Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Reelin signaling pathway	22.0	1244.0	56.0	-0.38	0.067	1000.0	-1000.0	-0.05	-1000.0
Syndecan-1-mediated signaling events	14.0	498.0	34.0	-0.45	0.023	1000.0	-1000.0	-0.044	-1000.0
Ephrin A  reverse signaling	14.0	100.0	7.0	-0.045	0.0	1000.0	-1000.0	-0.014	-1000.0
Glypican 1 network	14.0	712.0	48.0	-0.316	0.047	1000.0	-1000.0	-0.032	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	13.0	714.0	54.0	-0.373	0.032	1000.0	-1000.0	-0.056	-1000.0
IL4-mediated signaling events	13.0	1216.0	91.0	-0.763	0.6	1000.0	-1000.0	-0.162	-1000.0
TCGA08_retinoblastoma	12.0	101.0	8.0	-0.091	0.045	1000.0	-1000.0	-0.004	-1000.0
Osteopontin-mediated events	9.0	345.0	38.0	-0.178	0.034	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by the Hedgehog family	9.0	512.0	52.0	-0.126	0.112	1000.0	-1000.0	-0.046	-1000.0
HIF-1-alpha transcription factor network	8.0	609.0	76.0	-0.528	0.028	1000.0	-1000.0	-0.158	-1000.0
FOXA2 and FOXA3 transcription factor networks	8.0	410.0	46.0	-0.511	0.027	1000.0	-1000.0	-0.137	-1000.0
Endothelins	8.0	806.0	96.0	-0.276	0.027	1000.0	-1000.0	-0.052	-1000.0
Wnt signaling	8.0	56.0	7.0	-0.124	0.021	1000.0	-1000.0	-0.017	-1000.0
IL23-mediated signaling events	8.0	503.0	60.0	-0.416	0.031	1000.0	-1000.0	-0.118	-1000.0
BMP receptor signaling	7.0	610.0	81.0	-0.132	0.044	1000.0	-1000.0	-0.057	-1000.0
IL1-mediated signaling events	7.0	445.0	62.0	-0.155	0.101	1000.0	-1000.0	-0.052	-1000.0
Visual signal transduction: Rods	7.0	382.0	52.0	-0.151	0.025	1000.0	-1000.0	-0.04	-1000.0
Syndecan-2-mediated signaling events	6.0	476.0	69.0	-0.269	0.04	1000.0	-1000.0	-0.033	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	589.0	97.0	-0.115	0.043	1000.0	-1000.0	-0.063	-1000.0
HIF-2-alpha transcription factor network	6.0	284.0	43.0	-0.276	0.183	1000.0	-1000.0	-0.076	-1000.0
Glypican 2 network	6.0	27.0	4.0	-0.015	0.0	1000.0	-1000.0	-0.001	-1000.0
BCR signaling pathway	6.0	651.0	99.0	-0.136	0.028	1000.0	-1000.0	-0.056	-1000.0
Visual signal transduction: Cones	5.0	205.0	38.0	-0.093	0.039	1000.0	-1000.0	-0.017	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	92.0	17.0	-0.123	0.042	1000.0	-1000.0	-0.035	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	316.0	61.0	-0.282	0.133	1000.0	-1000.0	-0.038	-1000.0
p75(NTR)-mediated signaling	5.0	693.0	125.0	-0.47	0.063	1000.0	-1000.0	-0.07	-1000.0
Signaling events regulated by Ret tyrosine kinase	5.0	423.0	82.0	-0.106	0.026	1000.0	-1000.0	-0.058	-1000.0
Syndecan-3-mediated signaling events	5.0	178.0	35.0	-0.269	0.063	1000.0	-1000.0	-0.029	-1000.0
Canonical Wnt signaling pathway	5.0	291.0	51.0	-0.282	0.146	1000.0	-1000.0	-0.05	-1000.0
Calcium signaling in the CD4+ TCR pathway	5.0	165.0	31.0	-0.302	0.023	1000.0	-1000.0	-0.049	-1000.0
LPA receptor mediated events	5.0	579.0	102.0	-0.156	0.03	1000.0	-1000.0	-0.051	-1000.0
Syndecan-4-mediated signaling events	5.0	359.0	67.0	-0.279	0.034	1000.0	-1000.0	-0.043	-1000.0
