Correlation between copy number variations of arm-level result and selected clinical features
Uterine Corpus Endometrioid Carcinoma (Primary solid tumor)
23 September 2013  |  analyses__2013_09_23
Maintainer Information
Citation Information
doi:10.7908/C1NK3CDW
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2013): Correlation between copy number variations of arm-level result and selected clinical features. Broad Institute of MIT and Harvard. doi:10.7908/C1NK3CDW
Overview
Introduction

This pipeline computes the correlation between significant arm-level copy number variations (cnvs) and selected clinical features.

Summary

Testing the association between copy number variation 80 arm-level events and 5 clinical features across 470 patients, 79 significant findings detected with Q value < 0.25.

  • 1P GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 2P GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 2Q GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 3Q GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 5P GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 6P GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 6Q GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 11P GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 12P GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 13Q GAIN MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 14Q GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 17Q GAIN MUTATION ANALYSIS cnv correlated to 'Time to Death'.

  • 18P GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 18Q GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 19P GAIN MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 19Q GAIN MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 20P GAIN MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 20Q GAIN MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 21Q GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 22Q GAIN MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 1P LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 3P LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 3Q LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 4P LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 4Q LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 5P LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 5Q LOSS MUTATION ANALYSIS cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • 6P LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 6Q LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 7P LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 7Q LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 8P LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 8Q LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 9P LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 9Q LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 10P LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 10Q LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 11P LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 11Q LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 12P LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 12Q LOSS MUTATION ANALYSIS cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.

  • 13Q LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 14Q LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 15Q LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 16P LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 16Q LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 17P LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 17Q LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • 18P LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 18Q LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 19P LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 19Q LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 21Q LOSS MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.

  • 22Q LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

  • XQ LOSS MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between significant copy number variation of 80 arm-level events and 5 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 79 significant findings detected.

