Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	53.0	2439.0	46.0	-0.661	0.03	1000.0	-1000.0	-0.143	-1000.0
Signaling events regulated by Ret tyrosine kinase	37.0	3091.0	82.0	-0.105	0.027	1000.0	-1000.0	-0.054	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	35.0	1937.0	54.0	-0.104	0.037	1000.0	-1000.0	-0.037	-1000.0
Effects of Botulinum toxin	35.0	924.0	26.0	-0.105	0.026	1000.0	-1000.0	-0.005	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	34.0	1184.0	34.0	-0.061	0.027	1000.0	-1000.0	-0.029	-1000.0
p75(NTR)-mediated signaling	34.0	4335.0	125.0	-0.127	0.068	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	33.0	2639.0	78.0	-0.212	0.065	1000.0	-1000.0	-0.047	-1000.0
Aurora C signaling	31.0	217.0	7.0	-0.338	0.041	1000.0	-1000.0	-0.013	-1000.0
Wnt signaling	31.0	219.0	7.0	-0.062	0.023	1000.0	-1000.0	-0.017	-1000.0
IL4-mediated signaling events	30.0	2775.0	91.0	-0.632	0.495	1000.0	-1000.0	-0.168	-1000.0
Reelin signaling pathway	28.0	1622.0	56.0	-0.087	0.06	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by the Hedgehog family	25.0	1302.0	52.0	-0.063	0.041	1000.0	-1000.0	-0.043	-1000.0
Syndecan-2-mediated signaling events	24.0	1676.0	69.0	-0.119	0.042	1000.0	-1000.0	-0.04	-1000.0
Fc-epsilon receptor I signaling in mast cells	24.0	2383.0	97.0	-0.089	0.042	1000.0	-1000.0	-0.059	-1000.0
Noncanonical Wnt signaling pathway	23.0	611.0	26.0	-0.063	0.026	1000.0	-1000.0	-0.041	-1000.0
Glypican 1 network	22.0	1071.0	48.0	-0.081	0.046	1000.0	-1000.0	-0.029	-1000.0
Ephrin A  reverse signaling	21.0	151.0	7.0	-0.012	0.008	1000.0	-1000.0	-0.011	-1000.0
BMP receptor signaling	21.0	1738.0	81.0	-0.183	0.047	1000.0	-1000.0	-0.049	-1000.0
Ephrin B reverse signaling	21.0	1030.0	48.0	-0.119	0.061	1000.0	-1000.0	-0.024	-1000.0
Canonical Wnt signaling pathway	21.0	1094.0	51.0	-0.109	0.107	1000.0	-1000.0	-0.045	-1000.0
EPHB forward signaling	20.0	1771.0	85.0	-0.119	0.095	1000.0	-1000.0	-0.057	-1000.0
BCR signaling pathway	20.0	2017.0	99.0	-0.131	0.033	1000.0	-1000.0	-0.05	-1000.0
IL23-mediated signaling events	19.0	1147.0	60.0	-0.557	0.033	1000.0	-1000.0	-0.142	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	18.0	943.0	52.0	-0.118	0.054	1000.0	-1000.0	-0.047	-1000.0
Presenilin action in Notch and Wnt signaling	17.0	1078.0	61.0	-0.109	0.068	1000.0	-1000.0	-0.044	-1000.0
Syndecan-1-mediated signaling events	16.0	547.0	34.0	-0.09	0.026	1000.0	-1000.0	-0.039	-1000.0
Glypican 2 network	16.0	64.0	4.0	0.005	0.018	1000.0	-1000.0	0.01	-1000.0
Visual signal transduction: Cones	15.0	604.0	38.0	-0.031	0.046	1000.0	-1000.0	-0.01	-1000.0
amb2 Integrin signaling	15.0	1258.0	82.0	-0.106	0.048	1000.0	-1000.0	-0.035	-1000.0
EGFR-dependent Endothelin signaling events	15.0	318.0	21.0	-0.036	0.038	1000.0	-1000.0	-0.039	-1000.0
Visual signal transduction: Rods	15.0	803.0	52.0	-0.05	0.034	1000.0	-1000.0	-0.022	-1000.0
HIF-1-alpha transcription factor network	14.0	1118.0	76.0	-0.239	0.035	1000.0	-1000.0	-0.138	-1000.0
