Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.112 0.26 -9999.0 0.0 -0.687 35.0 35.0 IHH -0.207 0.371 -9999.0 0.0 -0.839 122.0 122.0 SHH Np/Cholesterol/GAS1 -0.108 0.208 -9999.0 0.0 -0.518 97.0 97.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.107 0.206 0.514 97.0 -9999.0 0.0 97.0 SMO/beta Arrestin2 -0.098 0.243 -9999.0 0.0 -0.484 124.0 124.0 SMO -0.11 0.256 -9999.0 0.0 -0.515 125.0 125.0 AKT1 -0.028 0.125 -9999.0 0.0 -0.665 2.0 2.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.001 0.107 -9999.0 0.0 -0.824 8.0 8.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.108 0.252 -9999.0 0.0 -0.507 125.0 125.0 STIL -0.08 0.2 -9999.0 0.0 -0.599 18.0 18.0 DHH N/PTCH2 -0.107 0.242 -9999.0 0.0 -0.645 80.0 80.0 DHH N/PTCH1 -0.102 0.228 -9999.0 0.0 -0.455 128.0 128.0 PIK3CA 0.008 0.066 -9999.0 0.0 -0.824 3.0 3.0 DHH 0.006 0.076 -9999.0 0.0 -0.824 4.0 4.0 PTHLH -0.16 0.37 -9999.0 0.0 -1.167 35.0 35.0 determination of left/right symmetry -0.108 0.252 -9999.0 0.0 -0.507 125.0 125.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.157 0.363 -9999.0 0.0 -1.141 35.0 35.0 IHH N/Hhip -0.385 0.401 -9999.0 0.0 -0.74 255.0 255.0 DHH N/Hhip -0.25 0.312 -9999.0 0.0 -0.638 188.0 188.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.108 0.252 -9999.0 0.0 -0.507 125.0 125.0 pancreas development -0.313 0.404 -9999.0 0.0 -0.817 188.0 188.0 HHAT 0.012 0.038 -9999.0 0.0 -0.824 1.0 1.0 PI3K -0.004 0.05 -9999.0 0.0 -0.632 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.153 0.334 -9999.0 0.0 -0.824 96.0 96.0 somite specification -0.108 0.252 -9999.0 0.0 -0.507 125.0 125.0 SHH Np/Cholesterol/PTCH1 -0.09 0.205 -9999.0 0.0 -0.426 85.0 85.0 SHH Np/Cholesterol/PTCH2 -0.089 0.19 -9999.0 0.0 -0.515 79.0 79.0 SHH Np/Cholesterol/Megalin -0.14 0.228 -9999.0 0.0 -0.519 127.0 127.0 SHH 0.007 0.05 -9999.0 0.0 -0.632 1.0 1.0 catabolic process -0.117 0.251 -9999.0 0.0 -0.511 125.0 125.0 SMO/Vitamin D3 -0.094 0.224 -9999.0 0.0 -0.445 125.0 125.0 SHH Np/Cholesterol/Hhip -0.204 0.247 -9999.0 0.0 -0.511 187.0 187.0 LRP2 -0.205 0.368 -9999.0 0.0 -0.824 126.0 126.0 receptor-mediated endocytosis -0.2 0.236 -9999.0 0.0 -0.721 47.0 47.0 SHH Np/Cholesterol/BOC -0.014 0.075 -9999.0 0.0 -0.526 9.0 9.0 SHH Np/Cholesterol/CDO -0.153 0.233 -9999.0 0.0 -0.516 140.0 140.0 mesenchymal cell differentiation 0.202 0.245 0.508 187.0 -9999.0 0.0 187.0 mol:Vitamin D3 -0.089 0.209 -9999.0 0.0 -0.414 125.0 125.0 IHH N/PTCH2 -0.234 0.347 -9999.0 0.0 -0.665 178.0 178.0 CDON -0.228 0.379 -9999.0 0.0 -0.824 139.0 139.0 IHH N/PTCH1 -0.119 0.254 -9999.0 0.0 -0.518 125.0 125.0 Megalin/LRPAP1 -0.165 0.278 -9999.0 0.0 -0.632 126.0 126.0 PTCH2 -0.122 0.308 -9999.0 0.0 -0.824 78.0 78.0 SHH Np/Cholesterol -0.006 0.036 -9999.0 0.0 -0.513 1.0 1.0 PTCH1 -0.117 0.252 -9999.0 0.0 -0.513 125.0 125.0 HHIP -0.314 0.405 -9999.0 0.0 -0.818 188.0 188.0