Clinical
Features 		Time
to
Death 		AGE HISTOLOGICAL
TYPE 		RADIATIONS
RADIATION
REGIMENINDICATION 		COMPLETENESS
OF
RESECTION
nCNV (%) nWild-Type logrank test t-test Fisher's exact test Fisher's exact test Fisher's exact test
13Q GAIN MUTATION ANALYSIS 25 (5%) 445 0.457
(1.00) 		0.00017
(0.056) 		1.67e-06
(0.000593) 		1
(1.00) 		0.0535
(1.00)
19P GAIN MUTATION ANALYSIS 48 (10%) 422 0.0975
(1.00) 		4.78e-08
(1.74e-05) 		1.68e-09
(6.26e-07) 		0.403
(1.00) 		0.655
(1.00)
19Q GAIN MUTATION ANALYSIS 46 (10%) 424 0.0206
(1.00) 		2.47e-08
(9.05e-06) 		1.5e-14
(5.81e-12) 		0.864
(1.00) 		0.583
(1.00)
20P GAIN MUTATION ANALYSIS 88 (19%) 382 0.0276
(1.00) 		1.91e-05
(0.00652) 		5.83e-13
(2.25e-10) 		0.0182
(1.00) 		0.0713
(1.00)
20Q GAIN MUTATION ANALYSIS 105 (22%) 365 0.00104
(0.334) 		8.89e-06
(0.00306) 		1.65e-19
(6.51e-17) 		0.0142
(1.00) 		0.00614
(1.00)
4P LOSS MUTATION ANALYSIS 83 (18%) 387 0.01
(1.00) 		7.38e-05
(0.0249) 		1.06e-20
(4.19e-18) 		0.0443
(1.00) 		0.387
(1.00)
4Q LOSS MUTATION ANALYSIS 81 (17%) 389 0.00815
(1.00) 		0.000112
(0.0373) 		1.08e-18
(4.27e-16) 		0.0146
(1.00) 		0.681
(1.00)
5Q LOSS MUTATION ANALYSIS 61 (13%) 409 0.000597
(0.194) 		0.00991
(1.00) 		1.06e-17
(4.16e-15) 		0.651
(1.00) 		0.284
(1.00)
7P LOSS MUTATION ANALYSIS 36 (8%) 434 0.00758
(1.00) 		0.000102
(0.034) 		1.13e-07
(4.1e-05) 		0.446
(1.00) 		0.221
(1.00)
7Q LOSS MUTATION ANALYSIS 36 (8%) 434 0.302
(1.00) 		2.97e-06
(0.00104) 		5.85e-13
(2.25e-10) 		0.446
(1.00) 		0.205
(1.00)
8P LOSS MUTATION ANALYSIS 66 (14%) 404 0.0631
(1.00) 		8.89e-05
(0.0299) 		5.89e-25
(2.35e-22) 		0.66
(1.00) 		0.324
(1.00)
9P LOSS MUTATION ANALYSIS 82 (17%) 388 0.0382
(1.00) 		2.27e-05
(0.00776) 		4.53e-18
(1.78e-15) 		0.788
(1.00) 		0.119
(1.00)
9Q LOSS MUTATION ANALYSIS 97 (21%) 373 0.0132
(1.00) 		3.62e-09
(1.34e-06) 		9.28e-17
(3.62e-14) 		0.379
(1.00) 		0.32
(1.00)
11P LOSS MUTATION ANALYSIS 65 (14%) 405 0.00698
(1.00) 		0.000243
(0.0797) 		2.22e-12
(8.52e-10) 		0.0548
(1.00) 		0.5
(1.00)
11Q LOSS MUTATION ANALYSIS 60 (13%) 410 0.0384
(1.00) 		0.000554
(0.181) 		3.58e-12
(1.37e-09) 		0.0138
(1.00) 		0.32
(1.00)
12Q LOSS MUTATION ANALYSIS 30 (6%) 440 0.000589
(0.191) 		0.0486
(1.00) 		1.41e-09
(5.27e-07) 		0.404
(1.00) 		0.58
(1.00)
14Q LOSS MUTATION ANALYSIS 51 (11%) 419 0.0355
(1.00) 		0.000705
(0.227) 		2.18e-10
(8.19e-08) 		0.512
(1.00) 		0.441
(1.00)
15Q LOSS MUTATION ANALYSIS 91 (19%) 379 0.0095
(1.00) 		2.57e-06
(0.000904) 		3.93e-21
(1.56e-18) 		0.0714
(1.00) 		0.274
(1.00)
16P LOSS MUTATION ANALYSIS 80 (17%) 390 0.0199
(1.00) 		2.91e-05
(0.00988) 		4.43e-17
(1.73e-14) 		0.222
(1.00) 		0.0203
(1.00)
16Q LOSS MUTATION ANALYSIS 116 (25%) 354 0.0943
(1.00) 		4.96e-07
(0.000176) 		2.84e-21
(1.13e-18) 		0.0978
(1.00) 		0.0185
(1.00)
17P LOSS MUTATION ANALYSIS 107 (23%) 363 0.00263
(0.807) 		1.22e-07
(4.4e-05) 		8.24e-26
(3.3e-23) 		0.397
(1.00) 		0.317
(1.00)
17Q LOSS MUTATION ANALYSIS 74 (16%) 396 0.204
(1.00) 		5.21e-05
(0.0177) 		3.23e-11
(1.23e-08) 		0.265
(1.00) 		0.516
(1.00)
22Q LOSS MUTATION ANALYSIS 92 (20%) 378 0.00762
(1.00) 		8.53e-06
(0.00294) 		3.31e-15
(1.29e-12) 		0.0297
(1.00) 		0.663
(1.00)
XQ LOSS MUTATION ANALYSIS 62 (13%) 408 0.0397
(1.00) 		0.000688
(0.222) 		4.55e-08
(1.66e-05) 		0.0494
(1.00) 		0.187
(1.00)
1P GAIN MUTATION ANALYSIS 29 (6%) 441 0.0203
(1.00) 		0.319
(1.00) 		0.000159
(0.0523) 		0.4
(1.00) 		0.373
(1.00)
2P GAIN MUTATION ANALYSIS 80 (17%) 390 0.0163
(1.00) 		0.00382
(1.00) 		1.74e-08
(6.37e-06) 		0.342
(1.00) 		0.437
(1.00)
2Q GAIN MUTATION ANALYSIS 64 (14%) 406 0.0122
(1.00) 		0.0438
(1.00) 		4.41e-06
(0.00154) 		0.373
(1.00) 		0.207
(1.00)
3Q GAIN MUTATION ANALYSIS 67 (14%) 403 0.00264
(0.808) 		0.00903
(1.00) 		9.81e-09
(3.61e-06) 		0.384
(1.00) 		0.115
(1.00)
5P GAIN MUTATION ANALYSIS 45 (10%) 425 0.00138
(0.435) 		0.0103
(1.00) 		1.62e-10
(6.14e-08) 		0.225
(1.00) 		0.0124
(1.00)
6P GAIN MUTATION ANALYSIS 59 (13%) 411 0.64
(1.00) 		0.129
(1.00) 		5.5e-07
(0.000195) 		0.878
(1.00) 		0.574
(1.00)
6Q GAIN MUTATION ANALYSIS 49 (10%) 421 0.94
(1.00) 		0.201
(1.00) 		6.32e-05
(0.0214) 		0.509
(1.00) 		0.41
(1.00)
11P GAIN MUTATION ANALYSIS 17 (4%) 453 0.0569
(1.00) 		0.0535
(1.00) 		0.000151
(0.0501) 		1
(1.00) 		0.116
(1.00)
12P GAIN MUTATION ANALYSIS 53 (11%) 417 0.26
(1.00) 		0.617
(1.00) 		0.000281
(0.092) 		0.199
(1.00) 		0.673
(1.00)
14Q GAIN MUTATION ANALYSIS 34 (7%) 436 0.352
(1.00) 		0.0865
(1.00) 		7.49e-06
(0.0026) 		0.00564
(1.00) 		0.811
(1.00)
17Q GAIN MUTATION ANALYSIS 26 (6%) 444 0.000101
(0.0339) 		0.0963
(1.00) 		0.00122
(0.387) 		0.825
(1.00) 		0.015
(1.00)
18P GAIN MUTATION ANALYSIS 56 (12%) 414 0.0581
(1.00) 		0.00192
(0.599) 		1.97e-15
(7.68e-13) 		0.637
(1.00) 		0.0119
(1.00)
18Q GAIN MUTATION ANALYSIS 35 (7%) 435 0.0108
(1.00) 		0.0958
(1.00) 		3.88e-07
(0.000138) 		0.846
(1.00) 		0.0287
(1.00)
21Q GAIN MUTATION ANALYSIS 29 (6%) 441 0.0919
(1.00) 		0.00251
(0.775) 		1.37e-07
(4.93e-05) 		0.4
(1.00) 		0.232
(1.00)
