Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	54.0	382.0	7.0	-0.051	-0.0	1000.0	-1000.0	-0.0	-1000.0
TCR signaling in naïve CD8+ T cells	44.0	4136.0	93.0	-0.226	0.114	1000.0	-1000.0	-0.028	-1000.0
E-cadherin signaling events	44.0	223.0	5.0	-0.064	0.029	1000.0	-1000.0	0.019	-1000.0
IL4-mediated signaling events	38.0	3485.0	91.0	-0.504	0.366	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	38.0	3014.0	78.0	-0.195	0.063	1000.0	-1000.0	-0.028	-1000.0
IL23-mediated signaling events	37.0	2226.0	60.0	-0.313	0.029	1000.0	-1000.0	-0.063	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	36.0	2728.0	74.0	-0.064	0.063	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling in the nascent adherens junction	34.0	2588.0	76.0	-0.122	0.044	1000.0	-1000.0	-0.038	-1000.0
Signaling events regulated by Ret tyrosine kinase	33.0	2719.0	82.0	-0.053	0.032	1000.0	-1000.0	-0.029	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	33.0	2298.0	68.0	-0.306	0.087	1000.0	-1000.0	-0.044	-1000.0
Angiopoietin receptor Tie2-mediated signaling	33.0	2971.0	88.0	-0.203	0.037	1000.0	-1000.0	-0.049	-1000.0
Endothelins	32.0	3121.0	96.0	-0.122	0.051	1000.0	-1000.0	-0.029	-1000.0
IL12-mediated signaling events	31.0	2781.0	87.0	-0.298	0.061	1000.0	-1000.0	-0.045	-1000.0
Syndecan-1-mediated signaling events	30.0	1044.0	34.0	-0.051	0.029	1000.0	-1000.0	-0.014	-1000.0
BCR signaling pathway	30.0	3067.0	99.0	-0.157	0.034	1000.0	-1000.0	-0.066	-1000.0
E-cadherin signaling in keratinocytes	28.0	1232.0	43.0	-0.068	0.031	1000.0	-1000.0	-0.015	-1000.0
Nectin adhesion pathway	27.0	1721.0	63.0	-0.093	0.044	1000.0	-1000.0	-0.025	-1000.0
Thromboxane A2 receptor signaling	24.0	2522.0	105.0	-0.087	0.034	1000.0	-1000.0	-0.026	-1000.0
LPA receptor mediated events	24.0	2524.0	102.0	-0.082	0.032	1000.0	-1000.0	-0.043	-1000.0
TCGA08_retinoblastoma	24.0	195.0	8.0	-0.007	0.048	1000.0	-1000.0	-0.005	-1000.0
Glypican 1 network	23.0	1121.0	48.0	-0.042	0.039	1000.0	-1000.0	-0.018	-1000.0
Signaling mediated by p38-alpha and p38-beta	23.0	1014.0	44.0	-0.059	0.029	1000.0	-1000.0	-0.011	-1000.0
Integrins in angiogenesis	23.0	1935.0	84.0	-0.107	0.052	1000.0	-1000.0	-0.018	-1000.0
EPHB forward signaling	23.0	1989.0	85.0	-0.051	0.059	1000.0	-1000.0	-0.041	-1000.0
Glucocorticoid receptor regulatory network	22.0	2541.0	114.0	-0.242	0.126	1000.0	-1000.0	-0.034	-1000.0
FAS signaling pathway (CD95)	22.0	1076.0	47.0	-0.026	0.037	1000.0	-1000.0	-0.025	-1000.0
IL27-mediated signaling events	22.0	1138.0	51.0	-0.158	0.101	1000.0	-1000.0	-0.036	-1000.0
Wnt signaling	22.0	157.0	7.0	-0.026	0.023	1000.0	-1000.0	-0.001	-1000.0
EGFR-dependent Endothelin signaling events	22.0	471.0	21.0	-0.036	0.041	1000.0	-1000.0	-0.026	-1000.0
Caspase cascade in apoptosis	21.0	1557.0	74.0	-0.062	0.038	1000.0	-1000.0	-0.033	-1000.0
Osteopontin-mediated events	21.0	809.0	38.0	-0.047	0.031	1000.0	-1000.0	-0.021	-1000.0
p75(NTR)-mediated signaling	21.0	2669.0	125.0	-0.053	0.072	1000.0	-1000.0	-0.038	-1000.0