Endothelins	14.0	1426.0	96.0	-0.199	0.029	1000.0	-1000.0	-0.062	-1000.0
TCGA08_p53	14.0	101.0	7.0	-0.035	0.026	1000.0	-1000.0	-0.004	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	14.0	1706.0	120.0	-0.084	0.069	1000.0	-1000.0	-0.041	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1259.0	93.0	-0.1	0.049	1000.0	-1000.0	-0.053	-1000.0
LPA receptor mediated events	13.0	1371.0	102.0	-0.091	0.037	1000.0	-1000.0	-0.057	-1000.0
TCGA08_retinoblastoma	13.0	108.0	8.0	-0.039	0.028	1000.0	-1000.0	-0.004	-1000.0
PDGFR-beta signaling pathway	12.0	1172.0	97.0	-0.063	0.068	1000.0	-1000.0	-0.053	-1000.0
Aurora B signaling	12.0	840.0	67.0	-0.257	0.087	1000.0	-1000.0	-0.037	-1000.0
ErbB2/ErbB3 signaling events	11.0	775.0	65.0	-0.064	0.038	1000.0	-1000.0	-0.054	-1000.0
Arf6 signaling events	11.0	685.0	62.0	-0.058	0.062	1000.0	-1000.0	-0.04	-1000.0
Nongenotropic Androgen signaling	11.0	590.0	52.0	-0.051	0.042	1000.0	-1000.0	-0.033	-1000.0
ErbB4 signaling events	10.0	730.0	69.0	-0.09	0.043	1000.0	-1000.0	-0.04	-1000.0
IL1-mediated signaling events	10.0	626.0	62.0	-0.045	0.068	1000.0	-1000.0	-0.045	-1000.0
IL27-mediated signaling events	10.0	524.0	51.0	-0.252	0.089	1000.0	-1000.0	-0.054	-1000.0
Syndecan-4-mediated signaling events	10.0	725.0	67.0	-0.136	0.032	1000.0	-1000.0	-0.036	-1000.0
Regulation of Androgen receptor activity	10.0	725.0	70.0	-0.179	0.032	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by PTP1B	9.0	721.0	76.0	-0.071	0.035	1000.0	-1000.0	-0.034	-1000.0
Nectin adhesion pathway	9.0	576.0	63.0	-0.181	0.049	1000.0	-1000.0	-0.061	-1000.0
S1P5 pathway	9.0	167.0	17.0	-0.028	0.029	1000.0	-1000.0	-0.016	-1000.0
FAS signaling pathway (CD95)	9.0	432.0	47.0	-0.024	0.038	1000.0	-1000.0	-0.045	-1000.0
Syndecan-3-mediated signaling events	9.0	340.0	35.0	-0.114	0.068	1000.0	-1000.0	-0.016	-1000.0
Integrins in angiogenesis	9.0	809.0	84.0	-0.111	0.061	1000.0	-1000.0	-0.043	-1000.0
Calcium signaling in the CD4+ TCR pathway	9.0	294.0	31.0	-0.105	0.026	1000.0	-1000.0	-0.041	-1000.0
Plasma membrane estrogen receptor signaling	9.0	856.0	86.0	-0.091	0.05	1000.0	-1000.0	-0.052	-1000.0
LPA4-mediated signaling events	8.0	98.0	12.0	-0.041	0.006	1000.0	-1000.0	-0.023	-1000.0
Osteopontin-mediated events	8.0	320.0	38.0	-0.109	0.041	1000.0	-1000.0	-0.046	-1000.0
Cellular roles of Anthrax toxin	8.0	346.0	39.0	-0.017	0.026	1000.0	-1000.0	-0.02	-1000.0
Glucocorticoid receptor regulatory network	8.0	998.0	114.0	-0.214	0.128	1000.0	-1000.0	-0.064	-1000.0
Ceramide signaling pathway	8.0	679.0	76.0	-0.032	0.069	1000.0	-1000.0	-0.04	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	8.0	302.0	37.0	-0.086	0.061	1000.0	-1000.0	-0.032	-1000.0
ceramide signaling pathway	8.0	402.0	49.0	-0.0	0.039	1000.0	-1000.0	-0.042	-1000.0
S1P4 pathway	8.0	212.0	25.0	-0.028	0.045	1000.0	-1000.0	-0.027	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	7.0	625.0	85.0	-0.034	0.043	1000.0	-1000.0	-0.043	-1000.0
EPO signaling pathway	7.0	416.0	55.0	0.003	0.053	1000.0	-1000.0	-0.037	-1000.0