22Q GAIN MUTATION ANALYSIS 28 (6%) 442 0.134
(1.00) 		0.00104
(0.334) 		2.02e-09
(7.5e-07) 		0.519
(1.00) 		0.0181
(1.00)
1P LOSS MUTATION ANALYSIS 19 (4%) 451 0.427
(1.00) 		0.0244
(1.00) 		6.12e-06
(0.00214) 		0.798
(1.00) 		0.026
(1.00)
3P LOSS MUTATION ANALYSIS 45 (10%) 425 0.304
(1.00) 		0.00331
(1.00) 		2.04e-10
(7.71e-08) 		0.604
(1.00) 		0.95
(1.00)
3Q LOSS MUTATION ANALYSIS 27 (6%) 443 0.927
(1.00) 		0.0447
(1.00) 		2.05e-06
(0.000723) 		0.278
(1.00) 		0.373
(1.00)
5P LOSS MUTATION ANALYSIS 44 (9%) 426 0.00685
(1.00) 		0.475
(1.00) 		7.17e-11
(2.72e-08) 		0.605
(1.00) 		0.029
(1.00)
6P LOSS MUTATION ANALYSIS 14 (3%) 456 0.753
(1.00) 		0.0518
(1.00) 		1.58e-05
(0.00542) 		1
(1.00) 		0.649
(1.00)
6Q LOSS MUTATION ANALYSIS 20 (4%) 450 0.447
(1.00) 		0.074
(1.00) 		8.72e-08
(3.17e-05) 		0.614
(1.00) 		0.516
(1.00)
8Q LOSS MUTATION ANALYSIS 18 (4%) 452 0.394
(1.00) 		0.458
(1.00) 		2.9e-09
(1.07e-06) 		0.3
(1.00) 		0.271
(1.00)
10P LOSS MUTATION ANALYSIS 29 (6%) 441 0.173
(1.00) 		0.0107
(1.00) 		1.56e-07
(5.6e-05) 		0.4
(1.00) 		0.0482
(1.00)
10Q LOSS MUTATION ANALYSIS 27 (6%) 443 0.301
(1.00) 		0.024
(1.00) 		0.000103
(0.0341) 		0.278
(1.00) 		0.858
(1.00)
12P LOSS MUTATION ANALYSIS 38 (8%) 432 0.000888
(0.285) 		0.033
(1.00) 		3.8e-10
(1.42e-07) 		0.19
(1.00) 		0.0619
(1.00)
13Q LOSS MUTATION ANALYSIS 72 (15%) 398 0.00237
(0.732) 		0.00939
(1.00) 		6.79e-06
(0.00236) 		0.121
(1.00) 		0.639
(1.00)
18P LOSS MUTATION ANALYSIS 42 (9%) 428 0.177
(1.00) 		0.0801
(1.00) 		7.81e-06
(0.0027) 		0.158
(1.00) 		0.256
(1.00)
18Q LOSS MUTATION ANALYSIS 54 (11%) 416 0.307
(1.00) 		0.0448
(1.00) 		1.18e-07
(4.26e-05) 		0.2
(1.00) 		0.278
(1.00)
19P LOSS MUTATION ANALYSIS 48 (10%) 422 0.0246
(1.00) 		0.131
(1.00) 		3.06e-11
(1.17e-08) 		0.403
(1.00) 		0.0838
(1.00)
19Q LOSS MUTATION ANALYSIS 46 (10%) 424 0.0326
(1.00) 		0.162
(1.00) 		5.52e-11
(2.1e-08) 		0.0863
(1.00) 		0.362
(1.00)
21Q LOSS MUTATION ANALYSIS 46 (10%) 424 0.0121
(1.00) 		0.00776
(1.00) 		4.85e-10
(1.82e-07) 		0.735
(1.00) 		0.126
(1.00)
1Q GAIN MUTATION ANALYSIS 156 (33%) 314 0.365
(1.00) 		0.061
(1.00) 		0.634
(1.00) 		0.829
(1.00) 		0.73
(1.00)
3P GAIN MUTATION ANALYSIS 35 (7%) 435 0.0563
(1.00) 		0.347
(1.00) 		0.0258
(1.00) 		0.053
(1.00) 		0.189
(1.00)
4P GAIN MUTATION ANALYSIS 12 (3%) 458 0.415
(1.00) 		0.111
(1.00) 		0.00128
(0.403) 		0.75
(1.00) 		0.105
(1.00)
4Q GAIN MUTATION ANALYSIS 10 (2%) 460 0.923
(1.00) 		0.581
(1.00) 		0.0022
(0.684) 		1
(1.00) 		0.275
(1.00)
5Q GAIN MUTATION ANALYSIS 15 (3%) 455 0.291
(1.00) 		0.45
(1.00) 		0.00754
(1.00) 		0.571
(1.00) 		0.164
(1.00)
7P GAIN MUTATION ANALYSIS 59 (13%) 411 0.0587
(1.00) 		0.281
(1.00) 		0.0481
(1.00) 		0.282
(1.00) 		0.73
(1.00)
7Q GAIN MUTATION ANALYSIS 56 (12%) 414 0.00225
(0.698) 		0.556
(1.00) 		0.161
(1.00) 		0.118
(1.00) 		0.538
(1.00)
8P GAIN MUTATION ANALYSIS 102 (22%) 368 0.128
(1.00) 		0.0384
(1.00) 		0.975
(1.00) 		0.0833
(1.00) 		0.104
(1.00)
8Q GAIN MUTATION ANALYSIS 133 (28%) 337 0.0179
(1.00) 		0.458
(1.00) 		0.00809
(1.00) 		0.0704
(1.00) 		0.163
(1.00)
9P GAIN MUTATION ANALYSIS 17 (4%) 453 0.289
(1.00) 		0.855
(1.00) 		0.0495
(1.00) 		0.171
(1.00) 		0.214
(1.00)
9Q GAIN MUTATION ANALYSIS 8 (2%) 462 0.508
(1.00) 		0.349
(1.00) 		0.0221
(1.00) 		0.449
(1.00) 		0.121
(1.00)
10P GAIN MUTATION ANALYSIS 106 (23%) 364 0.783
(1.00) 		0.386
(1.00) 		0.883
(1.00) 		0.465
(1.00) 		0.781
(1.00)
10Q GAIN MUTATION ANALYSIS 100 (21%) 370 0.467
(1.00) 		0.804
(1.00) 		0.95
(1.00) 		0.535
(1.00) 		0.177
(1.00)
11Q GAIN MUTATION ANALYSIS 14 (3%) 456 0.00344
(1.00) 		0.155
(1.00) 		0.106
(1.00) 		1
(1.00) 		0.0972
(1.00)
12Q GAIN MUTATION ANALYSIS 39 (8%) 431 0.304
(1.00) 		0.651
(1.00) 		0.133
(1.00) 		0.272
(1.00) 		0.717
(1.00)
15Q GAIN MUTATION ANALYSIS 8 (2%) 462 0.00491
(1.00) 		0.86
(1.00) 		0.76
(1.00) 		0.449
(1.00) 		0.0748
(1.00)
16P GAIN MUTATION ANALYSIS 18 (4%) 452 0.812
(1.00) 		0.0986
(1.00) 		0.077
(1.00) 		0.3
(1.00) 		0.228
(1.00)
16Q GAIN MUTATION ANALYSIS 7 (1%) 463 0.847
(1.00) 		0.0635
(1.00) 		0.0522
(1.00) 		0.679
(1.00) 		0.00125
(0.394)
17P GAIN MUTATION ANALYSIS 11 (2%) 459 0.0303
(1.00) 		0.754
(1.00) 		0.425
(1.00) 		1
(1.00) 		0.056
(1.00)
XQ GAIN MUTATION ANALYSIS 55 (12%) 415 0.0213
(1.00) 		0.354
(1.00) 		0.478
(1.00) 		0.43
(1.00) 		0.177
(1.00)
1Q LOSS MUTATION ANALYSIS 11 (2%) 459 0.0306
(1.00) 		0.145
(1.00) 		0.00108
(0.345) 		0.737
(1.00) 		0.072
(1.00)
2P LOSS MUTATION ANALYSIS 9 (2%) 461 0.00926
(1.00) 		0.0994
(1.00) 		0.579
(1.00) 		0.0653
(1.00) 		0.198
(1.00)
2Q LOSS MUTATION ANALYSIS 15 (3%) 455 0.00551
(1.00) 		0.0404
(1.00) 		0.737
(1.00) 		0.00786
(1.00) 		0.271
(1.00)
20P LOSS MUTATION ANALYSIS 19 (4%) 451 0.327
(1.00) 		0.0965
(1.00) 		0.00146
(0.457) 		0.2
(1.00) 		0.124
(1.00)
20Q LOSS MUTATION ANALYSIS 9 (2%) 461 0.248
(1.00) 		0.245
(1.00) 		0.0147
(1.00) 		0.128
(1.00) 		1
(1.00)
'1P GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 0.000159 (Fisher's exact test), Q value = 0.052

