Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.03 0.122 -9999.0 0.0 -0.452 11.0 11.0 IHH -0.031 0.148 -9999.0 0.0 -0.399 36.0 36.0 SHH Np/Cholesterol/GAS1 -0.01 0.08 -9999.0 0.0 -0.197 40.0 40.0 LRPAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.01 0.079 0.196 40.0 -9999.0 0.0 40.0 SMO/beta Arrestin2 -0.027 0.137 -9999.0 0.0 -0.395 18.0 18.0 SMO -0.038 0.132 -9999.0 0.0 -0.416 17.0 17.0 AKT1 -0.026 0.134 -9999.0 0.0 -0.468 16.0 16.0 ARRB2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.013 0.071 -9999.0 0.0 -0.349 10.0 10.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.036 0.131 -9999.0 0.0 -0.41 17.0 17.0 STIL -0.049 0.114 0.181 6.0 -0.309 27.0 33.0 DHH N/PTCH2 0.01 0.078 -9999.0 0.0 -0.196 33.0 33.0 DHH N/PTCH1 -0.012 0.108 -9999.0 0.0 -0.339 12.0 12.0 PIK3CA 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.019 0.052 -9999.0 0.0 -0.358 5.0 5.0 PTHLH -0.045 0.159 -9999.0 0.0 -0.579 13.0 13.0 determination of left/right symmetry -0.036 0.131 -9999.0 0.0 -0.41 17.0 17.0 PIK3R1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.045 0.158 -9999.0 0.0 -0.575 13.0 13.0 IHH N/Hhip -0.063 0.168 -9999.0 0.0 -0.327 73.0 73.0 DHH N/Hhip -0.033 0.127 -9999.0 0.0 -0.258 64.0 64.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.036 0.131 -9999.0 0.0 -0.41 17.0 17.0 pancreas development -0.061 0.16 -9999.0 0.0 -0.358 61.0 61.0 HHAT 0.023 0.033 -9999.0 0.0 -0.358 2.0 2.0 PI3K 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.004 0.102 -9999.0 0.0 -0.354 21.0 21.0 somite specification -0.036 0.131 -9999.0 0.0 -0.41 17.0 17.0 SHH Np/Cholesterol/PTCH1 -0.029 0.105 -9999.0 0.0 -0.327 16.0 16.0 SHH Np/Cholesterol/PTCH2 -0.014 0.078 -9999.0 0.0 -0.17 51.0 51.0 SHH Np/Cholesterol/Megalin -0.02 0.084 -9999.0 0.0 -0.168 60.0 60.0 SHH -0.014 0.079 -9999.0 0.0 -0.258 25.0 25.0 catabolic process -0.024 0.109 -9999.0 0.0 -0.363 12.0 12.0 SMO/Vitamin D3 -0.036 0.123 -9999.0 0.0 -0.382 16.0 16.0 SHH Np/Cholesterol/Hhip -0.041 0.116 -9999.0 0.0 -0.227 69.0 69.0 LRP2 -0.024 0.112 -9999.0 0.0 -0.274 45.0 45.0 receptor-mediated endocytosis -0.052 0.125 -9999.0 0.0 -0.365 22.0 22.0 SHH Np/Cholesterol/BOC -0.003 0.073 -9999.0 0.0 -0.198 32.0 32.0 SHH Np/Cholesterol/CDO -0.0 0.067 -9999.0 0.0 -0.191 28.0 28.0 mesenchymal cell differentiation 0.041 0.115 0.226 69.0 -9999.0 0.0 69.0 mol:Vitamin D3 -0.026 0.11 0.195 7.0 -0.335 15.0 22.0 IHH N/PTCH2 -0.025 0.114 -9999.0 0.0 -0.226 62.0 62.0 CDON 0.019 0.045 -9999.0 0.0 -0.304 5.0 5.0 IHH N/PTCH1 -0.017 0.113 -9999.0 0.0 -0.366 12.0 12.0 Megalin/LRPAP1 0.001 0.084 -9999.0 0.0 -0.188 44.0 44.0 PTCH2 -0.004 0.091 -9999.0 0.0 -0.271 28.0 28.0 SHH Np/Cholesterol -0.005 0.061 -9999.0 0.0 -0.193 25.0 25.0 PTCH1 -0.024 0.11 -9999.0 0.0 -0.364 12.0 12.0 HHIP -0.061 0.16 -9999.0 0.0 -0.358 61.0 61.0