Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events regulated by Ret tyrosine kinase	10.0	822.0	82.0	-0.132	0.026	1000.0	-1000.0	-0.047	-1000.0
FOXA2 and FOXA3 transcription factor networks	7.0	361.0	46.0	-0.498	0.032	1000.0	-1000.0	-0.078	-1000.0
Endothelins	6.0	631.0	96.0	-0.136	0.026	1000.0	-1000.0	-0.044	-1000.0
HIF-1-alpha transcription factor network	5.0	403.0	76.0	-0.208	0.03	1000.0	-1000.0	-0.079	-1000.0
IL4-mediated signaling events	5.0	504.0	91.0	-0.532	0.404	1000.0	-1000.0	-0.099	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	224.0	44.0	-0.067	0.025	1000.0	-1000.0	-0.023	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	351.0	68.0	-0.178	0.13	1000.0	-1000.0	-0.074	-1000.0
IL23-mediated signaling events	5.0	325.0	60.0	-0.274	0.04	1000.0	-1000.0	-0.076	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	143.0	34.0	-0.024	0.033	1000.0	-1000.0	-0.022	-1000.0
Syndecan-1-mediated signaling events	4.0	145.0	34.0	-0.088	0.024	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by the Hedgehog family	4.0	242.0	52.0	-0.068	0.029	1000.0	-1000.0	-0.034	-1000.0
p75(NTR)-mediated signaling	4.0	603.0	125.0	-0.081	0.058	1000.0	-1000.0	-0.062	-1000.0
Glucocorticoid receptor regulatory network	4.0	542.0	114.0	-0.35	0.191	1000.0	-1000.0	-0.044	-1000.0
Reelin signaling pathway	4.0	272.0	56.0	-0.071	0.051	1000.0	-1000.0	-0.03	-1000.0
TCR signaling in naïve CD8+ T cells	4.0	382.0	93.0	-0.084	0.037	1000.0	-1000.0	-0.054	-1000.0
IL6-mediated signaling events	4.0	333.0	75.0	-0.151	0.028	1000.0	-1000.0	-0.057	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	342.0	74.0	-0.082	0.054	1000.0	-1000.0	-0.052	-1000.0
TCGA08_retinoblastoma	4.0	37.0	8.0	-0.015	0.022	1000.0	-1000.0	-0.002	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	365.0	88.0	-0.121	0.036	1000.0	-1000.0	-0.059	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	510.0	120.0	-0.134	0.108	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling events	4.0	22.0	5.0	-0.031	0.024	1000.0	-1000.0	0.004	-1000.0
ErbB2/ErbB3 signaling events	3.0	232.0	65.0	-0.147	0.034	1000.0	-1000.0	-0.059	-1000.0
IL12-mediated signaling events	3.0	322.0	87.0	-0.133	0.046	1000.0	-1000.0	-0.067	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	164.0	54.0	-0.082	0.039	1000.0	-1000.0	-0.04	-1000.0
Thromboxane A2 receptor signaling	3.0	317.0	105.0	-0.098	0.036	1000.0	-1000.0	-0.038	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	255.0	85.0	-0.064	0.026	1000.0	-1000.0	-0.038	-1000.0
BMP receptor signaling	3.0	264.0	81.0	-0.069	0.053	1000.0	-1000.0	-0.034	-1000.0
PDGFR-alpha signaling pathway	3.0	166.0	44.0	-0.109	0.036	1000.0	-1000.0	-0.034	-1000.0
amb2 Integrin signaling	3.0	253.0	82.0	-0.1	0.038	1000.0	-1000.0	-0.029	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	192.0	52.0	-0.115	0.05	1000.0	-1000.0	-0.031	-1000.0
FAS signaling pathway (CD95)	3.0	143.0	47.0	-0.092	0.038	1000.0	-1000.0	-0.039	-1000.0
