rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(4), EIF4A1(5), EIF4A2(9), EIF4B(7), EIF4E(2), EIF4G1(15), EIF4G2(7), EIF4G3(24), FKBP1A(1), MKNK1(3), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), PTEN(228), RPS6(7), RPS6KB1(5), TSC1(13), TSC2(15)	9925342	631	218	417	44	91	141	126	38	191	44	<1.00e-15	<1.00e-15	<3.96e-14
2	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF4E(2), GSK3B(13), IGF1(5), IGF1R(13), INPPL1(19), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), PTEN(228), RPS6(7), RPS6KB1(5)	7138255	604	217	388	46	80	131	117	40	194	42	<1.00e-15	<1.00e-15	<3.96e-14
3	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(4), APC(56), AXIN1(9), CCND1(15), CD14(2), CTNNB1(80), DVL1(3), FZD1(3), GJA1(5), GNAI1(5), GSK3B(13), IRAK1(4), LBP(3), LEF1(9), LY96(4), MYD88(3), NFKB1(10), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), RELA(6), TIRAP(2), TLR4(17), TOLLIP(1), WNT1(1)	10634125	536	210	356	58	77	201	122	6	110	20	2.06e-13	<1.00e-15	<3.96e-14
4	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(21), AKT1(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CREB1(6), GNAS(24), GRB2(3), HRAS(1), MAPK1(2), MAPK14(4), MAPK3(3), PIK3CA(172), PIK3R1(100), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), RAC1(1), RPS6KA1(1), RPS6KA5(11), SOS1(13)	10330216	425	200	300	54	88	113	111	5	92	16	4.56e-08	<1.00e-15	<3.96e-14
5	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(32), EP300(32), FYN(7), IL2RG(13), IL7(1), IL7R(12), JAK1(20), JAK3(10), LCK(5), NMI(3), PIK3CA(172), PIK3R1(100), PTK2B(16), STAT5A(5), STAT5B(7)	10213532	435	200	312	56	77	121	115	6	100	16	3.60e-08	<1.00e-15	<3.96e-14
6	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(9), EGF(20), EGFR(12), ELK1(3), FOS(3), GRB2(3), HRAS(1), JAK1(20), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SRF(3), STAT1(15), STAT3(10), STAT5A(5)	13675029	511	199	380	61	99	144	131	4	116	17	8.39e-11	<1.00e-15	<3.96e-14
7	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(4), CREB1(6), GRB2(3), HRAS(1), MAPK1(2), MAPK3(3), MAPK7(14), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), NTRK1(13), PIK3CA(172), PIK3R1(100), PLCG1(12), RPS6KA1(1), SHC1(7)	7017966	360	199	240	37	64	100	96	6	79	15	1.94e-09	<1.00e-15	<3.96e-14
8	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(21), ARHGEF1(12), F2(8), F2R(6), GNA12(8), GNA13(7), GNAI1(5), GNAQ(3), GNB1(2), GNGT1(1), MAP3K7(9), PIK3CA(172), PIK3R1(100), PLCB1(5), PPP1R12B(20), PRKCA(10), PTK2B(16), ROCK1(22)	9289594	427	199	304	63	96	111	112	7	84	17	2.95e-06	<1.00e-15	<3.96e-14
9	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(7), AKT1(4), ANXA1(5), CALM1(2), CALM2(4), GNAS(24), GNB1(2), GNGT1(1), NFKB1(10), NOS3(11), NPPA(2), NR3C1(18), PIK3CA(172), PIK3R1(100), RELA(6), SYT1(4)	6288912	372	197	249	26	79	99	91	4	84	15	9.69e-14	<1.00e-15	<3.96e-14
10	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(4), BAD(2), BCL2L1(4), CASP9(3), CDC42(4), CHUK(8), ELK1(3), H2AFX(1), HRAS(1), MAP2K1(2), MAPK3(3), NFKB1(10), PIK3CA(172), PIK3R1(100), RAC1(1), RAF1(8), RALA(6), RALBP1(6), RALGDS(9), RELA(6), RHOA(3)	6942603	356	197	235	28	56	106	95	4	78	17	4.18e-12	<1.00e-15	<3.96e-14
11	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(4), DPM2(2), GRB2(3), HRAS(1), KLK2(2), NTRK1(13), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), SHC1(7), SOS1(13)	5625851	339	197	216	32	54	97	95	4	74	15	1.34e-08	<1.00e-15	<3.96e-14
12	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(4), PAK1(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), RAC1(1), WASL(9)	4979142	334	195	214	16	51	90	92	4	81	16	7.55e-15	<1.00e-15	<3.96e-14
13	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(4), CAT(4), GH1(3), GHR(8), HRAS(1), IGF1(5), IGF1R(13), PIK3CA(172), PIK3R1(100), SHC1(7), SOD1(2), SOD2(3)	4715937	322	195	203	28	53	83	91	5	75	15	1.75e-09	<1.00e-15	<3.96e-14
14	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(8), DNAJC3(9), EIF2S1(2), EIF2S2(9), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), TP53(74)	3670290	127	84	100	10	32	39	26	3	27	0	2.41e-06	<1.00e-15	<3.96e-14
15	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(4), CREB1(6), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(10), PIK3CA(172), PIK3R1(100), RB1(26), RELA(6), SP1(7)	7166136	394	200	272	31	63	112	107	4	89	19	2.19e-12	1.11e-15	3.96e-14
16	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(4), AKT2(6), AKT3(11), BPNT1(3), GRB2(3), ILK(5), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(172), PIK3CD(12), PTEN(228), PTK2B(16), RBL2(19), SHC1(7), SOS1(13)	7243620	506	208	307	39	92	126	107	36	117	28	<1.00e-15	1.22e-15	3.96e-14
17	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), JAK1(20), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), PDGFA(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SRF(3), STAT1(15), STAT3(10), STAT5A(5)	12730148	506	201	375	56	94	144	134	4	112	18	5.97e-12	1.22e-15	3.96e-14
18	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(21), AKT1(4), BAD(2), BAX(3), BCL2L1(4), CSF2RB(14), IGF1(5), IGF1R(13), IL3(2), IL3RA(9), KIT(24), KITLG(3), PIK3CA(172), PIK3R1(100), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), YWHAH(3)	7856210	406	200	286	52	74	120	107	6	83	16	3.11e-09	1.22e-15	3.96e-14
19	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(3), CD3D(6), CD3E(2), CD3G(3), CD80(5), CD86(5), CTLA4(2), GRB2(3), HLA-DRA(1), ICOS(3), IL2(2), ITK(7), LCK(5), PIK3CA(172), PIK3R1(100), PTPN11(8)	4602586	327	194	208	19	48	91	88	5	80	15	1.67e-12	1.22e-15	3.96e-14
20	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(4), BAD(2), CHRNB1(2), CHRNG(4), MUSK(15), PIK3CA(172), PIK3R1(100), PTK2(12), PTK2B(16), RAPSN(2), SRC(3), TERT(4), YWHAH(3)	5901003	339	197	220	43	57	93	94	4	76	15	2.46e-06	1.44e-15	4.23e-14
21	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	DUSP1(2), GORASP1(10), IKBKG(4), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5), MAPKAPK5(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), SYT1(4), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(7)	11364262	433	197	313	59	93	116	105	4	99	16	1.57e-08	1.44e-15	4.23e-14
22	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(8), CDKN2A(2), E2F1(9), MDM2(4), MYC(8), PIK3CA(172), PIK3R1(100), POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), RAC1(1), RB1(26), TBX2(2), TP53(74), TWIST1(1)	7080267	444	223	300	50	87	115	119	6	99	18	4.87e-10	1.78e-15	4.56e-14
23	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(4), BCAR1(8), CDKN1B(7), GRB2(3), ILK(5), ITGB1(8), MAPK1(2), MAPK3(3), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PTEN(228), PTK2(12), SHC1(7), SOS1(13)	6867110	580	213	364	30	73	121	124	37	183	42	<1.00e-15	1.78e-15	4.56e-14
24	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), INS(3), INSR(18), IRS1(13), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(10), PIK3CA(172), PIK3R1(100), PTPN11(8), RAF1(8), RASA1(30), SHC1(7), SLC2A4(9), SOS1(13), SRF(3)	9128952	419	202	292	39	82	118	108	5	90	16	3.73e-13	1.78e-15	4.56e-14
25	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(3), AKT1(4), AKT2(6), AKT3(11), BAD(2), BTK(12), CDKN2A(2), DAPP1(9), GRB2(3), GSK3A(10), GSK3B(13), IARS(8), IGFBP1(4), INPP5D(9), PDK1(2), PIK3CA(172), PPP1R13B(9), PTEN(228), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SHC1(7), SOS1(13), SOS2(17), TEC(8), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	13065934	603	211	404	65	113	161	131	37	133	28	1.89e-15	2.00e-15	4.72e-14
26	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(21), DIAPH1(13), FYN(7), GSN(5), HRAS(1), ITGA1(17), ITGB1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(2), MYLK(14), PFN1(1), PIK3CA(172), PIK3R1(100), PTK2(12), PXN(6), RAF1(8), ROCK1(22), SHC1(7), SRC(3), TLN1(23)	13836087	449	199	329	53	93	128	116	4	91	17	7.62e-10	2.11e-15	4.72e-14
27	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(4), BCR(6), CRKL(6), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), MYC(8), PIK3CA(172), PIK3R1(100), RAF1(8), SOS1(13), STAT1(15), STAT5A(5), STAT5B(7)	9960926	423	199	298	39	75	122	113	4	90	19	1.16e-12	2.33e-15	4.72e-14
28	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(4), PIK3CA(172), PIK3R1(100), PLCB1(5), PLCG1(12), PRKCA(10), VAV1(12)	4719996	315	194	195	39	51	75	91	7	76	15	8.56e-05	2.33e-15	4.72e-14
29	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(5), MAX(12), MYC(8), SP1(7), SP3(11), TP53(74), WT1(3)	2507279	120	91	91	10	36	32	28	2	22	0	1.28e-06	2.33e-15	4.72e-14
30	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(3), GHR(8), GRB2(3), HRAS(1), INS(3), INSR(18), IRS1(13), JAK2(17), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), PTPN6(6), RAF1(8), RPS6KA1(1), SHC1(7), SLC2A4(9), SOS1(13), SRF(3), STAT5A(5), STAT5B(7)	11855606	426	197	302	59	93	114	115	5	81	18	2.38e-07	2.44e-15	4.72e-14
31	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(21), AKT1(4), ASAH1(7), GNAI1(5), GNB1(2), GNGT1(1), ITGAV(10), ITGB3(11), MAPK1(2), MAPK3(3), PDGFA(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), PLCB1(5), PRKCA(10), PTK2(12), RAC1(1), SMPD1(11), SMPD2(7), SPHK1(2), SRC(3)	9845923	416	201	295	65	72	117	114	6	90	17	1.52e-05	2.55e-15	4.72e-14
32	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(4), AKT2(6), AKT3(11), BRD4(10), CAP1(7), CBL(12), CDC42(4), CDKN2A(2), F2RL2(2), FLOT1(1), FLOT2(2), GRB2(3), GSK3A(10), GSK3B(13), IGFBP1(4), INPPL1(19), IRS1(13), IRS4(21), LNPEP(10), MAPK1(2), MAPK3(3), PARD3(19), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PPYR1(8), PTEN(228), PTPN1(5), RAF1(8), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SERPINB6(3), SHC1(7), SLC2A4(9), SORBS1(18), SOS1(13), SOS2(17), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	20615343	831	217	606	121	161	197	174	40	215	44	9.38e-12	2.66e-15	4.72e-14
33	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(5), EIF1(1), EIF2B2(5), EIF2B3(7), EIF2B4(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), ELAVL1(8), FLT1(20), FLT4(9), HIF1A(16), HRAS(1), KDR(26), NOS3(11), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), PTK2(12), PXN(6), SHC1(7), VHL(3)	12174092	457	197	334	59	94	128	110	7	103	15	3.73e-09	2.78e-15	4.72e-14
34	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(5), AGT(8), AKT1(4), CALM1(2), CALM2(4), CALR(3), CAMK1(2), CAMK1G(5), CAMK4(5), CREBBP(32), CSNK1A1(4), EDN1(4), ELSPBP1(5), F2(8), FKBP1A(1), GATA4(3), GSK3B(13), HAND1(6), HRAS(1), IGF1(5), LIF(3), MAP2K1(2), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(10), MEF2C(11), MYH2(43), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NKX2-5(2), NPPA(2), PIK3CA(172), PIK3R1(100), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RAF1(8), RPS6KB1(5), SYT1(4)	18041266	575	207	445	97	126	176	137	5	113	18	4.11e-08	2.89e-15	4.72e-14
35	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IGF1(5), IGF1R(13), IRS1(13), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(10), PIK3CA(172), PIK3R1(100), PTPN11(8), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SRF(3)	8874392	407	200	280	36	72	117	108	5	89	16	5.21e-13	2.89e-15	4.72e-14
36	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(9), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAPK3(3), MPL(7), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), RAF1(8), RASA1(30), SHC1(7), SOS1(13), STAT1(15), STAT3(10), STAT5A(5), STAT5B(7), THPO(7)	10932923	442	196	313	50	83	126	118	4	92	19	2.33e-09	2.89e-15	4.72e-14
37	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(5), CRK(2), CRKL(6), DOCK1(24), ELK1(3), FOS(3), GAB1(8), GRB2(3), HGF(14), HRAS(1), ITGA1(17), ITGB1(8), JUN(1), MAP2K1(2), MAP2K2(5), MAP4K1(11), MAPK1(2), MAPK3(3), MAPK8(10), MET(17), PAK1(3), PIK3CA(172), PIK3R1(100), PTEN(228), PTK2(12), PTK2B(16), PTPN11(8), PXN(6), RAF1(8), RAP1A(4), RAP1B(2), RASA1(30), SOS1(13), SRC(3), STAT3(10)	16563754	760	217	538	93	135	188	148	37	208	44	7.33e-15	3.00e-15	4.72e-14
38	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(4), AKT2(6), AKT3(11), BAD(2), GRB2(3), GSK3A(10), GSK3B(13), IL4R(6), IRS1(13), JAK1(20), JAK3(10), MAP4K1(11), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PPP1R13B(9), RAF1(8), SHC1(7), SOS1(13), SOS2(17), STAT6(10)	12574116	464	202	337	55	106	123	119	5	95	16	9.87e-11	3.00e-15	4.72e-14
39	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(2), CDK5R1(3), CFL1(1), CHN1(3), LIMK1(8), MAP3K1(30), MYL2(2), MYLK(14), NCF2(8), PAK1(3), PDGFRA(24), PIK3CA(172), PIK3R1(100), PLD1(14), PPP1R12B(20), RAC1(1), RALBP1(6), RPS6KB1(5), TRIO(34), VAV1(12), WASF1(3)	12890193	466	200	341	66	88	134	115	6	104	19	1.52e-07	3.11e-15	4.72e-14
40	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(3), HLA-A(1), IL18(2), ITGB1(8), KLRC1(7), KLRC2(3), KLRC3(1), KLRC4(5), KLRD1(3), MAP2K1(2), MAPK3(3), PAK1(3), PIK3CA(172), PIK3R1(100), PTK2B(16), PTPN6(6), RAC1(1), SYK(4), VAV1(12)	6852023	352	196	232	34	59	99	93	5	81	15	2.61e-09	3.11e-15	4.72e-14
41	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(4), CCND1(15), CCNE1(6), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN1B(7), E2F1(9), HRAS(1), MAPK1(2), MAPK3(3), NFKB1(10), NFKBIA(3), PAK1(3), PIK3CA(172), PIK3R1(100), RAC1(1), RAF1(8), RB1(26), RELA(6), TFDP1(13)	7293532	398	202	274	38	67	107	108	4	94	18	6.76e-11	3.22e-15	4.72e-14
42	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(4), AKT2(6), AKT3(11), CDKN1A(1), ELK1(3), GRB2(3), HRAS(1), MAP2K1(2), MAP2K2(5), NGFR(3), NTRK1(13), PIK3CA(172), PIK3CD(12), SHC1(7), SOS1(13)	5624797	256	151	155	33	59	99	82	3	13	0	7.82e-08	3.22e-15	4.72e-14
43	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(4), BAD(2), BCL2L1(4), CBL(12), CFLAR(6), CRKL(6), E2F1(9), FOS(3), GRB2(3), HRAS(1), IL2RA(4), IL2RB(3), IL2RG(13), IRS1(13), JAK1(20), JAK3(10), MAPK1(2), MAPK3(3), MYC(8), NMI(3), PIK3CA(172), PIK3R1(100), PPIA(1), PTPN6(6), RAF1(8), RPS6KB1(5), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7), SYK(4)	12777577	457	203	334	55	84	140	122	5	91	15	1.98e-10	3.33e-15	4.77e-14
44	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(4), CABIN1(19), CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), HDAC5(12), IGF1(5), IGF1R(13), INS(3), INSR(18), MAP2K6(10), MAPK14(4), MAPK7(14), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), NFATC1(10), NFATC2(13), PIK3CA(172), PIK3R1(100), PPP3CA(4), PPP3CB(5), PPP3CC(6), SYT1(4), YWHAH(3)	12178275	454	202	331	72	109	116	116	8	90	15	2.18e-07	4.00e-15	5.60e-14
45	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(8), CRK(2), CXCL12(6), CXCR4(1), GNAI1(5), GNAQ(3), GNB1(2), GNGT1(1), HRAS(1), MAP2K1(2), MAPK1(2), MAPK3(3), NFKB1(10), PIK3C2G(16), PIK3CA(172), PIK3R1(100), PLCG1(12), PRKCA(10), PTK2(12), PTK2B(16), PXN(6), RAF1(8), RELA(6)	10130836	404	196	282	58	82	109	108	4	86	15	2.26e-06	4.11e-15	5.62e-14
46	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(4), BAD(2), CASP9(3), CHUK(8), GH1(3), GHR(8), NFKB1(10), NFKBIA(3), PDPK1(3), PIK3CA(172), PIK3R1(100), PPP2CA(6), RELA(6), YWHAH(3)	5135005	331	199	212	19	49	93	92	4	78	15	4.49e-13	4.88e-15	6.54e-14
47	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(4), BAD(2), GRB2(3), HRAS(1), IGF1R(13), IRS1(13), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(172), PIK3R1(100), RAF1(8), SHC1(7), SOS1(13), YWHAH(3)	6731221	346	196	223	34	62	91	97	5	76	15	3.85e-09	5.11e-15	6.69e-14
48	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(4), EIF4A1(5), EIF4A2(9), EIF4E(2), EIF4G1(15), EIF4G2(7), EIF4G3(24), GHR(8), IRS1(13), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(3), PABPC1(11), PDK2(5), PDPK1(3), PIK3CA(172), PIK3R1(100), PRKCA(10), PTEN(228), RPS6KB1(5)	10144798	633	216	418	49	92	134	133	39	191	44	<1.00e-15	5.33e-15	6.70e-14
49	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(9), DPM2(2), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), KLK2(2), MAP2K1(2), MAPK3(3), MAPK8(10), NGFR(3), PIK3CA(172), PIK3R1(100), PLCG1(12), RAF1(8), SHC1(7), SOS1(13)	6810755	354	194	228	24	58	100	101	4	76	15	3.42e-13	5.33e-15	6.70e-14
50	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(3), ARF3(4), CCND1(15), CDK2(2), CDK4(3), CDKN1A(1), CDKN1B(7), CDKN2A(2), CFL1(1), E2F1(9), E2F2(3), MDM2(4), PRB1(2), TP53(74)	2834146	130	99	104	21	35	37	31	1	26	0	0.00250	5.55e-15	6.84e-14
51	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(12), CALM1(2), CALM2(4), ELK1(3), FCER1A(9), FCER1G(2), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP2K4(9), MAP2K7(4), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(10), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), PAK2(3), PIK3CA(172), PIK3R1(100), PLA2G4A(13), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), RAF1(8), SHC1(7), SOS1(13), SYK(4), SYT1(4), VAV1(12)	15285000	514	199	386	78	103	160	124	6	105	16	2.19e-07	5.66e-15	6.84e-14
52	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(2), CALM2(4), CD3D(6), CD3E(2), CD3G(3), ELK1(3), FOS(3), FYN(7), GRB2(3), HRAS(1), JUN(1), LCK(5), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(10), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NFKB1(10), NFKBIA(3), PIK3CA(172), PIK3R1(100), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), PTPN7(6), RAC1(1), RAF1(8), RASA1(30), RELA(6), SHC1(7), SOS1(13), SYT1(4), VAV1(12), ZAP70(9)	17112318	554	202	424	83	118	164	129	5	121	17	1.09e-08	5.77e-15	6.84e-14
53	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(54), ATR(43), CDC25C(5), CHEK1(2), CHEK2(14), TP53(74), YWHAH(3)	5921097	195	108	164	19	41	59	41	1	49	4	7.38e-05	7.55e-15	8.77e-14
54	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(4), AKT2(6), AKT3(11), BCR(6), BTK(12), CD19(4), CDKN2A(2), DAPP1(9), FLOT1(1), FLOT2(2), GAB1(8), ITPR1(36), ITPR2(35), ITPR3(21), LYN(9), NR0B2(2), PDK1(2), PHF11(5), PIK3CA(172), PITX2(12), PLCG2(29), PPP1R13B(9), PREX1(25), PTEN(228), PTPRC(17), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SAG(10), SYK(4), TEC(8), VAV1(12)	20146159	740	212	541	129	148	231	144	38	150	29	9.48e-10	9.91e-14	1.13e-12
55	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(54), CDC25A(8), CDC25B(3), CDC25C(5), CDK2(2), CDK4(3), CHEK1(2), MYT1(18), RB1(26), TP53(74), WEE1(2), YWHAH(3)	6552026	200	105	170	24	53	59	41	1	40	6	2.93e-05	9.14e-12	1.02e-10
56	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(7), APOA1(3), APOA2(2), CD36(8), CPT1B(6), CREBBP(32), DUSP1(2), EHHADH(11), EP300(32), FABP1(4), HSD17B4(13), INS(3), JUN(1), LPL(16), MAPK1(2), MAPK3(3), ME1(12), MRPL11(1), MYC(8), NCOA1(19), NCOR1(23), NCOR2(23), NFKBIA(3), NR0B2(2), NR1H3(4), NR2F1(7), NRIP1(17), PDGFA(3), PIK3CA(172), PIK3R1(100), PPARA(1), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PTGS2(9), RB1(26), RELA(6), RXRA(3), SP1(7), SRA1(1), STAT5A(5), STAT5B(7)	22410854	641	204	514	103	136	194	160	8	122	21	1.22e-09	9.67e-11	1.06e-09
57	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(4), ASAH1(7), ATF1(6), BRAF(10), CAMP(1), CREB1(6), CREB5(5), CREBBP(32), CRKL(6), DAG1(6), EGR1(6), EGR2(6), EGR3(7), EGR4(5), ELK1(3), FRS2(5), GNAQ(3), JUN(1), MAP1B(35), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5), NTRK1(13), OPN1LW(6), PIK3C2G(16), PIK3CA(172), PIK3CD(12), PIK3R1(100), PTPN11(8), RPS6KA3(19), SHC1(7), SRC(3), TERF2IP(2), TH(3)	18159846	572	205	447	103	130	184	126	5	109	18	1.50e-07	1.40e-08	1.52e-07
58	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(17), ATM(54), ATR(43), BAI1(10), BAX(3), BID(2), CASP3(4), CASP8(21), CASP9(3), CCNB1(8), CCNB2(5), CCNB3(33), CCND1(15), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNG1(9), CCNG2(2), CD82(5), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(14), CYCS(2), DDB2(6), EI24(3), FAS(9), GADD45G(1), GTSE1(2), IGF1(5), IGFBP3(4), MDM2(4), MDM4(5), PERP(3), PMAIP1(1), PPM1D(13), PTEN(228), RCHY1(5), RFWD2(4), RRM2(7), RRM2B(5), SERPINB5(1), SERPINE1(5), SESN1(5), SESN2(3), SESN3(15), SIAH1(6), STEAP3(9), THBS1(11), TNFRSF10B(5), TP53(74), TP53I3(4), TP73(6), TSC2(15), ZMAT3(11)	23077507	765	226	630	133	133	228	131	34	205	34	1.17e-07	7.44e-08	7.91e-07
59	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(4), AKT2(6), AKT3(11), BRAF(10), CAB39(6), DDIT4(2), EIF4B(7), FIGF(5), HIF1A(16), IGF1(5), INS(3), MAPK1(2), MAPK3(3), PDPK1(3), PGF(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PRKAA1(8), PRKAA2(10), RHEB(3), RICTOR(21), RPS6(7), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA6(19), RPS6KB1(5), RPS6KB2(4), STK11(2), TSC1(13), TSC2(15), ULK1(5), ULK2(12), ULK3(5), VEGFA(2), VEGFB(2), VEGFC(6)	18585019	609	207	479	97	139	179	150	5	121	15	4.41e-08	2.33e-07	2.43e-06
60	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(4), AKT2(6), AKT3(11), BAD(2), BCL2L1(4), CDC42(4), CDK2(2), CDKN1B(7), CDKN2A(2), CREB1(6), CREB5(5), EBP(2), ERBB4(27), F2RL2(2), GAB1(8), GRB2(3), GSK3A(10), GSK3B(13), IGF1(5), IGFBP1(4), INPPL1(19), IRS1(13), IRS4(21), MET(17), MYC(8), NOLC1(14), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PARD3(19), PDK1(2), PIK3CA(172), PIK3CD(12), PPP1R13B(9), PREX1(25), PTEN(228), PTK2(12), PTPN1(5), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KB1(5), SHC1(7), SLC2A4(9), SOS1(13), SOS2(17), TSC1(13), TSC2(15), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	26909150	864	216	660	148	189	253	185	41	166	30	1.45e-11	9.36e-07	9.61e-06
61	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(6), ACTR3(1), AKT1(4), AKT2(6), AKT3(11), ANGPTL2(6), ARHGAP1(2), ARHGAP4(11), ARHGEF11(20), BTK(12), CDC42(4), CFL1(1), CFL2(8), GDI1(4), GDI2(1), INPPL1(19), ITPR1(36), ITPR2(35), ITPR3(21), LIMK1(8), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3CG(23), PIK3R1(100), PITX2(12), PPP1R13B(9), PTEN(228), RACGAP1(9), RHO(4), ROCK1(22), ROCK2(17), RPS4X(1), SAG(10), WASF1(3), WASL(9)	25475732	907	219	684	159	175	270	164	38	216	44	4.16e-09	1.79e-06	1.81e-05
62	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(17), ATM(54), BAX(3), CCND1(15), CCNE1(6), CDK2(2), CDK4(3), CDKN1A(1), E2F1(9), MDM2(4), PCNA(3), RB1(26), TIMP3(9), TP53(74)	6638149	226	117	195	34	48	71	52	1	48	6	0.000316	8.92e-06	8.86e-05
63	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(56), AXIN1(9), BTRC(14), CCND1(15), CREBBP(32), CSNK1A1(4), CSNK1D(3), CSNK2A1(9), CTBP1(1), CTNNB1(80), DVL1(3), FZD1(3), GSK3B(13), HDAC1(5), MAP3K7(9), MYC(8), NLK(5), PPARD(3), PPP2CA(6), TLE1(13), WIF1(5), WNT1(1)	10502166	297	132	230	50	65	138	47	2	41	4	1.04e-05	3.97e-05	0.000388
64	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(32), DAXX(10), HRAS(1), PAX3(5), PML(8), RARA(2), RB1(26), SIRT1(6), SP100(20), TNFRSF1A(4), TNFRSF1B(2), TP53(74)	6641355	190	99	162	31	59	55	34	2	36	4	9.65e-05	9.22e-05	0.000887
65	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(6), CDK2(2), CUL1(13), E2F1(9), FBXW7(46), RB1(26), TFDP1(13)	3092136	115	60	97	18	45	31	17	1	17	4	0.000440	0.000115	0.00109
66	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(54), ATR(43), BRCA1(17), BRCA2(58), CHEK1(2), CHEK2(14), FANCA(15), FANCC(9), FANCD2(11), FANCE(9), FANCF(1), FANCG(10), HUS1(3), MRE11A(10), RAD1(6), RAD17(13), RAD50(18), RAD51(2), RAD9A(2), TP53(74)	16271430	371	123	336	46	75	148	72	1	69	6	2.57e-07	0.000502	0.00469
67	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(6), ACTR3(1), AKT1(4), ANGPTL2(6), DAG1(6), DGKA(10), ETFA(5), GCA(2), ITGA9(16), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), MAP2K1(2), MAPK1(2), MAPK3(3), NR1I3(6), PAK1(3), PDE3A(19), PDE3B(15), PI3(2), PIK3C2G(16), PIK3CA(172), PIK3CD(12), PIK3R1(100), PLDN(3), PSME1(1), RIPK3(5), RPS4X(1), SGCB(4), VASP(3)	17891218	530	204	407	104	113	164	121	6	110	16	9.09e-05	0.000946	0.00870
68	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(4), AKT2(6), AKT3(11), CISH(2), GRB2(3), IARS(8), IL13RA1(13), IL2RG(13), IL4(1), IL4R(6), INPP5D(9), JAK1(20), JAK2(17), JAK3(10), NR0B2(2), PI3(2), PIK3CA(172), PPP1R13B(9), RPS6KB1(5), SERPINA4(4), SHC1(7), SOS1(13), SOS2(17), SRC(3), STAT6(10), TYK2(10)	13260226	377	155	276	71	79	142	111	6	35	4	5.74e-05	0.00768	0.0695
69	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(4), APC(56), AR(14), ASAH1(7), BRAF(10), CAMP(1), CCL13(2), CCL15(1), CCL16(1), DAG1(6), EGFR(12), GNA11(2), GNA15(2), GNAI1(5), GNAQ(3), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), MAPK10(9), MAPK14(4), PHKA2(21), PIK3CA(172), PIK3CD(12), PIK3R1(100), PITX2(12), PTX3(2), RAF1(8), SRC(3)	19350915	596	210	468	121	123	197	131	7	117	21	3.65e-05	0.0119	0.106
70	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(5), IMPA1(4), IMPA2(6), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPP5B(5), INPP5E(1), INPPL1(19), IPMK(4), ISYNA1(2), ITPK1(4), ITPKA(1), ITPKB(12), MINPP1(3), MIOX(6), OCRL(19), PI4KA(18), PI4KB(9), PIK3C3(14), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCD3(3), PLCD4(11), PLCE1(41), PLCG1(12), PLCG2(29), PLCZ1(14), PTEN(228), PTPMT1(2), SYNJ1(29), SYNJ2(11)	26523385	862	213	660	167	206	234	181	41	172	28	1.50e-08	0.0231	0.204
71	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(4), AKT2(6), AKT3(11), BAD(2), BCR(6), BLNK(4), BTK(12), CD19(4), CSK(1), DAG1(6), EPHB2(12), GRB2(3), ITPKA(1), ITPKB(12), LYN(9), MAP2K1(2), MAP2K2(5), MAPK1(2), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), PI3(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PLCG2(29), PPP1R13B(9), RAF1(8), SERPINA4(4), SHC1(7), SOS1(13), SOS2(17), SYK(4), VAV1(12)	18448082	538	202	411	109	121	170	128	6	97	16	0.000226	0.0288	0.250
72	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(8), ATM(54), ATR(43), CCNA1(5), CCND1(15), CCNE1(6), CDC25A(8), CDK2(2), CDK4(3), CDK6(3), CDKN1A(1), CDKN1B(7), CDKN2A(2), DHFR(5), E2F1(9), GSK3B(13), HDAC1(5), RB1(26), SKP2(7), TFDP1(13), TGFB1(2), TGFB2(5), TGFB3(9), TP53(74)	10840158	325	137	290	65	82	99	61	1	75	7	0.00408	0.103	0.881
73	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(14), AKT1(4), AKT2(6), AKT3(11), APAF1(17), ATM(54), BAD(2), BAX(3), BCL2L1(4), BID(2), BIRC2(10), BIRC3(5), CAPN1(5), CAPN2(11), CASP10(8), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CFLAR(6), CHUK(8), CSF2RB(14), CYCS(2), DFFB(4), ENDOG(1), FADD(1), FAS(9), FASLG(7), IKBKB(13), IKBKG(4), IL1B(2), IL1R1(5), IL1RAP(8), IL3(2), IL3RA(9), IRAK1(4), IRAK2(9), IRAK3(10), IRAK4(7), MAP3K14(6), MYD88(3), NFKB1(10), NFKB2(9), NFKBIA(3), NTRK1(13), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RELA(6), RIPK1(9), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFRSF1A(4), TNFSF10(1), TP53(74), TRAF2(3)	30167075	880	230	720	163	185	298	188	7	182	20	1.44e-08	0.136	1.000
74	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(3)	187727	3	3	3	1	0	1	0	1	1	0	0.806	0.213	1.000
75	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(5), IL8(3), SLPI(2)	572860	10	10	9	0	2	5	2	0	1	0	0.0567	0.276	1.000
76	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(8)	264662	8	6	8	1	2	4	2	0	0	0	0.297	0.352	1.000
77	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(8), ATM(54), BRCA1(17), CDKN1A(1), CHEK1(2), CHEK2(14), JUN(1), MAPK8(10), MDM2(4), MRE11A(10), NFKB1(10), NFKBIA(3), RAD50(18), RAD51(2), RBBP8(11), RELA(6), TP53(74), TP73(6)	10702357	251	112	223	46	54	85	53	1	54	4	0.00714	0.437	1.000
78	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(6), CD3E(2), CD3G(3)	433293	11	7	11	1	1	7	0	0	3	0	0.181	0.438	1.000
79	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(5), IFNG(9), IFNGR1(5), IFNGR2(4), IKBKB(13), JAK2(17), LIN7A(8), NFKB1(10), NFKBIA(3), RB1(26), RELA(6), TNFRSF1A(4), TNFRSF1B(2), TP53(74), USH1C(13), WT1(3)	6411700	202	96	177	43	54	65	39	2	35	7	0.0119	0.461	1.000
80	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(6), CSF1(6), IL6(5), LDLR(6), LPL(16)	1914084	39	23	39	7	10	15	9	0	5	0	0.0571	0.463	1.000
81	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(5), CCNA2(7), CCND1(15), CCNE1(6), CCNE2(8), CDK2(2), CDK4(3), CDKN1B(7), CDKN2A(2), E2F1(9), E2F2(3), E2F4(3), PRB1(2)	3060313	72	44	70	15	11	26	22	0	13	0	0.115	0.481	1.000
82	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(1), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD58(2), CD8A(2), CSF3(1), IL3(2), IL6(5), IL8(3), KITLG(3)	2309359	40	27	40	9	6	20	4	0	10	0	0.179	0.489	1.000
