This pipeline computes the correlation between significant arm-level copy number variations (cnvs) and selected clinical features.
Testing the association between copy number variation 55 arm-level events and 15 clinical features across 475 patients, 57 significant findings detected with Q value < 0.25.
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1Q GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.T.STAGE', and 'EXTRATHYROIDAL.EXTENSION'.
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4P GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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4Q GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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5P GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE'.
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5Q GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.M.STAGE', and 'NUMBER.OF.LYMPH.NODES'.
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7P GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE' and 'NUMBER.OF.LYMPH.NODES'.
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7Q GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE' and 'NUMBER.OF.LYMPH.NODES'.
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8Q GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE'.
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9Q GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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11P GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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11Q GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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12P GAIN MUTATION ANALYSIS cnv correlated to 'PATHOLOGY.M.STAGE' and 'NUMBER.OF.LYMPH.NODES'.
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12Q GAIN MUTATION ANALYSIS cnv correlated to 'PATHOLOGY.M.STAGE' and 'NUMBER.OF.LYMPH.NODES'.
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13Q GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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16P GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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16Q GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE' and 'NUMBER.OF.LYMPH.NODES'.
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17P GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE' and 'NUMBER.OF.LYMPH.NODES'.
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17Q GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE' and 'NUMBER.OF.LYMPH.NODES'.
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18P GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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18Q GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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19P GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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19Q GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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20P GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.M.STAGE', and 'NUMBER.OF.LYMPH.NODES'.
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20Q GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.M.STAGE', and 'NUMBER.OF.LYMPH.NODES'.
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21Q GAIN MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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XQ GAIN MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE'.
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2P LOSS MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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2Q LOSS MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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3Q LOSS MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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6Q LOSS MUTATION ANALYSIS cnv correlated to 'Time to Death'.