PLK1 signaling events	7.0	644.0	85.0	-0.006	0.048	1000.0	-1000.0	-0.032	-1000.0
PDGFR-alpha signaling pathway	7.0	319.0	44.0	-0.081	0.072	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	7.0	283.0	36.0	-0.041	0.026	1000.0	-1000.0	-0.045	-1000.0
IGF1 pathway	7.0	437.0	57.0	-0.025	0.05	1000.0	-1000.0	-0.043	-1000.0
Caspase cascade in apoptosis	6.0	452.0	74.0	-0.04	0.063	1000.0	-1000.0	-0.035	-1000.0
IFN-gamma pathway	6.0	449.0	68.0	-0.051	0.038	1000.0	-1000.0	-0.05	-1000.0
Class I PI3K signaling events mediated by Akt	6.0	468.0	68.0	-0.029	0.045	1000.0	-1000.0	-0.037	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	504.0	74.0	-0.12	0.061	1000.0	-1000.0	-0.068	-1000.0
Class I PI3K signaling events	6.0	481.0	73.0	-0.043	0.046	1000.0	-1000.0	-0.041	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	201.0	33.0	-0.041	0.062	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling in keratinocytes	6.0	267.0	43.0	-0.026	0.042	1000.0	-1000.0	-0.031	-1000.0
Coregulation of Androgen receptor activity	5.0	431.0	76.0	-0.059	0.051	1000.0	-1000.0	-0.028	-1000.0
IL12-mediated signaling events	5.0	455.0	87.0	-0.054	0.042	1000.0	-1000.0	-0.095	-1000.0
Retinoic acid receptors-mediated signaling	5.0	312.0	58.0	-0.123	0.05	1000.0	-1000.0	-0.052	-1000.0
IL2 signaling events mediated by PI3K	5.0	309.0	58.0	-0.024	0.046	1000.0	-1000.0	-0.051	-1000.0
Regulation of p38-alpha and p38-beta	5.0	318.0	54.0	-0.043	0.057	1000.0	-1000.0	-0.045	-1000.0
IL6-mediated signaling events	5.0	384.0	75.0	-0.169	0.041	1000.0	-1000.0	-0.072	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	377.0	68.0	-0.167	0.027	1000.0	-1000.0	-0.09	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	388.0	76.0	-0.013	0.057	1000.0	-1000.0	-0.05	-1000.0
S1P3 pathway	5.0	250.0	42.0	-0.027	0.046	1000.0	-1000.0	-0.032	-1000.0
Angiopoietin receptor Tie2-mediated signaling	5.0	450.0	88.0	-0.073	0.065	1000.0	-1000.0	-0.065	-1000.0
FOXM1 transcription factor network	5.0	276.0	51.0	-0.053	0.037	1000.0	-1000.0	-0.169	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	88.0	17.0	-0.0	0.041	1000.0	-1000.0	-0.028	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	126.0	28.0	-0.028	0.043	1000.0	-1000.0	-0.02	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	0.006	0.022	1000.0	-1000.0	-0.01	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	79.0	17.0	-0.019	0.062	1000.0	-1000.0	-0.038	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	405.0	83.0	-0.086	0.051	1000.0	-1000.0	-0.033	-1000.0
FoxO family signaling	4.0	312.0	64.0	-0.098	0.051	1000.0	-1000.0	-0.074	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	184.0	45.0	-0.001	0.067	1000.0	-1000.0	-0.05	-1000.0
Regulation of Telomerase	4.0	507.0	102.0	-0.114	0.061	1000.0	-1000.0	-0.059	-1000.0
E-cadherin signaling events	4.0	23.0	5.0	0.017	0.039	1000.0	-1000.0	0.009	-1000.0
