Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.001 0.045 -9999.0 0.0 -0.243 1.0 1.0 epithelial cell differentiation 0.042 0.036 -9999.0 0.0 -0.281 1.0 1.0 CYFIP2 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.017 0.06 0.266 1.0 -9999.0 0.0 1.0 EGFR -0.022 0.149 -9999.0 0.0 -0.512 10.0 10.0 EPHA2 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.024 0.025 -9999.0 0.0 -0.274 1.0 1.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.048 0.011 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.041 0.119 -9999.0 0.0 -0.405 3.0 3.0 CTNND1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.023 0.025 -9999.0 0.0 -0.27 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.034 -9999.0 0.0 -0.272 2.0 2.0 EGF -0.064 0.191 -9999.0 0.0 -0.512 18.0 18.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.166 0.213 -9999.0 0.0 -0.464 37.0 37.0 cortical microtubule organization 0.042 0.036 -9999.0 0.0 -0.281 1.0 1.0 GO:0000145 -0.022 0.023 -9999.0 0.0 -0.258 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.047 0.038 -9999.0 0.0 -0.283 1.0 1.0 MLLT4 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.032 0.035 -9999.0 0.0 -0.261 2.0 2.0 ARF6 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.043 -9999.0 0.0 -0.301 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.012 0.023 -9999.0 0.0 -0.252 1.0 1.0 PVRL2 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.024 0.025 -9999.0 0.0 -0.274 1.0 1.0 ARF6/GTP 0.047 0.045 -9999.0 0.0 -0.285 1.0 1.0 CDH1 0.017 0.05 -9999.0 0.0 -0.512 1.0 1.0 EGFR/EGFR/EGF/EGF -0.039 0.147 -9999.0 0.0 -0.311 24.0 24.0 RhoA/GDP 0.041 0.038 -9999.0 0.0 -0.272 1.0 1.0 actin cytoskeleton organization -0.025 0.025 -9999.0 0.0 -0.271 1.0 1.0 IGF-1R heterotetramer 0.006 0.097 -9999.0 0.0 -0.511 4.0 4.0 GIT1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.006 0.097 -9999.0 0.0 -0.512 4.0 4.0 IGF1 -0.004 0.132 0.381 1.0 -0.512 7.0 8.0 DIAPH1 0.044 0.06 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.042 0.036 0.281 1.0 -9999.0 0.0 1.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.032 0.035 -9999.0 0.0 -0.261 2.0 2.0 CTNNA1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.025 0.025 -9999.0 0.0 -0.277 1.0 1.0 EFNA1 0.021 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.025 0.025 -9999.0 0.0 -0.267 1.0 1.0 Ephrin A1/EPHA2 0.029 0.038 -9999.0 0.0 -0.271 1.0 1.0 SEC6/SEC8 -0.029 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.025 0.035 -9999.0 0.0 -0.276 2.0 2.0 HGF/MET -0.095 0.163 -9999.0 0.0 -0.277 50.0 50.0 HGF -0.199 0.264 -9999.0 0.0 -0.512 49.0 49.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.001 0.045 -9999.0 0.0 -0.245 1.0 1.0 actin cable formation 0.037 0.1 0.326 6.0 -9999.0 0.0 6.0 KIAA1543 -0.027 0.049 -9999.0 0.0 -0.378 2.0 2.0 KIFC3 -0.024 0.025 -9999.0 0.0 -0.274 1.0 1.0 NCK1 0.019 0.049 -9999.0 0.0 -0.512 1.0 1.0 EXOC3 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.024 0.025 -9999.0 0.0 -0.274 1.0 1.0 NCK1/GIT1 0.03 0.039 -9999.0 0.0 -0.377 1.0 1.0 mol:GDP 0.042 0.036 -9999.0 0.0 -0.281 1.0 1.0 EXOC4 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.024 0.024 -9999.0 0.0 -0.274 1.0 1.0 PIP5K1C -0.024 0.025 -9999.0 0.0 -0.274 1.0 1.0 LIMA1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.001 0.085 0.282 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.068 0.154 -9999.0 0.0 -0.581 8.0 8.0 IGF-1R heterotetramer/IGF1 0.007 0.102 -9999.0 0.0 -0.293 11.0 11.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.015 0.069 -9999.0 0.0 -0.512 2.0 2.0 PLEKHA7 -0.028 0.052 -9999.0 0.0 -0.396 2.0 2.0 mol:GTP 0.041 0.042 -9999.0 0.0 -0.299 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.006 0.072 0.305 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.001 0.045 -9999.0 0.0 -0.243 1.0 1.0 regulation of cell-cell adhesion -0.025 0.025 -9999.0 0.0 -0.271 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.001 0.045 -9999.0 0.0 -0.245 1.0 1.0