83	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(4), APAF1(17), ATM(54), BAD(2), BAX(3), BCL2L1(4), BID(2), CASP3(4), CASP6(7), CASP7(4), CASP9(3), CYCS(2), EIF2S1(2), PRKCA(10), PTK2(12), PXN(6), STAT1(15), TLN1(23), TP53(74)	10101713	248	114	219	46	64	79	55	1	46	3	0.00120	0.493	1.000
84	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(6), GSTZ1(5), HGD(4)	822142	15	12	15	2	5	4	4	0	2	0	0.107	0.510	1.000
85	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(6), TPI1(2)	582980	8	7	8	1	0	3	1	0	4	0	0.273	0.570	1.000
86	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(11), APC(56), AXIN1(9), BTRC(14), CTNNB1(80), DLL1(7), DVL1(3), FZD1(3), GSK3B(13), NOTCH1(11), PSEN1(5), WNT1(1)	6996633	213	110	154	51	40	113	31	2	24	3	0.0242	0.583	1.000
87	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(4), AKT2(6), AKT3(11), BTK(12), CSF2(1), FCER1A(9), FCER1G(2), FYN(7), GAB2(10), GRB2(3), HRAS(1), IL3(2), IL4(1), IL5(2), INPP5D(9), KRAS(53), LCP2(5), LYN(9), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), MAPK9(5), MS4A2(3), NRAS(9), PDK1(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCG1(12), PLCG2(29), PRKCA(10), PRKCD(5), PRKCE(10), RAC1(1), RAC2(3), RAF1(8), SOS1(13), SOS2(17), SYK(4), VAV1(12), VAV2(7), VAV3(14)	25702425	781	210	601	156	185	271	173	9	126	17	8.51e-07	0.585	1.000
88	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(4), AKT2(6), AKT3(11), BAD(2), CASP9(3), CDC42(4), HRAS(1), KDR(26), KRAS(53), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPKAPK2(6), MAPKAPK3(5), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NOS3(11), NRAS(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCG1(12), PLCG2(29), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKCA(10), PRKCG(8), PTGS2(9), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAF1(8), SH2D2A(2), SHC2(5), SPHK1(2), SPHK2(2), SRC(3), VEGFA(2)	25185120	753	210	576	157	189	256	164	8	121	15	1.81e-06	0.594	1.000
89	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(9), GOT2(3), TAT(7)	959929	19	13	19	2	7	6	5	1	0	0	0.0879	0.638	1.000
90	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT1(4), AKT2(6), AKT3(11), BCL10(3), BLNK(4), BTK(12), CARD11(22), CD19(4), CD22(14), CD72(1), CD79A(1), CD79B(2), CHUK(8), CR2(24), FCGR2B(3), FOS(3), GSK3B(13), HRAS(1), IKBKB(13), IKBKG(4), INPP5D(9), JUN(1), KRAS(53), LILRB3(4), LYN(9), MALT1(4), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NRAS(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG2(29), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PTPN6(6), RAC1(1), RAC2(3), RASGRP3(13), SYK(4), VAV1(12), VAV2(7), VAV3(14)	26552098	787	208	613	160	182	285	167	7	130	16	4.22e-07	0.646	1.000
91	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(4), AKT2(6), AKT3(11), CASP8(21), CCL4(5), CCL5(2), CD14(2), CD40(4), CD80(5), CD86(5), CHUK(8), CXCL10(2), CXCL9(2), FADD(1), FOS(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IKBKB(13), IKBKE(4), IKBKG(4), IL12A(5), IL12B(2), IL1B(2), IL6(5), IL8(3), IRAK1(4), IRAK4(7), IRF3(2), IRF5(8), IRF7(1), JUN(1), LBP(3), LY96(4), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K7(9), MAP3K8(10), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), MAPK9(5), MYD88(3), NFKB1(10), NFKB2(9), NFKBIA(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), RAC1(1), RELA(6), RIPK1(9), SPP1(2), STAT1(15), TBK1(7), TICAM1(7), TIRAP(2), TLR1(15), TLR2(16), TLR3(10), TLR4(17), TLR5(14), TLR6(14), TLR7(17), TLR8(19), TLR9(6), TOLLIP(1), TRAF3(5), TRAF6(7)	31810954	866	209	732	170	201	289	197	5	156	18	5.19e-08	0.681	1.000
92	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(6), LPL(16), NR3C1(18), PPARG(6), RETN(1), RXRA(3)	1931315	50	24	49	9	12	20	7	1	10	0	0.0290	0.695	1.000
93	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(6), ACAT2(4), HMGCL(2), OXCT1(10)	1250166	22	15	21	3	8	8	3	0	3	0	0.118	0.699	1.000
94	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(19), BMPR1A(5), BMPR1B(6), BMPR2(12)	2246825	42	24	42	6	13	15	7	2	5	0	0.0541	0.702	1.000
95	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(9), GOT1(9), GOT2(3), TAT(7), TYR(12)	1718364	40	20	40	5	11	13	12	1	3	0	0.0253	0.710	1.000
96	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(6), CDK2(2), CDKN1B(7), CKS1B(1), CUL1(13), E2F1(9), RB1(26), RBX1(1), SKP2(7), TFDP1(13)	3169643	85	39	83	18	27	25	17	0	13	3	0.0433	0.732	1.000
97	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(11), APC(56), ATF2(8), AXIN1(9), BMP10(9), BMP2(6), BMP4(10), BMP5(14), BMP7(12), BMPR1A(5), BMPR2(12), CHRD(11), CTNNB1(80), DVL1(3), FZD1(3), GATA4(3), GSK3B(13), MAP3K7(9), MEF2C(11), MYL2(2), NKX2-5(2), NOG(2), NPPA(2), NPPB(3), RFC1(21), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TGFBR3(15), WNT1(1)	12863550	360	130	295	73	92	170	54	3	38	3	0.000196	0.760	1.000
98	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(6), ALDOA(5), ALDOB(9), ALDOC(3), TPI1(2)	1409129	25	16	24	4	8	5	5	0	7	0	0.0994	0.788	1.000
99	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(6), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6)	1210424	26	16	26	6	3	16	0	0	7	0	0.263	0.789	1.000
100	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(5), ASPH(13), COPS5(5), CREB1(6), EDN1(4), EP300(32), EPO(2), HIF1A(16), JUN(1), LDHA(8), NOS3(11), P4HB(6), VHL(3)	6084806	112	46	111	16	32	32	26	2	20	0	0.000561	0.862	1.000
101	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6)	2104861	40	20	40	6	13	11	9	0	7	0	0.0192	0.881	1.000
102	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(8), SUCLA2(5)	775051	13	10	11	3	8	3	0	0	2	0	0.299	0.881	1.000
103	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(6), FOS(3), FXYD2(3), JUN(1), KEAP1(8), MAFK(1), MAPK1(2), MAPK14(4), MAPK8(10), NFE2L2(15), PRKCA(10)	3125025	63	38	60	13	18	16	16	3	10	0	0.0513	0.892	1.000
104	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(2), CCR3(4), CSF2(1), HLA-DRA(1), IL3(2), IL5(2)	970363	12	11	12	1	3	4	2	0	3	0	0.0945	0.899	1.000
105	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(5), RAB11A(2), RAB1A(5), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(2), RAB6A(1), RAB9A(6)	1589158	32	17	30	9	13	8	5	0	6	0	0.228	0.907	1.000
106	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(8), IDI1(3), SQLE(5)	1213914	17	12	17	2	4	8	4	0	1	0	0.167	0.915	1.000
107	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), HSD3B7(5), PON1(12), PON2(6), PON3(5), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	3235853	60	31	58	11	19	22	10	1	8	0	0.0142	0.917	1.000
108	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(8), IFNG(9), IL12A(5), IL12B(2), IL18(2), IL2(2)	1135018	28	20	27	8	9	9	6	1	3	0	0.506	0.921	1.000
109	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(7), COASY(11), DPYD(20), DPYS(6), ENPP1(12), ENPP3(18), PANK1(3), PANK2(7), PANK3(5), PANK4(5), PPCS(5), UPB1(10)	4910957	109	38	108	21	27	44	26	0	12	0	0.0107	0.937	1.000
110	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(5), CCNE1(6), CDK2(2), CUL1(13), E2F1(9), RB1(26), SKP2(7), TFDP1(13)	3172824	81	39	79	19	28	21	17	0	12	3	0.0698	0.939	1.000
111	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(4), CD4(6), HLA-DRA(1), IL1B(2), IL4(1), IL5(2), IL5RA(9), IL6(5)	1844183	30	21	28	8	4	13	3	0	10	0	0.280	0.947	1.000
112	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(54), ATR(43), BRCA1(17), CCNB1(8), CDC25A(8), CDC25B(3), CDC25C(5), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(14), EP300(32), MDM2(4), MYT1(18), PRKDC(54), RPS6KA1(1), TP53(74), WEE1(2), YWHAH(3), YWHAQ(1)	15904811	345	124	309	64	73	103	83	4	78	4	0.00130	0.963	1.000
113	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(17), BAK1(3), BAX(3), BCL2L1(4), BID(2), BIRC2(10), BIRC3(5), CASP2(6), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CYCS(2), FADD(1), FAS(9), FASLG(7), GZMB(4), IKBKG(4), JUN(1), MAP2K4(9), MAP3K1(30), MAP3K14(6), MAPK10(9), MCL1(1), MDM2(4), MYC(8), NFKB1(10), NFKBIA(3), PARP1(9), PRF1(8), RELA(6), RIPK1(9), TNFRSF1A(4), TNFRSF1B(2), TNFSF10(1), TP53(74), TRAF1(5), TRAF2(3)	13320502	318	118	287	66	76	108	70	3	59	2	0.000680	0.964	1.000
114	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(2), FOSB(4), GRIA2(20), PPP1R1B(2)	1282432	28	17	27	8	8	7	6	0	6	1	0.337	0.966	1.000
115	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(5), BIRC3(5), CASP8(21), FADD(1), RIPK1(9), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3)	2704555	50	30	48	12	10	18	9	0	13	0	0.188	0.976	1.000
116	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP1(2), RANBP2(40), RANGAP1(3)	3100037	46	23	46	8	10	18	10	0	8	0	0.159	0.977	1.000
117	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(14), GABRA2(14), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(7), PRKCE(10), SOD1(2)	2901805	90	35	85	27	23	35	19	0	13	0	0.250	0.980	1.000
118	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(8), CDC25B(3), CDK7(7), CDKN1A(1), CHEK1(2), NEK1(19), WEE1(2)	2797504	42	22	40	7	14	17	5	0	6	0	0.159	0.982	1.000
119	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GBA3(9), GGT1(5), SHMT1(5), SHMT2(5)	1518951	25	17	25	5	9	9	3	0	4	0	0.108	0.982	1.000
120	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(7), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFB7(3), NDUFS1(13), NDUFS2(7), NDUFV1(3), NDUFV2(2)	2599039	46	28	45	9	18	16	6	1	4	1	0.122	0.982	1.000
121	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(8), ACTN1(9), ACTR2(6), ACTR3(1), AKT1(4), AKT2(6), AKT3(11), ANGPTL2(6), ARHGEF6(26), ARHGEF7(15), BCAR1(8), BRAF(10), CAV1(2), CDC42(4), CDKN2A(2), CRK(2), CSE1L(14), DOCK1(24), EPHB2(12), FYN(7), GRB2(3), GRB7(5), ILK(5), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGB3BP(3), MAP2K4(9), MAP2K7(4), MAP3K11(6), MAPK1(2), MAPK10(9), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5), MRAS(1), MYLK(14), MYLK2(8), P4HB(6), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PIK3CA(172), PIK3CB(17), PKLR(7), PLCG1(12), PLCG2(29), PTEN(228), PTK2(12), RAF1(8), RALA(6), RHO(4), ROCK1(22), ROCK2(17), SHC1(7), SOS1(13), SOS2(17), SRC(3), TERF2IP(2), TLN1(23), TLN2(29), VASP(3), WAS(11), ZYX(11)	44169711	1112	215	897	234	265	338	230	39	208	32	4.15e-09	0.983	1.000
122	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(8), ABL2(22), AKT1(4), AKT2(6), AKT3(11), ARAF(12), AREG(1), BAD(2), BRAF(10), BTC(2), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CBL(12), CBLB(12), CBLC(5), CDKN1A(1), CDKN1B(7), CRK(2), CRKL(6), EGF(20), EGFR(12), ELK1(3), ERBB2(10), ERBB3(20), ERBB4(27), EREG(3), GAB1(8), GRB2(3), GSK3B(13), HBEGF(2), HRAS(1), JUN(1), KRAS(53), MAP2K1(2), MAP2K2(5), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK9(5), MYC(8), NCK1(4), NCK2(8), NRAS(9), NRG1(27), NRG2(4), NRG3(17), NRG4(1), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(29), PRKCA(10), PRKCG(8), PTK2(12), RAF1(8), RPS6KB1(5), RPS6KB2(4), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SRC(3), STAT5A(5), STAT5B(7)	36621303	999	215	817	206	252	351	214	7	156	19	4.86e-08	0.985	1.000
123	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(4), AKT2(6), AKT3(11), BAD(2), BCR(6), BLNK(4), BTK(12), CD19(4), CD22(14), CR2(24), CSK(1), DAG1(6), FLOT1(1), FLOT2(2), GRB2(3), GSK3A(10), GSK3B(13), INPP5D(9), ITPR1(36), ITPR2(35), ITPR3(21), LYN(9), MAP4K1(11), MAPK1(2), MAPK3(3), NFATC1(10), NFATC2(13), NR0B2(2), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(100), PLCG2(29), PPP1R13B(9), PPP3CA(4), PPP3CB(5), PPP3CC(6), PTPRC(17), RAF1(8), SHC1(7), SOS1(13), SOS2(17), SYK(4), VAV1(12)	26363173	691	203	560	153	170	228	155	8	113	17	8.68e-05	0.991	1.000
124	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(54), CDC25A(8), CDC25B(3), CDC25C(5), CHEK1(2), MYT1(18), WEE1(2), YWHAH(3)	5100102	95	37	90	16	22	34	18	0	18	3	0.0368	0.992	1.000
125	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(7), PGLYRP2(5)	631323	12	10	11	7	2	6	1	0	3	0	0.945	0.992	1.000
126	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(3), CD4(6), HLA-DRA(1)	743572	10	10	10	4	3	4	0	0	3	0	0.743	0.993	1.000
127	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(9), ENO1(6), GPI(7), HK1(11), PFKL(8), PGAM1(3), PGK1(7), PKLR(7), TPI1(2)	3222973	60	30	59	13	23	20	8	0	9	0	0.0304	0.994	1.000
128	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(5)	748071	11	8	11	5	3	6	0	0	2	0	0.869	0.996	1.000
129	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(32), EP300(32), LPL(16), NCOA1(19), NCOA2(15), PPARG(6), RXRA(3)	6718199	123	50	119	26	31	36	31	2	22	1	0.0251	0.997	1.000
130	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(10), CLOCK(9), CRY1(9), CRY2(3), CSNK1E(3), PER1(10)	3037182	44	25	43	9	13	16	7	1	7	0	0.156	0.997	1.000
131	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(3), FOSL1(3), FOSL2(7), IFNAR1(7), IFNAR2(8), IFNB1(3), MAPK8(10), NFKB1(10), RELA(6), TNFRSF11A(4), TNFSF11(7), TRAF6(7)	3947890	75	31	73	14	19	26	22	0	8	0	0.0289	0.997	1.000
132	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(7), F13A1(8), F2(8), F2R(6), FGA(26), FGB(7), FGG(10), PLAT(6), PLAU(6), PLG(14), SERPINB2(9), SERPINE1(5)	4979506	112	38	108	25	24	51	25	1	11	0	0.0372	0.997	1.000
133	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL12A(5), IL12B(2), IL15(2), IL16(17), IL18(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL8(3), IL9(1), LTA(3)	3525903	64	27	63	18	16	27	12	1	8	0	0.191	0.998	1.000
134	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(6), CBS(11), CTH(6), MUT(10)	1755891	36	22	35	9	10	16	6	0	4	0	0.259	0.998	1.000
135	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(3), LIPT1(5)	566294	8	7	8	4	2	3	2	0	1	0	0.924	0.998	1.000
136	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(32), EP300(32), ESR1(11), MAPK1(2), MAPK3(3), PELP1(11), SRC(3)	5444727	94	47	89	21	26	24	25	1	17	1	0.0704	0.999	1.000
137	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(32), AKT1(4), ATM(54), BAX(3), CDKN1A(1), CPB2(7), CSNK1A1(4), CSNK1D(3), FHL2(2), HIF1A(16), IGFBP3(4), MAPK8(10), MDM2(4), NFKBIB(1), NQO1(3), TP53(74)	7267170	222	112	192	48	54	68	49	2	44	5	0.0617	0.999	1.000
138	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(18), CD38(6), ENPP1(12), ENPP3(18), NADSYN1(6), NMNAT1(3), NMNAT2(3), NNMT(6), NNT(7), NT5C(1), NT5E(6), NT5M(3), QPRT(2)	5305520	91	31	89	19	23	37	28	0	3	0	0.0188	0.999	1.000
139	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(9), GAD1(6), HDC(9), PNMT(2), TH(3), TPH1(9)	2023477	38	23	37	10	14	11	8	0	4	1	0.202	0.999	1.000
140	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(6), GSS(5), IL8(3), NFKB1(10), NOX1(16), RELA(6), SOD1(2), XDH(14)	3588806	62	26	62	13	16	22	14	1	9	0	0.0740	0.999	1.000
141	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	6	B3GNT1(5), FUT1(4), FUT2(1), FUT9(9), GCNT2(11), ST8SIA1(2)	1973787	32	18	32	8	16	11	5	0	0	0	0.116	0.999	1.000
142	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(7), BFAR(7), BRAF(10), CAMP(1), CREB1(6), CREB5(5), MAPK1(2), RAF1(8), SNX13(15), SRC(3), TERF2IP(2)	4244786	66	28	65	15	14	27	14	1	10	0	0.203	0.999	1.000
143	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(9), NFYB(2), NFYC(3), RB1(26), SP1(7), SP3(11)	2477280	58	27	55	11	17	14	14	0	10	3	0.131	0.999	1.000
144	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(5), GLS(11), GLUD1(3), OAT(7), PRODH(12)	2002359	42	22	39	11	13	13	8	1	7	0	0.257	1.000	1.000
145	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(6), DCN(11), FMOD(5), KERA(10), LUM(13)	1337449	45	20	41	12	15	18	7	0	5	0	0.226	1.000	1.000
146	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(5), CCNB1(8), CCND1(15), CCND2(9), CCND3(4), CCNE1(6), CCNH(7), CDC25A(8), CDK2(2), CDK4(3), CDK6(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(2), CDKN2C(4), CDKN2D(1), E2F1(9), RB1(26), RBL1(14), TFDP1(13)	5680949	154	56	148	31	46	42	32	0	31	3	0.00882	1.000	1.000
147	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CAMKK1(13), CAMKK2(7), CREB1(6), SYT1(4)	4149292	70	29	68	15	26	26	9	0	9	0	0.0268	1.000	1.000
148	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(20), EGFR(12), ERBB3(20), NRG1(27)	3749909	79	35	76	17	23	30	16	0	10	0	0.105	1.000	1.000
149	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(4), GPLD1(13), PGAP1(17), PIGA(8), PIGB(11), PIGC(3), PIGF(2), PIGG(6), PIGH(5), PIGK(9), PIGL(1), PIGM(1), PIGN(13), PIGO(9), PIGP(3), PIGQ(5), PIGS(1), PIGT(7), PIGU(3), PIGV(7), PIGW(9), PIGX(2), PIGZ(5)	8968278	144	49	141	28	36	57	35	0	16	0	0.00262	1.000	1.000
150	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(7), IFNAR2(8), IFNB1(3), JAK1(20), STAT1(15), STAT2(8), TYK2(10)	3919832	73	30	71	20	21	21	21	0	10	0	0.256	1.000	1.000
151	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(8), CCNH(7), CDC25A(8), CDC25B(3), CDC25C(5), CDK7(7), SHH(4), XPO1(18)	3154343	60	25	57	12	24	15	14	0	7	0	0.0956	1.000	1.000
152	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(5), ASL(2), CPS1(23), GLS(11), GLUD1(3), GOT1(9)	2808232	53	22	52	12	12	22	8	1	8	2	0.216	1.000	1.000
153	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(4), SRP19(3), SRP54(8), SRP68(5), SRP72(11), SRP9(1), SRPR(11)	2776480	44	21	44	9	10	22	6	0	6	0	0.246	1.000	1.000
154	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(6), ENO2(4), ENO3(5), FARS2(2), GOT1(9), GOT2(3), PAH(2), TAT(7), YARS(5)	3043413	43	21	43	10	15	14	10	1	3	0	0.175	1.000	1.000
155	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(6), CD8A(2), CSF1(6), CSF2(1), CSF3(1), EPO(2), IL11(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL7(1), IL8(3), IL9(1)	2235970	37	29	37	12	10	16	4	1	6	0	0.395	1.000	1.000
156	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	B3GNT1(5), B3GNT2(1), B3GNT3(5), B3GNT4(4), B3GNT5(6), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), FUT7(2), FUT9(9), GCNT2(11), ST3GAL6(6), ST8SIA1(2)	5116187	97	36	96	21	42	33	12	1	9	0	0.0119	1.000	1.000
157	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(1), CSF3(1), EPO(2), FLT3(16), IGF1(5), IL11(2), IL3(2), IL6(5), IL9(1), KITLG(3), TGFB1(2), TGFB2(5), TGFB3(9)	3069442	54	28	52	13	14	23	10	0	7	0	0.158	1.000	1.000
158	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(8), GGPS1(2), IDI1(3), IDI2(1), SQLE(5)	1613940	20	13	20	5	5	10	4	0	1	0	0.474	1.000	1.000
159	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(56), AXIN1(9), CREBBP(32), CTNNB1(80), DVL1(3), EP300(32), FZD1(3), GSK3B(13), HDAC1(5), LDB1(5), LEF1(9), PITX2(12), TRRAP(42), WNT1(1)	11871781	302	125	238	76	62	134	53	4	44	5	0.0220	1.000	1.000
160	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(4), ANKRD1(7), ATF3(3), CYR61(3), DUSP14(4), EIF4E(2), HBEGF(2), IFNG(9), IFRD1(6), IL18(2), IL1R1(5), MYOG(1), NR4A3(9), WDR1(10)	3908198	67	27	67	16	17	27	14	0	9	0	0.190	1.000	1.000
161	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(17), ARHGAP5(21), ARHGDIB(3), CASP1(8), CASP10(8), CASP3(4), CASP8(21), CASP9(3), CYCS(2), GZMB(4), JUN(1), PRF1(8)	4727581	100	34	96	26	21	36	20	0	22	1	0.299	1.000	1.000
162	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(6), NR0B2(2), NR1H3(4), NR1H4(7), RXRA(3)	1864144	25	17	25	7	9	6	4	1	5	0	0.328	1.000	1.000
163	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(6), ACAT2(4), BDH1(3), BDH2(4), HMGCL(2), HMGCS1(6), HMGCS2(9), OXCT1(10), OXCT2(2)	2682095	46	25	45	11	14	19	8	1	4	0	0.203	1.000	1.000
164	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), HEMK1(3), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(5), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), WBSCR22(5)	5308040	89	33	87	20	24	39	9	1	16	0	0.0284	1.000	1.000
165	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(20), JAK2(17), JAK3(10), PIAS1(7), PIAS3(9), PTPRU(19), REG1A(4), SOAT1(9)	5010873	97	37	96	24	29	32	17	1	15	3	0.114	1.000	1.000
166	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(9), IFNGR1(5), JAK1(20), JAK2(17), PTPRU(19), REG1A(4), STAT1(15)	4199450	91	37	90	24	32	26	15	0	15	3	0.205	1.000	1.000
167	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6), ICAM1(2), ITGAL(17), ITGB2(14), PTPRC(17), THY1(1)	4083120	75	36	74	25	22	31	9	1	12	0	0.352	1.000	1.000
168	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(5), IL6R(7), JAK1(20), JAK2(17), JAK3(10), PIAS3(9), PTPRU(19), REG1A(4), SRC(3), STAT3(10)	5492541	106	41	105	28	28	35	21	1	18	3	0.137	1.000	1.000
169	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(14), F2(8), F2R(6), F3(6), F5(48), F7(2), FGA(26), FGB(7), FGG(10), PROC(5), PROS1(21), SERPINC1(10), TFPI(9)	5927459	172	42	164	37	37	86	32	1	15	1	0.0228	1.000	1.000
170	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(6), CD3E(2), CD3G(3), CD4(6), FYN(7), HLA-DRA(1), LCK(5), PTPRC(17), ZAP70(9)	3156865	56	25	56	16	13	24	8	0	11	0	0.326	1.000	1.000
171	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(3), ECHS1(3), HADH(1), HADHA(6), HADHB(4), HSD17B10(4), HSD17B4(13), MECR(6), PPT1(3), PPT2(1)	3035384	44	27	43	11	8	16	15	1	4	0	0.260	1.000	1.000
172	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(6), CHRNA1(7), SNAP25(9), STX1A(1)	1177188	23	15	22	6	14	2	6	0	1	0	0.301	1.000	1.000
173	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(14), FOS(3), GRB2(3), HRAS(1), IL3(2), IL3RA(9), JAK2(17), MAP2K1(2), MAPK3(3), PTPN6(6), RAF1(8), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7)	6359638	100	44	96	26	30	44	20	0	3	3	0.121	1.000	1.000
174	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(17), BAD(2), BAK1(3), BAX(3), BCL10(3), BCL2L1(4), BCL2L11(6), BID(2), CASP9(3), CES1(13)	2783428	56	27	55	13	9	23	16	0	8	0	0.224	1.000	1.000
175	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(5), APAF1(17), CASP3(4), CASP9(3), CYCS(2), DAXX(10), FAS(9), FASLG(7), HSPB2(1), MAPKAPK2(6), MAPKAPK3(5)	3917860	69	27	68	15	15	25	19	0	10	0	0.102	1.000	1.000
176	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD8A(2), ICAM1(2), ITGAL(17), ITGB2(14), PTPRC(17), THY1(1)	3842727	71	32	70	24	23	28	9	1	10	0	0.320	1.000	1.000
177	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(21), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(8), ANAPC7(5), BTRC(14), CDC16(12), CDC20(4), CDC23(7), CUL1(13), CUL2(12), CUL3(14), FBXW11(5), FBXW7(46), FZR1(2), ITCH(10), RBX1(1), SKP2(7), SMURF1(12), SMURF2(7), TCEB1(2), TCEB2(2), UBA1(17), UBE2C(1), UBE2D2(4), UBE2D3(2), UBE2D4(2), UBE2E1(3), UBE2E2(3), UBE2E3(7), VHL(3), WWP1(19), WWP2(9)	14140270	287	91	267	61	94	87	60	2	43	1	0.00550	1.000	1.000
178	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3D(6), CD3E(2), CD3G(3), GZMB(4), HLA-A(1), ICAM1(2), ITGAL(17), ITGB2(14), PRF1(8)	3051150	60	32	58	19	25	22	4	1	8	0	0.127	1.000	1.000
179	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(6), CD3D(6), CD3E(2), CD3G(3), CXCR3(5), ETV5(3), IFNG(9), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18(2), IL18R1(9), JAK2(17), JUN(1), MAP2K6(10), MAPK14(4), MAPK8(10), STAT4(7), TYK2(10)	6885170	134	42	132	31	30	50	32	1	18	3	0.0609	1.000	1.000
180	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(4), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPPL1(19), ITPKA(1), ITPKB(12), MIOX(6), OCRL(19), PIK3C2A(23), PIK3C2B(10), PIK3C2G(16), PIK3CA(172), PIK3CB(17), PIK3CG(23), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCG1(12), PLCG2(29)	16343503	456	162	351	102	131	147	119	5	53	1	0.00136	1.000	1.000
181	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), SHMT1(5)	5607042	107	44	105	29	29	41	13	0	24	0	0.197	1.000	1.000
182	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), SHMT1(5)	5607042	107	44	105	29	29	41	13	0	24	0	0.197	1.000	1.000
183	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), SHMT1(5)	5607042	107	44	105	29	29	41	13	0	24	0	0.197	1.000	1.000
184	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(3), ALAS1(8), ALAS2(11), CPO(3), FECH(7), GATA1(8), HBA1(1), HBA2(1), HBB(2), HMBS(8), UROD(3), UROS(3)	3008529	58	28	56	15	19	23	10	0	6	0	0.216	1.000	1.000
185	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(9), ELK1(3), EPO(2), EPOR(4), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(10), PLCG1(12), PTPN6(6), RAF1(8), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7)	7811814	116	48	109	28	33	48	26	0	6	3	0.0671	1.000	1.000
186	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(21), ADRB2(7), CFTR(14), GNAS(24), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), SLC9A3R1(3)	4521301	96	36	92	26	38	28	15	1	13	1	0.126	1.000	1.000
187	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), FDXR(3), SHMT1(5)	5871170	110	44	108	29	30	41	15	0	24	0	0.157	1.000	1.000
188	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(7), ACOX3(8), FADS2(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9)	3783753	62	33	59	18	25	20	6	2	9	0	0.187	1.000	1.000
189	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(14), AGT(8), AGTR1(4), AGTR2(11), BDKRB2(8), KNG1(12), NOS3(11), REN(4)	3394668	72	29	69	20	31	29	6	1	5	0	0.0733	1.000	1.000
190	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(7), IARS(8), LARS(19), LARS2(8), PDHA1(7), PDHA2(10), PDHB(3)	3714074	62	23	61	15	12	28	12	0	10	0	0.381	1.000	1.000
191	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(6), FARSB(7), GOT1(9), GOT2(3), PAH(2), TAT(7), YARS(5), YARS2(3)	3194444	44	24	44	11	16	14	11	1	2	0	0.240	1.000	1.000
192	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(10), CLOCK(9), CRY1(9), CRY2(3), CSNK1D(3), CSNK1E(3), NPAS2(14), NR1D1(3), PER1(10), PER2(13), PER3(15)	6067688	92	40	88	23	31	32	15	1	13	0	0.0684	1.000	1.000
193	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(3), CD86(5), HLA-DRA(1), IFNG(9), IFNGR1(5), IFNGR2(4), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18(2), IL18R1(9), IL2(2), IL2RA(4), IL4(1), IL4R(6)	4551927	81	33	80	26	27	26	15	1	12	0	0.346	1.000	1.000
194	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(2), CALM2(4), CALML3(3), CALML6(4), CDS1(5), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKI(20), DGKQ(2), DGKZ(10), FN3K(5), IMPA1(4), IMPA2(6), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPP5B(5), INPP5D(9), INPP5E(1), INPPL1(19), ITPK1(4), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), OCRL(19), PI4KA(18), PI4KB(9), PIK3C2A(23), PIK3C2B(10), PIK3C2G(16), PIK3C3(14), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCD3(3), PLCD4(11), PLCE1(41), PLCG1(12), PLCG2(29), PLCZ1(14), PRKCA(10), PRKCG(8), PTEN(228), PTPMT1(2), SYNJ1(29), SYNJ2(11)	45436750	1268	223	1037	288	304	354	258	43	265	44	9.09e-06	1.000	1.000
195	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(4), CASP8(21), CFL1(1), CFLAR(6), PDE6D(2)	1403178	34	19	32	11	4	15	6	0	9	0	0.660	1.000	1.000
196	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(5), CTSD(4), ESR1(11), GREB1(20), HSPB2(1), MTA1(6), MTA3(6), PDZK1(5), TUBA8(7)	3584758	65	39	64	17	21	18	16	3	7	0	0.107	1.000	1.000
197	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(6), IL1B(2), MST1(4), MST1R(12)	2135450	24	17	22	9	11	7	2	0	4	0	0.632	1.000	1.000
198	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19)	4725130	104	33	99	27	21	45	23	0	13	2	0.219	1.000	1.000
199	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(5), COQ5(5), COQ6(4), COQ7(3), NDUFA13(1), NDUFB11(3)	1527536	21	17	21	8	8	8	3	0	2	0	0.729	1.000	1.000
200	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(22), AGT(8), AGTR1(4), AGTR2(11), CMA1(2), COL4A1(21), COL4A2(12), COL4A3(26), COL4A4(24), COL4A5(26), COL4A6(32), REN(4)	9494645	192	49	186	49	41	102	25	3	18	3	0.0496	1.000	1.000
201	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(2), BAX(3), CASP8(21), CYCS(2), FADD(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(10), NFKB1(10), NSMAF(10), RAF1(8), RELA(6), RIPK1(9), SMPD1(11), TNFRSF1A(4), TRAF2(3)	7275526	146	52	141	32	32	52	27	0	34	1	0.0370	1.000	1.000
202	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2)	4869763	71	28	70	21	26	22	13	2	8	0	0.169	1.000	1.000
203	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(9), IFNGR1(5), IFNGR2(4), JAK1(20), JAK2(17), STAT1(15)	3049904	70	32	69	22	19	22	14	0	12	3	0.570	1.000	1.000