Retinoic acid receptors-mediated signaling	3.0	182.0	58.0	-0.131	0.049	1000.0	-1000.0	-0.035	-1000.0
EPHB forward signaling	3.0	337.0	85.0	-0.056	0.101	1000.0	-1000.0	-0.054	-1000.0
Effects of Botulinum toxin	3.0	103.0	26.0	-0.111	0.025	1000.0	-1000.0	-0.005	-1000.0
Wnt signaling	3.0	21.0	7.0	-0.024	0.021	1000.0	-1000.0	-0.011	-1000.0
LPA receptor mediated events	3.0	337.0	102.0	-0.095	0.032	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	267.0	76.0	-0.063	0.047	1000.0	-1000.0	-0.051	-1000.0
Syndecan-4-mediated signaling events	3.0	210.0	67.0	-0.055	0.036	1000.0	-1000.0	-0.04	-1000.0
IGF1 pathway	3.0	227.0	57.0	-0.047	0.043	1000.0	-1000.0	-0.038	-1000.0
Plasma membrane estrogen receptor signaling	3.0	297.0	86.0	-0.107	0.048	1000.0	-1000.0	-0.049	-1000.0
E-cadherin signaling in keratinocytes	3.0	144.0	43.0	-0.048	0.028	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	295.0	78.0	-0.084	0.031	1000.0	-1000.0	-0.04	-1000.0
LPA4-mediated signaling events	2.0	32.0	12.0	-0.085	0.006	1000.0	-1000.0	-0.022	-1000.0
Caspase cascade in apoptosis	2.0	188.0	74.0	-0.081	0.058	1000.0	-1000.0	-0.025	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	298.0	136.0	-0.103	0.064	1000.0	-1000.0	-0.039	-1000.0
Coregulation of Androgen receptor activity	2.0	161.0	76.0	-0.196	0.035	1000.0	-1000.0	-0.024	-1000.0
ErbB4 signaling events	2.0	152.0	69.0	-0.111	0.054	1000.0	-1000.0	-0.034	-1000.0
BARD1 signaling events	2.0	138.0	57.0	-0.025	0.039	1000.0	-1000.0	-0.03	-1000.0
Ephrin A  reverse signaling	2.0	15.0	7.0	-0.015	0.018	1000.0	-1000.0	-0.013	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	39.0	17.0	-0.021	0.03	1000.0	-1000.0	-0.024	-1000.0
Noncanonical Wnt signaling pathway	2.0	77.0	26.0	-0.045	0.026	1000.0	-1000.0	-0.036	-1000.0
Cellular roles of Anthrax toxin	2.0	83.0	39.0	-0.05	0.026	1000.0	-1000.0	-0.018	-1000.0
Arf6 signaling events	2.0	155.0	62.0	-0.064	0.05	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by PTP1B	2.0	203.0	76.0	-0.112	0.039	1000.0	-1000.0	-0.031	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	155.0	61.0	-0.095	0.047	1000.0	-1000.0	-0.035	-1000.0
Glypican 1 network	2.0	126.0	48.0	-0.101	0.049	1000.0	-1000.0	-0.026	-1000.0
EPO signaling pathway	2.0	157.0	55.0	-0.008	0.051	1000.0	-1000.0	-0.031	-1000.0
Nectin adhesion pathway	2.0	133.0	63.0	-0.031	0.046	1000.0	-1000.0	-0.048	-1000.0
Ceramide signaling pathway	2.0	175.0	76.0	-0.064	0.059	1000.0	-1000.0	-0.025	-1000.0
TRAIL signaling pathway	2.0	113.0	48.0	-0.013	0.04	1000.0	-1000.0	-0.026	-1000.0
ceramide signaling pathway	2.0	134.0	49.0	-0.038	0.036	1000.0	-1000.0	-0.028	-1000.0
Ephrin B reverse signaling	2.0	110.0	48.0	-0.018	0.031	1000.0	-1000.0	-0.023	-1000.0
Integrins in angiogenesis	2.0	188.0	84.0	-0.064	0.049	1000.0	-1000.0	-0.039	-1000.0
Canonical Wnt signaling pathway	2.0	129.0	51.0	-0.095	0.146	1000.0	-1000.0	-0.035	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	79.0	31.0	-0.053	0.025	1000.0	-1000.0	-0.027	-1000.0
