Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.037 0.082 -9999.0 0.0 -0.508 1.0 1.0 IHH -0.052 0.069 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.329 0.195 -9999.0 0.0 -0.42 43.0 43.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.327 0.193 0.417 43.0 -9999.0 0.0 43.0 SMO/beta Arrestin2 0.045 0.056 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.039 0.059 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.037 0.059 -9999.0 0.0 -0.336 1.0 1.0 ARRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.05 0.206 -9999.0 0.0 -0.694 5.0 5.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.039 0.058 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.007 0.093 -9999.0 0.0 -0.374 1.0 1.0 DHH N/PTCH2 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.035 0.043 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.002 0.096 -9999.0 0.0 -0.694 1.0 1.0 DHH 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.033 0.146 -9999.0 0.0 -1.009 1.0 1.0 determination of left/right symmetry 0.039 0.058 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.002 0.096 -9999.0 0.0 -0.694 1.0 1.0 skeletal system development 0.033 0.144 -9999.0 0.0 -0.994 1.0 1.0 IHH N/Hhip -0.046 0.068 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.009 0.048 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.039 0.058 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development -0.035 0.074 -9999.0 0.0 -9999.0 0.0 0.0 HHAT -0.024 0.163 -9999.0 0.0 -0.694 3.0 3.0 PI3K 0.005 0.13 -9999.0 0.0 -0.943 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.537 0.295 -9999.0 0.0 -0.694 42.0 42.0 somite specification 0.039 0.058 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.018 0.099 -9999.0 0.0 -0.359 3.0 3.0 SHH Np/Cholesterol/PTCH2 0.004 0.098 -9999.0 0.0 -0.401 3.0 3.0 SHH Np/Cholesterol/Megalin -0.075 0.184 -9999.0 0.0 -0.402 13.0 13.0 SHH -0.004 0.124 -9999.0 0.0 -0.517 3.0 3.0 catabolic process 0.029 0.049 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 0.036 0.104 -9999.0 0.0 -0.41 1.0 1.0 SHH Np/Cholesterol/Hhip -0.019 0.099 -9999.0 0.0 -0.401 3.0 3.0 LRP2 -0.116 0.276 -9999.0 0.0 -0.694 10.0 10.0 receptor-mediated endocytosis -0.022 0.153 -9999.0 0.0 -0.467 2.0 2.0 SHH Np/Cholesterol/BOC -0.036 0.153 -9999.0 0.0 -0.402 8.0 8.0 SHH Np/Cholesterol/CDO 0.004 0.098 -9999.0 0.0 -0.401 3.0 3.0 mesenchymal cell differentiation 0.019 0.098 0.398 3.0 -9999.0 0.0 3.0 mol:Vitamin D3 0.031 0.101 -9999.0 0.0 -0.357 3.0 3.0 IHH N/PTCH2 -0.009 0.034 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.052 0.052 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 -0.077 0.21 -9999.0 0.0 -0.517 10.0 10.0 PTCH2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.006 0.098 -9999.0 0.0 -0.41 3.0 3.0 PTCH1 0.029 0.049 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.035 0.074 -9999.0 0.0 -9999.0 0.0 0.0