204	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(17), BAK1(3), BAX(3), BCL2L1(4), BID(2), BIK(2), BIRC2(10), BIRC3(5), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CYCS(2), DFFB(4), DIABLO(2), ENDOG(1)	4938447	94	33	91	25	15	38	20	0	21	0	0.376	1.000	1.000
205	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), APEX1(2), CREBBP(32), DFFB(4), GZMA(6), GZMB(4), HMGB2(4), NME1(2), PRF1(8), SET(7)	3880986	71	34	67	20	23	23	11	0	13	1	0.221	1.000	1.000
206	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(7), CDO1(4), CSAD(7), GAD1(6), GAD2(12), GGT1(5)	2063029	41	23	41	13	9	13	12	2	5	0	0.442	1.000	1.000
207	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(7), HLCS(6), SPCS3(2)	1133663	15	10	15	9	2	4	8	0	1	0	0.955	1.000	1.000
208	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(12), BID(2), BRAF(10), CASP3(4), CD244(6), CD247(5), CD48(2), CSF2(1), FAS(9), FASLG(7), FCER1G(2), FCGR3A(1), FCGR3B(2), FYN(7), GRB2(3), GZMB(4), HCST(1), HLA-A(1), HLA-B(4), HLA-C(2), HLA-E(1), HLA-G(2), HRAS(1), ICAM1(2), ICAM2(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(9), IFNGR1(5), IFNGR2(4), ITGAL(17), ITGB2(14), KIR2DL1(5), KIR2DL3(1), KIR2DL4(4), KIR3DL1(10), KIR3DL2(5), KLRC1(7), KLRC2(3), KLRC3(1), KLRD1(3), KLRK1(1), KRAS(53), LCK(5), LCP2(5), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MICA(3), MICB(2), NCR1(6), NCR2(3), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NRAS(9), PAK1(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(29), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRF1(8), PRKCA(10), PRKCG(8), PTK2B(16), PTPN11(8), PTPN6(6), RAC1(1), RAC2(3), RAF1(8), SH2D1A(7), SH2D1B(4), SH3BP2(7), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SYK(4), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFSF10(1), TYROBP(1), ULBP1(2), ULBP2(5), ULBP3(2), VAV1(12), VAV2(7), VAV3(14), ZAP70(9)	40242749	1027	212	843	241	253	376	227	8	146	17	9.57e-06	1.000	1.000
209	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(3), TGDS(4), UGDH(2), UGP2(6), UXS1(5)	1872620	21	15	20	9	7	7	5	0	2	0	0.859	1.000	1.000
210	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(21), GNAS(24), GNB1(2), GNGT1(1), PRKACA(6), PRKAR1A(4)	2172411	58	29	56	15	29	14	8	0	7	0	0.211	1.000	1.000
211	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	CNR1(12), CNR2(6), DNMT1(14), MTNR1A(5), MTNR1B(4), PTAFR(4), PTGDR(9), PTGER2(3), PTGER4(12), PTGFR(13), PTGIR(3)	3658357	85	41	82	26	32	33	16	0	4	0	0.0986	1.000	1.000
212	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(5), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), AOX1(18), COMT(3), DBH(9), DCT(13), DDC(9), FAH(6), GOT1(9), GOT2(3), GSTZ1(5), HGD(4), HPD(7), MAOA(12), MAOB(7), PNMT(2), TAT(7), TH(3), TPO(15), TYR(12)	11116639	228	60	219	60	69	75	50	2	32	0	0.0178	1.000	1.000
213	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(5), ACP2(1), ACP5(5), ACPP(5), ACPT(5), ENPP1(12), ENPP3(18), FLAD1(5), RFK(1), TYR(12)	3572293	69	26	69	17	11	27	27	0	4	0	0.278	1.000	1.000
214	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(5), ACP2(1), ACP5(5), ACP6(4), ACPP(5), ACPT(5), ENPP1(12), ENPP3(18), FLAD1(5), LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), PHPT1(1), RFK(1), TYR(12)	5503174	107	34	106	28	19	42	32	0	14	0	0.301	1.000	1.000
215	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(6), CREM(8), FOS(3), JUN(1), MAPK3(3), OPRK1(10), POLR2A(21), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	4652266	79	35	77	23	30	22	15	1	10	1	0.148	1.000	1.000
216	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	9	B3GALT1(12), B3GALT2(8), B3GALT5(4), B3GNT5(6), FUT1(4), FUT2(1), FUT3(8), ST3GAL3(10), ST3GAL4(3)	2404103	56	24	54	16	20	17	10	1	8	0	0.252	1.000	1.000
217	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IL6(5), IL6R(7), IL6ST(11), JAK1(20), JAK2(17), JAK3(10), JUN(1), MAP2K1(2), MAPK3(3), PTPN11(8), RAF1(8), SHC1(7), SOS1(13), SRF(3), STAT3(10)	8536621	144	55	138	34	32	55	35	0	19	3	0.0587	1.000	1.000
218	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(17), EGF(20), EGFR(12), HGS(8), RAB5A(2), TF(14), TFRC(4)	4655220	77	28	75	24	21	28	15	0	13	0	0.446	1.000	1.000
219	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), DCXR(1), GUSB(5), RPE(5), UCHL1(4), UCHL3(1), UGDH(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2B15(9), UGT2B4(11)	6412129	85	31	83	19	21	41	11	1	11	0	0.0766	1.000	1.000
220	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(5), CDKN1A(1), EPO(2), EPOR(4), GRIN1(4), HIF1A(16), JAK2(17), NFKB1(10), NFKBIA(3), RELA(6), SOD2(3)	4546138	71	30	71	20	17	27	15	1	8	3	0.325	1.000	1.000
221	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(8), APOBEC1(7), APOBEC2(4), APOBEC3A(1), APOBEC3B(6), APOBEC3C(4), APOBEC3F(6), APOBEC3G(3), APOBEC4(5)	2713493	44	21	44	12	15	18	9	1	1	0	0.353	1.000	1.000
222	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(7), IFNB1(3), JAK1(20), PTPRU(19), REG1A(4), STAT1(15), STAT2(8), TYK2(10)	4502550	86	34	85	24	34	23	19	0	10	0	0.174	1.000	1.000
223	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(7), BCAT2(3), COASY(11), DPYD(20), DPYS(6), ENPP1(12), ENPP3(18), ILVBL(8), PANK1(3), PANK2(7), PANK3(5), PANK4(5), PPCDC(1), PPCS(5), UPB1(10), VNN1(9)	6157106	130	43	126	32	39	48	30	0	13	0	0.0477	1.000	1.000
224	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT1(4), AKT2(6), AKT3(11), BCL10(3), CARD11(22), CBL(12), CBLB(12), CBLC(5), CD247(5), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD40LG(6), CD8A(2), CD8B(1), CDC42(4), CDK4(3), CHUK(8), CSF2(1), CTLA4(2), FOS(3), FYN(7), GRB2(3), HRAS(1), ICOS(3), IFNG(9), IKBKB(13), IKBKG(4), IL10(3), IL2(2), IL4(1), IL5(2), ITK(7), JUN(1), KRAS(53), LCK(5), LCP2(5), MALT1(4), MAP3K14(6), MAP3K8(10), NCK1(4), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NRAS(9), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PDCD1(3), PDK1(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKCQ(9), PTPN6(6), PTPRC(17), RASGRP1(8), RHOA(3), SOS1(13), SOS2(17), TEC(8), VAV1(12), VAV2(7), VAV3(14), ZAP70(9)	36166709	922	211	743	213	224	317	201	11	152	17	0.000170	1.000	1.000
225	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(2), CAMK1G(5), HDAC9(16), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), YWHAH(3)	2977293	48	19	46	15	18	12	11	0	7	0	0.362	1.000	1.000
226	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(8), DUSP1(2), IKBKAP(13), IKBKB(13), IKBKG(4), MAP3K1(30), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), TNFAIP3(3), TRAF3(5), TRAF6(7)	6780716	110	40	109	25	25	42	20	1	20	2	0.107	1.000	1.000
227	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(4), AKT2(6), AKT3(11), BCL2L1(4), CBL(12), CBLB(12), CBLC(5), CCND1(15), CCND2(9), CCND3(4), CISH(2), CLCF1(1), CNTF(3), CNTFR(2), CREBBP(32), CRLF2(5), CSF2(1), CSF2RA(12), CSF2RB(14), CSF3(1), CSF3R(8), EP300(32), EPO(2), EPOR(4), GH1(3), GH2(3), GHR(8), GRB2(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(9), IFNGR1(5), IFNGR2(4), IFNK(2), IFNW1(3), IL10(3), IL10RA(4), IL10RB(6), IL11(2), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL13RA1(13), IL13RA2(7), IL15(2), IL19(2), IL2(2), IL20(9), IL20RA(3), IL21(3), IL21R(7), IL22RA1(4), IL22RA2(1), IL23A(4), IL23R(5), IL24(7), IL26(3), IL28A(3), IL28B(2), IL28RA(9), IL29(2), IL2RA(4), IL2RB(3), IL2RG(13), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL6ST(11), IL7(1), IL7R(12), IL9(1), IL9R(8), IRF9(4), JAK1(20), JAK2(17), JAK3(10), LEP(2), LEPR(12), LIF(3), LIFR(27), MPL(7), MYC(8), OSM(2), OSMR(13), PIAS1(7), PIAS2(15), PIAS3(9), PIAS4(5), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIM1(3), PRL(6), PRLR(5), PTPN11(8), PTPN6(6), SOCS2(6), SOCS4(5), SOCS5(12), SOCS7(5), SOS1(13), SOS2(17), SPRED1(3), SPRED2(8), SPRY1(3), SPRY2(5), SPRY3(6), SPRY4(2), STAM(7), STAM2(5), STAT1(15), STAT2(8), STAT3(10), STAT4(7), STAT5A(5), STAT5B(7), STAT6(10), TPO(15), TSLP(2), TYK2(10)	52598979	1251	220	1109	281	291	441	289	11	195	24	2.53e-07	1.000	1.000
228	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(17), HSD17B1(4), HSD17B2(2), HSD17B3(6), HSD17B4(13), HSD17B7(5), HSD3B1(3), HSD3B2(6)	2949521	59	30	56	21	12	29	6	0	12	0	0.645	1.000	1.000
229	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(21), CREM(8), FHL5(7), FSHR(17), GNAS(24), XPO1(18)	3289447	95	30	89	22	39	29	17	0	10	0	0.143	1.000	1.000
230	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(3), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), ST3GAL5(5), ST6GALNAC2(4), ST6GALNAC4(4), ST8SIA1(2)	1942787	29	21	28	10	13	11	4	0	1	0	0.398	1.000	1.000
231	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(3), TGDS(4), UGDH(2), UXS1(5)	1484004	15	12	15	9	4	6	4	0	1	0	0.960	1.000	1.000
232	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(13), IL13RA2(7), IL4R(6), JAK1(20), JAK2(17), TYK2(10)	3765029	73	32	73	23	15	24	19	1	11	3	0.524	1.000	1.000
233	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(13), IL13RA2(7), IL4R(6), JAK1(20), JAK2(17), TYK2(10)	3765029	73	32	73	23	15	24	19	1	11	3	0.524	1.000	1.000
234	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2)	2852783	50	24	49	18	17	18	8	2	5	0	0.416	1.000	1.000
235	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2)	2852783	50	24	49	18	17	18	8	2	5	0	0.416	1.000	1.000
236	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(21), COL4A2(12), COL4A3(26), COL4A4(24), COL4A5(26), COL4A6(32), P4HB(6), SLC23A1(8), SLC23A2(7), SLC2A1(2), SLC2A3(8)	9449324	172	49	167	50	42	85	22	3	17	3	0.111	1.000	1.000
237	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(9), PARK2(6), SNCA(3), SNCAIP(12), UBE2E2(3), UBE2F(3), UBE2G1(2), UBE2L3(2), UBE2L6(3)	2308876	43	21	43	14	10	19	9	0	4	1	0.477	1.000	1.000
238	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(5), ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(4), RAC1(1), WASF1(3), WASL(9)	3012972	43	22	43	13	16	17	2	0	8	0	0.403	1.000	1.000
239	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ACTB(3), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(14), CLDN1(3), CTNNB1(80), CTTN(4), EZR(4), FYN(7), HCLS1(12), ITGB1(8), KRT18(1), LY96(4), NCK1(4), NCK2(8), NCL(7), OCLN(2), PRKCA(10), RHOA(3), ROCK1(22), ROCK2(17), TLR4(17), TLR5(14), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(11), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4), WAS(11), WASL(9), YWHAQ(1), YWHAZ(1)	18662298	380	127	322	100	97	171	68	4	38	2	0.00626	1.000	1.000
240	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ACTB(3), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(4), CDH1(14), CLDN1(3), CTNNB1(80), CTTN(4), EZR(4), FYN(7), HCLS1(12), ITGB1(8), KRT18(1), LY96(4), NCK1(4), NCK2(8), NCL(7), OCLN(2), PRKCA(10), RHOA(3), ROCK1(22), ROCK2(17), TLR4(17), TLR5(14), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(11), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4), WAS(11), WASL(9), YWHAQ(1), YWHAZ(1)	18662298	380	127	322	100	97	171	68	4	38	2	0.00626	1.000	1.000
241	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), GOT1(9), GOT2(3), GPT(2), GPT2(5), MDH1(4), MDH2(4), ME1(12), ME2(8), ME3(9), PGK1(7), PKLR(7), PKM2(5), RPE(5), RPIA(9), TKT(6), TPI1(2)	6427743	117	46	114	30	38	46	19	2	12	0	0.0488	1.000	1.000
242	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(12), EIF2AK4(7), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF5(3), GSK3B(13), PPP1CA(3)	4163661	60	28	57	14	18	20	6	3	13	0	0.279	1.000	1.000
243	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(8), CREBBP(32), EP300(32), FADD(1), HDAC3(12), IKBKB(13), IKBKG(4), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TNFRSF1A(4), TNFRSF1B(2), TRAF6(7)	7984364	143	51	137	33	40	43	29	1	28	2	0.0387	1.000	1.000
244	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ESCO1(16), ESCO2(8), NAT6(1), PNPLA3(7), SH3GLB1(7)	6018126	55	26	55	12	16	25	7	0	7	0	0.133	1.000	1.000
245	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(7), BCAT2(3), IARS(8), IARS2(20), ILVBL(8), LARS(19), LARS2(8), PDHA1(7), PDHA2(10), PDHB(3), VARS(6), VARS2(1)	5974162	100	33	97	26	32	36	18	0	14	0	0.265	1.000	1.000
246	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(4), GRB2(3), IL2RG(13), IL4(1), IL4R(6), IRS1(13), JAK1(20), JAK3(10), RPS6KB1(5), SHC1(7), STAT6(10)	5172677	92	41	92	29	27	33	17	1	14	0	0.381	1.000	1.000
247	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(4), CD36(8), FOS(3), FYN(7), JUN(1), MAPK14(4), THBS1(11)	2646788	38	21	38	13	12	13	8	0	5	0	0.538	1.000	1.000
248	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(16), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLRMT(11)	4571137	88	40	87	25	33	28	13	0	13	1	0.275	1.000	1.000
249	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(6), ACAT2(4), ACOT11(5), ACYP1(2), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ECHS1(3), EHHADH(11), ESCO1(16), ESCO2(8), FN3K(5), GCDH(6), HADHA(6), NAT6(1), PNPLA3(7), SH3GLB1(7), YOD1(3)	9402046	106	42	106	29	25	48	21	0	12	0	0.253	1.000	1.000
250	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(8), ACADM(9), ACADS(4), ACADVL(9), ACSL1(14), ACSL3(7), ACSL4(21), CPT1A(9), CPT2(4), EHHADH(11), HADHA(6), PECR(6), SCP2(9), SLC25A20(4)	6111523	121	38	117	31	32	46	28	0	15	0	0.111	1.000	1.000
251	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(8), ACADM(9), ACADS(4), ACAT1(6), ECHS1(3), HADHA(6)	1930428	36	19	36	12	7	15	11	0	3	0	0.621	1.000	1.000
252	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(5), CHPT1(1), HEMK1(3), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(5), PCYT1A(4), PCYT1B(4), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), WBSCR22(5)	5002863	82	32	80	24	21	36	8	2	15	0	0.281	1.000	1.000
253	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CD14(2), CHUK(8), ELK1(3), FOS(3), IKBKB(13), IKBKG(4), IRAK1(4), JUN(1), LY96(4), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K14(6), MAP3K7(9), MAPK14(4), MAPK8(10), MYD88(3), NFKB1(10), NFKBIA(3), PPARA(1), RELA(6), TIRAP(2), TLR10(19), TLR2(16), TLR3(10), TLR4(17), TLR6(14), TLR7(17), TLR9(6), TOLLIP(1), TRAF6(7)	13189970	259	66	256	57	58	102	54	1	40	4	0.00399	1.000	1.000
254	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(54), CCNA1(5), CCNB1(8), CCND1(15), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNG2(2), CCNH(7), CDC25A(8), CDK2(2), CDK4(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(2), CDKN2C(4), CDKN2D(1), CREB3L1(3), CREB3L3(7), CREB3L4(6), E2F1(9), E2F2(3), E2F3(4), E2F4(3), E2F5(6), E2F6(1), GBA2(13), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(4), MYC(8), MYT1(18), NACA(21), PCNA(3), POLA2(3), POLE(47), POLE2(4), PRIM1(3), RB1(26), RBL1(14), RPA1(6), RPA2(3), RPA3(3), TFDP1(13), TFDP2(6), TNXB(19), TP53(74), WEE1(2)	27079694	532	147	483	126	150	189	103	3	81	6	0.00127	1.000	1.000
255	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), DCXR(1), GUSB(5), RPE(5), UGDH(2), UGP2(6), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), XYLB(5)	9582049	176	40	167	33	36	84	32	1	23	0	0.00301	1.000	1.000
256	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(5), ACAD9(8), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ESCO1(16), ESCO2(8), NAT6(1), PNPLA3(7), SH3GLB1(7)	9147786	108	34	108	24	33	41	17	0	16	1	0.0386	1.000	1.000
257	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(21), COL4A2(12), COL4A3(26), COL4A4(24), COL4A5(26), COL4A6(32), F10(14), F11(15), F12(2), F2(8), F2R(6), F5(48), F8(45), F9(14), FGA(26), FGB(7), FGG(10), KLKB1(10), PROC(5), PROS1(21), SERPINC1(10), SERPING1(7)	16412302	389	69	371	94	87	184	67	3	44	4	0.00948	1.000	1.000
258	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(5), ANXA2(4), ANXA3(3), ANXA4(9), ANXA5(3), ANXA6(11), CYP11A1(9), EDN1(4), EDNRA(5), EDNRB(4), HPGD(6), HSD11B1(6), PLA2G4A(13), PRL(6), PTGDR(9), PTGDS(5), PTGER2(3), PTGER4(12), PTGFR(13), PTGIR(3), PTGIS(7), PTGS1(6), PTGS2(9), SCGB1A1(2), TBXAS1(7)	7412477	164	50	163	40	47	67	30	2	18	0	0.0192	1.000	1.000
259	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ADCY3(12), ADCY9(27), AK1(1), ARF1(3), ARF3(4), ARF4(3), ARF5(4), ARF6(3), ARL4D(1), ATP6V0A1(7), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), ERO1L(6), GNAS(24), PDIA4(5), PLCG1(12), PLCG2(29), PRKCA(10), SEC61A1(5), SEC61A2(4), SEC61B(2), SEC61G(3), TRIM23(11)	13444408	274	65	266	66	94	90	48	3	37	2	0.00293	1.000	1.000
260	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(22), C5(18), C6(16), C7(20), ICAM1(2), IL6(5), IL8(3), ITGA4(10), ITGAL(17), ITGB1(8), ITGB2(14), SELP(12), SELPLG(9), VCAM1(12)	9034468	168	51	161	46	43	72	25	1	25	2	0.0577	1.000	1.000
261	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(3), EHHADH(11), HADH(1), HADHA(6), HSD17B10(4), HSD17B4(13), NTAN1(3), SIRT1(6), SIRT2(8), SIRT5(5), SIRT7(6), VNN2(11)	4305314	78	29	76	24	20	32	19	0	7	0	0.499	1.000	1.000
262	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(6), CSF1R(8), DDX20(4), E2F1(9), E2F4(3), ETS1(6), ETS2(6), ETV3(11), FOS(3), HDAC2(5), HDAC5(12), HRAS(1), JUN(1), NCOR2(23), RBL1(14), RBL2(19), SIN3A(29), SIN3B(13)	9425937	173	61	166	44	59	49	34	0	30	1	0.0358	1.000	1.000
263	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(12), EGF(20), EGFR(12), GRB2(3), HRAS(1), MAP2K1(2), MAPK1(2), MAPK3(3), PTPRB(31), RAF1(8), RASA1(30), SHC1(7), SOS1(13), SPRY1(3), SPRY2(5), SPRY3(6), SPRY4(2), SRC(3)	9178228	163	61	156	37	41	59	38	0	24	1	0.0433	1.000	1.000
264	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), GOT1(9), GOT2(3), GPT(2), GPT2(5), MDH1(4), MDH2(4), ME1(12), ME3(9), PGK1(7), PGK2(6), PKLR(7), PKM2(5), RPE(5), RPIA(9), TKT(6), TKTL1(9), TKTL2(16), TPI1(2)	7208802	140	53	135	37	48	56	18	2	16	0	0.0340	1.000	1.000
265	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(8), ALOX15(9), ALOX15B(6), ALOX5(10), ALOX5AP(3), DPEP1(3), GGT1(5), LTA4H(4), PLA2G6(9), PTGDS(5), PTGES(2), PTGIS(7), PTGS1(6), PTGS2(9), TBXAS1(7)	5401004	93	33	91	27	40	29	17	1	6	0	0.130	1.000	1.000
266	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(17), BAD(2), BAK1(3), BAX(3), BCL2L1(4), BCL2L11(6), BID(2), BIRC2(10), BIRC3(5), BIRC5(4), BNIP3L(1), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CHUK(8), CYCS(2), DFFB(4), FADD(1), FAS(9), FASLG(7), GZMB(4), HELLS(11), IKBKB(13), IKBKG(4), IRF1(1), IRF2(7), IRF3(2), IRF4(8), IRF5(8), IRF6(9), IRF7(1), JUN(1), LTA(3), MAP2K4(9), MAP3K1(30), MAPK10(9), MDM2(4), MYC(8), NFKB1(10), NFKBIA(3), NFKBIB(1), NFKBIE(6), PLEKHG5(6), PRF1(8), RELA(6), RIPK1(9), TNFRSF10B(5), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(3), TNFSF10(1), TP53(74), TP73(6), TRAF1(5), TRAF2(3), TRAF3(5)	20246836	448	130	415	108	112	167	77	3	86	3	0.00434	1.000	1.000
267	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(18), CAPN1(5), CAPNS1(2), CAPNS2(3), CDK5(2), CDK5R1(3), CSNK1A1(4), CSNK1D(3), GSK3B(13), MAPT(9), PPP2CA(6)	3361556	68	29	67	22	31	18	9	0	10	0	0.322	1.000	1.000
268	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(3), CALR(3), CANX(5), CD4(6), CD74(1), CD8A(2), CD8B(1), CIITA(15), CREB1(6), CTSL1(5), CTSS(4), HLA-A(1), HLA-B(4), HLA-C(2), HLA-DMA(3), HLA-DOA(3), HLA-DOB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB5(2), HLA-E(1), HLA-F(3), HLA-G(2), HSP90AA1(7), HSP90AB1(21), HSPA5(6), IFI30(1), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), KIR2DL1(5), KIR2DL3(1), KIR2DL4(4), KIR2DS4(5), KIR3DL1(10), KIR3DL2(5), KIR3DL3(3), KLRC1(7), KLRC2(3), KLRC3(1), KLRC4(5), KLRD1(3), LGMN(7), LTA(3), NFYA(9), NFYB(2), NFYC(3), PDIA3(5), PSME1(1), PSME2(4), RFX5(9), RFXANK(4), RFXAP(2), TAP1(8), TAP2(1), TAPBP(4)	15021381	264	64	255	66	67	123	42	0	31	1	0.0106	1.000	1.000
269	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(8), MAP3K14(6), MAPK14(4), MAPK8(10), NFKB1(10), RELA(6), TNFRSF13B(3), TNFRSF17(1), TNFSF13B(5), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(7)	5225351	75	37	74	21	20	25	15	1	14	0	0.315	1.000	1.000
270	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(54), MAP2(31), PPP1CA(3), PPP2CA(6), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAR2A(4), PRKAR2B(3), PRKCE(10)	6652974	126	40	123	31	24	50	29	0	20	3	0.231	1.000	1.000
271	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(10), CPEB1(9), EGFR(12), ERBB2(10), ERBB4(27), ETS1(6), ETS2(6), ETV6(6), ETV7(4), FMN2(28), GRB2(3), KRAS(53), MAP2K1(2), MAPK1(2), MAPK3(3), NOTCH1(11), NOTCH2(18), NOTCH3(29), NOTCH4(12), PIWIL1(21), PIWIL2(14), PIWIL3(10), PIWIL4(14), RAF1(8), SOS1(13), SOS2(17), SPIRE1(9), SPIRE2(4)	17642222	361	113	305	85	89	166	63	6	36	1	0.00345	1.000	1.000
272	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(4), EGFR(12), IGF1R(13), MYC(8), POLR2A(21), PPP2CA(6), PRKCA(10), RB1(26), TEP1(13), TERF1(1), TERT(4), TNKS(15), TP53(74), XRCC5(8)	10199390	215	105	188	58	80	53	39	3	37	3	0.0393	1.000	1.000
273	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(17), ACO2(7), CS(6), GRHPR(3), HAO1(3), HAO2(11), HYI(2), MDH1(4), MDH2(4), MTHFD1(6), MTHFD1L(15), MTHFD2(4)	4710422	82	35	80	26	37	22	18	0	5	0	0.256	1.000	1.000
274	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(5), TAX1BP3(1), UBE2A(3), UBE2B(3), UBE2C(1), UBE2D2(4), UBE2D3(2), UBE2E1(3), UBE2E3(7), UBE2G1(2), UBE2H(1), UBE2J1(1), UBE2L3(2), UBE2L6(3), UBE2N(4), UBE3A(16)	3762990	58	27	58	20	16	15	16	2	9	0	0.630	1.000	1.000
275	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB10(4), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(2), PSMB8(2), PSMB9(1)	3015723	44	23	42	14	12	12	8	0	12	0	0.536	1.000	1.000
276	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), AKT1(4), AKT2(6), AKT3(11), ARHGAP5(21), BAD(2), BCAR1(8), BIRC2(10), BIRC3(5), BRAF(10), CAPN2(11), CAV1(2), CAV2(1), CCND1(15), CCND2(9), CCND3(4), CDC42(4), CHAD(3), COL11A1(37), COL11A2(10), COL1A1(12), COL1A2(24), COL2A1(15), COL3A1(19), COL4A1(21), COL4A2(12), COL4A4(24), COL4A6(32), COL5A1(29), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(14), COL6A3(45), COL6A6(27), COMP(6), CRK(2), CRKL(6), CTNNB1(80), DIAPH1(13), DOCK1(24), EGF(20), EGFR(12), ELK1(3), ERBB2(10), FARP2(15), FIGF(5), FLNA(40), FLNB(34), FLNC(37), FLT1(20), FN1(43), FYN(7), GRB2(3), GSK3B(13), HGF(14), HRAS(1), IBSP(7), IGF1(5), IGF1R(13), ILK(5), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAV(10), ITGB1(8), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), JUN(1), KDR(26), LAMA1(32), LAMA2(61), LAMA3(30), LAMA4(15), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(16), LAMB4(32), LAMC1(18), LAMC2(17), LAMC3(17), MAP2K1(2), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK9(5), MET(17), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLK(14), MYLK2(8), MYLPF(2), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PARVA(4), PARVB(2), PARVG(8), PDGFA(3), PDGFB(2), PDGFC(3), PDGFD(8), PDGFRA(24), PDGFRB(12), PDPK1(3), PGF(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP5K1C(5), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R12A(8), PRKCA(10), PRKCG(8), PTEN(228), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAF1(8), RAP1A(4), RAP1B(2), RAPGEF1(11), RELN(48), RHOA(3), ROCK1(22), ROCK2(17), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SPP1(2), SRC(3), THBS1(11), THBS2(20), THBS3(3), THBS4(12), TLN1(23), TLN2(29), TNC(26), TNN(19), TNR(15), TNXB(19), VASP(3), VAV1(12), VAV2(7), VAV3(14), VCL(11), VEGFA(2), VEGFB(2), VEGFC(6), VTN(3), VWF(25), ZYX(11)	132352116	2820	237	2495	766	741	1007	502	60	446	64	2.47e-07	1.000	1.000
277	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(4), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), APC(56), ARAF(12), ARHGEF1(12), ARHGEF12(29), ARHGEF4(9), ARHGEF6(26), ARHGEF7(15), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(5), BCAR1(8), BDKRB1(3), BDKRB2(8), BRAF(10), CD14(2), CDC42(4), CFL1(1), CFL2(8), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CRK(2), CRKL(6), CSK(1), CYFIP1(9), CYFIP2(20), DIAPH1(13), DIAPH2(31), DIAPH3(27), DOCK1(24), EGF(20), EGFR(12), EZR(4), F2(8), F2R(6), FGD1(15), FGD3(9), FGF10(2), FGF11(1), FGF12(5), FGF13(4), FGF14(4), FGF17(1), FGF18(1), FGF21(1), FGF23(3), FGF3(1), FGF5(9), FGF6(2), FGF7(5), FGF8(4), FGF9(1), FGFR1(10), FGFR2(34), FGFR3(6), FGFR4(16), FN1(43), GIT1(9), GNA12(8), GNA13(7), GNG12(1), GSN(5), HRAS(1), INS(3), IQGAP1(12), IQGAP2(24), IQGAP3(16), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAD(10), ITGAE(9), ITGAL(17), ITGAM(21), ITGAV(10), ITGAX(14), ITGB1(8), ITGB2(14), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), KRAS(53), LIMK1(8), LIMK2(15), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MOS(6), MRAS(1), MSN(18), MYH10(29), MYH14(23), MYH9(22), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLK(14), MYLK2(8), MYLPF(2), NCKAP1(8), NCKAP1L(20), NRAS(9), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PDGFA(3), PDGFB(2), PDGFRA(24), PDGFRB(12), PFN1(1), PFN2(2), PFN4(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(5), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R12A(8), PPP1R12B(20), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAF1(8), RDX(16), RHOA(3), ROCK1(22), ROCK2(17), RRAS(3), RRAS2(4), SCIN(6), SLC9A1(8), SOS1(13), SOS2(17), SSH1(17), SSH2(13), SSH3(4), TIAM1(27), TIAM2(14), VAV1(12), VAV2(7), VAV3(14), VCL(11), WAS(11), WASF1(3), WASF2(3), WASL(9)	100375796	2109	225	1876	599	578	763	403	27	307	31	0.000331	1.000	1.000
278	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), ARHGAP5(21), BCAR1(8), CD99(1), CDC42(4), CDH5(6), CLDN1(3), CLDN10(8), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CTNNA1(18), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTNND1(27), CXCL12(6), CXCR4(1), CYBA(2), CYBB(9), ESAM(1), EZR(4), F11R(1), GNAI1(5), GNAI2(6), GNAI3(4), ICAM1(2), ITGA4(10), ITGAL(17), ITGAM(21), ITGB1(8), ITGB2(14), ITK(7), JAM2(9), JAM3(3), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MLLT4(21), MMP2(7), MMP9(12), MSN(18), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), NCF1(3), NCF2(8), NCF4(5), NOX1(16), NOX3(7), OCLN(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(29), PRKCA(10), PRKCG(8), PTK2(12), PTK2B(16), PTPN11(8), PXN(6), RAC1(1), RAC2(3), RAP1A(4), RAP1B(2), RAPGEF3(10), RAPGEF4(15), RASSF5(3), RHOA(3), RHOH(1), ROCK1(22), ROCK2(17), SIPA1(1), THY1(1), TXK(6), VASP(3), VAV1(12), VAV2(7), VAV3(14), VCAM1(12), VCL(11)	44542115	1140	221	950	291	284	409	236	12	179	20	0.000446	1.000	1.000
279	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(33), ACACB(29), AKT1(4), AKT2(6), AKT3(11), ARAF(12), BAD(2), BRAF(10), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CBL(12), CBLB(12), CBLC(5), CRK(2), CRKL(6), ELK1(3), EXOC7(4), FASN(7), FBP1(2), FBP2(1), FLOT1(1), FLOT2(2), FOXO1(12), G6PC(5), G6PC2(11), GCK(3), GRB2(3), GSK3B(13), GYS1(13), GYS2(16), HRAS(1), IKBKB(13), INPP5D(9), INS(3), INSR(18), IRS1(13), IRS4(21), KRAS(53), LIPE(13), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK10(9), MAPK3(3), MAPK8(10), MAPK9(5), MKNK1(3), MKNK2(3), NRAS(9), PCK1(9), PCK2(7), PDE3A(19), PDE3B(15), PDPK1(3), PFKL(8), PFKM(9), PFKP(8), PHKA1(20), PHKA2(21), PHKB(15), PHKG1(7), PHKG2(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(100), PIK3R2(7), PIK3R3(9), PIK3R5(10), PKLR(7), PKM2(5), PPARGC1A(9), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R3A(32), PPP1R3B(2), PPP1R3C(4), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKACA(6), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAG2(4), PRKAG3(6), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCI(6), PRKCZ(3), PRKX(2), PTPN1(5), PTPRF(27), PYGB(11), PYGL(8), PYGM(10), RAF1(8), RAPGEF1(11), RHEB(3), RHOQ(1), RPS6(7), RPS6KB1(5), RPS6KB2(4), SH2B2(1), SHC1(7), SHC2(5), SHC3(15), SHC4(5), SLC2A4(9), SOCS2(6), SOCS4(5), SORBS1(18), SOS1(13), SOS2(17), SREBF1(2), TRIP10(10), TSC1(13), TSC2(15)	56199251	1340	221	1146	337	388	449	263	15	204	21	2.08e-06	1.000	1.000
