Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.05 0.071 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.077 0.037 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.222 0.149 -9999.0 0.0 -0.321 34.0 34.0 LRPAP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.22 0.148 0.319 34.0 -9999.0 0.0 34.0 SMO/beta Arrestin2 0.073 0.051 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.048 0.046 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.055 0.054 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.029 0.164 -9999.0 0.0 -0.535 5.0 5.0 ADRBK1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.061 0.051 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.071 0.11 0.294 2.0 -9999.0 0.0 2.0 DHH N/PTCH2 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.07 0.039 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.012 0.076 -9999.0 0.0 -0.535 1.0 1.0 DHH 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.043 0.126 -9999.0 0.0 -0.806 1.0 1.0 determination of left/right symmetry 0.061 0.051 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.014 0.076 -9999.0 0.0 -0.535 1.0 1.0 skeletal system development 0.043 0.124 -9999.0 0.0 -0.797 1.0 1.0 IHH N/Hhip 0.091 0.048 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.059 0.034 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.061 0.051 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development 0.056 0.046 -9999.0 0.0 -9999.0 0.0 0.0 HHAT -0.011 0.129 -9999.0 0.0 -0.535 3.0 3.0 PI3K 0.02 0.101 -9999.0 0.0 -0.705 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.42 0.226 -9999.0 0.0 -0.535 42.0 42.0 somite specification 0.061 0.051 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.028 0.075 -9999.0 0.0 -0.264 2.0 2.0 SHH Np/Cholesterol/PTCH2 0.001 0.076 -9999.0 0.0 -0.305 3.0 3.0 SHH Np/Cholesterol/Megalin -0.048 0.127 -9999.0 0.0 -0.303 10.0 10.0 SHH -0.013 0.093 -9999.0 0.0 -0.392 3.0 3.0 catabolic process 0.065 0.042 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 0.07 0.09 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip 0.02 0.087 -9999.0 0.0 -0.305 3.0 3.0 LRP2 -0.081 0.219 -9999.0 0.0 -0.535 10.0 10.0 receptor-mediated endocytosis 0.016 0.118 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC -0.026 0.111 -9999.0 0.0 -0.305 7.0 7.0 SHH Np/Cholesterol/CDO 0.001 0.076 -9999.0 0.0 -0.305 3.0 3.0 mesenchymal cell differentiation -0.02 0.086 0.303 3.0 -9999.0 0.0 3.0 mol:Vitamin D3 0.068 0.104 -9999.0 0.0 -0.263 2.0 2.0 IHH N/PTCH2 0.067 0.027 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.072 0.042 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 -0.045 0.167 -9999.0 0.0 -0.391 10.0 10.0 PTCH2 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.006 0.073 -9999.0 0.0 -0.303 3.0 3.0 PTCH1 0.065 0.042 -9999.0 0.0 -9999.0 0.0 0.0 HHIP 0.056 0.046 -9999.0 0.0 -9999.0 0.0 0.0