rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(8) 238419 8 8 8 0 3 1 1 1 2 0 0.0857 0.00207 1.000 2 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(5), FMOD(8), KERA(1), LUM(5) 1194047 20 19 20 4 10 4 1 5 0 0 0.132 0.315 1.000 3 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCL5(1), CCR3(6), HLA-DRA(6), IL3(1) 999988 15 14 15 3 8 5 0 2 0 0 0.131 0.432 1.000 4 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(1), TGDS(3), UGDH(5), UXS1(3) 1268853 13 12 13 1 4 5 1 2 1 0 0.0486 0.642 1.000 5 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(2), FOSB(3), GRIA2(17), JUND(1), PPP1R1B(1) 1225092 24 20 24 5 6 9 1 6 2 0 0.126 0.667 1.000 6 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(4), TPI1(1) 539342 5 5 5 1 2 2 1 0 0 0 0.358 0.730 1.000 7 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4), IL8(1), SLPI(1) 563163 6 5 6 2 3 2 0 1 0 0 0.495 0.768 1.000 8 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(3), GSTZ1(3), HGD(3) 730546 9 8 9 3 4 2 0 3 0 0 0.492 0.772 1.000 9 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL12A(2), IL12B(1), IL18(1) 980615 8 8 8 2 0 3 1 4 0 0 0.559 0.780 1.000 10 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2) 375013 2 2 2 1 0 1 1 0 0 0 0.822 0.789 1.000 11 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(1), TGDS(3), UGDH(5), UGP2(3), UXS1(3) 1614572 16 14 16 2 6 5 1 3 1 0 0.0632 0.876 1.000 12 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(8), GLS2(6), GLUD1(3), GLUD2(10) 1489756 27 20 27 6 6 8 0 12 1 0 0.205 0.884 1.000 13 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(5), AASS(6), KARS(5) 1553133 16 12 16 2 4 6 1 5 0 0 0.117 0.894 1.000 14 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8) 1855447 24 19 23 5 3 7 0 10 4 0 0.212 0.897 1.000 15 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP3(2), CASP8(8), CFL1(1) 1273104 13 12 13 3 3 4 1 4 1 0 0.380 0.898 1.000 16 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(3), ACAT2(3), OXCT1(6) 1112143 12 11 12 4 1 8 0 2 1 0 0.608 0.898 1.000 17 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(3), BAD(3), CASP9(2), GH1(1), GHR(6), NFKB1(7), NFKBIA(1), PDPK1(2), PIK3R1(8), PPP2CA(3), RELA(3), YWHAH(3) 3903135 42 29 42 7 8 15 3 9 7 0 0.0257 0.899 1.000 18 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2), LIPT1(4) 502082 6 6 6 2 1 3 0 0 2 0 0.589 0.901 1.000 19 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(5), HLA-DRA(6) 781158 11 10 11 4 4 4 0 3 0 0 0.560 0.913 1.000 20 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(4) 692992 7 7 7 2 3 0 0 2 2 0 0.639 0.914 1.000 21 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(6), CD4(5), HLA-DRA(6), IL1B(2), IL4(1), IL5RA(4) 1755840 25 18 25 7 9 7 0 6 3 0 0.273 0.938 1.000 22 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(30), CDC25A(3), CDC25B(4), CDC25C(7), CHEK1(4), MYT1(14), WEE1(2), YWHAH(3) 4533076 67 43 65 13 20 15 3 18 9 2 0.0393 0.938 1.000 23 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(18), AKT1(3), ATM(30), BAX(1), CDKN1A(1), CPB2(6), CSNK1A1(3), CSNK1D(2), FHL2(2), HIC1(5), HIF1A(5), HSPA1A(1), IGFBP3(5), MAPK8(5), MDM2(3), NFKBIB(5), NQO1(2) 6542844 97 56 96 19 28 26 4 19 18 2 0.00339 0.942 1.000 24 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SRP19(7), SRP54(4), SRP68(2), SRP72(7), SRP9(1), SRPR(8) 2476389 31 24 31 5 11 10 1 7 2 0 0.0557 0.966 1.000 25 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(3), CDC25A(3), CDC25B(4), CDC25C(7), CSK(5), GRB2(4), PRKCA(3), PTPRA(7), SRC(2) 3030864 38 29 38 7 15 9 0 8 6 0 0.0314 0.968 1.000 26 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(4), ALDOB(3), ALDOC(3), TPI1(1) 1285594 11 11 11 3 3 3 1 4 0 0 0.410 0.969 1.000 27 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(3), GRB2(4), NTRK1(6), PIK3R1(8), PLCG1(16), PRKCA(3), SHC1(3), SOS1(6) 4392826 49 35 47 8 16 17 2 8 6 0 0.0116 0.971 1.000 28 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(6), SQLE(4) 1047437 10 8 10 3 4 2 1 2 1 0 0.468 0.976 1.000 29 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(3), CD3E(2), CD4(5), CD58(1), CD8A(4), CSF3(1), IL3(1), IL8(1), KITLG(2) 2030518 22 20 22 6 4 8 2 6 2 0 0.282 0.977 1.000 30 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(30), CDC25A(3), CDC25B(4), CDC25C(7), CDK2(3), CHEK1(4), MYT1(14), RB1(6), WEE1(2), YWHAH(3) 5522460 76 45 73 13 20 20 4 20 10 2 0.0135 0.978 1.000 31 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(4), NR3C1(5), PPARG(1), RXRA(3), TNF(1) 1901245 16 16 16 5 4 2 2 7 1 0 0.458 0.980 1.000 32 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(3), CCL2(1), CSF1(1), LDLR(7), LPL(4) 1749371 16 16 16 5 7 4 0 3 2 0 0.256 0.983 1.000 33 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(3), ACAT2(3), ACYP1(1), ACYP2(3), EHHADH(6), GCDH(5), HADHA(4), SDHB(4), SDS(2) 2563914 31 22 30 6 9 14 2 2 4 0 0.0327 0.983 1.000 34 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(1), GGT1(5), SHMT1(1), SHMT2(5) 1352041 12 12 12 8 4 0 0 3 5 0 0.900 0.986 1.000 35 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(5), CD8A(4), CSF1(1), CSF3(1), IL11(2), IL3(1), IL4(1), IL7(1), IL8(1) 1995040 17 15 17 4 5 5 1 5 1 0 0.262 0.987 1.000 36 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(3), CD3E(2), CD4(5) 1057796 10 10 10 4 1 5 1 3 0 0 0.685 0.989 1.000 37 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(5), PGLYRP2(2) 592724 7 6 7 3 3 3 0 1 0 0 0.670 0.991 1.000 38 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(2), FOS(1), FYN(8), JUN(3), MAPK14(1), THBS1(12) 2433210 29 22 29 7 8 10 1 7 3 0 0.154 0.991 1.000 39 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(9), AOC2(4), AOC3(4), CES1(8), ESD(1) 1981456 26 16 26 4 8 9 1 7 1 0 0.0444 0.992 1.000 40 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(3), SPCS1(1), SPCS3(2) 1010636 8 7 8 3 2 1 0 5 0 0 0.697 0.992 1.000 41 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(10), APOBEC1(3), APOBEC2(1), APOBEC3B(4), APOBEC3F(1), APOBEC3G(3), APOBEC4(1) 2406087 23 17 23 4 9 6 3 4 1 0 0.0934 0.993 1.000 42 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(35), CREBBP(27), EP300(19), MAP2K1(5), MAP3K7(8), MAPK3(1), SKIL(2), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11) 7865498 127 69 122 29 34 36 5 22 28 2 0.0270 0.993 1.000 43 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(1), FLT3(8), IGF1(4), IL11(2), IL1A(2), IL3(1), KITLG(2), TGFB1(3), TGFB2(6), TGFB3(5) 2718178 34 25 34 9 9 9 0 11 5 0 0.295 0.995 1.000 44 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(5), ERBB4(33), NRG2(6), NRG3(13), PRKCA(3), PSEN1(2) 2956158 62 44 60 17 18 18 6 15 5 0 0.140 0.995 1.000 45 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(3), CCNH(2), CDC25A(3), CDC25B(4), CDC25C(7), MNAT1(2), SHH(4), XPO1(5) 2837526 30 17 30 5 10 9 1 7 3 0 0.0503 0.996 1.000 46 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(6), HADHA(4), SDS(2) 1591038 13 10 12 4 4 4 1 1 3 0 0.380 0.996 1.000 47 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(5), PLCG1(16), PRKCA(3), PTK2B(10) 2214210 34 26 32 8 19 6 1 4 4 0 0.123 0.996 1.000 48 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(4), ACADS(3), ACAT1(3), HADHA(4) 1776080 16 13 15 4 6 5 0 2 3 0 0.184 0.997 1.000 49 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(7), NR0B2(2), NR1H3(4), NR1H4(4), RXRA(3) 1790084 23 20 23 7 13 2 0 5 3 0 0.264 0.997 1.000 50 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(3), CAT(4), GH1(1), GHR(6), IGF1(4), IGF1R(15), PIK3R1(8), SHC1(3), SOD2(1) 3644761 45 32 45 11 8 17 2 11 7 0 0.114 0.998 1.000 51 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(6), GGPS1(2), SQLE(4) 1403200 12 9 12 4 4 3 1 2 2 0 0.585 0.998 1.000 52 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(2), GBA(6), GBA3(1), GGT1(5), SHMT1(1), SHMT2(5) 1798976 20 18 20 9 8 2 1 4 5 0 0.654 0.999 1.000 53 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(4), CBS(5), CTH(2), MUT(3) 1603502 15 13 14 9 4 2 1 1 7 0 0.951 0.999 1.000 54 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(3), CCL2(1), CCR5(3), CXCR4(1), FOS(1), GNAQ(3), JUN(3), MAPK14(1), MAPK8(5), PLCG1(16), PRKCA(3), PTK2B(10), SYT1(3) 4533592 54 38 52 10 22 16 2 10 4 0 0.00907 0.999 1.000 55 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(5), CD80(1), HLA-DRA(6), IL10(2), IL4(1) 1307987 15 13 15 5 6 4 0 4 1 0 0.485 0.999 1.000 56 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(8), ACO2(5), FH(2), IDH1(1), IDH2(1), MDH1(3), SDHB(4), SUCLA2(4) 2927140 28 20 27 7 14 6 0 5 3 0 0.161 0.999 1.000 57 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(3), CREB1(3), GRB2(4), MAPK1(2), MAPK3(1), MAPK7(7), MEF2A(1), MEF2B(4), MEF2C(3), MEF2D(6), NTRK1(6), PIK3R1(8), PLCG1(16), RPS6KA1(6), SHC1(3) 5486126 73 44 70 15 25 25 4 10 9 0 0.00717 0.999 1.000 58 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), B4GALT7(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), XYLT1(8), XYLT2(7) 2111506 35 28 34 10 19 10 1 2 3 0 0.148 1.000 1.000 59 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), B4GALT7(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), XYLT1(8), XYLT2(7) 2111506 35 28 34 10 19 10 1 2 3 0 0.148 1.000 1.000 60 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(2), DFFA(4), DFFB(3), GZMB(2), HMGB2(2), TOP2A(4), TOP2B(8) 2937986 27 20 26 6 5 9 1 6 6 0 0.337 1.000 1.000 61 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(9), PARK2(11), SNCA(1), SNCAIP(12), UBE2F(3), UBE2G2(1), UBE2L3(1), UBE2L6(1) 2110831 39 31 39 13 12 12 1 8 6 0 0.342 1.000 1.000 62 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(2), GLS(8), GLUD1(3) 1810485 17 14 17 6 5 5 0 6 1 0 0.486 1.000 1.000 63 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(1), IL1B(2), MST1(3), MST1R(10), TNF(1) 2150079 18 17 18 4 8 4 0 4 2 0 0.200 1.000 1.000 64 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(5), CPS1(18), GLS(8), GLUD1(3), GOT1(2) 2563580 38 31 38 10 11 9 2 14 2 0 0.247 1.000 1.000 65 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(4), HADH(3), HADHA(4), HADHB(4), HSD17B4(4), MECR(4), PPT1(5), PPT2(3) 2782629 31 19 30 8 6 11 3 4 7 0 0.114 1.000 1.000 66 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(4), SNAP25(2), STX1A(2) 1071596 10 10 10 4 3 1 0 4 2 0 0.750 1.000 1.000 67 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(2), TAT(4) 864014 8 8 8 4 4 3 0 1 0 0 0.720 1.000 1.000 68 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(8), ELK1(3), FOS(1), GRB2(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), NGFR(4), PIK3R1(8), PLCG1(16), RAF1(7), SHC1(3), SOS1(6) 5551059 74 47 69 17 23 22 2 19 8 0 0.0381 1.000 1.000 69 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(8), FOS(1), GRB2(4), JAK2(10), JUN(3), MAP2K1(5), MAPK3(1), PIK3R1(8), PLCG1(16), PRKCA(3), RAF1(7), RASA1(11), SHC1(3), SOS1(6), STAT1(7), STAT3(7), STAT5A(4), STAT5B(6), THPO(4) 9128654 114 61 109 23 29 34 5 29 17 0 0.00541 1.000 1.000 70 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(7), AKT1(3), ANXA1(2), CALM1(1), CALM2(3), GNAS(20), GNGT1(3), NFKB1(7), NOS3(5), NPPA(1), NR3C1(5), PIK3R1(8), RELA(3), SYT1(3) 5146022 71 50 70 15 25 19 0 17 10 0 0.0433 1.000 1.000 71 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), CAMP(2), DAG1(8), GNAQ(3), ITPKA(1), ITPKB(7) 1982156 23 19 23 8 10 4 0 7 2 0 0.434 1.000 1.000 72 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), ESCO1(4), ESCO2(4), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1) 5433623 59 38 59 13 18 18 2 14 7 0 0.0444 1.000 1.000 73 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(7), PDXK(3), PDXP(1), PSAT1(3) 1587252 14 9 14 6 2 6 0 4 1 1 0.678 1.000 1.000 74 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(3), FOS(1), JUN(3), KEAP1(8), MAPK1(2), MAPK14(1), MAPK8(5), NFE2L2(1), PRKCA(3) 2896964 27 21 27 8 8 11 2 3 3 0 0.210 1.000 1.000 75 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(3), MAPK14(1), MAPK8(5), NFKB1(7), RELA(3), TNFRSF13B(3), TNFRSF13C(2), TNFRSF17(1), TNFSF13B(3), TRAF2(2), TRAF3(3), TRAF6(5) 4763828 38 29 38 8 10 12 1 8 7 0 0.106 1.000 1.000 76 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), MIOX(3), UGDH(5) 2792705 36 27 36 11 8 13 0 10 5 0 0.324 1.000 1.000 77 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(2), GOT1(2), GOT2(2), LDHA(3), LDHB(4), LDHC(1), MPST(2) 2244553 20 16 20 5 7 8 1 2 2 0 0.207 1.000 1.000 78 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3) 4348062 55 35 54 14 11 17 0 18 9 0 0.137 1.000 1.000 79 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(4), ACADS(3), ACADVL(1), ACSL1(2), ACSL3(6), ACSL4(2), CPT1A(7), CPT2(5), DCI(2), EHHADH(6), HADHA(4), SCP2(4), SLC25A20(2) 5524345 50 32 49 12 16 10 5 12 7 0 0.0748 1.000 1.000 80 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(3), CDC34(2), CDK2(3), CUL1(14), E2F1(2), RB1(6), SKP2(5), TFDP1(3) 2810669 45 32 43 14 11 21 2 9 2 0 0.189 1.000 1.000 81 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(4), GSR(4), GSS(3), IL8(1), NFKB1(7), NOX1(4), RELA(3), TNF(1), XDH(11) 3266058 38 28 36 10 7 14 2 12 3 0 0.169 1.000 1.000 82 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(2), IFNG(2), IL2RA(2), IL4(1), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TGFBR3(4), TOB1(1), TOB2(4) 3477389 46 37 46 13 10 14 6 10 6 0 0.291 1.000 1.000 83 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(3), CDC34(2), CDK2(3), CUL1(14), E2F1(2), RB1(6), TFDP1(3) 2167672 33 24 31 10 11 13 2 5 2 0 0.209 1.000 1.000 84 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(5), AASDH(5), AASS(6), KARS(5) 2288651 21 17 21 7 5 10 1 5 0 0 0.461 1.000 1.000 85 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(4), ACAT1(3), ACAT2(3), EHHADH(6), HADHA(4), HADHB(4), SDS(2) 2746241 26 16 25 7 6 13 1 2 4 0 0.166 1.000 1.000 86 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(5), GOT1(2), GOT2(2), TAT(4), TYR(6) 1545208 19 18 19 7 5 7 1 6 0 0 0.555 1.000 1.000 87 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(4), NR1I3(3), PTGS1(7), PTGS2(5) 1756774 23 18 23 8 8 8 1 3 3 0 0.410 1.000 1.000 88 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(3), MTMR1(4), MTMR2(3), MTMR6(5), PHPT1(2), THTPA(2), TPK1(4) 2111496 23 18 23 7 5 11 1 4 2 0 0.425 1.000 1.000 89 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(1), RB1(6), SP1(6), SP3(3) 2189978 16 14 15 5 2 9 0 3 2 0 0.445 1.000 1.000 90 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(6), IFNAR1(5), IFNAR2(6), IFNB1(2), MAPK8(5), NFKB1(7), RELA(3), TNFRSF11A(3), TNFSF11(1), TRAF6(5) 3635783 44 33 44 12 13 15 1 10 5 0 0.164 1.000 1.000 91 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(27), EP300(19), ESR1(7), MAPK1(2), MAPK3(1), PELP1(5), SRC(2) 4802100 63 42 62 16 25 17 2 10 9 0 0.0524 1.000 1.000 92 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDK2(3), CUL1(14), E2F1(2), RB1(6), RBX1(1), SKP2(5), TFDP1(3) 2826466 37 26 35 10 9 17 2 6 3 0 0.138 1.000 1.000 93 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(19), CPT1A(7), LEPR(13), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(3) 4760287 58 34 58 13 17 13 2 20 6 0 0.0959 1.000 1.000 94 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(3), BCAR1(4), GRB2(4), ILK(3), ITGB1(6), MAPK1(2), MAPK3(1), PDPK1(2), PIK3R1(8), PTK2(10), SHC1(3), SOS1(6) 5328035 52 34 51 10 13 16 4 9 10 0 0.0267 1.000 1.000 95 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(3), APAF1(5), ATM(30), BAD(3), BAX(1), BCL2(2), BID(2), CASP3(2), CASP6(1), CASP7(2), CASP9(2), EIF2S1(2), PRKCA(3), PTK2(10), PXN(3), STAT1(7), TLN1(14) 8727169 92 52 90 20 29 25 9 16 11 2 0.0118 1.000 1.000 96 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(3), CDKN1A(1), GNAQ(3), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), SP1(6), SP3(3), SYT1(3) 6870159 95 57 93 25 37 29 1 15 13 0 0.0199 1.000 1.000 97 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(8), ELK1(3), FOS(1), GRB2(4), IGF1(4), IGF1R(15), IRS1(15), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), PIK3R1(8), PTPN11(5), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SRF(1) 7419300 105 57 102 28 28 31 2 26 18 0 0.0585 1.000 1.000 98 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(5), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), ESCO1(4), ESCO2(4), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1) 8198671 94 50 93 18 25 31 3 24 11 0 0.00300 1.000 1.000 99 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(2), CHST12(4), CHST13(2), PAPSS1(4), PAPSS2(4), SULT1A1(2), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(2) 3016658 31 23 31 9 16 8 1 5 1 0 0.217 1.000 1.000 100 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(12), GABRA2(5), GABRA3(7), GABRA4(7), GABRA5(5), GABRA6(8), GPX1(4), PRKCE(8) 2583328 56 39 54 21 13 11 7 22 3 0 0.596 1.000 1.000 101 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(3), COASY(1), DPYD(12), DPYS(7), ENPP1(5), ENPP3(4), PANK1(4), PANK2(3), PANK3(1), PANK4(1), PPCS(2), UPB1(2) 4574881 45 31 43 13 8 11 3 16 7 0 0.229 1.000 1.000 102 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(21), C5(11), C6(10), C7(2), C8A(5), C9(6) 4139342 55 34 54 16 17 16 3 14 5 0 0.239 1.000 1.000 103 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(4), ACOX3(8), FADS2(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5) 3331593 45 35 44 13 19 7 3 15 1 0 0.244 1.000 1.000 104 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(8), ELK1(3), FOS(1), GRB2(4), INSR(12), IRS1(15), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), PIK3R1(8), PTPN11(5), RAF1(7), RASA1(11), SHC1(3), SLC2A4(4), SOS1(6), SRF(1) 7639402 102 55 99 27 29 31 2 19 21 0 0.0389 1.000 1.000 105 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 DNAJC3(3), EIF2S1(2), EIF2S2(3), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3) 2934948 22 15 22 6 6 8 0 6 2 0 0.374 1.000 1.000 106 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(3), CREM(3), FOS(1), JUN(3), MAPK3(1), OPRK1(6), POLR2A(15), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 4223145 54 38 52 16 18 21 2 9 4 0 0.0947 1.000 1.000 107 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(3), ACAT2(3), ACOT11(5), ACYP1(1), ACYP2(3), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), EHHADH(6), ESCO1(4), ESCO2(4), FN3K(2), GCDH(5), HADHA(4), ITGB1BP3(2), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1), YOD1(2) 8520651 95 50 94 20 27 37 4 16 11 0 0.00325 1.000 1.000 108 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(20), GNA12(1), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAR2A(2), PRKAR2B(7) 3309933 40 29 40 11 9 15 2 8 6 0 0.188 1.000 1.000 109 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(3), CDC25B(4), CDKN1A(1), CHEK1(4), NEK1(4), WEE1(2) 2266134 18 16 17 6 5 6 0 4 3 0 0.711 1.000 1.000 110 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(24), CR2(8), FCGR2B(3), HLA-DRA(6), ICAM1(1), ITGAL(11), ITGB2(5), PTPRC(15) 4996443 74 46 70 23 21 26 0 19 6 2 0.196 1.000 1.000 111 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(4), ATM(30), BRCA1(14), CDKN1A(1), CHEK1(4), CHEK2(7), JUN(3), MAPK8(5), MDM2(3), MRE11A(2), NFKB1(7), NFKBIA(1), RAD50(9), RAD51(1), RBBP8(6), RELA(3), TP73(2) 9518657 102 59 101 21 23 26 6 30 15 2 0.0218 1.000 1.000 112 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(3), BCAT2(5), COASY(1), DPYD(12), DPYS(7), ENPP1(5), ENPP3(4), ILVBL(3), PANK1(4), PANK2(3), PANK3(1), PANK4(1), PPCDC(1), PPCS(2), UPB1(2), VNN1(1) 5682071 55 35 53 15 15 13 3 17 7 0 0.130 1.000 1.000 113 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(4), ALAS1(2), ALAS2(9), CPOX(2), FECH(6), HMBS(2), PPOX(2), UROD(1), UROS(3) 2493490 31 26 31 9 8 8 2 10 3 0 0.388 1.000 1.000 114 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(4), CRK(1), CXCR4(1), GNAI1(1), GNAQ(3), GNGT1(3), MAP2K1(5), MAPK1(2), MAPK3(1), NFKB1(7), PIK3C2G(7), PIK3R1(8), PLCG1(16), PRKCA(3), PTK2(10), PTK2B(10), PXN(3), RAF1(7), RELA(3) 8331611 95 52 91 19 30 23 4 21 17 0 0.00474 1.000 1.000 115 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 HLA-A(7), IL18(1), ITGB1(6), KLRC1(3), KLRC2(2), KLRC3(4), KLRD1(4), LAT(2), MAP2K1(5), MAPK3(1), PAK1(5), PIK3R1(8), PTK2B(10), PTPN6(3), SYK(6), VAV1(6) 5316019 73 54 71 21 17 24 2 19 11 0 0.164 1.000 1.000 116 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(6), F13A1(10), F2(5), F2R(2), FGA(7), FGB(2), FGG(2), PLAT(4), PLAU(2), PLG(11), SERPINB2(6), SERPINE1(3) 4408870 60 40 59 19 19 12 5 18 6 0 0.237 1.000 1.000 117 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(3), GRB2(4), HBXIP(1), PTK2B(10), SHC1(3), SOS1(6), SRC(2) 2903718 29 21 29 9 9 8 0 9 3 0 0.418 1.000 1.000 118 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), FPGS(1), GGH(3), SPR(2) 2134215 29 23 28 12 19 3 0 5 2 0 0.411 1.000 1.000 119 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), B3GNT1(3), FUT1(2), FUT9(5), GCNT2(1), ST8SIA1(4) 2004983 16 15 16 7 6 3 0 7 0 0 0.656 1.000 1.000 120 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(5), BAK1(3), BAX(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), DIABLO(1) 4414896 42 30 41 10 13 11 1 13 4 0 0.208 1.000 1.000 121 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(4), CYB5R3(1), GCK(4), GFPT1(3), GNE(5), GNPDA1(3), GNPDA2(2), HEXA(2), HEXB(2), HK1(11), HK2(9), HK3(5), PGM3(10), RENBP(2), UAP1(3) 5564768 66 43 66 17 21 22 3 16 4 0 0.0581 1.000 1.000 122 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(6), NDUFS2(2), NDUFV1(2) 2273199 22 19 22 7 5 7 1 7 2 0 0.546 1.000 1.000 123 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS1(4), PAPSS2(4), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(2) 2009771 21 17 21 7 10 7 0 3 1 0 0.526 1.000 1.000 124 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(7), CYP2A6(6), CYP2A7(5), NAT1(1), NAT2(4), XDH(11) 2622443 38 30 38 12 10 15 1 12 0 0 0.259 1.000 1.000 125 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(4), ALAS1(2), ALAS2(9), CPO(3), FECH(6), GATA1(3), HBB(1), HMBS(2), UROD(1), UROS(3) 2579949 34 28 34 10 9 7 3 12 3 0 0.424 1.000 1.000 126 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(4), AP2M1(5), ARF1(4), BAD(3), BTK(2), EEA1(9), GRASP(1), GSK3A(2), GSK3B(4), LYN(4), PDPK1(2), PFKL(4), PFKM(3), PFKP(8), PLCG1(16), PRKCE(8), RAB5A(2), RPS6KB1(4), VAV2(11) 8194563 99 48 97 26 35 30 6 18 9 1 0.0276 1.000 1.000 127 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(3), BCL2(2), BCR(10), CRKL(1), FOS(1), GRB2(4), JAK2(10), JUN(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), MYC(3), PIK3R1(8), RAF1(7), SOS1(6), STAT1(7), STAT5A(4), STAT5B(6) 8504524 102 56 98 27 26 32 2 23 19 0 0.0489 1.000 1.000 128 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(5), ARHGAP5(11), ARHGDIB(1), CASP1(2), CASP10(5), CASP3(2), CASP8(8), CASP9(2), GZMB(2), JUN(3), PRF1(1) 4235643 42 33 41 13 9 9 4 13 6 1 0.468 1.000 1.000 129 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(2), GPI(5), HK1(11), PFKL(4), PGK1(4), PKLR(5), TPI1(1) 3037998 35 28 35 12 11 11 2 10 1 0 0.330 1.000 1.000 130 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(3), EIF2B5(6), EIF2S1(2), EIF2S2(3), EIF4E(2), EIF4EBP1(2), GSK3B(4), IGF1(4), IGF1R(15), INPPL1(14), PDPK1(2), PIK3R1(8), PPP2CA(3), RPS6(1), RPS6KB1(4) 5464798 73 44 71 19 22 20 2 15 14 0 0.157 1.000 1.000 131 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(13), HSD17B1(4), HSD17B2(2), HSD17B3(1), HSD17B4(4), HSD17B7(2), HSD3B1(1), HSD3B2(3) 2662456 33 29 33 12 6 10 2 11 4 0 0.413 1.000 1.000 132 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(1), JUN(3), MAP2K1(5), MAPK1(2), MAPK3(1), MYC(3), NFKB1(7), NFKBIA(1), PLCB1(13), PRKCA(3), RAF1(7), RELA(3), TNF(1) 5102124 52 36 49 16 16 13 1 18 4 0 0.252 1.000 1.000 133 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(6), NDUFA1(1), SDHA(6), SDHB(4), SDHC(1), UQCRC1(2) 2174679 22 18 22 9 9 6 2 3 2 0 0.556 1.000 1.000 134 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDPS(6), HMGCR(6), LSS(4), MVD(2), MVK(8), NQO1(2), NQO2(3), SC5DL(4), SQLE(4) 3613235 42 26 40 13 13 10 1 12 6 0 0.328 1.000 1.000 135 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPAT6(3), AGPS(1), CHPT1(3), ENPP2(5), ENPP6(5), PAFAH1B1(5), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(1), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLD1(13), PLD2(13), PPAP2A(1), PPAP2C(4) 7613397 97 45 97 19 31 33 4 19 10 0 0.00147 1.000 1.000 136 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(10), EIF2AK4(7), EIF2B5(6), EIF2S1(2), EIF2S2(3), EIF5(5), GSK3B(4), PPP1CA(2) 3790495 39 30 39 11 8 13 1 13 4 0 0.317 1.000 1.000 137 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15(3), ALOX15B(3), ALOX5(6), ALOX5AP(3), DPEP1(1), GGT1(5), LTA4H(4), PLA2G2A(1), PLA2G6(5), PTGDS(1), PTGIS(5), PTGS1(7), PTGS2(5), TBXAS1(2) 4926750 54 39 54 15 20 12 4 11 7 0 0.0984 1.000 1.000 138 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(3), NFKB1(7), NFKBIA(1), PLCB1(13), PRKCA(3), RELA(3) 2704713 30 23 29 10 9 7 0 9 5 0 0.483 1.000 1.000 139 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(3), ACAT2(3), BDH1(4), HMGCS1(1), HMGCS2(3), OXCT1(6), OXCT2(1) 2364535 21 18 21 9 5 8 1 6 1 0 0.721 1.000 1.000 140 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(2), BRAF(9), CAMP(2), CREB1(3), CREB3(4), CREB5(4), MAPK1(2), RAF1(7), SNX13(6), SRC(2), TERF2IP(4) 3679905 47 33 45 14 15 12 0 13 7 0 0.321 1.000 1.000 141 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD3E(2), CD80(1), CD86(2), CTLA4(3), GRB2(4), HLA-DRA(6), ICOS(1), ITK(5), LCK(3), PIK3R1(8), PTPN11(5) 3488891 40 35 40 12 11 13 2 9 5 0 0.311 1.000 1.000 142 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(19), ACACB(22), FASN(14), MCAT(2), OXSM(3) 5146327 60 36 59 17 17 15 2 17 9 0 0.156 1.000 1.000 143 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(1), EPOR(2), GRIN1(4), HIF1A(5), JAK2(10), NFKB1(7), NFKBIA(1), RELA(3), SOD2(1) 4148563 35 23 35 11 6 12 1 8 8 0 0.421 1.000 1.000 144 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(18), ABCB11(8), ABCB4(17), ABCC1(9), ABCC3(8) 4713923 60 40 60 19 16 19 3 12 10 0 0.196 1.000 1.000 145 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(7), MBTPS1(8), MBTPS2(3), SCAP(9), SREBF1(8), SREBF2(6) 3866039 42 29 42 13 16 14 2 8 2 0 0.171 1.000 1.000 146 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG5(1), ATG7(4), BECN1(6), GABARAPL1(4), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNG(2), PIK3C3(10), PIK3R4(10), PRKAA1(4), PRKAA2(5), ULK1(12), ULK2(5) 6919459 89 48 87 25 18 22 8 29 12 0 0.176 1.000 1.000 147 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(1), PSMA3(2), PSMA4(4), PSMA6(4), PSMA7(4), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(1), PSMB8(3), PSMB9(1) 2874614 33 22 32 11 12 11 2 5 3 0 0.361 1.000 1.000 148 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(6), DHCR7(3), FDPS(6), HMGCR(6), HMGCS1(1), LSS(4), MVD(2), MVK(8), NSDHL(3), SC4MOL(4), SC5DL(4), SQLE(4) 