280	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(56), AXIN1(9), AXIN2(9), BTRC(14), CACYBP(2), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CCND1(15), CCND2(9), CCND3(4), CER1(4), CHD8(34), CREBBP(32), CSNK1A1(4), CSNK1A1L(4), CSNK1E(3), CSNK2A1(9), CSNK2A2(4), CTBP1(1), CTBP2(5), CTNNB1(80), CUL1(13), CXXC4(1), DAAM1(18), DAAM2(10), DKK1(3), DKK2(3), DKK4(3), DVL1(3), DVL2(10), DVL3(9), EP300(32), FBXW11(5), FOSL1(3), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD4(4), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GSK3B(13), JUN(1), LEF1(9), LRP5(14), LRP6(26), MAP3K7(9), MAPK10(9), MAPK8(10), MAPK9(5), MYC(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NKD1(3), NLK(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PORCN(12), PPARD(3), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRICKLE1(6), PRICKLE2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), PSEN1(5), RAC1(1), RAC2(3), RBX1(1), RHOA(3), ROCK1(22), ROCK2(17), RUVBL1(3), SENP2(12), SFRP1(6), SFRP2(4), SFRP4(9), SFRP5(2), SIAH1(6), SMAD2(9), SMAD3(7), SMAD4(5), SOX17(7), TBL1X(8), TBL1XR1(15), TCF7(3), TCF7L1(4), TCF7L2(11), TP53(74), VANGL1(6), VANGL2(10), WIF1(5), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(8), WNT3(3), WNT3A(1), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2)	56493350	1178	218	1056	318	385	413	219	10	143	8	4.83e-05	1.000	1.000
281	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), AKT1(4), AKT2(6), AKT3(11), AMOTL1(13), ASH1L(42), CASK(18), CDC42(4), CDK4(3), CGN(14), CLDN1(3), CLDN10(8), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CRB3(1), CSDA(4), CSNK2A1(9), CSNK2A2(4), CTNNA1(18), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTTN(4), EPB41(11), EPB41L1(15), EPB41L2(14), EPB41L3(17), EXOC3(8), EXOC4(6), F11R(1), GNAI1(5), GNAI2(6), GNAI3(4), HCLS1(12), HRAS(1), IGSF5(6), INADL(20), JAM2(9), JAM3(3), KRAS(53), LLGL1(10), LLGL2(7), MAGI1(24), MAGI2(28), MAGI3(16), MLLT4(21), MPDZ(22), MPP5(10), MRAS(1), MYH1(45), MYH10(29), MYH11(33), MYH13(22), MYH14(23), MYH15(23), MYH2(43), MYH3(30), MYH4(31), MYH6(16), MYH7(35), MYH7B(16), MYH8(30), MYH9(22), MYL2(2), MYL5(1), MYL7(3), MYL9(3), MYLPF(2), NRAS(9), OCLN(2), PARD3(19), PARD6B(3), PARD6G(1), PPM1J(3), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PPP2R3A(12), PPP2R3B(9), PPP2R4(5), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(3), PTEN(228), RAB13(3), RAB3B(2), RHOA(3), RRAS(3), RRAS2(4), SPTAN1(31), SRC(3), SYMPK(17), TJAP1(6), TJP1(24), TJP2(16), TJP3(7), VAPA(6), YES1(8), ZAK(15)	70594305	1675	216	1432	457	445	589	282	52	268	39	0.00103	1.000	1.000
282	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1B(9), ACVR1C(6), AKT1(4), AKT2(6), AKT3(11), ARRB1(4), ARRB2(4), ATF2(8), ATF4(3), BDNF(7), BRAF(10), CACNA1A(20), CACNA1B(35), CACNA1C(38), CACNA1D(29), CACNA1E(60), CACNA1F(41), CACNA1G(24), CACNA1H(12), CACNA1I(8), CACNA1S(33), CACNA2D1(14), CACNA2D2(10), CACNA2D3(22), CACNA2D4(15), CACNB1(12), CACNB2(13), CACNB3(5), CACNB4(13), CACNG1(1), CACNG2(3), CACNG3(10), CACNG4(6), CACNG5(4), CACNG6(4), CACNG7(7), CACNG8(1), CASP3(4), CD14(2), CDC25B(3), CDC42(4), CHUK(8), CRK(2), CRKL(6), DAXX(10), DDIT3(2), DUSP1(2), DUSP10(5), DUSP14(4), DUSP16(11), DUSP3(2), DUSP5(4), DUSP6(2), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(5), EGF(20), EGFR(12), ELK1(3), ELK4(3), FAS(9), FASLG(7), FGF10(2), FGF11(1), FGF12(5), FGF13(4), FGF14(4), FGF17(1), FGF18(1), FGF21(1), FGF23(3), FGF3(1), FGF5(9), FGF6(2), FGF7(5), FGF8(4), FGF9(1), FGFR1(10), FGFR2(34), FGFR3(6), FGFR4(16), FLNA(40), FLNB(34), FLNC(37), FOS(3), GADD45G(1), GNA12(8), GNG12(1), GRB2(3), HRAS(1), IKBKB(13), IKBKG(4), IL1B(2), IL1R1(5), IL1R2(5), JUN(1), KRAS(53), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K5(3), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K12(8), MAP3K13(13), MAP3K14(6), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAP3K5(25), MAP3K6(7), MAP3K7(9), MAP3K8(10), MAP4K1(11), MAP4K2(7), MAP4K3(16), MAP4K4(11), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK7(14), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5), MAPKAPK2(6), MAPKAPK3(5), MAPKAPK5(5), MAPT(9), MAX(12), MEF2C(11), MKNK1(3), MKNK2(3), MOS(6), MRAS(1), MYC(8), NF1(36), NFATC2(13), NFATC4(7), NFKB1(10), NFKB2(9), NLK(5), NR4A1(5), NRAS(9), NTF3(5), NTRK1(13), NTRK2(13), PAK1(3), PAK2(3), PDGFA(3), PDGFB(2), PDGFRA(24), PDGFRB(12), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PPM1A(6), PPM1B(4), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PPP5C(7), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), PTPN5(8), PTPN7(6), PTPRR(17), RAC1(1), RAC2(3), RAF1(8), RAP1A(4), RAP1B(2), RAPGEF2(30), RASA1(30), RASA2(11), RASGRF1(11), RASGRF2(18), RASGRP1(8), RASGRP2(4), RASGRP3(13), RASGRP4(6), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA4(2), RPS6KA5(11), RPS6KA6(19), RRAS(3), RRAS2(4), SOS1(13), SOS2(17), SRF(3), STK3(12), STK4(9), STMN1(4), TAOK1(12), TAOK2(9), TAOK3(5), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TNFRSF1A(4), TP53(74), TRAF2(3), TRAF6(7), ZAK(15)	104048776	2109	201	1973	646	662	765	373	29	265	15	0.000376	1.000	1.000
283	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(11), ACVR1B(9), ACVRL1(2), AKT1(4), AURKB(4), BMPR1A(5), BMPR2(12), BUB1(10), CDKL1(9), CDKL2(5), CDS1(5), CLK1(7), CLK2(9), CLK4(6), COL4A3BP(3), CSNK2A1(9), CSNK2A2(4), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKQ(2), DGKZ(10), IMPA1(4), INPP1(3), INPP4A(21), INPP4B(16), INPP5A(5), INPPL1(19), ITPKA(1), ITPKB(12), MAP3K10(7), MOS(6), NEK1(19), NEK3(7), OCRL(19), PIK3C2A(23), PIK3C2B(10), PIK3C2G(16), PIK3CA(172), PIK3CB(17), PIK3CG(23), PIM2(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCG1(12), PLCG2(29), PLK3(8), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), PRKCZ(3), PRKD1(8), PRKG1(11), RAF1(8), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA4(2), RPS6KB1(5), STK11(2), TGFBR1(5), VRK1(12)	41274078	880	184	761	257	257	293	212	10	106	2	0.0849	1.000	1.000
284	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CREB1(6), CREB3L1(3), CREB3L2(7), CREB3L3(7), CREB3L4(6), CREBBP(32), CTNNB1(80), DCT(13), DVL1(3), DVL2(10), DVL3(9), EDN1(4), EDNRB(4), EP300(32), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD4(4), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GNAI1(5), GNAI2(6), GNAI3(4), GNAO1(7), GNAQ(3), GNAS(24), GSK3B(13), HRAS(1), KIT(24), KITLG(3), KRAS(53), LEF1(9), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MC1R(3), MITF(6), NRAS(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), POMC(4), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), RAF1(8), TCF7(3), TCF7L1(4), TCF7L2(11), TYR(12), TYRP1(7), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(8), WNT3(3), WNT3A(1), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2)	37866316	837	177	717	267	276	306	159	11	83	2	0.0146	1.000	1.000
285	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(8), ANAPC1(21), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(8), ANAPC7(5), ATM(54), ATR(43), BUB1(10), BUB1B(6), BUB3(4), CCNA1(5), CCNA2(7), CCNB1(8), CCNB2(5), CCNB3(33), CCND1(15), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNH(7), CDC14A(6), CDC14B(6), CDC16(12), CDC20(4), CDC23(7), CDC25A(8), CDC25B(3), CDC25C(5), CDC6(3), CDC7(11), CDK2(2), CDK4(3), CDK6(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(2), CDKN2C(4), CDKN2D(1), CHEK1(2), CHEK2(14), CREBBP(32), CUL1(13), DBF4(11), E2F1(9), E2F2(3), E2F3(4), EP300(32), ESPL1(11), FZR1(2), GADD45G(1), GSK3B(13), HDAC1(5), HDAC2(5), MAD1L1(12), MAD2L1(4), MAD2L2(2), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(4), PCNA(3), PKMYT1(2), PLK1(4), PRKDC(54), PTTG1(2), PTTG2(1), RB1(26), RBL1(14), RBL2(19), RBX1(1), SKP2(7), SMAD2(9), SMAD3(7), SMAD4(5), SMC1A(19), SMC1B(21), TFDP1(13), TGFB1(2), TGFB2(5), TGFB3(9), TP53(74), WEE1(2), YWHAE(4), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	49263559	911	175	861	225	256	296	183	5	159	12	0.00423	1.000	1.000
286	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY7(9), ADCY8(22), ADCY9(27), ADORA2A(6), ADORA2B(1), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRB2(7), ADRB3(3), AGTR1(4), ATP2A1(12), ATP2A2(8), ATP2A3(11), ATP2B1(15), ATP2B2(12), ATP2B3(17), ATP2B4(14), AVPR1A(7), AVPR1B(3), BDKRB1(3), BDKRB2(8), BST1(1), CACNA1A(20), CACNA1B(35), CACNA1C(38), CACNA1D(29), CACNA1E(60), CACNA1F(41), CACNA1G(24), CACNA1H(12), CACNA1I(8), CACNA1S(33), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CCKAR(9), CCKBR(3), CD38(6), CHRM1(6), CHRM2(10), CHRM3(8), CHRM5(9), CHRNA7(5), CYSLTR1(8), CYSLTR2(5), DRD1(7), EDNRA(5), EDNRB(4), EGFR(12), ERBB2(10), ERBB3(20), ERBB4(27), F2R(6), GNA11(2), GNA14(7), GNA15(2), GNAL(6), GNAQ(3), GNAS(24), GRIN1(4), GRIN2A(25), GRIN2C(6), GRIN2D(5), GRM1(29), GRM5(27), GRPR(4), HRH1(10), HRH2(4), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), LHCGR(17), LTB4R2(4), MYLK(14), MYLK2(8), NOS1(18), NOS3(11), NTSR1(5), OXTR(4), P2RX1(5), P2RX2(3), P2RX3(8), P2RX4(1), P2RX5(5), P2RX7(1), PDE1A(15), PDE1B(7), PDE1C(12), PDGFRA(24), PDGFRB(12), PHKA1(20), PHKA2(21), PHKB(15), PHKG1(7), PHKG2(3), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(5), PLCD3(3), PLCD4(11), PLCE1(41), PLCG1(12), PLCG2(29), PLCZ1(14), PLN(2), PPID(3), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), PTAFR(4), PTGER3(7), PTGFR(13), PTK2B(16), RYR1(72), RYR2(111), RYR3(94), SLC25A4(2), SLC25A5(2), SLC25A6(5), SLC8A1(13), SLC8A2(6), SLC8A3(13), SPHK1(2), SPHK2(2), TACR1(7), TACR2(3), TACR3(9), TNNC1(2), TNNC2(3), TRHR(3), TRPC1(13), VDAC1(2), VDAC2(3), VDAC3(2)	98590383	1964	172	1913	760	679	717	347	15	196	10	0.638	1.000	1.000
287	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADCYAP1R1(5), ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(5), ADRA1A(12), ADRA1B(6), ADRA2A(6), ADRA2B(7), ADRA2C(2), ADRB2(7), ADRB3(3), AGTR1(4), AGTR2(11), AVPR1A(7), AVPR1B(3), AVPR2(5), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), C5AR1(3), CALCR(9), CALCRL(8), CCKAR(9), CCKBR(3), CGA(1), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CNR1(12), CNR2(6), CRHR1(3), CRHR2(2), CTSG(3), CYSLTR1(8), CYSLTR2(5), DRD1(7), DRD2(8), DRD3(6), DRD5(11), EDNRA(5), EDNRB(4), F2(8), F2R(6), F2RL1(4), F2RL2(2), FPR1(2), FSHR(17), GABBR1(12), GABBR2(15), GABRA1(14), GABRA2(14), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(7), GABRB1(9), GABRB2(15), GABRB3(10), GABRD(6), GABRE(7), GABRG1(10), GABRG2(16), GABRG3(9), GABRP(5), GABRQ(11), GABRR1(3), GALR1(3), GALR3(2), GH1(3), GH2(3), GHR(8), GHRHR(2), GHSR(8), GIPR(5), GLP1R(5), GLP2R(11), GLRA1(8), GLRA2(8), GLRA3(9), GLRB(7), GNRHR(4), GPR156(7), GPR35(3), GPR50(8), GPR63(5), GPR83(3), GRIA1(13), GRIA2(20), GRIA3(22), GRIA4(19), GRID1(13), GRID2(16), GRIK1(17), GRIK2(12), GRIK3(16), GRIK4(7), GRIK5(18), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), GRIN3A(15), GRIN3B(3), GRM1(29), GRM2(9), GRM3(19), GRM4(12), GRM5(27), GRM6(15), GRM7(20), GRM8(19), GRPR(4), GZMA(6), HCRTR2(11), HRH1(10), HRH2(4), HRH3(2), HRH4(5), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5), LEP(2), LEPR(12), LHB(2), LHCGR(17), LTB4R(2), LTB4R2(4), MAS1(3), MC1R(3), MC2R(4), MC3R(5), MC4R(5), MC5R(14), MCHR1(8), MCHR2(3), MLNR(5), MTNR1A(5), MTNR1B(4), NMBR(4), NMUR1(4), NMUR2(8), NPBWR2(1), NPFFR1(3), NPFFR2(13), NPY1R(9), NPY2R(5), NPY5R(13), NR3C1(18), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(13), OXTR(4), P2RX1(5), P2RX2(3), P2RX3(8), P2RX4(1), P2RX5(5), P2RX7(1), P2RY1(3), P2RY10(8), P2RY11(7), P2RY13(2), P2RY14(6), P2RY2(3), P2RY4(5), P2RY6(4), P2RY8(7), PARD3(19), PPYR1(8), PRL(6), PRLHR(1), PRLR(5), PRSS1(4), PRSS3(2), PTAFR(4), PTGDR(9), PTGER2(3), PTGER3(7), PTGER4(12), PTGFR(13), PTGIR(3), PTH2R(12), RXFP1(22), RXFP2(14), SCTR(5), SSTR1(10), SSTR2(3), SSTR3(3), SSTR4(10), SSTR5(2), TAAR1(7), TAAR2(7), TAAR5(5), TAAR6(6), TAAR8(3), TAAR9(8), TACR1(7), TACR2(3), TACR3(9), THRA(6), THRB(4), TRHR(3), TRPV1(3), TSHB(3), TSHR(8), TSPO(2), VIPR1(3), VIPR2(4)	77867473	1746	163	1689	652	540	754	284	19	144	5	0.102	1.000	1.000
288	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(8), ABLIM1(7), ABLIM2(8), ABLIM3(8), ARHGEF12(29), CDC42(4), CDK5(2), CFL1(1), CFL2(8), CXCL12(6), CXCR4(1), DCC(34), DPYSL2(12), DPYSL5(4), EFNA1(1), EFNA3(1), EFNA4(3), EFNA5(3), EFNB1(6), EFNB2(2), EFNB3(1), EPHA1(11), EPHA2(5), EPHA3(18), EPHA4(19), EPHA5(25), EPHA6(21), EPHA7(9), EPHA8(13), EPHB1(26), EPHB2(12), EPHB3(6), EPHB4(4), EPHB6(11), FES(17), FYN(7), GNAI1(5), GNAI2(6), GNAI3(4), GSK3B(13), HRAS(1), ITGB1(8), KRAS(53), L1CAM(20), LIMK1(8), LIMK2(15), LRRC4C(13), MAPK1(2), MAPK3(3), MET(17), NCK1(4), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NGEF(16), NRAS(9), NRP1(16), NTN1(3), NTN4(6), NTNG1(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PLXNA1(24), PLXNA2(25), PLXNA3(18), PLXNB1(14), PLXNB2(16), PLXNB3(23), PLXNC1(26), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PTK2(12), RAC1(1), RAC2(3), RASA1(30), RGS3(11), RHOA(3), RHOD(1), RND1(6), ROBO1(24), ROBO2(24), ROBO3(16), ROCK1(22), ROCK2(17), SEMA3A(8), SEMA3B(6), SEMA3C(13), SEMA3D(14), SEMA3E(9), SEMA3F(6), SEMA3G(5), SEMA4A(8), SEMA4B(4), SEMA4C(7), SEMA4D(6), SEMA4F(11), SEMA4G(4), SEMA5A(19), SEMA5B(8), SEMA6A(9), SEMA6B(3), SEMA6C(5), SEMA6D(26), SEMA7A(11), SLIT1(14), SLIT2(29), SLIT3(20), SRGAP1(17), SRGAP2(14), SRGAP3(11), UNC5A(9), UNC5B(8), UNC5C(10), UNC5D(15)	69179806	1349	163	1265	453	432	490	238	8	175	6	0.144	1.000	1.000
289	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(5), ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN3(10), ACTN4(8), ACVR1B(9), ACVR1C(6), BAIAP2(5), CDC42(4), CDH1(14), CREBBP(32), CSNK2A1(9), CSNK2A2(4), CTNNA1(18), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTNND1(27), EGFR(12), EP300(32), ERBB2(10), FARP2(15), FER(14), FGFR1(10), FYN(7), IGF1R(13), INSR(18), IQGAP1(12), LEF1(9), LMO7(26), MAP3K7(9), MAPK1(2), MAPK3(3), MET(17), MLLT4(21), NLK(5), PARD3(19), PTPN1(5), PTPN6(6), PTPRB(31), PTPRF(27), PTPRJ(18), PTPRM(15), PVRL1(10), PVRL2(5), PVRL3(7), PVRL4(4), RAC1(1), RAC2(3), RHOA(3), SMAD2(9), SMAD3(7), SMAD4(5), SNAI1(2), SNAI2(5), SORBS1(18), SRC(3), SSX2IP(11), TCF7(3), TCF7L1(4), TCF7L2(11), TGFBR1(5), TGFBR2(6), TJP1(24), VCL(11), WAS(11), WASF1(3), WASF2(3), WASF3(8), WASL(9), YES1(8)	43898605	849	162	772	222	254	303	169	10	106	7	0.000342	1.000	1.000
290	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(8), ATM(54), BUB1(10), BUB1B(6), BUB3(4), CCNA1(5), CCNA2(7), CCNB1(8), CCNB2(5), CCNB3(33), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNH(7), CDAN1(9), CDC14A(6), CDC14B(6), CDC20(4), CDC25A(8), CDC25B(3), CDC25C(5), CDC6(3), CDC7(11), CDH1(14), CDK2(2), CDK4(3), CDKN1A(1), CDKN2A(2), CHEK1(2), CHEK2(14), DTX4(4), E2F1(9), E2F2(3), E2F3(4), E2F4(3), E2F5(6), E2F6(1), EP300(32), ESPL1(11), GSK3B(13), HDAC1(5), HDAC2(5), HDAC3(12), HDAC4(14), HDAC5(12), HDAC6(25), HDAC8(2), MAD1L1(12), MAD2L1(4), MAD2L2(2), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(4), MPEG1(9), MPL(7), PCNA(3), PLK1(4), PRKDC(54), PTPRA(10), PTTG1(2), PTTG2(1), RB1(26), RBL1(14), SKP2(7), SMAD4(5), TBC1D8(15), TFDP1(13), TGFB1(2), TP53(74), WEE1(2)	40838039	745	158	703	199	224	243	142	5	122	9	0.0189	1.000	1.000
291	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRB2(7), ADRB3(3), ANXA6(11), ARRB1(4), ARRB2(4), ATP1A4(24), ATP1B1(6), ATP1B2(5), ATP1B3(3), ATP2A2(8), ATP2A3(11), ATP2B1(15), ATP2B2(12), ATP2B3(17), CACNA1A(20), CACNA1B(35), CACNA1C(38), CACNA1D(29), CACNA1E(60), CACNA1S(33), CACNB1(12), CACNB3(5), CALM1(2), CALM2(4), CALR(3), CAMK1(2), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CASQ1(8), CASQ2(9), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), FXYD2(3), GJA1(5), GJA4(1), GJA5(6), GJB1(3), GJB2(3), GJB3(4), GJB4(6), GJB5(2), GJB6(3), GNA11(2), GNAI2(6), GNAI3(4), GNAO1(7), GNAQ(3), GNAZ(4), GNB1(2), GNB2(7), GNB3(2), GNB4(4), GNB5(3), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GRK4(10), GRK5(10), GRK6(2), ITPR1(36), ITPR2(35), ITPR3(21), KCNB1(13), KCNJ3(9), KCNJ5(7), MIB1(9), MYCBP(2), NME7(4), PEA15(2), PKIA(1), PLCB3(11), PLN(2), PRKACA(6), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), PRKCZ(3), PRKD1(8), RGS1(6), RGS10(2), RGS11(1), RGS14(4), RGS16(5), RGS17(4), RGS18(3), RGS19(3), RGS2(3), RGS20(2), RGS3(11), RGS4(8), RGS5(4), RGS6(11), RGS7(9), RGS9(11), RYR1(72), RYR2(111), RYR3(94), SLC8A1(13), SLC8A3(13), USP5(13), YWHAH(3), YWHAQ(1)	69521324	1391	155	1359	526	490	514	222	11	145	9	0.412	1.000	1.000
292	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(12), BRAF(10), CACNA1A(20), CRH(1), CRHR1(3), GNA11(2), GNA12(8), GNA13(7), GNAI1(5), GNAI2(6), GNAI3(4), GNAO1(7), GNAQ(3), GNAS(24), GNAZ(4), GRIA1(13), GRIA2(20), GRIA3(22), GRID2(16), GRM1(29), GRM5(27), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), HRAS(1), IGF1(5), IGF1R(13), ITPR1(36), ITPR2(35), ITPR3(21), KRAS(53), LYN(9), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NOS1(18), NOS3(11), NPR1(12), NPR2(11), NRAS(9), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PRKCA(10), PRKCG(8), PRKG1(11), PRKG2(11), RAF1(8), RYR1(72)	40168024	843	150	765	273	258	356	134	9	83	3	0.0700	1.000	1.000
293	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(3), ACTG1(6), CHAD(3), COL11A1(37), COL11A2(10), COL17A1(20), COL1A1(12), COL1A2(24), COL2A1(15), COL3A1(19), COL4A1(21), COL4A2(12), COL4A4(24), COL4A6(32), COL5A1(29), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(14), COL6A3(45), COL6A6(27), COMP(6), DES(6), DSC1(18), DSC2(14), DSC3(20), DSG1(24), DSG2(15), DSG3(23), DSG4(16), FN1(43), GJA1(5), GJA10(10), GJA3(5), GJA4(1), GJA5(6), GJA8(6), GJA9(15), GJB1(3), GJB2(3), GJB3(4), GJB4(6), GJB5(2), GJB6(3), GJB7(8), GJC1(2), GJC3(2), GJD2(8), GJD4(3), IBSP(7), INA(5), ITGA6(12), ITGB4(8), KRT1(8), KRT10(3), KRT12(8), KRT13(6), KRT14(9), KRT15(10), KRT16(8), KRT17(4), KRT18(1), KRT19(6), KRT2(7), KRT20(4), KRT23(11), KRT24(5), KRT25(7), KRT27(4), KRT28(4), KRT3(9), KRT31(8), KRT32(10), KRT33A(7), KRT33B(5), KRT34(8), KRT35(9), KRT36(7), KRT37(8), KRT38(8), KRT39(14), KRT4(11), KRT40(5), KRT5(6), KRT6A(5), KRT6B(9), KRT6C(8), KRT7(3), KRT71(5), KRT72(6), KRT73(7), KRT74(1), KRT75(4), KRT76(6), KRT77(7), KRT78(5), KRT79(5), KRT8(7), KRT81(4), KRT82(1), KRT83(3), KRT84(7), KRT85(6), KRT86(1), KRT9(8), LAMA1(32), LAMA2(61), LAMA3(30), LAMA4(15), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(16), LAMB4(32), LAMC1(18), LAMC2(17), LAMC3(17), LMNA(8), LMNB1(5), LMNB2(4), NES(28), RELN(48), SPP1(2), THBS1(11), THBS2(20), THBS3(3), THBS4(12), TNC(26), TNN(19), TNR(15), TNXB(19), VIM(8), VTN(3), VWF(25)	88632952	1595	148	1560	530	488	635	260	20	177	15	0.0832	1.000	1.000
294	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ATF4(3), CACNA1C(38), CACNA1D(29), CACNA1F(41), CACNA1S(33), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CDC42(4), CGA(1), EGFR(12), ELK1(3), GNA11(2), GNAQ(3), GNAS(24), GNRH1(1), GNRH2(1), GNRHR(4), GRB2(3), HBEGF(2), HRAS(1), ITPR1(36), ITPR2(35), ITPR3(21), JUN(1), KRAS(53), LHB(2), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK7(14), MAPK8(10), MAPK9(5), MMP14(6), MMP2(7), NRAS(9), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLD1(14), PLD2(10), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCD(5), PRKX(2), PTK2B(16), RAF1(8), SOS1(13), SOS2(17), SRC(3)	46763646	931	142	860	286	323	333	151	13	104	7	0.00558	1.000	1.000
295	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(56), AXIN1(9), CCND1(15), CCND2(9), CCND3(4), CSNK1E(3), CTNNB1(80), DVL1(3), DVL2(10), DVL3(9), FBXW2(4), FOSL1(3), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GSK3B(13), JUN(1), LDLR(6), MAPK10(9), MAPK9(5), MYC(8), PAFAH1B1(2), PLAU(6), PPP2R5C(7), PPP2R5E(8), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(3), PRKD1(8), RAC1(1), RHOA(3), SFRP4(9), TCF7(3), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(8), WNT3(3), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2)	20506676	460	141	390	147	138	176	87	4	51	4	0.109	1.000	1.000
296	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(11), CD36(8), CD44(5), CD47(6), CHAD(3), COL11A1(37), COL11A2(10), COL1A1(12), COL1A2(24), COL2A1(15), COL3A1(19), COL4A1(21), COL4A2(12), COL4A4(24), COL4A6(32), COL5A1(29), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(14), COL6A3(45), COL6A6(27), DAG1(6), FN1(43), FNDC1(34), FNDC3A(7), FNDC4(3), FNDC5(2), GP5(3), GP6(5), GP9(1), HMMR(12), HSPG2(24), IBSP(7), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAV(10), ITGB1(8), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), LAMA1(32), LAMA2(61), LAMA3(30), LAMA4(15), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(16), LAMB4(32), LAMC1(18), LAMC2(17), LAMC3(17), RELN(48), SDC1(1), SDC2(1), SDC3(2), SDC4(4), SPP1(2), SV2A(14), SV2B(13), SV2C(17), THBS1(11), THBS2(20), THBS3(3), THBS4(12), TNC(26), TNN(19), TNR(15), TNXB(19), VTN(3), VWF(25)	79695637	1321	140	1292	457	394	529	212	16	155	15	0.333	1.000	1.000
297	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(5), ACTA2(7), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADM(2), ARRB1(4), ARRB2(4), ATF1(6), ATF2(8), ATF3(3), ATF4(3), ATF5(6), ATP2A2(8), ATP2A3(11), CACNB3(5), CALCA(2), CALM1(2), CALM2(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CNN1(3), CNN2(1), CORIN(13), CRH(1), CRHR1(3), DGKZ(10), ETS2(6), FOS(3), GABPA(8), GABPB2(12), GBA2(13), GJA1(5), GNAQ(3), GNB1(2), GNB2(7), GNB3(2), GNB4(4), GNB5(3), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GRK4(10), GRK5(10), GRK6(2), GSTO1(3), GUCA2B(1), GUCY1A3(11), IGFBP1(4), IGFBP2(5), IGFBP3(4), IGFBP4(3), IGFBP6(2), IL1B(2), IL6(5), ITPR1(36), ITPR2(35), ITPR3(21), JUN(1), MIB1(9), MYL2(2), MYLK2(8), NFKB1(10), NOS1(18), NOS3(11), OXTR(4), PDE4B(14), PDE4D(9), PKIA(1), PLCB3(11), PLCD1(5), PLCG1(12), PLCG2(29), PRKACA(6), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCH(10), PRKCQ(9), PRKCZ(3), PRKD1(8), RAMP1(1), RAMP3(2), RGS1(6), RGS10(2), RGS11(1), RGS14(4), RGS16(5), RGS17(4), RGS18(3), RGS19(3), RGS2(3), RGS20(2), RGS3(11), RGS4(8), RGS5(4), RGS6(11), RGS7(9), RGS9(11), RLN1(1), RYR1(72), RYR2(111), RYR3(94), SLC8A1(13), SP1(7), TNXB(19), USP5(13), YWHAH(3), YWHAQ(1)	62417276	1167	137	1135	437	387	439	203	7	124	7	0.580	1.000	1.000
298	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	ALG2(2), BAK1(3), BAX(3), BFAR(7), BTK(12), CAD(25), CASP10(8), CASP3(4), CASP8(21), CD7(3), CDK2AP1(1), CSNK1A1(4), DAXX(10), DEDD(2), DEDD2(2), DIABLO(2), EGFR(12), EPHB2(12), FADD(1), FAF1(10), FAIM2(3), IL8(3), MAP2K4(9), MAP2K7(4), MAP3K1(30), MAP3K5(25), MAPK1(2), MAPK10(9), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5), MET(17), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), NR0B2(2), PFN1(1), PFN2(2), PTPN13(30), RALBP1(6), RIPK1(9), ROCK1(22), SMPD1(11), TP53(74), TPX2(12), TRAF2(3), TUFM(5)	24662302	500	137	465	126	136	182	82	2	93	5	0.00658	1.000	1.000
299	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	246	ACVR1(11), ACVR1B(9), ACVR2A(7), ACVR2B(5), AMHR2(3), BMP2(6), BMP7(12), BMPR1A(5), BMPR1B(6), BMPR2(12), CCL1(1), CCL13(2), CCL14(1), CCL15(1), CCL16(1), CCL17(1), CCL18(1), CCL21(1), CCL23(3), CCL24(3), CCL25(1), CCL28(2), CCL4(5), CCL5(2), CCL7(4), CCL8(3), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CCR9(4), CD27(4), CD40(4), CD40LG(6), CD70(2), CLCF1(1), CNTF(3), CNTFR(2), CRLF2(5), CSF1(6), CSF1R(8), CSF2(1), CSF2RA(12), CSF2RB(14), CSF3(1), CSF3R(8), CX3CL1(3), CX3CR1(6), CXCL1(3), CXCL10(2), CXCL12(6), CXCL13(2), CXCL16(2), CXCL2(2), CXCL3(1), CXCL5(3), CXCL9(2), CXCR3(5), CXCR4(1), CXCR6(1), EDA(5), EDA2R(6), EDAR(5), EGF(20), EGFR(12), EPO(2), EPOR(4), FAS(9), FASLG(7), FLT1(20), FLT3(16), FLT3LG(2), FLT4(9), GDF5(7), GH1(3), GH2(3), GHR(8), HGF(14), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(9), IFNGR1(5), IFNGR2(4), IFNK(2), IFNW1(3), IL10(3), IL10RA(4), IL10RB(6), IL11(2), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL13RA1(13), IL15(2), IL17RA(5), IL17RB(5), IL18(2), IL18R1(9), IL18RAP(15), IL19(2), IL1B(2), IL1R1(5), IL1R2(5), IL1RAP(8), IL2(2), IL20(9), IL20RA(3), IL21(3), IL21R(7), IL22RA1(4), IL22RA2(1), IL23A(4), IL23R(5), IL24(7), IL25(2), IL26(3), IL28A(3), IL28B(2), IL28RA(9), IL29(2), IL2RA(4), IL2RB(3), IL2RG(13), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL6ST(11), IL7(1), IL7R(12), IL8(3), IL9(1), IL9R(8), INHBA(8), INHBB(2), INHBC(3), INHBE(6), KDR(26), KIT(24), KITLG(3), LEP(2), LEPR(12), LIF(3), LIFR(27), LTA(3), LTBR(5), MET(17), MPL(7), NGFR(3), OSM(2), OSMR(13), PDGFB(2), PDGFC(3), PDGFRA(24), PDGFRB(12), PF4(1), PF4V1(1), PLEKHO2(6), PPBP(1), PRL(6), PRLR(5), RELT(2), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFRSF11A(4), TNFRSF11B(13), TNFRSF13B(3), TNFRSF14(2), TNFRSF17(1), TNFRSF19(4), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(3), TNFRSF8(8), TNFRSF9(2), TNFSF10(1), TNFSF11(7), TNFSF12(4), TNFSF13B(5), TNFSF14(2), TNFSF15(3), TNFSF18(4), TNFSF4(4), TNFSF8(1), TNFSF9(6), TPO(15), TSLP(2), VEGFA(2), VEGFB(2), VEGFC(6), XCL2(2), XCR1(3)	63931396	1176	135	1154	362	307	472	236	6	150	5	0.0220	1.000	1.000
300	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), AKAP1(9), AKAP10(9), AKAP11(23), AKAP12(21), AKAP3(21), AKAP4(15), AKAP5(3), AKAP6(34), AKAP7(7), AKAP8(5), AKAP9(54), ARHGEF1(12), CALM1(2), CALM2(4), CHMP1B(1), GNA11(2), GNA12(8), GNA13(7), GNA14(7), GNA15(2), GNAI2(6), GNAI3(4), GNAL(6), GNAO1(7), GNAQ(3), GNAZ(4), GNB1(2), GNB2(7), GNB3(2), GNB5(3), GNG12(1), GNG13(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GNGT2(3), HRAS(1), IL18BP(1), ITPR1(36), KCNJ3(9), KRAS(53), NRAS(9), PALM2(7), PDE1A(15), PDE1B(7), PDE1C(12), PDE4A(10), PDE4B(14), PDE4C(2), PDE4D(9), PDE7A(1), PDE7B(7), PDE8A(7), PDE8B(19), PLCB3(11), PPP3CA(4), PPP3CC(6), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(3), PRKD1(8), PRKD3(11), RHOA(3), RRAS(3), SLC9A1(8), USP5(13)	42506319	836	134	772	302	262	294	173	6	97	4	0.575	1.000	1.000
301	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	127	ALCAM(7), CADM1(4), CADM3(10), CD2(4), CD22(14), CD226(6), CD274(1), CD276(2), CD28(3), CD34(1), CD4(6), CD40(4), CD40LG(6), CD58(2), CD6(6), CD80(5), CD86(5), CD8A(2), CD8B(1), CD99(1), CDH1(14), CDH15(8), CDH2(19), CDH3(6), CDH4(17), CDH5(6), CLDN1(3), CLDN10(8), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CNTN1(18), CNTN2(6), CNTNAP1(12), CNTNAP2(31), CTLA4(2), ESAM(1), F11R(1), GLG1(8), HLA-A(1), HLA-B(4), HLA-C(2), HLA-DMA(3), HLA-DOA(3), HLA-DOB(3), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB5(2), HLA-E(1), HLA-F(3), HLA-G(2), ICAM1(2), ICAM2(3), ICAM3(3), ICOS(3), ICOSLG(2), ITGA4(10), ITGA6(12), ITGA8(20), ITGA9(16), ITGAL(17), ITGAM(21), ITGAV(10), ITGB1(8), ITGB2(14), ITGB7(4), ITGB8(9), JAM2(9), JAM3(3), L1CAM(20), MADCAM1(2), MAG(7), MPZ(3), MPZL1(3), NCAM1(9), NCAM2(33), NEGR1(7), NEO1(17), NFASC(33), NLGN1(9), NLGN2(7), NLGN3(25), NRCAM(14), NRXN1(36), NRXN2(17), NRXN3(29), OCLN(2), PDCD1(3), PDCD1LG2(1), PTPRC(17), PTPRF(27), PTPRM(15), PVR(3), PVRL1(10), PVRL2(5), PVRL3(7), SDC1(1), SDC2(1), SDC3(2), SDC4(4), SELE(5), SELL(5), SELP(12), SELPLG(9), SIGLEC1(12), SPN(1), VCAM1(12), VCAN(66)	51647538	975	132	946	324	304	376	165	5	116	9	0.0352	1.000	1.000
302	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), CSNK1D(3), DRD1(7), DRD2(8), EGF(20), EGFR(12), GJA1(5), GJD2(8), GNA11(2), GNAI1(5), GNAI2(6), GNAI3(4), GNAQ(3), GNAS(24), GRB2(3), GRM1(29), GRM5(27), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), HRAS(1), HTR2A(11), HTR2B(2), HTR2C(17), ITPR1(36), ITPR2(35), ITPR3(21), KRAS(53), MAP2K1(2), MAP2K2(5), MAP2K5(3), MAP3K2(12), MAPK1(2), MAPK3(3), MAPK7(14), NPR1(12), NPR2(11), NRAS(9), PDGFA(3), PDGFB(2), PDGFC(3), PDGFD(8), PDGFRA(24), PDGFRB(12), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKG1(11), PRKG2(11), PRKX(2), RAF1(8), SOS1(13), SOS2(17), SRC(3), TJP1(24), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(11), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4)	47468487	947	132	878	294	289	363	182	12	98	3	0.0120	1.000	1.000
