Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.008 0.063 -9999.0 0.0 -0.209 6.0 6.0 epithelial cell differentiation -0.015 0.069 -9999.0 0.0 -0.211 6.0 6.0 CYFIP2 -0.025 0.111 -9999.0 0.0 -0.298 9.0 9.0 ENAH 0.01 0.051 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.017 0.107 -9999.0 0.0 -0.358 6.0 6.0 EPHA2 0.007 0.031 -9999.0 0.0 -0.177 2.0 2.0 MYO6 -0.012 0.065 -9999.0 0.0 -0.198 6.0 6.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.003 0.067 -9999.0 0.0 -0.258 4.0 4.0 AQP5 -0.056 0.148 -9999.0 0.0 -0.45 8.0 8.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.012 0.064 -9999.0 0.0 -0.195 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.073 -9999.0 0.0 -0.197 8.0 8.0 EGF -0.097 0.183 -9999.0 0.0 -0.371 21.0 21.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.015 0.093 -9999.0 0.0 -0.434 2.0 2.0 cortical microtubule organization -0.015 0.069 -9999.0 0.0 -0.211 6.0 6.0 GO:0000145 -0.012 0.06 -9999.0 0.0 -0.187 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.013 0.071 -9999.0 0.0 -0.213 6.0 6.0 MLLT4 0.006 0.053 -9999.0 0.0 -0.449 1.0 1.0 ARF6/GDP -0.024 0.048 -9999.0 0.0 -0.225 1.0 1.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.026 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.019 0.078 -9999.0 0.0 -0.325 2.0 2.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.012 0.065 -9999.0 0.0 -0.198 6.0 6.0 ARF6/GTP 0.029 0.023 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.074 0.137 -9999.0 0.0 -0.243 25.0 25.0 EGFR/EGFR/EGF/EGF -0.083 0.106 -9999.0 0.0 -0.231 22.0 22.0 RhoA/GDP -0.011 0.064 -9999.0 0.0 -0.196 6.0 6.0 actin cytoskeleton organization -0.008 0.063 -9999.0 0.0 -0.191 6.0 6.0 IGF-1R heterotetramer -0.009 0.092 -9999.0 0.0 -0.381 4.0 4.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.009 0.093 -9999.0 0.0 -0.381 4.0 4.0 IGF1 -0.045 0.12 -9999.0 0.0 -0.241 17.0 17.0 DIAPH1 -0.024 0.129 -9999.0 0.0 -0.565 4.0 4.0 Wnt receptor signaling pathway 0.015 0.069 0.211 6.0 -9999.0 0.0 6.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.024 0.048 -9999.0 0.0 -0.226 1.0 1.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.008 0.064 -9999.0 0.0 -0.195 6.0 6.0 EFNA1 0.005 0.037 -9999.0 0.0 -0.177 3.0 3.0 LPP -0.031 0.091 -9999.0 0.0 -0.255 6.0 6.0 Ephrin A1/EPHA2 -0.031 0.057 -9999.0 0.0 -0.199 6.0 6.0 SEC6/SEC8 -0.025 0.049 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.023 0.074 -9999.0 0.0 -0.2 8.0 8.0 HGF/MET -0.056 0.093 -9999.0 0.0 -0.241 12.0 12.0 HGF -0.03 0.114 -9999.0 0.0 -0.276 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.008 0.064 -9999.0 0.0 -0.21 6.0 6.0 actin cable formation 0.008 0.061 -9999.0 0.0 -0.23 1.0 1.0 KIAA1543 -0.022 0.073 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 -0.015 0.068 -9999.0 0.0 -0.198 7.0 7.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.027 0.093 -9999.0 0.0 -0.246 9.0 9.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.015 0.069 -9999.0 0.0 -0.211 6.0 6.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.012 0.065 -9999.0 0.0 -0.198 6.0 6.0 PIP5K1C -0.012 0.065 -9999.0 0.0 -0.198 6.0 6.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.006 0.057 -9999.0 0.0 -0.2 1.0 1.0 adherens junction assembly -0.013 0.079 -9999.0 0.0 -0.26 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.055 0.075 -9999.0 0.0 -0.244 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.014 0.038 -9999.0 0.0 -0.313 1.0 1.0 MET -0.02 0.108 -9999.0 0.0 -0.333 7.0 7.0 PLEKHA7 -0.019 0.072 -9999.0 0.0 -0.198 8.0 8.0 mol:GTP 0.025 0.024 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.004 0.061 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.008 0.063 -9999.0 0.0 -0.209 6.0 6.0 regulation of cell-cell adhesion -0.008 0.063 -9999.0 0.0 -0.191 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.008 0.064 -9999.0 0.0 -0.21 6.0 6.0