4313277 51 31 49 16 14 11 2 16 8 0 0.396 1.000 1.000 149 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(5), CDO1(1), CTH(2), GOT1(2), GOT2(2), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), MPST(2), SDS(2), SULT1B1(3), SULT1C2(1), SULT1C4(2), SULT4A1(1) 4110623 39 27 39 12 15 14 1 6 3 0 0.214 1.000 1.000 150 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(3), BAD(3), CASP9(2), CDC42(1), ELK1(3), MAP2K1(5), MAPK3(1), NFKB1(7), PIK3R1(8), RAF1(7), RALBP1(5), RALGDS(10), RELA(3) 5404530 58 38 55 17 19 19 2 10 8 0 0.148 1.000 1.000 151 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(8), ELK1(3), EPOR(2), FOS(1), GRB2(4), JAK2(10), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(5), PLCG1(16), PTPN6(3), RAF1(7), SHC1(3), SOS1(6), STAT5A(4), STAT5B(6) 7054795 87 47 83 23 25 30 2 23 7 0 0.0800 1.000 1.000 152 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(13), AP2A1(4), AP2M1(5), BIN1(2), CALM1(1), CALM2(3), DNM1(5), EPN1(1), PICALM(2), PPP3CA(5), PPP3CB(6), PPP3CC(3), SYNJ1(7), SYNJ2(9), SYT1(3) 7108672 69 46 68 19 21 15 3 21 9 0 0.118 1.000 1.000 153 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(5), BAD(3), BAK1(3), BAX(1), BCL10(1), BCL2(2), BCL2L11(1), BID(2), CASP8AP2(7), CASP9(2), CES1(8) 3588047 35 20 35 12 13 12 1 7 2 0 0.398 1.000 1.000 154 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(3), B3GAT2(2), B3GAT3(3), B4GALT7(2), CHPF(2), CHST11(2), CHST12(4), CHST13(2), CHST14(2), CHST3(3), CHST7(7), CHSY1(4), DSE(5), UST(7), XYLT1(8), XYLT2(7) 4526816 63 39 63 18 33 19 1 8 2 0 0.0633 1.000 1.000 155 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1L(1), BNIP1(4), GOSR1(2), GOSR2(1), SEC22B(1), SNAP25(2), SNAP29(1), STX10(3), STX11(5), STX12(1), STX16(5), STX17(1), STX18(1), STX19(3), STX2(2), STX3(2), STX4(1), STX5(3), STX6(5), STX7(2), STX8(3), TSNARE1(6), USE1(4), VAMP4(1), VAMP5(1), VAMP7(4), VTI1A(1), VTI1B(3), YKT6(1) 5487041 70 38 69 19 27 19 2 13 9 0 0.143 1.000 1.000 156 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(1), DAB1(8), FYN(8), LRP8(3), RELN(37), VLDLR(5) 4608160 64 38 64 22 17 26 2 12 7 0 0.224 1.000 1.000 157 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(4), EPX(6), LPO(7), MPO(6), MTHFR(6), PRDX6(1), SHMT1(1), SHMT2(5), TPO(15) 3800101 54 40 54 17 21 10 3 12 8 0 0.315 1.000 1.000 158 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(6), DCXR(1), GUSB(8), RPE(4), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3) 5742609 52 31 52 15 15 19 1 11 6 0 0.139 1.000 1.000 159 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(9), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AMD1(3), AOC2(4), AOC3(4), ARG1(2), ASL(5), ASS1(7), CPS1(18), GATM(3), MAOA(1), MAOB(3), NAGS(1), ODC1(3), OTC(2), SAT1(1), SMS(3), SRM(1) 9671378 108 49 108 26 30 38 5 27 8 0 0.0116 1.000 1.000 160 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(27), DAXX(9), PAX3(7), PML(7), RARA(2), RB1(6), SIRT1(4), SP100(10), TNF(1), TNFRSF1A(3), TNFRSF1B(2) 5957742 78 51 77 24 29 22 2 15 10 0 0.145 1.000 1.000 161 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(3), ENO3(4), FARS2(6), GOT1(2), GOT2(2), PAH(4), TAT(4), YARS(3) 2730565 30 23 30 10 11 10 0 7 2 0 0.413 1.000 1.000 162 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(27), EP300(19), LPL(4), NCOA1(12), NCOA2(21), PPARG(1), RXRA(3) 6067007 87 45 86 28 26 28 4 18 11 0 0.214 1.000 1.000 163 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(11), KHK(2), LCT(15), MPI(3), PGM1(2), PYGL(6), PYGM(9), TPI1(1), TREH(3) 4393626 52 38 52 17 23 17 1 6 5 0 0.228 1.000 1.000 164 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(5), CSF1(1), CSF3(1), HLA-DRA(6), IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL11(2), IL12A(2), IL12B(1), IL13(1), IL1A(2), IL3(1), IL4(1), IL7(1), IL8(1), LTA(3), PDGFA(2), TGFB1(3), TGFB2(6), TGFB3(5), TNF(1) 4366098 52 38 52 18 15 16 2 15 4 0 0.411 1.000 1.000 165 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(3), PIK3R1(8), PLCB1(13), PLCG1(16), PRKCA(3), VAV1(6) 3497174 49 35 46 15 17 15 1 7 9 0 0.289 1.000 1.000 166 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(3), CREB1(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K6(1), MAP3K1(9), MAPK1(2), MAPK14(1), MAPK3(1), NFKB1(7), PIK3R1(8), RB1(6), RELA(3), SP1(6) 5650593 64 43 60 18 12 25 2 12 13 0 0.145 1.000 1.000 167 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(8), ACO2(5), ACSS1(9), ACSS2(6), FH(2), IDH1(1), IDH2(1), MDH1(3), SUCLA2(4) 4373260 43 29 42 14 19 8 3 7 6 0 0.241 1.000 1.000 168 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(1), PSMA3(2), PSMA4(4), PSMA6(4), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(1), PSMC2(5), PSMC3(6), PSMD1(2), PSMD11(2), PSMD12(2), PSMD13(2), PSMD2(12), PSMD6(1) 5259356 60 33 59 16 21 20 2 13 4 0 0.141 1.000 1.000 169 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(3), BAX(1), BCL2(2), CASP8(8), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8(5), NFKB1(7), NSMAF(7), RAF1(7), RELA(3), RIPK1(1), SMPD1(5), TNFRSF1A(3), TRADD(2), TRAF2(2) 6723990 80 47 76 25 30 19 2 15 14 0 0.192 1.000 1.000 170 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(3), CCND1(1), CCNE1(3), CDK2(3), CDK6(4), CDKN1A(1), E2F1(2), MAPK1(2), MAPK3(1), NFKB1(7), NFKBIA(1), PAK1(5), PIK3R1(8), RAF1(7), RB1(6), RELA(3), TFDP1(3) 5919420 60 38 58 17 13 22 2 14 9 0 0.200 1.000 1.000 171 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(4), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(7), METTL6(2), PCYT1A(6), PCYT1B(5), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), WBSCR22(4) 4619591 49 33 48 16 14 18 1 10 6 0 0.275 1.000 1.000 172 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(3), BAD(3), GRB2(4), IGF1R(15), IRS1(15), MAP2K1(5), MAPK1(2), MAPK3(1), PIK3R1(8), RAF1(7), SHC1(3), SOS1(6), YWHAH(3) 5513018 75 44 73 23 22 26 1 15 11 0 0.199 1.000 1.000 173 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(9), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), DDC(5), EPX(6), GOT1(2), GOT2(2), HPD(1), LPO(7), MAOA(1), MAOB(3), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), TAT(4), TPO(15) 7199899 93 52 93 28 31 24 4 28 6 0 0.132 1.000 1.000 174 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(5), IFNB1(2), JAK1(6), PTPRU(16), REG1A(3), STAT1(7), STAT2(4), TYK2(4) 4095015 47 32 47 15 17 15 2 10 3 0 0.262 1.000 1.000 175 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(5), IFNAR2(6), IFNB1(2), JAK1(6), STAT1(7), STAT2(4), TYK2(4) 3549994 35 23 35 12 10 11 2 9 3 0 0.388 1.000 1.000 176 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(5), CYSLTR2(1), GPR109B(3), GPR161(3), GPR171(2), GPR18(2), GPR39(6), GPR45(9), GPR65(1), GPR68(2), GPR75(4), GPR81(3) 3234234 41 32 41 16 20 8 3 8 2 0 0.379 1.000 1.000 177 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(3), EIF4A1(3), EIF4A2(4), EIF4E(2), EIF4EBP1(2), EIF4G1(19), EIF4G2(5), EIF4G3(7), GHR(6), IRS1(15), MAPK1(2), MAPK14(1), MAPK3(1), MKNK1(3), PABPC1(2), PDPK1(2), PIK3R1(8), PRKCA(3), RPS6KB1(4) 8256109 92 52 92 23 25 30 4 17 16 0 0.0643 1.000 1.000 178 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(13), CALM1(1), CALM2(3), CAPN2(3), CAPNS1(2), CAPNS2(2), EP300(19), HDAC1(3), HDAC2(2), MEF2D(6), NFATC1(11), NFATC2(14), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), SYT1(3) 8008371 99 48 98 28 41 24 0 19 15 0 0.0517 1.000 1.000 179 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(4), COPS5(2), CREB1(3), EDN1(2), EP300(19), HIF1A(5), JUN(3), LDHA(3), NOS3(5), P4HB(2) 5565792 49 32 48 15 16 13 3 10 7 0 0.236 1.000 1.000 180 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(11), HK2(9), HK3(5), IMPA1(3), PGM1(2), PGM3(10), TGDS(3) 3361435 47 33 47 17 14 18 2 10 3 0 0.320 1.000 1.000 181 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(5), ATM(30), BAX(1), BCL2(2), CCND1(1), CCNE1(3), CDK2(3), CDKN1A(1), E2F1(2), MDM2(3), PCNA(2), RB1(6), TIMP3(3) 5688841 62 38 60 18 16 19 3 16 6 2 0.281 1.000 1.000 182 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), HDAC5(6), MEF2A(1), MEF2B(4), MEF2C(3), MEF2D(6), PPARA(3), PPP3CA(5), PPP3CB(6), PPP3CC(3), SLC2A4(4), SYT1(3), YWHAH(3) 6619327 74 49 73 23 25 19 3 16 11 0 0.192 1.000 1.000 183 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), ABP1(9), AOC2(4), AOC3(4), CES1(8), CES7(7), DDHD1(9), ESCO1(4), ESCO2(4), LIPA(1), MYST3(20), MYST4(15), NAT6(2), PLA1A(2), PNPLA3(1), PRDX6(1), SH3GLB1(1) 8314382 95 47 94 27 27 30 3 26 9 0 0.118 1.000 1.000 184 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(5), BIRC2(3), BIRC3(3), CASP10(5), CASP3(2), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), GZMB(2), PRF1(1), SCAP(9), SREBF1(8), SREBF2(6) 5939073 63 43 62 18 20 14 4 19 6 0 0.253 1.000 1.000 185 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLRMT(10) 4398776 46 28 45 14 19 16 0 9 2 0 0.193 1.000 1.000 186 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(5), JAK1(6), JAK2(10), PLA2G2A(1), PTPRU(16), REG1A(3), STAT1(7) 3765039 51 31 51 17 14 18 3 11 5 0 0.351 1.000 1.000 187 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(3), C1S(5), C2(2), C3(21), C5(11), C6(10), C7(2), C8A(5), C8B(12), C9(6), MASP1(3) 6841557 81 46 78 24 25 19 4 21 11 1 0.283 1.000 1.000 188 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(2), CALM1(1), CALM2(3), ELK1(3), FCER1A(2), FOS(1), GRB2(4), JUN(3), LYN(4), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8(5), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), PAK2(6), PIK3R1(8), PLA2G4A(4), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), RAF1(7), SHC1(3), SOS1(6), SYK(6), SYT1(3), VAV1(6) 13182950 173 77 167 40 60 49 4 32 28 0 0.00109 1.000 1.000 189 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(30), ATR(13), CDC25C(7), CHEK1(4), CHEK2(7), YWHAH(3) 4991874 64 44 63 14 17 13 3 18 11 2 0.231 1.000 1.000 190 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 24 APC(35), ASAH1(2), CAMP(2), CASP3(2), CERK(5), CREB1(3), CREB3(4), CREB5(4), CXCL2(2), DAG1(8), EPHB2(8), FOS(1), GNAQ(3), ITPKA(1), ITPKB(7), JUN(3), MAP2K4(7), MAPK1(2), MAPK10(5), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4) 9111327 128 66 125 33 38 33 3 26 26 2 0.0236 1.000 1.000 191 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(27), DFFA(4), DFFB(3), GZMA(1), GZMB(2), HMGB2(2), PRF1(1), SET(3) 3465016 45 33 45 17 14 15 2 8 6 0 0.440 1.000 1.000 192 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(9), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), AOC2(4), AOC3(4), ASPA(1), CNDP1(1), DDC(5), HAL(1), HARS(5), HDC(7), HNMT(2), MAOA(1), MAOB(3), PRPS1(2), PRPS2(2) 8019771 93 46 93 29 30 25 4 25 9 0 0.196 1.000 1.000 193 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), IFNG(2), IKBKB(7), IL4(1), JUN(3), MAP3K1(9), MAP3K5(4), MAP4K5(3), MAPK14(1), MAPK8(5), NFKB1(7), NFKBIA(1), RELA(3), TNFRSF9(6), TRAF2(2) 6356161 55 33 52 16 21 9 3 10 12 0 0.268 1.000 1.000 194 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(8), ELK1(3), FOS(1), GRB2(4), IL2RA(2), IL2RB(2), IL2RG(5), JAK1(6), JAK3(9), JUN(3), LCK(3), MAP2K1(5), MAPK3(1), MAPK8(5), RAF1(7), SHC1(3), SOS1(6), STAT5A(4), STAT5B(6), SYK(6) 7641287 89 48 85 26 22 31 1 28 7 0 0.159 1.000 1.000 195 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL13(1), IL4(1), JUNB(1), MAF(3), MAP2K3(7), MAPK14(1), NFATC1(11), NFATC2(14), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 3958058 69 46 69 29 31 20 2 11 5 0 0.277 1.000 1.000 196 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTB(7), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), AKT1(3), AKT2(6), AKT3(6), ARHGAP5(11), BAD(3), BCAR1(4), BCL2(2), BIRC2(3), BIRC3(3), BRAF(9), CAPN2(3), CAV1(4), CAV2(2), CAV3(2), CCND1(1), CCND2(3), CCND3(2), CDC42(1), CHAD(2), COL11A1(19), COL11A2(7), COL1A1(6), COL1A2(23), COL2A1(13), COL3A1(7), COL4A1(18), COL4A2(10), COL4A4(10), COL4A6(6), COL5A1(21), COL5A2(11), COL5A3(10), COL6A1(7), COL6A2(15), COL6A3(36), COL6A6(27), COMP(2), CRK(1), CRKL(1), DIAPH1(7), DOCK1(15), EGF(8), EGFR(11), ELK1(3), ERBB2(12), FARP2(3), FLNA(16), FLNB(11), FLNC(22), FLT1(13), FN1(23), FYN(8), GRB2(4), GRLF1(15), GSK3B(4), HGF(13), IBSP(2), IGF1(4), IGF1R(15), ILK(3), ITGA1(7), ITGA10(6), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAV(5), ITGB1(6), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), JUN(3), KDR(8), LAMA1(36), LAMA2(23), LAMA3(17), LAMA4(14), LAMA5(23), LAMB1(11), LAMB2(16), LAMB3(14), LAMB4(13), LAMC1(11), LAMC2(7), LAMC3(13), MAP2K1(5), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(4), MET(7), MYL2(6), MYL7(1), MYL9(2), MYLK(15), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PARVA(1), PARVB(4), PARVG(3), PDGFA(2), PDGFB(5), PDGFC(5), PDGFD(5), PDGFRA(11), PDGFRB(10), PDPK1(2), PGF(1), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIP5K1C(8), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R12A(2), PRKCA(3), PRKCG(13), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(7), RAP1A(2), RAP1B(5), RAPGEF1(9), RELN(37), ROCK1(9), ROCK2(7), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SOS1(6), SOS2(11), SPP1(3), SRC(2), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TLN1(14), TLN2(21), TNC(17), TNN(17), TNR(18), TNXB(38), VASP(2), VAV1(6), VAV2(11), VAV3(10), VCL(1), VEGFC(8), VTN(4), VWF(19), ZYX(5) 120175487 1490 186 1464 624 532 400 54 345 156 3 0.754 1.000 1.000 197 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY7(13), ADCY8(21), ADCY9(8), ADORA2A(1), ADORA2B(1), ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRB1(7), ADRB2(7), AGTR1(1), ATP2A1(4), ATP2A2(5), ATP2A3(5), ATP2B1(10), ATP2B2(17), ATP2B3(18), ATP2B4(2), AVPR1A(8), AVPR1B(2), BDKRB1(1), BDKRB2(3), BST1(2), CACNA1A(16), CACNA1B(22), CACNA1C(27), CACNA1D(21), CACNA1E(30), CACNA1F(9), CACNA1G(15), CACNA1H(16), CACNA1I(16), CACNA1S(12), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CCKAR(4), CCKBR(6), CD38(3), CHRM1(2), CHRM2(13), CHRM3(9), CHRM5(1), CHRNA7(2), CYSLTR1(5), CYSLTR2(1), DRD1(3), EDNRA(3), EGFR(11), ERBB2(12), ERBB3(29), ERBB4(33), F2R(2), GNA11(5), GNA14(3), GNA15(3), GNAL(2), GNAQ(3), GNAS(20), GRIN1(4), GRIN2A(11), GRIN2C(4), GRIN2D(4), GRM1(26), GRM5(23), GRPR(7), HRH1(4), HRH2(8), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(21), ITPR3(31), LHCGR(10), LTB4R2(2), MYLK(15), MYLK2(2), NOS1(22), NOS3(5), NTSR1(5), OXTR(5), P2RX2(6), P2RX3(4), P2RX4(5), P2RX5(4), P2RX7(1), PDE1A(6), PDE1B(3), PDE1C(5), PDGFRA(11), PDGFRB(10), PHKA1(7), PHKA2(9), PHKB(1), PHKG1(2), PHKG2(7), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCD3(8), PLCD4(2), PLCE1(11), PLCG1(16), PLCG2(11), PLCZ1(3), PPID(3), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), PTAFR(5), PTGER3(3), PTGFR(3), PTK2B(10), RYR1(43), RYR2(61), RYR3(47), SLC25A4(2), SLC25A5(2), SLC25A6(5), SLC8A1(12), SLC8A2(9), SLC8A3(8), SPHK1(4), SPHK2(2), TACR1(3), TACR2(1), TACR3(11), TBXA2R(8), TNNC1(3), TRHR(4), TRPC1(5), VDAC1(2), VDAC2(2), VDAC3(2) 87935726 1324 183 1293 517 537 343 54 280 109 1 0.115 1.000 1.000 198 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 234 ADCYAP1R1(4), ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), ADRA1A(12), ADRA1B(4), ADRA2A(5), ADRA2B(4), ADRA2C(4), ADRB1(7), ADRB2(7), AGTR1(1), AGTR2(2), AVPR1A(8), AVPR1B(2), AVPR2(4), BDKRB1(1), BDKRB2(3), BRS3(3), C3AR1(5), C5AR1(5), CALCR(6), CALCRL(6), CCKAR(4), CCKBR(6), CGA(1), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), CNR1(7), CRHR1(10), CRHR2(3), CTSG(3), CYSLTR1(5), CYSLTR2(1), DRD1(3), DRD2(7), DRD3(7), DRD4(2), DRD5(11), EDNRA(3), F2(5), F2R(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(4), FSHB(1), GABBR1(8), GABBR2(8), GABRA1(12), GABRA2(5), GABRA3(7), GABRA4(7), GABRA5(5), GABRA6(8), GABRB1(5), GABRB2(2), GABRB3(7), GABRE(5), GABRG1(2), GABRG2(9), GABRG3(5), GABRP(4), GABRQ(9), GABRR1(6), GABRR2(4), GALR1(5), GALR2(9), GALR3(1), GH1(1), GH2(3), GHR(6), GHRHR(4), GHSR(8), GIPR(3), GLP1R(1), GLP2R(8), GLRA1(4), GLRA2(3), GLRA3(4), GLRB(8), GNRHR(4), GPR156(3), GPR35(3), GPR50(7), GPR63(1), GPR83(4), GRIA1(17), GRIA2(17), GRIA3(6), GRIA4(7), GRID1(16), GRID2(14), GRIK1(8), GRIK2(11), GRIK3(12), GRIK4(9), GRIK5(10), GRIN1(4), GRIN2A(11), GRIN2B(18), GRIN2C(4), GRIN2D(4), GRIN3A(14), GRIN3B(2), GRM1(26), GRM2(19), GRM3(12), GRM4(6), GRM5(23), GRM6(8), GRM7(15), GRM8(15), GRPR(7), GZMA(1), HCRTR1(3), HCRTR2(3), HRH1(4), HRH2(8), HRH3(3), HRH4(3), HTR1A(10), HTR1B(8), HTR1D(3), HTR1E(5), HTR1F(5), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8), LEPR(13), LHCGR(10), LTB4R(1), LTB4R2(2), MAS1(1), MC2R(2), MC3R(3), MC4R(5), MC5R(5), MCHR1(5), MCHR2(4), MLNR(2), MTNR1A(4), MTNR1B(6), NMBR(3), NMUR1(3), NMUR2(3), NPBWR1(10), NPBWR2(6), NPFFR1(1), NPFFR2(8), NPY1R(3), NPY2R(3), NPY5R(3), NR3C1(5), NTSR1(5), NTSR2(3), OPRD1(1), OPRK1(6), OPRL1(6), OPRM1(3), OXTR(5), P2RX2(6), P2RX3(4), P2RX4(5), P2RX5(4), P2RX7(1), P2RY1(3), P2RY10(10), P2RY13(2), P2RY14(4), P2RY2(5), P2RY4(2), P2RY6(6), P2RY8(6), PARD3(9), PPYR1(6), PRL(1), PRLHR(4), PRLR(2), PRSS1(2), PRSS3(3), PTAFR(5), PTGDR(6), PTGER2(4), PTGER3(3), PTGER4(4), PTGFR(3), PTH2R(5), RXFP1(6), RXFP2(6), SCTR(2), SSTR1(9), SSTR2(3), SSTR3(5), SSTR4(11), SSTR5(4), TAAR1(2), TAAR2(3), TAAR5(5), TAAR6(6), TAAR9(1), TACR1(3), TACR2(1), TACR3(11), TBXA2R(8), THRA(4), THRB(7), TRHR(4), TRPV1(6), TSHB(2), TSHR(8), UTS2R(1), VIPR1(2), VIPR2(3) 71890428 1212 175 1192 462 459 312 54 313 73 1 0.0285 1.000 1.000 199 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 200 ABI2(3), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), APC(35), APC2(12), ARAF(8), ARHGEF1(9), ARHGEF12(8), ARHGEF4(5), ARHGEF6(12), ARHGEF7(7), ARPC1A(3), ARPC2(1), ARPC4(2), BAIAP2(4), BCAR1(4), BDKRB1(1), BDKRB2(3), BRAF(9), CD14(2), CDC42(1), CFL1(1), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), CRK(1), CRKL(1), CSK(5), CYFIP1(11), CYFIP2(13), DIAPH1(7), DIAPH2(6), DIAPH3(9), DOCK1(15), EGF(8), EGFR(11), EZR(3), F2(5), F2R(2), FGD1(10), FGD3(10), FGF1(2), FGF10(5), FGF11(1), FGF12(5), FGF13(7), FGF14(6), FGF17(4), FGF18(2), FGF2(2), FGF20(3), FGF21(2), FGF22(1), FGF23(1), FGF3(1), FGF5(1), FGF6(5), FGF7(2), FGF8(1), FGF9(6), FGFR1(11), FGFR2(8), FGFR3(3), FGFR4(6), FN1(23), GIT1(3), GNA12(1), GNA13(3), GNG12(1), GRLF1(15), GSN(9), IQGAP1(11), IQGAP2(8), IQGAP3(12), ITGA1(7), ITGA10(6), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAD(9), ITGAE(6), ITGAL(11), ITGAM(6), ITGAV(5), ITGAX(8), ITGB1(6), ITGB2(5), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), LIMK1(3), LIMK2(1), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MOS(9), MSN(9), MYH10(24), MYH14(12), MYH9(23), MYL2(6), MYL7(1), MYL9(2), MYLK(15), MYLK2(2), NCKAP1(8), NCKAP1L(10), NRAS(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PDGFA(2), PDGFB(5), PDGFRA(11), PDGFRB(10), PFN2(2), PFN3(2), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1B(1), PIP5K1C(8), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R12A(2), PPP1R12B(12), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(7), RDX(4), ROCK1(9), ROCK2(7), RRAS(1), RRAS2(3), SCIN(5), SLC9A1(8), SOS1(6), SOS2(11), SSH1(7), SSH2(17), SSH3(6), TIAM1(28), TIAM2(20), TMSL3(1), VAV1(6), VAV2(11), VAV3(10), VCL(1), WAS(1), WASF1(3), WASF2(6), WASL(2) 89602926 1146 170 1127 448 422 298 40 250 132 4 0.487 1.000 1.000 200 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(7), CHAD(2), COL11A1(19), COL11A2(7), COL17A1(7), COL1A1(6), COL1A2(23), COL2A1(13), COL3A1(7), COL4A1(18), COL4A2(10), COL4A4(10), COL4A6(6), COL5A1(21), COL5A2(11), COL5A3(10), COL6A1(7), COL6A2(15), COL6A3(36), COL6A6(27), COMP(2), DES(1), DSC1(1), DSC2(9), DSC3(2), DSG1(4), DSG2(3), DSG3(9), DSG4(7), FN1(23), GJA1(9), GJA10(3), GJA3(1), GJA4(2), GJA5(3), GJA8(3), GJA9(3), GJB3(3), GJB4(2), GJB5(1), GJB6(5), GJB7(1), GJC1(1), GJC2(2), GJD2(3), GJD4(5), IBSP(2), INA(5), ITGA6(4), ITGB4(12), KRT1(4), KRT10(6), KRT12(3), KRT13(8), KRT14(2), KRT15(1), KRT16(7), KRT17(4), KRT18(2), KRT19(1), KRT2(8), KRT20(4), KRT23(8), KRT24(3), KRT25(6), KRT27(6), KRT28(8), KRT3(8), KRT31(5), KRT32(4), KRT33A(7), KRT33B(5), KRT34(5), KRT35(6), KRT36(5), KRT37(3), KRT38(3), KRT39(7), KRT4(4), KRT40(1), KRT5(2), KRT6A(10), KRT6B(3), KRT6C(8), KRT7(2), KRT71(2), KRT72(5), KRT73(10), KRT74(2), KRT75(2), KRT76(3), KRT77(2), KRT78(2), KRT79(3), KRT8(5), KRT81(3), KRT82(2), KRT83(3), KRT84(4), KRT85(2), KRT86(2), KRT9(1), LAMA1(36), LAMA2(23), LAMA3(17), LAMA4(14), LAMA5(23), LAMB1(11), LAMB2(16), LAMB3(14), LAMB4(13), LAMC1(11), LAMC2(7), LAMC3(13), LMNA(4), LMNB1(1), LMNB2(4), NES(5), PRPH(3), RELN(37), SPP1(3), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TNC(17), TNN(17), TNR(18), TNXB(38), VIM(8), VTN(4), VWF(19) 81726449 1026 168 1017 480 361 276 41 256 91 1 0.994 1.000 1.000 201 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRB1(7), ADRB2(7), ANXA6(2), ARRB1(3), ARRB2(1), ATP1A4(12), ATP1B1(1), ATP1B2(2), ATP1B3(3), ATP2A2(5), ATP2A3(5), ATP2B1(10), ATP2B2(17), ATP2B3(18), CACNA1A(16), CACNA1B(22), CACNA1C(27), CACNA1D(21), CACNA1E(30), CACNA1S(12), CACNB1(1), CACNB3(2), CALM1(1), CALM2(3), CALR(3), CAMK1(2), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CASQ1(6), CASQ2(2), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), GJA1(9), GJA4(2), GJA5(3), GJB3(3), GJB4(2), GJB5(1), GJB6(5), GNA11(5), GNAI2(2), GNAI3(6), GNAQ(3), GNAZ(11), GNB2(4), GNB4(3), GNG12(1), GNG13(2), GNG7(3), GNGT1(3), GRK6(2), ITPR1(21), ITPR2(21), ITPR3(31), KCNB1(8), KCNJ3(9), KCNJ5(3), MIB1(4), NME7(1), PKIA(1), PKIG(2), PLCB3(8), PRKACA(3), PRKACB(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCQ(7), PRKD1(16), RGS1(2), RGS10(3), RGS11(1), RGS14(2), RGS16(3), RGS17(2), RGS18(4), RGS19(2), RGS2(2), RGS20(4), RGS3(13), RGS4(3), RGS5(3), RGS6(14), RGS7(2), RGS9(8), RYR1(43), RYR2(61), RYR3(47), SLC8A1(12), SLC8A3(8), USP5(4), YWHAB(1), YWHAH(3), YWHAQ(2) 61531238 913 163 902 371 363 231 40 193 85 1 0.366 1.000 1.000 202 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(6), CD36(2), CD44(4), CHAD(2), COL11A1(19), COL11A2(7), COL1A1(6), COL1A2(23), COL2A1(13), COL3A1(7), COL4A1(18), COL4A2(10), COL4A4(10), COL4A6(6), COL5A1(21), COL5A2(11), COL5A3(10), COL6A1(7), COL6A2(15), COL6A3(36), COL6A6(27), DAG1(8), FN1(23), FNDC1(13), FNDC3A(6), FNDC4(2), FNDC5(1), GP5(5), GP6(3), GP9(1), HMMR(7), HSPG2(22), IBSP(2), ITGA1(7), ITGA10(6), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAV(5), ITGB1(6), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), LAMA1(36), LAMA2(23), LAMA3(17), LAMA4(14), LAMA5(23), LAMB1(11), LAMB2(16), LAMB3(14), LAMB4(13), LAMC1(11), LAMC2(7), LAMC3(13), RELN(37), SDC1(1), SDC2(2), SDC3(4), SDC4(3), SPP1(3), SV2A(10), SV2B(2), SV2C(6), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TNC(17), TNN(17), TNR(18), TNXB(38), VTN(4), VWF(19) 73529504 888 163 878 408 315 221 33 227 91 1 0.981 1.000 1.000 203 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 243 ACVR1B(12), ACVR1C(3), AKT1(3), AKT2(6), AKT3(6), ARRB1(3), ARRB2(1), ATF2(1), BDNF(5), BRAF(9), CACNA1A(16), CACNA1B(22), CACNA1C(27), CACNA1D(21), CACNA1E(30), CACNA1F(9), CACNA1G(15), CACNA1H(16), CACNA1I(16), CACNA1S(12), CACNA2D1(7), CACNA2D2(6), CACNA2D3(13), CACNA2D4(8), CACNB1(1), CACNB2(12), CACNB3(2), CACNB4(4), CACNG1(1), CACNG2(1), CACNG3(5), CACNG4(3), CACNG5(7), CACNG6(1), CACNG7(8), CACNG8(1), CASP3(2), CD14(2), CDC25B(4), CDC42(1), CRK(1), CRKL(1), DAXX(9), DDIT3(3), DUSP1(2), DUSP10(6), DUSP14(2), DUSP16(8), DUSP2(2), DUSP3(1), DUSP5(7), DUSP6(3), DUSP8(1), DUSP9(3), ECSIT(1), EGF(8), EGFR(11), ELK1(3), ELK4(1), FAS(3), FASLG(2), FGF1(2), FGF10(5), FGF11(1), FGF12(5), FGF13(7), FGF14(6), FGF17(4), FGF18(2), FGF2(2), FGF20(3), FGF21(2), FGF22(1), FGF23(1), FGF3(1), FGF5(1), FGF6(5), FGF7(2), FGF8(1), FGF9(6), FGFR1(11), FGFR2(8), FGFR3(3), FGFR4(6), FLNA(16), FLNB(11), FLNC(22), FOS(1), GNA12(1), GNG12(1), GRB2(4), IKBKB(7), IL1A(2), IL1B(2), IL1R1(4), IL1R2(5), JUN(3), JUND(1), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K5(1), MAP2K6(1), MAP3K1(9), MAP3K10(8), MAP3K12(9), MAP3K13(7), MAP3K14(3), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAP3K5(4), MAP3K6(5), MAP3K7(8), MAP4K1(3), MAP4K2(4), MAP4K3(3), MAP4K4(8), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(7), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MAPKAPK2(1), MAPKAPK3(4), MAPKAPK5(1), MAPT(4), MAX(3), MEF2C(3), MKNK1(3), MKNK2(1), MOS(9), MYC(3), NF1(18), NFATC2(14), NFATC4(13), NFKB1(7), NFKB2(2), NLK(6), NR4A1(4), NRAS(2), NTF3(3), NTRK1(6), NTRK2(9), PAK1(5), PAK2(6), PDGFA(2), PDGFB(5), PDGFRA(11), PDGFRB(10), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PPM1A(3), PPM1B(8), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PPP5C(6), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), PTPN5(1), PTPN7(3), PTPRR(7), RAC2(2), RAC3(3), RAF1(7), RAP1A(2), RAP1B(5), RAPGEF2(10), RASA1(11), RASA2(4), RASGRF1(7), RASGRF2(12), RASGRP1(5), RASGRP2(6), RASGRP3(4), RASGRP4(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA4(1), RPS6KA5(2), RRAS(1), RRAS2(3), SOS1(6), SOS2(11), SRF(1), STK3(4), STK4(3), STMN1(2), TAOK1(10), TAOK2(15), TAOK3(9), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TNF(1), TNFRSF1A(3), TRAF2(2), TRAF6(5), ZAK(7) 92408588 1196 162 1170 422 457 326 48 222 142 1 0.00394 1.000 1.000 204 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(4), ABLIM1(9), ABLIM2(3), ABLIM3(4), ARHGEF12(8), CDC42(1), CDK5(2), CFL1(1), CXCR4(1), DCC(22), DPYSL2(1), DPYSL5(6), EFNA1(2), EFNA2(1), EFNA4(1), EFNA5(2), EFNB1(2), EFNB2(3), EFNB3(4), EPHA1(10), EPHA2(9), EPHA3(15), EPHA4(14), EPHA5(22), EPHA6(22), EPHA7(4), EPHA8(11), EPHB1(18), EPHB2(8), EPHB3(11), EPHB4(8), EPHB6(8), FES(6), FYN(8), GNAI1(1), GNAI2(2), GNAI3(6), GSK3B(4), ITGB1(6), L1CAM(12), LIMK1(3), LIMK2(1), LRRC4C(2), MAPK1(2), MAPK3(1), MET(7), NCK1(6), NCK2(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), NGEF(6), NRAS(2), NRP1(13), NTN1(6), NTN4(2), NTNG1(14), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PLXNA1(24), PLXNA2(17), PLXNA3(11), PLXNB1(10), PLXNB2(12), PLXNB3(11), PLXNC1(14), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PTK2(10), RAC2(2), RAC3(3), RASA1(11), RGS3(13), RHOD(1), RND1(1), ROBO1(21), ROBO2(21), ROBO3(6), ROCK1(9), ROCK2(7), SEMA3A(14), SEMA3B(4), SEMA3C(6), SEMA3D(10), SEMA3E(9), SEMA3F(10), SEMA3G(5), SEMA4A(5), SEMA4B(5), SEMA4C(4), SEMA4D(11), SEMA4F(6), SEMA4G(1), SEMA5A(20), SEMA5B(13), SEMA6A(13), SEMA6B(3), SEMA6C(6), SEMA6D(15), SEMA7A(8), SLIT1(5), SLIT2(23), SLIT3(11), SRGAP1(11), SRGAP2(5), SRGAP3(8), UNC5A(8), UNC5B(6), UNC5C(12), UNC5D(12) 64275491 924 159 916 367 306 228 57 229 101 3 0.641 1.000 1.000 205 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 127 