303	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(21), ADCY8(22), ARAF(12), ATF4(3), BRAF(10), CACNA1C(38), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), CREBBP(32), EP300(32), GNAQ(3), GRIA1(13), GRIA2(20), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), GRM1(29), GRM5(27), HRAS(1), ITPR1(36), ITPR2(35), ITPR3(21), KRAS(53), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NRAS(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PPP1CA(3), PPP1CB(9), PPP1CC(4), PPP1R12A(8), PPP1R1A(4), PPP3CA(4), PPP3CB(5), PPP3CC(6), PPP3R1(1), PPP3R2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(10), PRKCG(8), PRKX(2), RAF1(8), RAP1A(4), RAP1B(2), RAPGEF3(10), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA6(19)	36763828	739	132	673	246	224	281	144	7	80	3	0.154	1.000	1.000
304	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(2), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADK(2), ADSL(8), ADSS(6), ADSSL1(5), AK1(1), AK2(3), AK5(8), AK7(13), ALLC(8), AMPD1(23), AMPD2(6), AMPD3(7), ATIC(7), CANT1(1), DCK(5), ENPP1(12), ENPP3(18), ENTPD1(3), ENTPD3(5), ENTPD4(2), ENTPD5(2), ENTPD6(10), ENTPD8(5), FHIT(4), GART(9), GDA(4), GMPR(6), GMPR2(3), GMPS(14), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), GUK1(7), HPRT1(2), IMPDH1(6), IMPDH2(5), ITPA(1), NME1(2), NME4(2), NME6(2), NME7(4), NPR1(12), NPR2(11), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5C3(8), NT5E(6), NT5M(3), NUDT2(2), NUDT5(2), NUDT9(1), PAICS(4), PAPSS1(8), PAPSS2(7), PDE10A(15), PDE11A(12), PDE1A(15), PDE1C(12), PDE2A(14), PDE3B(15), PDE4A(10), PDE4B(14), PDE4C(2), PDE4D(9), PDE5A(14), PDE6D(2), PDE6G(1), PDE6H(1), PDE7A(1), PDE7B(7), PDE8A(7), PDE8B(19), PDE9A(9), PFAS(11), PKLR(7), PKM2(5), PNPT1(7), POLA1(29), POLA2(3), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(3), POLR3H(5), PPAT(9), PRIM1(3), PRPS1(3), PRPS1L1(5), PRPS2(7), PRUNE(5), RFC5(8), RRM1(2), RRM2(7), RRM2B(5), XDH(14)	59133569	1060	129	1026	319	334	363	207	12	143	1	0.0262	1.000	1.000
305	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	149	ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(5), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRA2A(6), ADRA2C(2), ADRB2(7), ADRB3(3), AGTR1(4), AGTR2(11), AVPR1A(7), AVPR1B(3), AVPR2(5), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), CCBP2(3), CCKAR(9), CCKBR(3), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CCR9(4), CCRL1(7), CCRL2(1), CHML(10), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CMKLR1(9), CNR1(12), CNR2(6), CX3CR1(6), CXCR3(5), CXCR4(1), DRD1(7), DRD2(8), DRD3(6), DRD5(11), EDNRA(5), EDNRB(4), F2R(6), F2RL1(4), F2RL2(2), FPR1(2), FSHR(17), GALR1(3), GALR3(2), GALT(3), GHSR(8), GNB2L1(1), GPR17(6), GPR173(6), GPR174(12), GPR3(5), GPR35(3), GPR37(9), GPR37L1(6), GPR4(9), GPR50(8), GPR6(4), GPR63(5), GPR77(2), GPR83(3), GPR85(7), GPR87(7), GRPR(4), HCRTR2(11), HRH1(10), HRH2(4), HRH3(2), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5), LHCGR(17), LTB4R(2), MAS1(3), MC1R(3), MC3R(5), MC4R(5), MC5R(14), MLNR(5), MTNR1A(5), MTNR1B(4), NMBR(4), NMUR1(4), NMUR2(8), NPY1R(9), NPY2R(5), NPY5R(13), NTSR1(5), NTSR2(1), OPN1SW(6), OPN3(2), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(13), OXTR(4), P2RY1(3), P2RY10(8), P2RY11(7), P2RY12(5), P2RY13(2), P2RY14(6), P2RY2(3), P2RY6(4), PPYR1(8), PTAFR(4), PTGDR(9), PTGER2(3), PTGER4(12), PTGFR(13), PTGIR(3), RGR(6), RHO(4), RRH(2), SSTR1(10), SSTR2(3), SSTR3(3), SSTR4(10), SUCNR1(3), TRHR(3)	39736749	882	126	857	312	298	362	144	11	67	0	0.00445	1.000	1.000
306	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(4), AKT2(6), AKT3(11), ANKRD6(8), APC(56), AXIN1(9), AXIN2(9), CER1(4), CSNK1A1(4), CTNNB1(80), DACT1(14), DKK1(3), DKK2(3), DKK3(1), DKK4(3), DVL1(3), FSTL1(3), GSK3A(10), GSK3B(13), LRP1(51), MVP(14), NKD1(3), PSEN1(5), PTPRA(10), SENP2(12), SFRP1(6), TSHB(3), WIF1(5)	14398562	353	126	287	95	111	148	53	2	36	3	0.0107	1.000	1.000
307	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(4), ATF2(8), CDC42(4), DLD(5), DUSP10(5), DUSP8(1), GAB1(8), GCK(3), IL1R1(5), JUN(1), MAP2K4(9), MAP2K5(3), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K11(6), MAP3K12(8), MAP3K13(13), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAP3K5(25), MAP3K7(9), MAP3K9(6), MAPK10(9), MAPK7(14), MAPK8(10), MAPK9(5), MYEF2(6), NFATC3(12), NR2C2(7), PAPPA(27), SHC1(7), TP53(74), TRAF6(7), ZAK(15)	17971185	399	123	371	98	128	136	67	4	61	3	0.0186	1.000	1.000
308	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	86	ACVR1(11), ACVR1B(9), ACVR1C(6), ACVR2A(7), ACVR2B(5), ACVRL1(2), AMHR2(3), BMP2(6), BMP4(10), BMP5(14), BMP6(5), BMP7(12), BMP8A(3), BMP8B(1), BMPR1A(5), BMPR1B(6), BMPR2(12), CHRD(11), COMP(6), CREBBP(32), CUL1(13), DCN(11), E2F4(3), E2F5(6), EP300(32), FST(4), GDF5(7), GDF6(4), ID1(2), ID2(1), IFNG(9), INHBA(8), INHBB(2), INHBC(3), INHBE(6), LEFTY1(4), LEFTY2(1), LTBP1(17), MAPK1(2), MAPK3(3), MYC(8), NODAL(3), NOG(2), PITX2(12), PPP2CA(6), PPP2CB(4), PPP2R1A(30), PPP2R1B(6), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), RBL1(14), RBL2(19), RBX1(1), RHOA(3), ROCK1(22), ROCK2(17), RPS6KB1(5), RPS6KB2(4), SMAD1(2), SMAD2(9), SMAD3(7), SMAD4(5), SMAD5(11), SMAD7(3), SMAD9(2), SMURF1(12), SMURF2(7), SP1(7), TFDP1(13), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), THBS1(11), THBS2(20), THBS3(3), THBS4(12), ZFYVE16(18), ZFYVE9(18)	35156888	671	122	637	186	236	222	123	4	82	4	0.0132	1.000	1.000
309	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(42), ASH2L(12), CARM1(5), CTCFL(13), DOT1L(8), EED(12), EHMT1(23), EHMT2(2), EZH1(10), EZH2(15), FBXO11(8), HCFC1(26), HSF4(3), JMJD4(4), JMJD6(5), KDM6A(14), MEN1(9), MLL(32), MLL2(57), MLL3(56), MLL4(54), MLL5(25), NSD1(37), OGT(17), PAXIP1(10), PPP1CA(3), PPP1CB(9), PPP1CC(4), PRDM2(19), PRDM6(6), PRDM7(2), PRDM9(31), PRMT1(4), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), RBBP5(7), SATB1(18), SETD1A(12), SETD1B(17), SETD2(36), SETD7(7), SETD8(3), SETDB1(16), SETDB2(14), SETMAR(6), SMYD3(6), STK38(9), SUV39H1(9), SUV39H2(5), SUV420H1(16), SUZ12(12), WHSC1(19), WHSC1L1(17)	44102583	833	121	808	236	258	275	160	10	124	6	0.0546	1.000	1.000
310	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(5), ACTA2(7), ACTN2(16), ACTN3(10), ACTN4(8), DES(6), DMD(92), FAM48A(5), MYBPC1(16), MYBPC2(13), MYBPC3(13), MYH3(30), MYH6(16), MYH7(35), MYH8(30), MYL1(5), MYL2(2), MYL3(1), MYL9(3), MYOM1(36), NEB(123), TMOD1(4), TNNC2(3), TNNI1(1), TNNI2(4), TNNI3(4), TNNT1(4), TNNT2(8), TNNT3(4), TPM1(3), TPM2(1), TPM3(5), TPM4(4), TTN(526), VIM(8)	52150257	1051	121	1016	333	292	439	227	4	60	29	0.541	1.000	1.000
311	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADK(2), ADSL(8), ADSS(6), AK1(1), AK2(3), AK5(8), ALLC(8), AMPD1(23), AMPD2(6), AMPD3(7), ATIC(7), ATP1B1(6), ATP5A1(8), ATP5B(5), ATP5C1(1), ATP5D(1), ATP5F1(4), ATP5G1(3), ATP5G2(1), ATP5G3(1), ATP5H(1), ATP5I(2), ATP5J(3), CANT1(1), DCK(5), ENPP1(12), ENPP3(18), ENTPD1(3), FHIT(4), GART(9), GDA(4), GMPS(14), GUCY1A2(10), GUCY1A3(11), GUCY1B3(8), GUCY2C(14), GUCY2D(7), GUCY2F(26), GUK1(7), HPRT1(2), IMPDH1(6), IMPDH2(5), ITPA(1), NME1(2), NPR1(12), NPR2(11), NT5C(1), NT5E(6), NT5M(3), NUDT2(2), PAICS(4), PAPSS1(8), PAPSS2(7), PDE1A(15), PDE4A(10), PDE4B(14), PDE4C(2), PDE4D(9), PDE5A(14), PDE6B(5), PDE6C(13), PDE6G(1), PDE7B(7), PDE8A(7), PDE9A(9), PFAS(11), PKLR(7), PKM2(5), POLB(4), POLD1(12), POLD2(6), POLE(47), POLG(6), POLL(7), POLQ(29), POLR1B(16), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLRMT(11), PPAT(9), PRPS1(3), PRPS1L1(5), PRPS2(7), PRUNE(5), RRM1(2), RRM2(7)	46086103	830	117	805	257	264	303	155	6	101	1	0.106	1.000	1.000
312	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(4), AKT3(11), BCAR1(8), CAPN1(5), CAPN10(9), CAPN11(9), CAPN2(11), CAPN3(11), CAPN5(9), CAPN6(13), CAPN7(8), CAPN9(11), CAPNS1(2), CAV1(2), CAV2(1), CDC42(4), CRK(2), CSK(1), DOCK1(24), FYN(7), GIT2(9), GRB2(3), ILK(5), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(20), ITGA9(16), ITGAD(10), ITGAE(9), ITGAL(17), ITGAM(21), ITGAV(10), ITGAX(14), ITGB1(8), ITGB2(14), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAPK10(9), MAPK12(3), MAPK4(4), MAPK6(11), MAPK7(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PDPK1(3), PIK3R2(7), PTK2(12), PXN(6), RAC1(1), RAC2(3), RAP1B(2), RAPGEF1(11), RHO(4), ROCK1(22), ROCK2(17), SDCCAG8(13), SEPP1(3), SHC1(7), SHC3(15), SORBS1(18), SOS1(13), SRC(3), TLN1(23), TNS1(23), VASP(3), VAV2(7), VAV3(14), VCL(11), ZYX(11)	48776737	805	115	779	290	257	298	140	6	98	6	0.587	1.000	1.000
313	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(2), CDC40(9), CLK2(9), CLK3(6), CLK4(6), COL2A1(15), CPSF1(11), CPSF2(14), CPSF3(8), CPSF4(1), CSTF1(4), CSTF2(13), CSTF2T(5), CSTF3(10), DDIT3(2), DDX1(5), DDX20(4), DHX15(9), DHX16(11), DHX38(10), DHX8(9), DHX9(14), DICER1(36), DNAJC8(1), FUS(3), GIPC1(2), METTL3(6), NCBP1(9), NCBP2(4), NONO(18), NXF1(4), PABPN1(3), PAPOLA(13), PHF5A(1), POLR2A(21), PPM1G(9), PRPF18(5), PRPF3(10), PRPF4(5), PRPF4B(17), PRPF8(26), PSKH1(8), PTBP1(3), PTBP2(9), RBM17(4), RBM5(6), RNGTT(11), RNMT(7), RNPS1(3), SF3A1(4), SF3A2(2), SF3A3(8), SF3B1(18), SF3B2(9), SF3B4(4), SF3B5(2), SNRPA(2), SNRPB(2), SNRPB2(1), SNRPD1(1), SNRPD2(1), SNRPD3(3), SNRPE(1), SNRPG(1), SNRPN(4), SNURF(1), SPOP(23), SRPK1(11), SRPK2(6), SRRM1(12), SUPT5H(19), U2AF1(4), U2AF2(7), XRN2(19)	38070878	586	112	563	175	202	191	121	3	67	2	0.580	1.000	1.000
314	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(30), ABCA10(27), ABCA12(54), ABCA13(80), ABCA2(10), ABCA3(12), ABCA4(28), ABCA5(30), ABCA6(24), ABCA7(17), ABCA8(27), ABCA9(28), ABCB1(32), ABCB10(10), ABCB11(15), ABCB4(28), ABCB5(32), ABCB6(11), ABCB7(17), ABCB8(6), ABCB9(7), ABCC1(14), ABCC10(10), ABCC11(27), ABCC12(20), ABCC2(30), ABCC3(13), ABCC4(16), ABCC5(15), ABCC6(13), ABCC8(21), ABCC9(29), ABCD1(12), ABCD2(7), ABCD3(9), ABCD4(2), ABCG1(12), ABCG2(16), ABCG4(7), ABCG5(5), ABCG8(7), CFTR(14), TAP1(8), TAP2(1)	42524165	833	108	806	227	230	334	149	3	107	10	8.04e-05	1.000	1.000
315	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(7), ALG1(2), ALG10(6), ALG10B(6), ALG11(6), ALG12(7), ALG13(24), ALG14(2), ALG2(2), ALG3(1), ALG6(5), ALG8(10), ALG9(4), B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), B4GALT5(2), B4GALT7(4), C1GALT1(2), C1GALT1C1(6), CHPF(5), CHST1(8), CHST11(8), CHST12(3), CHST14(3), CHST2(2), CHST3(4), CHST4(4), CHST6(6), CHST7(4), CHSY1(8), DAD1(2), DDOST(3), DPAGT1(3), EXT1(12), EXT2(6), EXTL1(9), EXTL2(8), EXTL3(10), FUT11(4), FUT8(13), GALNT1(10), GALNT10(8), GALNT11(12), GALNT12(6), GALNT13(18), GALNT14(6), GALNT2(9), GALNT3(7), GALNT4(8), GALNT5(7), GALNT6(1), GALNT7(13), GALNT8(11), GALNT9(8), GALNTL1(8), GALNTL2(17), GALNTL4(6), GALNTL5(11), GANAB(10), GCNT1(5), GCNT3(5), GCNT4(1), HS2ST1(7), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), HS3ST5(9), HS6ST1(4), HS6ST2(12), HS6ST3(3), MAN1A1(13), MAN1A2(7), MAN1B1(5), MAN1C1(6), MAN2A1(20), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), MGAT5B(10), NDST1(14), NDST2(9), NDST3(14), NDST4(15), OGT(17), RPN1(3), RPN2(5), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3), ST6GAL1(7), ST6GALNAC1(4), STT3B(5), UST(3), WBSCR17(16), XYLT1(16), XYLT2(4)	38860123	739	103	714	232	237	260	153	3	83	3	0.124	1.000	1.000
316	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(9), ACTN2(16), ACTN3(10), BCAR1(8), CSK(1), CTNNA1(18), CTNNA2(16), CTNNB1(80), PTK2(12), PXN(6), SRC(3), VCL(11)	6836403	190	100	131	52	42	93	31	2	21	1	0.0833	1.000	1.000
317	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(17), AMY2A(4), AMY2B(11), ASCC3(31), ATP13A2(5), DDX18(12), DDX19A(4), DDX23(9), DDX4(15), DDX41(3), DDX47(5), DDX50(10), DDX51(8), DDX52(4), DDX54(8), DDX55(7), DDX56(5), DHX58(6), ENPP1(12), ENPP3(18), ENTPD7(8), EP400(42), ERCC2(1), ERCC3(11), G6PC(5), G6PC2(11), GAA(4), GANC(15), GBA(4), GBA3(9), GBE1(9), GCK(3), GPI(7), GUSB(5), GYS1(13), GYS2(16), HK1(11), HK2(9), HK3(10), IFIH1(5), LYZL1(4), MGAM(51), MOV10L1(19), NUDT5(2), NUDT8(1), PGM1(7), PGM3(4), PYGB(11), PYGL(8), PYGM(10), RAD54B(14), RAD54L(5), RUVBL2(4), SETX(33), SI(65), SKIV2L2(17), SMARCA2(24), SMARCA5(19), TREH(2), UGDH(2), UGP2(6), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), UXS1(5)	45031394	856	100	828	213	232	308	201	9	100	6	0.000549	1.000	1.000
318	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(8), BRAF(10), CHUK(8), CREB1(6), DAXX(10), ELK1(3), FOS(3), GRB2(3), HRAS(1), IKBKB(13), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K5(3), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K11(6), MAP3K12(8), MAP3K13(13), MAP3K14(6), MAP3K2(12), MAP3K3(9), MAP3K4(21), MAP3K5(25), MAP3K6(7), MAP3K7(9), MAP3K8(10), MAP3K9(6), MAP4K1(11), MAP4K2(7), MAP4K3(16), MAP4K4(11), MAP4K5(7), MAPK1(2), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK3(3), MAPK4(4), MAPK6(11), MAPK7(14), MAPK8(10), MAPK9(5), MAPKAPK2(6), MAPKAPK3(5), MAPKAPK5(5), MAX(12), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), MKNK1(3), MKNK2(3), MYC(8), NFKB1(10), NFKBIA(3), PAK1(3), PAK2(3), RAC1(1), RAF1(8), RELA(6), RIPK1(9), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA4(2), RPS6KA5(11), RPS6KB1(5), RPS6KB2(4), SHC1(7), SP1(7), STAT1(15), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TRAF2(3)	34631614	615	100	599	162	190	226	108	4	83	4	0.00727	1.000	1.000
319	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	ACTB(3), BAD(2), CABIN1(19), CALM1(2), CALM2(4), CAMK2B(3), CAMK4(5), CD3E(2), CD3G(3), CD69(2), CDKN1A(1), CNR1(12), CREBBP(32), CSF2(1), CSNK2A1(9), CTLA4(2), EGR2(6), EGR3(7), EP300(32), FCER1A(9), FCGR3A(1), FKBP1B(1), FOS(3), FOSL1(3), GATA3(3), GATA4(3), GSK3A(10), GSK3B(13), HRAS(1), ICOS(3), IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL1B(2), IL2(2), IL2RA(4), IL3(2), IL4(1), IL6(5), IL8(3), ITK(7), KPNA5(7), MAP2K7(4), MAPK14(4), MAPK8(10), MAPK9(5), MEF2A(3), MEF2B(1), MEF2D(7), MYF5(6), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NFKB2(9), NFKBIB(1), NFKBIE(6), NPPB(3), NUP214(18), OPRD1(1), P2RX7(1), PAK1(3), PPIA(1), PPP3CB(5), PPP3CC(6), PPP3R1(1), PTPRC(17), RELA(6), RPL13A(1), SLA(6), SP1(7), SP3(11), TGFB1(2), TRAF2(3), TRPV6(10), VAV1(12), VAV2(7), VAV3(14), XPO5(11)	32447336	515	99	499	166	167	170	100	4	73	1	0.200	1.000	1.000
320	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(5), AK3(2), CAD(25), CANT1(1), CDA(2), CTPS(11), CTPS2(8), DCK(5), DCTD(4), DHODH(3), DPYD(20), DPYS(6), DTYMK(2), ENTPD1(3), ENTPD3(5), ENTPD4(2), ENTPD5(2), ENTPD6(10), ENTPD8(5), ITPA(1), NME1(2), NME4(2), NME6(2), NME7(4), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5C3(8), NT5E(6), NT5M(3), NUDT2(2), PNPT1(7), POLA1(29), POLA2(3), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(3), POLR3H(5), PRIM1(3), RFC5(8), RRM1(2), RRM2(7), RRM2B(5), TK1(3), TK2(6), TXNRD1(10), TXNRD2(5), UCK1(7), UCK2(5), UMPS(7), UPB1(10), UPP1(4), UPP2(4), UPRT(8)	29373971	511	99	490	156	154	178	101	5	72	1	0.130	1.000	1.000
321	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(18), BDKRB1(3), BDKRB2(8), C1QA(5), C1QB(3), C1QC(4), C1R(11), C1S(8), C2(3), C3(22), C3AR1(9), C4BPA(6), C4BPB(6), C5(18), C5AR1(3), C6(16), C7(20), C8A(9), C8B(5), C8G(1), C9(19), CD46(3), CD55(7), CD59(4), CFB(3), CFH(22), CFI(8), CPB2(7), CR1(22), CR2(24), F10(14), F11(15), F12(2), F13A1(8), F13B(17), F2(8), F2R(6), F3(6), F5(48), F7(2), F8(45), F9(14), FGA(26), FGB(7), FGG(10), KLKB1(10), KNG1(12), MASP1(15), MASP2(7), MBL2(4), PLAT(6), PLAU(6), PLAUR(7), PLG(14), PROC(5), PROS1(21), SERPINA1(4), SERPINA5(5), SERPINC1(10), SERPIND1(7), SERPINE1(5), SERPINF2(4), SERPING1(7), TFPI(9), THBD(1), VWF(25)	32691403	709	96	680	205	183	309	120	4	88	5	0.0285	1.000	1.000
322	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(6), APAF1(17), ARHGDIB(3), BAG4(5), BID(2), BIRC2(10), BIRC3(5), CASP2(6), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CFLAR(6), CHUK(8), CRADD(3), CYCS(2), DAXX(10), DFFB(4), FADD(1), GSN(5), LMNA(8), LMNB1(5), LMNB2(4), MAP2K7(4), MAP3K1(30), MAP3K14(6), MAP3K5(25), MAPK8(10), MDM2(4), NFKB1(10), NFKBIA(3), NUMA1(21), PAK2(3), PRKCD(5), PRKDC(54), PSEN1(5), PSEN2(8), PTK2(12), RASA1(30), RB1(26), RELA(6), RIPK1(9), SPTAN1(31), TNFRSF1A(4), TNFRSF1B(2), TRAF1(5), TRAF2(3)	25165677	465	95	452	132	122	167	82	6	83	5	0.183	1.000	1.000
323	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(15), CD14(2), CD19(4), CD1A(5), CD1B(2), CD1C(14), CD1D(5), CD1E(6), CD2(4), CD22(14), CD33(6), CD34(1), CD36(8), CD37(1), CD38(6), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD44(5), CD5(10), CD55(7), CD59(4), CD7(3), CD8A(2), CD8B(1), CD9(4), CR1(22), CR2(24), CSF1(6), CSF1R(8), CSF2(1), CSF2RA(12), CSF3(1), CSF3R(8), DNTT(3), EPO(2), EPOR(4), FCER2(1), FCGR1A(6), FLT3(16), FLT3LG(2), GP5(3), GP9(1), GYPA(2), HLA-DRA(1), HLA-DRB5(2), IL11(2), IL11RA(5), IL1B(2), IL1R1(5), IL1R2(5), IL2RA(4), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL7(1), IL7R(12), IL9R(8), ITGA1(17), ITGA2(19), ITGA2B(10), ITGA3(7), ITGA4(10), ITGA5(10), ITGA6(12), ITGAM(21), ITGB3(11), KIT(24), KITLG(3), MME(11), MS4A1(7), TFRC(4), THPO(7), TPO(15)	29769275	544	93	534	185	141	215	101	3	81	3	0.371	1.000	1.000
324	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(11), CREBBP(32), CTBP1(1), CTBP2(5), DLL1(7), DLL3(6), DLL4(6), DTX1(7), DTX2(4), DTX3(5), DTX3L(7), DTX4(4), DVL1(3), DVL2(10), DVL3(9), EP300(32), HDAC1(5), HDAC2(5), HES1(1), JAG1(23), JAG2(2), LFNG(2), MAML1(6), MAML2(10), MAML3(14), MFNG(3), NCOR2(23), NCSTN(9), NOTCH1(11), NOTCH2(18), NOTCH3(29), NOTCH4(12), NUMB(9), NUMBL(4), PSEN1(5), PSEN2(8), RBPJ(5), RBPJL(9), SNW1(6)	22970247	368	90	357	126	135	110	59	6	57	1	0.329	1.000	1.000
325	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(29), ACSL1(14), ACSL3(7), ACSL4(21), ACSL5(9), ACSL6(12), ADIPOQ(2), ADIPOR1(3), ADIPOR2(7), AGRP(2), AKT1(4), AKT2(6), AKT3(11), CAMKK1(13), CAMKK2(7), CD36(8), CHUK(8), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), G6PC(5), G6PC2(11), IKBKB(13), IKBKG(4), IRS1(13), IRS4(21), JAK1(20), JAK2(17), JAK3(10), LEP(2), LEPR(12), MAPK10(9), MAPK8(10), MAPK9(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NPY(2), PCK1(9), PCK2(7), POMC(4), PPARA(1), PPARGC1A(9), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKAG1(3), PRKAG2(4), PRKAG3(6), PRKCQ(9), PTPN11(8), RELA(6), RXRA(3), RXRG(8), SLC2A1(2), SLC2A4(9), STAT3(10), STK11(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3), TYK2(10)	28958077	524	90	512	189	153	200	96	5	64	6	0.589	1.000	1.000
326	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(12), CD28(3), CD3D(6), CSK(1), CTLA4(2), DAG1(6), DTYMK(2), EPHB2(12), FBXW7(46), GRB2(3), ITK(7), ITPKA(1), ITPKB(12), LCK(5), LCP2(5), MAPK1(2), NCK1(4), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PLCG1(12), PTPRC(17), RAF1(8), RASGRP1(8), RASGRP2(4), RASGRP3(13), RASGRP4(6), SOS1(13), SOS2(17), VAV1(12), ZAP70(9)	19923014	331	89	307	115	105	119	55	4	46	2	0.682	1.000	1.000
327	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(2), CAD(25), CANT1(1), CDA(2), CTPS(11), CTPS2(8), DCK(5), DCTD(4), DHODH(3), DPYD(20), DPYS(6), DTYMK(2), ENTPD1(3), ITPA(1), NME1(2), NT5C(1), NT5E(6), NT5M(3), NUDT2(2), POLB(4), POLD1(12), POLD2(6), POLE(47), POLG(6), POLL(7), POLQ(29), POLR1B(16), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLRMT(11), RRM1(2), RRM2(7), TK1(3), TK2(6), TXNRD1(10), UCK1(7), UCK2(5), UMPS(7), UNG(3), UPB1(10), UPP1(4)	20573408	370	86	352	108	112	144	66	1	46	1	0.0818	1.000	1.000
328	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	48	ADORA3(5), ALG6(5), CCKBR(3), CCR2(5), CCR3(4), CCR5(6), CELSR1(23), CELSR2(22), CELSR3(28), CHRM2(10), CHRM3(8), CIDEB(2), CXCR3(5), EDNRA(5), EMR2(6), EMR3(4), F2R(6), FSHR(17), GHRHR(2), GNRHR(4), GPR116(21), GPR132(6), GPR133(16), GPR135(4), GPR143(4), GPR17(6), GPR18(3), GPR55(3), GPR56(3), GPR61(4), GPR77(2), GPR84(3), GRM1(29), GRPR(4), HRH4(5), LGR6(13), LPHN2(22), LPHN3(22), LTB4R2(4), NTSR1(5), P2RY11(7), P2RY13(2), PTGFR(13), SMO(9), SSTR2(3), TAAR5(5), TSHR(8), VN1R1(5)	22229698	401	85	397	151	115	174	62	3	46	1	0.390	1.000	1.000
329	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(4), AKT2(6), AKT3(11), ASAH1(7), BRAF(10), DAG1(6), DRD2(8), EGFR(12), EPHB2(12), GRB2(3), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), PI3(2), PIK3CB(17), PITX2(12), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), RAF1(8), RGS20(2), SHC1(7), SOS1(13), SOS2(17), SRC(3), STAT3(10), TERF2IP(2)	21223221	342	84	330	139	107	130	58	5	40	2	0.924	1.000	1.000
330	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(4), ADAM17(11), ATP6AP1(8), ATP6V0A1(7), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), CASP3(4), CCL5(2), CDC42(4), CHUK(8), CSK(1), CXCL1(3), EGFR(12), F11R(1), GIT1(9), HBEGF(2), IGSF5(6), IKBKB(13), IKBKG(4), IL8(3), JAM2(9), JAM3(3), JUN(1), LYN(9), MAP2K4(9), MAP3K14(6), MAPK10(9), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPK8(10), MAPK9(5), MET(17), NFKB1(10), NFKB2(9), NFKBIA(3), NOD1(9), PAK1(3), PLCG1(12), PLCG2(29), PTPN11(8), PTPRZ1(46), RAC1(1), RELA(6), SRC(3), TCIRG1(6), TJP1(24)	25714605	474	83	467	148	123	194	84	2	68	3	0.258	1.000	1.000
331	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(4), APC(56), ASAH1(7), CAMP(1), DAG1(6), DLG4(11), EPHB2(12), GNAI1(5), GNAQ(3), ITPR1(36), ITPR2(35), ITPR3(21), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), PITX2(12), PTX3(2), RAC1(1), RHO(4), RYR1(72)	16749934	310	83	298	130	86	145	37	3	35	4	0.874	1.000	1.000
332	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(17), CARM1(5), CCND1(15), CREBBP(32), EP300(32), ERCC3(11), ESR1(11), GRIP1(12), GTF2A1(3), GTF2E1(3), GTF2F1(7), HDAC1(5), HDAC2(5), HDAC3(12), HDAC4(14), HDAC5(12), HDAC6(25), MEF2C(11), NCOR2(23), NR0B1(8), NRIP1(17), PELP1(11), POLR2A(21), SRA1(1), TBP(3)	16878927	316	82	302	88	115	94	57	1	48	1	0.0271	1.000	1.000
333	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(6), AASDHPPT(9), AASS(12), ACAT1(6), ACAT2(4), AKR1B10(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), BBOX1(1), DLST(9), DOT1L(8), ECHS1(3), EHHADH(11), EHMT1(23), EHMT2(2), GCDH(6), HADH(1), HADHA(6), HSD17B10(4), HSD17B4(13), HSD3B7(5), NSD1(37), OGDH(13), OGDHL(19), PIPOX(4), PLOD1(4), PLOD2(13), PLOD3(7), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SETD1A(12), SETD7(7), SETDB1(16), SHMT1(5), SHMT2(5), SPCS3(2), SUV39H1(9), SUV39H2(5), TMLHE(6)	20158536	340	82	329	110	117	114	69	9	30	1	0.226	1.000	1.000
334	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(6), BMP4(10), BMP5(14), BMP6(5), BMP7(12), BMP8A(3), BMP8B(1), BTRC(14), CSNK1A1(4), CSNK1A1L(4), CSNK1D(3), CSNK1E(3), CSNK1G1(6), CSNK1G2(2), CSNK1G3(8), DHH(2), FBXW11(5), GLI1(13), GLI2(10), GLI3(28), GSK3B(13), HHIP(13), IHH(3), LRP2(92), PRKACA(6), PRKACB(3), PRKACG(9), PRKX(2), PTCH1(23), PTCH2(12), RAB23(4), SHH(4), SMO(9), STK36(6), SUFU(3), WNT1(1), WNT10A(2), WNT10B(2), WNT11(6), WNT16(7), WNT2(3), WNT2B(8), WNT3(3), WNT3A(1), WNT4(1), WNT5A(7), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2), ZIC2(1)	20670823	419	82	408	143	156	160	57	4	40	2	0.240	1.000	1.000
335	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(40), B3GALT4(3), CDR1(2), DGKI(20), FAU(2), IL6ST(11), MRPL19(6), PIGK(9), RPL10(5), RPL11(3), RPL13(1), RPL13A(1), RPL14(8), RPL15(2), RPL17(6), RPL18(4), RPL18A(2), RPL19(4), RPL21(3), RPL22(31), RPL23(1), RPL24(2), RPL27(1), RPL27A(3), RPL28(3), RPL29(2), RPL3(2), RPL34(1), RPL35A(2), RPL37(3), RPL38(1), RPL39(4), RPL3L(3), RPL4(4), RPL5(7), RPL6(3), RPL7(1), RPL7A(2), RPL8(2), RPL9(2), RPLP0(5), RPS10(1), RPS11(1), RPS12(2), RPS13(1), RPS15(1), RPS16(1), RPS18(3), RPS20(3), RPS21(3), RPS24(2), RPS25(2), RPS27(1), RPS27A(4), RPS28(1), RPS29(2), RPS3(3), RPS3A(1), RPS4X(1), RPS6(7), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), RPS6KA6(19), RPS6KB1(5), RPS6KB2(4), RPS7(5), RPS8(2), RPS9(1), RPSA(1), SLC36A2(6), TBC1D10C(1), TSPAN9(4), UBA52(1), UBB(2), UBC(8)	19078569	350	82	310	109	88	117	67	3	72	3	0.911	1.000	1.000
336	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(4), AGTR2(11), ATP8A1(15), AVPR1A(7), AVPR1B(3), AVPR2(5), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), CCKAR(9), CCKBR(3), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CX3CR1(6), CXCR3(5), CXCR4(1), CXCR6(1), EDNRA(5), EDNRB(4), FPR1(2), FSHR(17), GALR1(3), GALR3(2), GALT(3), GHSR(8), GNB2L1(1), GNRHR(4), GPR77(2), GRPR(4), LHCGR(17), MC1R(3), MC2R(4), MC3R(5), MC4R(5), MC5R(14), NMBR(4), NPY1R(9), NPY2R(5), NPY5R(13), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(13), OXTR(4), PPYR1(8), SSTR1(10), SSTR2(3), SSTR3(3), SSTR4(10), TACR1(7), TACR2(3), TACR3(9), TRHR(3), TSHR(8)	18351949	383	81	371	143	115	168	51	6	43	0	0.157	1.000	1.000
337	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(17), AMY2A(4), AMY2B(11), ENPP1(12), ENPP3(18), G6PC(5), GAA(4), GANAB(10), GBA3(9), GBE1(9), GCK(3), GPI(7), GUSB(5), GYS1(13), GYS2(16), HK1(11), HK2(9), HK3(10), MGAM(51), PGM1(7), PGM3(4), PYGB(11), PYGL(8), PYGM(10), RNPC3(6), SI(65), UCHL1(4), UCHL3(1), UGDH(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2B15(9), UGT2B4(11), UXS1(5)	21023868	413	81	408	107	101	155	96	5	56	0	0.0265	1.000	1.000
338	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(22), ATP4A(9), ATP4B(4), ATP5A1(8), ATP5B(5), ATP5C1(1), ATP5D(1), ATP5E(2), ATP5F1(4), ATP5G1(3), ATP5G2(1), ATP5G3(1), ATP5H(1), ATP5I(2), ATP5J(3), ATP5L(1), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), COX10(3), COX15(3), COX17(1), COX4I1(3), COX5A(1), COX5B(1), COX6A1(3), COX6A2(1), COX6B1(1), COX6C(3), COX7A1(3), COX7B(4), COX7B2(3), COX7C(2), COX8A(1), COX8C(1), CYC1(3), LHPP(2), NDUFA1(1), NDUFA10(7), NDUFA13(1), NDUFA2(3), NDUFA3(4), NDUFA4(1), NDUFA4L2(1), NDUFA5(4), NDUFA6(2), NDUFA8(5), NDUFA9(5), NDUFAB1(2), NDUFB1(1), NDUFB10(1), NDUFB11(3), NDUFB7(3), NDUFB8(1), NDUFC1(1), NDUFC2(1), NDUFS1(13), NDUFS2(7), NDUFS4(3), NDUFS5(1), NDUFS7(2), NDUFS8(3), NDUFV1(3), NDUFV2(2), PPA1(4), PPA2(5), SDHA(15), SDHB(2), SDHC(4), SDHD(3), TCIRG1(6), UQCRB(4), UQCRC1(2), UQCRC2(7), UQCRFS1(3), UQCRH(1), UQCRQ(2)	20433737	373	80	369	103	121	140	54	2	55	1	0.0236	1.000	1.000
339	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(6), AANAT(2), ABP1(5), ACAT1(6), ACAT2(4), ACMSD(8), AFMID(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), AOC2(7), AOC3(10), AOX1(18), ASMT(5), CARM1(5), CAT(4), CYP1A1(12), CYP1A2(11), CYP1B1(2), DDC(9), ECHS1(3), EHHADH(11), GCDH(6), HAAO(2), HADH(1), HADHA(6), HEMK1(3), HSD17B10(4), HSD17B4(13), INMT(2), KMO(11), KYNU(7), LCMT1(2), LCMT2(9), LNX1(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(5), NFX1(15), OGDH(13), OGDHL(19), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), TDO2(3), TPH1(9), TPH2(4), WARS(6), WARS2(3), WBSCR22(5)	21980296	385	80	373	113	112	148	77	6	40	2	0.0538	1.000	1.000
340	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(5), ACADL(8), ACADM(9), ACOX1(7), ACOX2(8), ACOX3(8), ACSL1(14), ACSL3(7), ACSL4(21), ACSL5(9), ACSL6(12), ADIPOQ(2), APOA1(3), APOA2(2), APOA5(2), APOC3(1), AQP7(4), CD36(8), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), CYP27A1(9), CYP4A11(7), CYP4A22(7), CYP7A1(11), CYP8B1(4), DBI(1), EHHADH(11), FABP1(4), FABP2(2), FABP3(1), FABP4(2), FABP5(3), FABP6(3), FABP7(2), FADS2(2), GK(17), GK2(20), HMGCS2(9), ILK(5), LPL(16), ME1(12), MMP1(3), NR1H3(4), OLR1(2), PCK1(9), PCK2(7), PDPK1(3), PLTP(7), PPARA(1), PPARD(3), PPARG(6), RXRA(3), RXRG(8), SCD(6), SCP2(9), SLC27A1(10), SLC27A2(3), SLC27A4(5), SLC27A5(3), SLC27A6(10), SORBS1(18), UBC(8), UCP1(2)	23302521	442	80	433	131	135	167	89	1	50	0	0.0730	1.000	1.000
341	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ABP1(5), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), AOX1(18), CARM1(5), COMT(3), DBH(9), DCT(13), DDC(9), ECH1(2), ESCO1(16), ESCO2(8), FAH(6), GOT1(9), GOT2(3), GSTZ1(5), HEMK1(3), HGD(4), HPD(7), LCMT1(2), LCMT2(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(5), NAT6(1), PNMT(2), PNPLA3(7), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SH3GLB1(7), TAT(7), TH(3), TPO(15), TYR(12), TYRP1(7), WBSCR22(5)	21082149	349	78	338	96	100	129	66	4	50	0	0.0291	1.000	1.000
342	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AGK(10), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), AKR1A1(1), AKR1B1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), CEL(5), DAK(4), DGAT1(3), DGAT2(6), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKI(20), DGKQ(2), DGKZ(10), GK(17), GK2(20), GLA(9), GLB1(6), GPAM(9), LCT(32), LIPA(8), LIPC(8), LIPF(7), LIPG(7), LPL(16), MGLL(2), PNLIP(6), PNLIPRP1(6), PNLIPRP2(9), PNPLA3(7), PPAP2A(6), PPAP2B(3), PPAP2C(1)	21221405	406	77	397	132	126	152	86	3	38	1	0.158	1.000	1.000