Table S1.  Gene #1: '1P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
1P GAIN MUTATED 13 1 15
1P GAIN WILD-TYPE 346 17 78

Figure S1.  Get High-res Image Gene #1: '1P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'2P GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.74e-08 (Fisher's exact test), Q value = 6.4e-06

Table S2.  Gene #3: '2P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
2P GAIN MUTATED 40 4 36
2P GAIN WILD-TYPE 319 14 57

Figure S2.  Get High-res Image Gene #3: '2P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'2Q GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 4.41e-06 (Fisher's exact test), Q value = 0.0015

Table S3.  Gene #4: '2Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
2Q GAIN MUTATED 33 3 28
2Q GAIN WILD-TYPE 326 15 65

Figure S3.  Get High-res Image Gene #4: '2Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'3Q GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 9.81e-09 (Fisher's exact test), Q value = 3.6e-06

Table S4.  Gene #6: '3Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
3Q GAIN MUTATED 31 4 32
3Q GAIN WILD-TYPE 328 14 61

Figure S4.  Get High-res Image Gene #6: '3Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'5P GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.62e-10 (Fisher's exact test), Q value = 6.1e-08

Table S5.  Gene #9: '5P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
5P GAIN MUTATED 15 3 27
5P GAIN WILD-TYPE 344 15 66

Figure S5.  Get High-res Image Gene #9: '5P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'6P GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 5.5e-07 (Fisher's exact test), Q value = 2e-04

Table S6.  Gene #11: '6P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
6P GAIN MUTATED 31 0 28
6P GAIN WILD-TYPE 328 18 65

Figure S6.  Get High-res Image Gene #11: '6P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'6Q GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 6.32e-05 (Fisher's exact test), Q value = 0.021

Table S7.  Gene #12: '6Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
6Q GAIN MUTATED 27 0 22
6Q GAIN WILD-TYPE 332 18 71

Figure S7.  Get High-res Image Gene #12: '6Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'11P GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 0.000151 (Fisher's exact test), Q value = 0.05

Table S8.  Gene #21: '11P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
11P GAIN MUTATED 6 0 11
11P GAIN WILD-TYPE 353 18 82

Figure S8.  Get High-res Image Gene #21: '11P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'12P GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 0.000281 (Fisher's exact test), Q value = 0.092

Table S9.  Gene #23: '12P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
12P GAIN MUTATED 29 2 22
12P GAIN WILD-TYPE 330 16 71

Figure S9.  Get High-res Image Gene #23: '12P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'13Q GAIN MUTATION STATUS' versus 'AGE'

P value = 0.00017 (t-test), Q value = 0.056

Table S10.  Gene #25: '13Q GAIN MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
13Q GAIN MUTATED 25 69.3 (6.4)
13Q GAIN WILD-TYPE 444 63.5 (11.4)

