Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.033 0.094 -9999.0 0.0 -0.185 73.0 73.0 epithelial cell differentiation -0.002 0.101 -9999.0 0.0 -0.164 72.0 72.0 CYFIP2 0.015 0.069 -9999.0 0.0 -0.327 10.0 10.0 ENAH -0.047 0.066 0.266 1.0 -0.234 4.0 5.0 EGFR 0.024 0.063 -9999.0 0.0 -0.327 7.0 7.0 EPHA2 0.022 0.055 0.12 5.0 -0.327 6.0 11.0 MYO6 -0.05 0.079 0.211 5.0 -0.164 72.0 77.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.05 -9999.0 0.0 -0.188 10.0 10.0 AQP5 -0.027 0.093 0.427 1.0 -0.431 5.0 6.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.047 0.075 0.209 5.0 -0.158 69.0 74.0 regulation of calcium-dependent cell-cell adhesion -0.044 0.08 0.221 5.0 -0.163 63.0 68.0 EGF -0.027 0.141 0.12 22.0 -0.327 47.0 69.0 NCKAP1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.052 0.119 0.384 1.0 -0.345 25.0 26.0 cortical microtubule organization -0.002 0.101 -9999.0 0.0 -0.164 72.0 72.0 GO:0000145 -0.046 0.07 0.197 5.0 -0.151 69.0 74.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.002 0.104 -9999.0 0.0 -0.165 72.0 72.0 MLLT4 0.023 0.032 -9999.0 0.0 -0.327 2.0 2.0 ARF6/GDP -0.055 0.06 -9999.0 0.0 -0.156 61.0 61.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.058 0.046 -9999.0 0.0 -0.173 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.035 0.069 0.211 4.0 -9999.0 0.0 4.0 PVRL2 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.044 0.073 0.217 4.0 -0.16 62.0 66.0 ARF6/GTP 0.063 0.048 -9999.0 0.0 -0.164 6.0 6.0 CDH1 -0.064 0.162 -9999.0 0.0 -0.327 72.0 72.0 EGFR/EGFR/EGF/EGF -0.037 0.12 -9999.0 0.0 -0.183 98.0 98.0 RhoA/GDP -0.0 0.099 -9999.0 0.0 -0.159 72.0 72.0 actin cytoskeleton organization -0.054 0.078 0.194 5.0 -0.168 62.0 67.0 IGF-1R heterotetramer 0.025 0.031 -9999.0 0.0 -0.326 2.0 2.0 GIT1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.031 -9999.0 0.0 -0.327 2.0 2.0 IGF1 0.008 0.089 0.12 6.0 -0.327 17.0 23.0 DIAPH1 -0.032 0.214 -9999.0 0.0 -0.535 37.0 37.0 Wnt receptor signaling pathway 0.002 0.101 0.164 72.0 -9999.0 0.0 72.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.056 0.06 -9999.0 0.0 -0.157 61.0 61.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.055 0.08 0.196 5.0 -0.171 62.0 67.0 EFNA1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.052 0.073 0.203 5.0 -9999.0 0.0 5.0 Ephrin A1/EPHA2 -0.009 0.092 -9999.0 0.0 -0.159 69.0 69.0 SEC6/SEC8 -0.049 0.061 -9999.0 0.0 -0.155 64.0 64.0 MGAT3 -0.044 0.081 0.223 5.0 -0.165 63.0 68.0 HGF/MET -0.023 0.11 -9999.0 0.0 -0.175 84.0 84.0 HGF 0.016 0.075 0.12 14.0 -0.327 11.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.033 0.095 -9999.0 0.0 -0.186 73.0 73.0 actin cable formation -0.016 0.106 0.257 16.0 -0.259 6.0 22.0 KIAA1543 -0.049 0.075 0.199 5.0 -0.157 70.0 75.0 KIFC3 -0.05 0.073 0.236 3.0 -0.16 70.0 73.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.049 0.077 0.211 5.0 -0.16 72.0 77.0 NCK1/GIT1 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.002 0.101 -9999.0 0.0 -0.164 72.0 72.0 EXOC4 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.048 0.076 0.211 5.0 -0.16 70.0 75.0 PIP5K1C -0.047 0.076 0.211 5.0 -0.16 69.0 74.0 LIMA1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.035 0.096 0.445 3.0 -0.236 1.0 4.0 adherens junction assembly -0.046 0.088 0.32 2.0 -0.313 7.0 9.0 IGF-1R heterotetramer/IGF1 -0.018 0.105 -9999.0 0.0 -0.167 83.0 83.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.035 0.027 -9999.0 0.0 -0.228 2.0 2.0 MET -0.002 0.102 -9999.0 0.0 -0.327 23.0 23.0 PLEKHA7 -0.05 0.08 0.211 5.0 -0.164 70.0 75.0 mol:GTP 0.056 0.045 -9999.0 0.0 -0.172 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.02 0.108 0.254 13.0 -9999.0 0.0 13.0 cortical actin cytoskeleton stabilization -0.033 0.094 -9999.0 0.0 -0.185 73.0 73.0 regulation of cell-cell adhesion -0.054 0.078 0.194 5.0 -0.168 62.0 67.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.033 0.095 -9999.0 0.0 -0.186 73.0 73.0