PDGFR-beta signaling pathway	5.0	486.0	97.0	-0.117	0.087	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by PRL	5.0	172.0	34.0	-0.128	0.088	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	5.0	447.0	78.0	-0.113	0.027	1000.0	-1000.0	-0.067	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	93.0	17.0	-0.062	0.038	1000.0	-1000.0	-0.026	-1000.0
LPA4-mediated signaling events	4.0	57.0	12.0	-0.077	0.006	1000.0	-1000.0	-0.024	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	156.0	34.0	-0.022	0.034	1000.0	-1000.0	-0.03	-1000.0
Noncanonical Wnt signaling pathway	4.0	116.0	26.0	-0.124	0.023	1000.0	-1000.0	-0.042	-1000.0
amb2 Integrin signaling	4.0	405.0	82.0	-0.07	0.031	1000.0	-1000.0	-0.042	-1000.0
Glucocorticoid receptor regulatory network	4.0	562.0	114.0	-0.375	0.229	1000.0	-1000.0	-0.063	-1000.0
S1P5 pathway	4.0	71.0	17.0	-0.124	0.064	1000.0	-1000.0	-0.022	-1000.0
TCGA08_p53	4.0	30.0	7.0	-0.072	0.032	1000.0	-1000.0	-0.008	-1000.0
TCR signaling in naïve CD8+ T cells	4.0	427.0	93.0	-0.045	0.034	1000.0	-1000.0	-0.054	-1000.0
EPHB forward signaling	4.0	354.0	85.0	-0.045	0.056	1000.0	-1000.0	-0.061	-1000.0
Nongenotropic Androgen signaling	4.0	252.0	52.0	-0.124	0.057	1000.0	-1000.0	-0.041	-1000.0
VEGFR1 specific signals	4.0	272.0	56.0	-0.015	0.112	1000.0	-1000.0	-0.049	-1000.0
Caspase cascade in apoptosis	3.0	255.0	74.0	-0.137	0.071	1000.0	-1000.0	-0.04	-1000.0
Coregulation of Androgen receptor activity	3.0	229.0	76.0	-0.217	0.073	1000.0	-1000.0	-0.023	-1000.0
IL12-mediated signaling events	3.0	265.0	87.0	-0.107	0.049	1000.0	-1000.0	-0.112	-1000.0
Thromboxane A2 receptor signaling	3.0	349.0	105.0	-0.173	0.079	1000.0	-1000.0	-0.053	-1000.0
Arf6 signaling events	3.0	220.0	62.0	-0.099	0.052	1000.0	-1000.0	-0.035	-1000.0
PLK1 signaling events	3.0	284.0	85.0	-0.045	0.051	1000.0	-1000.0	-0.026	-1000.0
Nectin adhesion pathway	3.0	195.0	63.0	-0.438	0.07	1000.0	-1000.0	-0.053	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	157.0	52.0	-0.146	0.053	1000.0	-1000.0	-0.047	-1000.0
Ephrin B reverse signaling	3.0	161.0	48.0	-0.036	0.026	1000.0	-1000.0	-0.037	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	137.0	44.0	-0.034	0.024	1000.0	-1000.0	-0.034	-1000.0
Effects of Botulinum toxin	3.0	100.0	26.0	-0.066	0.045	1000.0	-1000.0	-0.013	-1000.0
EGFR-dependent Endothelin signaling events	3.0	78.0	21.0	-0.06	0.034	1000.0	-1000.0	-0.044	-1000.0
Plasma membrane estrogen receptor signaling	3.0	342.0	86.0	-0.272	0.042	1000.0	-1000.0	-0.061	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	295.0	88.0	-0.161	0.091	1000.0	-1000.0	-0.071	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	120.0	33.0	-0.091	0.058	1000.0	-1000.0	-0.039	-1000.0
S1P4 pathway	3.0	83.0	25.0	-0.124	0.039	1000.0	-1000.0	-0.03	-1000.0
Regulation of Androgen receptor activity	3.0	212.0	70.0	-0.275	0.07	1000.0	-1000.0	-0.054	-1000.0