Figure S10.  Get High-res Image Gene #25: '13Q GAIN MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'13Q GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.67e-06 (Fisher's exact test), Q value = 0.00059

Table S11.  Gene #25: '13Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
13Q GAIN MUTATED 8 1 16
13Q GAIN WILD-TYPE 351 17 77

Figure S11.  Get High-res Image Gene #25: '13Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'14Q GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 7.49e-06 (Fisher's exact test), Q value = 0.0026

Table S12.  Gene #26: '14Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
14Q GAIN MUTATED 14 2 18
14Q GAIN WILD-TYPE 345 16 75

Figure S12.  Get High-res Image Gene #26: '14Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'17Q GAIN MUTATION STATUS' versus 'Time to Death'

P value = 0.000101 (logrank test), Q value = 0.034

Table S13.  Gene #31: '17Q GAIN MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 467 56 0.0 - 191.8 (20.9)
17Q GAIN MUTATED 26 8 1.8 - 76.8 (13.4)
17Q GAIN WILD-TYPE 441 48 0.0 - 191.8 (22.5)

Figure S13.  Get High-res Image Gene #31: '17Q GAIN MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

'18P GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.97e-15 (Fisher's exact test), Q value = 7.7e-13

Table S14.  Gene #32: '18P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
18P GAIN MUTATED 17 3 36
18P GAIN WILD-TYPE 342 15 57

Figure S14.  Get High-res Image Gene #32: '18P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'18Q GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 3.88e-07 (Fisher's exact test), Q value = 0.00014

Table S15.  Gene #33: '18Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
18Q GAIN MUTATED 13 2 20
18Q GAIN WILD-TYPE 346 16 73

Figure S15.  Get High-res Image Gene #33: '18Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'19P GAIN MUTATION STATUS' versus 'AGE'

P value = 4.78e-08 (t-test), Q value = 1.7e-05

Table S16.  Gene #34: '19P GAIN MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
19P GAIN MUTATED 48 71.1 (8.5)
19P GAIN WILD-TYPE 421 62.9 (11.3)

Figure S16.  Get High-res Image Gene #34: '19P GAIN MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'19P GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.68e-09 (Fisher's exact test), Q value = 6.3e-07

Table S17.  Gene #34: '19P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
19P GAIN MUTATED 18 3 27
19P GAIN WILD-TYPE 341 15 66

Figure S17.  Get High-res Image Gene #34: '19P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'19Q GAIN MUTATION STATUS' versus 'AGE'

P value = 2.47e-08 (t-test), Q value = 9.1e-06

Table S18.  Gene #35: '19Q GAIN MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
19Q GAIN MUTATED 46 71.4 (8.3)
19Q GAIN WILD-TYPE 423 62.9 (11.3)

Figure S18.  Get High-res Image Gene #35: '19Q GAIN MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'19Q GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.5e-14 (Fisher's exact test), Q value = 5.8e-12

Table S19.  Gene #35: '19Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
19Q GAIN MUTATED 12 3 31
19Q GAIN WILD-TYPE 347 15 62

Figure S19.  Get High-res Image Gene #35: '19Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'20P GAIN MUTATION STATUS' versus 'AGE'

P value = 1.91e-05 (t-test), Q value = 0.0065

Table S20.  Gene #36: '20P GAIN MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
20P GAIN MUTATED 88 68.2 (10.3)
20P GAIN WILD-TYPE 381 62.7 (11.3)

Figure S20.  Get High-res Image Gene #36: '20P GAIN MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'20P GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 5.83e-13 (Fisher's exact test), Q value = 2.2e-10

Table S21.  Gene #36: '20P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
20P GAIN MUTATED 40 4 44
20P GAIN WILD-TYPE 319 14 49

Figure S21.  Get High-res Image Gene #36: '20P GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'20Q GAIN MUTATION STATUS' versus 'AGE'

P value = 8.89e-06 (t-test), Q value = 0.0031

Table S22.  Gene #37: '20Q GAIN MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
20Q GAIN MUTATED 105 67.9 (10.1)
20Q GAIN WILD-TYPE 364 62.6 (11.3)

Figure S22.  Get High-res Image Gene #37: '20Q GAIN MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'20Q GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.65e-19 (Fisher's exact test), Q value = 6.5e-17

Table S23.  Gene #37: '20Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
20Q GAIN MUTATED 45 4 56
20Q GAIN WILD-TYPE 314 14 37

Figure S23.  Get High-res Image Gene #37: '20Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'21Q GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.37e-07 (Fisher's exact test), Q value = 4.9e-05

Table S24.  Gene #38: '21Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
21Q GAIN MUTATED 10 0 19
21Q GAIN WILD-TYPE 349 18 74

Figure S24.  Get High-res Image Gene #38: '21Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'22Q GAIN MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 2.02e-09 (Fisher's exact test), Q value = 7.5e-07

Table S25.  Gene #39: '22Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
22Q GAIN MUTATED 7 1 20
22Q GAIN WILD-TYPE 352 17 73

Figure S25.  Get High-res Image Gene #39: '22Q GAIN MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'1P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 6.12e-06 (Fisher's exact test), Q value = 0.0021

Table S26.  Gene #41: '1P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
1P LOSS MUTATED 5 2 12
1P LOSS WILD-TYPE 354 16 81

Figure S26.  Get High-res Image Gene #41: '1P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'3P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 2.04e-10 (Fisher's exact test), Q value = 7.7e-08

Table S27.  Gene #45: '3P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
3P LOSS MUTATED 15 6 24
3P LOSS WILD-TYPE 344 12 69

Figure S27.  Get High-res Image Gene #45: '3P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'3Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 2.05e-06 (Fisher's exact test), Q value = 0.00072