S1P4 pathway	21.0	536.0	25.0	-0.034	0.037	1000.0	-1000.0	-0.015	-1000.0
BMP receptor signaling	20.0	1652.0	81.0	-0.054	0.05	1000.0	-1000.0	-0.013	-1000.0
Calcium signaling in the CD4+ TCR pathway	20.0	646.0	31.0	-0.089	0.029	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	19.0	326.0	17.0	-0.085	0.038	1000.0	-1000.0	-0.025	-1000.0
Noncanonical Wnt signaling pathway	19.0	498.0	26.0	-0.035	0.028	1000.0	-1000.0	-0.026	-1000.0
Arf6 signaling events	19.0	1182.0	62.0	-0.028	0.058	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by PTP1B	19.0	1446.0	76.0	-0.055	0.043	1000.0	-1000.0	-0.04	-1000.0
Glypican 2 network	19.0	77.0	4.0	0.011	0.014	1000.0	-1000.0	0.019	-1000.0
Plasma membrane estrogen receptor signaling	19.0	1645.0	86.0	-0.124	0.093	1000.0	-1000.0	-0.03	-1000.0
Class IB PI3K non-lipid kinase events	19.0	57.0	3.0	-0.008	0.008	1000.0	-1000.0	-0.022	-1000.0
HIF-1-alpha transcription factor network	18.0	1410.0	76.0	-0.019	0.068	1000.0	-1000.0	-0.018	-1000.0
a4b1 and a4b7 Integrin signaling	18.0	94.0	5.0	0.0	0.019	1000.0	-1000.0	0.02	-1000.0
Fc-epsilon receptor I signaling in mast cells	18.0	1789.0	97.0	-0.046	0.05	1000.0	-1000.0	-0.062	-1000.0
Ephrin B reverse signaling	18.0	867.0	48.0	-0.053	0.04	1000.0	-1000.0	-0.029	-1000.0
Syndecan-4-mediated signaling events	18.0	1219.0	67.0	-0.046	0.037	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by the Hedgehog family	17.0	886.0	52.0	-0.048	0.044	1000.0	-1000.0	-0.017	-1000.0
IFN-gamma pathway	17.0	1191.0	68.0	-0.034	0.037	1000.0	-1000.0	-0.031	-1000.0
Ceramide signaling pathway	17.0	1344.0	76.0	-0.036	0.047	1000.0	-1000.0	-0.019	-1000.0
TRAIL signaling pathway	17.0	855.0	48.0	-0.026	0.044	1000.0	-1000.0	-0.024	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	17.0	794.0	45.0	-0.05	0.059	1000.0	-1000.0	-0.029	-1000.0
Reelin signaling pathway	16.0	947.0	56.0	-0.025	0.059	1000.0	-1000.0	-0.013	-1000.0
S1P5 pathway	16.0	287.0	17.0	-0.034	0.034	1000.0	-1000.0	-0.003	-1000.0
IL2 signaling events mediated by PI3K	16.0	950.0	58.0	-0.095	0.042	1000.0	-1000.0	-0.03	-1000.0
Effects of Botulinum toxin	16.0	432.0	26.0	-0.019	0.042	1000.0	-1000.0	-0.001	-1000.0
Class I PI3K signaling events	16.0	1190.0	73.0	-0.096	0.051	1000.0	-1000.0	-0.022	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	15.0	1352.0	85.0	-0.029	0.04	1000.0	-1000.0	-0.035	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	15.0	781.0	52.0	-0.054	0.058	1000.0	-1000.0	-0.029	-1000.0
Ras signaling in the CD4+ TCR pathway	15.0	260.0	17.0	-0.025	0.051	1000.0	-1000.0	-0.014	-1000.0
amb2 Integrin signaling	14.0	1194.0	82.0	-0.032	0.043	1000.0	-1000.0	-0.019	-1000.0
LPA4-mediated signaling events	13.0	159.0	12.0	-0.042	0.006	1000.0	-1000.0	-0.015	-1000.0
Syndecan-2-mediated signaling events	13.0	900.0	69.0	-0.016	0.043	1000.0	-1000.0	-0.029	-1000.0
IL1-mediated signaling events	13.0	832.0	62.0	-0.03	0.07	1000.0	-1000.0	-0.024	-1000.0
ceramide signaling pathway	13.0	652.0	49.0	-0.029	0.041	1000.0	-1000.0	-0.029	-1000.0
