.559 0.222 1000.0 -1000.0 -0.08 -1000.0 HIF-2-alpha transcription factor network 6.0 290.0 43.0 -0.314 0.217 1000.0 -1000.0 -0.081 -1000.0 Glypican 2 network 6.0 27.0 4.0 -0.07 -0.053 1000.0 -1000.0 -0.02 -1000.0 Calcium signaling in the CD4+ TCR pathway 6.0 199.0 31.0 -0.58 0.013 1000.0 -1000.0 -0.07 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 5.0 173.0 34.0 -0.07 0.013 1000.0 -1000.0 -0.06 -1000.0 IL1-mediated signaling events 5.0 332.0 62.0 -0.309 0.06 1000.0 -1000.0 -0.107 -1000.0 Ephrin B reverse signaling 5.0 253.0 48.0 -0.102 0.04 1000.0 -1000.0 -0.071 -1000.0 Visual signal transduction: Rods 5.0 263.0 52.0 -0.183 0.013 1000.0 -1000.0 -0.081 -1000.0 Signaling events mediated by PRL 5.0 195.0 34.0 -0.257 0.059 1000.0 -1000.0 -0.033 -1000.0 Ras signaling in the CD4+ TCR pathway 5.0 95.0 17.0 -0.071 0.02 1000.0 -1000.0 -0.053 -1000.0 Ephrin A reverse signaling 4.0 33.0 7.0 -0.06 -0.0 1000.0 -1000.0 -0.025 -1000.0 JNK signaling in the CD4+ TCR pathway 4.0 76.0 17.0 -0.114 0.027 1000.0 -1000.0 -0.041 -1000.0 Noncanonical Wnt signaling pathway 4.0 106.0 26.0 -0.247 0.013 1000.0 -1000.0 -0.059 -1000.0 Aurora A signaling 4.0 252.0 60.0 -0.445 0.037 1000.0 -1000.0 -0.041 -1000.0 amb2 Integrin signaling 4.0 385.0 82.0 -0.163 0.018 1000.0 -1000.0 -0.078 -1000.0 S1P1 pathway 4.0 178.0 36.0 -0.141 0.015 1000.0 -1000.0 -0.058 -1000.0 Retinoic acid receptors-mediated signaling 4.0 245.0 58.0 -0.296 0.028 1000.0 -1000.0 -0.088 -1000.0 Syndecan-3-mediated signaling events 4.0 157.0 35.0 -0.517 0.04 1000.0 -1000.0 -0.053 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 4.0 304.0 68.0 -0.58 0.048 1000.0 -1000.0 -0.135 -1000.0 BCR signaling pathway 4.0 429.0 99.0 -0.136 0.017 1000.0 -1000.0 -0.102 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 4.0 381.0 78.0 -0.075 0.029 1000.0 -1000.0 -0.07 -1000.0 IL12-mediated signaling events 3.0 264.0 87.0 -0.216 0.047 1000.0 -1000.0 -0.153 -1000.0 ErbB4 signaling events 3.0 228.0 69.0 -0.445 0.077 1000.0 -1000.0 -0.096 -1000.0 Sphingosine 1-phosphate (S1P) pathway 3.0 86.0 28.0 -0.141 0.02 1000.0 -1000.0 -0.035 -1000.0 Visual signal transduction: Cones 3.0 145.0 38.0 -0.154 0.019 1000.0 -1000.0 -0.041 -1000.0 p75(NTR)-mediated signaling 3.0 465.0 125.0 -1.002 0.04 1000.0 -1000.0 -0.106 -1000.0 Fc-epsilon receptor I signaling in mast cells 3.0 302.0 97.0 -0.105 0.033 1000.0 -1000.0 -0.105 -1000.0 IFN-gamma pathway 3.0 240.0 68.0 -0.121 0.027 1000.0 -1000.0 -0.103 -1000.0 Nectin adhesion pathway 3.0 192.0 63.0 -0.84 0.053 1000.0 -1000.0 -0.075 -1000.0 S1P5 pathway 3.0 61.0 17.0 -0.141 0.065 1000.0 -1000.0 -0.043 -1000.0 EPHB forward signaling 3.0 281.0 85.0 -0.101 0.053 1000.0 -1000.0 -0.093 -1000.0 Effects of Botulinum toxin 3.0 98.0 26.0 -0.079 0.025 1000.0 -1000.0 -0.073 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 3.0 393.0 125.0 -0.067 0.05 1000.0 -1000.0 -0.106 -1000.0 IL27-mediated signaling events 3.0 169.0 51.0 -0.351 0.054 1000.0 -1000.0 -0.088 -1000.0 LPA receptor mediated events 3.0 311.0 102.0 -0.268 0.036 1000.0 -1000.0 -0.1 -1000.0 EGFR-dependent Endothelin signaling events 3.0 75.0 21.0 -0.091 0.02 1000.0 -1000.0 -0.082 -1000.0 Thromboxane A2 receptor signaling 2.0 292.0 105.0 -0.203 0.1 1000.0 -1000.0 -0.075 -1000.0 Cellular roles of Anthrax toxin 2.0 81.0 39.0 -0.084 0.013 1000.0 -1000.0 -0.024 -1000.0 Signaling events mediated by PTP1B 2.0 199.0 76.0 -0.475 0.083 1000.0 -1000.0 -0.09 -1000.0 PLK1 signaling events 2.0 182.0 85.0 -0.193 0.028 1000.0 -1000.0 -0.046 -1000.0 Signaling mediated by p38-alpha and p38-beta 2.0 88.0 44.0 -0.048 0.013 1000.0 -1000.0 -0.048 -1000.0 Integrins in angiogenesis 2.0 228.0 84.0 -0.34 0.031 1000.0 -1000.0 -0.102 -1000.0 TCR signaling in naïve CD8+ T cells 2.0 239.0 93.0 -0.122 0.038 1000.0 -1000.0 -0.086 -1000.0 Nongenotropic Androgen signaling 2.0 121.0 52.0 -0.141 0.027 1000.0 -1000.0 -0.061 -1000.0 IL6-mediated signaling events 2.0 164.0 75.0 -0.098 0.056 1000.0 -1000.0 -0.092 -1000.0 Plasma membrane estrogen receptor signaling 2.0 205.0 86.0 -0.255 0.036 1000.0 -1000.0 -0.091 -1000.0 VEGFR1 specific signals 2.0 159.0 56.0 -0.07 0.037 1000.0 -1000.0 -0.058 -1000.0 Angiopoietin receptor Tie2-mediated signaling 2.0 190.0 88.0 -0.301 0.104 1000.0 -1000.0 -0.11 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 2.0 75.0 33.0 -0.195 0.035 1000.0 -1000.0 -0.052 -1000.0 S1P4 pathway 2.0 55.0 25.0 -0.141 0.029 1000.0 -1000.0 -0.043 -1000.0 ErbB2/ErbB3 signaling events 1.0 113.0 65.0 -0.12 0.041 1000.0 -1000.0 -0.071 -1000.0 Regulation of nuclear SMAD2/3 signaling 1.0 266.0 136.0 -0.213 0.212 1000.0 -1000.0 -0.075 -1000.0 Coregulation of Androgen receptor activity 1.0 124.0 76.0 -0.22 0.047 1000.0 -1000.0 -0.046 -1000.0 Arf6 signaling events 1.0 118.0 62.0 -0.119 0.028 1000.0 -1000.0 -0.059 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 1.0 92.0 85.0 -0.039 0.047 1000.0 -1000.0 -0.08 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 1.0 46.0 37.0 -0.141 0.043 1000.0 -1000.0 -0.054 -1000.0 Signaling events mediated by HDAC Class III 1.0 47.0 40.0 -0.098 0.024 1000.0 -1000.0 -0.029 -1000.0 Signaling events regulated by Ret tyrosine kinase 1.0 152.0 82.0 -0.121 0.013 1000.0 -1000.0 -0.093 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 1.0 76.0 52.0 -0.166 0.035 1000.0 -1000.0 -0.043 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 1.0 102.0 83.0 -0.299 0.069 1000.0 -1000.0 -0.077 -1000.0 FAS signaling pathway (CD95) 1.0 56.0 47.0 -0.06 0.028 1000.0 -1000.0 -0.059 -1000.0 Class I PI3K signaling events 1.0 74.0 73.0 -0.126 0.037 1000.0 -1000.0 -0.079 -1000.0 Regulation of Telomerase 1.0 182.0 102.0 -0.487 0.047 1000.0 -1000.0 -0.119 -1000.0 S1P3 pathway 1.0 70.0 42.0 -0.139 0.029 1000.0 -1000.0 -0.043 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 1.0 207.0 120.0 -0.104 0.07 1000.0 -1000.0 -0.078 -1000.0 PDGFR-beta signaling pathway 1.0 189.0 97.0 -0.2 0.044 1000.0 -1000.0 -0.095 -1000.0 E-cadherin signaling in keratinocytes 1.0 45.0 43.0 -0.227 0.051 1000.0 -1000.0 -0.054 -1000.0 FOXM1 transcription factor network 1.0 88.0 51.0 -0.231 0.048 1000.0 -1000.0 -0.227 -1000.0 Regulation of Androgen receptor activity 1.0 101.0 70.0 -0.268 0.04 1000.0 -1000.0 -0.068 -1000.0 Aurora B signaling 1.0 111.0 67.0 -0.339 0.072 1000.0 -1000.0 -0.06 -1000.0 LPA4-mediated signaling events 0.0 3.0 12.0 -0.068 0.017 1000.0 -1000.0 -0.028 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 2.0 23.0 0.003 0.042 1000.0 -1000.0 -0.06 -1000.0 Canonical NF-kappaB pathway 0.0 18.0 39.0 -0.07 0.063 1000.0 -1000.0 -0.08 -1000.0 Signaling events mediated by HDAC Class II 0.0 13.0 75.0 -0.028 0.04 1000.0 -1000.0 -0.044 -1000.0 BARD1 signaling events 0.0 37.0 57.0 -0.027 0.047 1000.0 -1000.0 -0.068 -1000.0 PLK2 and PLK4 events 0.0 0.0 3.0 0.013 0.021 1000.0 -1000.0 -0.027 -1000.0 Circadian rhythm pathway 0.0 7.0 22.0 -0.011 0.045 1000.0 -1000.0 -0.05 -1000.0 a4b1 and a4b7 Integrin signaling 0.0 2.0 5.0 0.006 0.015 1000.0 -1000.0 -0.02 -1000.0 Hedgehog signaling events mediated by Gli proteins 0.0 43.0 65.0 -0.14 0.058 1000.0 -1000.0 -0.072 -1000.0 Arf6 downstream pathway 0.0 12.0 43.0 -0.027 0.031 1000.0 -1000.0 -0.046 -1000.0 Aurora C signaling 0.0 0.0 7.0 -0.0 0.026 1000.0 -1000.0 -0.031 -1000.0 EPO signaling pathway 0.0 23.0 55.0 -0.005 0.065 1000.0 -1000.0 -0.1 -1000.0 Insulin-mediated glucose transport 0.0 4.0 32.0 -0.004 0.04 1000.0 -1000.0 -0.056 -1000.0 PDGFR-alpha signaling pathway 0.0 14.0 44.0 -0.007 0.034 1000.0 -1000.0 -0.05 -1000.0 mTOR signaling pathway 0.0 2.0 53.0 -0.0 0.037 1000.0 -1000.0 -0.066 -1000.0 Class I PI3K signaling events mediated by Akt 0.0 6.0 68.0 -0.039 0.051 1000.0 -1000.0 -0.054 -1000.0 Ceramide signaling pathway 0.0 57.0 76.0 -0.089 0.049 1000.0 -1000.0 -0.058 -1000.0 TRAIL signaling pathway 0.0 29.0 48.0 -0.08 0.046 1000.0 -1000.0 -0.064 -1000.0 ceramide signaling pathway 0.0 3.0 49.0 0.0 0.052 1000.0 -1000.0 -0.062 -1000.0 Signaling events mediated by HDAC Class I 0.0 7.0 104.0 -0.027 0.05 1000.0 -1000.0 -0.057 -1000.0 FoxO family signaling 0.0 23.0 64.0 -0.151 0.127 1000.0 -1000.0 -0.084 -1000.0 Signaling mediated by p38-gamma and p38-delta 0.0 5.0 15.0 -0.038 0.026 1000.0 -1000.0 -0.039 -1000.0 Paxillin-dependent events mediated by a4b1 0.0 3.0 36.0 -0.035 0.036 1000.0 -1000.0 -0.074 -1000.0 Atypical NF-kappaB pathway 0.0 2.0 31.0 -0.007 0.043 1000.0 -1000.0 -0.047 -1000.0 IL2 signaling events mediated by PI3K 0.0 22.0 58.0 -0.049 0.076 1000.0 -1000.0 -0.094 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 0.0 10.0 45.0 -0.004 0.072 1000.0 -1000.0 -0.107 -1000.0 Regulation of p38-alpha and p38-beta 0.0 43.0 54.0 -0.126 0.035 1000.0 -1000.0 -0.067 -1000.0 TCGA08_rtk_signaling 0.0 25.0 26.0 -0.039 0.042 1000.0 -1000.0 -0.02 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 0.0 50.0 74.0 -0.089 0.069 1000.0 -1000.0 -0.096 -1000.0 E-cadherin signaling in the nascent adherens junction 0.0 14.0 76.0 -0.016 0.057 1000.0 -1000.0 -0.091 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 3.0 27.0 -0.002 0.035 1000.0 -1000.0 -0.06 -1000.0 IL2 signaling events mediated by STAT5 0.0 5.0 22.0 -0.007 0.06 1000.0 -1000.0 -0.064 -1000.0 Arf6 trafficking events 0.0 40.0 71.0 -0.037 0.04 1000.0 -1000.0 -0.077 -1000.0 IGF1 pathway 0.0 5.0 57.0 -0.036 0.04 1000.0 -1000.0 -0.104 -1000.0 Insulin Pathway 0.0 34.0 74.0 -0.094 0.037 1000.0 -1000.0 -0.105 -1000.0 Rapid glucocorticoid signaling 0.0 12.0 20.0 -0.01 0.018 1000.0 -1000.0 -0.027 -1000.0 Class IB PI3K non-lipid kinase events 0.0 0.0 3.0 -0.013 0.013 1000.0 -1000.0 -0.013 -1000.0 E-cadherin signaling events 0.0 0.0 5.0 0.013 0.028 1000.0 -1000.0 -0.021 -1000.0 p38 MAPK signaling pathway 0.0 29.0 44.0 -0.077 0.032 1000.0 -1000.0 -0.077 -1000.0 Arf1 pathway 0.0 17.0 54.0 -0.011 0.031 1000.0 -1000.0 -0.028 -1000.0 Alternative NF-kappaB pathway 0.0 0.0 13.0 0.0 0.04 1000.0 -1000.0 -0.039 -1000.0 Total 446 26442 7203 -27.8906226301 7.102830875 131000 -131000 -9.36850656438 -131000