Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.002 0.023 -9999.0 0.0 -0.253 1.0 1.0 epithelial cell differentiation -0.002 0.026 -9999.0 0.0 -0.285 1.0 1.0 CYFIP2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.032 0.027 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.047 0.156 -9999.0 0.0 -0.56 10.0 10.0 EPHA2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.002 0.025 -9999.0 0.0 -0.269 1.0 1.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.055 0.123 -9999.0 0.0 -0.458 3.0 3.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.002 0.024 -9999.0 0.0 -0.266 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.007 0.042 -9999.0 0.0 -0.268 3.0 3.0 EGF -0.1 0.214 -9999.0 0.0 -0.56 21.0 21.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.153 0.219 -9999.0 0.0 -0.464 39.0 39.0 cortical microtubule organization -0.002 0.026 -9999.0 0.0 -0.285 1.0 1.0 GO:0000145 0.017 0.025 -9999.0 0.0 -0.254 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.002 0.026 -9999.0 0.0 -0.288 1.0 1.0 MLLT4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.004 0.029 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.003 0.028 -9999.0 0.0 -0.306 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.024 0.025 -9999.0 0.0 -0.25 1.0 1.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.002 0.025 -9999.0 0.0 -0.269 1.0 1.0 ARF6/GTP -0.002 0.026 -9999.0 0.0 -0.28 1.0 1.0 CDH1 -0.005 0.051 -9999.0 0.0 -0.56 1.0 1.0 EGFR/EGFR/EGF/EGF -0.071 0.136 -9999.0 0.0 -0.299 28.0 28.0 RhoA/GDP -0.002 0.024 -9999.0 0.0 -0.267 1.0 1.0 actin cytoskeleton organization 0.021 0.026 -9999.0 0.0 -0.259 1.0 1.0 IGF-1R heterotetramer -0.019 0.101 -9999.0 0.0 -0.559 4.0 4.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.019 0.101 -9999.0 0.0 -0.56 4.0 4.0 IGF1 -0.03 0.137 0.344 1.0 -0.56 7.0 8.0 DIAPH1 -0.0 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.002 0.026 0.285 1.0 -9999.0 0.0 1.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.004 0.029 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.021 0.026 -9999.0 0.0 -0.264 1.0 1.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.022 0.025 -9999.0 0.0 -0.253 1.0 1.0 Ephrin A1/EPHA2 -0.002 0.024 -9999.0 0.0 -0.257 1.0 1.0 SEC6/SEC8 -0.002 0.022 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.007 0.043 -9999.0 0.0 -0.272 3.0 3.0 HGF/MET -0.117 0.142 -9999.0 0.0 -0.27 51.0 51.0 HGF -0.237 0.277 -9999.0 0.0 -0.56 50.0 50.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.002 0.023 -9999.0 0.0 -0.255 1.0 1.0 actin cable formation 0.041 0.023 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.015 0.078 -9999.0 0.0 -0.519 2.0 2.0 KIFC3 -0.002 0.025 -9999.0 0.0 -0.269 1.0 1.0 NCK1 -0.005 0.051 -9999.0 0.0 -0.56 1.0 1.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.002 0.025 -9999.0 0.0 -0.269 1.0 1.0 NCK1/GIT1 -0.003 0.037 -9999.0 0.0 -0.405 1.0 1.0 mol:GDP -0.002 0.026 -9999.0 0.0 -0.285 1.0 1.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.002 0.025 -9999.0 0.0 -0.269 1.0 1.0 PIP5K1C -0.002 0.025 -9999.0 0.0 -0.269 1.0 1.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.003 0.026 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.023 0.079 -9999.0 0.0 -0.779 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.025 0.087 -9999.0 0.0 -0.285 11.0 11.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.009 0.072 -9999.0 0.0 -0.56 2.0 2.0 PLEKHA7 -0.007 0.056 -9999.0 0.0 -0.411 2.0 2.0 mol:GTP -0.003 0.028 -9999.0 0.0 -0.304 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.002 0.021 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.002 0.023 -9999.0 0.0 -0.253 1.0 1.0 regulation of cell-cell adhesion 0.021 0.026 -9999.0 0.0 -0.259 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.002 0.023 -9999.0 0.0 -0.255 1.0 1.0