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8P LOSS MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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8Q LOSS MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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9Q LOSS MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE'.
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10P LOSS MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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10Q LOSS MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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11P LOSS MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE'.
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11Q LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'NEOPLASM.DISEASESTAGE'.
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13Q LOSS MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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17Q LOSS MUTATION ANALYSIS cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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XQ LOSS MUTATION ANALYSIS cnv correlated to 'NEOPLASM.DISEASESTAGE' and 'NUMBER.OF.LYMPH.NODES'.
Clinical Features |
Time to Death |
AGE |
NEOPLASM DISEASESTAGE |
PATHOLOGY T STAGE |
PATHOLOGY N STAGE |
PATHOLOGY M STAGE |
GENDER |
HISTOLOGICAL TYPE |
RADIATIONS RADIATION REGIMENINDICATION |
RADIATIONEXPOSURE |
EXTRATHYROIDAL EXTENSION |
COMPLETENESS OF RESECTION |
NUMBER OF LYMPH NODES |
MULTIFOCALITY |
TUMOR SIZE |
||
nCNV (%) | nWild-Type | logrank test | t-test | Chi-square test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | t-test | Fisher's exact test | t-test | |
1Q GAIN MUTATION ANALYSIS | 23 (5%) | 452 |
0.147 (1.00) |
0.000629 (0.473) |
6.31e-06 (0.00491) |
0.000144 (0.11) |
0.00345 (1.00) |
0.68 (1.00) |
0.339 (1.00) |
0.0253 (1.00) |
0.506 (1.00) |
0.591 (1.00) |
0.000255 (0.193) |
0.0178 (1.00) |
0.548 (1.00) |
0.055 (1.00) |
0.0507 (1.00) |
5Q GAIN MUTATION ANALYSIS | 15 (3%) | 460 |
0.0194 (1.00) |
0.00985 (1.00) |
5.66e-05 (0.0436) |
0.633 (1.00) |
0.0107 (1.00) |
1.37e-05 (0.0106) |
0.555 (1.00) |
0.0309 (1.00) |
0.366 (1.00) |
1 (1.00) |
0.0356 (1.00) |
0.516 (1.00) |
3.57e-25 (2.9e-22) |
0.607 (1.00) |
0.147 (1.00) |
20P GAIN MUTATION ANALYSIS | 12 (3%) | 463 |
0.33 (1.00) |
0.0901 (1.00) |
5.85e-05 (0.045) |
0.496 (1.00) |
0.0678 (1.00) |
0.000173 (0.132) |
0.524 (1.00) |
0.00495 (1.00) |
1 (1.00) |
1 (1.00) |
0.0231 (1.00) |
0.846 (1.00) |
3.83e-25 (3.09e-22) |
0.779 (1.00) |
0.129 (1.00) |
20Q GAIN MUTATION ANALYSIS | 12 (3%) | 463 |
0.33 (1.00) |
0.0901 (1.00) |
5.85e-05 (0.045) |
0.496 (1.00) |
0.0678 (1.00) |
0.000173 (0.132) |
0.524 (1.00) |
0.00495 (1.00) |
1 (1.00) |
1 (1.00) |
0.0231 (1.00) |
0.846 (1.00) |
3.83e-25 (3.09e-22) |
0.779 (1.00) |
0.129 (1.00) |
7P GAIN MUTATION ANALYSIS | 16 (3%) | 459 |
0.353 (1.00) |
0.0414 (1.00) |
3.81e-05 (0.0295) |
0.844 (1.00) |
0.00569 (1.00) |
0.00183 (1.00) |
1 (1.00) |
0.0126 (1.00) |
1 (1.00) |
1 (1.00) |
0.0123 (1.00) |
0.516 (1.00) |
3.49e-25 (2.84e-22) |
0.802 (1.00) |
0.633 (1.00) |
7Q GAIN MUTATION ANALYSIS | 18 (4%) | 457 |
0.368 (1.00) |
0.0284 (1.00) |
0.000208 (0.158) |
0.938 (1.00) |
0.00569 (1.00) |
0.0041 (1.00) |
0.792 (1.00) |
0.00881 (1.00) |
1 (1.00) |
1 (1.00) |
0.0278 (1.00) |
0.215 (1.00) |
3.49e-25 (2.84e-22) |
0.811 (1.00) |
0.583 (1.00) |
12P GAIN MUTATION ANALYSIS | 13 (3%) | 462 |
0.521 (1.00) |
0.154 (1.00) |
0.0302 (1.00) |
1 (1.00) |
0.00358 (1.00) |
9.15e-05 (0.0701) |
1 (1.00) |
0.011 (1.00) |
1 (1.00) |
1 (1.00) |
0.26 (1.00) |
0.276 (1.00) |
3.66e-25 (2.96e-22) |
0.586 (1.00) |
0.903 (1.00) |
12Q GAIN MUTATION ANALYSIS | 14 (3%) | 461 |
0.521 (1.00) |
0.129 (1.00) |
0.0527 (1.00) |
0.968 (1.00) |
0.00358 (1.00) |