343	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1A2(4), EEF1B2(3), EEF1D(8), EEF1G(5), EEF2(13), EEF2K(11), EIF1AX(4), EIF2AK1(8), EIF2AK2(13), EIF2AK3(12), EIF2B2(5), EIF2B3(7), EIF2B4(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF4A1(5), EIF4A2(9), EIF4E(2), EIF4EBP2(1), EIF4G1(15), EIF4G3(24), EIF5(3), EIF5A(5), EIF5B(15), ETF1(7), GSPT2(18), KIAA0664(13), PABPC1(11), PABPC3(9), PAIP1(6), SLC35A4(5)	15890643	267	76	260	65	87	92	43	6	35	4	0.0157	1.000	1.000
344	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(8), AGTR2(11), CALM1(2), CALM2(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CDK5(2), F2(8), FYN(7), GNA11(2), GNAI1(5), GNB1(2), GNGT1(1), GRB2(3), HRAS(1), JAK2(17), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(10), MAPT(9), MYLK(14), PLCG1(12), PRKCA(10), PTK2B(16), RAF1(8), SHC1(7), SOS1(13), STAT1(15), STAT3(10), STAT5A(5), SYT1(4)	15149973	244	74	235	89	87	84	44	1	25	3	0.609	1.000	1.000
345	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(12), ADCY6(14), ADCY8(22), CACNA1A(20), CACNA1B(35), GNAS(24), GNAT3(8), GNB1(2), GNB3(2), GNG13(2), GNG3(2), GRM4(12), ITPR3(21), KCNB1(13), PDE1A(15), PLCB2(8), PRKACA(6), PRKACB(3), PRKACG(9), PRKX(2), SCNN1A(3), SCNN1B(5), SCNN1G(9), TAS1R1(10), TAS1R2(11), TAS1R3(4), TAS2R1(4), TAS2R10(9), TAS2R13(3), TAS2R14(6), TAS2R16(4), TAS2R3(4), TAS2R38(5), TAS2R39(9), TAS2R4(3), TAS2R40(5), TAS2R41(4), TAS2R42(4), TAS2R43(1), TAS2R46(2), TAS2R5(4), TAS2R50(4), TAS2R60(6), TAS2R7(3), TAS2R8(6), TAS2R9(3), TRPM5(9)	20433711	372	74	365	146	125	140	71	2	34	0	0.703	1.000	1.000
346	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(8), CDC42(4), CREB1(6), DAXX(10), DDIT3(2), ELK1(3), GRB2(3), HMGN1(2), HRAS(1), HSPB2(1), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K5(25), MAP3K7(9), MAP3K9(6), MAPK14(4), MAPKAPK2(6), MAPKAPK5(5), MAX(12), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), MKNK1(3), MYC(8), PLA2G4A(13), RAC1(1), RIPK1(9), RPS6KA5(11), SHC1(7), STAT1(15), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TRAF2(3)	13320121	269	74	260	65	75	106	52	1	34	1	0.0296	1.000	1.000
347	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(6), ACTR2(6), ACTR3(1), AKT1(4), ANGPTL2(6), CDC42(4), CFL1(1), CFL2(8), FLNA(40), FLNC(37), FSCN1(5), FSCN3(5), GDI1(4), GDI2(1), LIMK1(8), MYH2(43), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(17), PAK6(4), PAK7(9), PFN1(1), PFN2(2), RHO(4), ROCK1(22), ROCK2(17), RPS4X(1), VASP(3), WASF1(3), WASL(9)	16540338	299	74	296	89	91	126	43	3	34	2	0.0330	1.000	1.000
348	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT1(4), AKT2(6), AKT3(11), ARHGEF11(20), CDC42(4), DLG4(11), GNA13(7), IKBKG(4), LPA(16), MAP2K4(9), MAP3K1(30), MAP3K5(25), MAPK8(10), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), PDK1(2), PHKA2(21), PI3(2), PIK3CB(17), PLD1(14), PLD2(10), PLD3(5), PTK2(12), RDX(16), ROCK1(22), ROCK2(17), SERPINA4(4), SRF(3)	17689412	333	74	321	84	104	108	57	0	61	3	0.0324	1.000	1.000
349	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(3), CDC7(11), CDK2(2), CDT1(3), DIAPH2(31), GMNN(2), MCM10(8), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), NACA(21), PCNA(3), POLA2(3), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), PRIM1(3), RFC1(21), RFC2(4), RFC3(4), RFC4(5), RFC5(8), RPA1(6), RPA2(3), RPA3(3), RPA4(4), RPS27A(4), UBA52(1), UBB(2), UBC(8)	18401804	286	73	265	74	75	135	39	3	32	2	0.0728	1.000	1.000
350	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(22), ATP4B(4), ATP5E(2), ATP5O(1), ATP6AP1(8), ATP6V0A1(7), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(4), ATP6V1G3(2), ATP6V1H(7), ATP7A(29), ATP7B(13), COX10(3), COX4I1(3), COX5A(1), COX5B(1), COX6A1(3), COX6A2(1), COX6B1(1), COX6C(3), COX7A1(3), COX7B(4), COX7C(2), COX8A(1), NDUFA1(1), NDUFA10(7), NDUFA4(1), NDUFA5(4), NDUFA8(5), NDUFB7(3), NDUFS1(13), NDUFS2(7), NDUFV1(3), NDUFV2(2), PPA2(5), SDHA(15), SDHB(2), SHMT1(5), UQCRB(4), UQCRC1(2), UQCRFS1(3), UQCRH(1)	14142139	279	73	275	73	80	112	40	2	44	1	0.0205	1.000	1.000
351	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AGPAT2(2), AGPAT3(4), AGPAT4(5), AKR1A1(1), AKR1B1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), CEL(5), DGAT1(3), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKQ(2), DGKZ(10), GK(17), GLA(9), GLB1(6), LCT(32), LIPC(8), LIPF(7), LIPG(7), LPL(16), PNLIP(6), PNLIPRP1(6), PNLIPRP2(9), PPAP2A(6), PPAP2B(3), PPAP2C(1)	17350704	333	72	329	102	101	121	76	3	32	0	0.0751	1.000	1.000
352	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(29), POLA2(3), POLB(4), POLD1(12), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLG(6), POLG2(3), POLH(12), POLI(7), POLK(11), POLL(7), POLM(8), POLQ(29), PRIM1(3), REV1(13), REV3L(35), RFC5(8)	14833216	258	72	239	60	60	107	48	3	39	1	0.0642	1.000	1.000
353	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(8), DAXX(10), EGF(20), EGFR(12), ETS1(6), ETS2(6), FOS(3), HOXA7(8), HRAS(1), IKBKB(13), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K14(6), MAP3K5(25), MAPK1(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(10), NFKB1(10), NFKBIA(3), PPP2CA(6), PRKCA(10), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), RAF1(8), RELA(6), RIPK1(9), SP1(7), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3)	17531738	314	72	306	94	90	113	58	2	49	2	0.137	1.000	1.000
354	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(18), AR(14), ESR1(11), ESR2(5), ESRRA(2), HNF4A(13), NPM1(3), NR0B1(8), NR1D1(3), NR1D2(2), NR1H2(3), NR1H3(4), NR1I2(3), NR1I3(6), NR2C2(7), NR2E1(8), NR2F1(7), NR2F2(5), NR2F6(4), NR3C1(18), NR4A1(5), NR4A2(11), NR5A1(3), NR5A2(13), PGR(13), PPARA(1), PPARD(3), PPARG(6), RARA(2), RARB(4), RARG(6), ROR1(10), RORA(11), RORC(8), RXRA(3), RXRG(8), THRA(6), THRB(4), VDR(8)	14380270	269	72	258	85	97	97	49	3	22	1	0.156	1.000	1.000
355	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(8), AKT1(4), AKT2(6), AKT3(11), DAG1(6), GNAQ(3), IKBKG(4), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), PDK1(2), PHKA2(21), PIK3CB(17), PITX2(12), PLD1(14), PLD2(10), PLD3(5), VN1R1(5)	16052704	264	72	255	91	85	100	34	1	43	1	0.366	1.000	1.000
356	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(5), ACSS2(8), ACYP1(2), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1A1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH7A1(2), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), G6PC2(11), GALM(1), GAPDH(3), GAPDHS(10), GCK(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), PDHA1(7), PDHA2(10), PDHB(3), PFKL(8), PFKM(9), PFKP(8), PGAM1(3), PGAM2(1), PGAM4(5), PGK1(7), PGK2(6), PGM1(7), PGM3(4), PKLR(7), PKM2(5), TPI1(2)	20778184	325	71	321	112	103	124	59	2	37	0	0.382	1.000	1.000
357	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(5), AKT1(4), BDKRB2(8), CALM1(2), CALM2(4), CAV1(2), CHRM1(6), CHRNA1(7), FLT1(20), FLT4(9), KDR(26), NOS3(11), PDE2A(14), PDE3A(19), PDE3B(15), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKG1(11), PRKG2(11), RYR2(111), SLC7A1(8), SYT1(4), TNNI1(1)	14841596	325	71	317	113	94	123	62	3	39	4	0.431	1.000	1.000
358	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(4), BTK(12), CALM1(2), CALM2(4), CD79A(1), CD79B(2), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP3K1(30), MAPK14(4), MAPK3(3), MAPK8(10), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), RAC1(1), RAF1(8), SHC1(7), SOS1(13), SYK(4), SYT1(4), VAV1(12)	13601950	222	70	213	72	67	80	47	1	26	1	0.458	1.000	1.000
359	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(8), AARS2(7), CARS(9), CARS2(5), DARS(7), DARS2(10), EARS2(5), EPRS(15), FARS2(2), FARSA(6), FARSB(7), GARS(8), HARS(5), HARS2(7), IARS(8), IARS2(20), KARS(5), LARS(19), LARS2(8), MARS(11), MARS2(4), NARS(11), NARS2(10), PARS2(4), QARS(7), RARS(13), RARS2(8), SARS(4), SARS2(6), TARS(9), TARS2(10), VARS(6), VARS2(1), WARS(6), WARS2(3), YARS(5), YARS2(3)	19060344	282	70	277	90	89	112	52	3	26	0	0.612	1.000	1.000
360	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	A4GALT(2), B3GALNT1(6), B3GALT1(12), B3GALT2(8), B3GALT4(3), B3GALT5(4), B3GNT1(5), B3GNT2(1), B3GNT3(5), B3GNT4(4), B3GNT5(6), B4GALNT1(6), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), B4GALT6(6), FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), FUT7(2), FUT9(9), GBGT1(7), GCNT2(11), PIGA(8), PIGB(11), PIGC(3), PIGF(2), PIGG(6), PIGH(5), PIGK(9), PIGL(1), PIGM(1), PIGN(13), PIGO(9), PIGP(3), PIGQ(5), PIGS(1), PIGT(7), PIGU(3), PIGV(7), PIGX(2), PIGZ(5), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3), ST3GAL5(5), ST3GAL6(6), ST6GALNAC3(8), ST6GALNAC4(4), ST6GALNAC5(2), ST6GALNAC6(6), ST8SIA1(2), ST8SIA5(8), UGCG(4)	16968686	310	70	303	75	105	117	52	2	34	0	0.000929	1.000	1.000
361	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRA2A(6), ADRA2C(2), ADRB2(7), ADRB3(3), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), DRD1(7), DRD2(8), DRD3(6), DRD5(11), HRH1(10), HRH2(4), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(17), HTR4(8), HTR5A(12), HTR6(4), HTR7(5)	8984624	232	70	224	82	91	85	42	3	11	0	0.0612	1.000	1.000
362	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(3), BAG4(5), CASP2(6), CASP3(4), CASP8(21), CRADD(3), DFFB(4), FADD(1), JUN(1), LMNA(8), LMNB1(5), LMNB2(4), MADD(17), MAP2K4(9), MAP3K1(30), MAP3K7(9), MAPK8(10), PAK1(3), PAK2(3), PRKDC(54), RB1(26), RIPK1(9), SPTAN1(31), TNFRSF1A(4), TRAF2(3)	14248497	273	70	265	86	77	80	52	4	56	4	0.585	1.000	1.000
363	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(9), ACAA1(5), ACAA2(3), ACADM(9), ACADS(4), ACAT1(6), ACAT2(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH7A1(2), ALDH9A1(2), AOX1(18), AUH(4), BCAT1(7), BCAT2(3), BCKDHA(6), BCKDHB(3), DBT(5), DLD(5), ECHS1(3), EHHADH(11), HADH(1), HADHA(6), HADHB(4), HIBADH(5), HIBCH(6), HMGCL(2), HMGCS1(6), HMGCS2(9), HSD17B10(4), HSD17B4(13), IVD(2), MCCC1(9), MCCC2(5), MCEE(1), MUT(10), OXCT1(10), OXCT2(2), PCCA(6), PCCB(9)	15810646	252	69	248	70	63	101	58	2	28	0	0.109	1.000	1.000
364	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(4), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), CDS1(5), CHAT(5), CHKA(9), CHKB(6), CHPT1(1), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKI(20), DGKQ(2), DGKZ(10), ESCO1(16), ESCO2(8), ETNK1(10), ETNK2(3), GNPAT(11), GPAM(9), GPD1(3), GPD1L(4), GPD2(3), LCAT(4), LYPLA1(1), LYPLA2(7), NAT6(1), PCYT1A(4), PCYT1B(4), PEMT(1), PHOSPHO1(1), PISD(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLD1(14), PLD2(10), PNPLA3(7), PPAP2A(6), PPAP2B(3), PPAP2C(1), PTDSS1(5), PTDSS2(2), SH3GLB1(7)	23545860	348	69	343	126	108	124	69	3	43	1	0.740	1.000	1.000
365	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1C1(6), AKR1C2(3), AKR1C3(2), AKR1C4(6), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), CYP1A1(12), CYP1A2(11), CYP1B1(2), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2F1(4), CYP2S1(8), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(7), DHDH(4), EPHX1(2), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTA5(4), GSTK1(6), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), MGST1(4), MGST3(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5)	20623799	394	69	381	97	104	168	74	4	44	0	0.00276	1.000	1.000
366	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(6), ACTR3(1), ARHGAP1(2), ARHGAP4(11), ARHGAP5(21), ARHGAP6(18), ARHGEF1(12), ARHGEF11(20), ARHGEF5(13), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(5), CFL1(1), DIAPH1(13), GSN(5), LIMK1(8), MYL2(2), MYLK(14), OPHN1(15), PFN1(1), PIP5K1A(8), PIP5K1B(5), PPP1R12B(20), ROCK1(22), SRC(3), TLN1(23), VCL(11)	16688465	274	69	269	93	100	100	48	0	24	2	0.578	1.000	1.000
367	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ABP1(5), ACAT1(6), ACAT2(4), ACMSD(8), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), AOC2(7), AOC3(10), AOX1(18), ASMT(5), CAT(4), CYP19A1(13), CYP1A1(12), CYP1A2(11), CYP2A13(8), CYP2A6(11), CYP2A7(5), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(5), CYP3A4(10), CYP3A5(6), CYP3A7(7), CYP4B1(4), CYP4F8(7), CYP51A1(4), DDC(9), ECHS1(3), EHHADH(11), GCDH(6), HAAO(2), HADHA(6), KMO(11), KYNU(7), MAOA(12), MAOB(7), SDS(1), TDO2(3), TPH1(9), WARS(6), WARS2(3)	20087936	363	69	357	125	99	145	73	4	39	3	0.501	1.000	1.000
368	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(3), CASP10(8), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CFLAR(6), DAXX(10), DFFB(4), FADD(1), FAF1(10), JUN(1), LMNA(8), LMNB1(5), LMNB2(4), MAP2K4(9), MAP3K1(30), MAP3K7(9), MAPK8(10), PAK1(3), PAK2(3), PRKDC(54), PTPN13(30), RB1(26), RIPK2(6), SPTAN1(31)	15656179	307	68	298	84	76	103	58	4	62	4	0.306	1.000	1.000
369	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(33), ACACB(29), ACAT1(6), ACAT2(4), ACOT12(11), ACSS1(5), ACSS2(8), ACYP1(2), AKR1B1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), DLAT(3), DLD(5), GRHPR(3), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), LDHD(2), MDH1(4), MDH2(4), ME1(12), ME2(8), ME3(9), PC(12), PCK1(9), PCK2(7), PDHA1(7), PDHA2(10), PDHB(3), PKLR(7), PKM2(5)	16736435	265	68	256	92	85	97	43	5	34	1	0.548	1.000	1.000
370	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(8), AADAC(6), ABAT(9), ACADS(4), ACAT1(6), ACAT2(4), ACSM1(11), AKR1B10(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH5A1(7), ALDH7A1(2), ALDH9A1(2), BDH1(3), BDH2(4), DDHD1(10), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADH(1), HADHA(6), HMGCL(2), HMGCS1(6), HMGCS2(9), HSD17B10(4), HSD17B4(13), HSD3B7(5), ILVBL(8), L2HGDH(5), OXCT1(10), OXCT2(2), PDHA1(7), PDHA2(10), PDHB(3), PLA1A(6), PPME1(3), PRDX6(4), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	14787189	255	68	245	77	79	91	50	6	28	1	0.134	1.000	1.000
371	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(5), ACTN1(9), ACTN2(16), ACTN3(10), BCAR1(8), BCR(6), CAPN1(5), CAPNS1(2), CAPNS2(3), CAV1(2), CRKL(6), CSK(1), FYN(7), GRB2(3), HRAS(1), ITGA1(17), ITGB1(8), JUN(1), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MAPK8(10), PPP1R12B(20), PTK2(12), PXN(6), RAF1(8), RAP1A(4), ROCK1(22), SHC1(7), SOS1(13), SRC(3), TLN1(23), VCL(11), ZYX(11)	16913420	272	68	264	77	102	87	50	0	32	1	0.0384	1.000	1.000
372	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(8), AGTR1(4), ATF2(8), CALM1(2), CALM2(4), EGFR(12), ELK1(3), GNAQ(3), GRB2(3), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(10), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), PAK1(3), PRKCA(10), PTK2(12), PTK2B(16), RAC1(1), RAF1(8), SHC1(7), SOS1(13), SRC(3), SYT1(4)	12424151	209	67	202	66	60	76	41	0	31	1	0.344	1.000	1.000
373	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), AKR1B10(4), B4GALT1(2), B4GALT2(5), G6PC(5), G6PC2(11), GAA(4), GALE(1), GALK1(1), GALK2(3), GALT(3), GANC(15), GCK(3), GLA(9), GLB1(6), HK1(11), HK2(9), HK3(10), HSD3B7(5), LALBA(2), LCT(32), MGAM(51), PFKL(8), PFKM(9), PFKP(8), PGM1(7), PGM3(4), RDH11(1), RDH12(5), RDH13(4), RDH14(2), UGP2(6)	13671150	247	67	243	91	83	89	47	3	25	0	0.615	1.000	1.000
374	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(6), AKR1D1(8), ARSD(6), ARSE(10), CARM1(5), CYP11B1(8), CYP11B2(9), CYP19A1(13), HEMK1(3), HSD11B1(6), HSD17B1(4), HSD17B12(4), HSD17B2(2), HSD17B3(6), HSD17B7(5), HSD17B8(2), HSD3B1(3), HSD3B2(6), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(5), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SRD5A1(6), STS(8), SULT1E1(9), SULT2A1(7), SULT2B1(4), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), WBSCR22(5)	17574364	356	67	342	98	80	167	58	3	46	2	0.0292	1.000	1.000
375	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(8), CALM1(2), CALM2(4), CRKL(6), GNAQ(3), GRB2(3), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(10), PAK1(3), PLCG1(12), PRKCA(10), PTK2B(16), RAC1(1), RAF1(8), SHC1(7), SOS1(13), SRC(3), SYT1(4)	10198568	177	67	170	58	53	64	35	0	24	1	0.500	1.000	1.000
376	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(56), CDH1(14), CREBBP(32), EP300(32), MAP2K1(2), MAP3K7(9), MAPK3(3), SKIL(7), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6)	9444442	182	67	173	49	48	62	36	2	30	4	0.218	1.000	1.000
377	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1A1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(3), GCK(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHB(3), LDHC(4), PDHA1(7), PDHA2(10), PDHB(3), PFKM(9), PFKP(8), PGAM1(3), PGK1(7), PGM1(7), PGM3(4), PKLR(7), PKM2(5), TPI1(2)	17484356	279	66	277	92	87	103	51	2	36	0	0.252	1.000	1.000
378	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1A1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(3), GCK(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHB(3), LDHC(4), PDHA1(7), PDHA2(10), PDHB(3), PFKM(9), PFKP(8), PGAM1(3), PGK1(7), PGM1(7), PGM3(4), PKLR(7), PKM2(5), TPI1(2)	17484356	279	66	277	92	87	103	51	2	36	0	0.252	1.000	1.000
379	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(2), ALOX12(8), ALOX12B(10), ALOX15(9), ALOX15B(6), ALOX5(10), CBR1(4), CBR3(2), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2J2(5), CYP2U1(2), CYP4A11(7), CYP4A22(7), CYP4F2(12), CYP4F3(8), EPHX2(7), GGT1(5), GPX2(1), GPX3(2), GPX5(6), GPX6(7), GPX7(1), LTA4H(4), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PTGDS(5), PTGES(2), PTGES2(3), PTGIS(7), PTGS1(6), PTGS2(9), TBXAS1(7)	14108848	248	66	240	74	88	90	40	5	25	0	0.0967	1.000	1.000
380	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(9), ACACA(33), ACACB(29), ACADM(9), ACAT1(6), ACAT2(4), ACSS1(5), ACSS2(8), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH7A1(2), ALDH9A1(2), ECHS1(3), EHHADH(11), HADHA(6), HIBCH(6), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), MCEE(1), MLYCD(3), MUT(10), PCCA(6), PCCB(9), SUCLA2(5), SUCLG1(5), SUCLG2(10)	14485204	240	66	234	65	62	88	53	5	31	1	0.0971	1.000	1.000
381	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(4), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPS(8), CDS1(5), CHAT(5), CHKA(9), CHKB(6), CLC(1), CPT1B(6), DGKA(10), DGKB(22), DGKD(18), DGKE(5), DGKG(11), DGKH(11), DGKQ(2), DGKZ(10), ETNK1(10), GNPAT(11), GPD1(3), GPD2(3), LCAT(4), LGALS13(1), LYPLA1(1), LYPLA2(7), PAFAH1B1(2), PAFAH2(2), PCYT1A(4), PCYT1B(4), PEMT(1), PISD(2), PLA2G2E(5), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB2(8), PLCG1(12), PLCG2(29), PPAP2A(6), PPAP2B(3), PPAP2C(1)	17808076	293	65	287	105	93	104	63	3	28	2	0.630	1.000	1.000
382	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(5), ALDOB(9), ALDOC(3), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(3), GAPDHS(10), GCK(3), GOT1(9), GOT2(3), GPI(7), HK1(11), HK2(9), HK3(10), LDHA(8), LDHAL6B(2), LDHB(3), LDHC(4), MDH1(4), MDH2(4), PC(12), PCK1(9), PDHA1(7), PDHA2(10), PDHB(3), PDHX(11), PFKL(8), PFKM(9), PFKP(8), PGAM1(3), PGAM2(1), PGK1(7), PGK2(6), PKLR(7), PKM2(5), TNFAIP1(3), TPI1(2)	15179743	249	65	245	83	87	88	44	2	28	0	0.256	1.000	1.000
383	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(5), ACAA2(3), ACADL(8), ACADM(9), ACADS(4), ACADSB(6), ACADVL(9), ACAT1(6), ACAT2(4), ACOX1(7), ACOX3(8), ACSL1(14), ACSL3(7), ACSL4(21), ACSL5(9), ACSL6(12), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), CYP4A11(7), CYP4A22(7), ECHS1(3), EHHADH(11), GCDH(6), HADH(1), HADHA(6), HADHB(4), HSD17B10(4), HSD17B4(13)	17830726	299	65	293	80	86	108	66	2	37	0	0.0185	1.000	1.000
384	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(4), ALPL(5), ALPP(4), ALPPL2(3), ASCC3(31), ATP13A2(5), DDX18(12), DDX19A(4), DDX23(9), DDX4(15), DDX41(3), DDX47(5), DDX50(10), DDX51(8), DDX52(4), DDX54(8), DDX55(7), DDX56(5), DHFR(5), DHX58(6), ENTPD7(8), EP400(42), ERCC2(1), ERCC3(11), FPGS(5), GCH1(1), GGH(2), IFIH1(5), MOV10L1(19), NUDT5(2), NUDT8(1), PTS(1), RAD54B(14), RAD54L(5), RUVBL2(4), SETX(33), SKIV2L2(17), SMARCA2(24), SMARCA5(19), SPR(1)	22546741	368	65	353	98	127	112	83	4	36	6	0.0284	1.000	1.000
385	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(5), AGMAT(3), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH4A1(4), ALDH9A1(2), AMD1(3), AOC2(7), AOC3(10), ARG1(5), ARG2(3), ASL(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(23), DAO(8), GAMT(3), GATM(5), GLUD1(3), GOT1(9), GOT2(3), MAOA(12), MAOB(7), NOS1(18), NOS3(11), OAT(7), ODC1(2), OTC(7), P4HA1(6), P4HA2(12), P4HA3(3), P4HB(6), PYCR1(3), RARS(13), SMS(8)	15728089	269	64	264	93	89	95	50	6	27	2	0.435	1.000	1.000
386	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(5), AGXT(4), AGXT2(12), ALAS1(8), ALAS2(11), AMT(2), AOC2(7), AOC3(10), ATP6V0C(1), BHMT(2), CBS(11), CHDH(2), CHKA(9), CHKB(6), CPT1B(6), CTH(6), DAO(8), DLD(5), DMGDH(4), GAMT(3), GARS(8), GATM(5), GLDC(16), MAOA(12), MAOB(7), PEMT(1), PISD(2), PLCB2(8), PLCG1(12), PLCG2(29), PSPH(1), SARDH(9), SARS(4), SHMT1(5), SHMT2(5), TARS(9)	15209542	255	64	246	89	78	100	50	0	27	0	0.530	1.000	1.000
387	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(2), C1GALT1(2), C1GALT1C1(6), GALNT1(10), GALNT10(8), GALNT11(12), GALNT12(6), GALNT13(18), GALNT14(6), GALNT2(9), GALNT3(7), GALNT4(8), GALNT5(7), GALNT6(1), GALNT7(13), GALNT8(11), GALNT9(8), GALNTL1(8), GALNTL2(17), GALNTL4(6), GALNTL5(11), GCNT1(5), GCNT3(5), GCNT4(1), OGT(17), ST3GAL1(2), ST3GAL2(6), ST6GALNAC1(4), WBSCR17(16)	11810588	232	64	225	80	62	86	48	1	34	1	0.763	1.000	1.000
388	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(9), ADC(8), ALDH4A1(4), ALDH5A1(7), CAD(25), CPS1(23), EARS2(5), EPRS(15), GAD1(6), GAD2(12), GCLC(8), GCLM(2), GFPT1(9), GFPT2(12), GLS(11), GLS2(7), GLUD1(3), GLUD2(9), GLUL(7), GMPS(14), GNPNAT1(2), GOT1(9), GOT2(3), GPT(2), GPT2(5), GSR(6), GSS(5), NADSYN1(6), NAGK(2), PPAT(9), QARS(7)	14398876	252	63	246	79	81	79	48	4	38	2	0.276	1.000	1.000
389	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(8), AARS2(7), ABAT(9), ACY3(3), ADSL(8), ADSS(6), ADSSL1(5), AGXT(4), AGXT2(12), ASL(2), ASNS(9), ASPA(5), ASS1(2), CAD(25), CRAT(3), DARS(7), DARS2(10), DDO(7), DLAT(3), DLD(5), GAD1(6), GAD2(12), GOT1(9), GOT2(3), GPT(2), GPT2(5), NARS(11), NARS2(10), PC(12), PDHA1(7), PDHA2(10), PDHB(3)	13551574	230	63	224	79	58	95	41	5	31	0	0.536	1.000	1.000
390	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	28	AGA(7), ARSB(5), FUCA1(3), FUCA2(4), GALNS(4), GBA(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), HGSNAT(9), HPSE(6), HPSE2(11), HYAL1(2), HYAL2(4), IDS(8), IDUA(7), LCT(32), MAN2B1(14), MAN2B2(5), MAN2C1(7), MANBA(12), NAGLU(3), NEU2(4), NEU3(3), SPAM1(15)	11933424	193	63	192	78	50	82	36	4	21	0	0.880	1.000	1.000
391	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), ELK1(3), FPR1(2), GNA15(2), GNB1(2), GNGT1(1), HRAS(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(3), NCF2(8), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), NFKB1(10), NFKBIA(3), PAK1(3), PIK3C2G(16), PLCB1(5), PPP3CA(4), PPP3CB(5), PPP3CC(6), RAC1(1), RAF1(8), RELA(6), SYT1(4)	13841989	211	62	205	68	64	73	40	2	31	1	0.393	1.000	1.000
392	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), AKR1B10(4), ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), FPGT(6), FUK(8), GMDS(4), GMPPA(6), GMPPB(2), HK1(11), HK2(9), HK3(10), HSD3B7(5), KHK(2), LHPP(2), MPI(5), MTMR1(16), MTMR2(5), MTMR6(10), PFKFB1(8), PFKFB2(4), PFKFB3(4), PFKFB4(4), PFKL(8), PFKM(9), PFKP(8), PGM2(8), PHPT1(1), PMM2(6), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SORD(5), TPI1(2), TSTA3(4)	13401284	209	62	204	79	78	62	36	3	30	0	0.622	1.000	1.000
393	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(5), AGXT(4), AGXT2(12), AKR1B10(4), ALAS1(8), ALAS2(11), AMT(2), AOC2(7), AOC3(10), BHMT(2), CBS(11), CHDH(2), CHKA(9), CHKB(6), CTH(6), DAO(8), DLD(5), DMGDH(4), GAMT(3), GARS(8), GATM(5), GLDC(16), GNMT(3), HSD3B7(5), MAOA(12), MAOB(7), PEMT(1), PHGDH(5), PIPOX(4), PISD(2), PSAT1(5), PSPH(1), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SARDH(9), SARS(4), SARS2(6), SDS(1), SHMT1(5), SHMT2(5), TARS(9), TARS2(10)	15514922	254	62	247	98	79	102	46	1	26	0	0.783	1.000	1.000
394	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(5), ACY3(3), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH7A1(2), ALDH9A1(2), AMDHD1(13), AOC2(7), AOC3(10), ASPA(5), CARM1(5), CNDP1(4), DDC(9), FTCD(8), HAL(6), HARS(5), HARS2(7), HDC(9), HEMK1(3), HNMT(4), LCMT1(2), LCMT2(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(5), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), PRPS1(3), PRPS2(7), UROC1(9), WBSCR22(5)	13908656	244	62	236	80	71	92	45	4	32	0	0.259	1.000	1.000
395	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(6), ALG10B(6), ALG11(6), ALG12(7), ALG13(24), ALG14(2), ALG2(2), ALG3(1), ALG5(2), ALG6(5), ALG8(10), ALG9(4), B4GALT1(2), B4GALT2(5), B4GALT3(10), DAD1(2), DDOST(3), DHDDS(4), DOLPP1(2), DPAGT1(3), DPM1(2), FUT8(13), GANAB(10), MAN1A1(13), MAN1A2(7), MAN1B1(5), MAN1C1(6), MAN2A1(20), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), MGAT5B(10), RFT1(6), RPN1(3), RPN2(5), ST6GAL1(7), STT3B(5)	15130995	254	62	239	65	82	85	55	1	30	1	0.0303	1.000	1.000
396	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(8), ALOX15(9), ALOX5(10), CBR1(4), CBR3(2), CYP4F2(12), CYP4F3(8), EPX(15), GGT1(5), LPO(6), LTA4H(4), MPO(10), PLA2G2E(5), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PRDX2(4), PRDX5(1), PRDX6(4), PTGDS(5), PTGES2(3), PTGIS(7), PTGS1(6), PTGS2(9), TBXAS1(7), TPO(15)	10064017	191	62	183	60	77	65	28	5	16	0	0.172	1.000	1.000
397	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(4), ATF1(6), CDC42(4), CREB1(6), CREB5(5), DUSP1(2), DUSP10(5), EEF2K(11), EIF4E(2), ELK1(3), IL1R1(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K10(7), MAP3K4(21), MAP3K5(25), MAP3K7(9), MAPK1(2), MAPK11(3), MAPK12(3), MAPK13(4), MAPK14(4), MAPKAPK2(6), MAPKAPK5(5), MKNK1(3), MKNK2(3), MYEF2(6), NFKB1(10), NR2C2(7), SRF(3), TRAF6(7)	11929413	207	61	204	59	70	75	40	1	21	0	0.141	1.000	1.000
398	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(17), BAD(2), BAX(3), BCL2L1(4), BCL2L2(2), BOK(2), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CD40(4), CD40LG(6), CRADD(3), CYCS(2), DAXX(10), DFFB(4), FADD(1), FAS(9), FASLG(7), IKBKE(4), LTA(3), MCL1(1), NFKB1(10), NFKBIA(3), NGFR(3), NR3C1(18), NTRK1(13), PTPN13(30), RIPK1(9), TFG(4), TNFRSF1A(4), TNFRSF1B(2), TRAF1(5), TRAF2(3), TRAF3(5), TRAF6(7)	15655494	266	60	260	78	59	107	51	2	47	0	0.273	1.000	1.000
399	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(2), B4GALT2(5), FBP2(1), G6PC(5), GAA(4), GALE(1), GALK1(1), GALK2(3), GALT(3), GANAB(10), GCK(3), GLA(9), GLB1(6), HK1(11), HK2(9), HK3(10), LALBA(2), LCT(32), MGAM(51), PFKM(9), PFKP(8), PGM1(7), PGM3(4)	11638492	197	60	194	83	64	73	37	2	21	0	0.913	1.000	1.000
400	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ARG1(5), ARG2(3), ASL(2), ASS1(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(23), DAO(8), EPRS(15), GAMT(3), GATM(5), GLUD1(3), GLUD2(9), GOT1(9), GOT2(3), LAP3(10), NOS1(18), NOS3(11), OAT(7), OTC(7), P4HA1(6), P4HA2(12), P4HA3(3), PARS2(4), PRODH(12), PYCR1(3), PYCR2(2), PYCRL(1), RARS(13), RARS2(8)	12782303	219	60	215	79	72	81	39	5	20	2	0.676	1.000	1.000
401	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A1L(3), GTF2B(5), GTF2E1(3), GTF2E2(2), GTF2F1(7), GTF2F2(1), GTF2H1(9), GTF2H3(3), GTF2H4(2), GTF2I(4), GTF2IRD1(7), STON1(1), TAF1(57), TAF10(1), TAF1L(40), TAF2(19), TAF4(10), TAF4B(4), TAF5(8), TAF5L(5), TAF6(9), TAF6L(5), TAF7(4), TAF7L(10), TAF9(4), TAF9B(12), TBPL1(5), TBPL2(5)	12968048	248	60	241	59	83	95	43	3	23	1	0.0409	1.000	1.000
402	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(12), ADRBK2(15), ARRB2(4), CALM1(2), CALM2(4), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CLCA1(15), CLCA2(10), CLCA4(15), CNGA3(13), CNGA4(10), CNGB1(13), GNAL(6), GUCA1A(5), GUCA1B(3), GUCA1C(5), PDC(1), PDE1C(12), PRKACA(6), PRKACB(3), PRKACG(9), PRKG1(11), PRKG2(11), PRKX(2)	11219988	216	60	212	73	67	82	34	2	31	0	0.387	1.000	1.000