p38 MAPK signaling pathway	4.0	198.0	44.0	-0.051	0.055	1000.0	-1000.0	-0.03	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	439.0	136.0	-0.062	0.068	1000.0	-1000.0	-0.049	-1000.0
Thromboxane A2 receptor signaling	3.0	405.0	105.0	-0.032	0.043	1000.0	-1000.0	-0.043	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	253.0	65.0	-0.058	0.059	1000.0	-1000.0	-0.052	-1000.0
Aurora A signaling	3.0	203.0	60.0	-0.036	0.052	1000.0	-1000.0	-0.02	-1000.0
Arf6 downstream pathway	3.0	135.0	43.0	-0.029	0.045	1000.0	-1000.0	-0.019	-1000.0
mTOR signaling pathway	3.0	209.0	53.0	-0.035	0.035	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	54.0	15.0	-0.022	0.026	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	165.0	44.0	-0.037	0.027	1000.0	-1000.0	-0.028	-1000.0
TCGA08_rtk_signaling	3.0	96.0	26.0	-0.037	0.073	1000.0	-1000.0	-0.021	-1000.0
Arf6 trafficking events	3.0	228.0	71.0	-0.046	0.048	1000.0	-1000.0	-0.032	-1000.0
Insulin Pathway	3.0	255.0	74.0	-0.018	0.064	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by PRL	3.0	114.0	34.0	-0.038	0.038	1000.0	-1000.0	-0.047	-1000.0
Canonical NF-kappaB pathway	2.0	104.0	39.0	-0.005	0.055	1000.0	-1000.0	-0.038	-1000.0
Insulin-mediated glucose transport	2.0	84.0	32.0	-0.042	0.049	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class III	2.0	97.0	40.0	-0.047	0.049	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	288.0	125.0	-0.005	0.065	1000.0	-1000.0	-0.048	-1000.0
IL2 signaling events mediated by STAT5	2.0	50.0	22.0	-0.0	0.031	1000.0	-1000.0	-0.046	-1000.0
VEGFR1 specific signals	2.0	160.0	56.0	-0.015	0.058	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by HDAC Class II	1.0	90.0	75.0	-0.026	0.068	1000.0	-1000.0	-0.028	-1000.0
TRAIL signaling pathway	1.0	50.0	48.0	-0.0	0.056	1000.0	-1000.0	-0.03	-1000.0
HIF-2-alpha transcription factor network	1.0	45.0	43.0	-0.056	0.057	1000.0	-1000.0	-0.074	-1000.0
Signaling events mediated by HDAC Class I	1.0	155.0	104.0	-0.051	0.063	1000.0	-1000.0	-0.032	-1000.0
Rapid glucocorticoid signaling	1.0	31.0	20.0	-0.009	0.033	1000.0	-1000.0	-0.005	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.025	0.025	1000.0	-1000.0	-0.011	-1000.0
Arf1 pathway	1.0	54.0	54.0	-0.001	0.048	1000.0	-1000.0	-0.019	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	13.0	23.0	0.009	0.045	1000.0	-1000.0	-0.028	-1000.0
BARD1 signaling events	0.0	52.0	57.0	-0.056	0.065	1000.0	-1000.0	-0.047	-1000.0
Circadian rhythm pathway	0.0	15.0	22.0	-0.006	0.059	1000.0	-1000.0	-0.046	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	2.0	5.0	0.025	0.037	1000.0	-1000.0	0.01	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	27.0	36.0	-0.049	0.051	1000.0	-1000.0	-0.039	-1000.0
Atypical NF-kappaB pathway	0.0	20.0	31.0	-0.0	0.035	1000.0	-1000.0	-0.023	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	19.0	27.0	-0.011	0.056	1000.0	-1000.0	-0.034	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.07	1000.0	-1000.0	-0.0	-1000.0
Total	1342	80366	7203	-10.4378489917	6.73123453534	131000	-131000	-5.50017695197	-131000