4.78e-05 (0.0369) |
1 (1.00) |
0.00429 (1.00) |
1 (1.00) |
1 (1.00) |
0.237 (1.00) |
0.232 (1.00) |
3.66e-25 (2.96e-22) |
0.791 (1.00) |
0.903 (1.00) |
16Q GAIN MUTATION ANALYSIS | 12 (3%) | 463 |
0.202 (1.00) |
0.102 (1.00) |
7.51e-05 (0.0577) |
0.697 (1.00) |
0.0678 (1.00) |
0.00321 (1.00) |
1 (1.00) |
0.0266 (1.00) |
1 (1.00) |
1 (1.00) |
0.0231 (1.00) |
0.333 (1.00) |
3.83e-25 (3.09e-22) |
0.779 (1.00) |
0.663 (1.00) |
17P GAIN MUTATION ANALYSIS | 16 (3%) | 459 |
0.424 (1.00) |
0.0976 (1.00) |
3.81e-05 (0.0295) |
0.844 (1.00) |
0.036 (1.00) |
0.00838 (1.00) |
1 (1.00) |
0.0472 (1.00) |
1 (1.00) |
1 (1.00) |
0.76 (1.00) |
0.289 (1.00) |
1.44e-06 (0.00112) |
1 (1.00) |
0.399 (1.00) |
17Q GAIN MUTATION ANALYSIS | 17 (4%) | 458 |
0.424 (1.00) |
0.16 (1.00) |
0.000103 (0.0783) |
0.855 (1.00) |
0.0205 (1.00) |
0.00601 (1.00) |
1 (1.00) |
0.0765 (1.00) |
1 (1.00) |
1 (1.00) |
0.685 (1.00) |
0.319 (1.00) |
2.02e-07 (0.000158) |
0.806 (1.00) |
0.574 (1.00) |
11Q LOSS MUTATION ANALYSIS | 9 (2%) | 466 |
0.00379 (1.00) |
8.99e-05 (0.069) |
7.2e-06 (0.00559) |
0.188 (1.00) |
0.503 (1.00) |
0.145 (1.00) |
0.00169 (1.00) |
1 (1.00) |
0.238 (1.00) |
1 (1.00) |
0.793 (1.00) |
0.49 (1.00) |
0.252 (1.00) |
1 (1.00) |
0.0132 (1.00) |
XQ LOSS MUTATION ANALYSIS | 4 (1%) | 471 |
0.748 (1.00) |
0.0809 (1.00) |
1.57e-06 (0.00122) |
0.056 (1.00) |
0.123 (1.00) |
0.103 (1.00) |
0.0577 (1.00) |
1 (1.00) |
1 (1.00) |
0.117 (1.00) |
0.636 (1.00) |
0.298 (1.00) |
4.19e-25 (3.34e-22) |
1 (1.00) |
0.863 (1.00) |
4P GAIN MUTATION ANALYSIS | 5 (1%) | 470 |
0.0297 (1.00) |
0.0531 (1.00) |
0.372 (1.00) |
0.625 (1.00) |
0.061 (1.00) |
0.0444 (1.00) |
1 (1.00) |
0.192 (1.00) |
0.139 (1.00) |
1 (1.00) |
1 (1.00) |
0.371 (1.00) |
4.1e-25 (3.28e-22) |
0.185 (1.00) |
0.299 (1.00) |
4Q GAIN MUTATION ANALYSIS | 5 (1%) | 470 |
0.0297 (1.00) |
0.0531 (1.00) |
0.372 (1.00) |
0.625 (1.00) |
0.061 (1.00) |
0.0444 (1.00) |
1 (1.00) |
0.192 (1.00) |
0.139 (1.00) |
1 (1.00) |
1 (1.00) |
0.371 (1.00) |
4.1e-25 (3.28e-22) |
0.185 (1.00) |
0.299 (1.00) |
5P GAIN MUTATION ANALYSIS | 18 (4%) | 457 |
0.0737 (1.00) |
0.000897 (0.673) |
0.000238 (0.18) |
0.476 (1.00) |
0.172 (1.00) |
0.000347 (0.262) |
0.585 (1.00) |
0.0999 (1.00) |
0.422 (1.00) |
1 (1.00) |
0.0324 (1.00) |
0.533 (1.00) |
0.0121 (1.00) |
1 (1.00) |
0.102 (1.00) |
8Q GAIN MUTATION ANALYSIS | 7 (1%) | 468 |
0.0949 (1.00) |
0.362 (1.00) |
3.05e-06 (0.00237) |
0.397 (1.00) |
1 (1.00) |
0.0928 (1.00) |
0.682 (1.00) |
0.827 (1.00) |
1 (1.00) |
1 (1.00) |
0.00795 (1.00) |
0.362 (1.00) |
0.002 (1.00) |
0.13 (1.00) |
0.274 (1.00) |
9Q GAIN MUTATION ANALYSIS | 4 (1%) | 471 |
0.693 (1.00) |
0.0152 (1.00) |
0.0697 (1.00) |
0.623 (1.00) |
0.623 (1.00) |
1 (1.00) |
0.284 (1.00) |
0.472 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.000155 (0.118) |
0.338 (1.00) |
0.00973 (1.00) |
11P GAIN MUTATION ANALYSIS | 6 (1%) | 469 |
0.563 (1.00) |
0.791 (1.00) |
0.942 (1.00) |
0.692 (1.00) |
0.123 (1.00) |
0.182 (1.00) |
0.19 (1.00) |
0.263 (1.00) |
1 (1.00) |
1 (1.00) |
0.348 (1.00) |
0.44 (1.00) |
4.19e-25 (3.34e-22) |
0.225 (1.00) |
0.556 (1.00) |
11Q GAIN MUTATION ANALYSIS | 5 (1%) | 470 |
0.567 (1.00) |
0.82 (1.00) |
0.964 (1.00) |
0.794 (1.00) |
0.248 (1.00) |
0.245 (1.00) |
0.611 (1.00) |
0.579 (1.00) |
1 (1.00) |
1 (1.00) |
0.438 (1.00) |
0.371 (1.00) |
4.28e-25 (3.38e-22) |
0.0651 (1.00) |
0.822 (1.00) |
13Q GAIN MUTATION ANALYSIS | 5 (1%) | 470 |
0.726 (1.00) |
0.162 (1.00) |
0.0172 (1.00) |
0.699 (1.00) |
0.123 (1.00) |
0.245 (1.00) |
1 (1.00) |
0.192 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
4.19e-25 (3.34e-22) |
0.665 (1.00) |
0.65 (1.00) |
16P GAIN MUTATION ANALYSIS | 14 (3%) | 461 |
0.21 (1.00) |
0.151 (1.00) |
0.000536 (0.403) |
0.789 (1.00) |
0.0371 (1.00) |
0.00562 (1.00) |
1 (1.00) |
0.0899 (1.00) |
1 (1.00) |
1 (1.00) |
0.0376 (1.00) |
0.164 (1.00) |
3.74e-25 (3.02e-22) |
1 (1.00) |
0.674 (1.00) |
18P GAIN MUTATION ANALYSIS | 6 (1%) | 469 |
