Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.013 0.076 -9999.0 0.0 -0.205 7.0 7.0 epithelial cell differentiation 0.012 0.088 -9999.0 0.0 -0.211 7.0 7.0 CYFIP2 0.018 0.058 -9999.0 0.0 -0.41 1.0 1.0 ENAH 0.007 0.095 0.267 3.0 -9999.0 0.0 3.0 EGFR 0.012 0.063 -9999.0 0.0 -0.41 1.0 1.0 EPHA2 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.04 0.078 0.173 1.0 -0.205 9.0 10.0 CTNNB1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.044 0.042 -9999.0 0.0 -0.248 1.0 1.0 AQP5 -0.062 0.159 -9999.0 0.0 -0.446 7.0 7.0 CTNND1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.033 0.07 0.172 1.0 -0.202 7.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.037 0.073 0.172 1.0 -0.202 8.0 9.0 EGF 0.005 0.085 -9999.0 0.0 -0.264 4.0 4.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.02 0.094 -9999.0 0.0 -0.591 1.0 1.0 cortical microtubule organization 0.012 0.088 -9999.0 0.0 -0.211 7.0 7.0 GO:0000145 -0.032 0.066 0.159 1.0 -0.193 7.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.016 0.091 -9999.0 0.0 -0.213 7.0 7.0 MLLT4 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.033 0.052 -9999.0 0.0 -0.192 5.0 5.0 ARF6 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.05 0.029 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.023 0.066 0.168 1.0 -9999.0 0.0 1.0 PVRL2 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.033 0.071 0.173 1.0 -0.205 7.0 8.0 ARF6/GTP 0.054 0.033 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.031 0.145 -9999.0 0.0 -0.41 7.0 7.0 EGFR/EGFR/EGF/EGF -0.003 0.103 -9999.0 0.0 -0.222 9.0 9.0 RhoA/GDP 0.014 0.088 -9999.0 0.0 -0.207 7.0 7.0 actin cytoskeleton organization -0.041 0.075 0.161 1.0 -0.201 9.0 10.0 IGF-1R heterotetramer -0.006 0.113 -9999.0 0.0 -0.409 4.0 4.0 GIT1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.006 0.113 -9999.0 0.0 -0.41 4.0 4.0 IGF1 -0.022 0.117 -9999.0 0.0 -0.41 4.0 4.0 DIAPH1 0.022 0.129 -9999.0 0.0 -0.62 1.0 1.0 Wnt receptor signaling pathway -0.012 0.088 0.211 7.0 -9999.0 0.0 7.0 RHOA 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.033 0.054 -9999.0 0.0 -0.199 5.0 5.0 CTNNA1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.042 0.076 0.162 1.0 -0.205 9.0 10.0 EFNA1 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.034 0.068 0.164 1.0 -0.199 7.0 8.0 Ephrin A1/EPHA2 0.011 0.072 -9999.0 0.0 -0.201 5.0 5.0 SEC6/SEC8 -0.037 0.057 -9999.0 0.0 -0.196 6.0 6.0 MGAT3 -0.037 0.074 0.173 1.0 -0.205 8.0 9.0 HGF/MET -0.034 0.132 -9999.0 0.0 -0.237 15.0 15.0 HGF -0.064 0.153 -9999.0 0.0 -0.247 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.013 0.077 -9999.0 0.0 -0.207 7.0 7.0 actin cable formation 0.03 0.103 0.295 4.0 -9999.0 0.0 4.0 KIAA1543 -0.053 0.108 0.161 1.0 -0.278 9.0 10.0 KIFC3 -0.033 0.07 0.173 1.0 -0.205 7.0 8.0 NCK1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.034 0.071 0.173 1.0 -0.205 7.0 8.0 NCK1/GIT1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.012 0.088 -9999.0 0.0 -0.211 7.0 7.0 EXOC4 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.036 0.066 -9999.0 0.0 -0.205 7.0 7.0 PIP5K1C -0.033 0.071 0.173 1.0 -0.205 7.0 8.0 LIMA1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.008 0.105 0.288 3.0 -9999.0 0.0 3.0 adherens junction assembly -0.082 0.17 -9999.0 0.0 -0.47 7.0 7.0 IGF-1R heterotetramer/IGF1 -0.023 0.132 -9999.0 0.0 -0.252 12.0 12.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.002 0.099 -9999.0 0.0 -0.41 3.0 3.0 PLEKHA7 -0.054 0.114 0.173 1.0 -0.291 9.0 10.0 mol:GTP 0.048 0.028 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.023 0.077 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.013 0.076 -9999.0 0.0 -0.205 7.0 7.0 regulation of cell-cell adhesion -0.041 0.075 0.161 1.0 -0.201 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.013 0.077 -9999.0 0.0 -0.207 7.0 7.0