rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(146), CAMP(2), CREB3(1), CREB5(9), MAPK1(4), RAF1(10), SNX13(5), SRC(2), TERF2IP(1)	4578933	181	157	52	33	38	4	6	127	6	0	0.00234	5.71e-11	3.52e-08
2	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CCND1(2), CDK4(7), CDKN1A(3), CDKN1B(1), CDKN2A(42), CFL1(2), E2F1(5), E2F2(5), MDM2(1), NXT1(2), PRB1(37), TP53(51)	3472023	158	99	114	17	80	5	6	12	54	1	8.45e-13	3.00e-09	9.25e-07
3	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MYC(5), SP1(5), SP3(1), TP53(51), WT1(8)	2913500	72	58	61	5	31	4	7	6	23	1	1.49e-07	0.000522	0.107
4	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(14), CCND1(2), CCNE1(4), CCNE2(8), CDK4(7), CDKN1B(1), CDKN2A(42), E2F1(5), E2F2(5), E2F4(3), PRB1(37)	3698385	128	88	93	20	74	2	4	15	33	0	2.94e-07	0.0195	1.000
5	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(11)	294687	11	11	11	2	8	1	1	1	0	0	0.0878	0.0863	1.000
6	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(13), CDKN2A(42), E2F1(5), MDM2(1), MYC(5), PIK3CA(10), PIK3R1(2), POLR1A(13), POLR1B(9), POLR1C(1), RAC1(20), RB1(10), TBX2(6), TP53(51), TWIST1(1)	8311519	189	115	143	28	96	9	7	15	58	4	4.69e-11	0.339	1.000
7	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(5)	211181	5	5	5	1	5	0	0	0	0	0	0.373	0.359	1.000
8	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(6), TAT(19)	1081172	31	20	30	7	23	3	2	1	2	0	0.00611	0.839	1.000
9	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(2), DNAJC3(3), EIF2S1(1), MAP3K14(6), NFKB1(6), NFKBIA(2), RELA(4), TP53(51)	3969064	75	62	65	13	35	5	5	7	22	1	0.000323	0.948	1.000
10	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(5), CHRNA1(7), SNAP25(8)	1342611	20	18	18	3	15	1	0	1	3	0	0.00173	0.954	1.000
11	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(6), FOSB(5), GRIA2(41), JUND(1), PPP1R1B(2)	1509149	55	47	52	19	33	3	2	8	9	0	0.0695	0.955	1.000
12	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(4), TPI1(1)	680838	5	5	4	1	3	0	0	2	0	0	0.339	0.972	1.000
13	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(7), DCN(18), FMOD(6), KERA(15), LUM(12)	1452696	58	44	54	22	45	4	3	3	3	0	0.0103	0.979	1.000
14	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6)	2316589	94	70	77	29	76	4	4	6	4	0	0.00260	0.984	1.000
15	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(1)	634605	3	2	3	0	0	2	0	0	1	0	0.394	0.991	1.000
16	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(2), NFYC(2), RB1(10), SP1(5), SP3(1)	2737585	21	19	21	4	4	2	2	5	6	2	0.137	0.991	1.000
17	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(7), CD3E(2), CD3G(1)	461364	10	7	10	4	8	0	0	0	2	0	0.405	0.992	1.000
18	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(4), ALDOA(2), ALDOB(14), ALDOC(4), TPI1(1)	1621282	25	20	22	6	18	2	0	2	3	0	0.0130	0.994	1.000
19	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(6), ATM(15), BAX(3), BCL2(2), CCND1(2), CCNE1(4), CDK4(7), CDKN1A(3), E2F1(5), MDM2(1), PCNA(2), RB1(10), TIMP3(5), TP53(51)	7387149	116	86	102	23	47	7	8	16	35	3	0.000353	0.994	1.000
20	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(15), GAD1(13), HDC(24), PNMT(4), TH(12), TPH1(12)	2446722	80	60	76	28	61	4	3	2	10	0	0.000490	0.995	1.000
21	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(10), IFNG(4), IL12A(4), IL12B(3), IL18(3), IL2(4)	1204739	28	18	27	9	20	2	0	1	5	0	0.0680	0.998	1.000
22	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP3(2), CASP8(9), CFL1(2), CFLAR(4), PDE6D(2)	1605213	21	19	20	7	10	1	2	5	3	0	0.348	1.000	1.000