ErbB4 signaling events	2.0	152.0	69.0	-0.228	0.075	1000.0	-1000.0	-0.045	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	76.0	28.0	-0.124	0.033	1000.0	-1000.0	-0.025	-1000.0
Cellular roles of Anthrax toxin	2.0	108.0	39.0	-0.044	0.023	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by PTP1B	2.0	189.0	76.0	-0.251	0.039	1000.0	-1000.0	-0.042	-1000.0
IFN-gamma pathway	2.0	152.0	68.0	-0.071	0.034	1000.0	-1000.0	-0.062	-1000.0
Ceramide signaling pathway	2.0	216.0	76.0	-0.06	0.063	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class III	2.0	81.0	40.0	-0.086	0.045	1000.0	-1000.0	-0.019	-1000.0
S1P1 pathway	2.0	105.0	36.0	-0.124	0.024	1000.0	-1000.0	-0.057	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	38.0	15.0	-0.055	0.023	1000.0	-1000.0	-0.033	-1000.0
Retinoic acid receptors-mediated signaling	2.0	152.0	58.0	-0.185	0.044	1000.0	-1000.0	-0.048	-1000.0
Integrins in angiogenesis	2.0	238.0	84.0	-0.176	0.052	1000.0	-1000.0	-0.051	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	2.0	186.0	68.0	-0.302	0.049	1000.0	-1000.0	-0.102	-1000.0
S1P3 pathway	2.0	97.0	42.0	-0.123	0.041	1000.0	-1000.0	-0.03	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	342.0	120.0	-0.076	0.066	1000.0	-1000.0	-0.05	-1000.0
Aurora B signaling	2.0	142.0	67.0	-0.367	0.09	1000.0	-1000.0	-0.036	-1000.0
ErbB2/ErbB3 signaling events	1.0	95.0	65.0	-0.104	0.034	1000.0	-1000.0	-0.053	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	214.0	136.0	-0.132	0.086	1000.0	-1000.0	-0.054	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	6.0	5.0	0.016	0.029	1000.0	-1000.0	0.001	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	168.0	85.0	-0.03	0.042	1000.0	-1000.0	-0.048	-1000.0
Aurora A signaling	1.0	84.0	60.0	-0.099	0.067	1000.0	-1000.0	-0.025	-1000.0
Insulin-mediated glucose transport	1.0	37.0	32.0	-0.113	0.042	1000.0	-1000.0	-0.026	-1000.0
PDGFR-alpha signaling pathway	1.0	54.0	44.0	-0.011	0.059	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	99.0	68.0	-0.064	0.081	1000.0	-1000.0	-0.034	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	51.0	37.0	-0.115	0.053	1000.0	-1000.0	-0.039	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	100.0	83.0	-0.146	0.07	1000.0	-1000.0	-0.04	-1000.0
FAS signaling pathway (CD95)	1.0	71.0	47.0	-0.038	0.034	1000.0	-1000.0	-0.046	-1000.0
Atypical NF-kappaB pathway	1.0	35.0	31.0	-0.0	0.058	1000.0	-1000.0	-0.028	-1000.0
Regulation of p38-alpha and p38-beta	1.0	71.0	54.0	-0.073	0.049	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	174.0	125.0	-0.013	0.099	1000.0	-1000.0	-0.052	-1000.0
IL27-mediated signaling events	1.0	91.0	51.0	-0.134	0.053	1000.0	-1000.0	-0.043	-1000.0
TCGA08_rtk_signaling	1.0	28.0	26.0	-0.031	0.06	1000.0	-1000.0	-0.018	-1000.0
IL6-mediated signaling events	1.0	128.0	75.0	-0.036	0.069	1000.0	-1000.0	-0.072	-1000.0
Class I PI3K signaling events	1.0	107.0	73.0	-0.073	0.046	1000.0	-1000.0	-0.042	-1000.0
Regulation of Telomerase	1.0	170.0	102.0	-0.261	0.058	1000.0	-1000.0	-0.063	-1000.0