0.625 (1.00) |
0.727 (1.00) |
0.942 (1.00) |
0.692 (1.00) |
0.061 (1.00) |
0.471 (1.00) |
0.656 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.371 (1.00) |
4.19e-25 (3.34e-22) |
0.691 (1.00) |
0.605 (1.00) |
18Q GAIN MUTATION ANALYSIS | 6 (1%) | 469 |
0.625 (1.00) |
0.727 (1.00) |
0.942 (1.00) |
0.692 (1.00) |
0.061 (1.00) |
0.471 (1.00) |
0.656 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.371 (1.00) |
4.19e-25 (3.34e-22) |
0.691 (1.00) |
0.605 (1.00) |
19P GAIN MUTATION ANALYSIS | 8 (2%) | 467 |
0.728 (1.00) |
0.076 (1.00) |
0.881 (1.00) |
0.572 (1.00) |
0.0302 (1.00) |
0.00453 (1.00) |
0.216 (1.00) |
0.0097 (1.00) |
1 (1.00) |
1 (1.00) |
0.588 (1.00) |
0.429 (1.00) |
3.92e-25 (3.14e-22) |
0.151 (1.00) |
0.216 (1.00) |
19Q GAIN MUTATION ANALYSIS | 10 (2%) | 465 |
0.0385 (1.00) |
0.0268 (1.00) |
0.771 (1.00) |
0.33 (1.00) |
0.0149 (1.00) |
0.00094 (0.704) |
0.138 (1.00) |
0.00621 (1.00) |
0.261 (1.00) |
1 (1.00) |
0.507 (1.00) |
0.665 (1.00) |
3.83e-25 (3.09e-22) |
0.524 (1.00) |
0.142 (1.00) |
21Q GAIN MUTATION ANALYSIS | 5 (1%) | 470 |
0.625 (1.00) |
0.0455 (1.00) |
0.767 (1.00) |
0.552 (1.00) |
0.248 (1.00) |
0.688 (1.00) |
0.611 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.636 (1.00) |
0.298 (1.00) |
4.28e-25 (3.38e-22) |
0.0651 (1.00) |
0.318 (1.00) |
XQ GAIN MUTATION ANALYSIS | 8 (2%) | 467 |
0.302 (1.00) |
0.192 (1.00) |
8.88e-06 (0.00689) |
0.469 (1.00) |
0.685 (1.00) |
0.00453 (1.00) |
0.118 (1.00) |
0.261 (1.00) |
1 (1.00) |
1 (1.00) |
0.0273 (1.00) |
0.429 (1.00) |
0.964 (1.00) |
0.479 (1.00) |
0.21 (1.00) |
2P LOSS MUTATION ANALYSIS | 10 (2%) | 465 |
0.714 (1.00) |
0.272 (1.00) |
0.00327 (1.00) |
0.686 (1.00) |
0.00731 (1.00) |
0.0177 (1.00) |
0.727 (1.00) |
0.00621 (1.00) |
1 (1.00) |
1 (1.00) |
0.137 (1.00) |
0.534 (1.00) |
3.74e-25 (3.02e-22) |
1 (1.00) |
0.713 (1.00) |
2Q LOSS MUTATION ANALYSIS | 9 (2%) | 466 |
0.714 (1.00) |
0.134 (1.00) |
0.00103 (0.769) |
0.677 (1.00) |
0.0149 (1.00) |
0.0226 (1.00) |
0.704 (1.00) |
0.00224 (1.00) |
1 (1.00) |
1 (1.00) |
0.15 (1.00) |
0.49 (1.00) |
3.83e-25 (3.09e-22) |
0.738 (1.00) |
0.823 (1.00) |
3Q LOSS MUTATION ANALYSIS | 3 (1%) | 472 |
0.755 (1.00) |
0.229 (1.00) |
0.0435 (1.00) |
0.804 (1.00) |
0.248 (1.00) |
0.134 (1.00) |
1 (1.00) |
0.24 (1.00) |
1 (1.00) |
1 (1.00) |
0.607 (1.00) |
1 (1.00) |
4.28e-25 (3.38e-22) |
0.597 (1.00) |
0.237 (1.00) |
6Q LOSS MUTATION ANALYSIS | 6 (1%) | 469 |
9.71e-05 (0.0743) |
0.0478 (1.00) |
0.185 (1.00) |
0.904 (1.00) |
0.372 (1.00) |
0.0169 (1.00) |
0.19 (1.00) |
0.789 (1.00) |
0.165 (1.00) |
0.188 (1.00) |
0.348 (1.00) |
0.682 (1.00) |
0.002 (1.00) |
0.691 (1.00) |
0.0497 (1.00) |
8P LOSS MUTATION ANALYSIS | 4 (1%) | 471 |
0.867 (1.00) |
0.998 (1.00) |
0.188 (1.00) |
1 (1.00) |
0.248 (1.00) |
0.373 (1.00) |
0.0577 (1.00) |
0.472 (1.00) |
1 (1.00) |
1 (1.00) |
0.636 (1.00) |
1 (1.00) |
4.19e-25 (3.34e-22) |
1 (1.00) |
0.879 (1.00) |
8Q LOSS MUTATION ANALYSIS | 4 (1%) | 471 |
0.867 (1.00) |
0.998 (1.00) |
0.188 (1.00) |
1 (1.00) |
0.248 (1.00) |
0.373 (1.00) |
0.0577 (1.00) |
0.472 (1.00) |
1 (1.00) |
1 (1.00) |
0.636 (1.00) |
1 (1.00) |
4.19e-25 (3.34e-22) |
1 (1.00) |
0.879 (1.00) |
9Q LOSS MUTATION ANALYSIS | 19 (4%) | 456 |
0.0702 (1.00) |
0.0091 (1.00) |
5.93e-11 (4.65e-08) |
0.314 (1.00) |
0.8 (1.00) |
0.0319 (1.00) |
0.117 (1.00) |
0.673 (1.00) |
0.44 (1.00) |
0.534 (1.00) |
0.0686 (1.00) |
0.741 (1.00) |
0.418 (1.00) |
0.817 (1.00) |
0.168 (1.00) |
10P LOSS MUTATION ANALYSIS | 6 (1%) | 469 |
0.741 (1.00) |
0.11 (1.00) |
0.0362 (1.00) |
0.445 (1.00) |
0.0302 (1.00) |
0.182 (1.00) |
0.19 (1.00) |
0.263 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
4.1e-25 (3.28e-22) |
0.421 (1.00) |
0.111 (1.00) |
10Q LOSS MUTATION ANALYSIS | 5 (1%) | 470 |
0.881 (1.00) |
0.108 (1.00) |
0.243 (1.00) |
0.456 (1.00) |
0.061 (1.00) |
0.245 (1.00) |
0.117 (1.00) |
0.579 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
4.19e-25 (3.34e-22) |