Signaling mediated by p38-gamma and p38-delta	13.0	200.0	15.0	-0.019	0.027	1000.0	-1000.0	-0.019	-1000.0
ErbB2/ErbB3 signaling events	12.0	842.0	65.0	-0.03	0.041	1000.0	-1000.0	-0.044	-1000.0
EPO signaling pathway	12.0	664.0	55.0	-0.001	0.049	1000.0	-1000.0	-0.02	-1000.0
S1P1 pathway	12.0	459.0	36.0	-0.071	0.028	1000.0	-1000.0	-0.021	-1000.0
TCGA08_p53	12.0	88.0	7.0	-0.012	0.024	1000.0	-1000.0	-0.003	-1000.0
IL2 signaling events mediated by STAT5	12.0	276.0	22.0	-0.04	0.029	1000.0	-1000.0	-0.012	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	12.0	1557.0	120.0	-0.079	0.069	1000.0	-1000.0	-0.033	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	11.0	608.0	54.0	-0.017	0.04	1000.0	-1000.0	-0.016	-1000.0
IGF1 pathway	11.0	659.0	57.0	-0.027	0.059	1000.0	-1000.0	-0.02	-1000.0
PDGFR-beta signaling pathway	11.0	1082.0	97.0	-0.056	0.064	1000.0	-1000.0	-0.032	-1000.0
Regulation of Androgen receptor activity	11.0	789.0	70.0	-0.093	0.036	1000.0	-1000.0	-0.028	-1000.0
Regulation of nuclear SMAD2/3 signaling	10.0	1381.0	136.0	-0.296	0.073	1000.0	-1000.0	-0.032	-1000.0
Sphingosine 1-phosphate (S1P) pathway	10.0	288.0	28.0	-0.034	0.043	1000.0	-1000.0	-0.015	-1000.0
Cellular roles of Anthrax toxin	10.0	423.0	39.0	-0.029	0.028	1000.0	-1000.0	-0.016	-1000.0
FOXA2 and FOXA3 transcription factor networks	10.0	489.0	46.0	-0.15	0.036	1000.0	-1000.0	-0.044	-1000.0
PDGFR-alpha signaling pathway	10.0	471.0	44.0	-0.02	0.055	1000.0	-1000.0	-0.024	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	10.0	393.0	37.0	-0.032	0.047	1000.0	-1000.0	-0.017	-1000.0
Paxillin-dependent events mediated by a4b1	10.0	376.0	36.0	-0.037	0.047	1000.0	-1000.0	-0.029	-1000.0
Regulation of p38-alpha and p38-beta	10.0	554.0	54.0	-0.056	0.058	1000.0	-1000.0	-0.034	-1000.0
Rapid glucocorticoid signaling	10.0	202.0	20.0	-0.008	0.029	1000.0	-1000.0	-0.0	-1000.0
Presenilin action in Notch and Wnt signaling	9.0	570.0	61.0	-0.011	0.073	1000.0	-1000.0	-0.022	-1000.0
Atypical NF-kappaB pathway	9.0	288.0	31.0	-0.018	0.035	1000.0	-1000.0	-0.016	-1000.0
Canonical Wnt signaling pathway	9.0	495.0	51.0	-0.039	0.064	1000.0	-1000.0	-0.022	-1000.0
Nongenotropic Androgen signaling	9.0	490.0	52.0	-0.054	0.044	1000.0	-1000.0	-0.016	-1000.0
TCGA08_rtk_signaling	9.0	238.0	26.0	-0.021	0.063	1000.0	-1000.0	-0.011	-1000.0
IL6-mediated signaling events	9.0	690.0	75.0	-0.036	0.072	1000.0	-1000.0	-0.038	-1000.0
S1P3 pathway	9.0	396.0	42.0	-0.034	0.045	1000.0	-1000.0	-0.03	-1000.0
mTOR signaling pathway	8.0	450.0	53.0	-0.034	0.033	1000.0	-1000.0	-0.027	-1000.0
HIF-2-alpha transcription factor network	8.0	384.0	43.0	-0.108	0.11	1000.0	-1000.0	-0.034	-1000.0
Retinoic acid receptors-mediated signaling	8.0	488.0	58.0	-0.043	0.055	1000.0	-1000.0	-0.032	-1000.0
Insulin Pathway	8.0	605.0	74.0	-0.077	0.07	1000.0	-1000.0	-0.027	-1000.0
Visual signal transduction: Rods	8.0	457.0	52.0	-0.0	0.046	1000.0	-1000.0	-0.006	-1000.0
Coregulation of Androgen receptor activity	7.0	554.0	76.0	-0.064	0.048	1000.0	-1000.0	-0.017	-1000.0
