Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.09 0.21 -9999.0 0.0 -0.618 30.0 30.0 IHH -0.157 0.316 -9999.0 0.0 -0.702 119.0 119.0 SHH Np/Cholesterol/GAS1 -0.055 0.159 -9999.0 0.0 -0.395 82.0 82.0 LRPAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.054 0.158 0.392 82.0 -9999.0 0.0 82.0 SMO/beta Arrestin2 -0.077 0.207 -9999.0 0.0 -0.417 110.0 110.0 SMO -0.098 0.209 -9999.0 0.0 -0.433 122.0 122.0 AKT1 -0.017 0.106 -9999.0 0.0 -0.609 2.0 2.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.015 0.09 -9999.0 0.0 -0.675 8.0 8.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.096 0.206 -9999.0 0.0 -0.427 122.0 122.0 STIL -0.067 0.16 0.267 1.0 -0.489 14.0 15.0 DHH N/PTCH2 -0.051 0.205 -9999.0 0.0 -0.511 78.0 78.0 DHH N/PTCH1 -0.079 0.19 -9999.0 0.0 -0.362 142.0 142.0 PIK3CA 0.023 0.055 -9999.0 0.0 -0.675 3.0 3.0 DHH 0.02 0.064 -9999.0 0.0 -0.675 4.0 4.0 PTHLH -0.139 0.311 -9999.0 0.0 -1.032 32.0 32.0 determination of left/right symmetry -0.096 0.206 -9999.0 0.0 -0.427 122.0 122.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.137 0.306 -9999.0 0.0 -1.014 32.0 32.0 IHH N/Hhip -0.294 0.332 -9999.0 0.0 -0.592 251.0 251.0 DHH N/Hhip -0.171 0.266 -9999.0 0.0 -0.506 183.0 183.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.096 0.206 -9999.0 0.0 -0.427 122.0 122.0 pancreas development -0.248 0.331 -9999.0 0.0 -0.67 182.0 182.0 HHAT 0.024 0.033 -9999.0 0.0 -0.675 1.0 1.0 PI3K 0.036 0.044 -9999.0 0.0 -0.509 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.103 0.264 -9999.0 0.0 -0.628 94.0 94.0 somite specification -0.096 0.206 -9999.0 0.0 -0.427 122.0 122.0 SHH Np/Cholesterol/PTCH1 -0.072 0.16 -9999.0 0.0 -0.337 109.0 109.0 SHH Np/Cholesterol/PTCH2 -0.044 0.15 -9999.0 0.0 -0.38 77.0 77.0 SHH Np/Cholesterol/Megalin -0.079 0.178 -9999.0 0.0 -0.383 119.0 119.0 SHH -0.005 0.029 -9999.0 0.0 -0.509 1.0 1.0 catabolic process -0.096 0.204 -9999.0 0.0 -0.405 139.0 139.0 SMO/Vitamin D3 -0.078 0.184 -9999.0 0.0 -0.384 107.0 107.0 SHH Np/Cholesterol/Hhip -0.138 0.201 -9999.0 0.0 -0.408 165.0 165.0 LRP2 -0.151 0.303 -9999.0 0.0 -0.662 124.0 124.0 receptor-mediated endocytosis -0.141 0.211 -9999.0 0.0 -0.563 48.0 48.0 SHH Np/Cholesterol/BOC 0.013 0.057 -9999.0 0.0 -0.373 9.0 9.0 SHH Np/Cholesterol/CDO -0.093 0.185 -9999.0 0.0 -0.382 134.0 134.0 mesenchymal cell differentiation 0.137 0.2 0.406 165.0 -9999.0 0.0 165.0 mol:Vitamin D3 -0.067 0.168 -9999.0 0.0 -0.34 109.0 109.0 IHH N/PTCH2 -0.172 0.288 -9999.0 0.0 -0.531 176.0 176.0 CDON -0.175 0.317 -9999.0 0.0 -0.673 138.0 138.0 IHH N/PTCH1 -0.094 0.209 -9999.0 0.0 -0.41 139.0 139.0 Megalin/LRPAP1 -0.099 0.236 -9999.0 0.0 -0.497 124.0 124.0 PTCH2 -0.086 0.256 -9999.0 0.0 -0.671 77.0 77.0 SHH Np/Cholesterol 0.009 0.023 -9999.0 0.0 -0.404 1.0 1.0 PTCH1 -0.096 0.205 -9999.0 0.0 -0.407 139.0 139.0 HHIP -0.248 0.332 -9999.0 0.0 -0.672 182.0 182.0