0.185 (1.00) |
0.111 (1.00) |
11P LOSS MUTATION ANALYSIS | 7 (1%) | 468 |
0.00188 (1.00) |
0.000502 (0.379) |
2.17e-07 (0.00017) |
0.189 (1.00) |
0.449 (1.00) |
0.0928 (1.00) |
0.0155 (1.00) |
0.827 (1.00) |
0.19 (1.00) |
1 (1.00) |
0.536 (1.00) |
0.504 (1.00) |
0.0804 (1.00) |
0.708 (1.00) |
0.0349 (1.00) |
13Q LOSS MUTATION ANALYSIS | 12 (3%) | 463 |
0.118 (1.00) |
0.0411 (1.00) |
0.42 (1.00) |
0.721 (1.00) |
0.0201 (1.00) |
0.306 (1.00) |
0.315 (1.00) |
0.371 (1.00) |
0.305 (1.00) |
0.000342 (0.259) |
0.69 (1.00) |
0.415 (1.00) |
1.18e-14 (9.23e-12) |
0.399 (1.00) |
0.266 (1.00) |
17Q LOSS MUTATION ANALYSIS | 4 (1%) | 471 |
0.81 (1.00) |
0.377 (1.00) |
0.795 (1.00) |
0.623 (1.00) |
0.123 (1.00) |
0.373 (1.00) |
1 (1.00) |
0.472 (1.00) |
0.113 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
4.28e-25 (3.38e-22) |
1 (1.00) |
0.479 (1.00) |
1P GAIN MUTATION ANALYSIS | 3 (1%) | 472 |
0.916 (1.00) |
0.297 (1.00) |
0.0159 (1.00) |
1 (1.00) |
1 (1.00) |
0.134 (1.00) |
1 (1.00) |
0.349 (1.00) |
1 (1.00) |
0.0798 (1.00) |
1 (1.00) |
0.222 (1.00) |
0.15 (1.00) |
1 (1.00) |
|
8P GAIN MUTATION ANALYSIS | 6 (1%) | 469 |
0.636 (1.00) |
0.624 (1.00) |
0.942 (1.00) |
0.904 (1.00) |
0.623 (1.00) |
0.182 (1.00) |
1 (1.00) |
0.789 (1.00) |
1 (1.00) |
1 (1.00) |
0.348 (1.00) |
0.44 (1.00) |
0.002 (1.00) |
0.225 (1.00) |
0.416 (1.00) |
9P GAIN MUTATION ANALYSIS | 3 (1%) | 472 |
0.698 (1.00) |
0.0778 (1.00) |
0.0435 (1.00) |
0.804 (1.00) |
0.248 (1.00) |
0.609 (1.00) |
1 (1.00) |
0.24 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.597 (1.00) |
0.0605 (1.00) |
|
14Q GAIN MUTATION ANALYSIS | 11 (2%) | 464 |
0.539 (1.00) |
0.0276 (1.00) |
0.00238 (1.00) |
0.369 (1.00) |
0.0678 (1.00) |
0.0323 (1.00) |
0.302 (1.00) |
0.067 (1.00) |
1 (1.00) |
1 (1.00) |
0.821 (1.00) |
0.469 (1.00) |
0.0173 (1.00) |
0.122 (1.00) |
0.305 (1.00) |
22Q GAIN MUTATION ANALYSIS | 3 (1%) | 472 |
0.677 (1.00) |
0.809 (1.00) |
0.811 (1.00) |
0.298 (1.00) |
0.499 (1.00) |
0.609 (1.00) |
0.57 (1.00) |
0.653 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.768 (1.00) |
|||
1P LOSS MUTATION ANALYSIS | 3 (1%) | 472 |
0.769 (1.00) |
0.206 (1.00) |
0.0435 (1.00) |
0.804 (1.00) |
0.248 (1.00) |
0.609 (1.00) |
0.57 (1.00) |
0.24 (1.00) |
1 (1.00) |
1 (1.00) |
0.607 (1.00) |
1 (1.00) |
1 (1.00) |
||
6P LOSS MUTATION ANALYSIS | 3 (1%) | 472 |
0.208 (1.00) |
0.615 (1.00) |
1 (1.00) |
1 (1.00) |
0.134 (1.00) |
1 (1.00) |
0.653 (1.00) |
1 (1.00) |
1 (1.00) |
0.607 (1.00) |
0.434 (1.00) |
0.597 (1.00) |
|||
9P LOSS MUTATION ANALYSIS | 15 (3%) | 460 |
0.684 (1.00) |
0.12 (1.00) |
0.00167 (1.00) |
0.416 (1.00) |
1 (1.00) |
0.0694 (1.00) |
0.0787 (1.00) |
0.75 (1.00) |
1 (1.00) |
1 (1.00) |
0.752 (1.00) |
1 (1.00) |
0.0298 (1.00) |
0.794 (1.00) |
0.282 (1.00) |
15Q LOSS MUTATION ANALYSIS | 6 (1%) | 469 |
0.692 (1.00) |
0.548 (1.00) |
0.0617 (1.00) |
0.445 (1.00) |
0.215 (1.00) |
0.0271 (1.00) |
1 (1.00) |
0.0101 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.386 (1.00) |
1 (1.00) |
0.191 (1.00) |
17P LOSS MUTATION ANALYSIS | 7 (1%) | 468 |
0.597 (1.00) |
0.701 (1.00) |
0.517 (1.00) |
0.132 (1.00) |
0.449 (1.00) |
0.335 (1.00) |
0.682 (1.00) |
0.16 (1.00) |
0.0156 (1.00) |
0.254 (1.00) |
0.176 (1.00) |
0.737 (1.00) |
0.929 (1.00) |
1 (1.00) |
0.0909 (1.00) |
18P LOSS MUTATION ANALYSIS | 4 (1%) | 471 |
0.754 (1.00) |
0.555 (1.00) |
0.188 (1.00) |
0.334 (1.00) |
1 (1.00) |
0.373 (1.00) |
1 (1.00) |
0.472 (1.00) |
1 (1.00) |
1 (1.00) |
0.636 (1.00) |
1 (1.00) |
0.002 (1.00) |
0.628 (1.00) |
0.24 (1.00) |
18Q LOSS MUTATION ANALYSIS | 4 (1%) | 471 |
0.754 (1.00) |
0.555 (1.00) |
0.188 (1.00) |
0.334 (1.00) |
1 (1.00) |
0.373 (1.00) |
1 (1.00) |
0.472 (1.00) |
1 (1.00) |
1 (1.00) |
0.636 (1.00) |
1 (1.00) |
0.002 (1.00) |
0.628 (1.00) |
0.24 (1.00) |
19P LOSS MUTATION ANALYSIS | 4 (1%) | 471 |
0.00071 (0.533) |
0.178 (1.00) |
0.188 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.284 (1.00) |
