Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.0 0.122 -9999.0 0.0 -0.418 6.0 6.0 IHH 0.018 0.055 -9999.0 0.0 -0.396 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.112 0.164 0.168 3.0 -0.287 36.0 39.0 LRPAP1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.112 0.163 0.285 36.0 -0.166 3.0 39.0 SMO/beta Arrestin2 -0.007 0.078 -9999.0 0.0 -0.428 1.0 1.0 SMO -0.015 0.075 -9999.0 0.0 -0.447 1.0 1.0 AKT1 -0.002 0.079 -9999.0 0.0 -0.353 2.0 2.0 ARRB2 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.003 0.085 -9999.0 0.0 -0.282 7.0 7.0 ADRBK1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.014 0.075 -9999.0 0.0 -0.441 1.0 1.0 STIL -0.081 0.136 -9999.0 0.0 -0.338 4.0 4.0 DHH N/PTCH2 0.014 0.072 -9999.0 0.0 -0.238 6.0 6.0 DHH N/PTCH1 0.016 0.08 -9999.0 0.0 -0.375 1.0 1.0 PIK3CA 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.006 0.066 -9999.0 0.0 -0.282 4.0 4.0 PTHLH -0.002 0.134 -9999.0 0.0 -0.7 2.0 2.0 determination of left/right symmetry -0.014 0.075 -9999.0 0.0 -0.441 1.0 1.0 PIK3R1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.002 0.133 -9999.0 0.0 -0.693 2.0 2.0 IHH N/Hhip 0.017 0.068 -9999.0 0.0 -0.259 4.0 4.0 DHH N/Hhip 0.011 0.065 -9999.0 0.0 -0.188 8.0 8.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.014 0.075 -9999.0 0.0 -0.441 1.0 1.0 pancreas development 0.007 0.065 -9999.0 0.0 -0.282 4.0 4.0 HHAT 0.019 0.033 -9999.0 0.0 -0.282 1.0 1.0 PI3K 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.027 0.117 -9999.0 0.0 -0.296 13.0 13.0 somite specification -0.014 0.075 -9999.0 0.0 -0.441 1.0 1.0 SHH Np/Cholesterol/PTCH1 -0.084 0.14 -9999.0 0.0 -0.353 4.0 4.0 SHH Np/Cholesterol/PTCH2 -0.096 0.151 0.168 3.0 -0.262 36.0 39.0 SHH Np/Cholesterol/Megalin -0.121 0.167 0.168 2.0 -0.286 39.0 41.0 SHH -0.126 0.183 0.244 3.0 -0.334 35.0 38.0 catabolic process 0.013 0.078 -9999.0 0.0 -0.345 2.0 2.0 SMO/Vitamin D3 -0.079 0.128 -9999.0 0.0 -0.343 4.0 4.0 SHH Np/Cholesterol/Hhip -0.098 0.142 0.168 3.0 -0.255 35.0 38.0 LRP2 -0.054 0.159 -9999.0 0.0 -0.459 11.0 11.0 receptor-mediated endocytosis -0.088 0.135 -9999.0 0.0 -0.334 9.0 9.0 SHH Np/Cholesterol/BOC -0.101 0.159 0.168 3.0 -0.277 35.0 38.0 SHH Np/Cholesterol/CDO -0.09 0.145 0.168 3.0 -0.256 35.0 38.0 mesenchymal cell differentiation 0.098 0.141 0.254 35.0 -0.166 3.0 38.0 mol:Vitamin D3 -0.081 0.144 -9999.0 0.0 -0.353 4.0 4.0 IHH N/PTCH2 0.02 0.069 -9999.0 0.0 -0.316 3.0 3.0 CDON 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.02 0.081 -9999.0 0.0 -0.348 2.0 2.0 Megalin/LRPAP1 -0.018 0.122 -9999.0 0.0 -0.329 11.0 11.0 PTCH2 0.011 0.074 -9999.0 0.0 -0.459 2.0 2.0 SHH Np/Cholesterol -0.1 0.132 -9999.0 0.0 -0.254 35.0 35.0 PTCH1 0.013 0.079 -9999.0 0.0 -0.346 2.0 2.0 HHIP 0.007 0.065 -9999.0 0.0 -0.282 4.0 4.0