Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.016 0.033 -9999.0 0.0 -0.189 6.0 6.0 epithelial cell differentiation 0.045 0.041 -9999.0 0.0 -0.181 6.0 6.0 CYFIP2 0.02 0.044 -9999.0 0.0 -0.336 4.0 4.0 ENAH -0.01 0.058 0.256 5.0 -0.228 1.0 6.0 EGFR 0.017 0.052 -9999.0 0.0 -0.358 5.0 5.0 EPHA2 0.022 0.035 -9999.0 0.0 -0.298 3.0 3.0 MYO6 -0.009 0.046 0.176 11.0 -9999.0 0.0 11.0 CTNNB1 0.025 0.019 -9999.0 0.0 -0.268 1.0 1.0 ABI1/Sra1/Nap1 0.044 0.035 -9999.0 0.0 -0.198 4.0 4.0 AQP5 -0.12 0.187 -9999.0 0.0 -0.398 78.0 78.0 CTNND1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.01 0.044 0.173 10.0 -9999.0 0.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.011 0.047 0.173 10.0 -0.282 1.0 11.0 EGF -0.032 0.127 -9999.0 0.0 -0.309 46.0 46.0 NCKAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.002 0.069 -9999.0 0.0 -0.352 7.0 7.0 cortical microtubule organization 0.045 0.041 -9999.0 0.0 -0.181 6.0 6.0 GO:0000145 -0.01 0.041 0.161 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.05 0.042 -9999.0 0.0 -0.182 6.0 6.0 MLLT4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.024 0.029 -9999.0 0.0 -0.305 1.0 1.0 ARF6 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.058 0.033 -9999.0 0.0 -0.195 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.039 0.171 8.0 -9999.0 0.0 8.0 PVRL2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.009 0.046 0.176 11.0 -9999.0 0.0 11.0 ARF6/GTP 0.061 0.037 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.017 0.057 -9999.0 0.0 -0.358 6.0 6.0 EGFR/EGFR/EGF/EGF 0.002 0.081 -9999.0 0.0 -0.252 2.0 2.0 RhoA/GDP 0.046 0.04 -9999.0 0.0 -0.171 6.0 6.0 actin cytoskeleton organization -0.011 0.042 0.162 10.0 -9999.0 0.0 10.0 IGF-1R heterotetramer 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.015 0.111 -9999.0 0.0 -0.305 34.0 34.0 DIAPH1 0.005 0.157 -9999.0 0.0 -0.535 10.0 10.0 Wnt receptor signaling pathway -0.045 0.041 0.181 6.0 -9999.0 0.0 6.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.025 0.028 -9999.0 0.0 -0.288 1.0 1.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.011 0.043 0.163 10.0 -9999.0 0.0 10.0 EFNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.015 0.044 0.168 8.0 -0.234 1.0 9.0 Ephrin A1/EPHA2 0.037 0.043 -9999.0 0.0 -0.326 1.0 1.0 SEC6/SEC8 -0.021 0.025 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.011 0.048 0.174 10.0 -0.286 1.0 11.0 HGF/MET 0.025 0.058 -9999.0 0.0 -0.174 7.0 7.0 HGF 0.022 0.031 -9999.0 0.0 -0.268 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.016 0.034 -9999.0 0.0 -0.19 6.0 6.0 actin cable formation 0.012 0.084 0.272 12.0 -0.349 1.0 13.0 KIAA1543 -0.009 0.043 0.164 11.0 -9999.0 0.0 11.0 KIFC3 -0.012 0.042 0.175 8.0 -9999.0 0.0 8.0 NCK1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.01 0.047 0.176 11.0 -9999.0 0.0 11.0 NCK1/GIT1 0.038 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.045 0.041 -9999.0 0.0 -0.181 6.0 6.0 EXOC4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.01 0.043 0.176 9.0 -9999.0 0.0 9.0 PIP5K1C -0.01 0.045 0.174 10.0 -9999.0 0.0 10.0 LIMA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.005 0.072 0.332 5.0 -0.26 1.0 6.0 adherens junction assembly -0.015 0.092 0.253 3.0 -0.541 4.0 7.0 IGF-1R heterotetramer/IGF1 0.018 0.07 -9999.0 0.0 -0.28 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.006 0.073 -9999.0 0.0 -0.273 17.0 17.0 PLEKHA7 -0.009 0.046 0.176 11.0 -9999.0 0.0 11.0 mol:GTP 0.056 0.033 -9999.0 0.0 -0.194 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.009 0.082 0.284 8.0 -9999.0 0.0 8.0 cortical actin cytoskeleton stabilization 0.016 0.033 -9999.0 0.0 -0.189 6.0 6.0 regulation of cell-cell adhesion -0.011 0.042 0.162 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.016 0.034 -9999.0 0.0 -0.19 6.0 6.0