Nongenotropic Androgen signaling	2.0	117.0	52.0	-0.038	0.042	1000.0	-1000.0	-0.027	-1000.0
IL27-mediated signaling events	2.0	107.0	51.0	-0.083	0.047	1000.0	-1000.0	-0.048	-1000.0
IL2 signaling events mediated by STAT5	2.0	50.0	22.0	-0.117	0.026	1000.0	-1000.0	-0.05	-1000.0
BCR signaling pathway	2.0	270.0	99.0	-0.053	0.055	1000.0	-1000.0	-0.052	-1000.0
EGFR-dependent Endothelin signaling events	2.0	43.0	21.0	-0.026	0.048	1000.0	-1000.0	-0.038	-1000.0
PDGFR-beta signaling pathway	2.0	209.0	97.0	-0.056	0.099	1000.0	-1000.0	-0.053	-1000.0
Visual signal transduction: Rods	2.0	135.0	52.0	-0.053	0.045	1000.0	-1000.0	-0.035	-1000.0
Regulation of Androgen receptor activity	2.0	148.0	70.0	-0.232	0.033	1000.0	-1000.0	-0.041	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.0	0.026	1000.0	-1000.0	-0.014	-1000.0
Visual signal transduction: Cones	1.0	75.0	38.0	-0.016	0.029	1000.0	-1000.0	-0.009	-1000.0
Osteopontin-mediated events	1.0	45.0	38.0	-0.036	0.046	1000.0	-1000.0	-0.032	-1000.0
Syndecan-2-mediated signaling events	1.0	120.0	69.0	-0.019	0.042	1000.0	-1000.0	-0.047	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	6.0	5.0	0.014	0.03	1000.0	-1000.0	0.007	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	81.0	65.0	-0.148	0.052	1000.0	-1000.0	-0.046	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	143.0	97.0	-0.095	0.05	1000.0	-1000.0	-0.055	-1000.0
Insulin-mediated glucose transport	1.0	35.0	32.0	-0.046	0.044	1000.0	-1000.0	-0.02	-1000.0
mTOR signaling pathway	1.0	71.0	53.0	-0.054	0.053	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class III	1.0	58.0	40.0	-0.063	0.048	1000.0	-1000.0	-0.023	-1000.0
IL1-mediated signaling events	1.0	81.0	62.0	-0.014	0.062	1000.0	-1000.0	-0.039	-1000.0
S1P5 pathway	1.0	29.0	17.0	-0.01	0.026	1000.0	-1000.0	-0.013	-1000.0
HIF-2-alpha transcription factor network	1.0	44.0	43.0	-0.063	0.064	1000.0	-1000.0	-0.044	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	127.0	83.0	-0.061	0.046	1000.0	-1000.0	-0.02	-1000.0
S1P1 pathway	1.0	70.0	36.0	-0.069	0.025	1000.0	-1000.0	-0.041	-1000.0
Syndecan-3-mediated signaling events	1.0	68.0	35.0	-0.083	0.047	1000.0	-1000.0	-0.027	-1000.0
IL2 signaling events mediated by PI3K	1.0	89.0	58.0	-0.066	0.055	1000.0	-1000.0	-0.035	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	74.0	45.0	-0.041	0.052	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	185.0	125.0	-0.032	0.056	1000.0	-1000.0	-0.049	-1000.0
TCGA08_rtk_signaling	1.0	42.0	26.0	-0.047	0.069	1000.0	-1000.0	-0.013	-1000.0
Class I PI3K signaling events	1.0	112.0	73.0	-0.022	0.049	1000.0	-1000.0	-0.034	-1000.0
S1P3 pathway	1.0	66.0	42.0	-0.021	0.044	1000.0	-1000.0	-0.026	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	38.0	33.0	-0.054	0.055	1000.0	-1000.0	-0.029	-1000.0
Rapid glucocorticoid signaling	1.0	22.0	20.0	-0.009	0.029	1000.0	-1000.0	-0.002	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.017	0.017	1000.0	-1000.0	-0.009	-1000.0