403	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(8), CREBBP(32), DUSP1(2), EP300(32), IKBKB(13), IL1B(2), IL8(3), MAP2K3(7), MAP2K6(10), MAP3K14(6), MAP3K7(9), MAPK11(3), MAPK14(4), MYD88(3), NFKB1(10), NFKBIA(3), NR3C1(18), RELA(6), TGFBR1(5), TGFBR2(6), TLR2(16)	10691056	198	60	191	51	57	64	43	2	30	2	0.0916	1.000	1.000
404	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(8), BCR(6), BLNK(4), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8IP3(9), PAPPA(27), RAC1(1), RPS6KA1(1), RPS6KA3(19), SHC1(7), SOS1(13), SYK(4), VAV1(12), VAV2(7), VAV3(14)	11251667	189	60	183	58	52	71	38	1	26	1	0.277	1.000	1.000
405	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), DAG1(6), ITPKA(1), ITPKB(12), ITPR1(36), ITPR2(35), ITPR3(21), NFAT5(16), PDE6A(10), PDE6B(5), PDE6C(13), PDE6D(2), PDE6G(1), PDE6H(1), SLC6A13(9), TF(14)	13059603	204	60	201	71	59	86	25	1	32	1	0.344	1.000	1.000
406	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(9), ABP1(5), ACADL(8), ACADM(9), ACADSB(6), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), AOC2(7), AOC3(10), CNDP1(4), DPYD(20), DPYS(6), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADHA(6), MLYCD(3), SDS(1), SMS(8), UPB1(10)	10447050	194	59	191	71	50	68	49	3	24	0	0.554	1.000	1.000
407	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(14), F11(15), F12(2), F13B(17), F2(8), F5(48), F7(2), F8(45), F9(14), FGA(26), FGB(7), FGG(10), LPA(16), PLAT(6), PLAU(6), PLG(14), SERPINB2(9), SERPINE1(5), SERPINF2(4), VWF(25)	12712243	293	59	276	76	69	136	53	0	35	0	0.0381	1.000	1.000
408	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(17), BID(2), BIRC2(10), BIRC3(5), CASP10(8), CASP3(4), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CFLAR(6), CHUK(8), CYCS(2), DFFB(4), FADD(1), GAS2(7), LMNA(8), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), SPTAN1(31), TNFRSF10A(2), TNFRSF10B(5), TNFRSF25(3), TNFSF10(1), TNFSF12(4), TRAF2(3)	11978937	200	59	194	51	51	80	24	3	42	0	0.0965	1.000	1.000
409	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(2), EGFR(12), ELK1(3), GNAS(24), GNB1(2), GNGT1(1), GRB2(3), HRAS(1), IGF1R(13), ITGB1(8), KLK2(2), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MYC(8), NGFR(3), PDGFRA(24), PPP2CA(6), PTPRR(17), RAF1(8), RPS6KA1(1), RPS6KA5(11), SHC1(7), SOS1(13), SRC(3), STAT3(10)	11799432	200	59	191	50	55	77	43	1	23	1	0.0273	1.000	1.000
410	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(9), ACACA(33), ACADL(8), ACADM(9), ACADSB(6), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH9A1(2), ECHS1(3), EHHADH(11), HADHA(6), LDHA(8), LDHB(3), LDHC(4), MCEE(1), MLYCD(3), MUT(10), PCCA(6), PCCB(9), SDS(1), SUCLA2(5), SUCLG1(5), SUCLG2(10)	12101964	216	59	213	59	49	76	54	4	33	0	0.148	1.000	1.000
411	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(5), ACAA2(3), ACADL(8), ACADM(9), ACADS(4), ACADSB(6), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH6A1(6), ALDH9A1(2), AOX1(18), BCAT1(7), BCKDHA(6), BCKDHB(3), ECHS1(3), EHHADH(11), HADHA(6), HADHB(4), HIBADH(5), HMGCL(2), IVD(2), MCCC1(9), MCCC2(5), MCEE(1), MUT(10), OXCT1(10), PCCA(6), PCCB(9), SDS(1)	13157737	219	59	216	70	54	84	51	2	28	0	0.366	1.000	1.000
412	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(54), BMPR1B(6), CCND2(9), CDK4(3), CDKN1B(7), DAZL(6), DMC1(5), EGR1(6), ESR2(5), FSHR(17), GJA4(1), INHA(1), LHCGR(17), MLH1(7), MSH5(10), NCOR1(23), NR5A1(3), NRIP1(17), PGR(13), PRLR(5), PTGER2(3), SMPD1(11), VDR(8), ZP2(12)	12345156	249	58	239	65	51	99	40	6	49	4	0.167	1.000	1.000
413	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(33), ACAT1(6), ACAT2(4), ACYP1(2), AKR1B1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), DLAT(3), DLD(5), GRHPR(3), LDHA(8), LDHB(3), LDHC(4), LDHD(2), MDH1(4), MDH2(4), ME1(12), ME2(8), ME3(9), PC(12), PCK1(9), PDHA1(7), PDHA2(10), PDHB(3), PKLR(7), PKM2(5)	13180165	214	58	210	69	65	78	38	4	29	0	0.379	1.000	1.000
414	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(7), CDK7(7), ERCC3(11), GTF2B(5), GTF2E1(3), GTF2E2(2), GTF2F2(1), GTF2H1(9), GTF2H4(2), ILK(5), POLR1A(16), POLR1B(16), POLR2A(21), POLR2B(22), POLR2C(5), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLR3B(14), POLR3D(3), POLR3E(5), POLR3H(5), TAF5(8), TAF6(9), TAF7(4), TAF9(4), TBP(3)	12564504	197	58	195	59	73	66	29	3	25	1	0.301	1.000	1.000
415	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(56), ASAH1(7), CAMP(1), CASP3(4), CERK(6), CREB1(6), CREB5(5), CXCL2(2), DAG1(6), EPHB2(12), FOS(3), GNAQ(3), ITPKA(1), ITPKB(12), JUN(1), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(9), MAPK8(10), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(5)	9812900	179	58	175	60	48	68	20	1	38	4	0.433	1.000	1.000
416	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(21), CALM1(2), CALM2(4), CREB1(6), ELK1(3), FOS(3), GNAI1(5), GNAQ(3), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), JUN(1), MAP2K1(2), MAPK3(3), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), RAF1(8), RPS6KA3(19), SYT1(4)	12116635	218	57	209	74	80	66	42	1	28	1	0.372	1.000	1.000
417	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(11), ACO1(17), ACO2(7), CLYBL(9), CS(6), DLD(5), DLST(9), FH(8), IDH1(4), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(10), MDH1(4), MDH2(4), OGDH(13), OGDHL(19), PC(12), PCK1(9), PCK2(7), SDHA(15), SDHB(2), SDHC(4), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(10)	10928355	209	57	204	70	82	63	40	4	20	0	0.229	1.000	1.000
418	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM2(4), CHUK(8), EGR2(6), EGR3(7), GNAQ(3), MAP3K1(30), MYC(8), NFATC1(10), NFATC2(13), NFKB1(10), NFKBIA(3), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RELA(6), SYT1(4), VIP(3), VIPR2(4)	9816248	175	57	170	56	49	66	32	2	24	2	0.311	1.000	1.000
419	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(8), ABAT(9), ADSL(8), ADSS(6), AGXT(4), AGXT2(12), ASL(2), ASNS(9), ASPA(5), CAD(25), CRAT(3), DARS(7), DDO(7), GAD1(6), GAD2(12), GOT1(9), GOT2(3), GPT(2), GPT2(5), NARS(11), PC(12)	9296781	165	56	161	53	44	64	29	4	24	0	0.335	1.000	1.000
420	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(9), ALDH4A1(4), ALDH5A1(7), CAD(25), CPS1(23), EPRS(15), GAD1(6), GAD2(12), GCLC(8), GCLM(2), GFPT1(9), GLS(11), GLS2(7), GLUD1(3), GLUL(7), GMPS(14), GOT1(9), GOT2(3), GPT(2), GPT2(5), GSS(5), NADSYN1(6), PPAT(9), QARS(7)	12092421	208	56	202	63	58	68	44	4	32	2	0.322	1.000	1.000
421	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	35	ARSA(2), ARSD(6), ARSE(10), ASAH1(7), B4GALT6(6), CERK(6), DEGS1(5), DEGS2(4), ENPP7(3), GAL3ST1(7), GALC(8), GBA(4), GLA(9), GLB1(6), LCT(32), NEU2(4), NEU3(3), PPAP2A(6), PPAP2B(3), PPAP2C(1), SGMS1(5), SGMS2(5), SGPP1(2), SGPP2(4), SMPD1(11), SMPD2(7), SMPD3(7), SMPD4(8), SPHK1(2), SPHK2(2), SPTLC1(6), SPTLC2(5), UGCG(4), UGT8(14)	12070767	214	56	209	64	56	98	32	3	25	0	0.0763	1.000	1.000
422	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(8), IFNA1(2), IFNB1(3), IKBKB(13), IL1B(2), IL1R1(5), IL1RAP(8), IL6(5), IRAK1(4), IRAK2(9), IRAK3(10), JUN(1), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAP3K14(6), MAP3K7(9), MAPK14(4), MAPK8(10), MYD88(3), NFKB1(10), NFKBIA(3), RELA(6), TGFB1(2), TGFB2(5), TGFB3(9), TOLLIP(1), TRAF6(7)	10714977	192	56	188	44	42	80	37	1	30	2	0.0440	1.000	1.000
423	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(6), BAD(2), BRAF(10), CREB1(6), CREB5(5), DUSP6(2), DUSP9(1), EEF2K(11), EIF4E(2), GRB2(3), MAP2K1(2), MAP2K2(5), MAP3K8(10), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(3), MOS(6), NFKB1(10), RAP1A(4), RPS6KA1(1), RPS6KA2(14), RPS6KA3(19), SHC1(7), SOS1(13), SOS2(17), TRAF3(5)	10740371	172	56	168	59	51	63	37	1	19	1	0.553	1.000	1.000
424	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(12), DLG4(11), EPHB2(12), F2(8), F2RL1(4), F2RL2(2), JUN(1), MAP2K5(3), MAPK1(2), MAPK7(14), MAPK8(10), MYEF2(6), PLD1(14), PLD2(10), PLD3(5), PTK2(12), RAF1(8), RASAL1(14), SRC(3), TEC(8), VAV1(12)	10013158	171	56	168	61	59	54	29	3	26	0	0.692	1.000	1.000
425	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	25	ABP1(5), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), DDC(9), EPX(15), ESCO1(16), ESCO2(8), GOT1(9), GOT2(3), HPD(7), LPO(6), MAOA(12), MAOB(7), MPO(10), NAT6(1), PNPLA3(7), PRDX6(4), SH3GLB1(7), TAT(7), TPO(15)	12074023	187	55	179	62	59	67	34	3	24	0	0.457	1.000	1.000
426	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(9), ABP1(5), ACADM(9), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), AOC2(7), AOC3(10), CNDP1(4), DPYD(20), DPYS(6), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADHA(6), HIBCH(6), MLYCD(3), SMS(8), SRM(1), UPB1(10)	9640368	167	55	164	56	45	61	40	3	18	0	0.334	1.000	1.000
427	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IL2(2), IL2RA(4), IL2RB(3), IL2RG(13), JAK1(20), JAK3(10), JUN(1), LCK(5), MAP2K1(2), MAPK3(3), MAPK8(10), RAF1(8), SHC1(7), SOS1(13), STAT5A(5), STAT5B(7), SYK(4)	8425585	136	55	130	35	35	56	26	2	17	0	0.0659	1.000	1.000
428	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(6), AASDH(10), AASDHPPT(9), AASS(12), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), ATP6V0C(1), BBOX1(1), DLST(9), DOT1L(8), ECHS1(3), EHHADH(11), EHMT1(23), EHMT2(2), GCDH(6), HADHA(6), PLOD1(4), PLOD2(13), PLOD3(7), SDS(1), SHMT1(5), SHMT2(5), TMLHE(6)	12530482	208	55	203	71	66	71	44	5	21	1	0.312	1.000	1.000
429	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(4), AP2A1(7), AP2M1(8), ARF1(3), BAD(2), BTK(12), EEA1(17), GRASP(4), GSK3A(10), GSK3B(13), LYN(9), PDPK1(3), PFKL(8), PFKM(9), PFKP(8), PLCG1(12), PRKCE(10), PRKCZ(3), RAB5A(2), RAC1(1), RPS6KB1(5), VAV2(7)	8954356	157	55	152	55	62	53	25	0	17	0	0.435	1.000	1.000
430	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(6), CASP2(6), CHUK(8), CRADD(3), IKBKB(13), IKBKG(4), JUN(1), LTA(3), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K14(6), MAP4K2(7), MAPK14(4), MAPK8(10), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TANK(5), TNFRSF1A(4), TRAF2(3)	8545840	167	54	165	42	37	62	34	1	31	2	0.105	1.000	1.000
431	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(5), ALDOB(9), ALDOC(3), DERA(10), FBP1(2), FBP2(1), G6PD(6), GPI(7), H6PD(7), PFKL(8), PFKM(9), PFKP(8), PGD(3), PGLS(2), PGM1(7), PGM3(4), PRPS1(3), PRPS1L1(5), PRPS2(7), RBKS(1), RPE(5), RPIA(9), TALDO1(6), TKT(6), TKTL1(9), TKTL2(16)	8567433	158	53	151	50	64	49	23	1	21	0	0.107	1.000	1.000
432	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA1(5), ACAA2(3), ACAD8(5), ACAD9(8), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1B10(4), AKR1C4(6), AKR1D1(8), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), BAAT(7), CEL(5), CYP27A1(9), CYP7A1(11), HADHB(4), HSD3B7(5), LIPA(8), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SLC27A5(3), SOAT1(9), SOAT2(5), SRD5A1(6)	11346074	194	53	191	63	66	67	35	4	21	1	0.205	1.000	1.000
433	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(4), ALOX15(9), ALOX5(10), CYP1A2(11), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2J2(5), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(7), HSD3B7(5), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	8757420	153	53	148	46	47	58	23	4	21	0	0.226	1.000	1.000
434	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), ALAS1(8), ALAS2(11), BLVRA(1), BLVRB(1), COX10(3), COX15(3), CP(15), CPOX(6), EARS2(5), EPRS(15), FECH(7), FTH1(2), FTMT(7), GUSB(5), HCCS(1), HMBS(8), HMOX1(4), HMOX2(3), MMAB(2), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2A1(11), UGT2A3(5), UGT2B10(18), UGT2B11(18), UGT2B15(9), UGT2B17(7), UGT2B28(21), UGT2B4(11), UGT2B7(5), UROD(3), UROS(3)	15055211	267	53	254	68	72	119	46	2	28	0	0.0465	1.000	1.000
435	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(7), CS(6), DLAT(3), DLD(5), DLST(9), FH(8), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(10), MDH1(4), MDH2(4), OGDH(13), PC(12), PDHA1(7), PDHA2(10), PDHB(3), PDHX(11), PDK1(2), PDK2(5), PDK3(12), PDK4(10), PDP2(4), SDHA(15), SDHB(2), SDHC(4), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(10)	10367375	200	53	197	65	71	69	35	2	23	0	0.294	1.000	1.000
436	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(8), CARS(9), DARS(7), EPRS(15), FARS2(2), GARS(8), HARS(5), IARS(8), KARS(5), LARS(19), LARS2(8), MARS(11), MARS2(4), NARS(11), QARS(7), RARS(13), SARS(4), TARS(9), WARS(6), WARS2(3), YARS(5)	11765558	167	52	164	61	46	72	32	1	16	0	0.892	1.000	1.000
437	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(8), ABAT(9), ACADS(4), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH5A1(7), ALDH9A1(2), ECHS1(3), EHHADH(11), GAD1(6), GAD2(12), HADHA(6), HMGCL(2), L2HGDH(5), OXCT1(10), PDHA1(7), PDHA2(10), PDHB(3), SDHB(2), SDS(1)	9314002	166	52	162	48	49	59	36	3	19	0	0.100	1.000	1.000
438	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(10), AZIN1(8), CBX3(4), CLOCK(9), CRY1(9), CRY2(3), DNAJA1(3), EIF4G2(7), ETV6(6), GFRA1(9), GSTM3(5), GSTP1(2), HERPUD1(2), HSPA8(8), IDI1(3), KLF9(3), MYF6(8), NCKAP1(8), NCOA4(8), NR1D2(2), PER1(10), PER2(13), PIGF(2), PPP1R3C(4), PPP2CB(4), PSMA4(2), SF3A3(8), SUMO3(3), TOB1(4), TUBB3(6), UGP2(6), VAPA(6), ZFR(10)	13167207	195	52	190	59	62	71	38	2	22	0	0.382	1.000	1.000
439	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(5), ACP2(1), ACP5(5), ACPP(5), ACPT(5), ALPI(4), ALPL(5), ALPP(4), ALPPL2(3), CYP19A1(13), CYP1A1(12), CYP1A2(11), CYP2A13(8), CYP2A6(11), CYP2A7(5), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(5), CYP3A4(10), CYP3A5(6), CYP3A7(7), CYP4B1(4), CYP4F8(7), CYP51A1(4), PON1(12)	10550838	197	52	193	74	60	77	37	1	20	2	0.693	1.000	1.000
440	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(5), CHIA(3), CHIT1(6), CMAS(7), CTBS(4), CYB5R1(3), CYB5R3(5), GFPT1(9), GFPT2(12), GNE(10), GNPDA1(2), GNPDA2(10), GNPNAT1(2), HEXA(3), HEXB(5), HK1(11), HK2(9), HK3(10), LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), NAGK(2), NANS(7), NPL(7), PGM3(4), PHPT1(1), RENBP(4), UAP1(6)	10429868	180	52	178	54	56	57	37	1	29	0	0.273	1.000	1.000
441	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(30), APOA1(3), APOA4(3), APOC1(3), APOC3(1), APOE(1), CETP(5), CYP7A1(11), DGAT1(3), HMGCR(12), LCAT(4), LDLR(6), LIPC(8), LPL(16), LRP1(51), SCARB1(7), SOAT1(9)	9737188	173	52	170	47	67	54	36	0	16	0	0.0334	1.000	1.000
442	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(5), ACTN1(9), ACTN2(16), ACTN3(10), CAPN1(5), CAPNS1(2), CAPNS2(3), ITGA1(17), ITGB1(8), ITGB3(11), PTK2(12), PXN(6), RAC1(1), SPTAN1(31), SRC(3), TLN1(23)	10471567	162	52	159	61	67	47	23	1	24	0	0.667	1.000	1.000
443	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(5), CREB1(6), CREBBP(32), EP300(32), NCOA3(10), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RARA(2), RXRA(3)	7436105	117	51	112	32	30	37	24	3	21	2	0.157	1.000	1.000
444	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(20), GABBR1(12), GPRC5A(7), GPRC5B(6), GPRC5C(3), GPRC5D(4), GRM1(29), GRM2(9), GRM3(19), GRM4(12), GRM5(27), GRM7(20), GRM8(19)	7056881	187	51	179	65	61	69	31	3	21	2	0.166	1.000	1.000
445	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(14), ACE2(22), AGT(8), AGTR1(4), AGTR2(11), ANPEP(15), CMA1(2), CPA3(5), CTSA(11), CTSG(3), ENPEP(19), LNPEP(10), MAS1(3), MME(11), NLN(4), REN(4), THOP1(3)	7592031	149	51	144	51	34	62	34	2	16	1	0.528	1.000	1.000
446	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(9), BAIAP2(5), CASP1(8), CASP3(4), CASP7(4), CASP8(21), GAPDH(3), INS(3), INSR(18), ITCH(10), MAGI1(24), MAGI2(28), RERE(18), WWP1(19), WWP2(9)	8511067	183	51	177	56	56	59	36	1	30	1	0.394	1.000	1.000
447	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(16), AP2A1(7), AP2M1(8), BIN1(3), CALM1(2), CALM2(4), DNM1(4), EPN1(9), EPS15(11), NME1(2), PICALM(11), PPP3CA(4), PPP3CB(5), PPP3CC(6), SYNJ1(29), SYNJ2(11), SYT1(4)	8178295	136	51	132	51	47	44	26	0	19	0	0.625	1.000	1.000
448	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3D(6), CD3E(2), CD3G(3), CD4(6), CREBBP(32), CSK(1), GNAS(24), GNB1(2), GNGT1(1), HLA-DRA(1), LCK(5), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTPRC(17), ZAP70(9)	7957941	157	50	151	53	55	54	24	1	21	2	0.364	1.000	1.000
449	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3D(6), CD3E(2), CD3G(3), CD4(6), CREBBP(32), CSK(1), GNAS(24), GNB1(2), GNGT1(1), HLA-DRA(1), LCK(5), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTPRC(17), ZAP70(9)	7957941	157	50	151	53	55	54	24	1	21	2	0.364	1.000	1.000
450	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(5), ACY1(3), ADC(8), AGMAT(3), ALDH18A1(9), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), AMD1(3), AOC2(7), AOC3(10), ARG1(5), ARG2(3), ASL(2), ASS1(2), CPS1(23), GATM(5), MAOA(12), MAOB(7), NAGS(3), ODC1(2), OTC(7), SAT1(5), SAT2(1), SMS(8), SRM(1)	10557702	165	50	162	68	52	60	29	3	19	2	0.858	1.000	1.000
451	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	FAU(2), MRPS7(3), RPL10A(1), RPL10L(8), RPL11(3), RPL13(1), RPL13A(1), RPL14(8), RPL18(4), RPL18A(2), RPL19(4), RPL21(3), RPL22L1(5), RPL23A(5), RPL24(2), RPL27(1), RPL27A(3), RPL28(3), RPL29(2), RPL3(2), RPL34(1), RPL35A(2), RPL36AL(1), RPL37(3), RPL37A(1), RPL38(1), RPL39(4), RPL3L(3), RPL6(3), RPL7(1), RPL8(2), RPL9(2), RPS10(1), RPS11(1), RPS12(2), RPS13(1), RPS15A(1), RPS16(1), RPS18(3), RPS20(3), RPS21(3), RPS24(2), RPS25(2), RPS27(1), RPS28(1), RPS29(2), RPS3(3), RPS3A(1), RPS6(7), RPS7(5), RPS8(2), RPS9(1), RPSA(1)	8167792	131	50	122	39	36	49	27	3	16	0	0.685	1.000	1.000
452	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(5), CAPN1(5), CAPN2(11), CAPNS1(2), CAPNS2(3), CXCR3(5), EGF(20), EGFR(12), HRAS(1), ITGA1(17), ITGB1(8), MAPK1(2), MAPK3(3), MYL2(2), MYLK(14), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTK2(12), PXN(6), TLN1(23)	12110743	178	50	175	55	65	53	35	1	23	1	0.137	1.000	1.000
453	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(17), ACO2(7), CS(6), DLD(5), DLST(9), FH(8), IDH1(4), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(10), MDH1(4), MDH2(4), PC(12), PCK1(9), SDHA(15), SDHB(2), SUCLA2(5), SUCLG1(5), SUCLG2(10)	7507343	143	49	141	50	61	42	24	2	14	0	0.330	1.000	1.000
454	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM2(4), DLG4(11), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), NOS1(18), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10), SYT1(4)	9115431	156	49	153	76	54	51	33	1	16	1	0.969	1.000	1.000
455	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ABP1(5), ALDH1A3(8), ALDH3A1(7), ALDH3B2(7), AOC2(7), AOC3(10), DDC(9), EPX(15), GOT1(9), GOT2(3), HPD(7), LPO(6), MAOA(12), MAOB(7), MPO(10), PRDX2(4), PRDX5(1), PRDX6(4), TAT(7), TPO(15)	7660602	153	49	145	54	50	52	28	3	20	0	0.486	1.000	1.000
456	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(5), BIRC2(10), BIRC3(5), CASP3(4), CASP8(21), CFLAR(6), FADD(1), IKBKG(4), JUN(1), MAP2K4(9), MAP3K3(9), MAP3K7(9), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(2), NR2C2(7), RALBP1(6), RIPK1(9), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3)	9349804	149	49	146	38	38	60	24	0	25	2	0.102	1.000	1.000
457	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(6), AKR1D1(8), ARSB(5), ARSD(6), ARSE(10), CYP11B1(8), CYP11B2(9), HSD11B1(6), HSD17B2(2), HSD17B3(6), HSD17B8(2), HSD3B1(3), HSD3B2(6), SRD5A1(6), STS(8), SULT1E1(9), SULT2A1(7), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2B15(9), UGT2B4(11)	9754557	173	48	167	56	46	82	27	2	16	0	0.311	1.000	1.000
458	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	22	ARSA(2), ARSB(5), ARSD(6), ARSE(10), ASAH1(7), GAL3ST1(7), GALC(8), GBA(4), GLA(9), GLB1(6), LCT(32), NEU2(4), NEU3(3), PPAP2A(6), PPAP2B(3), PPAP2C(1), SMPD1(11), SMPD2(7), SPTLC1(6), SPTLC2(5), UGCG(4)	8264638	146	48	143	47	37	71	24	1	13	0	0.302	1.000	1.000
459	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(6), CARM1(5), CBS(11), CTH(6), GGT1(5), HEMK1(3), LCMT1(2), LCMT2(9), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), METTL2B(4), METTL6(5), PAPSS1(8), PAPSS2(7), PRMT2(4), PRMT3(9), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SCLY(3), SEPHS1(12), SEPHS2(5), WBSCR22(5)	8840900	167	48	162	51	60	65	19	2	21	0	0.128	1.000	1.000
460	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), AGPS(8), CHPT1(1), ENPP2(25), ENPP6(11), PAFAH1B1(2), PAFAH1B2(3), PAFAH2(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLD1(14), PLD2(10), PPAP2A(6), PPAP2B(3), PPAP2C(1)	8426272	148	48	142	43	45	55	20	3	24	1	0.198	1.000	1.000
461	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(16), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(22), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(2), POLR2H(3), POLR2J(2), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(3), POLR3H(5)	8487029	130	48	129	36	45	45	17	2	20	1	0.191	1.000	1.000
462	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(8), FADD(1), IKBKB(13), IKBKG(4), IL1R1(5), IRAK1(4), MAP3K1(30), MAP3K14(6), MAP3K7(9), MYD88(3), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TLR4(17), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF6(7)	8589976	144	48	143	33	31	56	26	1	27	3	0.0731	1.000	1.000
463	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(15), G6PD(6), GCLC(8), GCLM(2), GGT1(5), GPX2(1), GPX3(2), GPX5(6), GPX6(7), GPX7(1), GSR(6), GSS(5), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTA5(4), GSTK1(6), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), IDH1(4), IDH2(5), MGST1(4), MGST3(2), TXNDC12(5)	7340923	133	47	129	42	40	47	31	2	12	1	0.282	1.000	1.000
464	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(5), GALNS(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), HGSNAT(9), HPSE(6), HPSE2(11), HYAL1(2), HYAL2(4), IDS(8), IDUA(7), LCT(32), NAGLU(3), SPAM1(15)	7347340	130	47	130	53	29	56	26	3	16	0	0.881	1.000	1.000
465	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(5), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), CYP2C19(6), CYP2C9(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ECHS1(3), EHHADH(11), ESCO1(16), ESCO2(8), HADHA(6), NAT6(1), PNPLA3(7), SH3GLB1(7), YOD1(3)	11203507	125	47	124	43	38	52	21	2	12	0	0.564	1.000	1.000
466	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA1(5), ACAA2(3), ADH1A(2), ADH1B(5), ADH1C(8), ADH4(4), ADH6(10), ADH7(5), ADHFE1(6), AKR1C4(6), AKR1D1(8), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), BAAT(7), CEL(5), CYP27A1(9), CYP7A1(11), HADHB(4), SOAT2(5), SRD5A1(6)	8301184	159	46	156	48	53	54	32	3	17	0	0.121	1.000	1.000
467	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(12), POLD2(6), POLE(47), POLG(6), POLL(7), POLQ(29)	6044414	111	46	98	30	32	57	15	1	6	0	0.164	1.000	1.000
468	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(8), DUSP1(2), IKBKAP(13), IKBKB(13), IKBKG(4), LTA(3), MAP3K1(30), MAP3K14(6), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(9), TANK(5), TNFAIP3(3), TNFRSF1B(2), TRAF1(5), TRAF2(3), TRAF3(5)	8209617	130	46	129	32	32	52	20	1	23	2	0.0868	1.000	1.000
469	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(9), AGT(8), AGTR2(11), EDN1(4), EDNRA(5), EDNRB(4), EGF(20), EGFR(12), FOS(3), HRAS(1), JUN(1), MYC(8), NFKB1(10), PLCG1(12), PRKCA(10), RELA(6)	7459154	124	45	120	48	31	48	31	2	12	0	0.779	1.000	1.000
470	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), FPGT(6), GCK(3), GMDS(4), GMPPA(6), GMPPB(2), HK1(11), HK2(9), HK3(10), KHK(2), MPI(5), PFKFB1(8), PFKFB3(4), PFKFB4(4), PFKM(9), PFKP(8), PMM2(6), SORD(5), TPI1(2)	8759023	125	45	123	60	50	35	24	0	16	0	0.946	1.000	1.000
471	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(7), FUCA1(3), FUCA2(4), GLB1(6), HEXA(3), HEXB(5), LCT(32), MAN2B1(14), MAN2B2(5), MAN2C1(7), MANBA(12), NEU2(4), NEU3(3)	6888206	105	45	104	41	29	41	22	3	10	0	0.778	1.000	1.000
472	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(9), CA1(6), CA12(1), CA13(4), CA14(4), CA2(2), CA3(5), CA4(1), CA5A(6), CA5B(7), CA6(3), CA7(5), CA8(6), CA9(4), CPS1(23), CTH(6), GLS(11), GLS2(7), GLUD1(3), GLUD2(9), GLUL(7), HAL(6)	7721466	137	45	132	48	41	50	18	2	24	2	0.615	1.000	1.000
473	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(5), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR7(6), CD28(3), CD4(6), CSF2(1), CXCR3(5), CXCR4(1), IFNG(9), IFNGR1(5), IFNGR2(4), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18R1(9), IL2(2), IL4(1), IL4R(6), IL5(2), TGFB1(2), TGFB2(5), TGFB3(9)	7439499	135	45	134	44	38	52	24	1	20	0	0.339	1.000	1.000
474	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), G6PD(6), GPI(7), H6PD(7), PFKM(9), PFKP(8), PGD(3), PGLS(2), PGM1(7), PGM3(4), PRPS1(3), PRPS1L1(5), PRPS2(7), RBKS(1), RPE(5), RPIA(9), TAL1(1), TALDO1(6), TKT(6)	7121683	116	45	112	42	44	38	20	1	13	0	0.392	1.000	1.000
475	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(8), CHUK(8), IFNG(9), IKBKB(13), IL2(2), IL4(1), JUN(1), MAP3K1(30), MAP3K5(25), MAP4K5(7), MAPK14(4), MAPK8(10), NFKB1(10), NFKBIA(3), RELA(6), TNFRSF9(2), TNFSF9(6), TRAF2(3)	7209024	148	44	144	40	40	63	20	1	22	2	0.249	1.000	1.000
476	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(4), CFL1(1), GNAQ(3), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), LIMK1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(2), NOX1(16), PIK3C2G(16), PLCB1(5), PPP1R12B(20), PRKCA(10), PTK2(12), RAF1(8), ROCK2(17)	9254834	157	44	152	49	48	50	34	3	22	0	0.559	1.000	1.000
477	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(9), CALCRL(8), CD97(13), CRHR1(3), CRHR2(2), ELTD1(12), EMR1(22), EMR2(6), GHRHR(2), GIPR(5), GLP1R(5), GLP2R(11), GPR64(11), LPHN1(16), LPHN2(22), LPHN3(22), SCTR(5), VIPR1(3), VIPR2(4)	10055000	186	44	180	70	55	79	27	1	22	2	0.509	1.000	1.000
478	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(6), AMD1(3), BHMT(2), CBS(11), CTH(6), DNMT1(14), DNMT3A(8), DNMT3B(15), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), MTAP(4), MTR(12), SRM(1), TAT(7)	7468924	120	44	117	52	47	40	20	1	12	0	0.868	1.000	1.000
479	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(19), CALM1(2), CALM2(4), CAPN2(11), CAPNS1(2), CAPNS2(3), EP300(32), HDAC1(5), HDAC2(5), MEF2D(7), NFATC1(10), NFATC2(13), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), SYT1(4)	8576701	142	44	137	42	52	32	33	1	24	0	0.233	1.000	1.000
480	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(21), ADRB2(7), GNAS(24), PLCE1(41), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	5147041	120	44	116	34	44	29	29	1	16	1	0.163	1.000	1.000
481	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(17), BIRC2(10), BIRC3(5), CASP10(8), CASP3(4), CASP7(4), CASP8(21), CASP9(3), DFFB(4), GZMB(4), PRF1(8), SCAP(12), SREBF1(2), SREBF2(14)	6378058	116	44	111	37	31	44	17	0	24	0	0.456	1.000	1.000
482	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(12), DYRK1B(4), GLI2(10), GLI3(28), GSK3B(13), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), SHH(4), SMO(9), SUFU(3)	5610085	110	44	107	55	39	39	12	3	15	2	0.903	1.000	1.000
483	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(7), CYB5R3(5), GCK(3), GFPT1(9), GNE(10), GNPDA1(2), GNPDA2(10), HEXA(3), HEXB(5), HK1(11), HK2(9), HK3(10), PGM3(4), RENBP(4), UAP1(6)	6187133	98	43	97	36	35	25	23	1	14	0	0.719	1.000	1.000
484	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ABP1(5), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), AOC2(7), AOC3(10), ASPA(5), CNDP1(4), DDC(9), HAL(6), HARS(5), HDC(9), HNMT(4), MAOA(12), MAOB(7), PRPS1(3), PRPS2(7)	8613975	150	43	144	53	45	50	32	3	20	0	0.482	1.000	1.000
485	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(12), EXT2(6), EXTL1(9), EXTL2(8), EXTL3(10), GLCE(5), HS2ST1(7), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), HS3ST5(9), HS6ST1(4), HS6ST2(12), HS6ST3(3), NDST1(14), NDST2(9), NDST3(14), NDST4(15)	7439901	154	43	151	45	44	60	32	1	16	1	0.179	1.000	1.000
486	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(10), GALNT10(8), GALNT2(9), GALNT3(7), GALNT4(8), GALNT6(1), GALNT7(13), GALNT8(11), GALNT9(8), GCNT1(5), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), WBSCR17(16)	5377050	107	43	105	32	29	40	27	1	10	0	0.357	1.000	1.000
487	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(5), EPHA4(19), EPHB1(26), FYN(7), ITGA1(17), ITGB1(8), L1CAM(20), LYN(9), RAP1B(2), SELP(12)	5796064	125	42	122	38	40	47	22	1	15	0	0.191	1.000	1.000
