E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.001 0.081 -9999.0 0.0 -0.323 14.0 14.0 KLHL20 0.025 0.059 0.175 10.0 -0.185 3.0 13.0 CYFIP2 0.02 0.044 -9999.0 0.0 -0.336 4.0 4.0 Rac1/GDP 0.028 0.074 0.247 6.0 -0.233 5.0 11.0 ENAH 0.004 0.079 -9999.0 0.0 -0.329 13.0 13.0 AP1M1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.019 -9999.0 0.0 -0.268 1.0 1.0 CDC42/GTP 0.015 0.035 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.008 0.026 -9999.0 0.0 -0.135 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.049 -9999.0 0.0 -0.192 7.0 7.0 RAPGEF1 0.009 0.088 0.228 1.0 -0.314 10.0 11.0 CTNND1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.008 0.089 -9999.0 0.0 -0.327 17.0 17.0 CRK -0.002 0.072 -9999.0 0.0 -0.34 9.0 9.0 E-cadherin/gamma catenin/alpha catenin 0.04 0.048 -9999.0 0.0 -0.243 6.0 6.0 alphaE/beta7 Integrin 0.035 0.021 -9999.0 0.0 -0.252 1.0 1.0 IQGAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.046 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.001 0.081 -9999.0 0.0 -0.322 14.0 14.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.013 0.02 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.03 0.022 -9999.0 0.0 -0.152 3.0 3.0 PI3K 0.004 0.029 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.028 0.05 -9999.0 0.0 -0.286 6.0 6.0 TIAM1 0.022 0.035 -9999.0 0.0 -0.298 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.05 0.042 -9999.0 0.0 -0.182 6.0 6.0 AKT1 0.001 0.036 0.12 3.0 -9999.0 0.0 3.0 PIK3R1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.017 0.057 -9999.0 0.0 -0.358 6.0 6.0 RhoA/GDP 0.034 0.079 0.244 8.0 -0.229 5.0 13.0 actin cytoskeleton organization 0.023 0.049 0.15 13.0 -0.137 3.0 16.0 CDC42/GDP 0.034 0.08 0.244 8.0 -0.233 5.0 13.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.038 -9999.0 0.0 -0.224 6.0 6.0 ITGB7 0.025 0.024 -9999.0 0.0 -0.358 1.0 1.0 RAC1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.054 0.046 -9999.0 0.0 -0.195 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.037 0.037 -9999.0 0.0 -0.179 6.0 6.0 mol:GDP 0.022 0.086 0.249 8.0 -0.263 5.0 13.0 CDC42/GTP/IQGAP1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.03 -9999.0 0.0 -0.313 2.0 2.0 p120 catenin/RhoA/GDP 0.042 0.08 0.247 8.0 -0.235 5.0 13.0 RAC1/GTP/IQGAP1 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.038 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.017 0.035 0.121 10.0 -0.11 1.0 11.0 NME1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.004 0.08 -9999.0 0.0 -0.335 13.0 13.0 regulation of cell-cell adhesion 0.009 0.029 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.01 0.022 0.065 6.0 -9999.0 0.0 6.0 Rap1/GTP 0.03 0.057 0.165 24.0 -9999.0 0.0 24.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.055 -9999.0 0.0 -0.213 6.0 6.0 CCND1 0.02 0.041 0.143 9.0 -0.134 1.0 10.0 VAV2 0.018 0.118 -9999.0 0.0 -0.563 4.0 4.0 RAP1/GDP 0.042 0.074 0.225 13.0 -9999.0 0.0 13.0 adherens junction assembly 0.003 0.079 -9999.0 0.0 -0.325 13.0 13.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.046 0.055 -9999.0 0.0 -0.337 1.0 1.0 E-cadherin/beta catenin 0.003 0.045 -9999.0 0.0 -0.287 6.0 6.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.002 0.08 -9999.0 0.0 -0.329 13.0 13.0 PIK3CA 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.004 0.056 -9999.0 0.0 -0.267 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.042 0.044 -9999.0 0.0 -0.213 6.0 6.0 ITGAE 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.007 0.091 -9999.0 0.0 -0.333 17.0 17.0