ACTB(7), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), AKT1(3), AKT2(6), AKT3(6), AMOTL1(5), ASH1L(28), CASK(2), CDC42(1), CGN(7), CLDN1(2), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(4), CLDN18(2), CLDN19(3), CLDN20(3), CLDN22(2), CLDN23(2), CLDN3(1), CLDN4(5), CLDN5(2), CLDN6(4), CLDN8(1), CLDN9(3), CSDA(4), CSNK2A1(8), CSNK2A2(4), CSNK2B(1), CTNNA1(11), CTNNA2(16), CTNNA3(9), CTTN(5), EPB41(7), EPB41L1(5), EPB41L2(8), EPB41L3(19), EXOC3(3), EXOC4(7), F11R(2), GNAI1(1), GNAI2(2), GNAI3(6), HCLS1(3), IGSF5(2), INADL(9), JAM2(2), JAM3(4), LLGL1(8), LLGL2(5), MAGI1(14), MAGI2(23), MAGI3(4), MLLT4(18), MPDZ(18), MPP5(1), MYH1(17), MYH10(24), MYH11(18), MYH13(20), MYH14(12), MYH15(10), MYH2(23), MYH3(23), MYH4(16), MYH6(24), MYH7(15), MYH7B(15), MYH8(13), MYH9(23), MYL2(6), MYL7(1), MYL9(2), NRAS(2), OCLN(4), PARD3(9), PARD6A(1), PARD6B(3), PARD6G(3), PPM1J(2), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), PPP2R3A(7), PPP2R3B(6), PPP2R4(3), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCI(4), PRKCQ(7), RAB13(2), RAB3B(3), RRAS(1), RRAS2(3), SPTAN1(18), SRC(2), SYMPK(5), TJAP1(2), TJP1(11), TJP2(8), TJP3(6), VAPA(1), YES1(2), ZAK(7) 62607172 829 155 819 294 298 220 31 204 75 1 0.0953 1.000 1.000 206 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 128 ALCAM(6), CADM1(11), CADM3(5), CD2(2), CD22(3), CD226(2), CD274(1), CD276(6), CD34(3), CD4(5), CD40(1), CD40LG(4), CD58(1), CD6(5), CD80(1), CD86(2), CD8A(4), CD8B(2), CD99(1), CDH15(4), CDH2(11), CDH3(8), CDH4(17), CDH5(5), CLDN1(2), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(4), CLDN18(2), CLDN19(3), CLDN20(3), CLDN22(2), CLDN23(2), CLDN3(1), CLDN4(5), CLDN5(2), CLDN6(4), CLDN8(1), CLDN9(3), CNTN1(15), CNTN2(7), CNTNAP1(15), CNTNAP2(29), CTLA4(3), ESAM(5), F11R(2), GLG1(13), HLA-A(7), HLA-C(3), HLA-DMA(1), HLA-DMB(3), HLA-DOA(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(6), HLA-E(3), HLA-F(7), HLA-G(3), ICAM1(1), ICAM2(2), ICAM3(1), ICOS(1), ITGA4(9), ITGA6(4), ITGA8(5), ITGA9(7), ITGAL(11), ITGAM(6), ITGAV(5), ITGB1(6), ITGB2(5), ITGB7(4), ITGB8(8), JAM2(2), JAM3(4), L1CAM(12), MADCAM1(1), MAG(9), MPZ(2), MPZL1(1), NCAM1(4), NCAM2(16), NEGR1(6), NEO1(10), NFASC(15), NLGN1(13), NLGN2(8), NLGN3(10), NRCAM(8), NRXN1(27), NRXN2(20), NRXN3(21), OCLN(4), PDCD1(2), PDCD1LG2(1), PTPRC(15), PTPRF(15), PTPRM(25), PVR(2), PVRL1(1), PVRL2(4), PVRL3(4), SDC1(1), SDC2(2), SDC3(4), SDC4(3), SELE(4), SELL(4), SELP(6), SELPLG(6), SIGLEC1(10), SPN(3), VCAM1(8), VCAN(36) 47628970 707 154 694 281 243 209 21 174 60 0 0.263 1.000 1.000 207 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(5), ACVR1B(12), ACVR2A(6), ACVR2B(3), AMHR2(2), BMP2(2), BMP7(5), BMPR1A(3), BMPR1B(4), BMPR2(11), CCL1(2), CCL11(1), CCL15(2), CCL16(1), CCL18(2), CCL19(1), CCL2(1), CCL20(1), CCL22(1), CCL23(1), CCL24(1), CCL25(1), CCL27(1), CCL5(1), CCL7(1), CCL8(2), CCR1(2), CCR2(5), CCR3(6), CCR5(3), CCR6(1), CCR7(2), CCR8(1), CCR9(3), CD27(2), CD40(1), CD40LG(4), CD70(1), CLCF1(2), CNTF(3), CNTFR(2), CSF1(1), CSF1R(7), CSF2RA(8), CSF2RB(7), CSF3(1), CSF3R(6), CX3CL1(6), CX3CR1(3), CXCL10(1), CXCL16(3), CXCL2(2), CXCL9(2), CXCR4(1), CXCR6(2), EDA(1), EDA2R(3), EDAR(5), EGF(8), EGFR(11), EPOR(2), FAS(3), FASLG(2), FLT1(13), FLT3(8), FLT4(17), GDF5(7), GH1(1), GH2(3), GHR(6), HGF(13), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IFNG(2), IFNGR1(5), IFNGR2(1), IFNK(1), IFNW1(2), IL10(2), IL10RA(4), IL10RB(2), IL11(2), IL11RA(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL13(1), IL13RA1(3), IL15RA(3), IL17B(3), IL17RA(6), IL17RB(1), IL18(1), IL18R1(2), IL18RAP(2), IL1A(2), IL1B(2), IL1R1(4), IL1R2(5), IL1RAP(5), IL20(1), IL20RA(6), IL21(2), IL21R(9), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL25(1), IL26(4), IL28A(2), IL28B(3), IL28RA(1), IL2RA(2), IL2RB(2), IL2RG(5), IL3(1), IL3RA(5), IL4(1), IL4R(1), IL5RA(4), IL6R(1), IL6ST(4), IL7(1), IL7R(6), IL8(1), IL9R(3), INHBA(7), INHBB(8), INHBC(3), INHBE(1), KDR(8), KIT(12), KITLG(2), LEPR(13), LIF(1), LIFR(10), LTA(3), LTBR(1), MET(7), NGFR(4), OSM(2), OSMR(4), PDGFB(5), PDGFC(5), PDGFRA(11), PDGFRB(10), PF4V1(1), PLEKHO2(1), PRL(1), PRLR(2), RELT(2), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(3), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(3), TNFRSF13C(2), TNFRSF17(1), TNFRSF19(7), TNFRSF1A(3), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(4), TNFRSF4(2), TNFRSF8(2), TNFRSF9(6), TNFSF10(3), TNFSF11(1), TNFSF13B(3), TNFSF14(2), TNFSF15(2), TNFSF18(2), TNFSF4(1), TNFSF8(3), TPO(15), TSLP(3), VEGFC(8), XCL1(1), XCR1(3) 58113564 705 148 689 285 219 205 33 172 74 2 0.511 1.000 1.000 208 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(2), ACTA2(6), ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ARRB1(3), ARRB2(1), ATF2(1), ATF5(2), ATP2A2(5), ATP2A3(5), CACNB3(2), CALCA(1), CALM1(1), CALM2(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CNN1(2), CNN2(1), CORIN(13), CREB3(4), CRHR1(10), DGKZ(4), ETS2(3), FOS(1), GABPA(2), GABPB2(2), GJA1(9), GNAQ(3), GNB2(4), GNB4(3), GNG12(1), GNG13(2), GNG7(3), GNGT1(3), GRK6(2), GUCA2A(1), GUCY1A3(14), IGFBP1(5), IGFBP2(2), IGFBP3(5), IGFBP4(1), IGFBP6(1), IL1B(2), ITPR1(21), ITPR2(21), ITPR3(31), JUN(3), MIB1(4), MYL2(6), MYLK2(2), NFKB1(7), NOS1(22), NOS3(5), OXT(1), OXTR(5), PDE4B(4), PDE4D(1), PKIA(1), PKIG(2), PLCB3(8), PLCD1(4), PLCG1(16), PLCG2(11), PRKACA(3), PRKACB(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCH(6), PRKCQ(7), PRKD1(16), RAMP3(3), RGS1(2), RGS10(3), RGS11(1), RGS14(2), RGS16(3), RGS17(2), RGS18(4), RGS19(2), RGS2(2), RGS20(4), RGS3(13), RGS4(3), RGS5(3), RGS6(14), RGS7(2), RGS9(8), RLN1(1), RYR1(43), RYR2(61), RYR3(47), SLC8A1(12), SP1(6), TNXB(38), USP5(4), YWHAB(1), YWHAH(3), YWHAQ(2) 56801553 779 148 770 316 303 188 32 182 73 1 0.456 1.000 1.000 209 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(2), ACTA2(6), ACTN2(22), ACTN3(2), ACTN4(6), DES(1), DMD(48), FAM48A(7), MYBPC1(5), MYBPC2(7), MYBPC3(4), MYH3(23), MYH6(24), MYH7(15), MYH8(13), MYL1(1), MYL2(6), MYL3(2), MYL9(2), MYOM1(6), NEB(48), TMOD1(2), TNNI1(1), TNNI2(4), TNNT1(3), TNNT2(2), TPM1(4), TPM3(3), TPM4(3), TTN(401), VIM(8) 44816195 681 148 669 221 178 188 40 232 38 5 0.0626 1.000 1.000 210 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 160 ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRA2A(5), ADRA2C(4), ADRB1(7), ADRB2(7), AGTR1(1), AGTR2(2), AVPR1A(8), AVPR1B(2), AVPR2(4), BDKRB1(1), BDKRB2(3), BRS3(3), C3AR1(5), CCBP2(2), CCKAR(4), CCKBR(6), CCR1(2), CCR10(2), CCR2(5), CCR3(6), CCR5(3), CCR6(1), CCR7(2), CCR8(1), CCR9(3), CCRL1(5), CHML(3), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), CMKLR1(2), CNR1(7), CX3CR1(3), CXCR4(1), DRD1(3), DRD2(7), DRD3(7), DRD4(2), DRD5(11), EDNRA(3), F2R(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(4), GALR1(5), GALR2(9), GALR3(1), GALT(1), GHSR(8), GNB2L1(4), GPR17(1), GPR173(3), GPR174(3), GPR27(5), GPR3(4), GPR35(3), GPR37(9), GPR37L1(4), GPR4(2), GPR50(7), GPR6(9), GPR63(1), GPR77(1), GPR83(4), GPR85(2), GPR87(4), GRPR(7), HCRTR1(3), HCRTR2(3), HRH1(4), HRH2(8), HRH3(3), HTR1A(10), HTR1B(8), HTR1D(3), HTR1E(5), HTR1F(5), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8), LHCGR(10), LTB4R(1), MAS1(1), MC3R(3), MC4R(5), MC5R(5), MLNR(2), MTNR1A(4), MTNR1B(6), NMBR(3), NMUR1(3), NMUR2(3), NPY1R(3), NPY2R(3), NPY5R(3), NTSR1(5), NTSR2(3), OPN1SW(1), OPN3(4), OPRD1(1), OPRK1(6), OPRL1(6), OPRM1(3), OR10A5(5), OR11A1(5), OR12D3(1), OR1C1(2), OR1F1(3), OR1Q1(5), OR2H1(2), OR5V1(6), OR7C1(2), OR8B8(5), OXTR(5), P2RY1(3), P2RY10(10), P2RY12(6), P2RY13(2), P2RY14(4), P2RY2(5), P2RY6(6), PPYR1(6), PTAFR(5), PTGDR(6), PTGER2(4), PTGER4(4), PTGFR(3), RGR(1), RHO(6), RRH(2), SSTR1(9), SSTR2(3), SSTR3(5), SSTR4(11), SUCNR1(4), TBXA2R(8), TRHR(4) 39086266 635 145 627 252 242 175 25 151 42 0 0.0669 1.000 1.000 211 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 140 APC(35), APC2(12), AXIN1(8), AXIN2(4), BTRC(5), CACYBP(2), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CCND1(1), CCND2(3), CCND3(2), CER1(2), CHD8(15), CREBBP(27), CSNK1A1(3), CSNK1A1L(2), CSNK1E(7), CSNK2A1(8), CSNK2A2(4), CSNK2B(1), CTBP1(3), CTBP2(5), CTNNBIP1(1), CUL1(14), CXXC4(2), DAAM1(9), DAAM2(12), DKK1(7), DKK2(4), DKK4(1), DVL1(5), DVL2(3), DVL3(8), EP300(19), FBXW11(10), FZD1(7), FZD10(14), FZD2(7), FZD3(5), FZD4(4), FZD5(3), FZD6(5), FZD7(4), FZD8(6), FZD9(2), GSK3B(4), JUN(3), LEF1(5), LRP5(12), LRP6(6), MAP3K7(8), MAPK10(5), MAPK8(5), MAPK9(4), MMP7(2), MYC(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), NKD1(5), NKD2(1), NLK(6), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PORCN(3), PPARD(7), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRICKLE1(13), PRICKLE2(16), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), PSEN1(2), RAC2(2), RAC3(3), RBX1(1), ROCK1(9), ROCK2(7), RUVBL1(7), SENP2(2), SFRP1(4), SFRP2(4), SFRP4(3), SFRP5(1), SIAH1(1), SMAD2(8), SMAD3(3), SOX17(5), TBL1X(5), TBL1XR1(2), TBL1Y(1), TCF7(3), TCF7L1(3), TCF7L2(8), VANGL1(2), VANGL2(4), WIF1(2), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT3A(4), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6), WNT8A(1), WNT8B(1), WNT9A(3), WNT9B(3) 51559454 742 145 726 237 287 194 25 135 96 5 0.000484 1.000 1.000 212 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(6), ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ADK(2), ADSL(3), ADSS(4), ADSSL1(7), AK1(1), AK5(3), AK7(3), ALLC(5), AMPD1(8), AMPD2(7), AMPD3(13), APRT(2), ATIC(6), CANT1(3), DGUOK(2), ENPP1(5), ENPP3(4), ENTPD1(5), ENTPD3(4), ENTPD4(7), ENTPD6(2), ENTPD8(6), GART(8), GDA(2), GMPR(1), GMPR2(2), GMPS(4), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(8), GUCY2D(12), GUCY2F(13), GUK1(3), IMPDH1(5), IMPDH2(3), NME6(2), NME7(1), NPR1(9), NPR2(7), NT5C(1), NT5C1A(4), NT5C1B(5), NT5C2(7), NT5C3(1), NUDT2(3), NUDT5(1), NUDT9(1), PAICS(1), PAPSS1(4), PAPSS2(4), PDE10A(7), PDE11A(6), PDE1A(6), PDE1C(5), PDE2A(8), PDE3B(13), PDE4A(7), PDE4B(4), PDE4C(4), PDE4D(1), PDE5A(6), PDE6G(1), PDE7A(4), PDE7B(2), PDE8A(8), PDE8B(4), PDE9A(4), PFAS(5), PKLR(5), PKM2(5), PNPT1(4), POLA1(5), POLA2(3), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), POLE3(1), POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3A(15), POLR3B(9), POLR3G(2), POLR3K(1), PPAT(3), PRIM1(2), PRIM2(6), PRPS1(2), PRPS1L1(2), PRPS2(2), PRUNE(3), RFC5(1), RRM1(5), RRM2(3), RRM2B(4), XDH(11) 53568441 624 140 617 241 214 182 24 153 51 0 0.435 1.000 1.000 213 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ADRB1(7), CSNK1D(2), DRD1(3), DRD2(7), EGF(8), EGFR(11), GJA1(9), GJD2(3), GNA11(5), GNAI1(1), GNAI2(2), GNAI3(6), GNAQ(3), GNAS(20), GRB2(4), GRM1(26), GRM5(23), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(8), GUCY2D(12), GUCY2F(13), HTR2A(5), HTR2B(4), HTR2C(5), ITPR1(21), ITPR2(21), ITPR3(31), MAP2K1(5), MAP2K2(2), MAP2K5(1), MAP3K2(3), MAPK1(2), MAPK3(1), MAPK7(7), NPR1(9), NPR2(7), NRAS(2), PDGFA(2), PDGFB(5), PDGFC(5), PDGFD(5), PDGFRA(11), PDGFRB(10), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKG1(8), PRKG2(10), PRKX(4), RAF1(7), SOS1(6), SOS2(11), SRC(2), TJP1(11), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(5), TUBA3D(4), TUBA3E(9), TUBA4A(1), TUBA8(4), TUBAL3(4), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB3(12), TUBB4(4), TUBB4Q(4), TUBB6(7), TUBB8(3) 43212447 656 137 643 256 238 177 26 166 48 1 0.418 1.000 1.000 214 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(3), AKT2(6), AKT3(6), CBL(2), CBLB(3), CBLC(2), CCND1(1), CCND2(3), CCND3(2), CISH(1), CLCF1(2), CNTF(3), CNTFR(2), CREBBP(27), CSF2RA(8), CSF2RB(7), CSF3(1), CSF3R(6), EP300(19), EPOR(2), GH1(1), GH2(3), GHR(6), GRB2(4), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IFNG(2), IFNGR1(5), IFNGR2(1), IFNK(1), IFNW1(2), IL10(2), IL10RA(4), IL10RB(2), IL11(2), IL11RA(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL13(1), IL13RA1(3), IL13RA2(6), IL15RA(3), IL20(1), IL20RA(6), IL21(2), IL21R(9), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(5), IL26(4), IL28A(2), IL28B(3), IL28RA(1), IL2RA(2), IL2RB(2), IL2RG(5), IL3(1), IL3RA(5), IL4(1), IL4R(1), IL5RA(4), IL6R(1), IL6ST(4), IL7(1), IL7R(6), IL9R(3), IRF9(3), JAK1(6), JAK2(10), JAK3(9), LEPR(13), LIF(1), LIFR(10), MYC(3), OSM(2), OSMR(4), PIAS1(6), PIAS2(7), PIAS3(2), PIAS4(5), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIM1(2), PRL(1), PRLR(2), PTPN11(5), PTPN6(3), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SOCS5(7), SOCS7(3), SOS1(6), SOS2(11), SPRED1(10), SPRED2(6), SPRY1(2), SPRY3(6), SPRY4(4), STAM(5), STAM2(4), STAT1(7), STAT2(4), STAT3(7), STAT4(3), STAT5A(4), STAT5B(6), STAT6(1), TPO(15), TSLP(3), TYK2(4) 46956110 561 135 548 195 172 161 28 143 57 0 0.0992 1.000 1.000 215 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(8), BRAF(9), C7orf16(3), CACNA1A(16), CRHR1(10), GNA11(5), GNA12(1), GNA13(3), GNAI1(1), GNAI2(2), GNAI3(6), GNAQ(3), GNAS(20), GNAZ(11), GRIA1(17), GRIA2(17), GRIA3(6), GRID2(14), GRM1(26), GRM5(23), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(8), GUCY2D(12), GUCY2F(13), IGF1(4), IGF1R(15), ITPR1(21), ITPR2(21), ITPR3(31), LYN(4), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), NOS1(22), NOS3(5), NPR1(9), NPR2(7), NRAS(2), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), PRKCA(3), PRKCG(13), PRKG1(8), PRKG2(10), RAF1(7), RYR1(43) 35990158 594 134 582 190 227 144 25 154 43 1 0.0117 1.000 1.000 216 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(4), ANAPC1(11), ANAPC10(1), ANAPC11(1), ANAPC2(4), ANAPC5(2), ANAPC7(3), ATM(30), ATR(13), BUB1(10), BUB1B(7), BUB3(2), CCNA1(7), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(16), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CCNH(2), CDC14A(7), CDC14B(2), CDC16(4), CDC20(4), CDC23(4), CDC25A(3), CDC25B(4), CDC25C(7), CDC26(1), CDC27(2), CDC6(5), CDC7(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(8), CDKN2D(3), CHEK1(4), CHEK2(7), CREBBP(27), CUL1(14), DBF4(6), E2F1(2), E2F2(3), E2F3(2), EP300(19), ESPL1(15), FZR1(3), GSK3B(4), HDAC1(3), HDAC2(2), MAD1L1(8), MAD2L1(1), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), MDM2(3), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PKMYT1(3), PLK1(6), PRKDC(32), PTTG1(1), PTTG2(3), RB1(6), RBL1(7), RBL2(4), RBX1(1), SKP2(5), SMAD2(8), SMAD3(3), SMC1A(5), SMC1B(8), TFDP1(3), TGFB1(3), TGFB2(6), TGFB3(5), WEE1(2), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2) 44011961 496 132 486 168 150 143 19 120 62 2 0.203 1.000 1.000 217 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 71 ACTB(7), ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), ACVR1B(12), ACVR1C(3), BAIAP2(4), CDC42(1), CREBBP(27), CSNK2A1(8), CSNK2A2(4), CSNK2B(1), CTNNA1(11), CTNNA2(16), CTNNA3(9), CTNND1(13), EGFR(11), EP300(19), ERBB2(12), FARP2(3), FER(9), FGFR1(11), FYN(8), IGF1R(15), INSR(12), IQGAP1(11), LEF1(5), LMO7(11), MAP3K7(8), MAPK1(2), MAPK3(1), MET(7), MLLT4(18), NLK(6), PARD3(9), PTPN1(2), PTPN6(3), PTPRB(17), PTPRF(15), PTPRJ(21), PTPRM(25), PVRL1(1), PVRL2(4), PVRL3(4), PVRL4(6), RAC2(2), RAC3(3), SMAD2(8), SMAD3(3), SNAI1(3), SNAI2(8), SORBS1(7), SRC(2), SSX2IP(6), TCF7(3), TCF7L1(3), TCF7L2(8), TGFBR1(5), TGFBR2(11), TJP1(11), VCL(1), WAS(1), WASF1(3), WASF2(6), WASF3(6), WASL(2), YES1(2) 37750756 532 131 518 183 171 162 18 105 76 0 0.0568 1.000 1.000 218 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(19), ACACB(22), AKT1(3), AKT2(6), AKT3(6), ARAF(8), BAD(3), BRAF(9), CALM1(1), CALM2(3), CALML3(1), CBL(2), CBLB(3), CBLC(2), CRK(1), CRKL(1), EIF4EBP1(2), ELK1(3), EXOC7(7), FASN(14), FBP1(2), FBP2(4), FLOT1(2), FLOT2(3), FOXO1(3), G6PC2(1), GCK(4), GRB2(4), GSK3B(4), GYS1(3), GYS2(4), IKBKB(7), INPP5D(1), INSR(12), IRS1(15), IRS2(4), IRS4(16), LIPE(6), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(4), MKNK1(3), MKNK2(1), NRAS(2), PCK1(6), PCK2(7), PDE3A(11), PDE3B(13), PDPK1(2), PFKL(4), PFKM(3), PFKP(8), PHKA1(7), PHKA2(9), PHKB(1), PHKG1(2), PHKG2(7), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PKLR(5), PKM2(5), PPARGC1A(9), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R3A(21), PPP1R3B(6), PPP1R3C(3), PPP1R3D(2), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAG2(3), PRKAG3(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCI(4), PRKX(4), PTPN1(2), PTPRF(15), PYGB(8), PYGL(6), PYGM(9), RAF1(7), RAPGEF1(9), RHEB(1), RPS6(1), RPS6KB1(4), RPS6KB2(3), SH2B2(2), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SLC2A4(4), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SORBS1(7), SOS1(6), SOS2(11), SREBF1(8), TRIP10(7), TSC1(3), TSC2(7) 51557428 635 131 625 240 244 169 19 131 72 0 0.165 1.000 1.000 219 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 82 ABL1(4), ABL2(6), AKT1(3), AKT2(6), AKT3(6), ARAF(8), BAD(3), BRAF(9), BTC(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CBL(2), CBLB(3), CBLC(2), CDKN1A(1), CRK(1), CRKL(1), EGF(8), EGFR(11), EIF4EBP1(2), ELK1(3), ERBB2(12), ERBB3(29), ERBB4(33), EREG(3), GAB1(2), GRB2(4), GSK3B(4), HBEGF(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K4(7), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(4), MYC(3), NCK1(6), NCK2(3), NRAS(2), NRG1(11), NRG2(6), NRG3(13), NRG4(1), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PLCG2(11), PRKCA(3), PRKCG(13), PTK2(10), RAF1(7), RPS6KB1(4), RPS6KB2(3), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SOS1(6), SOS2(11), SRC(2), STAT5A(4), STAT5B(6), TGFA(2) 32662443 464 128 443 151 164 124 21 105 50 0 0.0366 1.000 1.000 220 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), AKAP1(2), AKAP10(3), AKAP11(9), AKAP12(9), AKAP3(8), AKAP4(10), AKAP5(2), AKAP6(18), AKAP7(2), AKAP8(9), AKAP9(29), ARHGEF1(9), CALM1(1), CALM2(3), CHMP1B(1), GNA11(5), GNA12(1), GNA13(3), GNA14(3), GNA15(3), GNAI2(2), GNAI3(6), GNAL(2), GNAQ(3), GNAZ(11), GNB2(4), GNG12(1), GNG13(2), GNG7(3), GNGT1(3), GNGT2(2), ITPR1(21), KCNJ3(9), NRAS(2), PDE1A(6), PDE1B(3), PDE1C(5), PDE4A(7), PDE4B(4), PDE4C(4), PDE4D(1), PDE7A(4), PDE7B(2), PDE8A(8), PDE8B(4), PLCB3(8), PPP3CA(5), PPP3CC(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCI(4), PRKCQ(7), PRKD1(16), PRKD3(4), RRAS(1), SLC9A1(8), USP5(4) 38075867 472 125 464 182 148 143 21 107 52 1 0.301 1.000 1.000 221 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(6), ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADK(2), ADSL(3), ADSS(4), AK1(1), AK5(3), ALLC(5), AMPD1(8), AMPD2(7), AMPD3(13), APRT(2), ATIC(6), ATP1B1(1), ATP5A1(2), ATP5B(3), ATP5C1(3), ATP5F1(1), ATP5G2(1), ATP5J(1), ATP5J2(1), CANT1(3), DGUOK(2), ENPP1(5), ENPP3(4), ENTPD1(5), GART(8), GDA(2), GMPS(4), GUCY1A2(8), GUCY1A3(14), GUCY1B3(7), GUCY2C(8), GUCY2D(12), GUCY2F(13), GUK1(3), IMPDH1(5), IMPDH2(3), NPR1(9), NPR2(7), NT5C(1), NUDT2(3), PAICS(1), PAPSS1(4), PAPSS2(4), PDE1A(6), PDE4A(7), PDE4B(4), PDE4C(4), PDE4D(1), PDE5A(6), PDE6B(8), PDE6C(3), PDE6G(1), PDE7B(2), PDE8A(8), PDE9A(4), PFAS(5), PKLR(5), PKM2(5), POLB(2), POLD1(10), POLD2(1), POLE(17), POLG(5), POLL(2), POLQ(22), POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLRMT(10), PPAT(3), PRPS1(2), PRPS1L1(2), PRPS2(2), PRUNE(3), RRM1(5), RRM2(3) 42009235 495 124 490 193 159 149 21 127 39 0 0.503 1.000 1.000 222 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(4), ATM(30), BUB1(10), BUB1B(7), BUB3(2), CCNA1(7), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(16), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CCNH(2), CDAN1(7), CDC14A(7), CDC14B(2), CDC20(4), CDC25A(3), CDC25B(4), CDC25C(7), CDC6(5), CDC7(3), CDK2(3), CDKN1A(1), CDKN2A(8), CHEK1(4), CHEK2(7), DTX4(6), E2F1(2), E2F2(3), E2F3(2), E2F4(1), E2F5(1), E2F6(2), EP300(19), ESPL1(15), GSK3B(4), HDAC1(3), HDAC2(2), HDAC3(4), HDAC4(13), HDAC5(6), HDAC6(7), HDAC8(3), MAD1L1(8), MAD2L1(1), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), MDM2(3), MPEG1(6), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PLK1(6), PRKDC(32), PTPRA(7), PTTG1(1), PTTG2(3), RB1(6), RBL1(7), SKP2(5), TBC1D8(7), TFDP1(3), TGFB1(3), WEE1(2) 34922706 409 123 403 139 122 117 20 99 49 2 0.186 1.000 1.000 223 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(16), ADCY8(21), ARAF(8), BRAF(9), CACNA1C(27), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CREBBP(27), EP300(19), GNAQ(3), GRIA1(17), GRIA2(17), GRIN1(4), GRIN2A(11), GRIN2B(18), GRIN2C(4), GRIN2D(4), GRM1(26), GRM5(23), ITPR1(21), ITPR2(21), ITPR3(31), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), NRAS(2), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PPP1CA(2), PPP1CB(1), PPP1CC(4), PPP1R12A(2), PPP1R1A(1), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), RAF1(7), RAP1A(2), RAP1B(5), RAPGEF3(2), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3) 32039107 486 121 475 181 178 135 11 105 56 1 0.154 1.000 1.000 224 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(6), BCAR1(4), CAPN1(2), CAPN10(3), CAPN11(2), CAPN2(3), CAPN3(9), CAPN5(3), CAPN6(5), CAPN7(5), CAPN9(2), CAPNS1(2), CAV1(4), CAV2(2), CAV3(2), CDC42(1), CRK(1), CSK(5), DOCK1(15), FYN(8), GIT2(1), GRB2(4), ILK(3), ITGA10(6), ITGA11(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGAD(9), ITGAE(6), ITGAL(11), ITGAM(6), ITGAV(5), ITGAX(8), ITGB1(6), ITGB2(5), ITGB3(3), ITGB4(12), ITGB5(5), ITGB6(3), ITGB7(4), ITGB8(8), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K6(1), MAPK10(5), MAPK4(6), MAPK6(1), MAPK7(7), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PDPK1(2), PIK3R2(8), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAP1B(5), RAPGEF1(9), RHO(6), ROCK1(9), ROCK2(7), SDCCAG8(3), SHC1(3), SHC3(8), SORBS1(7), SOS1(6), SRC(2), TLN1(14), TNS1(22), VASP(2), VAV2(11), VAV3(10), VCL(1), ZYX(5) 43935585 474 121 467 198 165 120 24 107 57 1 0.777 1.000 1.000 225 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(5), ACVR1B(12), ACVRL1(3), AKT1(3), AURKB(4), BMPR1A(3), BMPR2(11), BUB1(10), CDIPT(1), CDKL1(2), CDKL2(3), CDS1(4), CDS2(2), CLK1(3), CLK2(8), CLK4(2), COL4A3BP(3), CSNK2A1(8), CSNK2A2(4), CSNK2B(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKZ(4), IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(5), INPPL1(14), ITPKA(1), ITPKB(7), MAP3K10(8), MOS(9), NEK1(4), NEK3(1), OCRL(8), PAK4(6), PIK3C2A(8), PIK3C2B(15), PIK3C2G(7), PIK3CB(7), PIK3CG(15), PIM2(2), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCG1(16), PLCG2(11), PLK3(4), PRKACA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCQ(7), PRKD1(16), PRKG1(8), RAF1(7), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA4(1), RPS6KB1(4), STK11(2), TGFBR1(5), VRK1(1) 36289666 454 121 438 154 141 131 20 104 55 3 0.146 1.000 1.000 226 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(16), BDKRB1(1), BDKRB2(3), C1QA(1), C1QC(2), C1R(3), C1S(5), C2(2), C3(21), C3AR1(5), C4BPA(1), C4BPB(2), C5(11), C5AR1(5), C6(10), C7(2), C8A(5), C8B(12), C9(6), CD46(2), CD55(2), CFB(5), CFH(12), CFI(9), CPB2(6), CR1(24), CR2(8), F10(6), F11(3), F12(2), F13A1(10), F13B(13), F2(5), F2R(2), F3(1), F5(13), F7(9), F8(15), F9(6), FGA(7), FGB(2), FGG(2), KLKB1(7), KNG1(8), MASP1(3), MASP2(4), MBL2(1), PLAT(4), PLAU(2), PLAUR(3), PLG(11), PROC(2), PROS1(8), SERPINA1(3), SERPINA5(5), SERPINC1(4), SERPIND1(3), SERPINE1(3), SERPINF2(5), SERPING1(5), TFPI(3), THBD(1), VWF(19) 29731419 381 120 374 123 111 104 20 102 41 3 0.0694 1.000 1.000 227 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), CACNA1C(27), CACNA1D(21), CACNA1F(9), CACNA1S(12), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CDC42(1), CGA(1), EGFR(11), ELK1(3), FSHB(1), GNA11(5), GNAQ(3), GNAS(20), GNRH1(1), GNRH2(2), GNRHR(4), GRB2(4), HBEGF(2), ITPR1(21), ITPR2(21), ITPR3(31), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(7), MAPK8(5), MAPK9(4), MMP2(3), NRAS(2), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLD1(13), PLD2(13), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCD(7), PRKX(4), PTK2B(10), RAF1(7), SOS1(6), SOS2(11), SRC(2) 41355188 555 120 546 212 215 144 22 116 57 1 0.272 1.000 1.000 228 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 107 ACTN1(6), ACTN2(22), ACTN3(2), ACTN4(6), ARHGAP5(11), BCAR1(4), CD99(1), CDC42(1), CDH5(5), CLDN1(2), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(4), CLDN18(2), CLDN19(3), CLDN20(3), CLDN22(2), CLDN23(2), CLDN3(1), CLDN4(5), CLDN5(2), CLDN6(4), CLDN8(1), CLDN9(3), CTNNA1(11), CTNNA2(16), CTNNA3(9), CTNND1(13), CXCR4(1), CYBB(6), ESAM(5), EZR(3), F11R(2), GNAI1(1), GNAI2(2), GNAI3(6), GRLF1(15), ICAM1(1), ITGA4(9), ITGAL(11), ITGAM(6), ITGB1(6), ITGB2(5), ITK(5), JAM2(2), JAM3(4), MAPK11(1), MAPK13(1), MAPK14(1), MLLT4(18), MMP2(3), MMP9(13), MSN(9), MYL2(6), MYL7(1), MYL9(2), NCF1(3), NCF2(2), NOX1(4), NOX3(3), OCLN(4), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PLCG2(11), PRKCA(3), PRKCG(13), PTK2(10), PTK2B(10), PTPN11(5), PXN(3), RAC2(2), RAP1A(2), RAP1B(5), RAPGEF3(2), RAPGEF4(7), RASSF5(2), RHOH(2), ROCK1(9), ROCK2(7), SIPA1(1), THY1(1), TXK(2), VASP(2), VAV1(6), VAV2(11), VAV3(10), VCAM1(8), VCL(1) 39354932 523 118 514 213 195 135 21 100 70 2 0.611 1.000 1.000 229 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(3), AKT2(6), AKT3(6), BAD(3), CDC42(1), CDK2(3), CDKN2A(8), CREB1(3), CREB3(4), CREB5(4), EBP(1), ERBB4(33), F2RL2(2), GAB1(2), GRB2(4), GSK3A(2), GSK3B(4), IGF1(4), IGFBP1(5), INPPL1(14), IRS1(15), IRS2(4), IRS4(16), MET(7), MYC(3), NOLC1(6), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PARD3(9), PARD6A(1), PDK1(2), PIK3CD(10), PPP1R13B(6), PREX1(13), PTK2(10), PTPN1(2), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SHC1(3), SLC2A4(4), SOS1(6), SOS2(11), TSC1(3), TSC2(7), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2) 24387691 314 118 309 101 110 84 15 60 45 0 0.0447 1.000 1.000 230 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(4), ACTN1(6), ACTR2(2), ACTR3(2), AKT1(3), AKT2(6), AKT3(6), ANGPTL2(3), ARHGEF6(12), ARHGEF7(7), BCAR1(4), BRAF(9), CAV1(4), CDC42(1), CDKN2A(8), CRK(1), CSE1L(2), DOCK1(15), EPHB2(8), FYN(8), GRB2(4), GRB7(7), GRLF1(15), ILK(3), ITGA1(7), ITGA10(6), ITGA11(7), ITGA2(5), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGA7(7), ITGA8(5), ITGA9(7), ITGB3BP(1), MAP2K4(7), MAP3K11(7), MAPK1(2), MAPK10(5), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MYLK(15), MYLK2(2), P4HB(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PIK3CB(7), PKLR(5), PLCG1(16), PLCG2(11), PTK2(10), RAF1(7), RHO(6), ROCK1(9), ROCK2(7), SHC1(3), SOS1(6), SOS2(11), SRC(2), TERF2IP(4), TLN1(14), TLN2(21), VASP(2), WAS(1), ZYX(5) 38933566 453 118 447 163 162 116 18 96 60 1 0.276 1.000 1.000 231 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALM1(1), CALM2(3), CALML3(1), CDIPT(1), CDS1(4), CDS2(2), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKI(9), DGKZ(4), FN3K(2), IMPA1(3), IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(5), INPP5B(7), INPP5D(1), INPP5E(6), INPPL1(14), ITGB1BP3(2), ITPK1(4), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(21), ITPR3(31), OCRL(8), PI4KA(11), PI4KB(3), PIK3C2A(8), PIK3C2B(15), PIK3C2G(7), PIK3C3(10), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1B(1), PIP5K1C(8), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCD3(8), PLCD4(2), PLCE1(11), PLCG1(16), PLCG2(11), PLCZ1(3), PRKCA(3), PRKCG(13), PTPMT1(1), SYNJ1(7), SYNJ2(9) 