23	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(6), IL8(1), SLPI(6)	706616	13	13	13	7	6	1	0	5	1	0	0.688	1.000	1.000
24	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(8), SEC61A2(4), SRP19(1), SRP54(4), SRP68(7), SRP72(1), SRP9(1), SRPR(4)	3136601	30	27	25	7	14	0	1	7	8	0	0.139	1.000	1.000
25	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(5), ACADM(4), ACADS(5), ECHS1(3), HADHA(6)	2246401	23	22	23	6	14	4	1	3	1	0	0.136	1.000	1.000
26	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(14), CCND1(2), CCND2(6), CCND3(2), CCNE1(4), CCNH(2), CDC25A(8), CDK4(7), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2A(42), CDKN2C(1), E2F1(5), RB1(10), RBL1(12), TFDP1(2)	6619450	125	88	99	29	56	6	7	15	39	2	0.000128	1.000	1.000
27	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(24), DAXX(9), HRAS(3), PAX3(3), PML(3), RARA(4), RB1(10), SIRT1(2), SP100(11), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TP53(51)	7715964	129	85	119	29	52	12	11	16	35	3	0.000123	1.000	1.000
28	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(5), ALDH1A2(14), BCMO1(15), RDH5(3)	1605861	37	33	32	13	25	2	1	4	5	0	0.0471	1.000	1.000
29	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(14), LPL(6), NR3C1(7), PPARG(14), RETN(3), RXRA(4), TNF(1)	2393389	49	41	46	15	29	7	0	7	6	0	0.0150	1.000	1.000
30	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(6), CDK5R1(1), DPM2(1), EGR1(4), HRAS(3), KLK2(5), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), NGFR(8), RAF1(10)	3332623	65	54	57	26	31	7	3	14	10	0	0.0731	1.000	1.000
31	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(6), NFKB1(6), NFKBIA(2), PLCB1(54), PRKCA(8), RELA(4)	3360704	80	59	72	28	59	3	3	8	7	0	0.0380	1.000	1.000
32	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(4), OXCT1(4)	1382553	9	9	9	5	6	0	0	1	2	0	0.721	1.000	1.000
33	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(2), DAG1(9), GNAQ(6), ITPKB(11)	2463787	28	24	26	10	20	0	2	2	4	0	0.0790	1.000	1.000
34	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(15), CDC25A(8), CDC25B(4), CDC25C(5), CDK4(7), CHEK1(2), MYT1(21), RB1(10), TP53(51), WEE1(2)	7203936	125	83	110	27	62	6	7	15	32	3	0.000242	1.000	1.000
35	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(8), HLA-DRA(12)	967239	22	21	20	11	18	1	0	1	2	0	0.189	1.000	1.000
36	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(4), IFNGR1(3), IFNGR2(4), JAK1(6), JAK2(8), STAT1(5)	3345739	30	22	28	9	13	1	1	6	9	0	0.362	1.000	1.000
37	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), CDC42(2), RAC1(20), WASF1(4), WASL(5)	3335798	45	40	34	11	33	2	1	7	2	0	0.0229	1.000	1.000
38	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(5), IFNG(4), IFNGR1(3), IFNGR2(4), IKBKB(4), JAK2(8), LIN7A(16), NFKB1(6), NFKBIA(2), RB1(10), RELA(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TP53(51), USH1C(22), WT1(8)	7393001	156	94	138	36	72	9	8	19	45	3	1.53e-05	1.000	1.000
39	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(3), CCR3(10), CSF2(2), HLA-DRA(12), IL3(3), IL5(4)	1245304	34	25	32	16	28	1	0	2	3	0	0.0550	1.000	1.000
40	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB1A(2), RAB27A(3), RAB3A(4), RAB4A(1), RAB5A(2)	1727342	16	14	15	7	13	1	0	1	1	0	0.352	1.000	1.000
41	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(4), PAPSS2(5), SULT1A2(2), SULT1E1(16), SULT2A1(9), SUOX(4)	2504923	40	25	38	11	28	1	0	4	7	0	0.0329	1.000	1.000
42	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(13), IARS(8), LARS(12), LARS2(5), PDHA1(4), PDHA2(20), PDHB(1)	4124613	63	48	60	16	40	7	2	7	7	0	0.0207	1.000	1.000