Hedgehog signaling events mediated by Gli proteins	7.0	516.0	65.0	-0.049	0.067	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class III	7.0	312.0	40.0	-0.053	0.046	1000.0	-1000.0	-0.035	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	7.0	596.0	83.0	-0.032	0.053	1000.0	-1000.0	-0.009	-1000.0
Aurora B signaling	7.0	516.0	67.0	-0.073	0.064	1000.0	-1000.0	-0.038	-1000.0
ErbB4 signaling events	6.0	457.0	69.0	-0.068	0.064	1000.0	-1000.0	-0.02	-1000.0
Arf6 downstream pathway	6.0	264.0	43.0	-0.039	0.049	1000.0	-1000.0	-0.024	-1000.0
FoxO family signaling	6.0	422.0	64.0	-0.189	0.042	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	6.0	853.0	125.0	-0.015	0.067	1000.0	-1000.0	-0.019	-1000.0
Regulation of Telomerase	6.0	703.0	102.0	-0.084	0.058	1000.0	-1000.0	-0.03	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	225.0	33.0	-0.003	0.061	1000.0	-1000.0	-0.017	-1000.0
FOXM1 transcription factor network	6.0	322.0	51.0	-0.023	0.084	1000.0	-1000.0	-0.068	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	180.0	34.0	-0.041	0.071	1000.0	-1000.0	-0.029	-1000.0
PLK2 and PLK4 events	5.0	15.0	3.0	-0.018	-1000.0	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	5.0	208.0	38.0	-0.016	0.052	1000.0	-1000.0	-0.018	-1000.0
PLK1 signaling events	5.0	432.0	85.0	-0.007	0.049	1000.0	-1000.0	-0.024	-1000.0
Class I PI3K signaling events mediated by Akt	5.0	371.0	68.0	-0.039	0.051	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by PRL	5.0	202.0	34.0	-0.025	0.049	1000.0	-1000.0	-0.026	-1000.0
p38 MAPK signaling pathway	5.0	234.0	44.0	-0.038	0.047	1000.0	-1000.0	-0.009	-1000.0
Canonical NF-kappaB pathway	4.0	169.0	39.0	-0.007	0.059	1000.0	-1000.0	-0.014	-1000.0
BARD1 signaling events	4.0	246.0	57.0	-0.055	0.06	1000.0	-1000.0	-0.043	-1000.0
Aurora C signaling	4.0	30.0	7.0	-0.0	0.046	1000.0	-1000.0	-0.008	-1000.0
Insulin-mediated glucose transport	4.0	153.0	32.0	-0.014	0.049	1000.0	-1000.0	-0.017	-1000.0
Syndecan-3-mediated signaling events	4.0	167.0	35.0	-0.0	0.072	1000.0	-1000.0	-0.012	-1000.0
Aurora A signaling	3.0	202.0	60.0	-0.025	0.058	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class I	3.0	342.0	104.0	-0.053	0.067	1000.0	-1000.0	-0.033	-1000.0
VEGFR1 specific signals	3.0	190.0	56.0	-0.029	0.055	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by HDAC Class II	2.0	161.0	75.0	-0.03	0.071	1000.0	-1000.0	-0.02	-1000.0
Circadian rhythm pathway	2.0	49.0	22.0	-0.008	0.043	1000.0	-1000.0	-0.026	-1000.0
Arf6 trafficking events	2.0	197.0	71.0	-0.04	0.052	1000.0	-1000.0	-0.031	-1000.0
Arf1 pathway	2.0	117.0	54.0	-0.002	0.048	1000.0	-1000.0	-0.008	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	20.0	23.0	0.003	0.057	1000.0	-1000.0	-0.009	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	11.0	27.0	-0.011	0.068	1000.0	-1000.0	-0.021	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	-0.0	0.072	1000.0	-1000.0	-0.0	-1000.0
Total	1970	116695	7203	-8.08664616587	-993.208373953	131000	-131000	-3.16877128116	-131000