Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.013 0.157 -9999.0 0.0 -0.706 2.0 2.0 IHH -0.042 0.271 0.378 15.0 -0.579 20.0 35.0 SHH Np/Cholesterol/GAS1 -0.086 0.156 -9999.0 0.0 -0.34 30.0 30.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.085 0.154 0.338 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 -0.058 0.16 -9999.0 0.0 -0.37 21.0 21.0 SMO -0.043 0.177 -9999.0 0.0 -0.392 21.0 21.0 AKT1 -0.009 0.088 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.042 0.175 -9999.0 0.0 -0.387 21.0 21.0 STIL -0.046 0.163 0.264 1.0 -0.478 8.0 9.0 DHH N/PTCH2 -0.009 0.093 0.233 4.0 -0.405 5.0 9.0 DHH N/PTCH1 -0.049 0.136 -9999.0 0.0 -0.36 5.0 5.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.024 0.113 -9999.0 0.0 -0.56 5.0 5.0 PTHLH -0.021 0.176 -9999.0 0.0 -0.588 2.0 2.0 determination of left/right symmetry -0.042 0.175 -9999.0 0.0 -0.387 21.0 21.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.02 0.175 -9999.0 0.0 -0.583 2.0 2.0 IHH N/Hhip -0.06 0.213 0.219 16.0 -0.426 25.0 41.0 DHH N/Hhip -0.044 0.143 0.233 2.0 -0.431 13.0 15.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.042 0.175 -9999.0 0.0 -0.387 21.0 21.0 pancreas development -0.037 0.156 0.344 2.0 -0.559 9.0 11.0 HHAT -0.005 0.051 -9999.0 0.0 -0.56 1.0 1.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.076 0.192 -9999.0 0.0 -0.56 16.0 16.0 somite specification -0.042 0.175 -9999.0 0.0 -0.387 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.068 0.164 -9999.0 0.0 -0.389 16.0 16.0 SHH Np/Cholesterol/PTCH2 -0.037 0.119 0.212 4.0 -0.31 17.0 21.0 SHH Np/Cholesterol/Megalin -0.227 0.186 -9999.0 0.0 -0.35 77.0 77.0 SHH -0.048 0.147 -9999.0 0.0 -0.406 17.0 17.0 catabolic process -0.023 0.144 -9999.0 0.0 -0.323 20.0 20.0 SMO/Vitamin D3 -0.069 0.186 -9999.0 0.0 -0.545 8.0 8.0 SHH Np/Cholesterol/Hhip -0.064 0.155 0.211 2.0 -0.365 22.0 24.0 LRP2 -0.332 0.275 -9999.0 0.0 -0.56 70.0 70.0 receptor-mediated endocytosis -0.202 0.216 -9999.0 0.0 -0.543 26.0 26.0 SHH Np/Cholesterol/BOC -0.044 0.11 -9999.0 0.0 -0.31 17.0 17.0 SHH Np/Cholesterol/CDO -0.057 0.122 -9999.0 0.0 -0.31 22.0 22.0 mesenchymal cell differentiation 0.063 0.154 0.362 22.0 -0.209 2.0 24.0 mol:Vitamin D3 -0.043 0.181 -9999.0 0.0 -0.389 16.0 16.0 IHH N/PTCH2 -0.022 0.168 0.224 19.0 -0.347 20.0 39.0 CDON -0.024 0.113 -9999.0 0.0 -0.56 5.0 5.0 IHH N/PTCH1 -0.008 0.165 -9999.0 0.0 -0.326 20.0 20.0 Megalin/LRPAP1 -0.24 0.199 -9999.0 0.0 -0.405 70.0 70.0 PTCH2 0.012 0.062 0.344 4.0 -9999.0 0.0 4.0 SHH Np/Cholesterol -0.045 0.11 -9999.0 0.0 -0.315 17.0 17.0 PTCH1 -0.023 0.144 -9999.0 0.0 -0.323 20.0 20.0 HHIP -0.037 0.157 0.344 2.0 -0.56 9.0 11.0