39867984 452 117 440 155 171 126 15 94 44 2 0.0469 1.000 1.000 232 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 123 ARAF(8), BID(2), BRAF(9), CASP3(2), CD244(2), CD247(3), FAS(3), FASLG(2), FCGR3A(3), FCGR3B(3), FYN(8), GRB2(4), GZMB(2), HCST(1), HLA-A(7), HLA-C(3), HLA-E(3), HLA-G(3), ICAM1(1), ICAM2(2), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IFNG(2), IFNGR1(5), IFNGR2(1), ITGAL(11), ITGB2(5), KIR2DL1(5), KIR2DL3(2), KIR2DL4(3), KIR3DL1(5), KIR3DL2(1), KLRC1(3), KLRC2(2), KLRC3(4), KLRD1(4), LAT(2), LCK(3), LCP2(5), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MICA(2), MICB(2), NCR1(3), NCR2(4), NCR3(1), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), NRAS(2), PAK1(5), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PLCG2(11), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRF1(1), PRKCA(3), PRKCG(13), PTK2B(10), PTPN11(5), PTPN6(3), RAC2(2), RAC3(3), RAF1(7), SH2D1A(1), SH2D1B(1), SH3BP2(3), SHC1(3), SHC2(2), SHC3(8), SHC4(1), SOS1(6), SOS2(11), SYK(6), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(3), TNFSF10(3), ULBP1(2), ULBP3(1), VAV1(6), VAV2(11), VAV3(10), ZAP70(10) 36108946 495 117 483 160 158 139 16 119 63 0 0.0142 1.000 1.000 233 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(1), ALG1(5), ALG10(6), ALG10B(3), ALG12(3), ALG13(7), ALG14(1), ALG3(2), ALG6(2), ALG8(1), ALG9(1), B3GNT1(3), B3GNT2(2), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), B4GALT5(5), B4GALT7(2), C1GALT1(3), C1GALT1C1(4), CHPF(2), CHST1(13), CHST11(2), CHST12(4), CHST13(2), CHST14(2), CHST2(10), CHST3(3), CHST4(4), CHST6(6), CHST7(7), CHSY1(4), DPAGT1(1), EXT1(16), EXT2(5), EXTL1(4), EXTL2(2), EXTL3(10), FUT11(3), FUT8(3), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(7), GALNT14(6), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(7), GALNT6(2), GALNT8(5), GALNT9(2), GALNTL1(7), GALNTL2(8), GALNTL4(7), GALNTL5(3), GANAB(4), GCNT3(2), GCNT4(2), HS2ST1(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), HS3ST5(6), HS6ST1(2), HS6ST2(4), HS6ST3(6), MAN1A1(2), MAN1A2(3), MAN1B1(5), MAN1C1(2), MAN2A1(3), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(3), MGAT5(8), MGAT5B(4), NDST1(10), NDST2(6), NDST3(10), NDST4(13), OGT(2), RPN1(2), RPN2(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4), ST6GALNAC1(2), STT3B(3), UST(7), XYLT1(8), XYLT2(7) 35680064 414 116 408 171 155 113 17 90 38 1 0.716 1.000 1.000 234 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1(5), ACVR1B(12), ACVR1C(3), ACVR2A(6), ACVR2B(3), ACVRL1(3), AMHR2(2), BMP2(2), BMP4(4), BMP5(9), BMP6(7), BMP7(5), BMP8A(1), BMP8B(2), BMPR1A(3), BMPR1B(4), BMPR2(11), CHRD(6), COMP(2), CREBBP(27), CUL1(14), DCN(5), E2F4(1), E2F5(1), EP300(19), FST(2), GDF5(7), GDF6(11), GDF7(2), ID3(1), IFNG(2), INHBA(7), INHBB(8), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(15), MAPK1(2), MAPK3(1), MYC(3), PITX2(4), PPP2CA(3), PPP2CB(2), PPP2R1A(9), PPP2R1B(4), PPP2R2A(5), PPP2R2B(5), PPP2R2C(5), RBL1(7), RBL2(4), RBX1(1), ROCK1(9), ROCK2(7), RPS6KB1(4), RPS6KB2(3), SMAD1(2), SMAD2(8), SMAD3(3), SMAD5(2), SMAD6(5), SMAD7(3), SMAD9(8), SMURF1(3), SMURF2(3), SP1(6), TFDP1(3), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), THBS1(12), THBS2(7), THBS3(6), THBS4(10), TNF(1), ZFYVE16(7), ZFYVE9(5) 31911395 421 116 413 172 148 116 22 74 58 3 0.597 1.000 1.000 235 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(28), ASH2L(4), C17orf79(1), CARM1(4), CTCFL(7), DOT1L(8), EHMT1(10), EHMT2(6), EZH1(4), EZH2(5), FBXO11(9), HCFC1(15), HSF4(4), JMJD4(1), JMJD6(2), KDM6A(9), MEN1(6), MLL(22), MLL2(46), MLL3(53), MLL4(26), MLL5(15), NSD1(17), OGT(2), PAXIP1(4), PPP1CA(2), PPP1CB(1), PPP1CC(4), PRDM2(22), PRDM7(1), PRDM9(15), PRMT1(2), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), RBBP5(1), SATB1(11), SETD1A(9), SETD2(11), SETD7(1), SETDB1(13), SETDB2(6), SMYD3(3), STK38(4), SUV39H1(5), SUV39H2(2), SUV420H1(9), SUV420H2(3), SUZ12(3), WHSC1(12), WHSC1L1(9) 38964491 468 114 462 159 144 130 13 97 76 8 0.269 1.000 1.000 236 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 96 ADCY1(16), ADCY2(12), ADCY3(5), ADCY4(5), ADCY5(11), ADCY6(10), ADCY7(13), ADCY8(21), ADCY9(8), ASIP(1), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CREB1(3), CREB3(4), CREB3L1(3), CREB3L2(3), CREB3L3(3), CREB3L4(1), CREBBP(27), DCT(8), DVL1(5), DVL2(3), DVL3(8), EDN1(2), EP300(19), FZD1(7), FZD10(14), FZD2(7), FZD3(5), FZD4(4), FZD5(3), FZD6(5), FZD7(4), FZD8(6), FZD9(2), GNAI1(1), GNAI2(2), GNAI3(6), GNAQ(3), GNAS(20), GSK3B(4), KIT(12), KITLG(2), LEF1(5), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MITF(8), NRAS(2), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), POMC(6), PRKACA(3), PRKACB(2), PRKACG(5), PRKCA(3), PRKCG(13), PRKX(4), RAF1(7), TCF7(3), TCF7L1(3), TCF7L2(8), TYR(6), TYRP1(3), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT3A(4), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6), WNT8A(1), WNT8B(1), WNT9A(3), WNT9B(3) 34661186 504 114 496 207 204 138 15 101 45 1 0.309 1.000 1.000 237 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 89 AKT1(3), AKT2(6), AKT3(6), BCL10(1), CARD11(15), CBL(2), CBLB(3), CBLC(2), CD247(3), CD3E(2), CD4(5), CD40LG(4), CD8A(4), CD8B(2), CDC42(1), CTLA4(3), FOS(1), FYN(8), GRAP2(4), GRB2(4), ICOS(1), IFNG(2), IKBKB(7), IL10(2), IL4(1), ITK(5), JUN(3), LAT(2), LCK(3), LCP2(5), MALT1(4), MAP3K14(3), NCK1(6), NCK2(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NRAS(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PDCD1(2), PDK1(2), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKCQ(7), PTPN6(3), PTPRC(15), RASGRP1(5), SOS1(6), SOS2(11), TEC(4), TNF(1), VAV1(6), VAV2(11), VAV3(10), ZAP70(10) 32307493 412 111 404 146 142 115 16 90 49 0 0.180 1.000 1.000 238 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(13), AMY2A(3), ASCC3(24), ATP13A2(10), DDX18(8), DDX19A(4), DDX23(7), DDX4(4), DDX41(7), DDX47(2), DDX50(6), DDX51(2), DDX52(1), DDX54(13), DDX55(3), DDX56(4), DHX58(7), ENPP1(5), ENPP3(4), ENTPD7(9), EP400(25), ERCC2(5), ERCC3(7), G6PC2(1), GAA(2), GANC(7), GBA(6), GBA3(1), GBE1(3), GCK(4), GPI(5), GUSB(8), GYS1(3), GYS2(4), HK1(11), HK2(9), HK3(5), IFIH1(5), LYZL1(4), MGAM(9), MOV10L1(3), NUDT5(1), PGM1(2), PGM3(10), PYGB(8), PYGL(6), PYGM(9), RAD54B(3), RAD54L(4), RUVBL2(2), SETX(12), SI(19), SKIV2L2(7), SMARCA2(16), SMARCA5(3), TREH(3), UGDH(5), UGP2(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(11), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), UXS1(3) 40226518 430 110 428 162 132 136 14 107 41 0 0.412 1.000 1.000 239 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(13), ABCA10(14), ABCA12(26), ABCA13(37), ABCA2(13), ABCA3(14), ABCA4(13), ABCA5(12), ABCA6(7), ABCA7(6), ABCA8(10), ABCA9(12), ABCB1(18), ABCB10(11), ABCB11(8), ABCB4(17), ABCB5(9), ABCB6(4), ABCB7(2), ABCB8(4), ABCB9(3), ABCC1(9), ABCC10(5), ABCC11(14), ABCC12(14), ABCC2(11), ABCC3(8), ABCC4(11), ABCC5(8), ABCC6(9), ABCC8(13), ABCC9(30), ABCD1(6), ABCD2(2), ABCD3(4), ABCD4(6), ABCG1(7), ABCG2(3), ABCG4(4), ABCG8(5), CFTR(8), TAP1(2), TAP2(10) 38721408 442 110 435 167 130 143 16 105 47 1 0.219 1.000 1.000 240 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT1(3), AKT2(6), AKT3(6), CASP8(8), CCL5(1), CD14(2), CD40(1), CD80(1), CD86(2), CXCL10(1), CXCL9(2), FOS(1), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), IFNAR1(5), IFNAR2(6), IFNB1(2), IKBKB(7), IKBKE(8), IL12A(2), IL12B(1), IL1B(2), IL8(1), IRAK1(6), IRAK4(2), IRF5(3), IRF7(1), JUN(3), LBP(1), LY96(1), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K7(8), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), MAPK9(4), MYD88(1), NFKB1(7), NFKB2(2), NFKBIA(1), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), RELA(3), RIPK1(1), SPP1(3), STAT1(7), TBK1(5), TICAM1(9), TIRAP(1), TLR1(5), TLR2(1), TLR3(5), TLR4(18), TLR5(8), TLR6(1), TLR7(5), TLR8(10), TLR9(13), TNF(1), TOLLIP(2), TRAF3(3), TRAF6(5) 28463223 336 108 323 124 104 85 17 89 41 0 0.379 1.000 1.000 241 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(4), ALG6(2), CCKBR(6), CCR2(5), CCR3(6), CCR5(3), CELSR1(23), CELSR2(17), CELSR3(30), CHRM2(13), CHRM3(9), CIDEB(2), DRD4(2), EDNRA(3), EMR2(9), EMR3(4), F2R(2), GHRHR(4), GNRHR(4), GPR116(11), GPR132(2), GPR133(9), GPR135(7), GPR143(4), GPR17(1), GPR18(2), GPR55(7), GPR56(4), GPR61(6), GPR77(1), GPR84(1), GRM1(26), GRPR(7), HRH4(3), LGR6(10), LPHN2(17), LPHN3(14), LTB4R2(2), NTSR1(5), OR2M4(5), OR8G2(5), P2RY13(2), PTGFR(3), SMO(10), SSTR2(3), TAAR5(5), TSHR(8), VN1R1(2) 21352906 330 107 327 121 111 92 16 89 22 0 0.134 1.000 1.000 242 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(7), BAD(3), BCL2(2), CABIN1(13), CALM1(1), CALM2(3), CAMK2B(2), CAMK4(6), CD3E(2), CDKN1A(1), CNR1(7), CREBBP(27), CSNK2A1(8), CSNK2B(1), CTLA4(3), EGR2(6), EGR3(5), EP300(19), FCER1A(2), FCGR3A(3), FOS(1), GATA3(8), GATA4(4), GRLF1(15), GSK3A(2), GSK3B(4), ICOS(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL13(1), IL1B(2), IL2RA(2), IL3(1), IL4(1), IL8(1), ITK(5), JUNB(1), KPNA5(4), MAPK14(1), MAPK8(5), MAPK9(4), MEF2A(1), MEF2B(4), MEF2D(6), MYF5(3), NCK2(3), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), NFKB2(2), NFKBIB(5), NPPB(2), NUP214(15), OPRD1(1), P2RX7(1), PAK1(5), PIN1(1), PPP3CB(6), PPP3CC(3), PTPRC(15), RELA(3), RPL13A(2), SLA(2), SP1(6), SP3(3), TGFB1(3), TNF(1), TRAF2(2), TRPV6(6), VAV1(6), VAV2(11), VAV3(10), XPO5(3) 29656458 373 106 369 144 124 116 12 78 43 0 0.355 1.000 1.000 243 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(6), CD14(2), CD19(3), CD1A(6), CD1B(5), CD1C(5), CD1D(7), CD1E(7), CD2(2), CD22(3), CD33(7), CD34(3), CD36(2), CD37(2), CD38(3), CD3E(2), CD4(5), CD44(4), CD5(4), CD55(2), CD7(3), CD8A(4), CD8B(2), CD9(1), CR1(24), CR2(8), CSF1(1), CSF1R(7), CSF2RA(8), CSF3(1), CSF3R(6), DNTT(2), EPOR(2), FCER2(1), FLT3(8), GP5(5), GP9(1), GYPA(3), HLA-DRA(6), IL11(2), IL11RA(2), IL1A(2), IL1B(2), IL1R1(4), IL1R2(5), IL2RA(2), IL3(1), IL3RA(5), IL4(1), IL4R(1), IL5RA(4), IL6R(1), IL7(1), IL7R(6), IL9R(3), ITGA1(7), ITGA2(5), ITGA2B(7), ITGA3(7), ITGA4(9), ITGA5(4), ITGA6(4), ITGAM(6), ITGB3(3), KIT(12), KITLG(2), MME(5), MS4A1(1), TFRC(1), THPO(4), TNF(1), TPO(15) 26757339 308 105 298 123 91 77 17 84 37 2 0.612 1.000 1.000 244 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 56 APC(35), AXIN1(8), CCND1(1), CCND2(3), CCND3(2), CSNK1E(7), DVL1(5), DVL2(3), DVL3(8), FBXW2(3), FZD1(7), FZD10(14), FZD2(7), FZD3(5), FZD5(3), FZD6(5), FZD7(4), FZD8(6), FZD9(2), GSK3B(4), JUN(3), LDLR(7), MAPK10(5), MAPK9(4), MYC(3), PAFAH1B1(5), PLAU(2), PPP2R5C(6), PPP2R5E(4), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCI(4), PRKCQ(7), PRKD1(16), SFRP4(3), TCF7(3), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6) 18993801 293 105 287 106 108 62 14 59 46 4 0.140 1.000 1.000 245 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(30), CCNA1(7), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CCNH(2), CDC25A(3), CDK2(3), CDKN1A(1), CDKN2A(8), CDKN2D(3), CREB3(4), CREB3L1(3), CREB3L3(3), CREB3L4(1), E2F1(2), E2F2(3), E2F3(2), E2F4(1), E2F5(1), E2F6(2), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), MDM2(3), MNAT1(2), MYC(3), MYT1(14), NACA(2), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(3), POLE(17), POLE2(3), PRIM1(2), RB1(6), RBL1(7), RPA1(1), RPA2(1), RPA3(2), TFDP1(3), TFDP2(3), TNXB(38), WEE1(2) 25052377 263 104 258 95 95 72 13 53 28 2 0.228 1.000 1.000 246 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(2), BMP4(4), BMP5(9), BMP6(7), BMP7(5), BMP8A(1), BMP8B(2), BTRC(5), CSNK1A1(3), CSNK1A1L(2), CSNK1D(2), CSNK1E(7), CSNK1G1(2), CSNK1G2(4), CSNK1G3(5), DHH(2), FBXW11(10), GLI1(7), GLI2(11), GLI3(33), GSK3B(4), HHIP(7), IHH(4), LRP2(51), PRKACA(3), PRKACB(2), PRKACG(5), PRKX(4), PTCH1(15), PTCH2(6), RAB23(1), SHH(4), SMO(10), STK36(10), SUFU(5), WNT1(5), WNT10A(4), WNT10B(1), WNT11(2), WNT16(5), WNT2(4), WNT2B(7), WNT3(5), WNT3A(4), WNT4(1), WNT5A(4), WNT5B(3), WNT6(2), WNT7A(3), WNT7B(6), WNT8A(1), WNT8B(1), WNT9A(3), WNT9B(3), ZIC2(2) 19822309 320 104 316 99 125 79 13 73 30 0 0.0109 1.000 1.000 247 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(9), CPEB1(3), EGFR(11), ERBB2(12), ERBB4(33), ETS1(5), ETS2(3), ETV6(3), ETV7(4), FMN2(24), GRB2(4), MAP2K1(5), MAPK1(2), MAPK3(1), NOTCH1(20), NOTCH2(19), NOTCH3(16), NOTCH4(11), PIWIL1(5), PIWIL2(5), PIWIL3(2), PIWIL4(4), RAF1(7), SOS1(6), SOS2(11), SPIRE1(4), SPIRE2(2) 16951050 231 101 218 90 84 57 10 61 19 0 0.577 1.000 1.000 248 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(22), ACSL1(2), ACSL3(6), ACSL4(2), ACSL5(5), ACSL6(5), ADIPOQ(3), ADIPOR1(4), ADIPOR2(4), AGRP(1), AKT1(3), AKT2(6), AKT3(6), CAMKK1(5), CAMKK2(1), CD36(2), CPT1A(7), CPT1B(3), CPT1C(6), CPT2(5), G6PC2(1), IKBKB(7), IRS1(15), IRS2(4), IRS4(16), JAK1(6), JAK2(10), JAK3(9), LEPR(13), MAPK10(5), MAPK8(5), MAPK9(4), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NPY(1), PCK1(6), PCK2(7), POMC(6), PPARA(3), PPARGC1A(9), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(3), PRKAG3(2), PRKCQ(7), PTPN11(5), RELA(3), RXRA(3), RXRB(1), RXRG(5), SLC2A1(6), SLC2A4(4), SOCS3(3), STAT3(7), STK11(2), TNF(1), TNFRSF1A(3), TNFRSF1B(2), TRADD(2), TRAF2(2), TYK2(4) 27172795 321 101 319 121 117 74 9 82 39 0 0.374 1.000 1.000 249 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(3), CDC40(5), CLK2(8), CLK3(8), CLK4(2), COL2A1(13), CPSF1(13), CPSF2(3), CPSF3(3), CPSF4(1), CSTF1(7), CSTF2(5), CSTF2T(4), CSTF3(5), DDIT3(3), DDX1(5), DDX20(4), DHX15(7), DHX16(6), DHX38(9), DHX8(10), DHX9(4), DICER1(8), DNAJC8(4), GIPC1(2), LOC440563(7), NCBP1(5), NONO(2), NUDT21(1), NXF1(5), PABPN1(2), PAPOLA(3), PHF5A(1), POLR2A(15), PPM1G(4), PRPF18(1), PRPF3(5), PRPF4(3), PRPF4B(11), PRPF8(13), PSKH1(4), PTBP1(5), PTBP2(1), RBM17(1), RBM5(4), RNGTT(3), RNMT(4), SF3A1(2), SF3A2(2), SF3A3(3), SF3B1(6), SF3B2(8), SF3B4(3), SF4(3), SFRS12(4), SFRS14(7), SFRS16(5), SFRS4(4), SFRS5(5), SFRS6(6), SFRS7(2), SFRS8(11), SFRS9(1), SNRPA(7), SNRPA1(2), SNRPB(1), SNRPB2(1), SNRPD1(2), SNRPD2(3), SNRPD3(2), SNRPE(1), SNRPN(5), SPOP(2), SRPK1(3), SRPK2(7), SRRM1(6), SUPT5H(7), U2AF1(3), U2AF2(3), XRN2(13) 34754765 382 98 379 124 140 111 19 73 39 0 0.207 1.000 1.000 250 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), AK3(5), CAD(12), CANT1(3), CTPS(2), CTPS2(3), DCTD(1), DHODH(2), DPYD(12), DPYS(7), DUT(1), ENTPD1(5), ENTPD3(4), ENTPD4(7), ENTPD6(2), ENTPD8(6), NME6(2), NME7(1), NT5C(1), NT5C1A(4), NT5C1B(5), NT5C2(7), NT5C3(1), NUDT2(3), PNPT1(4), POLA1(5), POLA2(3), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), POLE3(1), POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3A(15), POLR3B(9), POLR3G(2), POLR3K(1), PRIM1(2), PRIM2(6), RFC5(1), RRM1(5), RRM2(3), RRM2B(4), TK1(1), TK2(2), TXNRD1(5), TXNRD2(2), TYMS(1), UCK1(5), UCK2(1), UMPS(3), UPB1(2), UPP2(4), UPRT(3) 26600100 273 97 268 97 98 74 13 60 28 0 0.197 1.000 1.000 251 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(3), AKT2(6), AKT3(6), BAD(3), CASP9(2), CDC42(1), KDR(8), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(4), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), NOS3(5), NRAS(2), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCG1(16), PLCG2(11), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKCA(3), PRKCG(13), PTGS2(5), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(7), SH2D2A(5), SHC2(2), SPHK1(4), SPHK2(2), SRC(2) 22701643 298 97 290 87 112 74 11 68 33 0 0.00564 1.000 1.000 252 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(5), ATM(30), ATR(13), BAI1(8), BAX(1), BID(2), CASP3(2), CASP8(8), CASP9(2), CCNB1(3), CCNB2(1), CCNB3(16), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNE2(2), CD82(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(8), CHEK1(4), CHEK2(7), DDB2(1), EI24(1), FAS(3), GTSE1(3), IGF1(4), IGFBP3(5), LRDD(6), MDM2(3), MDM4(4), PERP(3), PPM1D(7), RCHY1(1), RFWD2(5), RPRM(3), RRM2(3), RRM2B(4), SERPINB5(2), SERPINE1(3), SESN1(1), SESN2(2), SESN3(4), SIAH1(1), STEAP3(6), THBS1(12), TNFRSF10B(2), TP73(2), TSC2(7), ZMAT3(4) 20865295 234 96 232 79 71 67 7 56 31 2 0.256 1.000 1.000 253 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(1), BRAF(9), CREB1(3), DAXX(9), ELK1(3), FOS(1), GRB2(4), IKBKB(7), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K5(1), MAP2K6(1), MAP3K1(9), MAP3K10(8), MAP3K11(7), MAP3K12(9), MAP3K13(7), MAP3K14(3), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAP3K5(4), MAP3K6(5), MAP3K7(8), MAP3K9(3), MAP4K1(3), MAP4K2(4), MAP4K3(3), MAP4K4(8), MAP4K5(3), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(1), MAPK7(7), MAPK8(5), MAPK9(4), MAPKAPK2(1), MAPKAPK3(4), MAPKAPK5(1), MAX(3), MEF2A(1), MEF2B(4), MEF2C(3), MEF2D(6), MKNK1(3), MKNK2(1), MYC(3), NFKB1(7), NFKBIA(1), PAK1(5), PAK2(6), RAF1(7), RELA(3), RIPK1(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KA4(1), RPS6KA5(2), RPS6KB1(4), RPS6KB2(3), SHC1(3), SP1(6), STAT1(7), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TRADD(2), TRAF2(2) 30931102 329 96 321 125 112 88 16 60 53 0 0.484 1.000 1.000 254 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(2), AKT1(3), BDKRB2(3), CALM1(1), CALM2(3), CAV1(4), CHRM1(2), CHRNA1(4), FLT1(13), FLT4(17), KDR(8), NOS3(5), PDE2A(8), PDE3A(11), PDE3B(13), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKG1(8), PRKG2(10), RYR2(61), SLC7A1(4), SYT1(3), TNNI1(1) 13296629 206 96 206 79 64 59 7 63 13 0 0.375 1.000 1.000 255 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR2(2), ACTR3(2), AKT1(3), AKT2(6), AKT3(6), ANGPTL2(3), ARHGAP1(1), ARHGAP4(4), ARHGEF11(12), BTK(2), CDC42(1), CFL1(1), GDI1(2), GDI2(3), INPPL1(14), ITPR1(21), ITPR2(21), ITPR3(31), LIMK1(3), MYLK(15), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PDK1(2), PIK3CD(10), PIK3CG(15), PIK3R1(8), PITX2(4), PPP1R13B(6), RACGAP1(5), RHO(6), ROCK1(9), ROCK2(7), SAG(2), WASF1(3), WASL(2) 22063068 267 96 260 88 105 68 12 49 31 2 0.0988 1.000 1.000 256 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 78 AIFM1(2), AKT1(3), AKT2(6), AKT3(6), APAF1(5), ATM(30), BAD(3), BAX(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CAPN1(2), CAPN2(3), CASP10(5), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), CSF2RB(7), DFFA(4), DFFB(3), FAS(3), FASLG(2), IKBKB(7), IL1A(2), IL1B(2), IL1R1(4), IL1RAP(5), IL3(1), IL3RA(5), IRAK1(6), IRAK2(8), IRAK3(4), IRAK4(2), MAP3K14(3), MYD88(1), NFKB1(7), NFKB2(2), NFKBIA(1), NTRK1(6), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PRKACA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RELA(3), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(3), TNFRSF1A(3), TNFSF10(3), TRADD(2), TRAF2(2) 26372946 299 95 291 93 106 71 9 67 44 2 0.0618 1.000 1.000 257 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ADAM17(5), ATP6AP1(5), ATP6V0A1(5), ATP6V0A2(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), CASP3(2), CCL5(1), CDC42(1), CSK(5), EGFR(11), F11R(2), GIT1(3), HBEGF(2), IGSF5(2), IKBKB(7), IL8(1), JAM2(2), JAM3(4), JUN(3), LYN(4), MAP2K4(7), MAP3K14(3), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK8(5), MAPK9(4), MET(7), NFKB1(7), NFKB2(2), NFKBIA(1), NOD1(8), PAK1(5), PLCG1(16), PLCG2(11), PTPN11(5), PTPRZ1(20), RELA(3), SRC(2), TCIRG1(6), TJP1(11) 23054693 255 94 250 97 74 74 8 68 31 0 0.499 1.000 1.000 258 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(9), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), AOX1(7), CARM1(4), COMT(4), DBH(5), DCT(8), DDC(5), ESCO1(4), ESCO2(4), FAH(3), GOT1(2), GOT2(2), GSTZ1(3), HEMK1(1), HGD(3), HPD(1), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(2), MIF(1), MYST3(20), MYST4(15), NAT6(2), PNMT(8), PNPLA3(1), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), SH3GLB1(1), TAT(4), TH(2), TPO(15), TYR(6), TYRP1(3), WBSCR22(4) 19503124 231 93 228 69 76 66 6 61 21 1 0.0185 1.000 1.000 259 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(3), ADCY4(5), ADCY6(10), ADCY8(21), CACNA1A(16), CACNA1B(22), GNAS(20), GNAT3(4), GNG13(2), GRM4(6), ITPR3(31), KCNB1(8), PDE1A(6), PLCB2(4), PRKACA(3), PRKACB(2), PRKACG(5), PRKX(4), SCNN1A(1), SCNN1B(7), SCNN1G(3), TAS1R1(6), TAS1R2(5), TAS1R3(7), TAS2R1(3), TAS2R13(3), TAS2R14(1), TAS2R16(5), TAS2R3(2), TAS2R38(5), TAS2R39(1), TAS2R4(4), TAS2R40(3), TAS2R41(3), TAS2R43(3), TAS2R5(3), TAS2R50(1), TAS2R60(3), TAS2R7(3), TAS2R8(1), TAS2R9(1), TRPM5(4) 18620215 250 92 246 98 96 72 10 57 15 0 0.385 1.000 1.000 260 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(2), AGT(3), AKT1(3), CALM1(1), CALM2(3), CALR(3), CAMK1(2), CAMK1G(3), CAMK4(6), CREBBP(27), CSNK1A1(3), EDN1(2), ELSPBP1(1), F2(5), FGF2(2), FKBP1A(2), GATA4(4), GSK3B(4), HAND1(2), HAND2(2), IGF1(4), LIF(1), MAP2K1(5), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(5), MEF2C(3), MYH2(23), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), NKX2-5(3), NPPA(1), PIK3R1(8), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RAF1(7), RPS6KB1(4), SYT1(3) 15905471 229 91 226 76 85 59 8 45 32 0 0.0616 1.000 1.000 261 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(3), AKT2(6), AKT3(6), BAD(3), BCL2(2), BCR(10), BLNK(3), BTK(2), CD19(3), CD22(3), CD81(3), CR2(8), CSK(5), DAG1(8), FLOT1(2), FLOT2(3), GRB2(4), GSK3A(2), GSK3B(4), INPP5D(1), ITPR1(21), ITPR2(21), ITPR3(31), LYN(4), MAP4K1(3), MAPK1(2), MAPK3(1), NFATC1(11), NFATC2(14), NR0B2(2), PDK1(2), PIK3CD(10), PIK3R1(8), PLCG2(11), PPP1R13B(6), PPP3CA(5), PPP3CB(6), PPP3CC(3), PTPRC(15), RAF1(7), SHC1(3), SOS1(6), SOS2(11), SYK(6), VAV1(6) 23590738 296 91 290 100 113 71 7 70 34 1 0.103 1.000 1.000 262 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(6), AKT3(6), ASAH1(2), BRAF(9), DAG1(8), DRD2(7), EGFR(11), EPHB2(8), GRB2(4), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(21), ITPR3(31), KCNJ3(9), KCNJ5(3), MAPK1(2), PI3(1), PIK3CB(7), PITX2(4), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), RAF1(7), RGS20(4), SHC1(3), SOS1(6), SOS2(11), SRC(2), STAT3(7), TERF2IP(4) 19212115 249 91 244 96 99 64 7 61 17 1 0.467 1.000 1.000 263 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 48 ABL1(4), ACTB(7), ARHGEF2(10), CD14(2), CDC42(1), CLDN1(2), CTTN(5), EZR(3), FYN(8), HCLS1(3), ITGB1(6), KRT18(2), LY96(1), NCK1(6), NCK2(3), NCL(6), OCLN(4), PRKCA(3), ROCK1(9), ROCK2(7), TLR4(18), TLR5(8), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(5), TUBA3D(4), TUBA3E(9), TUBA4A(1), TUBA8(4), TUBAL3(4), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB3(12), TUBB4(4), TUBB4Q(4), TUBB6(7), TUBB8(3), WAS(1), WASL(2), YWHAQ(2), YWHAZ(2) 16031152 195 90 189 71 67 58 5 49 15 1 0.242 1.000 1.000 264 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 48 ABL1(4), ACTB(7), ARHGEF2(10), CD14(2), CDC42(1), CLDN1(2), CTTN(5), EZR(3), FYN(8), HCLS1(3), ITGB1(6), KRT18(2), LY96(1), NCK1(6), NCK2(3), NCL(6), OCLN(4), PRKCA(3), ROCK1(9), ROCK2(7), TLR4(18), TLR5(8), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(5), TUBA3D(4), TUBA3E(9), TUBA4A(1), TUBA8(4), TUBAL3(4), TUBB1(3), TUBB2A(2), TUBB2B(1), TUBB2C(3), TUBB3(12), TUBB4(4), TUBB4Q(4), TUBB6(7), TUBB8(3), WAS(1), WASL(2), YWHAQ(2), YWHAZ(2) 16031152 195 90 189 71 67 58 5 49 15 1 0.242 1.000 1.000 265 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(3), AKT2(6), AKT3(6), BCR(10), BTK(2), CD19(3), CDKN2A(8), DAPP1(1), FLOT1(2), FLOT2(3), GAB1(2), ITPR1(21), ITPR2(21), ITPR3(31), LYN(4), NR0B2(2), PDK1(2), PHF11(4), PITX2(4), PLCG2(11), PPP1R13B(6), PREX1(13), PTPRC(15), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SAG(2), SYK(6), TEC(4), VAV1(6) 17162294 219 90 216 84 84 51 5 53 25 1 0.540 1.000 1.000 266 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(3), APC(35), AR(14), ASAH1(2), BRAF(9), CAMP(2), CCL15(2), CCL16(1), DAG1(8), EGFR(11), GNA11(5), GNA15(3), GNAI1(1), GNAQ(3), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(21), ITPR3(31), KCNJ3(9), KCNJ5(3), MAPK1(2), MAPK10(5), MAPK14(1), PHKA2(9), PIK3CD(10), PIK3R1(8), PITX2(4), PTX3(2), RAF1(7), SRC(2) 16790187 242 89 232 82 90 55 11 53 30 3 0.132 1.000 1.000 267 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(9), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPAT6(3), CDIPT(1), CDS1(4), CDS2(2), CHAT(4), CHKA(1), CHKB(2), CHPT1(3), CRLS1(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKI(9), DGKZ(4), ESCO1(4), ESCO2(4), ETNK1(1), ETNK2(1), GNPAT(1), GPAM(7), GPD1(6), GPD1L(3), GPD2(6), LCAT(4), MYST3(20), MYST4(15), NAT6(2), PCYT1A(6), PCYT1B(5), PEMT(1), PISD(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLD1(13), PLD2(13), PNPLA3(1), PPAP2A(1), PPAP2C(4), PTDSS1(3), PTDSS2(2), SH3GLB1(1) 21395653 243 88 242 88 82 76 9 55 20 1 0.185 1.000 1.000 268 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(3), AKT2(6), AKT3(6), BCL10(1), BLNK(3), BTK(2), CARD11(15), CD19(3), CD22(3), CD72(1), CD79A(6), CD79B(1), CD81(3), CR2(8), FCGR2B(3), FOS(1), GSK3B(4), IFITM1(3), IKBKB(7), INPP5D(1), JUN(3), LILRB3(3), LYN(4), MALT1(4), NFAT5(9), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NRAS(2), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLCG2(11), PPP3CA(5), PPP3CB(6), PPP3CC(3), PPP3R2(3), PTPN6(3), RAC2(2), RAC3(3), RASGRP3(4), SYK(6), VAV1(6), VAV2(11), VAV3(10) 23571755 294 88 290 103 109 81 7 62 35 0 0.113 1.000 1.000 269 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(3), AKT2(6), AKT3(6), BRD4(9), CAP1(3), CBL(2), CDC42(1), CDKN2A(8), F2RL2(2), FLOT1(2), FLOT2(3), GRB2(4), GSK3A(2), GSK3B(4), IGFBP1(5), INPPL1(14), IRS1(15), IRS2(4), IRS4(16), LNPEP(8), MAPK1(2), MAPK3(1), PARD3(9), PARD6A(1), PDK1(2), PIK3CD(10), PIK3R1(8), PPYR1(6), PTPN1(2), RAF1(7), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SERPINB6(3), SHC1(3), SLC2A4(4), SORBS1(7), SOS1(6), SOS2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2) 18523139 230 88 226 78 94 58 3 41 34 0 0.173 1.000 1.000 270 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(7), AKT1(3), APC(35), ASAH1(2), CAMP(2), CAV3(2), DAG1(8), DLG4(3), EPHB2(8), GNAI1(1), GNAQ(3), ITPR1(21), ITPR2(21), ITPR3(31), KCNJ3(9), KCNJ5(3), MAPK1(2), PITX2(4), PTX3(2), RHO(6), RYR1(43) 15057186 216 88 211 79 89 45 7 45 27 3 0.233 1.000 1.000 271 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(3), AKT2(6), AKT3(6), ANKRD6(3), APC(35), AXIN1(8), AXIN2(4), CER1(2), CSNK1A1(3), DACT1(8), DKK1(7), DKK2(4), DKK3(2), DKK4(1), DVL1(5), FSTL1(2), GSK3A(2), GSK3B(4), LRP1(26), MVP(5), NKD1(5), NKD2(1), PIN1(1), PSEN1(2), PTPRA(7), SENP2(2), SFRP1(4), TSHB(2), WIF1(2) 12681324 162 88 157 60 55 39 2 38 25 3 0.568 1.000 1.000 272 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 