FOXM1 transcription factor network	1.0	56.0	51.0	-0.045	0.055	1000.0	-1000.0	-0.107	-1000.0
S1P4 pathway	1.0	47.0	25.0	-0.024	0.039	1000.0	-1000.0	-0.023	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	23.0	17.0	-0.004	0.041	1000.0	-1000.0	-0.017	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	11.0	23.0	-0.006	0.044	1000.0	-1000.0	-0.022	-1000.0
Canonical NF-kappaB pathway	0.0	28.0	39.0	-0.039	0.06	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class II	0.0	39.0	75.0	-0.033	0.068	1000.0	-1000.0	-0.026	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	20.0	28.0	-0.01	0.047	1000.0	-1000.0	-0.021	-1000.0
Circadian rhythm pathway	0.0	2.0	22.0	-0.007	0.052	1000.0	-1000.0	-0.032	-1000.0
Aurora A signaling	0.0	24.0	60.0	-0.033	0.055	1000.0	-1000.0	-0.013	-1000.0
Arf6 downstream pathway	0.0	21.0	43.0	-0.044	0.045	1000.0	-1000.0	-0.023	-1000.0
Aurora C signaling	0.0	2.0	7.0	-0.0	0.037	1000.0	-1000.0	-0.01	-1000.0
PLK1 signaling events	0.0	58.0	85.0	-0.02	0.039	1000.0	-1000.0	-0.024	-1000.0
IFN-gamma pathway	0.0	62.0	68.0	-0.028	0.066	1000.0	-1000.0	-0.046	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	25.0	68.0	-0.047	0.066	1000.0	-1000.0	-0.029	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	36.0	37.0	-0.019	0.052	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class I	0.0	88.0	104.0	-0.044	0.066	1000.0	-1000.0	-0.026	-1000.0
TCGA08_p53	0.0	5.0	7.0	0.0	0.025	1000.0	-1000.0	-0.005	-1000.0
FoxO family signaling	0.0	51.0	64.0	-0.046	0.076	1000.0	-1000.0	-0.047	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	9.0	15.0	-0.011	0.024	1000.0	-1000.0	-0.025	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	23.0	36.0	-0.042	0.047	1000.0	-1000.0	-0.035	-1000.0
Atypical NF-kappaB pathway	0.0	16.0	31.0	-0.0	0.027	1000.0	-1000.0	-0.018	-1000.0
Regulation of p38-alpha and p38-beta	0.0	44.0	54.0	-0.041	0.058	1000.0	-1000.0	-0.044	-1000.0
Glypican 2 network	0.0	3.0	4.0	0.017	0.029	1000.0	-1000.0	0.008	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.01	0.055	1000.0	-1000.0	-0.031	-1000.0
Arf6 trafficking events	0.0	36.0	71.0	-0.046	0.048	1000.0	-1000.0	-0.027	-1000.0
Regulation of Telomerase	0.0	96.0	102.0	-0.071	0.052	1000.0	-1000.0	-0.032	-1000.0
Insulin Pathway	0.0	49.0	74.0	-0.023	0.066	1000.0	-1000.0	-0.045	-1000.0
VEGFR1 specific signals	0.0	17.0	56.0	-0.025	0.054	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by PRL	0.0	20.0	34.0	-0.047	0.036	1000.0	-1000.0	-0.04	-1000.0
p38 MAPK signaling pathway	0.0	21.0	44.0	-0.013	0.046	1000.0	-1000.0	-0.025	-1000.0
Arf1 pathway	0.0	15.0	54.0	-0.001	0.037	1000.0	-1000.0	-0.015	-1000.0
Alternative NF-kappaB pathway	0.0	1.0	13.0	-0.0	0.065	1000.0	-1000.0	-0.0	-1000.0
Aurora B signaling	0.0	44.0	67.0	-0.092	0.064	1000.0	-1000.0	-0.031	-1000.0
Total	253	19089	7203	-9.23117598167	6.44147815395	131000	-131000	-4.45502885268	-131000