1 (1.00) |
1 (1.00) |
0.00892 (1.00) |
1 (1.00) |
0.533 (1.00) |
0.628 (1.00) |
||
21Q LOSS MUTATION ANALYSIS | 8 (2%) | 467 |
0.855 (1.00) |
0.0931 (1.00) |
0.00857 (1.00) |
0.168 (1.00) |
0.724 (1.00) |
1 (1.00) |
0.439 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
0.21 (1.00) |
1 (1.00) |
0.98 (1.00) |
0.151 (1.00) |
0.659 (1.00) |
22Q LOSS MUTATION ANALYSIS | 82 (17%) | 393 |
0.607 (1.00) |
0.847 (1.00) |
0.675 (1.00) |
0.378 (1.00) |
0.255 (1.00) |
0.503 (1.00) |
0.494 (1.00) |
0.262 (1.00) |
0.481 (1.00) |
0.331 (1.00) |
0.113 (1.00) |
0.536 (1.00) |
0.244 (1.00) |
0.14 (1.00) |
0.899 (1.00) |
P value = 6.31e-06 (Chi-square test), Q value = 0.0049
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
1Q GAIN MUTATED | 6 | 0 | 9 | 1 | 7 | 0 |
1Q GAIN WILD-TYPE | 264 | 49 | 97 | 1 | 34 | 5 |
P value = 0.000144 (Fisher's exact test), Q value = 0.11
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 137 | 159 | 158 | 19 |
1Q GAIN MUTATED | 2 | 3 | 14 | 4 |
1Q GAIN WILD-TYPE | 135 | 156 | 144 | 15 |
P value = 0.000255 (Fisher's exact test), Q value = 0.19
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 124 | 15 | 320 | 1 |
1Q GAIN MUTATED | 10 | 3 | 9 | 1 |
1Q GAIN WILD-TYPE | 114 | 12 | 311 | 0 |
P value = 4.1e-25 (t-test), Q value = 3.3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
4P GAIN MUTATED | 5 | 0.0 (0.0) |
4P GAIN WILD-TYPE | 374 | 3.6 (6.3) |
P value = 4.1e-25 (t-test), Q value = 3.3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
4Q GAIN MUTATED | 5 | 0.0 (0.0) |
4Q GAIN WILD-TYPE | 374 | 3.6 (6.3) |
P value = 0.000238 (Chi-square test), Q value = 0.18
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
5P GAIN MUTATED | 4 | 5 | 7 | 1 | 1 | 0 |
5P GAIN WILD-TYPE | 266 | 44 | 99 | 1 | 40 | 5 |
P value = 5.66e-05 (Chi-square test), Q value = 0.044
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
5Q GAIN MUTATED | 4 | 5 | 5 | 1 | 0 | 0 |
5Q GAIN WILD-TYPE | 266 | 44 | 101 | 1 | 41 | 5 |
P value = 1.37e-05 (Fisher's exact test), Q value = 0.011
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 258 | 8 | 208 |
5Q GAIN MUTATED | 0 | 0 | 15 |
5Q GAIN WILD-TYPE | 258 | 8 | 193 |
P value = 3.57e-25 (t-test), Q value = 2.9e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
5Q GAIN MUTATED | 11 | 0.0 (0.0) |
5Q GAIN WILD-TYPE | 368 | 3.7 (6.3) |
P value = 3.81e-05 (Chi-square test), Q value = 0.03
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
7P GAIN MUTATED | 6 | 6 | 3 | 1 | 0 | 0 |
7P GAIN WILD-TYPE | 264 | 43 | 103 | 1 | 41 | 5 |
P value = 3.49e-25 (t-test), Q value = 2.8e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
7P GAIN MUTATED | 12 | 0.0 (0.0) |
7P GAIN WILD-TYPE | 367 | 3.7 (6.3) |
P value = 0.000208 (Chi-square test), Q value = 0.16
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
7Q GAIN MUTATED | 7 | 6 | 4 | 1 | 0 | 0 |
7Q GAIN WILD-TYPE | 263 | 43 | 102 | 1 | 41 | 5 |
P value = 3.49e-25 (t-test), Q value = 2.8e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
7Q GAIN MUTATED | 12 | 0.0 (0.0) |
7Q GAIN WILD-TYPE | 367 | 3.7 (6.3) |
P value = 3.05e-06 (Chi-square test), Q value = 0.0024
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
8Q GAIN MUTATED | 3 | 1 | 2 | 1 | 0 | 0 |
8Q GAIN WILD-TYPE | 267 | 48 | 104 | 1 | 41 | 5 |
P value = 0.000155 (t-test), Q value = 0.12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
9Q GAIN MUTATED | 3 | 0.3 (0.6) |
9Q GAIN WILD-TYPE | 376 | 3.6 (6.3) |
P value = 4.19e-25 (t-test), Q value = 3.3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
11P GAIN MUTATED | 4 | 0.0 (0.0) |
11P GAIN WILD-TYPE | 375 | 3.6 (6.3) |
P value = 4.28e-25 (t-test), Q value = 3.4e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
11Q GAIN MUTATED | 3 | 0.0 (0.0) |
11Q GAIN WILD-TYPE | 376 | 3.6 (6.2) |
P value = 9.15e-05 (Fisher's exact test), Q value = 0.07
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 258 | 8 | 208 |
12P GAIN MUTATED | 0 | 0 | 13 |