43	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLS2(3), GLUD1(2), GLUD2(4)	1866369	11	9	11	8	3	3	1	1	3	0	0.868	1.000	1.000
44	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(6), GBA(7), GBA3(19), GGT1(8), SHMT1(2), SHMT2(3)	2197914	45	35	41	18	30	6	0	5	4	0	0.0575	1.000	1.000
45	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(2), COQ5(2), COQ6(2), COQ7(3)	1632423	11	11	11	5	8	1	1	0	1	0	0.553	1.000	1.000
46	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(6), BAK1(1), BAX(3), BCL10(3), BCL2(2), BCL2L11(5), CASP8AP2(10), CASP9(2), CES1(21)	4401181	53	38	51	13	34	6	2	4	7	0	0.0249	1.000	1.000
47	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(17), NR0B2(6), NR1H3(3), NR1H4(14), RXRA(4)	2231872	44	31	44	16	28	7	3	4	2	0	0.0301	1.000	1.000
48	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(4), ACP2(2), ACP5(3), ACPP(9), ACPT(3), ENPP1(13), ENPP3(13), FLAD1(10), TYR(9)	3967466	66	48	63	19	44	4	2	3	13	0	0.0144	1.000	1.000
49	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(19), GGT1(8), SHMT1(2), SHMT2(3)	1666050	32	28	29	17	21	4	0	4	3	0	0.247	1.000	1.000
50	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(4), PLCD1(4), PRKCA(8), TGM2(10)	2041604	26	20	25	11	18	3	1	0	4	0	0.0518	1.000	1.000
51	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(4), CDC34(3), CUL1(5), E2F1(5), FBXW7(11), RB1(10), TFDP1(2)	3344882	40	32	39	13	17	2	5	5	9	2	0.153	1.000	1.000
52	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(8), CDC25B(4), CDK7(2), CDKN1A(3), CHEK1(2), NEK1(7), WEE1(2)	2830151	28	23	28	8	15	5	1	3	4	0	0.209	1.000	1.000
53	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(5), B3GNT1(3), FUT1(3), FUT2(3), FUT9(30), ST8SIA1(1)	2465157	45	41	41	21	31	3	3	6	2	0	0.144	1.000	1.000
54	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(8), CD80(4), HLA-DRA(12), IL10(3), IL2(4), IL4(1)	1619661	34	28	31	18	24	1	0	4	5	0	0.197	1.000	1.000
55	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(15), ATR(23), CDC25C(5), CHEK1(2), CHEK2(2), TP53(51)	6550810	98	70	87	23	56	3	5	8	25	1	0.00997	1.000	1.000
56	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(14), GOT1(6), GOT2(6), TAT(19), TYR(9)	1930880	54	34	52	25	41	5	3	1	4	0	0.177	1.000	1.000
57	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(9), ALPL(11), ALPP(10), ALPPL2(12), DHFR(2), FPGS(3), GGH(3), SPR(4)	2617919	54	37	50	24	38	5	4	1	6	0	0.0244	1.000	1.000
58	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(3), MMP14(3), MMP2(8), MMP9(7), RECK(11), TIMP1(1), TIMP2(1), TIMP3(5), TIMP4(6)	3056548	45	37	43	18	24	3	2	10	6	0	0.189	1.000	1.000
59	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(5), AASDHPPT(3), AASS(3), KARS(3)	1915095	14	14	14	6	13	0	0	1	0	0	0.538	1.000	1.000
60	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), CYCS(1), GPD2(3), SDHA(3), SDHC(3), SDHD(1), UQCRC1(4)	2730502	16	16	16	7	10	0	1	3	2	0	0.526	1.000	1.000
61	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(14), CCNE1(4), CDC34(3), CUL1(5), E2F1(5), RB1(10), SKP2(2), TFDP1(2)	3492716	45	37	45	17	25	2	4	6	6	2	0.168	1.000	1.000
62	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(34), GNAS(25), GNB1(1), PRKACA(3), PRKAR1A(3)	2676885	66	46	63	27	38	11	4	7	6	0	0.117	1.000	1.000
63	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(6), CPS1(26), GLS(2), GLUD1(2), GOT1(6)	3144518	44	32	41	15	30	4	1	7	2	0	0.0998	1.000	1.000
64	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(8), CTH(1), GOT1(6), GOT2(6), LDHA(4), LDHB(2), LDHC(5), MPST(2)	2821052	34	27	33	13	25	2	6	0	1	0	0.124	1.000	1.000