71 AKT1(3), AKT2(6), AKT3(6), BTK(2), FCER1A(2), FYN(8), GRB2(4), IL13(1), IL3(1), IL4(1), INPP5D(1), LAT(2), LCP2(5), LYN(4), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), MAPK9(4), MS4A2(1), NRAS(2), PDK1(2), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCG1(16), PLCG2(11), PRKCA(3), PRKCD(7), PRKCE(8), RAC2(2), RAC3(3), RAF1(7), SOS1(6), SOS2(11), SYK(6), TNF(1), VAV1(6), VAV2(11), VAV3(10) 22554606 289 87 282 92 99 81 8 68 33 0 0.0669 1.000 1.000 273 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 64 AGTR1(1), AGTR2(2), ATP8A1(7), AVPR1A(8), AVPR1B(2), AVPR2(4), BDKRB1(1), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(4), CCKBR(6), CCR1(2), CCR10(2), CCR2(5), CCR3(6), CCR5(3), CCR6(1), CCR7(2), CCR8(1), CX3CR1(3), CXCR4(1), CXCR6(2), EDNRA(3), FPR1(4), GALR1(5), GALR2(9), GALR3(1), GALT(1), GHSR(8), GNB2L1(4), GNRHR(4), GPR77(1), GRPR(7), LHCGR(10), MC2R(2), MC3R(3), MC4R(5), MC5R(5), NMBR(3), NPY1R(3), NPY2R(3), NPY5R(3), NTSR1(5), NTSR2(3), OPRD1(1), OPRK1(6), OPRL1(6), OPRM1(3), OXTR(5), PPYR1(6), SSTR1(9), SSTR2(3), SSTR3(5), SSTR4(11), TACR1(3), TACR2(1), TACR3(11), TRHR(4), TSHR(8) 16399395 248 87 243 100 99 77 8 47 17 0 0.156 1.000 1.000 274 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(2), ACTN1(6), ACTN2(22), ACTN3(2), BCAR1(4), BCR(10), CAPN1(2), CAPNS1(2), CAPNS2(2), CAV1(4), CRKL(1), CSK(5), FYN(8), GRB2(4), ITGA1(7), ITGB1(6), JUN(3), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MAPK8(5), PPP1R12B(12), PTK2(10), PXN(3), RAF1(7), RAP1A(2), ROCK1(9), SHC1(3), SOS1(6), SRC(2), TLN1(14), VCL(1), ZYX(5) 15422014 179 86 174 68 64 45 9 47 13 1 0.433 1.000 1.000 275 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(7), AR(14), ESR1(7), ESR2(8), HNF4A(8), NR0B1(2), NR1D1(4), NR1D2(5), NR1H2(6), NR1H3(4), NR1I2(6), NR1I3(3), NR2C2(2), NR2E1(2), NR2F1(3), NR2F2(3), NR2F6(3), NR3C1(5), NR4A1(4), NR4A2(9), NR5A1(5), NR5A2(1), PGR(12), PPARA(3), PPARD(7), PPARG(1), RARA(2), RARB(6), ROR1(6), RORA(5), RORC(4), RXRA(3), RXRB(1), RXRG(5), THRA(4), THRB(7), VDR(3) 13747936 180 86 177 79 71 38 13 46 12 0 0.784 1.000 1.000 276 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(4), APOA1(5), CD36(2), CITED2(3), CPT1B(3), CREBBP(27), DUSP1(2), DUT(1), EHHADH(6), EP300(19), HSD17B4(4), HSPA1A(1), JUN(3), LPL(4), MAPK1(2), MAPK3(1), ME1(1), MYC(3), NCOA1(12), NCOR1(24), NCOR2(21), NFKBIA(1), NR0B2(2), NR1H3(4), NR2F1(3), NRIP1(11), PDGFA(2), PIK3R1(8), PPARA(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), PTGS2(5), RB1(6), RELA(3), RXRA(3), SP1(6), SRA1(2), STAT5A(4), STAT5B(6), TNF(1) 20001670 243 86 241 81 69 74 8 58 33 1 0.0980 1.000 1.000 277 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(2), IMPA1(3), IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(5), INPP5B(7), INPP5E(6), INPPL1(14), IPMK(1), ISYNA1(2), ITGB1BP3(2), ITPK1(4), ITPKA(1), ITPKB(7), MINPP1(4), MIOX(3), OCRL(8), PI4KA(11), PI4KB(3), PIK3C3(10), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIP4K2A(4), PIP4K2B(2), PIP4K2C(1), PIP5K1A(3), PIP5K1B(1), PIP5K1C(8), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCD3(8), PLCD4(2), PLCE1(11), PLCG1(16), PLCG2(11), PLCZ1(3), PTPMT1(1), SYNJ1(7), SYNJ2(9) 23369459 259 85 250 86 102 76 4 54 23 0 0.0601 1.000 1.000 278 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(5), CAD(12), CANT1(3), CTPS(2), CTPS2(3), DCTD(1), DHODH(2), DPYD(12), DPYS(7), DUT(1), ENTPD1(5), NT5C(1), NUDT2(3), POLB(2), POLD1(10), POLD2(1), POLE(17), POLG(5), POLL(2), POLQ(22), POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLRMT(10), RRM1(5), RRM2(3), TK1(1), TK2(2), TXNRD1(5), TYMS(1), UCK1(5), UCK2(1), UMPS(3), UNG(1), UPB1(2) 18781247 191 85 188 74 58 53 11 49 20 0 0.514 1.000 1.000 279 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 BAK1(3), BAX(1), BFAR(2), BTK(2), CAD(12), CASP10(5), CASP3(2), CASP8(8), CASP8AP2(7), CD7(3), CSNK1A1(3), DAXX(9), DEDD(2), DEDD2(1), DFFA(4), DIABLO(1), EGFR(11), EPHB2(8), FAF1(8), FAIM2(1), IL1A(2), IL8(1), MAP2K4(7), MAP3K1(9), MAP3K5(4), MAPK1(2), MAPK10(5), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MET(7), NFAT5(9), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), NR0B2(2), PFN2(2), PTPN13(16), RALBP1(5), RIPK1(1), ROCK1(9), SMPD1(5), TPX2(6), TRAF2(2), TUFM(3) 23374031 238 85 235 95 79 65 7 55 31 1 0.585 1.000 1.000 280 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(2), CSK(5), CTLA4(3), DAG1(8), EPHB2(8), GRAP2(4), GRB2(4), ITK(5), ITPKA(1), ITPKB(7), LAT(2), LCK(3), LCP2(5), MAPK1(2), NCK1(6), NFAT5(9), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PLCG1(16), PTPRC(15), RAF1(7), RASGRP1(5), RASGRP2(6), RASGRP3(4), RASGRP4(3), SOS1(6), SOS2(11), VAV1(6), ZAP70(10) 17762791 220 85 215 79 75 59 9 55 22 0 0.382 1.000 1.000 281 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AGK(5), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPAT6(3), AKR1A1(1), AKR1B1(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CEL(7), DAK(5), DGAT1(1), DGAT2(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKI(9), DGKZ(4), GK(3), GK2(3), GLB1(2), GPAM(7), LCT(15), LIPA(1), LIPC(2), LIPF(2), LIPG(2), LPL(4), MGLL(1), PNLIP(4), PNLIPRP1(3), PNLIPRP2(5), PNPLA3(1), PPAP2A(1), PPAP2C(4) 19253651 199 83 198 84 57 69 5 47 20 1 0.567 1.000 1.000 282 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 APAF1(5), ARHGDIB(1), BAG4(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP2(3), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), CRADD(1), DAXX(9), DFFA(4), DFFB(3), GSN(9), LMNA(4), LMNB1(1), LMNB2(4), MAP3K1(9), MAP3K14(3), MAP3K5(4), MAPK8(5), MDM2(3), NFKB1(7), NFKBIA(1), NUMA1(18), PAK2(6), PRKCD(7), PRKDC(32), PSEN1(2), PSEN2(2), PTK2(10), RASA1(11), RB1(6), RELA(3), RIPK1(1), SPTAN1(18), TNF(1), TNFRSF1A(3), TNFRSF1B(2), TRADD(2), TRAF1(3), TRAF2(2) 22473626 231 82 226 79 71 66 12 47 35 0 0.245 1.000 1.000 283 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), ASCC3(24), ATP13A2(10), DDX18(8), DDX19A(4), DDX23(7), DDX4(4), DDX41(7), DDX47(2), DDX50(6), DDX51(2), DDX52(1), DDX54(13), DDX55(3), DDX56(4), DHX58(7), ENTPD7(9), EP400(25), ERCC2(5), ERCC3(7), FPGS(1), GGH(3), IFIH1(5), MOV10L1(3), NUDT5(1), QDPR(1), RAD54B(3), RAD54L(4), RUVBL2(2), SETX(12), SKIV2L2(7), SMARCA2(16), SMARCA5(3), SPR(2) 20604849 234 82 233 94 92 62 8 51 21 0 0.612 1.000 1.000 284 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 ACVR1(5), APC(35), ATF2(1), AXIN1(8), BMP10(4), BMP2(2), BMP4(4), BMP5(9), BMP7(5), BMPR1A(3), BMPR2(11), CHRD(6), DVL1(5), FZD1(7), GATA4(4), GSK3B(4), MAP3K7(8), MEF2C(3), MYL2(6), NKX2-5(3), NPPA(1), NPPB(2), RFC1(5), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TGFBR2(11), TGFBR3(4), WNT1(5) 11383310 180 81 175 66 50 41 8 38 38 5 0.591 1.000 1.000 285 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(2), ACADM(4), ACOX1(4), ACOX2(6), ACOX3(8), ACSL1(2), ACSL3(6), ACSL4(2), ACSL5(5), ACSL6(5), ADIPOQ(3), ANGPTL4(2), APOA1(5), APOA5(5), AQP7(3), CD36(2), CPT1A(7), CPT1B(3), CPT1C(6), CPT2(5), CYP27A1(4), CYP4A11(2), CYP4A22(2), CYP7A1(4), CYP8B1(5), EHHADH(6), FABP2(1), FABP3(1), FABP5(1), FABP6(3), FABP7(1), FADS2(4), GK(3), GK2(3), HMGCS2(3), ILK(3), LPL(4), ME1(1), MMP1(3), NR1H3(4), OLR1(2), PCK1(6), PCK2(7), PDPK1(2), PLTP(2), PPARA(3), PPARD(7), PPARG(1), RXRA(3), RXRB(1), RXRG(5), SCD(1), SCP2(4), SLC27A1(3), SLC27A2(4), SLC27A4(6), SLC27A5(4), SLC27A6(7), SORBS1(7), UBC(5), UCP1(1) 21504904 224 81 221 82 85 44 16 60 19 0 0.346 1.000 1.000 286 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM1(1), CALM2(3), CD3E(2), ELK1(3), FOS(1), FYN(8), GRB2(4), JUN(3), LAT(2), LCK(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), NFKB1(7), NFKBIA(1), PIK3R1(8), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), PTPN7(3), RAF1(7), RASA1(11), RELA(3), SHC1(3), SOS1(6), SYT1(3), VAV1(6), ZAP70(10) 14970604 200 81 193 50 68 56 4 38 34 0 0.00277 1.000 1.000 287 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(5), AASS(6), ACAT1(3), ACAT2(3), AKR1B10(2), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BBOX1(3), DLST(4), DOT1L(8), EHHADH(6), EHMT1(10), EHMT2(6), GCDH(5), HADH(3), HADHA(4), HSD17B4(4), HSD3B7(4), NSD1(17), OGDH(7), OGDHL(10), PIPOX(3), PLOD1(7), PLOD2(6), PLOD3(8), RDH11(1), RDH12(1), RDH13(3), SETD1A(9), SETD7(1), SETDB1(13), SHMT1(1), SHMT2(5), SPCS1(1), SPCS3(2), SUV39H1(5), SUV39H2(2), TMLHE(5) 19021800 211 80 208 68 71 62 7 43 28 0 0.0829 1.000 1.000 288 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(5), APH1A(1), CREBBP(27), CTBP1(3), CTBP2(5), DLL1(10), DLL3(5), DLL4(3), DTX1(11), DTX2(4), DTX3(1), DTX3L(1), DTX4(6), DVL1(5), DVL2(3), DVL3(8), EP300(19), HDAC1(3), HDAC2(2), JAG1(10), JAG2(4), MAML1(5), MAML2(6), MAML3(8), NCOR2(21), NCSTN(4), NOTCH1(20), NOTCH2(19), NOTCH3(16), NOTCH4(11), NUMB(2), NUMBL(3), PSEN1(2), PSEN2(2), PSENEN(2), PTCRA(1), RBPJ(5), RBPJL(2), RFNG(2), SNW1(3) 22550659 270 80 266 123 106 65 14 53 32 0 0.773 1.000 1.000 289 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(7), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(3), CDC42(1), CFL1(1), FLNA(16), FLNC(22), FSCN1(5), FSCN3(11), GDI1(2), GDI2(3), LIMK1(3), MYH2(23), MYLK(15), MYLK2(2), PAK1(5), PAK2(6), PAK3(4), PAK4(6), PAK6(5), PAK7(7), PFN2(2), RHO(6), ROCK1(9), ROCK2(7), VASP(2), WASF1(3), WASL(2) 15700591 185 80 184 66 75 49 6 37 17 1 0.173 1.000 1.000 290 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(12), GABBR1(8), GPRC5B(8), GPRC5C(3), GPRC5D(2), GRM1(26), GRM2(19), GRM3(12), GRM4(6), GRM5(23), GRM7(15), GRM8(15) 6883262 149 79 141 55 67 26 7 39 10 0 0.225 1.000 1.000 291 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(18), COL4A2(10), COL4A3(8), COL4A4(10), COL4A5(9), COL4A6(6), F10(6), F11(3), F12(2), F2(5), F2R(2), F5(13), F8(15), F9(6), FGA(7), FGB(2), FGG(2), KLKB1(7), PROC(2), PROS1(8), SERPINC1(4), SERPING1(5) 14598158 150 79 150 56 40 45 7 48 10 0 0.298 1.000 1.000 292 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(3), APC(35), AXIN1(8), CCND1(1), CD14(2), DVL1(5), FZD1(7), GJA1(9), GNAI1(1), GSK3B(4), IRAK1(6), LBP(1), LEF1(5), LY96(1), MYD88(1), NFKB1(7), PDPK1(2), PIK3R1(8), PPP2CA(3), RELA(3), TIRAP(1), TLR4(18), TOLLIP(2), WNT1(5) 8807502 138 78 132 38 33 32 5 35 30 3 0.0675 1.000 1.000 293 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(4), ABO(1), B3GALNT1(2), B3GALT1(3), B3GALT2(6), B3GALT4(4), B3GALT5(1), B3GNT1(3), B3GNT2(2), B3GNT3(5), B3GNT4(4), B3GNT5(3), B4GALNT1(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), B4GALT6(2), FUT1(2), FUT3(1), FUT4(1), FUT5(2), FUT6(2), FUT7(2), FUT9(5), GBGT1(1), GCNT2(1), PIGA(2), PIGB(5), PIGC(3), PIGG(8), PIGK(3), PIGL(2), PIGM(5), PIGN(5), PIGO(4), PIGP(1), PIGQ(2), PIGS(3), PIGT(2), PIGU(1), PIGV(4), PIGX(2), PIGZ(2), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4), ST3GAL5(2), ST3GAL6(3), ST6GALNAC3(5), ST6GALNAC5(1), ST6GALNAC6(2), ST8SIA1(4), ST8SIA5(4), UGCG(3) 15889413 164 78 161 76 67 40 4 39 13 1 0.871 1.000 1.000 294 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(2), DAXX(9), EGF(8), EGFR(11), ETS1(5), ETS2(3), FOS(1), HOXA7(2), IKBKB(7), JUN(3), MAP2K1(5), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K14(3), MAP3K5(4), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), NFKB1(7), NFKBIA(1), PPP2CA(3), PRKCA(3), PRKCD(7), PRKCE(8), PRKCG(13), PRKCH(6), PRKCQ(7), RAF1(7), RELA(3), RIPK1(1), SP1(6), TNF(1), TNFRSF1A(3), TNFRSF1B(2), TRAF2(2) 15879375 177 78 171 68 62 47 5 36 27 0 0.373 1.000 1.000 295 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(3), ASAH1(2), BRAF(9), CAMP(2), CREB1(3), CREB3(4), CREB5(4), CREBBP(27), CRKL(1), DAG1(8), EGR1(4), EGR2(6), EGR3(5), EGR4(4), ELK1(3), FRS2(3), GNAQ(3), JUN(3), MAP1B(12), MAP2K4(7), MAPK1(2), MAPK10(5), MAPK3(1), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), NTRK1(6), OPN1LW(6), PIK3C2G(7), PIK3CD(10), PIK3R1(8), PTPN11(5), RPS6KA3(3), SHC1(3), SRC(2), TERF2IP(4), TH(2) 15847083 201 78 199 77 73 58 3 39 28 0 0.284 1.000 1.000 296 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 40 AGL(13), AMY2A(3), ENPP1(5), ENPP3(4), GAA(2), GANAB(4), GBA3(1), GBE1(3), GCK(4), GPI(5), GUSB(8), GYS1(3), GYS2(4), HK1(11), HK2(9), HK3(5), MGAM(9), PGM1(2), PGM3(10), PYGB(8), PYGL(6), PYGM(9), RNPC3(1), SI(19), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3), UXS1(3) 18327464 184 78 184 69 53 58 4 47 22 0 0.400 1.000 1.000 297 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(14), CARM1(4), CCND1(1), CREBBP(27), EP300(19), ERCC3(7), ESR1(7), GRIP1(12), GTF2A1(2), GTF2E1(4), GTF2F1(5), HDAC1(3), HDAC2(2), HDAC3(4), HDAC4(13), HDAC5(6), HDAC6(7), MEF2C(3), NCOR2(21), NR0B1(2), NRIP1(11), PELP1(5), POLR2A(15), SRA1(2), TBP(2) 15055680 198 77 193 66 71 61 7 36 23 0 0.0688 1.000 1.000 298 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(2), CRK(1), CRKL(1), DOCK1(15), ELK1(3), FOS(1), GAB1(2), GRB2(4), HGF(13), ITGA1(7), ITGB1(6), JUN(3), MAP2K1(5), MAP2K2(2), MAP4K1(3), MAPK1(2), MAPK3(1), MAPK8(5), MET(7), PAK1(5), PIK3R1(8), PTK2(10), PTK2B(10), PTPN11(5), PXN(3), RAF1(7), RAP1A(2), RAP1B(5), RASA1(11), SOS1(6), SRC(2), STAT3(7) 13527236 164 77 157 54 46 41 9 43 25 0 0.218 1.000 1.000 299 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(3), AKT2(6), AKT3(6), BAD(3), BCR(10), BLNK(3), BTK(2), CD19(3), CSK(5), DAG1(8), EPHB2(8), GRB2(4), ITPKA(1), ITPKB(7), LYN(4), MAP2K1(5), MAP2K2(2), MAPK1(2), NFAT5(9), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PI3(1), PIK3CD(10), PIK3R1(8), PLCG2(11), PPP1R13B(6), RAF1(7), SERPINA4(2), SHC1(3), SOS1(6), SOS2(11), SYK(6), VAV1(6) 16569310 192 77 189 72 68 50 4 49 21 0 0.423 1.000 1.000 300 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(3), DAG1(8), DGKA(4), ETFA(1), GCA(2), ITGA9(7), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(21), ITPR3(31), MAP2K1(5), MAPK1(2), MAPK3(1), NR1I3(3), PAK1(5), PDE3A(11), PDE3B(13), PI3(1), PIK3C2G(7), PIK3CD(10), PIK3R1(8), PLDN(1), PSME1(2), RIPK3(4), SGCB(3), VASP(2) 15267121 191 77 188 63 70 49 8 42 21 1 0.0938 1.000 1.000 301 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(5), BAD(3), BAX(1), BCL2(2), BCL2L2(1), BOK(1), CASP1(2), CASP10(5), CASP2(3), CASP3(2), CASP4(4), CASP6(1), CASP7(2), CASP8(8), CASP9(2), CD40(1), CD40LG(4), CRADD(1), DAXX(9), DFFA(4), DFFB(3), FAS(3), FASLG(2), IKBKE(8), LTA(3), MCL1(1), NFKB1(7), NFKBIA(1), NGFR(4), NR3C1(5), NTRK1(6), PTPN13(16), RIPK1(1), SFRS2IP(12), TFG(1), TNF(1), TNFRSF1A(3), TNFRSF1B(2), TRADD(2), TRAF1(3), TRAF2(2), TRAF3(3), TRAF6(5) 14249159 155 76 152 57 39 37 13 45 21 0 0.498 1.000 1.000 302 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AKR1A1(1), AKR1B1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CEL(7), DGAT1(1), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKZ(4), GK(3), GLB1(2), LCT(15), LIPC(2), LIPF(2), LIPG(2), LPL(4), PNLIP(4), PNLIPRP1(3), PNLIPRP2(5), PPAP2A(1), PPAP2C(4) 15816961 168 76 167 80 49 55 4 42 17 1 0.860 1.000 1.000 303 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(3), AKT2(6), AKT3(6), BRAF(9), CAB39(1), EIF4B(4), EIF4EBP1(2), HIF1A(5), IGF1(4), MAPK1(2), MAPK3(1), PDPK1(2), PGF(1), PIK3CB(7), PIK3CD(10), PIK3CG(15), PIK3R1(8), PIK3R2(8), PIK3R3(4), PIK3R5(7), PRKAA1(4), PRKAA2(5), RHEB(1), RICTOR(13), RPS6(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), RPS6KB2(3), STK11(2), TSC1(3), TSC2(7), ULK1(12), ULK2(5), VEGFC(8) 16228568 190 76 186 64 85 44 7 37 17 0 0.167 1.000 1.000 304 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(35), AXIN1(8), CREBBP(27), DVL1(5), EP300(19), FZD1(7), GSK3B(4), HDAC1(3), LDB1(4), LEF1(5), PITX2(4), TRRAP(37), WNT1(5) 10333141 163 76 156 52 64 33 4 28 31 3 0.122 1.000 1.000 305 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(35), AXIN1(8), BTRC(5), CCND1(1), CREBBP(27), CSNK1A1(3), CSNK1D(2), CSNK2A1(8), CTBP1(3), DVL1(5), FZD1(7), GSK3B(4), HDAC1(3), MAP3K7(8), MYC(3), NLK(6), PPARD(7), PPP2CA(3), TLE1(5), WIF1(2), WNT1(5) 9067681 150 76 143 44 50 33 7 23 34 3 0.0803 1.000 1.000 306 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 64 APAF1(5), BAD(3), BAK1(3), BAX(1), BCL2(2), BCL2L11(1), BID(2), BIRC2(3), BIRC3(3), BIRC5(1), CASP1(2), CASP10(5), CASP2(3), CASP3(2), CASP4(4), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), FAS(3), FASLG(2), GZMB(2), HELLS(5), IKBKB(7), IRF1(4), IRF4(3), IRF5(3), IRF6(3), IRF7(1), JUN(3), LTA(3), MAP2K4(7), MAP3K1(9), MAPK10(5), MDM2(3), MYC(3), NFKB1(7), NFKBIA(1), NFKBIB(5), PLEKHG5(6), PRF1(1), RELA(3), RIPK1(1), TNF(1), TNFRSF10B(2), TNFRSF1A(3), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(4), TNFSF10(3), TP73(2), TRADD(2), TRAF1(3), TRAF2(2), TRAF3(3) 18277620 182 75 178 61 56 47 9 42 28 0 0.189 1.000 1.000 307 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(9), ACSS2(6), ACYP1(1), ACYP2(3), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AKR1A1(1), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), ALDOB(3), ALDOC(3), BPGM(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), G6PC2(1), GALM(3), GAPDH(1), GAPDHS(3), GCK(4), GPI(5), HK1(11), HK2(9), HK3(5), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), PDHA1(1), PDHA2(4), PDHB(3), PFKL(4), PFKM(3), PFKP(8), PGAM2(4), PGAM4(2), PGK1(4), PGK2(2), PGM1(2), PGM3(10), PKLR(5), PKM2(5), TPI1(1) 19096741 227 75 226 88 65 73 9 59 21 0 0.390 1.000 1.000 308 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 71 CALR(3), CANX(1), CD4(5), CD74(1), CD8A(4), CD8B(2), CIITA(13), CREB1(3), CTSL1(2), CTSS(1), HLA-A(7), HLA-C(3), HLA-DMA(1), HLA-DMB(3), HLA-DOA(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(6), HLA-E(3), HLA-F(7), HLA-G(3), HSP90AA1(7), HSP90AB1(6), IFI30(2), IFNA1(1), IFNA10(5), IFNA13(1), IFNA16(2), IFNA17(4), IFNA2(1), IFNA21(1), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(4), IFNA8(1), KIR2DL1(5), KIR2DL3(2), KIR2DL4(3), KIR2DS4(2), KIR3DL1(5), KIR3DL2(1), KLRC1(3), KLRC2(2), KLRC3(4), KLRD1(4), LGMN(4), LTA(3), NFYC(1), PDIA3(2), PSME1(2), PSME2(1), RFX5(6), RFXANK(3), TAP1(2), TAP2(10), TAPBP(3) 14918339 182 75 176 57 36 61 17 50 18 0 0.0897 1.000 1.000 309 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(12), ADRA1B(4), ADRA1D(2), ADRA2A(5), ADRA2C(4), ADRB1(7), ADRB2(7), CHRM1(2), CHRM2(13), CHRM3(9), CHRM4(2), CHRM5(1), DRD1(3), DRD2(7), DRD3(7), DRD4(2), DRD5(11), HRH1(4), HRH2(8), HTR1A(10), HTR1B(8), HTR1D(3), HTR1E(5), HTR1F(5), HTR2A(5), HTR2B(4), HTR2C(5), HTR4(4), HTR5A(7), HTR6(2), HTR7(8) 8415536 176 75 173 67 65 42 11 46 12 0 0.202 1.000 1.000 310 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(9), AGPAT1(3), AGPAT2(1), AGPAT3(2), AGPAT4(5), AGPS(1), CDIPT(1), CDS1(4), CDS2(2), CHAT(4), CHKA(1), CHKB(2), CLC(1), CPT1B(3), DGKA(4), DGKB(10), DGKD(2), DGKE(7), DGKG(1), DGKH(7), DGKZ(4), ETNK1(1), GNPAT(1), GPD1(6), GPD2(6), LCAT(4), PAFAH1B1(5), PAFAH2(1), PCYT1A(6), PCYT1B(5), PEMT(1), PISD(5), PLA2G2A(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PLCB2(4), PLCG1(16), PLCG2(11), PPAP2A(1), PPAP2C(4) 16351742 174 74 171 72 60 54 6 41 12 1 0.584 1.000 1.000 311 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(11), ATP4A(11), ATP4B(1), ATP5A1(2), ATP5B(3), ATP5C1(3), ATP5F1(1), ATP5G2(1), ATP5J(1), ATP5J2(1), ATP5L(2), ATP6AP1(5), ATP6V0A1(5), ATP6V0A2(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), COX10(1), COX15(5), COX4I1(3), COX4I2(1), COX6B1(2), COX7A2(1), COX7C(1), COX8C(1), LHPP(3), NDUFA1(1), NDUFA10(1), NDUFA13(3), NDUFA3(1), NDUFA6(1), NDUFA8(5), NDUFA9(2), NDUFAB1(2), NDUFB2(1), NDUFB3(2), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFB8(1), NDUFB9(1), NDUFC2(2), NDUFS1(6), NDUFS2(2), NDUFS3(1), NDUFS4(1), NDUFS5(2), NDUFS6(3), NDUFS7(3), NDUFS8(2), NDUFV1(2), PPA1(2), PPA2(3), SDHA(6), SDHB(4), SDHC(1), TCIRG1(6), UQCRB(1), UQCRC1(2), UQCRC2(3), UQCRFS1(1), UQCRQ(1) 18281319 201 74 198 87 68 63 8 48 14 0 0.799 1.000 1.000 312 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AKR1C1(1), AKR1C3(2), AKR1C4(5), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), CYP1A1(4), CYP1A2(4), CYP1B1(2), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2E1(4), CYP2F1(5), CYP2S1(7), CYP3A4(2), CYP3A43(4), CYP3A7(4), DHDH(5), EPHX1(4), GSTA1(2), GSTA2(1), GSTA4(2), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(2), GSTM5(1), GSTO2(3), GSTZ1(3), MGST1(2), MGST3(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(11), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3) 18767768 191 74 188 58 51 61 2 57 20 0 0.0670 1.000 1.000 313 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 36 AKT1(3), ATF2(1), CDC42(1), DLD(3), DUSP10(6), DUSP8(1), GAB1(2), GCK(4), IL1R1(4), JUN(3), MAP2K4(7), MAP2K5(1), MAP3K1(9), MAP3K10(8), MAP3K11(7), MAP3K12(9), MAP3K13(7), MAP3K2(3), MAP3K3(4), MAP3K4(15), MAP3K5(4), MAP3K7(8), MAP3K9(3), MAPK10(5), MAPK7(7), MAPK8(5), MAPK9(4), MYEF2(9), NFATC3(4), NR2C2(2), PAPPA(19), SHC1(3), TRAF6(5), ZAK(7) 16021854 183 74 180 68 53 55 12 34 29 0 0.441 1.000 1.000 314 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(30), ATR(13), BRCA1(14), CCNB1(3), CDC25A(3), CDC25B(4), CDC25C(7), CDC34(2), CDKN1A(1), CDKN2D(3), CHEK1(4), CHEK2(7), EP300(19), MDM2(3), MYT1(14), PRKDC(32), RPS6KA1(6), WEE1(2), YWHAH(3), YWHAQ(2) 13515884 172 73 169 49 53 47 6 43 21 2 0.104 1.000 1.000 315 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(16), CALM1(1), CALM2(3), CREB1(3), ELK1(3), FOS(1), GNAI1(1), GNAQ(3), GNAS(20), GNGT1(3), JUN(3), MAP2K1(5), MAPK3(1), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), RAF1(7), RPS6KA3(3), SYT1(3) 11459617 173 73 168 56 71 49 2 32 19 0 0.0707 1.000 1.000 316 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(9), AGXT(1), AGXT2(7), AKR1B10(2), ALAS1(2), ALAS2(9), AMT(3), AOC2(4), AOC3(4), BHMT(4), CBS(5), CHDH(4), CHKA(1), CHKB(2), CTH(2), DAO(8), DLD(3), DMGDH(7), GARS(1), GATM(3), GCAT(2), GLDC(7), GNMT(2), HSD3B7(4), MAOA(1), MAOB(3), PEMT(1), PHGDH(1), PIPOX(3), PISD(5), PSAT1(3), PSPH(3), RDH11(1), RDH12(1), RDH13(3), SARDH(10), SARS(4), SARS2(6), SDS(2), SHMT1(1), SHMT2(5), TARS(6), TARS2(5) 13993365 160 73 159 58 56 40 12 35 17 0 0.311 1.000 1.000 317 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(30), BMPR1B(4), CCND2(3), DMC1(4), EGR1(4), ESR2(8), GJA4(2), INHA(3), LHCGR(10), MLH1(3), MSH5(3), NCOR1(24), NR5A1(5), NRIP1(11), PGR(12), PRLR(2), PTGER2(4), SMPD1(5), VDR(3), ZP2(7) 11015317 147 73 145 46 43 49 5 31 16 3 0.0943 1.000 1.000 318 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(6), AKT3(6), ARHGEF11(12), BCL2(2), CDC42(1), DLG4(3), GNA13(3), LPA(14), MAP2K4(7), MAP3K1(9), MAP3K5(4), MAPK8(5), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PDK1(2), PHKA2(9), PI3(1), PIK3CB(7), PLD1(13), PLD2(13), PLD3(4), PTK2(10), RDX(4), ROCK1(9), ROCK2(7), SERPINA4(2), SRF(1), TBXA2R(8) 16107373 189 73 184 58 74 55 9 25 25 1 0.0593 1.000 1.000 319 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(4), EEF1B2(3), EEF1D(2), EEF1G(4), EEF2(4), EEF2K(7), EIF1AX(2), EIF1AY(1), EIF2AK1(3), EIF2AK2(5), EIF2AK3(10), EIF2B1(3), EIF2B2(3), EIF2B3(5), EIF2B4(6), EIF2B5(6), EIF2S1(2), EIF2S2(3), EIF4A1(3), EIF4A2(4), EIF4E(2), EIF4EBP1(2), EIF4EBP2(1), EIF4G1(19), EIF4G3(7), EIF5(5), EIF5A(3), EIF5B(10), ETF1(4), GSPT2(1), KIAA0664(8), PABPC1(2), PABPC3(8), PAIP1(2), SLC35A4(4) 14309794 158 73 156 51 51 50 7 35 15 0 0.143 1.000 1.000 320 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(9), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), AOX1(7), COMT(4), DBH(5), DCT(8), DDC(5), FAH(3), GOT1(2), GOT2(2), GSTZ1(3), HGD(3), HPD(1), MAOA(1), MAOB(3), PNMT(8), TAT(4), TH(2), TPO(15), TYR(6) 10394738 142 73 140 44 49 40 3 40 9 1 0.0607 1.000 1.000 321 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(3), BTK(2), CALM1(1), CALM2(3), CD79A(6), CD79B(1), ELK1(3), FOS(1), GRB2(4), JUN(3), LYN(4), MAP2K1(5), MAP3K1(9), MAPK14(1), MAPK3(1), MAPK8(5), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKCA(3), RAF1(7), SHC1(3), SOS1(6), SYK(6), SYT1(3), VAV1(6) 12552425 158 72 152 41 64 43 3 31 17 0 0.00685 1.000 1.000 322 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(2), CALM1(1), CALM2(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CDK5(2), F2(5), FYN(8), GNA11(5), GNAI1(1), GNGT1(3), GRB2(4), JAK2(10), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(5), MAPT(4), MYLK(15), PLCG1(16), PRKCA(3), PTK2B(10), RAF1(7), SHC1(3), SOS1(6), STAT1(7), STAT3(7), STAT5A(4), SYT1(3) 13661694 160 72 156 53 58 46 6 38 12 0 0.171 1.000 1.000 323 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(4), CALCR(6), CALCRL(6), CD97(1), CRHR1(10), CRHR2(3), ELTD1(14), EMR1(14), EMR2(9), GHRHR(4), GIPR(3), GLP1R(1), GLP2R(8), GPR64(10), LPHN1(13), LPHN2(17), LPHN3(14), SCTR(2), VIPR1(2), VIPR2(3) 8739085 144 72 141 42 36 40 6 46 16 0 0.0470 1.000 1.000 324 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ADC(1), ALDH4A1(4), ALDH5A1(5), CAD(12), CPS1(18), EARS2(3), EPRS(7), GAD1(6), GAD2(7), GCLC(1), GCLM(2), GFPT1(3), GFPT2(4), GLS(8), GLS2(6), GLUD1(3), GLUD2(10), GLUL(5), GMPS(4), GNPNAT1(2), GOT1(2), GOT2(2), GPT(1), GPT2(2), GSR(4), GSS(3), NADSYN1(4), PPAT(3), QARS(3) 12964519 139 72 138 60 43 44 5 38 9 0 0.795 1.000 1.000 325 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(5), AANAT(1), ABP1(9), ACAT1(3), ACAT2(3), ACMSD(4), AFMID(1), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), AOX1(7), ASMT(3), CARM1(4), CAT(4), CYP1A1(4), CYP1A2(4), CYP1B1(2), DDC(5), EHHADH(6), GCDH(5), HADH(3), HADHA(4), HEMK1(1), HSD17B4(4), INMT(2), KMO(1), KYNU(8), LCMT1(1), LCMT2(7), LNX1(5), MAOA(1), MAOB(3), METTL6(2), NFX1(2), OGDH(7), OGDHL(10), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), TDO2(5), TPH1(3), TPH2(5), WARS(3), WARS2(7), WBSCR22(4) 19876306 210 72 204 70 59 70 10 43 27 1 0.0967 1.000 1.000 326 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(7), AKT1(3), AKT2(6), AKT3(6), DAG1(8), GNAQ(3), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(21), ITPR3(31), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PDK1(2), PHKA2(9), PIK3CB(7), PITX2(4), PLD1(13), PLD2(13), PLD3(4), VN1R1(2) 14718492 192 72 191 61 80 48 10 39 14 1 0.0603 1.000 1.000 327 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(3), CASP3(2), CASP8(8), CRADD(1), DFFA(4), DFFB(3), JUN(3), LMNA(4), LMNB1(1), LMNB2(4), MADD(15), MAP2K4(7), MAP3K1(9), MAP3K7(8), MAPK8(5), PAK1(5), PAK2(6), PRKDC(32), RB1(6), RIPK1(1), SPTAN1(18), TNF(1), TNFRSF1A(3), TRADD(2), TRAF2(2) 12732697 155 72 152 51 47 46 8 30 24 0 0.213 1.000 1.000 328 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(8), EGF(8), EGFR(11), ELK1(3), FOS(1), GRB2(4), JAK1(6), JUN(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), PIK3R1(8), PLCG1(16), PRKCA(3), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SRF(1), STAT1(7), STAT3(7), STAT5A(4) 11595883 144 71 137 42 44 42 4 30 24 0 0.0752 1.000 1.000 329 