E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.027 0.132 -9999.0 0.0 -0.298 13.0 13.0 KLHL20 -0.016 0.092 0.169 2.0 -0.204 7.0 9.0 CYFIP2 0.012 0.069 -9999.0 0.0 -0.325 3.0 3.0 Rac1/GDP 0.011 0.098 0.242 3.0 -0.232 2.0 5.0 ENAH -0.031 0.135 -9999.0 0.0 -0.292 15.0 15.0 AP1M1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.008 0.051 0.127 1.0 -0.164 2.0 3.0 ABI1/Sra1/Nap1 -0.035 0.047 -9999.0 0.0 -0.132 8.0 8.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.04 0.077 -9999.0 0.0 -0.181 7.0 7.0 RAPGEF1 -0.019 0.122 0.216 3.0 -0.265 12.0 15.0 CTNND1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.027 0.142 -9999.0 0.0 -0.292 16.0 16.0 CRK -0.019 0.118 -9999.0 0.0 -0.281 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.028 0.075 -9999.0 0.0 -0.195 7.0 7.0 alphaE/beta7 Integrin 0.033 0.035 -9999.0 0.0 -0.228 1.0 1.0 IQGAP1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.042 0.034 -9999.0 0.0 -0.175 1.0 1.0 DLG1 -0.033 0.138 -9999.0 0.0 -0.289 16.0 16.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.019 0.03 -9999.0 0.0 -0.129 2.0 2.0 MLLT4 0.024 0.041 -9999.0 0.0 -0.325 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.04 0.054 -9999.0 0.0 -0.176 4.0 4.0 PI3K -0.023 0.039 -9999.0 0.0 -0.162 2.0 2.0 ARF6 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.002 0.077 -9999.0 0.0 -0.228 7.0 7.0 TIAM1 0.01 0.08 -9999.0 0.0 -0.325 4.0 4.0 E-cadherin(dimer)/Ca2+ 0.041 0.067 -9999.0 0.0 -0.169 6.0 6.0 AKT1 -0.004 0.042 0.102 2.0 -9999.0 0.0 2.0 PIK3R1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.01 0.094 -9999.0 0.0 -0.325 6.0 6.0 RhoA/GDP 0.01 0.101 0.242 3.0 -0.232 2.0 5.0 actin cytoskeleton organization -0.01 0.07 0.139 2.0 -0.149 7.0 9.0 CDC42/GDP 0.01 0.101 0.242 3.0 -0.232 2.0 5.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.004 0.063 -9999.0 0.0 -0.185 7.0 7.0 ITGB7 0.023 0.041 -9999.0 0.0 -0.325 1.0 1.0 RAC1 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.045 0.072 -9999.0 0.0 -0.18 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.028 0.06 -9999.0 0.0 -0.163 6.0 6.0 mol:GDP -0.004 0.104 0.244 3.0 -0.261 2.0 5.0 CDC42/GTP/IQGAP1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.041 -9999.0 0.0 -0.325 1.0 1.0 p120 catenin/RhoA/GDP 0.018 0.105 0.246 3.0 -0.238 2.0 5.0 RAC1/GTP/IQGAP1 0.035 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.019 0.07 0.092 1.0 -0.147 14.0 15.0 NME1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.034 0.137 -9999.0 0.0 -0.292 15.0 15.0 regulation of cell-cell adhesion -0.014 0.037 -9999.0 0.0 -0.146 2.0 2.0 WASF2 -0.01 0.039 0.087 2.0 -0.085 2.0 4.0 Rap1/GTP 0.011 0.059 0.176 2.0 -0.177 2.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.044 0.083 -9999.0 0.0 -0.172 8.0 8.0 CCND1 -0.024 0.085 -9999.0 0.0 -0.181 14.0 14.0 VAV2 -0.038 0.173 -9999.0 0.0 -0.57 3.0 3.0 RAP1/GDP 0.011 0.069 0.212 1.0 -0.189 2.0 3.0 adherens junction assembly -0.032 0.134 -9999.0 0.0 -0.285 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.027 0.073 -9999.0 0.0 -0.169 8.0 8.0 E-cadherin/beta catenin -0.002 0.076 -9999.0 0.0 -0.277 5.0 5.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.034 0.138 -9999.0 0.0 -0.294 15.0 15.0 PIK3CA 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.062 0.111 -9999.0 0.0 -0.318 7.0 7.0 E-cadherin/beta catenin/alpha catenin 0.032 0.071 -9999.0 0.0 -0.195 6.0 6.0 ITGAE 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.028 0.144 -9999.0 0.0 -0.298 16.0 16.0