E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.097 0.186 0.229 1.0 -0.368 82.0 83.0 KLHL20 -0.032 0.093 0.186 3.0 -0.221 23.0 26.0 CYFIP2 0.015 0.069 -9999.0 0.0 -0.327 10.0 10.0 Rac1/GDP -0.046 0.118 0.209 3.0 -0.233 59.0 62.0 ENAH -0.093 0.182 0.223 1.0 -0.377 72.0 73.0 AP1M1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.019 0.083 0.14 1.0 -0.159 54.0 55.0 ABI1/Sra1/Nap1 -0.041 0.055 -9999.0 0.0 -0.149 28.0 28.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.008 0.119 -9999.0 0.0 -0.182 80.0 80.0 RAPGEF1 -0.08 0.165 0.22 3.0 -0.34 68.0 71.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.094 0.194 -9999.0 0.0 -0.375 84.0 84.0 CRK -0.087 0.175 0.215 1.0 -0.354 75.0 76.0 E-cadherin/gamma catenin/alpha catenin -0.012 0.115 -9999.0 0.0 -0.197 72.0 72.0 alphaE/beta7 Integrin 0.027 0.058 -9999.0 0.0 -0.224 13.0 13.0 IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.044 0.028 -9999.0 0.0 -0.162 2.0 2.0 DLG1 -0.096 0.185 -9999.0 0.0 -0.367 83.0 83.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.041 0.048 -9999.0 0.0 -0.124 55.0 55.0 MLLT4 0.023 0.032 -9999.0 0.0 -0.327 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.04 0.052 -9999.0 0.0 -0.172 14.0 14.0 PI3K -0.05 0.061 -9999.0 0.0 -0.156 55.0 55.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.03 0.126 -9999.0 0.0 -0.233 72.0 72.0 TIAM1 0.01 0.08 -9999.0 0.0 -0.327 14.0 14.0 E-cadherin(dimer)/Ca2+ 0.002 0.104 -9999.0 0.0 -0.165 72.0 72.0 AKT1 -0.026 0.048 0.113 3.0 -0.133 2.0 5.0 PIK3R1 0.025 0.031 -9999.0 0.0 -0.327 2.0 2.0 CDH1 -0.064 0.162 -9999.0 0.0 -0.327 72.0 72.0 RhoA/GDP -0.044 0.127 0.242 5.0 -0.232 64.0 69.0 actin cytoskeleton organization -0.022 0.072 0.164 4.0 -0.161 23.0 27.0 CDC42/GDP -0.046 0.126 0.242 5.0 -0.232 64.0 69.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.039 0.097 -9999.0 0.0 -0.192 74.0 74.0 ITGB7 0.011 0.077 -9999.0 0.0 -0.327 13.0 13.0 RAC1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.003 0.112 -9999.0 0.0 -0.176 72.0 72.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.008 0.095 -9999.0 0.0 -0.161 72.0 72.0 mol:GDP -0.063 0.134 0.245 5.0 -0.262 64.0 69.0 CDC42/GTP/IQGAP1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.034 0.12 5.0 -0.327 2.0 7.0 p120 catenin/RhoA/GDP -0.04 0.13 0.23 4.0 -0.238 61.0 65.0 RAC1/GTP/IQGAP1 0.033 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.012 0.056 0.145 6.0 -0.115 19.0 25.0 NME1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.099 0.187 -9999.0 0.0 -0.371 83.0 83.0 regulation of cell-cell adhesion -0.025 0.067 -9999.0 0.0 -0.142 54.0 54.0 WASF2 -0.015 0.04 0.094 2.0 -0.09 12.0 14.0 Rap1/GTP -0.019 0.095 0.232 4.0 -0.173 52.0 56.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.0 0.121 -9999.0 0.0 -0.178 78.0 78.0 CCND1 -0.015 0.066 0.165 6.0 -0.139 20.0 26.0 VAV2 -0.122 0.249 0.359 1.0 -0.652 27.0 28.0 RAP1/GDP -0.025 0.107 0.265 3.0 -0.237 7.0 10.0 adherens junction assembly -0.096 0.182 -9999.0 0.0 -0.36 83.0 83.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.011 0.112 0.244 1.0 -0.174 78.0 79.0 E-cadherin/beta catenin -0.065 0.131 -9999.0 0.0 -0.281 71.0 71.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.094 0.183 0.224 1.0 -0.37 77.0 78.0 PIK3CA 0.024 0.038 -9999.0 0.0 -0.327 3.0 3.0 Rac1/GTP -0.075 0.127 -9999.0 0.0 -0.349 26.0 26.0 E-cadherin/beta catenin/alpha catenin -0.011 0.112 -9999.0 0.0 -0.192 72.0 72.0 ITGAE 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.096 0.198 -9999.0 0.0 -0.383 84.0 84.0