Table S28.  Gene #46: '3Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
3Q LOSS MUTATED 9 2 16
3Q LOSS WILD-TYPE 350 16 77

Figure S28.  Get High-res Image Gene #46: '3Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'4P LOSS MUTATION STATUS' versus 'AGE'

P value = 7.38e-05 (t-test), Q value = 0.025

Table S29.  Gene #47: '4P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
4P LOSS MUTATED 83 67.9 (9.9)
4P LOSS WILD-TYPE 386 62.9 (11.4)

Figure S29.  Get High-res Image Gene #47: '4P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'4P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.06e-20 (Fisher's exact test), Q value = 4.2e-18

Table S30.  Gene #47: '4P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
4P LOSS MUTATED 29 4 50
4P LOSS WILD-TYPE 330 14 43

Figure S30.  Get High-res Image Gene #47: '4P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'4Q LOSS MUTATION STATUS' versus 'AGE'

P value = 0.000112 (t-test), Q value = 0.037

Table S31.  Gene #48: '4Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
4Q LOSS MUTATED 81 67.9 (10.1)
4Q LOSS WILD-TYPE 388 62.9 (11.3)

Figure S31.  Get High-res Image Gene #48: '4Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'4Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.08e-18 (Fisher's exact test), Q value = 4.3e-16

Table S32.  Gene #48: '4Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
4Q LOSS MUTATED 29 5 47
4Q LOSS WILD-TYPE 330 13 46

Figure S32.  Get High-res Image Gene #48: '4Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'5P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 7.17e-11 (Fisher's exact test), Q value = 2.7e-08

Table S33.  Gene #49: '5P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
5P LOSS MUTATED 15 1 28
5P LOSS WILD-TYPE 344 17 65

Figure S33.  Get High-res Image Gene #49: '5P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'5Q LOSS MUTATION STATUS' versus 'Time to Death'

P value = 0.000597 (logrank test), Q value = 0.19

Table S34.  Gene #50: '5Q LOSS MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 467 56 0.0 - 191.8 (20.9)
5Q LOSS MUTATED 60 15 0.1 - 149.5 (16.8)
5Q LOSS WILD-TYPE 407 41 0.0 - 191.8 (22.8)

Figure S34.  Get High-res Image Gene #50: '5Q LOSS MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

'5Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.06e-17 (Fisher's exact test), Q value = 4.2e-15

Table S35.  Gene #50: '5Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
5Q LOSS MUTATED 18 3 40
5Q LOSS WILD-TYPE 341 15 53

Figure S35.  Get High-res Image Gene #50: '5Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'6P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.58e-05 (Fisher's exact test), Q value = 0.0054

Table S36.  Gene #51: '6P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
6P LOSS MUTATED 3 1 10
6P LOSS WILD-TYPE 356 17 83

Figure S36.  Get High-res Image Gene #51: '6P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'6Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 8.72e-08 (Fisher's exact test), Q value = 3.2e-05

Table S37.  Gene #52: '6Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
6Q LOSS MUTATED 4 1 15
6Q LOSS WILD-TYPE 355 17 78

Figure S37.  Get High-res Image Gene #52: '6Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'7P LOSS MUTATION STATUS' versus 'AGE'

P value = 0.000102 (t-test), Q value = 0.034

Table S38.  Gene #53: '7P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
7P LOSS MUTATED 36 70.6 (9.8)
7P LOSS WILD-TYPE 433 63.2 (11.2)

Figure S38.  Get High-res Image Gene #53: '7P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'7P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.13e-07 (Fisher's exact test), Q value = 4.1e-05

Table S39.  Gene #53: '7P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
7P LOSS MUTATED 13 2 21
7P LOSS WILD-TYPE 346 16 72

Figure S39.  Get High-res Image Gene #53: '7P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'7Q LOSS MUTATION STATUS' versus 'AGE'

P value = 2.97e-06 (t-test), Q value = 0.001

Table S40.  Gene #54: '7Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
7Q LOSS MUTATED 36 70.1 (7.1)
7Q LOSS WILD-TYPE 433 63.2 (11.4)

Figure S40.  Get High-res Image Gene #54: '7Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'7Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 5.85e-13 (Fisher's exact test), Q value = 2.3e-10

Table S41.  Gene #54: '7Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
7Q LOSS MUTATED 8 2 26
7Q LOSS WILD-TYPE 351 16 67

Figure S41.  Get High-res Image Gene #54: '7Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'8P LOSS MUTATION STATUS' versus 'AGE'

P value = 8.89e-05 (t-test), Q value = 0.03

Table S42.  Gene #55: '8P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
8P LOSS MUTATED 66 68.1 (8.9)
8P LOSS WILD-TYPE 403 63.1 (11.5)

Figure S42.  Get High-res Image Gene #55: '8P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'8P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 5.89e-25 (Fisher's exact test), Q value = 2.4e-22

Table S43.  Gene #55: '8P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
8P LOSS MUTATED 15 4 47
8P LOSS WILD-TYPE 344 14 46

Figure S43.  Get High-res Image Gene #55: '8P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'8Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 2.9e-09 (Fisher's exact test), Q value = 1.1e-06

Table S44.  Gene #56: '8Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
8Q LOSS MUTATED 2 1 15
8Q LOSS WILD-TYPE 357 17 78

Figure S44.  Get High-res Image Gene #56: '8Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'9P LOSS MUTATION STATUS' versus 'AGE'

P value = 2.27e-05 (t-test), Q value = 0.0078

Table S45.  Gene #57: '9P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
9P LOSS MUTATED 82 67.9 (8.8)
9P LOSS WILD-TYPE 387 62.9 (11.6)

Figure S45.  Get High-res Image Gene #57: '9P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'9P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 4.53e-18 (Fisher's exact test), Q value = 1.8e-15