FOXM1 transcription factor network	1.0	55.0	51.0	-0.107	0.036	1000.0	-1000.0	-0.152	-1000.0
p38 MAPK signaling pathway	1.0	67.0	44.0	-0.055	0.046	1000.0	-1000.0	-0.031	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	0.016	0.036	1000.0	-1000.0	-0.027	-1000.0
Canonical NF-kappaB pathway	0.0	23.0	39.0	-0.014	0.051	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class II	0.0	22.0	75.0	-0.015	0.065	1000.0	-1000.0	-0.027	-1000.0
BARD1 signaling events	0.0	35.0	57.0	-0.047	0.062	1000.0	-1000.0	-0.039	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.011	-1000.0	1000.0	-1000.0	-0.018	-1000.0
Circadian rhythm pathway	0.0	5.0	22.0	-0.008	0.054	1000.0	-1000.0	-0.028	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	61.0	65.0	-0.124	0.043	1000.0	-1000.0	-0.049	-1000.0
Arf6 downstream pathway	0.0	14.0	43.0	-0.031	0.041	1000.0	-1000.0	-0.02	-1000.0
Aurora C signaling	0.0	0.0	7.0	0.0	0.04	1000.0	-1000.0	-0.01	-1000.0
EPO signaling pathway	0.0	27.0	55.0	0.011	0.062	1000.0	-1000.0	-0.048	-1000.0
mTOR signaling pathway	0.0	50.0	53.0	-0.069	0.033	1000.0	-1000.0	-0.037	-1000.0
TRAIL signaling pathway	0.0	38.0	48.0	-0.035	0.047	1000.0	-1000.0	-0.039	-1000.0
ceramide signaling pathway	0.0	39.0	49.0	0.0	0.036	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class I	0.0	20.0	104.0	-0.047	0.059	1000.0	-1000.0	-0.036	-1000.0
FoxO family signaling	0.0	57.0	64.0	-0.064	0.094	1000.0	-1000.0	-0.069	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	11.0	36.0	-0.045	0.047	1000.0	-1000.0	-0.037	-1000.0
IL2 signaling events mediated by PI3K	0.0	33.0	58.0	-0.012	0.052	1000.0	-1000.0	-0.059	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	34.0	45.0	-0.001	0.061	1000.0	-1000.0	-0.054	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	59.0	74.0	-0.06	0.056	1000.0	-1000.0	-0.064	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	59.0	76.0	-0.005	0.092	1000.0	-1000.0	-0.058	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	0.0	0.047	1000.0	-1000.0	-0.036	-1000.0
IL2 signaling events mediated by STAT5	0.0	6.0	22.0	-0.001	0.044	1000.0	-1000.0	-0.055	-1000.0
Arf6 trafficking events	0.0	53.0	71.0	-0.042	0.043	1000.0	-1000.0	-0.034	-1000.0
IGF1 pathway	0.0	56.0	57.0	-0.016	0.048	1000.0	-1000.0	-0.047	-1000.0
Insulin Pathway	0.0	43.0	74.0	-0.034	0.082	1000.0	-1000.0	-0.048	-1000.0
Rapid glucocorticoid signaling	0.0	15.0	20.0	-0.014	0.029	1000.0	-1000.0	-0.01	-1000.0
E-cadherin signaling in keratinocytes	0.0	10.0	43.0	-0.049	0.076	1000.0	-1000.0	-0.039	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.023	0.023	1000.0	-1000.0	-0.002	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.023	0.045	1000.0	-1000.0	-0.003	-1000.0
Arf1 pathway	0.0	53.0	54.0	-0.001	0.043	1000.0	-1000.0	-0.02	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.063	1000.0	-1000.0	-0.005	-1000.0
Total	427	26981	7203	-16.7683978601	-992.550334516	131000	-131000	-5.86293363534	-131000