Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.016 0.123 0.295 1.0 -0.462 14.0 15.0 IHH 0.032 0.053 0.143 5.0 -0.134 19.0 24.0 SHH Np/Cholesterol/GAS1 0.016 0.029 -9999.0 0.0 -0.175 5.0 5.0 LRPAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.015 0.029 0.174 5.0 -9999.0 0.0 5.0 SMO/beta Arrestin2 0.007 0.136 -9999.0 0.0 -0.369 15.0 15.0 SMO -0.016 0.126 -9999.0 0.0 -0.386 16.0 16.0 AKT1 -0.002 0.104 -9999.0 0.0 -0.38 11.0 11.0 ARRB2 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.072 -9999.0 0.0 -0.327 10.0 10.0 ADRBK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.015 0.124 -9999.0 0.0 -0.381 16.0 16.0 STIL 0.021 0.091 0.189 33.0 -0.236 15.0 48.0 DHH N/PTCH2 0.035 0.069 0.175 2.0 -0.228 15.0 17.0 DHH N/PTCH1 0.023 0.113 0.205 1.0 -0.324 20.0 21.0 PIK3CA 0.024 0.038 -9999.0 0.0 -0.327 3.0 3.0 DHH 0.023 0.078 -9999.0 0.0 -0.327 11.0 11.0 PTHLH -0.004 0.181 0.299 1.0 -0.611 19.0 20.0 determination of left/right symmetry -0.015 0.124 -9999.0 0.0 -0.381 16.0 16.0 PIK3R1 0.025 0.031 -9999.0 0.0 -0.327 2.0 2.0 skeletal system development -0.003 0.179 0.298 1.0 -0.605 19.0 20.0 IHH N/Hhip 0.044 0.042 0.183 3.0 -9999.0 0.0 3.0 DHH N/Hhip 0.039 0.063 0.175 4.0 -0.229 11.0 15.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.015 0.124 -9999.0 0.0 -0.381 16.0 16.0 pancreas development 0.031 0.025 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.019 0.049 -9999.0 0.0 -0.327 5.0 5.0 PI3K 0.035 0.041 -9999.0 0.0 -0.275 4.0 4.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.023 0.039 0.12 1.0 -0.327 3.0 4.0 somite specification -0.015 0.124 -9999.0 0.0 -0.381 16.0 16.0 SHH Np/Cholesterol/PTCH1 0.009 0.071 -9999.0 0.0 -0.243 15.0 15.0 SHH Np/Cholesterol/PTCH2 0.018 0.035 0.156 2.0 -0.176 6.0 8.0 SHH Np/Cholesterol/Megalin -0.008 0.105 0.199 10.0 -0.177 64.0 74.0 SHH -0.012 0.027 -9999.0 0.0 -0.232 3.0 3.0 catabolic process 0.01 0.105 -9999.0 0.0 -0.354 19.0 19.0 SMO/Vitamin D3 0.006 0.104 0.22 14.0 -0.29 17.0 31.0 SHH Np/Cholesterol/Hhip 0.015 0.038 0.156 6.0 -0.173 3.0 9.0 LRP2 -0.048 0.18 0.12 74.0 -0.327 76.0 150.0 receptor-mediated endocytosis -0.033 0.128 0.224 4.0 -0.323 27.0 31.0 SHH Np/Cholesterol/BOC 0.016 0.047 0.2 1.0 -0.191 10.0 11.0 SHH Np/Cholesterol/CDO 0.014 0.036 -9999.0 0.0 -0.201 6.0 6.0 mesenchymal cell differentiation -0.015 0.037 0.172 3.0 -0.154 6.0 9.0 mol:Vitamin D3 0.037 0.1 0.217 35.0 -0.244 15.0 50.0 IHH N/PTCH2 0.038 0.052 0.197 1.0 -0.245 4.0 5.0 CDON 0.021 0.044 -9999.0 0.0 -0.327 4.0 4.0 IHH N/PTCH1 0.021 0.111 0.227 1.0 -0.347 20.0 21.0 Megalin/LRPAP1 -0.019 0.135 -9999.0 0.0 -0.228 76.0 76.0 PTCH2 0.025 0.046 -9999.0 0.0 -0.327 4.0 4.0 SHH Np/Cholesterol 0.01 0.021 -9999.0 0.0 -0.172 3.0 3.0 PTCH1 0.01 0.106 -9999.0 0.0 -0.355 19.0 19.0 HHIP 0.031 0.025 -9999.0 0.0 -9999.0 0.0 0.0