12P GAIN WILD-TYPE | 258 | 8 | 195 |
P value = 3.66e-25 (t-test), Q value = 3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
12P GAIN MUTATED | 10 | 0.0 (0.0) |
12P GAIN WILD-TYPE | 369 | 3.7 (6.3) |
P value = 4.78e-05 (Fisher's exact test), Q value = 0.037
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 258 | 8 | 208 |
12Q GAIN MUTATED | 0 | 0 | 14 |
12Q GAIN WILD-TYPE | 258 | 8 | 194 |
P value = 3.66e-25 (t-test), Q value = 3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
12Q GAIN MUTATED | 10 | 0.0 (0.0) |
12Q GAIN WILD-TYPE | 369 | 3.7 (6.3) |
P value = 4.19e-25 (t-test), Q value = 3.3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
13Q GAIN MUTATED | 4 | 0.0 (0.0) |
13Q GAIN WILD-TYPE | 375 | 3.6 (6.3) |
P value = 3.74e-25 (t-test), Q value = 3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
16P GAIN MUTATED | 9 | 0.0 (0.0) |
16P GAIN WILD-TYPE | 370 | 3.6 (6.3) |
P value = 7.51e-05 (Chi-square test), Q value = 0.058
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
16Q GAIN MUTATED | 5 | 4 | 2 | 1 | 0 | 0 |
16Q GAIN WILD-TYPE | 265 | 45 | 104 | 1 | 41 | 5 |
P value = 3.83e-25 (t-test), Q value = 3.1e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
16Q GAIN MUTATED | 8 | 0.0 (0.0) |
16Q GAIN WILD-TYPE | 371 | 3.6 (6.3) |
P value = 3.81e-05 (Chi-square test), Q value = 0.03
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
17P GAIN MUTATED | 6 | 6 | 3 | 1 | 0 | 0 |
17P GAIN WILD-TYPE | 264 | 43 | 103 | 1 | 41 | 5 |
P value = 1.44e-06 (t-test), Q value = 0.0011
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
17P GAIN MUTATED | 12 | 0.6 (1.4) |
17P GAIN WILD-TYPE | 367 | 3.7 (6.3) |
P value = 0.000103 (Chi-square test), Q value = 0.078
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
17Q GAIN MUTATED | 7 | 6 | 3 | 1 | 0 | 0 |
17Q GAIN WILD-TYPE | 263 | 43 | 103 | 1 | 41 | 5 |
P value = 2.02e-07 (t-test), Q value = 0.00016
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
17Q GAIN MUTATED | 13 | 0.5 (1.3) |
17Q GAIN WILD-TYPE | 366 | 3.7 (6.3) |
P value = 4.19e-25 (t-test), Q value = 3.3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
18P GAIN MUTATED | 4 | 0.0 (0.0) |
18P GAIN WILD-TYPE | 375 | 3.6 (6.3) |
P value = 4.19e-25 (t-test), Q value = 3.3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
18Q GAIN MUTATED | 4 | 0.0 (0.0) |
18Q GAIN WILD-TYPE | 375 | 3.6 (6.3) |
P value = 3.92e-25 (t-test), Q value = 3.1e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
19P GAIN MUTATED | 7 | 0.0 (0.0) |
19P GAIN WILD-TYPE | 372 | 3.6 (6.3) |
P value = 3.83e-25 (t-test), Q value = 3.1e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
19Q GAIN MUTATED | 8 | 0.0 (0.0) |
19Q GAIN WILD-TYPE | 371 | 3.6 (6.3) |
P value = 5.85e-05 (Chi-square test), Q value = 0.045
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
20P GAIN MUTATED | 4 | 4 | 3 | 1 | 0 | 0 |
20P GAIN WILD-TYPE | 266 | 45 | 103 | 1 | 41 | 5 |
P value = 0.000173 (Fisher's exact test), Q value = 0.13
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 258 | 8 | 208 |
20P GAIN MUTATED | 0 | 0 | 12 |
20P GAIN WILD-TYPE | 258 | 8 | 196 |
P value = 3.83e-25 (t-test), Q value = 3.1e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
20P GAIN MUTATED | 8 | 0.0 (0.0) |
20P GAIN WILD-TYPE | 371 | 3.6 (6.3) |
P value = 5.85e-05 (Chi-square test), Q value = 0.045
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
20Q GAIN MUTATED | 4 | 4 | 3 | 1 | 0 | 0 |
20Q GAIN WILD-TYPE | 266 | 45 | 103 | 1 | 41 | 5 |
P value = 0.000173 (Fisher's exact test), Q value = 0.13
nPatients | M0 | M1 | MX |
---|---|---|---|
ALL | 258 | 8 | 208 |
20Q GAIN MUTATED | 0 | 0 | 12 |
20Q GAIN WILD-TYPE | 258 | 8 | 196 |
P value = 3.83e-25 (t-test), Q value = 3.1e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
20Q GAIN MUTATED | 8 | 0.0 (0.0) |
20Q GAIN WILD-TYPE | 371 | 3.6 (6.3) |
P value = 4.28e-25 (t-test), Q value = 3.4e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