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), ELK1(3), FPR1(4), GNA15(3), GNGT1(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K6(1), MAP3K1(9), MAPK1(2), MAPK14(1), MAPK3(1), NCF1(3), NCF2(2), NFATC1(11), NFATC2(14), NFATC3(4), NFATC4(13), NFKB1(7), NFKBIA(1), PAK1(5), PIK3C2G(7), PLCB1(13), PPP3CA(5), PPP3CB(6), PPP3CC(3), RAF1(7), RELA(3), SYT1(3) 12542950 157 71 152 56 53 43 4 35 22 0 0.271 1.000 1.000 330 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(8), ELK1(3), FOS(1), GRB2(4), JAK1(6), JUN(3), MAP2K1(5), MAP2K4(7), MAP3K1(9), MAPK3(1), MAPK8(5), PDGFA(2), PDGFRA(11), PIK3R1(8), PLCG1(16), PRKCA(3), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SRF(1), STAT1(7), STAT3(7), STAT5A(4) 10750559 138 71 131 36 40 44 4 27 23 0 0.0189 1.000 1.000 331 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(9), ACAT1(3), ACAT2(3), ACMSD(4), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), AOX1(7), ASMT(3), CAT(4), CYP19A1(9), CYP1A1(4), CYP1A2(4), CYP2A13(7), CYP2A6(6), CYP2A7(5), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2D6(4), CYP2E1(4), CYP2F1(5), CYP2J2(4), CYP3A4(2), CYP3A7(4), CYP4B1(7), CYP4F8(2), CYP51A1(6), DDC(5), EHHADH(6), GCDH(5), HADHA(4), KMO(1), KYNU(8), MAOA(1), MAOB(3), SDS(2), TDO2(5), TPH1(3), WARS(3), WARS2(7) 18080179 221 71 216 66 66 68 6 55 25 1 0.0436 1.000 1.000 332 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(6), F11(3), F12(2), F13B(13), F2(5), F5(13), F7(9), F8(15), F9(6), FGA(7), FGB(2), FGG(2), LPA(14), PLAT(4), PLAU(2), PLG(11), SERPINB2(6), SERPINE1(3), SERPINF2(5), VWF(19) 11587373 147 70 145 41 44 40 8 44 11 0 0.0354 1.000 1.000 333 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(3), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AKR1A1(1), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), ALDOB(3), ALDOC(3), BPGM(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), GAPDH(1), GCK(4), GPI(5), HK1(11), HK2(9), HK3(5), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(4), PDHB(3), PFKM(3), PFKP(8), PGK1(4), PGM1(2), PGM3(10), PKLR(5), PKM2(5), TPI1(1) 16043828 194 70 193 78 54 59 7 55 19 0 0.590 1.000 1.000 334 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(3), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AKR1A1(1), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), ALDOB(3), ALDOC(3), BPGM(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), GAPDH(1), GCK(4), GPI(5), HK1(11), HK2(9), HK3(5), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(4), PDHB(3), PFKM(3), PFKP(8), PGK1(4), PGM1(2), PGM3(10), PKLR(5), PKM2(5), TPI1(1) 16043828 194 70 193 78 54 59 7 55 19 0 0.590 1.000 1.000 335 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(9), AGMAT(1), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH4A1(4), ALDH9A1(3), AMD1(3), AOC2(4), AOC3(4), ARG1(2), ASL(5), CKB(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(18), DAO(8), GATM(3), GLUD1(3), GOT1(2), GOT2(2), MAOA(1), MAOB(3), NOS1(22), NOS3(5), ODC1(3), OTC(2), P4HA1(3), P4HA2(8), P4HA3(4), P4HB(2), PYCR1(3), RARS(4), SMS(3) 14491519 178 69 177 54 64 54 8 38 14 0 0.0376 1.000 1.000 336 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(5), CDC7(3), CDK2(3), CDT1(3), DIAPH2(6), GMNN(1), MCM10(7), MCM2(11), MCM3(3), MCM4(8), MCM5(5), MCM6(2), MCM7(5), NACA(2), ORC1L(8), ORC2L(2), ORC3L(5), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(3), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), PRIM1(2), RFC1(5), RFC2(1), RFC3(2), RFC4(1), RFC5(1), RPA1(1), RPA2(1), RPA3(2), RPA4(5), RPS27A(1), UBA52(1), UBC(5) 16668244 153 69 152 54 58 38 9 27 21 0 0.273 1.000 1.000 337 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(2), ACTN1(6), ACTN2(22), ACTN3(2), CAPN1(2), CAPNS1(2), CAPNS2(2), ITGA1(7), ITGB1(6), ITGB3(3), PTK2(10), PXN(3), SPTAN1(18), SRC(2), TLN1(14) 9349683 101 69 98 51 41 23 8 22 7 0 0.922 1.000 1.000 338 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(5), CASP3(2), CASP6(1), CASP7(2), CASP8(8), DAXX(9), DFFA(4), DFFB(3), FAF1(8), JUN(3), LMNA(4), LMNB1(1), LMNB2(4), MAP2K4(7), MAP3K1(9), MAP3K7(8), MAPK8(5), PAK1(5), PAK2(6), PRKDC(32), PTPN13(16), RB1(6), RIPK2(1), SPTAN1(18) 13388742 168 68 164 51 41 55 9 35 28 0 0.124 1.000 1.000 339 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(9), AGXT(1), AGXT2(7), ALAS1(2), ALAS2(9), AMT(3), AOC2(4), AOC3(4), BHMT(4), CBS(5), CHDH(4), CHKA(1), CHKB(2), CPT1B(3), CTH(2), DAO(8), DLD(3), DMGDH(7), GARS(1), GATM(3), GCAT(2), GLDC(7), MAOA(1), MAOB(3), PEMT(1), PISD(5), PLCB2(4), PLCG1(16), PLCG2(11), PSPH(3), SARDH(10), SARS(4), SHMT1(1), SHMT2(5), TARS(6) 13766858 161 68 158 58 50 41 10 41 19 0 0.394 1.000 1.000 340 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(9), ALDH1A3(5), ALDH3A1(4), ALDH3B1(3), ALDH3B2(7), AOC2(4), AOC3(4), DDC(5), EPX(6), ESCO1(4), ESCO2(4), GOT1(2), GOT2(2), HPD(1), LPO(7), MAOA(1), MAOB(3), MIF(1), MPO(6), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(4), TPO(15) 11214464 137 68 137 36 45 37 4 40 11 0 0.0249 1.000 1.000 341 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(9), AADAC(3), ABAT(4), ACADS(3), ACAT1(3), ACAT2(3), ACSM1(4), AKR1B10(2), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH5A1(5), ALDH9A1(3), BDH1(4), DDHD1(9), EHHADH(6), GAD1(6), GAD2(7), HADH(3), HADHA(4), HMGCS1(1), HMGCS2(3), HSD17B4(4), HSD3B7(4), ILVBL(3), L2HGDH(1), OXCT1(6), OXCT2(1), PDHA1(1), PDHA2(4), PDHB(3), PLA1A(2), PRDX6(1), RDH11(1), RDH12(1), RDH13(3) 13313100 142 68 139 62 47 37 2 39 17 0 0.820 1.000 1.000 342 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(3), ALOX15(3), ALOX5(6), CBR1(1), CBR3(3), CYP4F2(8), CYP4F3(7), EPX(6), GGT1(5), LPO(7), LTA4H(4), MPO(6), PLA2G2A(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), PTGDS(1), PTGES2(3), PTGIS(5), PTGS1(7), PTGS2(5), TBXAS1(2), TPO(15) 9135694 127 68 125 39 42 25 8 37 15 0 0.129 1.000 1.000 343 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(5), AZIN1(1), CLDN5(2), CLOCK(3), CRY1(3), CRY2(4), DAZAP2(7), DNAJA1(3), EIF4G2(5), ETV6(3), G0S2(2), GFRA1(8), GSTM3(2), HERPUD1(1), HSPA8(4), KLF9(2), MYF6(3), NCKAP1(8), NCOA4(4), NR1D2(5), PER1(5), PER2(9), PPP1R3C(3), PPP2CB(2), PSMA4(4), PURA(1), SF3A3(3), SUMO3(1), TOB1(1), TUBB3(12), UCP3(2), UGP2(3), VAPA(1), ZFR(8) 11973853 130 67 129 45 41 38 4 37 10 0 0.314 1.000 1.000 344 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(5), AKR1D1(2), ARSD(4), ARSE(4), CARM1(4), CYP11B1(7), CYP11B2(4), CYP19A1(9), HEMK1(1), HSD11B1(2), HSD11B2(2), HSD17B1(4), HSD17B12(2), HSD17B2(2), HSD17B3(1), HSD17B7(2), HSD3B1(1), HSD3B2(3), LCMT1(1), LCMT2(7), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), SRD5A1(3), SRD5A2(3), STS(4), SULT1E1(2), SULT2A1(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(11), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), WBSCR22(4) 16443905 155 67 151 58 39 57 6 36 17 0 0.301 1.000 1.000 345 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(10), ABAT(4), ACY3(1), ADSL(3), ADSS(4), ADSSL1(7), AGXT(1), AGXT2(7), ASL(5), ASNS(3), ASPA(1), ASRGL1(2), ASS1(7), CAD(12), CRAT(1), DARS(2), DARS2(1), DDO(4), DLAT(3), DLD(3), GAD1(6), GAD2(7), GOT1(2), GOT2(2), GPT(1), GPT2(2), NARS(4), PC(7), PDHA1(1), PDHA2(4), PDHB(3) 12399584 124 67 122 59 48 39 1 29 7 0 0.881 1.000 1.000 346 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(3), ALOX12B(8), ALOX15(3), ALOX15B(3), ALOX5(6), CBR1(1), CBR3(3), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2E1(4), CYP2J2(4), CYP2U1(5), CYP4A11(2), CYP4A22(2), CYP4F2(8), CYP4F3(7), EPHX2(3), GGT1(5), GPX1(4), GPX2(1), GPX3(1), GPX5(1), GPX6(3), GPX7(3), LTA4H(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), PTGDS(1), PTGES2(3), PTGIS(5), PTGS1(7), PTGS2(5), TBXAS1(2) 12750712 155 67 151 44 49 40 5 45 16 0 0.0312 1.000 1.000 347 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(19), ACACB(22), ACAT1(3), ACAT2(3), ACOT12(5), ACSS1(9), ACSS2(6), ACYP1(1), ACYP2(3), AKR1B1(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), DLAT(3), DLD(3), GLO1(1), GRHPR(2), HAGH(2), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), LDHD(3), MDH1(3), ME1(1), ME2(4), ME3(4), PC(7), PCK1(6), PCK2(7), PDHA1(1), PDHA2(4), PDHB(3), PKLR(5), PKM2(5) 15350589 181 67 179 62 55 56 6 41 23 0 0.212 1.000 1.000 348 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(10), CARS(4), CARS2(5), DARS(2), DARS2(1), EARS2(3), EPRS(7), FARS2(6), FARSA(1), FARSB(1), GARS(1), HARS(5), HARS2(2), IARS(9), IARS2(7), KARS(5), LARS(4), LARS2(7), MARS(4), MARS2(1), MTFMT(1), NARS(4), QARS(3), RARS(4), RARS2(3), SARS(4), SARS2(6), TARS(6), TARS2(5), VARS(10), VARS2(9), WARS(3), WARS2(7), YARS(3), YARS2(3) 17826650 160 67 159 57 55 49 7 38 11 0 0.435 1.000 1.000 349 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(28), B3GALT4(4), CDR1(4), DGKI(9), IL6ST(4), PIGK(3), RPL10(6), RPL12(1), RPL13A(2), RPL14(1), RPL18(1), RPL19(2), RPL24(1), RPL26(1), RPL28(1), RPL3(2), RPL31(1), RPL34(2), RPL36(1), RPL38(1), RPL3L(2), RPL5(1), RPL6(1), RPL7(1), RPL7A(2), RPL8(2), RPL9(3), RPLP0(3), RPLP1(1), RPLP2(1), RPS10(1), RPS11(1), RPS13(2), RPS14(2), RPS23(1), RPS24(1), RPS27(1), RPS27A(1), RPS3(1), RPS3A(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), RPS6KB2(3), RPS9(1), RPSA(6), SLC36A2(7), TBC1D10C(2), TSPAN9(1), UBA52(1), UBC(5) 16735247 157 67 157 71 42 55 7 38 14 1 0.927 1.000 1.000 350 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(4), ACADL(2), ACADM(4), ACADS(3), ACADSB(5), ACADVL(1), ACAT1(3), ACAT2(3), ACOX1(4), ACOX3(8), ACSL1(2), ACSL3(6), ACSL4(2), ACSL5(5), ACSL6(5), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CPT1A(7), CPT1B(3), CPT1C(6), CPT2(5), CYP4A11(2), CYP4A22(2), DCI(2), EHHADH(6), GCDH(5), HADH(3), HADHA(4), HADHB(4), HSD17B4(4), PECI(1) 16084841 166 66 163 52 44 49 6 44 23 0 0.0808 1.000 1.000 351 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(2), ASL(5), ASS1(7), CKB(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(18), DAO(8), EPRS(7), GATM(3), GLUD1(3), GLUD2(10), GOT1(2), GOT2(2), LAP3(1), NOS1(22), NOS3(5), OTC(2), P4HA1(3), P4HA2(8), P4HA3(4), PYCR1(3), PYCRL(1), RARS(4), RARS2(3) 11767967 138 66 137 43 53 38 8 32 7 0 0.0850 1.000 1.000 352 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(3), INPP4A(3), INPP4B(5), INPP5A(5), INPPL1(14), ITPKA(1), ITPKB(7), MIOX(3), OCRL(8), PIK3C2A(8), PIK3C2B(15), PIK3C2G(7), PIK3CB(7), PIK3CG(15), PLCB1(13), PLCB2(4), PLCB3(8), PLCB4(9), PLCD1(4), PLCG1(16), PLCG2(11) 13988552 166 66 159 57 59 50 7 37 13 0 0.278 1.000 1.000 353 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(1), AKT1(3), AKT2(6), AKT3(6), BAD(3), BTK(2), CDKN2A(8), DAPP1(1), GRB2(4), GSK3A(2), GSK3B(4), IARS(9), IGFBP1(5), INPP5D(1), PDK1(2), PPP1R13B(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), RPS6KB1(4), SHC1(3), SOS1(6), SOS2(11), TEC(4), YWHAB(1), YWHAE(1), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(2) 10846322 118 66 118 41 37 30 2 29 20 0 0.508 1.000 1.000 354 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 24 ARNT(1), EIF1(1), EIF2B1(3), EIF2B2(3), EIF2B3(5), EIF2B4(6), EIF2B5(6), EIF2S1(2), EIF2S2(3), ELAVL1(7), FLT1(13), FLT4(17), HIF1A(5), KDR(8), NOS3(5), PIK3R1(8), PLCG1(16), PRKCA(3), PTK2(10), PXN(3), SHC1(3) 10423240 128 66 125 34 45 34 7 27 15 0 0.0238 1.000 1.000 355 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(11), ELK1(3), GNAS(20), GNGT1(3), GRB2(4), IGF1R(15), ITGB1(6), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MKNK1(3), MKNK2(1), MYC(3), NGFR(4), PDGFRA(11), PPP2CA(3), PTPRR(7), RAF1(7), RPS6KA1(6), RPS6KA5(2), SHC1(3), SOS1(6), SRC(2), STAT3(7) 10848402 137 65 131 62 49 40 0 39 9 0 0.877 1.000 1.000 356 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(4), ATM(30), ATR(13), CCNA1(7), CCND1(1), CCNE1(3), CDC25A(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(8), E2F1(2), GSK3B(4), HDAC1(3), RB1(6), SKP2(5), TFDP1(3), TGFB1(3), TGFB2(6), TGFB3(5) 9658459 114 65 112 37 29 31 4 31 17 2 0.431 1.000 1.000 357 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(2), ARHGAP1(1), ARHGAP4(4), ARHGAP5(11), ARHGAP6(6), ARHGEF1(9), ARHGEF11(12), ARHGEF5(4), ARPC1A(3), ARPC2(1), ARPC4(2), BAIAP2(4), CFL1(1), DIAPH1(7), GSN(9), LIMK1(3), MYL2(6), MYLK(15), OPHN1(6), PIP5K1A(3), PIP5K1B(1), PPP1R12B(12), ROCK1(9), SRC(2), TLN1(14), VCL(1) 14894981 150 65 148 56 49 45 8 30 16 2 0.508 1.000 1.000 358 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(10), BLNK(3), ELK1(3), FOS(1), GRB2(4), JUN(3), LYN(4), MAP2K1(5), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8IP3(10), PAPPA(19), RPS6KA1(6), RPS6KA3(3), SHC1(3), SOS1(6), SYK(6), VAV1(6), VAV2(11), VAV3(10) 10510062 126 65 122 53 41 36 3 32 14 0 0.658 1.000 1.000 359 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), ELK1(3), FOS(1), IKBKB(7), IRAK1(6), JUN(3), LY96(1), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K14(3), MAP3K7(8), MAPK14(1), MAPK8(5), MYD88(1), NFKB1(7), NFKBIA(1), PPARA(3), RELA(3), TIRAP(1), TLR10(6), TLR2(1), TLR3(5), TLR4(18), TLR6(1), TLR7(5), TLR9(13), TOLLIP(2), TRAF6(5) 11960756 136 65 130 52 40 34 8 32 22 0 0.476 1.000 1.000 360 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(16), CD3E(2), CD4(5), CREBBP(27), CSK(5), GNAS(20), GNGT1(3), HLA-DRA(6), LCK(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PTPRC(15), ZAP70(10) 7530408 134 64 131 59 48 43 2 25 16 0 0.779 1.000 1.000 361 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), AGTR1(1), ATF2(1), CALM1(1), CALM2(3), EGFR(11), ELK1(3), GNAQ(3), GRB2(4), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K4(7), MAP3K1(9), MAPK1(2), MAPK3(1), MAPK8(5), MEF2A(1), MEF2B(4), MEF2C(3), MEF2D(6), PAK1(5), PRKCA(3), PTK2(10), PTK2B(10), RAF1(7), SHC1(3), SOS1(6), SRC(2), SYT1(3) 10994905 127 64 122 44 46 31 7 26 17 0 0.253 1.000 1.000 362 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(16), CD3E(2), CD4(5), CREBBP(27), CSK(5), GNAS(20), GNGT1(3), HLA-DRA(6), LCK(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PTPRC(15), ZAP70(10) 7530408 134 64 131 59 48 43 2 25 16 0 0.779 1.000 1.000 363 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(4), ALDH5A1(5), CAD(12), CPS1(18), EPRS(7), GAD1(6), GAD2(7), GCLC(1), GCLM(2), GFPT1(3), GLS(8), GLS2(6), GLUD1(3), GLUL(5), GMPS(4), GOT1(2), GOT2(2), GPT(1), GPT2(2), GSS(3), NADSYN1(4), PPAT(3), QARS(3) 10898744 115 64 114 48 37 39 3 29 7 0 0.736 1.000 1.000 364 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(3), AVP(3), CABIN1(13), CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), HDAC5(6), IGF1(4), IGF1R(15), INSR(12), MAP2K6(1), MAPK14(1), MAPK7(7), MEF2A(1), MEF2B(4), MEF2C(3), MEF2D(6), MYOD1(4), NFATC1(11), NFATC2(14), PIK3R1(8), PPP3CA(5), PPP3CB(6), PPP3CC(3), SYT1(3), YWHAH(3) 10667257 145 64 144 49 55 41 4 25 20 0 0.0875 1.000 1.000 365 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(5), ALG10(6), ALG10B(3), ALG12(3), ALG13(7), ALG14(1), ALG3(2), ALG5(2), ALG6(2), ALG8(1), ALG9(1), B4GALT1(2), B4GALT2(5), B4GALT3(2), DHDDS(3), DOLPP1(2), DPAGT1(1), DPM1(1), FUT8(3), GANAB(4), MAN1A1(2), MAN1A2(3), MAN1B1(5), MAN1C1(2), MAN2A1(3), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(3), MGAT5(8), MGAT5B(4), RFT1(3), RPN1(2), RPN2(3), STT3B(3) 13892080 108 64 107 57 34 30 7 19 17 1 0.961 1.000 1.000 366 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(3), DLG4(3), GRIN1(4), GRIN2A(11), GRIN2B(18), GRIN2C(4), GRIN2D(4), NOS1(22), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), SYT1(3) 8368958 112 64 112 52 44 28 3 23 14 0 0.751 1.000 1.000 367 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(11), DIAPH1(7), FYN(8), GSN(9), ITGA1(7), ITGB1(6), MAP2K1(5), MAPK1(2), MAPK3(1), MYL2(6), MYLK(15), PIK3R1(8), PTK2(10), PXN(3), RAF1(7), ROCK1(9), SHC1(3), SRC(2), TLN1(14) 11546890 133 63 129 36 35 36 9 33 18 2 0.0580 1.000 1.000 368 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(5), ARRB2(1), CALM1(1), CALM2(3), CALML3(1), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CLCA1(8), CLCA2(5), CLCA4(7), CNGA3(7), CNGA4(17), CNGB1(10), GNAL(2), GUCA1A(2), GUCA1B(2), GUCA1C(3), PDC(1), PDE1C(5), PRKACA(3), PRKACB(2), PRKACG(5), PRKG1(8), PRKG2(10), PRKX(4) 10020003 129 63 124 47 49 30 4 33 13 0 0.283 1.000 1.000 369 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 ADAM17(5), APC(35), AXIN1(8), BTRC(5), DLL1(10), DVL1(5), FZD1(7), GSK3B(4), NOTCH1(20), PSEN1(2), WNT1(5) 6446712 106 63 102 42 39 15 5 19 25 3 0.600 1.000 1.000 370 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(30), ATR(13), BRCA1(14), BRCA2(27), CHEK1(4), CHEK2(7), FANCA(5), FANCC(4), FANCD2(10), FANCE(2), FANCG(3), HUS1(2), MRE11A(2), RAD1(2), RAD17(4), RAD50(9), RAD51(1), RAD9A(2) 14236642 141 62 140 32 30 42 6 42 19 2 0.0346 1.000 1.000 371 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(9), ACY3(1), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH3B1(3), ALDH3B2(7), ALDH9A1(3), AOC2(4), AOC3(4), ASPA(1), CARM1(4), CNDP1(1), DDC(5), FTCD(2), HAL(1), HARS(5), HARS2(2), HDC(7), HEMK1(1), HNMT(2), LCMT1(1), LCMT2(7), MAOA(1), MAOB(3), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), PRPS1(2), PRPS2(2), UROC1(8), WBSCR22(4) 12993177 133 62 132 42 40 39 6 34 14 0 0.120 1.000 1.000 372 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(5), ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(6), GLB1(2), GNS(3), GUSB(8), HEXA(2), HEXB(2), HGSNAT(3), HPSE(6), HPSE2(2), HYAL1(4), HYAL2(4), IDS(3), IDUA(2), LCT(15), MAN2B1(10), MAN2B2(12), MAN2C1(7), MANBA(5), NAGLU(3), NEU1(1), NEU2(3), NEU3(4), NEU4(1), SPAM1(8) 11267026 126 62 124 44 45 43 7 20 11 0 0.201 1.000 1.000 373 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2B(2), GTF2E1(4), GTF2E2(2), GTF2F1(5), GTF2F2(1), GTF2H1(1), GTF2H3(2), GTF2H4(3), GTF2I(6), GTF2IRD1(11), TAF1(13), TAF10(1), TAF13(1), TAF1L(19), TAF2(8), TAF4(10), TAF4B(3), TAF5(2), TAF5L(3), TAF6(8), TAF6L(4), TAF7(5), TAF7L(3), TAF9B(3), TBPL1(2), TBPL2(5) 11829191 129 62 126 34 37 37 9 27 19 0 0.0330 1.000 1.000 374 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(7), ADCY3(5), ADCY9(8), AK1(1), ARF1(4), ARF4(1), ARL4D(1), ATP6V0A1(5), ATP6V0A2(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), ERO1L(1), GNAS(20), PDIA4(1), PLCG1(16), PLCG2(11), PRKCA(3), SEC61A1(3), SEC61B(1), SEC61G(1), TRIM23(3) 12143535 136 62 132 56 54 32 5 34 11 0 0.663 1.000 1.000 375 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(4), CALM1(1), CALM2(3), CRKL(1), GNAQ(3), GRB2(4), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(7), MAP2K4(7), MAP3K1(9), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(5), PAK1(5), PLCG1(16), PRKCA(3), PTK2B(10), RAF1(7), SHC1(3), SOS1(6), SRC(2), SYT1(3) 9329121 113 62 107 32 40 30 4 25 14 0 0.0750 1.000 1.000 376 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(3), EGR2(6), EGR3(5), GNAQ(3), MAP3K1(9), MYC(3), NFATC1(11), NFATC2(14), NFKB1(7), NFKBIA(1), PLCG1(16), PPP3CA(5), PPP3CB(6), PPP3CC(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RELA(3), SYT1(3), VIP(3), VIPR2(3) 9170775 127 62 123 41 49 34 2 25 17 0 0.102 1.000 1.000 377 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(5), BAK1(3), BAX(1), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP2(3), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), FAS(3), FASLG(2), GZMB(2), JUN(3), MAP2K4(7), MAP3K1(9), MAP3K14(3), MAPK10(5), MCL1(1), MDM2(3), MYC(3), NFKB1(7), NFKBIA(1), PARP1(7), PRF1(1), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(2), TNFSF10(3), TRADD(2), TRAF1(3), TRAF2(2) 11983207 114 61 111 41 34 28 3 31 18 0 0.370 1.000 1.000 378 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(2), ACP5(1), ACPP(2), ACPT(4), ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), CYP19A1(9), CYP1A1(4), CYP1A2(4), CYP2A13(7), CYP2A6(6), CYP2A7(5), CYP2B6(6), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2D6(4), CYP2E1(4), CYP2F1(5), CYP2J2(4), CYP3A4(2), CYP3A7(4), CYP4B1(7), CYP4F8(2), CYP51A1(6), PON1(2) 9619453 124 61 122 43 52 30 4 27 11 0 0.230 1.000 1.000 379 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(16), EXT2(5), EXTL1(4), EXTL2(2), EXTL3(10), GLCE(3), HS2ST1(2), HS3ST1(2), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(3), HS3ST5(6), HS6ST1(2), HS6ST2(4), HS6ST3(6), NDST1(10), NDST2(6), NDST3(10), NDST4(13) 6771461 114 61 111 34 37 33 4 31 9 0 0.153 1.000 1.000 380 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(5), BAIAP2(4), CASP1(2), CASP3(2), CASP7(2), CASP8(8), GAPDH(1), INSR(12), ITCH(4), MAGI1(14), MAGI2(23), RERE(18), WWP1(9), WWP2(10) 7867633 114 61 108 36 31 29 7 23 24 0 0.251 1.000 1.000 381 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(11), ATP4B(1), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), ATP7A(8), ATP7B(11), COX10(1), COX4I1(3), COX6B1(2), COX7A2(1), COX7C(1), NDUFA1(1), NDUFA10(1), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(6), NDUFS2(2), NDUFV1(2), PPA2(3), SDHA(6), SDHB(4), SHMT1(1), UQCRB(1), UQCRC1(2), UQCRFS1(1) 12526073 141 61 139 56 46 43 6 32 14 0 0.589 1.000 1.000 382 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(3), BRAF(9), CREB1(3), CREB3(4), CREB5(4), DUSP6(3), DUSP9(3), EEF2K(7), EIF4E(2), GRB2(4), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), MKNK1(3), MKNK2(1), MOS(9), NFKB1(7), RAP1A(2), RPS6KA1(6), RPS6KA2(8), RPS6KA3(3), SHC1(3), SOS1(6), SOS2(11), TRAF3(3) 9672183 114 61 110 46 35 31 2 30 16 0 0.655 1.000 1.000 383 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA2(4), ACADM(4), ACADS(3), ACAT1(3), ACAT2(3), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), AOX1(7), AUH(7), BCAT1(3), BCAT2(5), BCKDHA(5), BCKDHB(1), DBT(2), DLD(3), EHHADH(6), HADH(3), HADHA(4), HADHB(4), HIBADH(3), HMGCS1(1), HMGCS2(3), HSD17B4(4), IVD(4), MCCC1(3), MCCC2(3), MCEE(3), MUT(3), OXCT1(6), OXCT2(1), PCCA(9), PCCB(4) 14129026 150 60 145 53 38 50 3 31 27 1 0.401 1.000 1.000 384 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(3), ARSD(4), ARSE(4), ASAH1(2), B4GALT6(2), CERK(5), DEGS1(2), DEGS2(1), ENPP7(5), GAL3ST1(6), GALC(5), GBA(6), GLB1(2), LCT(15), NEU1(1), NEU2(3), NEU3(4), NEU4(1), PPAP2A(1), PPAP2C(4), SGMS1(2), SGMS2(2), SGPP1(1), SGPP2(1), SMPD1(5), SMPD2(1), SMPD3(9), SMPD4(7), SPHK1(4), SPHK2(2), SPTLC1(1), SPTLC2(3), UGCG(3), UGT8(4) 11697205 121 60 120 46 50 38 5 16 12 0 0.275 1.000 1.000 385 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(1), CREB1(3), DAXX(9), DDIT3(3), ELK1(3), GRB2(4), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K5(4), MAP3K7(8), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MAX(3), MEF2A(1), MEF2B(4), MEF2C(3), MEF2D(6), MKNK1(3), MYC(3), PLA2G4A(4), RIPK1(1), RPS6KA5(2), SHC1(3), STAT1(7), TGFB1(3), TGFB2(6), TGFB3(5), TGFBR1(5), TRADD(2), TRAF2(2) 12026493 122 60 119 41 36 36 5 21 24 0 0.259 1.000 1.000 386 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(3), AKT2(6), AKT3(6), BAD(3), BCL2(2), GRB2(4), GSK3A(2), GSK3B(4), IL4R(1), IRS1(15), IRS2(4), JAK1(6), JAK3(9), MAP4K1(3), MAPK1(2), MAPK3(1), PDK1(2), PIK3CD(10), PIK3R1(8), PPP1R13B(6), RAF1(7), SHC1(3), SOCS1(1), SOS1(6), SOS2(11), STAT6(1) 11253385 126 60 122 40 50 31 2 26 17 0 0.185 1.000 1.000 387 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), DAG1(8), ITPKA(1), ITPKB(7), ITPR1(21), ITPR2(21), ITPR3(31), NFAT5(9), PDE6A(4), PDE6B(8), PDE6C(3), PDE6G(1), SLC6A13(5), TF(6) 11741959 137 60 136 58 58 33 8 27 10 1 0.521 1.000 1.000 388 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(1), GHR(6), GRB2(4), INSR(12), IRS1(15), JAK2(10), MAP2K1(5), MAPK1(2), MAPK3(1), PIK3R1(8), PLCG1(16), PRKCA(3), PTPN6(3), RAF1(7), RPS6KA1(6), SHC1(3), SLC2A4(4), SOCS1(1), SOS1(6), SRF(1), STAT5A(4), STAT5B(6) 10135840 124 59 120 37 40 42 2 22 18 0 0.0814 1.000 1.000 389 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(3), ALDOC(3), DLAT(3), DLD(3), ENO1(2), ENO2(3), ENO3(4), FBP1(2), FBP2(4), GAPDH(1), GAPDHS(3), GCK(4), GOT1(2), GOT2(2), GPI(5), HK1(11), HK2(9), HK3(5), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), MDH1(3), PC(7), PCK1(6), PDHA1(1), PDHA2(4), PDHB(3), PDHX(2), PFKL(4), PFKM(3), PFKP(8), PGAM2(4), PGK1(4), PGK2(2), PKLR(5), PKM2(5), TNFAIP1(4), TPI1(1) 13937519 147 59 145 68 57 46 3 33 8 0 0.766 1.000 1.000 390 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(6), AKR1B10(2), B4GALT1(2), B4GALT2(5), G6PC2(1), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANC(7), GCK(4), GLB1(2), HK1(11), HK2(9), HK3(5), HSD3B7(4), LALBA(1), LCT(15), MGAM(9), PFKL(4), PFKM(3), PFKP(8), PGM1(2), PGM3(10), RDH11(1), RDH12(1), RDH13(3), UGP2(3) 12646519 126 59 125 62 51 40 2 24 9 0 0.862 1.000 1.000 391 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(4), ALAS1(2), ALAS2(9), BLVRA(3), COX10(1), COX15(5), CP(9), CPOX(2), EARS2(3), EPRS(7), FECH(6), FTH1(3), FTMT(3), GUSB(8), HCCS(1), HMBS(2), HMOX1(5), HMOX2(1), MMAB(2), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(11), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), UROD(1), UROS(3) 13808126 133 59 131 57 30 44 6 41 12 0 0.804 1.000 1.000 392 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(5), AASDH(5), AASS(6), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BBOX1(3), DLST(4), DOT1L(8), EHHADH(6), EHMT1(10), EHMT2(6), GCDH(5), HADHA(4), PLOD1(7), PLOD2(6), PLOD3(8), SDS(2), SHMT1(1), SHMT2(5), TMLHE(5) 12112794 138 59 136 51 44 47 2 24 21 0 0.253 1.000 1.000 393 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(7), GTF2A1(2), GTF2B(2), GTF2E1(4), GTF2F1(5), HDAC3(4), NCOA1(12), NCOA2(21), NCOA3(11), NCOR2(21), POLR2A(15), RARA(2), RXRA(3), TBP(2) 8158428 111 59 110 51 31 42 3 24 11 0 0.808 1.000 1.000 394 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(7), GTF2B(2), GTF2E1(4), GTF2E2(2), GTF2F2(1), GTF2H1(1), GTF2H4(3), ILK(3), MNAT1(2), POLR1A(12), POLR1B(4), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3B(9), POLR3D(4), POLR3E(3), POLR3K(1), TAF13(1), TAF5(2), TAF6(8), TAF7(5), TBP(2) 11501047 110 59 108 45 40 36 2 20 12 0 0.635 1.000 1.000 395 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(7), DYRK1B(7), GLI2(11), GLI3(33), GSK3B(4), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), SHH(4), SMO(10), SUFU(5) 5437712 103 59 103 42 42 22 4 28 7 0 0.405 1.000 1.000 396 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(3), AKT2(6), AKT3(6), CISH(1), GRB2(4), IARS(9), IL13RA1(3), IL2RG(5), IL4(1), IL4R(1), INPP5D(1), JAK1(6), JAK2(10), JAK3(9), NR0B2(2), PI3(1), PPP1R13B(6), RPS6KB1(4), SERPINA4(2), SHC1(3), SOS1(6), SOS2(11), SRC(2), STAT6(1), TYK2(4) 11389156 107 59 105 38 32 29 2 29 15 0 0.561 1.000 1.000 397 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(6), CFL1(1), GNAQ(3), GNAS(20), GNGT1(3), LIMK1(3), MAP2K1(5), MAPK1(2), MAPK3(1), MYL2(6), NOX1(4), PIK3C2G(7), PLCB1(13), PPP1R12B(12), PRKCA(3), PTK2(10), RAF1(7), ROCK2(7) 8273506 114 58 110 32 42 23 4 29 16 0 0.201 1.000 1.000 398 