Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.069 0.274 -9999.0 0.0 -0.797 29.0 29.0 IHH -0.068 0.202 -9999.0 0.0 -0.561 38.0 38.0 SHH Np/Cholesterol/GAS1 -0.035 0.127 -9999.0 0.0 -0.591 4.0 4.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.035 0.126 0.586 4.0 -9999.0 0.0 4.0 SMO/beta Arrestin2 -0.039 0.179 -9999.0 0.0 -0.613 12.0 12.0 SMO -0.046 0.189 -9999.0 0.0 -0.56 20.0 20.0 AKT1 -0.002 0.088 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.011 0.109 -9999.0 0.0 -0.536 11.0 11.0 ADRBK1 0.008 0.052 -9999.0 0.0 -0.842 1.0 1.0 heart looping -0.045 0.186 -9999.0 0.0 -0.55 20.0 20.0 STIL -0.121 0.248 -9999.0 0.0 -0.531 62.0 62.0 DHH N/PTCH2 -0.061 0.208 -9999.0 0.0 -0.592 35.0 35.0 DHH N/PTCH1 -0.035 0.158 -9999.0 0.0 -0.581 10.0 10.0 PIK3CA 0.008 0.052 -9999.0 0.0 -0.842 1.0 1.0 DHH 0.002 0.069 -9999.0 0.0 -0.505 5.0 5.0 PTHLH -0.072 0.273 -9999.0 0.0 -0.748 30.0 30.0 determination of left/right symmetry -0.045 0.186 -9999.0 0.0 -0.55 20.0 20.0 PIK3R1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.071 0.27 -9999.0 0.0 -0.739 30.0 30.0 IHH N/Hhip -0.126 0.235 -9999.0 0.0 -0.49 73.0 73.0 DHH N/Hhip -0.083 0.17 -9999.0 0.0 -0.365 71.0 71.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.045 0.186 -9999.0 0.0 -0.55 20.0 20.0 pancreas development -0.117 0.223 -9999.0 0.0 -0.504 68.0 68.0 HHAT 0.008 0.044 -9999.0 0.0 -0.505 2.0 2.0 PI3K 0.014 0.04 -9999.0 0.0 -0.651 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.033 0.149 -9999.0 0.0 -0.52 23.0 23.0 somite specification -0.045 0.186 -9999.0 0.0 -0.55 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.048 0.171 -9999.0 0.0 -0.53 18.0 18.0 SHH Np/Cholesterol/PTCH2 -0.068 0.186 -9999.0 0.0 -0.533 31.0 31.0 SHH Np/Cholesterol/Megalin -0.099 0.212 -9999.0 0.0 -0.536 45.0 45.0 SHH -0.021 0.123 -9999.0 0.0 -0.379 28.0 28.0 catabolic process -0.04 0.172 -9999.0 0.0 -0.627 10.0 10.0 SMO/Vitamin D3 -0.049 0.185 -9999.0 0.0 -0.543 21.0 21.0 SHH Np/Cholesterol/Hhip -0.081 0.171 -9999.0 0.0 -0.547 17.0 17.0 LRP2 -0.127 0.31 -9999.0 0.0 -0.82 45.0 45.0 receptor-mediated endocytosis -0.124 0.192 -9999.0 0.0 -0.554 31.0 31.0 SHH Np/Cholesterol/BOC -0.023 0.113 -9999.0 0.0 -0.528 4.0 4.0 SHH Np/Cholesterol/CDO -0.019 0.111 -9999.0 0.0 -0.525 5.0 5.0 mesenchymal cell differentiation 0.08 0.169 0.543 17.0 -9999.0 0.0 17.0 mol:Vitamin D3 -0.046 0.173 -9999.0 0.0 -0.533 18.0 18.0 IHH N/PTCH2 -0.107 0.243 -9999.0 0.0 -0.633 40.0 40.0 CDON -0.002 0.099 -9999.0 0.0 -0.708 5.0 5.0 IHH N/PTCH1 -0.041 0.174 -9999.0 0.0 -0.635 10.0 10.0 Megalin/LRPAP1 -0.091 0.242 -9999.0 0.0 -0.651 42.0 42.0 PTCH2 -0.08 0.261 -9999.0 0.0 -0.82 30.0 30.0 SHH Np/Cholesterol -0.03 0.091 -9999.0 0.0 -0.292 28.0 28.0 PTCH1 -0.041 0.173 -9999.0 0.0 -0.629 10.0 10.0 HHIP -0.117 0.223 -9999.0 0.0 -0.505 68.0 68.0