Table S46.  Gene #57: '9P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
9P LOSS MUTATED 30 6 46
9P LOSS WILD-TYPE 329 12 47

Figure S46.  Get High-res Image Gene #57: '9P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'9Q LOSS MUTATION STATUS' versus 'AGE'

P value = 3.62e-09 (t-test), Q value = 1.3e-06

Table S47.  Gene #58: '9Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
9Q LOSS MUTATED 97 69.2 (9.1)
9Q LOSS WILD-TYPE 372 62.4 (11.4)

Figure S47.  Get High-res Image Gene #58: '9Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'9Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 9.28e-17 (Fisher's exact test), Q value = 3.6e-14

Table S48.  Gene #58: '9Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
9Q LOSS MUTATED 41 7 49
9Q LOSS WILD-TYPE 318 11 44

Figure S48.  Get High-res Image Gene #58: '9Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'10P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.56e-07 (Fisher's exact test), Q value = 5.6e-05

Table S49.  Gene #59: '10P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
10P LOSS MUTATED 9 2 18
10P LOSS WILD-TYPE 350 16 75

Figure S49.  Get High-res Image Gene #59: '10P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'10Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 0.000103 (Fisher's exact test), Q value = 0.034

Table S50.  Gene #60: '10Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
10Q LOSS MUTATED 11 2 14
10Q LOSS WILD-TYPE 348 16 79

Figure S50.  Get High-res Image Gene #60: '10Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'11P LOSS MUTATION STATUS' versus 'AGE'

P value = 0.000243 (t-test), Q value = 0.08

Table S51.  Gene #61: '11P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
11P LOSS MUTATED 65 68.2 (10.0)
11P LOSS WILD-TYPE 404 63.0 (11.3)

Figure S51.  Get High-res Image Gene #61: '11P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'11P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 2.22e-12 (Fisher's exact test), Q value = 8.5e-10

Table S52.  Gene #61: '11P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
11P LOSS MUTATED 25 5 35
11P LOSS WILD-TYPE 334 13 58

Figure S52.  Get High-res Image Gene #61: '11P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'11Q LOSS MUTATION STATUS' versus 'AGE'

P value = 0.000554 (t-test), Q value = 0.18

Table S53.  Gene #62: '11Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
11Q LOSS MUTATED 60 68.3 (10.3)
11Q LOSS WILD-TYPE 409 63.1 (11.3)

Figure S53.  Get High-res Image Gene #62: '11Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'11Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 3.58e-12 (Fisher's exact test), Q value = 1.4e-09

Table S54.  Gene #62: '11Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
11Q LOSS MUTATED 22 6 32
11Q LOSS WILD-TYPE 337 12 61

Figure S54.  Get High-res Image Gene #62: '11Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'12P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 3.8e-10 (Fisher's exact test), Q value = 1.4e-07

Table S55.  Gene #63: '12P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
12P LOSS MUTATED 12 1 25
12P LOSS WILD-TYPE 347 17 68

Figure S55.  Get High-res Image Gene #63: '12P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'12Q LOSS MUTATION STATUS' versus 'Time to Death'

P value = 0.000589 (logrank test), Q value = 0.19

Table S56.  Gene #64: '12Q LOSS MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

nPatients nDeath Duration Range (Median), Month
ALL 467 56 0.0 - 191.8 (20.9)
12Q LOSS MUTATED 30 9 0.8 - 97.7 (19.3)
12Q LOSS WILD-TYPE 437 47 0.0 - 191.8 (20.9)

Figure S56.  Get High-res Image Gene #64: '12Q LOSS MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'

'12Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.41e-09 (Fisher's exact test), Q value = 5.3e-07

Table S57.  Gene #64: '12Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
12Q LOSS MUTATED 8 1 21
12Q LOSS WILD-TYPE 351 17 72

Figure S57.  Get High-res Image Gene #64: '12Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'13Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 6.79e-06 (Fisher's exact test), Q value = 0.0024

Table S58.  Gene #65: '13Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
13Q LOSS MUTATED 39 3 30
13Q LOSS WILD-TYPE 320 15 63

Figure S58.  Get High-res Image Gene #65: '13Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'14Q LOSS MUTATION STATUS' versus 'AGE'

P value = 0.000705 (t-test), Q value = 0.23

Table S59.  Gene #66: '14Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
14Q LOSS MUTATED 51 68.0 (8.7)
14Q LOSS WILD-TYPE 418 63.2 (11.5)

Figure S59.  Get High-res Image Gene #66: '14Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'14Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 2.18e-10 (Fisher's exact test), Q value = 8.2e-08

Table S60.  Gene #66: '14Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
14Q LOSS MUTATED 19 3 29
14Q LOSS WILD-TYPE 340 15 64

Figure S60.  Get High-res Image Gene #66: '14Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'15Q LOSS MUTATION STATUS' versus 'AGE'

P value = 2.57e-06 (t-test), Q value = 9e-04

Table S61.  Gene #67: '15Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
15Q LOSS MUTATED 91 68.7 (10.5)
15Q LOSS WILD-TYPE 378 62.6 (11.2)

Figure S61.  Get High-res Image Gene #67: '15Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'15Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 3.93e-21 (Fisher's exact test), Q value = 1.6e-18

Table S62.  Gene #67: '15Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
15Q LOSS MUTATED 33 6 52
15Q LOSS WILD-TYPE 326 12 41

Figure S62.  Get High-res Image Gene #67: '15Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'16P LOSS MUTATION STATUS' versus 'AGE'

P value = 2.91e-05 (t-test), Q value = 0.0099

Table S63.  Gene #68: '16P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
16P LOSS MUTATED 80 68.3 (9.9)
16P LOSS WILD-TYPE 389 62.8 (11.3)