488	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(3), B4GALNT1(6), GLB1(6), HEXA(3), HEXB(5), LCT(32), SLC33A1(9), ST3GAL1(2), ST3GAL2(6), ST3GAL5(5), ST6GALNAC3(8), ST6GALNAC4(4), ST6GALNAC5(2), ST6GALNAC6(6), ST8SIA1(2), ST8SIA5(8)	5831166	107	42	105	40	31	42	18	2	14	0	0.631	1.000	1.000
489	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(5), ADCY1(21), CAP1(7), CCNB1(8), CDC25C(5), GNAI1(5), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), MAPK1(2), MAPK3(3), MYT1(18), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RPS6KA1(1), SRC(3)	7150582	133	42	129	40	50	41	23	1	17	1	0.136	1.000	1.000
490	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(9), CA1(6), CA12(1), CA14(4), CA2(2), CA3(5), CA4(1), CA5A(6), CA5B(7), CA6(3), CA7(5), CA8(6), CA9(4), CPS1(23), CTH(6), GLS(11), GLS2(7), GLUD1(3), GLUL(7), HAL(6)	6927980	124	42	119	37	35	46	17	2	22	2	0.317	1.000	1.000
491	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(17), ARHGDIB(3), BIRC2(10), BIRC3(5), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(4), CASP8(21), CASP9(3), CYCS(2), DFFB(4), GZMB(4), LMNA(8), LMNB1(5), LMNB2(4), PRF1(8)	6936180	136	41	130	42	36	52	21	1	26	0	0.543	1.000	1.000
492	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(6), CSF1(6), CSF2(1), CSF3(1), HLA-DRA(1), IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL11(2), IL12A(5), IL12B(2), IL15(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL7(1), IL8(3), LTA(3), PDGFA(3), TGFB1(2), TGFB2(5), TGFB3(9)	4650214	81	41	80	28	24	37	11	1	8	0	0.463	1.000	1.000
493	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(6), BHMT(2), CBS(11), CTH(6), DNMT1(14), DNMT3A(8), DNMT3B(15), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), MTR(12)	6295427	105	41	102	43	42	34	16	1	12	0	0.762	1.000	1.000
494	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(21), ARHGEF1(12), GNA12(8), GNA13(7), GNAQ(3), GNB1(2), GNGT1(1), MYL2(2), MYLK(14), PLCB1(5), PPP1R12B(20), PRKCA(10), ROCK1(22)	7598901	127	41	123	50	43	41	27	2	11	3	0.868	1.000	1.000
495	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(3), ARFGAP1(2), ARFGAP3(4), ARFGEF2(28), CLTB(6), COPA(19), GBF1(14), GPLD1(13), KDELR1(3), KDELR3(4)	5936033	96	40	94	29	37	29	21	0	8	1	0.327	1.000	1.000
496	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(5), CR1(22), CR2(24), FCGR2B(3), HLA-DRA(1), ICAM1(2), ITGAL(17), ITGB2(14), PTPRC(17)	5411848	105	40	104	30	34	38	17	2	13	1	0.137	1.000	1.000
497	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(2), CALM2(4), CDKN1A(1), GNAQ(3), NFATC1(10), NFATC2(13), NFATC3(12), NFATC4(7), PLCG1(12), PPP3CA(4), PPP3CB(5), PPP3CC(6), PRKCA(10), SP1(7), SP3(11), SYT1(4)	7204844	111	40	106	44	40	34	23	0	14	0	0.796	1.000	1.000
498	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(12), CSF1R(8), EGF(20), EGFR(12), GRB2(3), MET(17), PDGFRA(24), PRKCA(10), SH3GLB1(7), SH3GLB2(6), SH3KBP1(7), SRC(3)	7155198	129	40	126	44	34	45	32	0	16	2	0.453	1.000	1.000
499	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(5), C1QB(3), C1R(11), C1S(8), C2(3), C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19), MASP1(15), MASP2(7), MBL2(4)	7752035	160	40	153	56	35	77	30	0	16	2	0.627	1.000	1.000
500	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(15), CD2(4), CD33(6), CD5(10), CD7(3), CSF2(1), IFNA1(2), IFNB1(3), IFNG(9), IL10(3), IL12A(5), IL12B(2), IL3(2), IL4(1), IL5(2), ITGAX(14), TLR2(16), TLR4(17), TLR7(17), TLR9(6)	6754142	138	40	136	41	41	58	20	1	16	2	0.0937	1.000	1.000
501	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(15), G6PD(6), GCLC(8), GCLM(2), GGT1(5), GPX2(1), GPX3(2), GPX5(6), GSS(5), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(2), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), IDH1(4), IDH2(5), MGST1(4), MGST3(2), PGD(3)	6581275	107	40	104	34	29	42	26	1	8	1	0.334	1.000	1.000
502	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(18), BST1(1), CD38(6), ENPP1(12), ENPP3(18), NADK(9), NADSYN1(6), NMNAT1(3), NMNAT2(3), NMNAT3(1), NNMT(6), NNT(7), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5C3(8), NT5E(6), NT5M(3), NUDT12(4), QPRT(2)	7699061	130	40	127	37	42	44	38	0	6	0	0.135	1.000	1.000
503	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(7), FUCA1(3), FUCA2(4), GLB1(6), HEXA(3), HEXB(5), LCT(32), MAN2C1(7), MANBA(12), NEU2(4), NEU3(3)	5549271	86	40	85	32	19	33	22	2	10	0	0.788	1.000	1.000
504	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRA(1), BLVRB(1), CP(15), CPOX(6), EPRS(15), FECH(7), GUSB(5), HCCS(1), HMBS(8), HMOX1(4), HMOX2(3), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4), UGT2B15(9), UGT2B4(11), UROD(3), UROS(3)	10003330	141	40	136	44	43	64	20	1	13	0	0.419	1.000	1.000
505	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(11), GTF2A1(3), GTF2B(5), GTF2E1(3), GTF2F1(7), HDAC3(12), NCOA1(19), NCOA2(15), NCOA3(10), NCOR2(23), POLR2A(21), RARA(2), RXRA(3), TBP(3)	8960600	137	40	134	48	54	41	27	1	14	0	0.549	1.000	1.000
506	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM2(4), CCL4(5), CCR5(6), CXCL12(6), CXCR4(1), FOS(3), GNAQ(3), JUN(1), MAPK14(4), MAPK8(10), PLCG1(12), PRKCA(10), PTK2B(16), SYT1(4)	4962945	87	39	84	35	29	31	18	0	9	0	0.759	1.000	1.000
507	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(5), C1QB(3), C1R(11), C1S(8), C2(3), C3(22), C5(18), C6(16), C7(20), C8A(9), C8B(5), C9(19), MASP1(15)	7552563	154	39	146	53	34	70	31	0	17	2	0.600	1.000	1.000
508	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABARAP(1), GABRA1(14), GABRA2(14), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(7), GPHN(18), NSF(3), SRC(3), UBQLN1(6)	4390786	113	39	107	33	32	47	21	0	13	0	0.270	1.000	1.000
509	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(17), ACO2(7), AFMID(6), CS(6), GRHPR(3), HAO1(3), HAO2(11), HYI(2), MDH1(4), MDH2(4), MTHFD1(6), MTHFD1L(15), MTHFD2(4)	4944780	88	39	86	28	40	24	18	0	6	0	0.226	1.000	1.000
510	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(6), ABP1(5), AOC2(7), AOC3(10), CES1(13), DDHD1(10), ESCO1(16), ESCO2(8), LIPA(8), NAT6(1), PLA1A(6), PNPLA3(7), PPME1(3), PRDX6(4), SH3GLB1(7)	9195734	111	39	107	40	27	45	24	0	14	1	0.765	1.000	1.000
511	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(3), BET1L(1), BNIP1(4), GOSR1(3), GOSR2(1), SNAP23(3), SNAP25(9), SNAP29(4), STX10(1), STX11(6), STX12(3), STX16(1), STX17(1), STX18(2), STX19(3), STX2(7), STX3(7), STX4(6), STX5(6), STX6(3), STX7(6), STX8(3), TSNARE1(3), USE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP5(1), VAMP7(4), VTI1A(1), VTI1B(6), YKT6(4)	5962055	109	39	105	32	40	33	21	0	15	0	0.349	1.000	1.000
512	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG5(3), ATG7(5), BECN1(1), GABARAP(1), GABARAPL1(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNG(9), INS(3), PIK3C3(14), PIK3R4(21), PRKAA1(8), PRKAA2(10), ULK1(5), ULK2(12), ULK3(5)	7623927	138	39	137	41	33	65	25	0	15	0	0.497	1.000	1.000
513	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(14), ABCC2(30), ABCG2(16), BCHE(17), CES1(13), CES2(2), CYP3A4(10), CYP3A5(6), UGT1A1(6), UGT1A10(7), UGT1A3(2), UGT1A4(5), UGT1A5(7), UGT1A6(3), UGT1A7(7), UGT1A8(5), UGT1A9(4)	8435358	154	39	150	45	35	66	40	0	11	2	0.171	1.000	1.000
514	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(21), GNAS(24), GNB1(2), GNGT1(1), PPP2CA(6), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAG2(4), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	5373906	113	38	109	36	46	33	16	2	15	1	0.343	1.000	1.000
515	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(20), EGFR(12), MAP2K1(2), MAP3K1(30), MAPK14(4), NCOR2(23), RARA(2), RXRA(3), THRA(6), THRB(4)	6019780	106	38	104	39	30	35	22	1	17	1	0.721	1.000	1.000
516	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(5), GALNS(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), IDS(8), IDUA(7), LCT(32), NAGLU(3)	5119464	83	38	83	34	20	32	18	3	10	0	0.790	1.000	1.000
517	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(33), ACACB(29), FASN(7), MCAT(3), OLAH(7), OXSM(6)	5404313	85	38	82	38	33	25	15	2	8	2	0.838	1.000	1.000
518	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(6), CD2(4), CD3D(6), CD3E(2), CD3G(3), CD4(6), CXCR3(5), IFNG(9), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), JAK2(17), STAT4(7), TYK2(10)	5451266	105	38	104	31	22	48	18	1	13	3	0.355	1.000	1.000
519	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(8), F2R(6), GNAI1(5), GNB1(2), GNGT1(1), HRAS(1), ITGA1(17), ITGB1(8), MAP2K1(2), MAPK1(2), MAPK3(3), PLA2G4A(13), PLCB1(5), PRKCA(10), PTGS1(6), PTK2(12), RAF1(8), SRC(3), SYK(4), TBXAS1(7)	8821295	123	38	122	48	30	44	29	4	16	0	0.830	1.000	1.000
520	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(3), CSNK1D(3), DRD1(7), DRD2(8), GRM1(29), PLCB1(5), PPP1CA(3), PPP1R1B(2), PPP2CA(6), PPP3CA(4), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	5735718	99	37	98	44	31	38	12	4	13	1	0.797	1.000	1.000
521	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(9), CARS2(5), CDO1(4), CTH(6), GOT1(9), GOT2(3), LDHA(8), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(4), MPST(1), SDS(1), SULT1B1(7), SULT1C2(4), SULT1C4(4), SULT4A1(4)	4529700	82	37	79	33	19	32	19	2	10	0	0.890	1.000	1.000
522	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(5), ACP2(1), ACP5(5), ACP6(4), ACPP(5), ACPT(5), ALPI(4), ALPL(5), ALPP(4), ALPPL2(3), CMBL(3), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(7), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), PON1(12), PON2(6), PON3(5)	6438004	110	37	108	32	25	42	27	1	15	0	0.205	1.000	1.000
523	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22RA1(4), IL22RA2(1), JAK1(20), JAK2(17), JAK3(10), STAT1(15), STAT3(10), STAT5A(5), STAT5B(7), TYK2(10)	6607070	103	37	102	42	29	39	18	0	14	3	0.807	1.000	1.000
524	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ATP6V0C(1), CAT(4), EPX(15), LPO(6), MPO(10), PRDX2(4), PRDX5(1), PRDX6(4), SHMT1(5), SHMT2(5), TPO(15)	4251973	70	37	68	28	29	26	8	1	6	0	0.680	1.000	1.000
525	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(5), ICAM1(2), ITGA4(10), ITGAL(17), ITGAM(21), ITGB1(8), ITGB2(14), SELE(5), SELL(5), SELP(12)	5968706	99	37	95	36	28	41	14	1	14	1	0.576	1.000	1.000
526	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM2(4), CAMK1(2), CAMK1G(5), CAMK2A(9), CAMK2B(3), CAMK2D(5), CAMK2G(5), CAMK4(5), ESRRA(2), HDAC5(12), MEF2A(3), MEF2B(1), MEF2C(11), MEF2D(7), PPARA(1), PPP3CA(4), PPP3CB(5), PPP3CC(6), SLC2A4(9), SYT1(4), YWHAH(3)	7515013	108	37	107	39	42	31	20	0	15	0	0.485	1.000	1.000
527	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(9), ARG1(5), ARG2(3), ASL(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(23), GAMT(3), GATM(5), GLUD1(3), NAGS(3), OAT(7), ODC1(2), OTC(7), PYCR1(3), SMS(8)	6217565	94	37	93	37	30	33	17	2	10	2	0.838	1.000	1.000
528	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(5), C1QB(3), C1R(11), C1S(8), C2(3), C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19)	6333689	134	36	128	46	25	62	29	0	16	2	0.663	1.000	1.000
529	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(4), EPX(15), LPO(6), MPO(10), MTHFR(10), PRDX6(4), SHMT1(5), SHMT2(5), TPO(15)	4173957	74	36	71	27	32	24	8	2	8	0	0.542	1.000	1.000
530	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(10), AMT(2), ATIC(7), ATP6V0C(1), DHFR(5), GART(9), MTHFD1(6), MTHFD1L(15), MTHFD2(4), MTHFR(10), MTR(12), SHMT1(5), SHMT2(5)	6599249	91	36	88	32	37	31	14	1	8	0	0.379	1.000	1.000
531	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(11), ESR2(5), ITPKA(1), PDE1A(15), PDE1B(7), PLCB1(5), PLCB2(8), PRL(6), TRH(1), VIP(3)	3949492	62	36	61	29	17	19	16	3	7	0	0.970	1.000	1.000
532	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(5), ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(4), NCKAP1(8), NTRK1(13), PIR(6), PSMA7(2), RAC1(1), WASF1(3), WASF2(3), WASF3(8), WASL(9)	5632560	83	35	83	29	26	39	10	0	8	0	0.592	1.000	1.000
533	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	GATA3(3), IL4(1), IL5(2), MAF(2), MAP2K3(7), MAPK14(4), NFATC1(10), NFATC2(13), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	3863826	69	35	67	30	26	20	13	1	8	1	0.602	1.000	1.000
534	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(10), AMT(2), ATIC(7), DHFR(5), FTCD(8), GART(9), MTHFD1(6), MTHFD1L(15), MTHFD2(4), MTHFR(10), MTR(12), SHMT1(5), SHMT2(5)	6928161	98	35	95	34	38	34	17	1	8	0	0.390	1.000	1.000
535	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(11), ACO1(17), ACO2(7), ACSS1(5), ACSS2(8), FH(8), IDH1(4), IDH2(5), MDH1(4), MDH2(4), SUCLA2(5)	4873171	78	35	76	32	30	24	15	0	9	0	0.733	1.000	1.000
536	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(32), ABCB11(15), ABCB4(28), ABCC1(14), ABCC3(13), GSTP1(2)	5405704	104	35	101	38	21	39	25	0	16	3	0.644	1.000	1.000
537	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(2), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT5(2), DDOST(3), DPAGT1(3), DPM1(2), FUT8(13), MAN1A1(13), MAN1B1(5), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), RPN1(3), RPN2(5), ST6GAL1(7)	6843201	110	35	102	33	39	35	27	1	8	0	0.322	1.000	1.000
538	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(8), ADSS(6), DHFR(5), HPRT1(2), IMPDH1(6), MTHFD2(4), OAZ1(1), POLB(4), POLD1(12), POLG(6), PRPS2(7), RRM1(2), SRM(1)	4466818	64	35	62	26	23	21	13	1	6	0	0.821	1.000	1.000
539	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(15), GBA3(9), LPO(6), MPO(10), PRDX2(4), PRDX5(1), PRDX6(4), TPO(15), TYR(12)	3491995	76	35	74	27	25	29	14	1	7	0	0.567	1.000	1.000
540	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(11), CYP2A13(8), CYP2A6(11), CYP2A7(5), NAT1(7), NAT2(4), XDH(14)	2966743	60	34	56	22	19	30	8	0	3	0	0.505	1.000	1.000
541	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(4), B3GAT2(1), B3GAT3(2), B4GALT7(4), CHPF(5), CHST11(8), CHST12(3), CHST14(3), CHST3(4), CHST7(4), CHSY1(8), DSE(19), UST(3), XYLT1(16), XYLT2(4)	4484184	88	34	87	34	35	28	21	0	4	0	0.620	1.000	1.000
542	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(33), CPT1A(9), LEP(2), LEPR(12), PRKAA1(8), PRKAA2(10), PRKAB1(6), PRKAB2(1), PRKAG1(3), PRKAG2(4)	5343713	88	34	85	26	26	33	14	2	13	0	0.456	1.000	1.000
543	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(15), CKM(3), EIF4E(2), FBL(3), GPT(2), LDHA(8), LDHB(3), LDHC(4), MAPK14(4), NCL(7)	3281547	51	34	51	24	9	20	11	3	7	1	0.958	1.000	1.000
544	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(3), CD3D(6), CD3E(2), CD3G(3), IFNG(9), IL2(2), IL2RA(4), IL4(1), TGFB1(2), TGFB2(5), TGFB3(9), TGFBR1(5), TGFBR2(6), TGFBR3(15), TOB1(4), TOB2(5)	3917492	81	34	81	31	25	35	11	1	9	0	0.761	1.000	1.000
545	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(4), CHAT(5), COMT(3), DBH(9), DDC(9), GAD1(6), GAD2(12), HDC(9), MAOA(12), PAH(2), PNMT(2), SLC18A3(7), TH(3), TPH1(9)	4928980	94	33	92	32	29	28	20	1	14	2	0.333	1.000	1.000
546	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), CHST1(8), CHST2(2), CHST4(4), CHST6(6), FUT8(13), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3)	4140897	85	33	81	39	38	26	14	1	6	0	0.857	1.000	1.000
547	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(15), GBA(4), GBA3(9), LPO(6), MPO(10), PRDX6(4), TPO(15)	3039937	63	33	61	24	22	25	9	1	6	0	0.640	1.000	1.000
548	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(6), CBS(11), CTH(6), GGT1(5), MARS(11), MARS2(4), MAT1A(4), MAT2B(12), PAPSS1(8), PAPSS2(7), SCLY(3), SEPHS1(12)	4419353	89	33	86	32	40	29	11	1	8	0	0.435	1.000	1.000
549	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(6), GRB2(3), HBXIP(1), HRAS(1), PTK2B(16), SHC1(7), SOS1(13), SRC(3)	3131844	50	32	47	16	16	22	10	0	2	0	0.525	1.000	1.000
550	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(2), PSMC2(3), PSMC3(1), PSMD1(12), PSMD11(6), PSMD12(5), PSMD13(1), PSMD2(10), PSMD6(3)	5921391	78	32	74	26	21	24	13	0	20	0	0.663	1.000	1.000
551	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), BLVRB(1), HMOX1(4), IL10(3), IL10RA(4), IL10RB(6), IL6(5), JAK1(20), STAT1(15), STAT3(10), STAT5A(5)	4358319	74	32	73	29	25	21	13	0	15	0	0.690	1.000	1.000
552	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH9A1(2), ECHS1(3), EHHADH(11), HADHA(6), SDS(1)	4375145	71	32	70	30	20	27	16	2	6	0	0.744	1.000	1.000
553	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(5), ICAM1(2), ITGAL(17), ITGAM(21), ITGB2(14), SELE(5), SELL(5)	3941677	69	32	68	32	21	27	9	1	10	1	0.866	1.000	1.000
554	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(24), GNB1(2), GNGT1(1), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(10)	3374899	68	31	65	25	29	18	10	1	9	1	0.646	1.000	1.000
555	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(29), GNA12(8), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAR2A(4), PRKAR2B(3)	3655022	59	31	57	21	15	21	14	0	8	1	0.726	1.000	1.000
556	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(20), JAK2(17), JAK3(10), MAPK1(2), MAPK3(3), STAT3(10), TYK2(10)	4165944	72	31	72	27	16	25	15	0	13	3	0.734	1.000	1.000
557	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(6), GNAQ(3), GNB1(2), GNGT1(1), HTR2C(17), PLCB1(5), TUB(13)	2575796	47	31	45	19	16	12	10	4	5	0	0.760	1.000	1.000
558	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(6), AKR1D1(8), CYP11A1(9), CYP11B1(8), CYP11B2(9), CYP17A1(3), CYP21A2(7), HSD11B1(6), HSD3B1(3), HSD3B2(6)	3205297	65	30	65	25	18	25	10	1	11	0	0.676	1.000	1.000
559	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(4), DHCR7(2), FDFT1(1), FDPS(8), HMGCR(12), HMGCS1(6), IDI1(3), LSS(6), MVD(3), MVK(3), NSDHL(10), PMVK(3), SC5DL(3), SQLE(5)	4725661	69	30	68	30	18	26	18	0	7	0	0.891	1.000	1.000
560	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(11), KHK(2), LCT(32), MPI(5), PGM1(7), PYGL(8), PYGM(10), TPI1(2), TREH(2)	4908197	79	30	79	38	20	32	19	0	8	0	0.941	1.000	1.000
561	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(8), CYP51A1(4), DHCR24(6), DHCR7(2), EBP(2), FDFT1(1), FDPS(8), GGCX(10), GGPS1(2), HMGCR(12), HSD17B7(5), IDI1(3), IDI2(1), LSS(6), MVD(3), MVK(3), NQO1(3), NSDHL(10), PMVK(3), SC5DL(3), SQLE(5), TM7SF2(2), VKORC1(1)	6930322	103	30	102	49	29	46	19	0	9	0	0.978	1.000	1.000
562	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(6), AKR1D1(8), CYP11A1(9), CYP11B1(8), CYP11B2(9), CYP17A1(3), CYP21A2(7), HSD11B1(6), HSD3B1(3), HSD3B2(6)	3205297	65	30	65	25	18	25	10	1	11	0	0.676	1.000	1.000
563	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(11), HK2(9), HK3(10), IMPA1(4), IMPA2(6), ISYNA1(2), PGM1(7), PGM3(4), TGDS(4)	4130241	60	30	60	31	23	17	14	0	6	0	0.927	1.000	1.000
564	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(5), ACOX1(7), ACOX3(8), ELOVL2(8), ELOVL5(2), ELOVL6(4), FADS1(4), FADS2(2), FASN(7), HADHA(6), HSD17B12(4), PECR(6), SCD(6)	4854200	69	30	69	30	26	24	12	0	7	0	0.711	1.000	1.000
565	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGA4(10), ITGAL(17), ITGB1(8), ITGB2(14), SELE(5), SELL(5)	4471919	66	30	64	29	21	24	12	1	8	0	0.833	1.000	1.000
566	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(4), PSMB6(4), PSMB7(2), PSMC3(1), PSMD14(2), RPN1(3), RPN2(5), UBE2A(3), UBE3A(16)	4871346	67	30	65	24	21	15	15	1	15	0	0.732	1.000	1.000
567	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(17), ACO2(7), FH(8), IDH1(4), IDH2(5), MDH1(4), MDH2(4), SDHB(2), SUCLA2(5)	3292258	56	30	55	24	25	15	11	0	5	0	0.751	1.000	1.000
568	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(11), ERBB4(27), NRG2(4), NRG3(17), PRKCA(10), PSEN1(5)	3322589	74	29	73	28	24	24	17	0	8	1	0.767	1.000	1.000
569	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(8), CYSLTR2(5), GPR161(6), GPR171(5), GPR18(3), GPR34(9), GPR39(9), GPR45(3), GPR65(11), GPR68(6), GPR75(8)	3643783	73	29	68	32	28	21	20	0	4	0	0.740	1.000	1.000
570	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(5), FOS(3), HRAS(1), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(3), MYC(8), NFKB1(10), NFKBIA(3), PLCB1(5), PRKCA(10), RAF1(8), RELA(6)	5458669	67	28	66	29	19	21	20	2	5	0	0.863	1.000	1.000
571	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(8), CYP11A1(9), CYP11B2(9), CYP17A1(3), HSD11B1(6), HSD3B1(3), HSD3B2(6)	2498956	44	28	44	19	12	16	8	0	8	0	0.699	1.000	1.000
572	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(11), CS(6), MDH1(4), ME1(12), PC(12), PDHA1(7), SLC25A1(2), SLC25A11(3)	3287841	57	28	56	25	17	26	8	1	5	0	0.812	1.000	1.000
573	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(3), DAB1(6), FYN(7), LRP8(4), RELN(48), VLDLR(4)	5115071	74	28	71	32	11	34	20	1	7	1	0.930	1.000	1.000
574	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(6), LDLR(6), MBTPS1(9), MBTPS2(10), SCAP(12), SREBF1(2), SREBF2(14)	4072172	59	28	58	26	23	20	10	0	6	0	0.752	1.000	1.000
575	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(9), CTH(6), GOT1(9), GOT2(3), LDHA(8), LDHB(3), LDHC(4), MPST(1)	2443982	43	27	42	16	8	19	10	1	5	0	0.813	1.000	1.000
576	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(2), B3GALNT1(6), B3GALT5(4), FUT1(4), FUT2(1), FUT9(9), GBGT1(7), GLA(9), HEXA(3), HEXB(5), NAGA(3), ST3GAL1(2), ST3GAL2(6), ST8SIA1(2)	3755630	63	27	59	25	20	27	10	1	5	0	0.657	1.000	1.000
577	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(7), CS(6), FH(8), IDH2(5), MDH1(4), OGDH(13), SDHA(15), SUCLA2(5)	3504439	63	27	62	24	28	19	13	0	3	0	0.491	1.000	1.000
578	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(14), CD44(5), CSF1(6), FCGR3A(1), IL1B(2), IL6R(7), SELL(5), SPN(1), TGFB1(2), TGFB2(5), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(8), TNFSF8(1)	4738496	63	27	60	29	20	21	13	0	9	0	0.874	1.000	1.000
579	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(11), HK2(9), HK3(10), IMPA1(4), PGM1(7), PGM3(4), TGDS(4)	3696126	52	27	52	26	18	16	13	0	5	0	0.917	1.000	1.000
580	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(1), FDPS(8), HMGCR(12), IDI1(3), LSS(6), MVD(3), MVK(3), NQO1(3), NQO2(5), PMVK(3), SC5DL(3), SQLE(5), VKORC1(1)	3924470	58	26	56	27	16	24	13	0	5	0	0.908	1.000	1.000
581	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(4), CASP7(4), DFFB(4), ENDOG(1), GZMB(4), HMGB1(4), HMGB2(4), TOP2A(14), TOP2B(24)	3857901	63	26	62	20	9	22	16	0	16	0	0.850	1.000	1.000
582	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(2), FUT1(4), FUT2(1), FUT9(9), GBGT1(7), GLA(9), HEXA(3), HEXB(5), NAGA(3), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), ST8SIA1(2)	3538266	56	26	55	23	18	24	11	1	2	0	0.714	1.000	1.000
583	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(12), PRKCA(10), PTK2B(16)	2445611	41	26	40	25	20	11	9	0	1	0	0.986	1.000	1.000
584	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(5), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT5(2), FUT8(13), ST3GAL1(2), ST3GAL2(6), ST3GAL3(10), ST3GAL4(3)	2788833	58	26	54	18	25	17	11	1	4	0	0.416	1.000	1.000
585	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(8), CDC25A(8), CDC25B(3), CDC25C(5), CSK(1), GRB2(3), PRKCA(10), PTPRA(10), SRC(3)	3330501	51	26	50	26	19	10	14	0	8	0	0.962	1.000	1.000
586	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(6), AASDH(10), AASDHPPT(9), AASS(12), KARS(5)	2587026	42	25	39	19	6	19	12	1	4	0	0.954	1.000	1.000
587	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(3), NFKB1(10), NFKBIA(3), PLCB1(5), PRKCA(10), RELA(6)	2991782	37	25	37	22	10	11	9	2	5	0	0.987	1.000	1.000
588	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(6), MMP2(7), MMP9(12), RECK(13), TIMP1(4), TIMP2(2), TIMP3(9), TIMP4(1)	2748434	55	25	54	20	15	24	10	0	6	0	0.516	1.000	1.000
589	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(4), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), XYLT1(16), XYLT2(4)	2130232	43	24	43	16	21	11	8	0	3	0	0.495	1.000	1.000
590	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(4), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), XYLT1(16), XYLT2(4)	2130232	43	24	43	16	21	11	8	0	3	0	0.495	1.000	1.000
591	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(7), CAMP(1), DAG1(6), GNAQ(3), ITPKA(1), ITPKB(12)	2031746	30	24	30	11	10	14	1	0	5	0	0.532	1.000	1.000
592	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(6), ACAT2(4), ACYP1(2), ECHS1(3), EHHADH(11), GCDH(6), HADHA(6), SDHB(2), SDS(1)	2849217	41	23	41	15	7	19	12	0	3	0	0.703	1.000	1.000
593	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(5), ACAA2(3), ACAT1(6), ACAT2(4), ECHS1(3), EHHADH(11), HADHA(6), HADHB(4), SDS(1)	3075552	43	23	43	16	11	15	14	0	3	0	0.665	1.000	1.000
594	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), ALAS1(8), ALAS2(11), CPOX(6), FECH(7), HMBS(8), UROD(3), UROS(3)	2842724	49	23	47	13	20	17	7	0	5	0	0.372	1.000	1.000
595	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(7), ALDH3A2(3), ALDH7A1(2), ALDH9A1(2), MIOX(6), UGDH(2)	3009817	39	23	38	16	18	13	4	2	2	0	0.581	1.000	1.000
596	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(4), EPHX2(7), HSD3B7(5), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	1698250	28	23	28	12	12	9	4	1	2	0	0.695	1.000	1.000
597	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(4), CHAT(5), CHKA(9), PCYT1A(4), PDHA1(7), PDHA2(10), PEMT(1), SLC18A3(7)	2387107	47	22	46	25	11	20	9	1	5	1	0.922	1.000	1.000
598	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(3), CHST11(8), CHST12(3), PAPSS1(8), PAPSS2(7), SULT1A1(4), SULT1A2(1), SULT1E1(9), SULT2A1(7), SULT2B1(4), SUOX(2)	3159305	56	22	52	18	28	20	5	0	3	0	0.412	1.000	1.000
599	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(11), DLL1(7), FURIN(6), NOTCH1(11), PSEN1(5)	2760552	40	22	40	25	16	15	5	0	4	0	0.937	1.000	1.000
600	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(7), AOC3(10), CES1(13), ESD(2)	2112292	37	21	34	15	9	12	12	0	4	0	0.728	1.000	1.000
601	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(6), AASDHPPT(9), AASS(12), KARS(5)	1761211	32	21	29	13	6	17	7	1	1	0	0.890	1.000	1.000
602	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(5), LTB4R(2), P2RY1(3), P2RY2(3), P2RY6(4)	2030439	27	21	27	14	11	7	9	0	0	0	0.830	1.000	1.000
603	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), ST3GAL3(10)	1510570	34	20	34	12	18	11	2	0	3	0	0.326	1.000	1.000
604	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(3), DPM2(2), EGR1(6), HRAS(1), KLK2(2), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NGFR(3), RAF1(8)	2829678	39	20	38	20	19	12	7	0	1	0	0.820	1.000	1.000
605	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), NFS1(5), PHPT1(1), TPK1(3)	2334275	42	20	41	13	10	17	6	0	9	0	0.677	1.000	1.000
606	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(6), PLCD1(5), PRKCA(10), TGM2(10)	1783266	31	20	31	17	15	7	7	0	2	0	0.889	1.000	1.000
607	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(11), CYP2E1(2), NR1I3(6), PTGS1(6), PTGS2(9)	1942207	34	19	33	11	12	11	7	1	3	0	0.540	1.000	1.000
608	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(5), ALPP(4), ALPPL2(3), DHFR(5), FPGS(5), GCH1(1), GGH(2), SPR(1)	2130667	30	19	30	13	11	11	5	0	3	0	0.630	1.000	1.000
609	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(11), GLS2(7), GLUD1(3), GLUD2(9)	1620963	30	19	29	14	9	7	6	0	8	0	0.936	1.000	1.000
610	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(8), CYCS(2), GPD2(3), NDUFA1(1), SDHA(15), SDHB(2), SDHC(4), SDHD(3), UQCRC1(2)	2400407	40	18	40	13	18	13	7	0	2	0	0.529	1.000	1.000
611	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(4), GBA3(9), GGT1(5), SHMT1(5), SHMT2(5)	2046382	28	18	28	12	9	12	3	0	4	0	0.693	1.000	1.000
612	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(3), EHHADH(11), HADHA(6), SDS(1)	1772376	22	17	22	16	3	10	8	0	1	0	0.994	1.000	1.000
613	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(3), PAPSS1(8), PAPSS2(7), SULT1A2(1), SULT1E1(9), SULT2A1(7), SUOX(2)	2256029	37	17	34	11	18	13	3	0	3	0	0.622	1.000	1.000
614	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(10), ALDH1A2(11), BCMO1(3), RDH5(3)	1414742	27	16	27	13	7	11	4	0	5	0	0.869	1.000	1.000
615	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(18), PDXK(4), PNPO(1), PSAT1(5)	1718955	28	15	28	13	7	13	5	0	3	0	0.858	1.000	1.000
616	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(3), CD4(6), CD80(5), HLA-DRA(1), IL10(3), IL2(2), IL4(1)	1330988	21	14	21	11	6	7	3	1	4	0	0.921	1.000	1.000