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(5), C1GALT1(3), C1GALT1C1(4), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(7), GALNT14(6), GALNT2(4), GALNT3(2), GALNT4(2), GALNT5(7), GALNT6(2), GALNT8(5), GALNT9(2), GALNTL1(7), GALNTL2(8), GALNTL4(7), GALNTL5(3), GCNT3(2), GCNT4(2), OGT(2), ST3GAL1(4), ST3GAL2(4), ST6GALNAC1(2) 10206868 102 58 101 47 36 26 4 28 8 0 0.916 1.000 1.000 399 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(2), CAPN1(2), CAPN2(3), CAPNS1(2), CAPNS2(2), EGF(8), EGFR(11), ITGA1(7), ITGB1(6), MAPK1(2), MAPK3(1), MYL2(6), MYLK(15), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PTK2(10), PXN(3), TLN1(14) 10719086 116 58 114 53 44 31 7 24 10 0 0.711 1.000 1.000 400 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(27), DUSP1(2), EP300(19), IKBKB(7), IL1B(2), IL8(1), MAP2K3(7), MAP2K6(1), MAP3K14(3), MAP3K7(8), MAPK11(1), MAPK14(1), MYD88(1), NFKB1(7), NFKBIA(1), NR3C1(5), RELA(3), TGFBR1(5), TGFBR2(11), TLR2(1), TNF(1) 9714449 114 58 113 37 32 34 8 21 19 0 0.232 1.000 1.000 401 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(19), ACAT1(3), ACAT2(3), ACYP1(1), ACYP2(3), ADH5(3), AKR1B1(6), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), DLAT(3), DLD(3), GLO1(1), GRHPR(2), HAGH(2), LDHA(3), LDHB(4), LDHC(1), LDHD(3), MDH1(3), ME1(1), ME2(4), ME3(4), PC(7), PCK1(6), PDHA1(1), PDHA2(4), PDHB(3), PKLR(5), PKM2(5) 12121292 139 58 137 53 43 48 3 29 16 0 0.479 1.000 1.000 402 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ABP1(9), ACADL(2), ACADM(4), ACADSB(5), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), CNDP1(1), DPYD(12), DPYS(7), EHHADH(6), GAD1(6), GAD2(7), HADHA(4), MLYCD(5), SDS(2), SMS(3), UPB1(2) 9540105 123 57 119 41 35 41 4 32 11 0 0.158 1.000 1.000 403 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(9), ABAT(4), ACADS(3), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH5A1(5), ALDH9A1(3), EHHADH(6), GAD1(6), GAD2(7), HADHA(4), L2HGDH(1), OXCT1(6), PDHA1(1), PDHA2(4), PDHB(3), SDHB(4), SDS(2) 8462762 107 57 105 46 36 32 0 26 13 0 0.721 1.000 1.000 404 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(4), ACAD8(3), ACAD9(5), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH5(3), ADH6(5), ADH7(1), ADHFE1(8), AKR1B10(2), AKR1C4(5), AKR1D1(2), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BAAT(1), CEL(7), CYP27A1(4), CYP7A1(4), HADHB(4), HSD3B7(4), LIPA(1), RDH11(1), RDH12(1), RDH13(3), SLC27A5(4), SOAT1(6), SOAT2(2), SRD5A1(3), SRD5A2(3) 10386794 124 57 122 39 31 43 5 30 15 0 0.109 1.000 1.000 405 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(19), ACACB(22), ACADM(4), ACAT1(3), ACAT2(3), ACSS1(9), ACSS2(6), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), EHHADH(6), HADHA(4), LDHA(3), LDHAL6B(4), LDHB(4), LDHC(1), MCEE(3), MLYCD(5), MUT(3), PCCA(9), PCCB(4), SUCLA2(4), SUCLG1(2), SUCLG2(2) 13039588 156 57 151 43 41 46 4 38 27 0 0.0526 1.000 1.000 406 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(3), CDK5(2), CDK5R1(1), CFL1(1), CHN1(3), LIMK1(3), MAP3K1(9), MYL2(6), MYLK(15), NCF2(2), PAK1(5), PDGFRA(11), PIK3R1(8), PLD1(13), PPP1R12B(12), RALBP1(5), RPS6KB1(4), TRIO(26), VAV1(6), WASF1(3) 10749995 138 57 136 50 43 44 2 29 20 0 0.430 1.000 1.000 407 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(16), AKT1(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CREB1(3), GNAS(20), GRB2(4), MAPK1(2), MAPK14(1), MAPK3(1), PIK3R1(8), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3), RPS6KA1(6), RPS6KA5(2), SOS1(6) 8828321 109 56 108 44 42 35 0 19 13 0 0.642 1.000 1.000 408 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(6), AKR1B10(2), ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), FPGT(3), FUK(3), GMDS(2), GMPPA(6), GMPPB(2), HK1(11), HK2(9), HK3(5), HSD3B7(4), KHK(2), LHPP(3), MPI(3), MTMR1(4), MTMR2(3), MTMR6(5), PFKFB1(2), PFKFB2(5), PFKFB3(3), PFKFB4(3), PFKL(4), PFKM(3), PFKP(8), PGM2(1), PHPT1(2), PMM1(2), PMM2(2), RDH11(1), RDH12(1), RDH13(3), SORD(2), TPI1(1), TSTA3(6) 12181843 134 56 134 46 52 44 2 26 10 0 0.122 1.000 1.000 409 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(3), BAD(3), BCL2(2), CBL(2), CRKL(1), E2F1(2), FOS(1), GRB2(4), IL2RA(2), IL2RB(2), IL2RG(5), IRS1(15), JAK1(6), JAK3(9), MAPK1(2), MAPK3(1), MYC(3), NMI(2), PIK3R1(8), PTPN6(3), RAF1(7), RPS6KB1(4), SHC1(3), SOCS1(1), SOCS3(3), SOS1(6), STAT5A(4), STAT5B(6), SYK(6) 11122696 116 56 113 41 31 41 1 25 18 0 0.393 1.000 1.000 410 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(2), DLG4(3), EPHB2(8), F2(5), F2RL1(2), F2RL2(2), F2RL3(1), JUN(3), MAP2K5(1), MAPK1(2), MAPK7(7), MAPK8(5), MYEF2(9), PLD1(13), PLD2(13), PLD3(4), PTK2(10), RAF1(7), RASAL1(4), SRC(2), TEC(4), VAV1(6) 8978757 113 56 112 30 38 34 6 20 15 0 0.0291 1.000 1.000 411 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(29), MAP2(24), PPP1CA(2), PPP2CA(3), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAR2A(2), PRKAR2B(7), PRKCE(8) 5961212 85 55 84 29 14 29 2 27 13 0 0.526 1.000 1.000 412 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(5), BCL2(2), BID(2), BIRC2(3), BIRC3(3), CASP10(5), CASP3(2), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), GAS2(2), LMNA(4), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), SPTAN1(18), TNFRSF10A(1), TNFRSF10B(2), TNFRSF25(4), TNFSF10(3), TRADD(2), TRAF2(2) 10941157 95 55 93 31 27 24 2 28 14 0 0.435 1.000 1.000 413 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNA1(1), IFNB1(2), IKBKB(7), IL1A(2), IL1B(2), IL1R1(4), IL1RAP(5), IL1RN(1), IRAK1(6), IRAK2(8), IRAK3(4), JUN(3), MAP2K3(7), MAP2K6(1), MAP3K1(9), MAP3K14(3), MAP3K7(8), MAPK14(1), MAPK8(5), MYD88(1), NFKB1(7), NFKBIA(1), RELA(3), TGFB1(3), TGFB2(6), TGFB3(5), TNF(1), TOLLIP(2), TRAF6(5) 9724136 113 55 110 37 35 29 6 26 17 0 0.285 1.000 1.000 414 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(16), AKT1(3), BAD(3), BAX(1), BCL2(2), CSF2RB(7), IGF1(4), IGF1R(15), IL3(1), IL3RA(5), KIT(12), KITLG(2), PIK3R1(8), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), YWHAH(3) 6478074 104 54 103 43 34 37 2 21 10 0 0.429 1.000 1.000 415 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(6), B4GALT1(2), B4GALT2(5), FBP2(4), GAA(2), GALE(1), GALK1(2), GALK2(2), GALT(1), GANAB(4), GCK(4), GLB1(2), HK1(11), HK2(9), HK3(5), LALBA(1), LCT(15), MGAM(9), PFKM(3), PFKP(8), PGM1(2), PGM3(10) 10668999 108 54 107 54 45 31 2 19 11 0 0.878 1.000 1.000 416 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(8), ACO2(5), CLYBL(1), CS(2), DLD(3), DLST(4), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(3), MDH1(3), OGDH(7), OGDHL(10), PC(7), PCK1(6), PCK2(7), SDHA(6), SDHB(4), SDHC(1), SUCLA2(4), SUCLG1(2), SUCLG2(2) 9815813 96 54 92 37 44 23 5 11 13 0 0.406 1.000 1.000 417 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ABP1(9), ACADM(4), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), AOC2(4), AOC3(4), CNDP1(1), DPYD(12), DPYS(7), EHHADH(6), GAD1(6), GAD2(7), HADHA(4), MLYCD(5), SMS(3), SRM(1), UPB1(2) 8861538 107 54 103 34 31 34 4 28 10 0 0.122 1.000 1.000 418 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(5), POLA2(3), POLB(2), POLD1(10), POLD2(1), POLD3(3), POLE(17), POLE2(3), POLE3(1), POLG(5), POLG2(4), POLH(5), POLI(1), POLK(6), POLL(2), POLM(3), POLQ(22), PRIM1(2), PRIM2(6), REV1(7), REV3L(23), RFC5(1) 13329313 132 54 132 52 38 36 5 30 23 0 0.733 1.000 1.000 419 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(11), ANAPC10(1), ANAPC11(1), ANAPC2(4), ANAPC5(2), ANAPC7(3), BTRC(5), CDC16(4), CDC20(4), CDC23(4), CDC26(1), CDC27(2), CUL1(14), CUL2(5), CUL3(5), FBXW11(10), FZR1(3), ITCH(4), RBX1(1), SKP2(5), SMURF1(3), SMURF2(3), TCEB1(1), UBA1(3), UBE2D3(2), UBE2E3(3), WWP1(9), WWP2(10) 12652439 123 54 118 35 44 43 1 21 14 0 0.0752 1.000 1.000 420 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 BCL2(2), CREBBP(27), EP300(19), FYN(8), IL2RG(5), IL7(1), IL7R(6), JAK1(6), JAK3(9), LCK(3), NMI(2), PIK3R1(8), PTK2B(10), STAT5A(4), STAT5B(6) 8446462 116 54 113 32 33 36 1 26 20 0 0.0779 1.000 1.000 421 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), CDC42(1), CREB1(3), CREB3(4), CREB5(4), DUSP1(2), DUSP10(6), EEF2K(7), EIF4E(2), ELK1(3), IL1R1(4), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K10(8), MAP3K4(15), MAP3K5(4), MAP3K7(8), MAPK1(2), MAPK11(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MKNK1(3), MKNK2(1), MYEF2(9), NFKB1(7), NR2C2(2), SRF(1), TRAF6(5) 10922282 124 54 123 42 35 42 10 20 17 0 0.141 1.000 1.000 422 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(1), CSNK1D(2), DRD1(3), DRD2(7), GRM1(26), PLCB1(13), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(5), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 5251638 87 53 85 33 30 25 1 20 11 0 0.444 1.000 1.000 423 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(3), ASNS(3), ASRGL1(2), CA13(3), CA14(3), CA2(1), CA3(3), CA4(3), CA5B(1), CA6(3), CA7(3), CA8(3), CA9(4), CPS1(18), CTH(2), GLS(8), GLS2(6), GLUD1(3), GLUD2(10), GLUL(5), HAL(1) 6974059 88 53 88 35 21 31 3 26 7 0 0.647 1.000 1.000 424 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(7), IL1A(2), IL1R1(4), IRAK1(6), MAP3K1(9), MAP3K14(3), MAP3K7(8), MYD88(1), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TLR4(18), TNF(1), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(2), TRADD(2), TRAF6(5) 7959028 88 53 84 30 25 20 5 25 13 0 0.399 1.000 1.000 425 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(2), EGF(8), EGFR(11), GRB2(4), MAP2K1(5), MAPK1(2), MAPK3(1), PTPRB(17), RAF1(7), RASA1(11), SHC1(3), SOS1(6), SPRY1(2), SPRY3(6), SPRY4(4), SRC(2) 8197714 91 53 88 33 26 22 2 32 9 0 0.615 1.000 1.000 426 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(6), ACTN2(22), ACTN3(2), BCAR1(4), CSK(5), CTNNA1(11), CTNNA2(16), PTK2(10), PXN(3), SRC(2), VCL(1) 5730138 82 52 81 42 30 17 6 21 8 0 0.919 1.000 1.000 427 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(16), AKT1(3), ASAH1(2), GNAI1(1), GNGT1(3), ITGAV(5), ITGB3(3), MAPK1(2), MAPK3(1), PDGFA(2), PDGFRA(11), PIK3R1(8), PLCB1(13), PRKCA(3), PTK2(10), SMPD1(5), SMPD2(1), SPHK1(4), SRC(2) 8291921 95 52 94 42 31 33 4 13 14 0 0.639 1.000 1.000 428 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(2), ADCY1(16), CAP1(3), CCNB1(3), CDC25C(7), GNAI1(1), GNAS(20), GNGT1(3), MAPK1(2), MAPK3(1), MYT1(14), PIN1(1), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RPS6KA1(6), SRC(2) 6741430 103 52 101 44 40 26 1 26 10 0 0.722 1.000 1.000 429 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(11), ARHGEF1(9), GNA12(1), GNA13(3), GNAQ(3), GNGT1(3), MYL2(6), MYLK(15), PLCB1(13), PPP1R12B(12), PRKCA(3), ROCK1(9) 6794253 88 52 86 29 24 23 2 23 14 2 0.471 1.000 1.000 430 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(16), ARHGEF1(9), F2(5), F2R(2), F2RL3(1), GNA12(1), GNA13(3), GNAI1(1), GNAQ(3), GNGT1(3), MAP3K7(8), PIK3R1(8), PLCB1(13), PPP1R12B(12), PRKCA(3), PTK2B(10), ROCK1(9) 7761854 107 52 106 43 34 32 2 21 17 1 0.659 1.000 1.000 431 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(19), ACADL(2), ACADM(4), ACADSB(5), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), EHHADH(6), HADHA(4), LDHA(3), LDHB(4), LDHC(1), MCEE(3), MLYCD(5), MUT(3), PCCA(9), PCCB(4), SDS(2), SUCLA2(4), SUCLG1(2), SUCLG2(2) 10874139 132 52 127 38 34 46 1 29 22 0 0.130 1.000 1.000 432 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 DUSP1(2), GORASP1(3), MAP2K4(7), MAPK1(2), MAPK10(5), MAPK11(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(5), MAPK8IP1(2), MAPK8IP2(3), MAPK8IP3(10), MAPK9(4), MAPKAPK5(1), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), PIK3CD(10), PIK3R1(8), SYT1(3), TRAF2(2), TRAF3(3), TRAF6(5) 10037206 103 52 102 31 42 26 3 15 17 0 0.0780 1.000 1.000 433 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(5), F2R(2), F2RL3(1), GNAI1(1), GNGT1(3), ITGA1(7), ITGB1(6), MAP2K1(5), MAPK1(2), MAPK3(1), PLA2G4A(4), PLCB1(13), PRKCA(3), PTGS1(7), PTK2(10), RAF1(7), SRC(2), SYK(6), TBXAS1(2) 7991998 87 52 83 36 28 21 6 21 11 0 0.653 1.000 1.000 434 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(6), ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), FPGT(3), GCK(4), GMDS(2), GMPPA(6), GMPPB(2), HK1(11), HK2(9), HK3(5), KHK(2), MPI(3), PFKFB1(2), PFKFB3(3), PFKFB4(3), PFKM(3), PFKP(8), PMM1(2), PMM2(2), SORD(2), TPI1(1) 7856467 91 51 91 31 41 25 1 18 6 0 0.142 1.000 1.000 435 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(4), CHIT1(3), CMAS(4), CTBS(2), CYB5R1(1), CYB5R3(1), GFPT1(3), GFPT2(4), GNE(5), GNPDA1(3), GNPDA2(2), GNPNAT1(2), HEXA(2), HEXB(2), HK1(11), HK2(9), HK3(5), LHPP(3), MTMR1(4), MTMR2(3), MTMR6(5), NANS(1), NPL(2), PGM3(10), PHPT1(2), RENBP(2), UAP1(3) 9415778 100 51 100 32 27 36 4 25 8 0 0.163 1.000 1.000 436 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(21), C5(11), C6(10), C7(2), ICAM1(1), IL1A(2), IL8(1), ITGA4(9), ITGAL(11), ITGB1(6), ITGB2(5), SELP(6), SELPLG(6), TNF(1), VCAM1(8) 8155883 100 51 98 35 35 24 3 29 9 0 0.260 1.000 1.000 437 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(3), EIF4A1(3), EIF4A2(4), EIF4B(4), EIF4E(2), EIF4EBP1(2), EIF4G1(19), EIF4G2(5), EIF4G3(7), FKBP1A(2), MKNK1(3), PDPK1(2), PIK3R1(8), PPP2CA(3), RPS6(1), RPS6KB1(4), TSC1(3), TSC2(7) 8077172 82 51 82 26 26 26 3 16 11 0 0.318 1.000 1.000 438 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(18), COL4A2(10), COL4A3(8), COL4A4(10), COL4A5(9), COL4A6(6), P4HB(2), SLC23A1(4), SLC23A2(9), SLC2A1(6), SLC2A3(5) 8239432 87 51 87 43 32 29 2 19 5 0 0.695 1.000 1.000 439 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(4), CREB1(3), CREBBP(27), EP300(19), NCOA3(11), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), RARA(2), RXRA(3) 6778303 91 50 89 36 31 32 1 13 14 0 0.441 1.000 1.000 440 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(2), EPHA4(14), EPHB1(18), FYN(8), ITGA1(7), ITGB1(6), L1CAM(12), LYN(4), RAP1B(5), SELP(6) 5190737 82 50 80 33 32 15 8 21 5 1 0.487 1.000 1.000 441 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(2), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), CHST1(13), CHST2(10), CHST4(4), CHST6(6), FUT8(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4) 4083927 70 50 68 28 39 16 1 11 3 0 0.429 1.000 1.000 442 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), CYP2C19(7), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), EHHADH(6), ESCO1(4), ESCO2(4), HADHA(4), MYST3(20), MYST4(15), NAT6(2), PNPLA3(1), SH3GLB1(1), YOD1(2) 10139122 111 50 110 31 31 37 2 26 15 0 0.0722 1.000 1.000 443 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(4), ACADL(2), ACADM(4), ACADS(3), ACADSB(5), ACAT1(3), ACAT2(3), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH6A1(4), ALDH9A1(3), AOX1(7), BCAT1(3), BCKDHA(5), BCKDHB(1), EHHADH(6), HADHA(4), HADHB(4), HIBADH(3), IVD(4), MCCC1(3), MCCC2(3), MCEE(3), MUT(3), OXCT1(6), PCCA(9), PCCB(4), SDS(2) 11820864 134 50 130 51 29 52 2 27 23 1 0.575 1.000 1.000 444 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(6), AGT(3), AGTR1(1), AGTR2(2), COL4A1(18), COL4A2(10), COL4A3(8), COL4A4(10), COL4A5(9), COL4A6(6), REN(2) 8301669 75 49 75 31 25 24 3 20 3 0 0.401 1.000 1.000 445 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(4), ADSL(3), ADSS(4), AGXT(1), AGXT2(7), ASL(5), ASNS(3), ASPA(1), CAD(12), CRAT(1), DARS(2), DDO(4), GAD1(6), GAD2(7), GOT1(2), GOT2(2), GPT(1), GPT2(2), NARS(4), PC(7) 8542230 82 49 80 44 34 26 0 19 3 0 0.922 1.000 1.000 446 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(4), CARM1(4), CBS(5), CTH(2), GGT1(5), HEMK1(1), LCMT1(1), LCMT2(7), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), METTL6(2), PAPSS1(4), PAPSS2(4), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), SCLY(1), SEPHS1(4), SEPHS2(2), WBSCR22(4) 8183586 75 49 73 40 24 21 4 14 12 0 0.899 1.000 1.000 447 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(4), ADH1A(3), ADH1B(3), ADH1C(2), ADH4(2), ADH6(5), ADH7(1), ADHFE1(8), AKR1C4(5), AKR1D1(2), ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), BAAT(1), CEL(7), CYP27A1(4), CYP7A1(4), HADHB(4), SOAT2(2), SRD5A1(3), SRD5A2(3) 7624006 99 48 98 36 25 33 2 25 14 0 0.355 1.000 1.000 448 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(9), CHAT(4), COMT(4), DBH(5), DDC(5), GAD1(6), GAD2(7), HDC(7), MAOA(1), PAH(4), PNMT(8), SLC18A3(7), TH(2), TPH1(3) 4707288 73 48 72 38 30 17 2 20 4 0 0.858 1.000 1.000 449 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(6), CD2(2), CD33(7), CD5(4), CD7(3), IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL12A(2), IL12B(1), IL13(1), IL3(1), IL4(1), ITGAX(8), TLR2(1), TLR4(18), TLR7(5), TLR9(13) 6104533 80 48 75 41 23 17 5 28 7 0 0.941 1.000 1.000 450 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(6), DCXR(1), GUSB(8), RPE(4), UGDH(5), UGP2(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(3), UGT2A3(3), UGT2B10(11), UGT2B11(2), UGT2B15(2), UGT2B28(5), UGT2B4(3), UGT2B7(3), XYLB(5) 8903723 83 48 81 26 18 29 3 26 7 0 0.202 1.000 1.000 451 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(8), ELK1(3), FOS(1), GRB2(4), IL6R(1), IL6ST(4), JAK1(6), JAK2(10), JAK3(9), JUN(3), MAP2K1(5), MAPK3(1), PTPN11(5), RAF1(7), SHC1(3), SOS1(6), SRF(1), STAT3(7) 7830204 84 48 81 34 20 29 1 31 3 0 0.673 1.000 1.000 452 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(2), DLAT(3), DLD(3), DLST(4), FH(2), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(3), MDH1(3), OGDH(7), PC(7), PDHA1(1), PDHA2(4), PDHB(3), PDHX(2), PDK1(2), PDK3(4), PDK4(2), PDP2(4), SDHA(6), SDHB(4), SDHC(1), SUCLA2(4), SUCLG1(2), SUCLG2(2) 9315063 84 48 82 42 28 25 2 16 13 0 0.933 1.000 1.000 453 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(3), BIRC3(3), CASP3(2), CASP8(8), JUN(3), MAP2K4(7), MAP3K3(4), MAP3K7(8), NFKB1(7), NFKB2(2), NFKBIA(1), NFKBIB(5), NFKBIL1(2), NFKBIL2(7), NR2C2(2), RALBP1(5), RIPK1(1), TNF(1), TNFAIP3(5), TNFRSF1A(3), TNFRSF1B(2), TRADD(2), TRAF2(2) 8913854 86 48 86 32 29 19 6 20 12 0 0.456 1.000 1.000 454 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(3), BCL2(2), EGFR(11), IGF1R(15), MYC(3), POLR2A(15), PPP2CA(3), PRKCA(3), RB1(6), TEP1(22), TERF1(3), TERT(3), TNKS(13), XRCC5(4) 8986276 106 48 104 45 31 42 4 21 8 0 0.531 1.000 1.000 455 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX15(3), ALOX5(6), CYP1A2(4), CYP2C18(3), CYP2C19(7), CYP2C8(1), CYP2E1(4), CYP2J2(4), CYP3A4(2), CYP3A43(4), CYP3A7(4), HSD3B7(4), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(1), PLA2G2D(1), PLA2G2E(4), PLA2G3(8), PLA2G4A(4), PLA2G5(1), PLA2G6(5), RDH11(1), RDH12(1), RDH13(3) 7853020 82 47 82 27 24 26 3 23 6 0 0.254 1.000 1.000 456 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(13), APOA1(5), APOA4(5), APOC2(1), APOE(1), CETP(3), CYP7A1(4), DGAT1(1), HMGCR(6), LCAT(4), LDLR(7), LIPC(2), LPL(4), LRP1(26), SCARB1(4), SOAT1(6) 8995945 92 47 89 40 40 18 7 20 7 0 0.694 1.000 1.000 457 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(4), DARS(2), EPRS(7), FARS2(6), GARS(1), HARS(5), IARS(9), KARS(5), LARS(4), LARS2(7), MARS(4), MARS2(1), NARS(4), QARS(3), RARS(4), SARS(4), TARS(6), WARS(3), WARS2(7), YARS(3) 10538377 93 46 92 29 29 30 3 22 9 0 0.237 1.000 1.000 458 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(7), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(3), CCNH(2), CDC25A(3), CDK2(3), CDK6(4), CDKN1A(1), CDKN2A(8), CDKN2D(3), E2F1(2), RB1(6), RBL1(7), TFDP1(3) 5270869 61 46 59 23 14 22 2 16 7 0 0.567 1.000 1.000 459 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(16), GNAS(20), GNGT1(3), PPP2CA(3), PRKAA1(4), PRKAA2(5), PRKAB1(2), PRKAB2(2), PRKACB(2), PRKACG(5), PRKAG1(3), PRKAG2(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 5032008 83 46 82 34 32 24 1 17 9 0 0.694 1.000 1.000 460 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(15), POLR2B(9), POLR2C(2), POLR2E(2), POLR2F(1), POLR2G(1), POLR2I(1), POLR2K(1), POLR3A(15), POLR3B(9), POLR3G(2), POLR3K(1) 7710349 78 46 76 24 28 25 1 20 4 0 0.195 1.000 1.000 461 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(3), ASNS(3), CA14(3), CA2(1), CA3(3), CA4(3), CA5B(1), CA6(3), CA7(3), CA8(3), CA9(4), CPS1(18), CTH(2), GLS(8), GLS2(6), GLUD1(3), GLUL(5), HAL(1) 6241441 73 46 73 33 16 28 3 19 7 0 0.833 1.000 1.000 462 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(4), GPLD1(8), PGAP1(8), PIGA(2), PIGB(5), PIGC(3), PIGG(8), PIGK(3), PIGL(2), PIGM(5), PIGN(5), PIGO(4), PIGP(1), PIGQ(2), PIGS(3), PIGT(2), PIGU(1), PIGV(4), PIGW(1), PIGX(2), PIGZ(2) 7810694 75 45 73 32 22 24 2 18 8 1 0.654 1.000 1.000 463 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(16), ADRB2(7), GNAS(20), PLCE1(11), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 4845460 76 45 75 40 31 24 0 14 7 0 0.932 1.000 1.000 464 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(27), EP300(19), HDAC3(4), IKBKB(7), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(2), TRADD(2), TRAF6(5) 7319376 82 45 81 30 28 23 2 15 14 0 0.436 1.000 1.000 465 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(3), CRADD(1), IKBKB(7), JUN(3), LTA(3), MAP2K3(7), MAP2K4(7), MAP2K6(1), MAP3K1(9), MAP3K14(3), MAP4K2(4), MAPK14(1), MAPK8(5), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TANK(3), TNF(1), TNFRSF1A(3), TRADD(2), TRAF2(2) 7876599 77 45 75 29 23 21 5 11 17 0 0.497 1.000 1.000 466 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(3), ARSB(2), ARSD(4), ARSE(4), ASAH1(2), GAL3ST1(6), GALC(5), GBA(6), GLB1(2), LCT(15), NEU1(1), NEU2(3), NEU3(4), NEU4(1), PPAP2A(1), PPAP2C(4), SMPD1(5), SMPD2(1), SPTLC1(1), SPTLC2(3), UGCG(3) 7922149 76 44 75 31 33 27 3 7 6 0 0.436 1.000 1.000 467 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(2), GNS(3), GUSB(8), HEXA(2), HEXB(2), HGSNAT(3), HPSE(6), HPSE2(2), HYAL1(4), HYAL2(4), IDS(3), IDUA(2), LCT(15), NAGLU(3), SPAM1(8) 6697252 70 44 69 28 21 28 3 13 5 0 0.500 1.000 1.000 468 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(9), AMT(3), ATIC(6), FTCD(2), GART(8), MTFMT(1), MTHFD1(3), MTHFD1L(6), MTHFD2(1), MTHFR(6), MTHFS(1), MTR(12), SHMT1(1), SHMT2(5), TYMS(1) 6208573 65 44 63 26 19 16 4 13 13 0 0.531 1.000 1.000 469 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(7), DDX20(4), E2F1(2), E2F4(1), ETS1(5), ETS2(3), ETV3(1), FOS(1), HDAC2(2), HDAC5(6), JUN(3), NCOR2(21), RBL1(7), RBL2(4), SIN3A(8), SIN3B(10) 8479106 86 43 86 33 29 21 4 23 9 0 0.537 1.000 1.000 470 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(6), F2(5), F2R(2), F3(1), F5(13), F7(9), FGA(7), FGB(2), FGG(2), PROC(2), PROS1(8), SERPINC1(4), TFPI(3) 5388988 64 43 64 24 19 18 4 20 3 0 0.530 1.000 1.000 471 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), G6PD(2), GPI(5), H6PD(4), PFKL(4), PFKM(3), PFKP(8), PGD(6), PGLS(2), PGM1(2), PGM3(10), PRPS1(2), PRPS1L1(2), PRPS2(2), RBKS(1), RPE(4), RPIA(1), TALDO1(4), TKT(3), TKTL1(8), TKTL2(7) 7958475 92 43 92 32 29 32 5 20 6 0 0.162 1.000 1.000 472 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(6), G6PD(2), GCLC(1), GCLM(2), GGT1(5), GPX1(4), GPX2(1), GPX3(1), GPX5(1), GPX6(3), GPX7(3), GSR(4), GSS(3), GSTA1(2), GSTA2(1), GSTA4(2), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(2), GSTM5(1), GSTO2(3), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST3(2), OPLAH(5), TXNDC12(1) 7178462 68 43 66 29 22 18 1 21 6 0 0.652 1.000 1.000 473 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(7), BST1(2), C9orf95(1), CD38(3), ENPP1(5), ENPP3(4), NADK(6), NADSYN1(4), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(1), NNT(11), NT5C(1), NT5C1A(4), NT5C1B(5), NT5C2(7), NT5C3(1), NUDT12(3) 7052766 68 43 66 38 22 23 3 10 9 1 0.939 1.000 1.000 474 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(5), ARHGDIB(1), BIRC2(3), BIRC3(3), CASP1(2), CASP10(5), CASP2(3), CASP3(2), CASP4(4), CASP6(1), CASP7(2), CASP8(8), CASP9(2), DFFA(4), DFFB(3), GZMB(2), LMNA(4), LMNB1(1), LMNB2(4), PRF1(1) 6328543 60 42 59 22 19 15 5 15 6 0 0.553 1.000 1.000 475 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(7), EGF(8), EGFR(11), GRB2(4), MET(7), PDGFRA(11), PRKCA(3), SH3GLB1(1), SH3GLB2(5), SH3KBP1(10), SRC(2) 6383057 71 42 69 39 26 19 2 13 11 0 0.942 1.000 1.000 476 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(16), ADRB2(7), CFTR(8), GNAS(20), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7) 4283034 73 42 72 34 30 21 0 15 7 0 0.859 1.000 1.000 477 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(8), ACO2(5), CS(2), DLD(3), DLST(4), FH(2), IDH1(1), IDH2(1), IDH3A(1), IDH3B(2), IDH3G(3), MDH1(3), PC(7), PCK1(6), SDHA(6), SDHB(4), SUCLA2(4), SUCLG1(2), SUCLG2(2) 6765651 66 42 63 28 32 15 1 10 8 0 0.561 1.000 1.000 478 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(8), EGFR(11), MAP2K1(5), MAP3K1(9), MAPK14(1), NCOR2(21), RARA(2), RXRA(3), THRA(4), THRB(7) 5644405 71 42 68 34 30 18 1 14 8 0 0.826 1.000 1.000 479 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(4), AMD1(3), BHMT(4), CBS(5), CTH(2), DNMT1(12), DNMT3A(5), DNMT3B(9), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), MTAP(1), MTFMT(1), MTR(12), SRM(1), TAT(4) 6799749 72 42 70 40 23 26 2 13 8 0 0.926 1.000 1.000 480 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(5), FUCA1(1), FUCA2(1), GLB1(2), HEXA(2), HEXB(2), LCT(15), MAN2B1(10), MAN2B2(12), MAN2C1(7), MANBA(5), NEU1(1), NEU2(3), NEU3(4), NEU4(1) 6663517 71 42 70 27 29 20 3 11 8 0 0.460 1.000 1.000 481 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(4), B4GALNT1(3), GLB1(2), HEXA(2), HEXB(2), LCT(15), SLC33A1(4), ST3GAL1(4), ST3GAL2(4), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC5(1), ST6GALNAC6(2), ST8SIA1(4), ST8SIA5(4) 5403872 58 42 58 34 25 15 1 13 4 0 0.955 1.000 1.000 482 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22RA1(1), IL22RA2(1), JAK1(6), JAK2(10), JAK3(9), SOCS3(3), STAT1(7), STAT3(7), STAT5A(4), STAT5B(6), TYK2(4) 6019507 62 42 61 23 17 18 2 20 5 0 0.529 1.000 1.000 483 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 26 ANXA1(2), ANXA2(1), ANXA4(3), ANXA5(1), ANXA6(2), CYP11A1(4), EDN1(2), EDNRA(3), HSD11B1(2), HSD11B2(2), PLA2G4A(4), PRL(1), PTGDR(6), PTGDS(1), PTGER2(4), PTGER4(4), PTGFR(3), PTGIS(5), PTGS1(7), PTGS2(5), S100A6(1), TBXAS1(2) 6476015 65 42 65 36 16 18 5 20 6 0 0.973 1.000 1.000 484 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(4), ARFGAP1(2), ARFGAP3(4), ARFGEF2(19), CLTA(2), CLTB(1), COPA(6), GBF1(14), GPLD1(8), KDELR1(2), KDELR2(2) 5335434 64 41 64 23 22 29 1 10 2 0 0.244 1.000 1.000 485 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(3), C1S(5), C2(2), C3(21), C5(11), C6(10), C7(2), C8A(5), C9(6), MASP1(3), MASP2(4), MBL2(1) 7007514 74 41 72 26 24 19 4 16 10 1 0.519 1.000 1.000 486 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(3), BCAT2(5), IARS(9), IARS2(7), ILVBL(3), LARS(4), LARS2(7), PDHA1(1), PDHA2(4), PDHB(3), VARS(10), VARS2(9) 6103991 65 41 65 25 21 18 2 16 8 0 0.679 1.000 1.000 487 