Figure S63.  Get High-res Image Gene #68: '16P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'16P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 4.43e-17 (Fisher's exact test), Q value = 1.7e-14

Table S64.  Gene #68: '16P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
16P LOSS MUTATED 30 5 45
16P LOSS WILD-TYPE 329 13 48

Figure S64.  Get High-res Image Gene #68: '16P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'16Q LOSS MUTATION STATUS' versus 'AGE'

P value = 4.96e-07 (t-test), Q value = 0.00018

Table S65.  Gene #69: '16Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
16Q LOSS MUTATED 116 68.0 (9.6)
16Q LOSS WILD-TYPE 353 62.4 (11.5)

Figure S65.  Get High-res Image Gene #69: '16Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'16Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 2.84e-21 (Fisher's exact test), Q value = 1.1e-18

Table S66.  Gene #69: '16Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
16Q LOSS MUTATED 50 6 60
16Q LOSS WILD-TYPE 309 12 33

Figure S66.  Get High-res Image Gene #69: '16Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'17P LOSS MUTATION STATUS' versus 'AGE'

P value = 1.22e-07 (t-test), Q value = 4.4e-05

Table S67.  Gene #70: '17P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
17P LOSS MUTATED 107 68.3 (9.3)
17P LOSS WILD-TYPE 362 62.4 (11.5)

Figure S67.  Get High-res Image Gene #70: '17P LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'17P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 8.24e-26 (Fisher's exact test), Q value = 3.3e-23

Table S68.  Gene #70: '17P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
17P LOSS MUTATED 39 8 60
17P LOSS WILD-TYPE 320 10 33

Figure S68.  Get High-res Image Gene #70: '17P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'17Q LOSS MUTATION STATUS' versus 'AGE'

P value = 5.21e-05 (t-test), Q value = 0.018

Table S69.  Gene #71: '17Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
17Q LOSS MUTATED 74 68.4 (10.1)
17Q LOSS WILD-TYPE 395 62.9 (11.3)

Figure S69.  Get High-res Image Gene #71: '17Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'17Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 3.23e-11 (Fisher's exact test), Q value = 1.2e-08

Table S70.  Gene #71: '17Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
17Q LOSS MUTATED 32 6 36
17Q LOSS WILD-TYPE 327 12 57

Figure S70.  Get High-res Image Gene #71: '17Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'18P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 7.81e-06 (Fisher's exact test), Q value = 0.0027

Table S71.  Gene #72: '18P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
18P LOSS MUTATED 19 5 18
18P LOSS WILD-TYPE 340 13 75

Figure S71.  Get High-res Image Gene #72: '18P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'18Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 1.18e-07 (Fisher's exact test), Q value = 4.3e-05

Table S72.  Gene #73: '18Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
18Q LOSS MUTATED 24 6 24
18Q LOSS WILD-TYPE 335 12 69

Figure S72.  Get High-res Image Gene #73: '18Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'19P LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 3.06e-11 (Fisher's exact test), Q value = 1.2e-08

Table S73.  Gene #74: '19P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
19P LOSS MUTATED 16 4 28
19P LOSS WILD-TYPE 343 14 65

Figure S73.  Get High-res Image Gene #74: '19P LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'19Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 5.52e-11 (Fisher's exact test), Q value = 2.1e-08

Table S74.  Gene #75: '19Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
19Q LOSS MUTATED 15 4 27
19Q LOSS WILD-TYPE 344 14 66

Figure S74.  Get High-res Image Gene #75: '19Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'21Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 4.85e-10 (Fisher's exact test), Q value = 1.8e-07

Table S75.  Gene #78: '21Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
21Q LOSS MUTATED 16 4 26
21Q LOSS WILD-TYPE 343 14 67

Figure S75.  Get High-res Image Gene #78: '21Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'22Q LOSS MUTATION STATUS' versus 'AGE'

P value = 8.53e-06 (t-test), Q value = 0.0029

Table S76.  Gene #79: '22Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
22Q LOSS MUTATED 92 67.9 (9.2)
22Q LOSS WILD-TYPE 377 62.8 (11.5)

Figure S76.  Get High-res Image Gene #79: '22Q LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'22Q LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 3.31e-15 (Fisher's exact test), Q value = 1.3e-12

Table S77.  Gene #79: '22Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
22Q LOSS MUTATED 39 8 45
22Q LOSS WILD-TYPE 320 10 48

Figure S77.  Get High-res Image Gene #79: '22Q LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'XQ LOSS MUTATION STATUS' versus 'AGE'

P value = 0.000688 (t-test), Q value = 0.22

Table S78.  Gene #80: 'XQ LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 469 63.8 (11.3)
XQ LOSS MUTATED 62 67.8 (9.5)
XQ LOSS WILD-TYPE 407 63.1 (11.4)

Figure S78.  Get High-res Image Gene #80: 'XQ LOSS MUTATION STATUS' versus Clinical Feature #2: 'AGE'

'XQ LOSS MUTATION STATUS' versus 'HISTOLOGICAL.TYPE'

P value = 4.55e-08 (Fisher's exact test), Q value = 1.7e-05

Table S79.  Gene #80: 'XQ LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA MIXED SEROUS AND ENDOMETRIOID SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL 359 18 93
XQ LOSS MUTATED 29 3 30
XQ LOSS WILD-TYPE 330 15 63

Figure S79.  Get High-res Image Gene #80: 'XQ LOSS MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

Methods & Data
Input

  • Copy number data file = transformed.cor.cli.txt

  • Clinical data file = UCEC-TP.clin.merged.picked.txt

  • Number of patients = 470

  • Number of significantly arm-level cnvs = 80

  • Number of selected clinical features = 5

  • Exclude regions that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)
[3] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[4] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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