21Q GAIN MUTATED | 3 | 0.0 (0.0) |
21Q GAIN WILD-TYPE | 376 | 3.6 (6.2) |
P value = 8.88e-06 (Chi-square test), Q value = 0.0069
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
XQ GAIN MUTATED | 3 | 2 | 2 | 1 | 0 | 0 |
XQ GAIN WILD-TYPE | 267 | 47 | 104 | 1 | 41 | 5 |
P value = 3.74e-25 (t-test), Q value = 3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
2P LOSS MUTATED | 9 | 0.0 (0.0) |
2P LOSS WILD-TYPE | 370 | 3.6 (6.3) |
P value = 3.83e-25 (t-test), Q value = 3.1e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
2Q LOSS MUTATED | 8 | 0.0 (0.0) |
2Q LOSS WILD-TYPE | 371 | 3.6 (6.3) |
P value = 4.28e-25 (t-test), Q value = 3.4e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
3Q LOSS MUTATED | 3 | 0.0 (0.0) |
3Q LOSS WILD-TYPE | 376 | 3.6 (6.2) |
P value = 9.71e-05 (logrank test), Q value = 0.074
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 470 | 13 | 0.0 - 158.8 (14.2) |
6Q LOSS MUTATED | 5 | 2 | 1.6 - 54.1 (33.6) |
6Q LOSS WILD-TYPE | 465 | 11 | 0.0 - 158.8 (14.0) |
P value = 4.19e-25 (t-test), Q value = 3.3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
8P LOSS MUTATED | 4 | 0.0 (0.0) |
8P LOSS WILD-TYPE | 375 | 3.6 (6.3) |
P value = 4.19e-25 (t-test), Q value = 3.3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
8Q LOSS MUTATED | 4 | 0.0 (0.0) |
8Q LOSS WILD-TYPE | 375 | 3.6 (6.3) |
P value = 5.93e-11 (Chi-square test), Q value = 4.6e-08
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
9Q LOSS MUTATED | 6 | 5 | 3 | 2 | 3 | 0 |
9Q LOSS WILD-TYPE | 264 | 44 | 103 | 0 | 38 | 5 |
P value = 4.1e-25 (t-test), Q value = 3.3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
10P LOSS MUTATED | 5 | 0.0 (0.0) |
10P LOSS WILD-TYPE | 374 | 3.6 (6.3) |
P value = 4.19e-25 (t-test), Q value = 3.3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
10Q LOSS MUTATED | 4 | 0.0 (0.0) |
10Q LOSS WILD-TYPE | 375 | 3.6 (6.3) |
P value = 2.17e-07 (Chi-square test), Q value = 0.00017
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
11P LOSS MUTATED | 1 | 1 | 4 | 1 | 0 | 0 |
11P LOSS WILD-TYPE | 269 | 48 | 102 | 1 | 41 | 5 |
P value = 8.99e-05 (t-test), Q value = 0.069
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 475 | 47.0 (15.5) |
11Q LOSS MUTATED | 9 | 67.0 (8.9) |
11Q LOSS WILD-TYPE | 466 | 46.6 (15.4) |
P value = 7.2e-06 (Chi-square test), Q value = 0.0056
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
11Q LOSS MUTATED | 1 | 2 | 4 | 1 | 1 | 0 |
11Q LOSS WILD-TYPE | 269 | 47 | 102 | 1 | 40 | 5 |
P value = 1.18e-14 (t-test), Q value = 9.2e-12
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
13Q LOSS MUTATED | 10 | 0.2 (0.6) |
13Q LOSS WILD-TYPE | 369 | 3.7 (6.3) |
P value = 4.28e-25 (t-test), Q value = 3.4e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
17Q LOSS MUTATED | 3 | 0.0 (0.0) |
17Q LOSS WILD-TYPE | 376 | 3.6 (6.2) |
P value = 1.57e-06 (Chi-square test), Q value = 0.0012
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 270 | 49 | 106 | 2 | 41 | 5 |
XQ LOSS MUTATED | 0 | 4 | 0 | 0 | 0 | 0 |
XQ LOSS WILD-TYPE | 270 | 45 | 106 | 2 | 41 | 5 |
P value = 4.19e-25 (t-test), Q value = 3.3e-22
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 379 | 3.6 (6.2) |
XQ LOSS MUTATED | 4 | 0.0 (0.0) |
XQ LOSS WILD-TYPE | 375 | 3.6 (6.3) |
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Copy number data file = transformed.cor.cli.txt
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Clinical data file = THCA-TP.clin.merged.picked.txt
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Number of patients = 475
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Number of significantly arm-level cnvs = 55
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Number of selected clinical features = 15
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Exclude regions that fewer than K tumors have mutations, K = 3
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.