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), GOT1(2), GOT2(2), GPT(1), GPT2(2), MDH1(3), ME1(1), ME3(4), PGK1(4), PGK2(2), PKLR(5), PKM2(5), RPE(4), RPIA(1), TKT(3), TKTL1(8), TKTL2(7), TPI1(1) 6615512 67 41 67 34 23 21 4 16 3 0 0.856 1.000 1.000 488 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(9), AMT(3), ATIC(6), GART(8), MTHFD1(3), MTHFD1L(6), MTHFD2(1), MTHFR(6), MTHFS(1), MTR(12), SHMT1(1), SHMT2(5), TYMS(1) 5872118 62 41 60 22 18 16 4 12 12 0 0.323 1.000 1.000 489 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), FDXR(3), SHMT1(1) 5259322 66 41 64 23 17 21 3 16 9 0 0.395 1.000 1.000 490 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(5), AKR1D1(2), ARSB(2), ARSD(4), ARSE(4), CYP11B1(7), CYP11B2(4), HSD11B1(2), HSD11B2(2), HSD17B2(2), HSD17B3(1), HSD3B1(1), HSD3B2(3), SRD5A1(3), SRD5A2(3), STS(4), SULT1E1(2), SULT2A1(3), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3) 8941815 78 40 78 29 22 32 2 13 9 0 0.320 1.000 1.000 491 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), SHMT1(1) 4945363 63 40 61 22 15 21 3 16 8 0 0.421 1.000 1.000 492 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), SHMT1(1) 4945363 63 40 61 22 15 21 3 16 8 0 0.421 1.000 1.000 493 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(5), GABRA1(12), GABRA2(5), GABRA3(7), GABRA4(7), GABRA5(5), GABRA6(8), GPHN(9), NSF(1), SRC(2), UBQLN1(4) 3926090 65 40 65 25 12 14 9 27 3 0 0.673 1.000 1.000 494 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(6), G6PD(2), GCLC(1), GCLM(2), GGT1(5), GPX1(4), GPX2(1), GPX3(1), GPX5(1), GSS(3), GSTA1(2), GSTA2(1), GSTA4(2), GSTM2(1), GSTM3(2), GSTM4(2), GSTM5(1), GSTO2(3), GSTZ1(3), IDH1(1), IDH2(1), MGST1(2), MGST3(2), PGD(6) 5906218 55 40 53 18 18 14 0 18 5 0 0.278 1.000 1.000 495 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT1(3), B3GNT2(2), B3GNT3(5), B3GNT4(4), B3GNT5(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT4(4), FUT1(2), FUT3(1), FUT4(1), FUT5(2), FUT6(2), FUT7(2), FUT9(5), GCNT2(1), ST3GAL6(3), ST8SIA1(4) 5278238 54 40 53 22 21 16 2 12 3 0 0.539 1.000 1.000 496 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(2), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT5(5), DPAGT1(1), DPM1(1), FUT8(3), MAN1A1(2), MAN1B1(5), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(3), MGAT5(8), RPN1(2), RPN2(3) 6520781 57 40 56 32 21 13 5 11 7 0 0.950 1.000 1.000 497 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), G6PD(2), GPI(5), H6PD(4), PFKM(3), PFKP(8), PGD(6), PGLS(2), PGM1(2), PGM3(10), PRPS1(2), PRPS1L1(2), PRPS2(2), RBKS(1), RPE(4), RPIA(1), TAL1(1), TALDO1(4), TKT(3) 6701187 74 40 74 27 24 24 4 17 5 0 0.237 1.000 1.000 498 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(4), BLVRA(3), CP(9), CPOX(2), EPRS(7), FECH(6), GUSB(8), HCCS(1), HMBS(2), HMOX1(5), HMOX2(1), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(2), UGT2B4(3), UROD(1), UROS(3) 8975452 78 40 78 32 20 29 1 19 9 0 0.665 1.000 1.000 499 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(6), ATP6V0B(2), ATP6V0D1(6), ATP6V1A(5), ATP6V1B1(10), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(6), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(5), SHMT1(1) 4945363 63 40 61 22 15 21 3 16 8 0 0.421 1.000 1.000 500 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(3), ALDOC(3), FBP1(2), FBP2(4), GOT1(2), GOT2(2), GPT(1), GPT2(2), MDH1(3), ME1(1), ME2(4), ME3(4), PGK1(4), PKLR(5), PKM2(5), RPE(4), RPIA(1), TKT(3), TPI1(1) 5914458 54 39 54 27 18 18 3 12 3 0 0.805 1.000 1.000 501 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(8), EGFR(11), ERBB3(29), NRG1(11) 3381148 59 39 53 22 23 15 2 17 2 0 0.560 1.000 1.000 502 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(9), ABCC2(11), ABCG2(3), BCHE(11), CES1(8), CES2(5), CYP3A4(2), UGT1A1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A5(8), UGT1A6(1), UGT1A7(1), UGT1A8(1), UGT1A9(2) 7512643 68 39 68 29 18 22 2 18 8 0 0.704 1.000 1.000 503 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(3), AKT2(6), AKT3(6), CDKN1A(1), ELK1(3), GRB2(4), MAP2K1(5), MAP2K2(2), NGFR(4), NTRK1(6), PIK3CD(10), SHC1(3), SOS1(6) 4562751 59 39 56 23 25 16 1 17 0 0 0.508 1.000 1.000 504 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(2), HSPA1A(1), IFNG(2), IFNGR1(5), IFNGR2(1), IKBKB(7), JAK2(10), LIN7A(7), NFKB1(7), NFKBIA(1), RB1(6), RELA(3), TNF(1), TNFRSF1A(3), TNFRSF1B(2), USH1C(2), WT1(3) 5686226 63 39 61 25 14 19 1 22 7 0 0.681 1.000 1.000 505 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(3), BAD(3), CHRNB1(1), CHRNG(4), MUSK(7), PIK3R1(8), PTK2(10), PTK2B(10), RAPSN(2), SRC(2), TERT(3), YWHAH(3) 4633640 56 38 56 21 18 13 5 11 9 0 0.502 1.000 1.000 506 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(4), CDKN2A(8), E2F1(2), MDM2(3), MYC(3), PIK3R1(8), POLR1A(12), POLR1B(4), POLR1C(2), POLR1D(1), RB1(6), TBX2(3), TWIST1(1) 5657242 57 38 56 28 18 17 1 9 12 0 0.862 1.000 1.000 507 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(6), AGT(3), AGTR2(2), EDN1(2), EDNRA(3), EGF(8), EGFR(11), FOS(1), JUN(3), MYC(3), NFKB1(7), PLCG1(16), PRKCA(3), RELA(3) 6452386 71 38 69 27 24 17 5 21 4 0 0.467 1.000 1.000 508 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(3), C1S(5), C2(2), C3(21), C5(11), C6(10), C7(2), C8A(5), C9(6) 5756517 66 38 64 24 21 16 4 16 8 1 0.630 1.000 1.000 509 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(10), POLD2(1), POLE(17), POLG(5), POLL(2), POLQ(22) 5484674 59 38 59 31 18 13 3 15 10 0 0.947 1.000 1.000 510 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(1), RPL10A(1), RPL10L(9), RPL12(1), RPL13A(2), RPL14(1), RPL18(1), RPL19(2), RPL22L1(1), RPL23A(1), RPL24(1), RPL26(1), RPL28(1), RPL3(2), RPL31(1), RPL34(2), RPL36A(1), RPL38(1), RPL3L(2), RPL6(1), RPL7(1), RPL8(2), RPL9(3), RPS10(1), RPS11(1), RPS13(2), RPS23(1), RPS24(1), RPS27(1), RPS3(1), RPS3A(2), RPS4Y1(1), RPS5(3), RPS6(1), RPS9(1), RPSA(6) 7417354 62 38 62 27 19 22 1 12 8 0 0.858 1.000 1.000 511 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(6), ACE2(6), AGT(3), AGTR1(1), AGTR2(2), ANPEP(6), CPA3(1), CTSA(1), CTSG(3), ENPEP(9), LNPEP(8), MAS1(1), MME(5), NLN(6), REN(2), THOP1(4) 6936406 64 38 64 28 24 22 3 13 2 0 0.601 1.000 1.000 512 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(5), CLOCK(3), CRY1(3), CRY2(4), CSNK1D(2), CSNK1E(7), NPAS2(9), NR1D1(4), PER1(5), PER2(9), PER3(8) 5582542 59 38 59 22 16 13 3 17 10 0 0.608 1.000 1.000 513 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), CAT(4), EPX(6), LPO(7), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), SHMT1(1), SHMT2(5), TPO(15) 3855470 52 38 52 18 17 10 4 12 9 0 0.423 1.000 1.000 514 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(4), BHMT(4), CBS(5), CTH(2), DNMT1(12), DNMT3A(5), DNMT3B(9), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), MTR(12) 5701888 62 38 60 35 22 20 2 10 8 0 0.921 1.000 1.000 515 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(4), ICAM1(1), ITGA4(9), ITGAL(11), ITGAM(6), ITGB1(6), ITGB2(5), SELE(4), SELL(4), SELP(6) 5240905 56 38 55 31 22 10 1 15 8 0 0.937 1.000 1.000 516 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(2), CCR2(5), CCR3(6), CCR5(3), CCR7(2), CD4(5), CXCR4(1), IFNG(2), IFNGR1(5), IFNGR2(1), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL18R1(2), IL4(1), IL4R(1), TGFB1(3), TGFB2(6), TGFB3(5) 6573665 65 38 65 30 17 17 2 23 6 0 0.833 1.000 1.000 517 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(7), ESR2(8), ITPKA(1), PDE1A(6), PDE1B(3), PLCB1(13), PLCB2(4), PRL(1), TRH(3), VIP(3) 3641575 49 38 48 22 16 12 4 14 3 0 0.764 1.000 1.000 518 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(7), DNMT1(12), MTNR1A(4), MTNR1B(6), PTAFR(5), PTGDR(6), PTGER2(4), PTGER4(4), PTGFR(3), TBXA2R(8) 3644520 59 38 59 32 24 17 3 13 2 0 0.808 1.000 1.000 519 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(6), GBA3(1), LPO(7), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(1), TPO(15), TYR(6) 3150845 46 37 46 21 13 11 4 14 4 0 0.806 1.000 1.000 520 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(20), GNGT1(3), PRKACB(2), PRKACG(5), PRKAR1A(3), PRKAR1B(3), PRKAR2A(2), PRKAR2B(7), PRKCA(3) 3149049 51 36 50 17 24 11 2 9 5 0 0.423 1.000 1.000 521 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP2(2), ACP5(1), ACP6(2), ACPP(2), ACPT(4), ALPI(6), ALPL(4), ALPP(7), ALPPL2(6), CYP3A4(2), CYP3A43(4), CYP3A7(4), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), PON1(2), PON2(3), PON3(1) 5910298 62 36 61 28 25 18 1 11 7 0 0.632 1.000 1.000 522 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(3), AKT2(6), AKT3(6), BPNT1(1), GRB2(4), ILK(3), MAPK1(2), MAPK3(1), PDK1(2), PIK3CD(10), PTK2B(10), RBL2(4), SHC1(3), SOS1(6) 5713748 61 36 60 18 29 14 0 14 4 0 0.303 1.000 1.000 523 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(2), IKBKAP(6), IKBKB(7), LTA(3), MAP3K1(9), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3), RIPK1(1), TANK(3), TNFAIP3(5), TNFRSF1B(2), TRAF1(3), TRAF2(2), TRAF3(3) 7365885 60 36 58 25 22 13 2 11 12 0 0.734 1.000 1.000 524 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(6), ARG1(2), ASL(5), CKB(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(18), GATM(3), GLUD1(3), NAGS(1), ODC1(3), OTC(2), PYCR1(3), SMS(3) 5735231 62 36 62 21 23 17 3 17 2 0 0.291 1.000 1.000 525 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(6), DHCR24(2), DHCR7(3), EBP(1), FDPS(6), GGCX(2), GGPS1(2), HMGCR(6), HSD17B7(2), LSS(4), MVD(2), MVK(8), NQO1(2), NSDHL(3), SC4MOL(4), SC5DL(4), SQLE(4), TM7SF2(1) 6316156 65 35 63 24 19 16 3 17 10 0 0.613 1.000 1.000 526 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(11), HK2(9), HK3(5), IMPA1(3), IMPA2(1), ISYNA1(2), PGM1(2), PGM3(10), TGDS(3) 3826449 50 35 50 20 15 18 2 12 3 0 0.430 1.000 1.000 527 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(6), GBA(6), GBA3(1), LPO(7), MPO(6), PRDX6(1), TPO(15) 2737617 42 35 42 17 16 11 2 10 3 0 0.608 1.000 1.000 528 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(7), FOS(1), GRB2(4), IL3(1), IL3RA(5), JAK2(10), MAP2K1(5), MAPK3(1), PTPN6(3), RAF1(7), SHC1(3), SOS1(6), STAT5A(4), STAT5B(6) 5806936 63 35 60 24 20 22 0 18 3 0 0.552 1.000 1.000 529 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(4), ESR1(7), GREB1(20), MTA1(6), MTA3(2), PDZK1(2), TUBA8(4) 3576892 45 35 45 21 18 15 3 5 4 0 0.574 1.000 1.000 530 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(5), FUCA1(1), FUCA2(1), GLB1(2), HEXA(2), HEXB(2), LCT(15), MAN2C1(7), MANBA(5), NEU1(1), NEU2(3), NEU3(4), NEU4(1) 5403449 49 35 49 22 17 15 2 8 7 0 0.783 1.000 1.000 531 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(2), GNS(3), GUSB(8), HEXA(2), HEXB(2), IDS(3), IDUA(2), LCT(15), NAGLU(3) 4691627 43 34 43 23 13 17 0 9 4 0 0.843 1.000 1.000 532 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(2), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(1), ARPC4(2), NCK1(6), NCKAP1(8), NTRK1(6), PIR(1), PSMA7(4), WASF1(3), WASF2(6), WASF3(6), WASL(2) 5011433 54 33 53 28 24 15 2 6 7 0 0.858 1.000 1.000 533 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(2), IKBKAP(6), IKBKB(7), MAP3K1(9), MAP3K14(3), NFKB1(7), NFKBIA(1), RELA(3), TNFAIP3(5), TRAF3(3), TRAF6(5) 5950050 51 33 49 17 19 11 2 9 10 0 0.483 1.000 1.000 534 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(6), CD44(4), CSF1(1), FCGR3A(3), IL1B(2), IL6R(1), SELL(4), SPN(3), TGFB1(3), TGFB2(6), TNF(1), TNFRSF1A(3), TNFRSF1B(2), TNFRSF8(2), TNFSF8(3) 4313736 44 33 44 27 15 11 0 12 6 0 0.946 1.000 1.000 535 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6R(1), JAK1(6), JAK2(10), JAK3(9), PIAS3(2), PTPRU(16), REG1A(3), SRC(2), STAT3(7) 4997029 57 33 56 26 18 19 0 17 3 0 0.782 1.000 1.000 536 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD4(5), FYN(8), HLA-DRA(6), LCK(3), PTPRC(15), ZAP70(10) 2967631 49 33 47 23 13 18 1 15 2 0 0.834 1.000 1.000 537 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(2), ACP5(1), ACP6(2), ACPP(2), ACPT(4), ENPP1(5), ENPP3(4), FLAD1(3), LHPP(3), MTMR1(4), MTMR2(3), MTMR6(5), PHPT1(2), RFK(1), TYR(6) 4937950 47 32 47 17 10 17 3 12 5 0 0.432 1.000 1.000 538 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(4), ACOX3(8), ELOVL2(4), ELOVL5(2), ELOVL6(1), FADS1(2), FADS2(4), FASN(14), HADHA(4), HSD17B12(2), SCD(1) 4650230 46 32 42 22 22 8 2 7 7 0 0.734 1.000 1.000 539 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), HMOX1(5), IL10(2), IL10RA(4), IL10RB(2), IL1A(2), JAK1(6), STAT1(7), STAT3(7), STAT5A(4), TNF(1) 4009679 43 32 43 16 11 11 1 16 4 0 0.575 1.000 1.000 540 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(3), CD3E(2), ETV5(5), IFNG(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL18(1), IL18R1(2), JAK2(10), JUN(3), MAP2K6(1), MAPK14(1), MAPK8(5), STAT4(3), TYK2(4) 6120380 57 32 56 23 10 22 4 15 6 0 0.683 1.000 1.000 541 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(7), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(2), CDK2(3), CDKN2A(8), E2F1(2), E2F2(3), E2F4(1), PRB1(2) 2933001 33 31 33 18 5 14 1 7 6 0 0.924 1.000 1.000 542 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(2), CD8A(4), ICAM1(1), ITGAL(11), ITGB2(5), PTPRC(15), THY1(1) 3533188 41 31 39 19 11 12 2 13 3 0 0.783 1.000 1.000 543 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(4), FUT1(2), FUT9(5), GBGT1(1), HEXA(2), HEXB(2), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST8SIA1(4) 3327035 36 30 36 15 18 5 0 11 2 0 0.646 1.000 1.000 544 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(2), B4GALT2(5), B4GALT3(2), B4GALT5(5), FUT8(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(1), ST3GAL4(4) 2580773 33 30 32 11 16 9 1 6 1 0 0.399 1.000 1.000 545 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 13 GALNT1(2), GALNT10(5), GALNT2(4), GALNT3(2), GALNT4(2), GALNT6(2), GALNT8(5), GALNT9(2), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4) 4344528 36 30 36 15 17 5 2 9 3 0 0.711 1.000 1.000 546 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(1), PSMA3(2), PSMA4(4), PSMA6(4), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(1), PSMC3(6), RPN1(2), RPN2(3), UBE2A(1), UBE3A(5) 4248563 45 30 44 18 14 16 5 6 4 0 0.569 1.000 1.000 547 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(6), JAK2(10), JAK3(9), PIAS1(6), PIAS3(2), PTPRU(16), REG1A(3), SOAT1(6) 4497587 59 30 57 23 17 19 2 14 7 0 0.677 1.000 1.000 548 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(6), JAK2(10), JAK3(9), MAPK1(2), MAPK3(1), STAT3(7), TYK2(4) 3831596 39 30 38 17 10 15 0 12 2 0 0.730 1.000 1.000 549 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD3E(2), CD4(5), ICAM1(1), ITGAL(11), ITGB2(5), PTPRC(15), THY1(1) 3706941 42 30 40 22 11 12 1 15 3 0 0.917 1.000 1.000 550 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 6 ADCY1(16), CREM(3), FHL5(1), FSHB(1), GNAS(20), XPO1(5) 2678065 46 29 44 22 20 11 0 11 4 0 0.950 1.000 1.000 551 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(16), GNAS(20), GNGT1(3), PRKACA(3), PRKAR1A(3) 2169317 45 29 44 19 20 10 0 9 6 0 0.802 1.000 1.000 552 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(4), B3GALNT1(2), B3GALT5(1), FUT1(2), FUT9(5), GBGT1(1), HEXA(2), HEXB(2), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST8SIA1(4) 3531535 35 29 35 17 17 4 1 11 2 0 0.816 1.000 1.000 553 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(4), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), HEMK1(1), LCMT1(1), LCMT2(7), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(4), PRMT8(3), WBSCR22(4) 4932363 47 29 46 17 14 17 1 9 6 0 0.341 1.000 1.000 554 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(4), IL2RG(5), IL4(1), IL4R(1), IRS1(15), JAK1(6), JAK3(9), RPS6KB1(4), SHC1(3), STAT6(1) 4845760 52 29 50 22 16 17 0 9 10 0 0.776 1.000 1.000 555 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3), EHHADH(6), HADHA(4), SDS(2) 3988987 48 29 47 20 13 15 0 11 9 0 0.642 1.000 1.000 556 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(4), ICAM1(1), ITGA4(9), ITGAL(11), ITGB1(6), ITGB2(5), SELE(4), SELL(4) 3986353 44 29 43 23 17 10 1 10 6 0 0.822 1.000 1.000 557 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(7), CD38(3), ENPP1(5), ENPP3(4), NADSYN1(4), NMNAT1(1), NMNAT2(1), NNMT(1), NNT(11), NT5C(1) 4764617 38 29 37 24 7 11 3 10 6 1 0.974 1.000 1.000 558 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(3), CD2(2), CD3E(2), CD4(5), IFNG(2), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), JAK2(10), STAT4(3), TYK2(4) 4821447 46 29 46 23 6 18 3 15 4 0 0.920 1.000 1.000 559 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(8), ACO2(5), CS(2), GRHPR(2), HAO1(3), HAO2(3), HYI(2), MDH1(3), MTHFD1(3), MTHFD1L(6), MTHFD2(1) 4204956 38 28 37 18 14 15 1 4 4 0 0.707 1.000 1.000 560 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(8), ACO2(5), AFMID(1), CS(2), GRHPR(2), HAO1(3), HAO2(3), HYI(2), MDH1(3), MTHFD1(3), MTHFD1L(6), MTHFD2(1) 4403536 39 28 38 18 15 15 1 4 4 0 0.665 1.000 1.000 561 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(5), DLL1(10), FURIN(4), NOTCH1(20), PSEN1(2) 3009188 41 28 41 24 18 6 4 8 5 0 0.880 1.000 1.000 562 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(4), CBS(5), CTH(2), GGT1(5), MARS(4), MARS2(1), MAT1A(2), MAT2B(2), PAPSS1(4), PAPSS2(4), SCLY(1), SEPHS1(4) 4058004 38 28 37 24 13 9 2 7 7 0 0.948 1.000 1.000 563 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(3), CAMK1(2), CAMK1G(3), CAMK2A(3), CAMK2B(2), CAMK2D(1), CAMK2G(6), CAMK4(6), CAMKK1(5), CAMKK2(1), CREB1(3), SYT1(3) 3782577 39 27 39 18 12 17 2 6 2 0 0.638 1.000 1.000 564 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 ARF1(4), CCND1(1), CDK2(3), CDKN1A(1), CDKN2A(8), CFL1(1), E2F1(2), E2F2(3), MDM2(3), NXT1(2), PRB1(2) 2488524 30 27 30 11 10 10 1 2 7 0 0.586 1.000 1.000 565 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(2), HLA-DRA(6), IFNG(2), IFNGR1(5), IFNGR2(1), IL12A(2), IL12B(1), IL12RB1(4), IL12RB2(8), IL18(1), IL18R1(2), IL2RA(2), IL4(1), IL4R(1) 4164756 38 27 38 19 11 11 2 11 3 0 0.804 1.000 1.000 566 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(9), CHAT(4), CHKA(1), PCYT1A(6), PDHA1(1), PDHA2(4), PEMT(1), SLC18A3(7) 2278795 33 26 33 22 12 8 0 10 3 0 0.965 1.000 1.000 567 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(2), FH(2), IDH2(1), MDH1(3), OGDH(7), SDHA(6), SUCLA2(4) 3094516 30 26 29 12 11 8 2 4 5 0 0.587 1.000 1.000 568 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(4), ICAM1(1), ITGAL(11), ITGAM(6), ITGB2(5), SELE(4), SELL(4) 3412762 35 26 35 22 15 7 1 8 4 0 0.964 1.000 1.000 569 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP1(1), RANBP2(31), RANGAP1(5) 2768597 38 26 37 18 4 15 2 14 3 0 0.834 1.000 1.000 570 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3) 2620083 36 25 36 16 9 11 0 10 6 0 0.761 1.000 1.000 571 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(5), ALDH1A3(5), ALDH1B1(6), ALDH2(3), ALDH3A1(4), ALDH3A2(7), ALDH9A1(3) 2620083 36 25 36 16 9 11 0 10 6 0 0.761 1.000 1.000 572 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 9 CD3E(2), GZMB(2), HLA-A(7), ICAM1(1), ITGAL(11), ITGB2(5), PRF1(1) 2784927 29 25 29 12 10 7 3 6 3 0 0.596 1.000 1.000 573 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(3), HDAC9(6), MEF2A(1), MEF2B(4), MEF2C(3), MEF2D(6), MYOD1(4), YWHAH(3) 2537458 32 25 31 15 14 6 3 6 3 0 0.717 1.000 1.000 574 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(5), GAD1(6), HDC(7), PNMT(8), TH(2), TPH1(3) 1973649 31 25 30 17 14 7 2 6 2 0 0.858 1.000 1.000 575 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), ADSS(4), IMPDH1(5), MTHFD2(1), POLB(2), POLD1(10), POLG(5), PRPS2(2), RRM1(5), SRM(1) 4085683 38 25 38 16 10 15 2 8 3 0 0.628 1.000 1.000 576 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(6), CAPN1(2), CAPNS1(2), CAPNS2(2), CDK5(2), CDK5R1(1), CSNK1A1(3), CSNK1D(2), GSK3B(4), MAPT(4), PPP2CA(3) 3022973 31 25 30 20 11 10 0 6 4 0 0.952 1.000 1.000 577 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(3), IL13RA2(6), IL4R(1), JAK1(6), JAK2(10), TYK2(4) 3442081 31 25 31 17 7 12 2 7 3 0 0.903 1.000 1.000 578 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(3), IL13RA2(6), IL4R(1), JAK1(6), JAK2(10), TYK2(4) 3442081 31 25 31 17 7 12 2 7 3 0 0.903 1.000 1.000 579 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(6), AGT(3), AGTR1(1), AGTR2(2), BDKRB2(3), KNG1(8), NOS3(5), REN(2) 3220717 30 24 30 15 11 7 2 6 4 0 0.759 1.000 1.000 580 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(2), CYP11A1(4), CYP11B1(7), CYP11B2(4), CYP17A1(3), CYP21A2(4), HSD11B1(2), HSD11B2(2), HSD3B1(1), HSD3B2(3) 3038945 37 24 37 15 13 12 2 9 1 0 0.527 1.000 1.000 581 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(9), EGF(8), EGFR(11), HGS(1), RAB5A(2), TF(6), TFRC(1) 4217844 38 24 38 23 11 9 1 13 3 1 0.968 1.000 1.000 582 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(2), CYP11A1(4), CYP11B1(7), CYP11B2(4), CYP17A1(3), CYP21A2(4), HSD11B1(2), HSD11B2(2), HSD3B1(1), HSD3B2(3) 3038945 37 24 37 15 13 12 2 9 1 0 0.527 1.000 1.000 583 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(3), IARS(9), LARS(4), LARS2(7), PDHA1(1), PDHA2(4), PDHB(3) 3295346 31 24 31 15 4 10 1 9 7 0 0.922 1.000 1.000 584 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(1), ARPC4(2), CDC42(1), PAK1(5), PDGFRA(11), PIK3R1(8), WASL(2) 3682867 37 23 37 19 5 17 1 5 9 0 0.904 1.000 1.000 585 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CDO1(1), CSAD(7), GAD1(6), GAD2(7), GGT1(5) 1885172 27 23 27 14 14 4 0 8 1 0 0.757 1.000 1.000 586 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(2), APAF1(5), BCL2(2), CASP3(2), CASP9(2), DAXX(9), FAS(3), FASLG(2), IL1A(2), MAPKAPK2(1), MAPKAPK3(4), TNF(1) 3718456 35 23 35 19 14 8 0 10 3 0 0.888 1.000 1.000 587 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(3), CYR61(1), DUSP14(2), EIF4E(2), EIF4EBP1(2), HBEGF(2), IFNG(2), IFRD1(3), IL18(1), IL1A(2), IL1R1(4), JUND(1), MYOG(1), NR4A3(4) 3499349 32 23 32 14 13 4 4 9 2 0 0.655 1.000 1.000 588 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(3), GNGT1(3), HTR2C(5), PLCB1(13), TUB(5) 2350041 31 23 30 12 9 7 0 9 6 0 0.666 1.000 1.000 589 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IFNG(2), IL10(2), IL12A(2), IL12B(1), IL13(1), IL16(5), IL18(1), IL1A(2), IL3(1), IL4(1), IL8(1), LTA(3), TNF(1) 3263335 26 22 26 17 5 9 2 9 1 0 0.950 1.000 1.000 590 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(4), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(1), ST8SIA1(4) 1855029 23 22 23 11 12 4 0 7 0 0 0.677 1.000 1.000 591 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS1(1), DHRS2(1), DHRS3(2), DHRS7(3), DHRSX(5), HSD3B7(4), PON1(2), PON2(3), PON3(1), RDH11(1), RDH12(1), RDH13(3) 2954173 29 22 29 15 10 9 1 8 1 0 0.816 1.000 1.000 592 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(3), CASP8(8), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(2), TRADD(2), TRAF2(2) 2731630 23 22 23 11 6 3 1 9 4 0 0.816 1.000 1.000 593 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(5), TAX1BP3(2), UBE2A(1), UBE2D3(2), UBE2E3(3), UBE2G2(1), UBE2H(1), UBE2I(1), UBE2J1(1), UBE2J2(3), UBE2L3(1), UBE2L6(1), UBE2N(2), UBE3A(5) 3450536 31 22 31 16 14 9 0 4 4 0 0.770 1.000 1.000 594 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), CDK5R1(1), EGR1(4), MAP2K1(5), MAP2K2(2), MAPK1(2), MAPK3(1), NGFR(4), RAF1(7) 2674709 28 21 25 17 10 9 0 9 0 0 0.880 1.000 1.000 595 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(6), FARSA(1), FARSB(1), GOT1(2), GOT2(2), PAH(4), TAT(4), YARS(3), YARS2(3) 2858620 26 21 26 11 9 10 0 7 0 0 0.692 1.000 1.000 596 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(5), IFNGR2(1), JAK1(6), JAK2(10), STAT1(7) 2699309 31 21 31 13 5 12 2 8 4 0 0.699 1.000 1.000 597 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(4), LTB4R(1), P2RY1(3), P2RY2(5), P2RY6(6) 1954313 25 21 25 10 15 3 0 5 2 0 0.429 1.000 1.000 598 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP2(3), MMP9(13), RECK(5), TIMP2(2), TIMP3(3) 2468477 26 21 26 15 13 6 0 3 4 0 0.772 1.000 1.000 599 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(2), ACP5(1), ACPP(2), ACPT(4), ENPP1(5), ENPP3(4), FLAD1(3), RFK(1), TYR(6) 3183031 28 21 28 11 5 9 2 8 4 0 0.574 1.000 1.000 600 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(6), EIF4E(2), FBL(4), GPT(1), LDHA(3), LDHB(4), LDHC(1), MAPK14(1), NCL(6) 2939806 28 21 28 11 6 8 0 10 4 0 0.739 1.000 1.000 601 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(5), CLOCK(3), CRY1(3), CRY2(4), CSNK1E(7), PER1(5) 2776707 27 20 27 12 8 6 1 7 5 0 0.854 1.000 1.000 602 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(3), B3GALT2(6), B3GALT5(1), B3GNT5(3), FUT1(2), FUT3(1), ST3GAL3(1), ST3GAL4(4) 2365956 22 20 22 12 12 4 0 4 2 0 0.846 1.000 1.000 603 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(6), HADH(3), HADHA(4), HSD17B4(4), NTAN1(3), SIRT1(4), SIRT2(1), SIRT5(3), SIRT7(3), VNN2(2) 3894410 34 20 33 12 8 7 4 5 10 0 0.496 1.000 1.000 604 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(6), BMPR1A(3), BMPR1B(4), BMPR2(11) 2056897 24 20 24 10 8 6 1 2 5 2 0.694 1.000 1.000 605 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(3), MAX(3), MYC(3), SP1(6), SP3(3), WT1(3) 2043527 21 19 21 10 6 8 0 4 3 0 0.688 1.000 1.000 606 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(4), CYP11A1(4), CYP11B2(4), CYP17A1(3), HSD11B1(2), HSD11B2(2), HSD3B1(1), HSD3B2(3) 2272066 23 17 23 11 7 4 3 8 1 0 0.736 1.000 1.000 607 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), CS(2), MDH1(3), ME1(1), PC(7), PDHA1(1), SLC25A1(1), SLC25A11(1) 3040165 20 15 19 13 9 5 2 2 2 0 0.922 1.000 1.000 608 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(4), PLCD1(4), PRKCA(3), TGM2(5) 1632404 16 15 16 9 12 2 0 2 0 0 0.754 1.000 1.000 609 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(3), HSD3B7(4), RDH11(1), RDH12(1), RDH13(3) 1574645 14 14 14 9 4 6 0 4 0 0 0.868 1.000 1.000 610 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(2), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(1), ARPC4(2), CDC42(1), WASF1(3), WASL(2) 2671379 18 13 18 20 5 6 1 3 3 0 1.000 1.000 1.000 611 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(4), COQ6(2), COQ7(2), NDUFA13(3) 1309381 12 11 12 6 4 5 1 2 0 0 0.772 1.000 1.000 612 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(3), ALDH1A2(5), BCMO1(1), RDH5(2) 1281198 11 10 11 14 4 2 0 4 1 0 0.999 1.000 1.000 613 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(2), RAB11A(4), RAB27A(4), RAB4A(1), RAB5A(2), RAB6A(1) 1396343 14 9 14 12 5 6 0 2 1 0 0.947 1.000 1.000 614 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(2), FUT3(1), FUT5(2), FUT6(2), ST3GAL3(1) 1666837 9 8 9 7 6 2 0 1 0 0 0.879 1.000 1.000 615 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(7) 665732 7 5 7 4 2 2 0 3 0 0 0.888 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 167479 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000