Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TRIM48	14 (6%)	205	0.23457	1	0.32224	1	0.028892	1	0.16405	1	0.37716	1	0.9249	1	0.4718	1	0.28016	1	0.093076	1	0.59687	1
PIK3CA	48 (22%)	171	5.4158e-05	0.0133	1.8289e-09	4.65e-07	0.011906	1	0.00047758	0.114	0.00081512	0.194	5.0511e-07	0.000128	0.017035	1	0.0054368	1	0.047823	1	0.00086479	0.205
PGM5	22 (10%)	197	0.0022281	0.51	4.2751e-05	0.0106	0.15908	1	0.060141	1	0.0026733	0.601	0.0045971	1	0.26377	1	0.024165	1	0.085654	1	0.13759	1
KRAS	25 (11%)	194	0.014549	1	0.12711	1	0.54101	1	0.96007	1	0.26185	1	0.051089	1	0.26187	1	0.18406	1	0.23327	1	0.94679	1
CBWD1	28 (13%)	191	9.5375e-05	0.0232	1.7942e-06	0.000452	5.2616e-05	0.013	0.0031193	0.699	0.0012216	0.286	0.0084421	1	0.03092	1	0.0023176	0.528	0.17774	1	0.002367	0.537
TP53	98 (45%)	121	9.4525e-11	2.41e-08	3.1827e-05	0.00792	0.20875	1	0.66719	1	0.00038234	0.0921	0.001633	0.377	0.0072252	1	5.0994e-06	0.00128	0.28587	1	0.00032469	0.0786
ARID1A	41 (19%)	178	6.1456e-05	0.0151	0.002617	0.591	0.012241	1	0.19017	1	0.00096967	0.229	1.8536e-05	0.00463	0.042258	1	0.039167	1	0.6794	1	0.29695	1
SMAD4	19 (9%)	200	0.94769	1	0.96329	1	0.05923	1	0.74697	1	0.033039	1	0.091377	1	0.40884	1	0.61843	1	0.24799	1	0.20104	1
RHOA	13 (6%)	206	0.15923	1	0.18936	1	0.87114	1	1	1	0.6231	1	0.23848	1	0.0016598	0.382	0.18527	1	0.0010551	0.248	0.12687	1
MXRA8	10 (5%)	209	0.15622	1	0.023186	1	0.27335	1	0.01176	1	0.0047931	1	0.098946	1	0.032224	1	0.010172	1	0.54107	1	0.12517	1
IRF2	15 (7%)	204	0.15773	1	0.23319	1	0.11806	1	0.58808	1	0.059027	1	0.19947	1	0.0078586	1	0.022084	1	0.085153	1	0.030887	1
CDH1	18 (8%)	201	0.21467	1	0.45846	1	0.61058	1	0.44342	1	0.048077	1	0.052946	1	0.016004	1	0.067463	1	0.05608	1	0.11399	1
PTEN	14 (6%)	205	0.016631	1	0.015187	1	0.0031864	0.711	0.019106	1	0.022164	1	0.0956	1	0.11481	1	0.022041	1	0.20674	1	0.012062	1
FBXW7	19 (9%)	200	0.031832	1	0.021979	1	0.0014347	0.334	0.0042825	0.938	0.0037784	0.839	0.94152	1	0.04675	1	0.0041224	0.907	0.0040217	0.889	0.0059633	1
B2M	8 (4%)	211	0.017514	1	0.023186	1	0.086009	1	0.41382	1	0.12996	1	0.6832	1	0.31418	1	0.15049	1	0.9069	1	0.12517	1
PTH2	4 (2%)	215	1	1	0.68655	1	1	1	0.8356	1	0.336	1	1	1	0.46701	1	1	1	0.82109	1	1	1
FAM46D	6 (3%)	213	0.54782	1	0.70832	1	0.74383	1	0.42524	1	0.15161	1	0.64047	1	0.87755	1	0.76558	1	1	1	0.71015	1
APC	33 (15%)	186	1	1	0.020711	1	0.062722	1	0.063144	1	0.17844	1	0.03102	1	0.00869	1	0.013558	1	0.062288	1	0.0014518	0.337
RNF43	9 (4%)	210	0.047844	1	0.59562	1	0.57641	1	0.18868	1	0.070778	1	0.52989	1	0.43498	1	0.18184	1	0.88134	1	0.41115	1
MAP2K7	14 (6%)	205	0.016631	1	0.098363	1	0.82205	1	0.8097	1	0.1911	1	0.86123	1	0.30768	1	0.085046	1	0.79056	1	0.46112	1
WSB2	7 (3%)	212	0.22393	1	0.13079	1	0.086009	1	0.079696	1	0.11451	1	0.20983	1	0.031871	1	0.0074191	1	0.25216	1	0.066641	1
BCOR	16 (7%)	203	0.0051818	1	6.6674e-05	0.0163	0.14745	1	0.010905	1	0.058269	1	0.023376	1	0.012871	1	0.00045257	0.109	0.27343	1	0.1509	1
TRPS1	30 (14%)	189	0.6701	1	0.039676	1	0.10595	1	0.1084	1	0.01576	1	0.55421	1	0.43735	1	0.41412	1	0.32651	1	0.23109	1
C13ORF33	6 (3%)	213	0.74927	1	0.016515	1	0.014652	1	0.1131	1	0.1105	1	0.68231	1	0.58919	1	0.33333	1	0.3242	1	0.41115	1
HRCT1	4 (2%)	215	0.29723	1	0.91494	1	NA	NA	NA	NA	0.34834	1	0.12306	1	0.10874	1	0.034056	1	0.3886	1	0.33202	1
IAPP	4 (2%)	215	0.3775	1	NA	NA	0.84386	1	0.53309	1	0.74247	1	0.21438	1	0.68847	1	0.82083	1	NA	NA	NA	NA