65	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(3), ECHS1(3), EHHADH(6), HADH(2), HADHA(6), HSD17B10(2), HSD17B4(6), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(4), SIRT7(3), VNN2(17)	4858988	56	47	54	17	37	6	3	6	4	0	0.0364	1.000	1.000
66	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(11), CAPN1(4), CAPNS1(3), CAPNS2(1), CDK5(6), CDK5R1(1), CSNK1A1(3), CSNK1D(3), GSK3B(3), MAPT(11)	3688556	46	38	45	18	30	2	1	6	7	0	0.118	1.000	1.000
67	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(2), CSF3(4), EPO(5), FLT3(35), IGF1(10), IL11(3), IL1A(5), IL3(3), IL6(2), IL9(1), KITLG(11), TGFB1(2), TGFB2(3), TGFB3(3)	3376428	89	62	83	31	52	6	5	13	13	0	0.00645	1.000	1.000
68	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(4), ENO2(5), ENO3(3), FARS2(6), GOT1(6), GOT2(6), PAH(12), TAT(19), YARS(3)	3424502	64	48	60	26	43	6	2	6	7	0	0.0240	1.000	1.000
69	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(3), ACVR1C(10), AKT1(4), AKT2(8), AKT3(3), ARRB1(5), ARRB2(6), ATF2(6), ATF4(9), BDNF(4), BRAF(146), CACNA1A(38), CACNA1B(35), CACNA1C(62), CACNA1D(33), CACNA1E(111), CACNA1F(23), CACNA1G(36), CACNA1H(29), CACNA1I(39), CACNA1S(53), CACNA2D1(16), CACNA2D2(16), CACNA2D3(60), CACNA2D4(25), CACNB1(4), CACNB2(14), CACNB3(2), CACNB4(12), CACNG1(3), CACNG2(12), CACNG3(24), CACNG4(4), CACNG5(10), CACNG6(6), CACNG7(6), CACNG8(1), CASP3(2), CD14(5), CDC25B(4), CDC42(2), CHUK(2), CRK(3), CRKL(3), DAXX(9), DDIT3(2), DUSP1(1), DUSP10(7), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP4(2), DUSP5(2), DUSP6(2), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(1), EGF(21), EGFR(25), ELK1(3), FAS(6), FASLG(15), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(7), FGF17(3), FGF18(3), FGF19(3), FGF2(1), FGF20(2), FGF21(5), FGF23(10), FGF3(6), FGF4(2), FGF5(10), FGF6(6), FGF7(7), FGF8(1), FGF9(5), FGFR1(11), FGFR2(32), FGFR3(9), FGFR4(11), FLNA(21), FLNB(41), FLNC(65), FOS(2), GADD45B(2), GNA12(3), GRB2(2), HRAS(3), IKBKB(4), IL1A(5), IL1B(8), IL1R1(13), IL1R2(8), JUN(1), JUND(1), KRAS(5), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP2K5(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K10(9), MAP3K12(3), MAP3K13(15), MAP3K14(6), MAP3K2(6), MAP3K3(8), MAP3K4(17), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP4K1(11), MAP4K2(7), MAP4K3(11), MAP4K4(16), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK7(4), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MAPT(11), MEF2C(4), MKNK1(6), MKNK2(3), MOS(6), MRAS(2), MYC(5), NF1(46), NFATC2(11), NFATC4(17), NFKB1(6), NFKB2(3), NLK(5), NR4A1(4), NRAS(86), NTF3(6), NTRK1(16), NTRK2(10), PAK1(4), PAK2(7), PDGFA(1), PDGFB(6), PDGFRA(34), PDGFRB(21), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PPM1A(3), PPM1B(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PPP5C(3), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKX(3), PTPN5(13), PTPN7(3), PTPRR(30), RAC1(20), RAC2(3), RAF1(10), RAP1A(2), RAP1B(1), RAPGEF2(9), RASA1(4), RASA2(15), RASGRF1(21), RASGRF2(24), RASGRP1(11), RASGRP2(7), RASGRP3(12), RASGRP4(11), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA4(4), RPS6KA5(7), RPS6KA6(19), RRAS(1), RRAS2(1), SOS1(10), SOS2(13), SRF(3), STK3(1), STK4(4), STMN1(3), TAOK1(10), TAOK2(27), TAOK3(3), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF1A(4), TP53(51), TRAF2(2), TRAF6(4)	115574449	2479	269	2159	1223	1466	201	109	386	309	8	2.10e-05	1.000	1.000
70	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(8), ACTG1(6), ACTN1(8), ACTN2(20), ACTN3(3), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), ARHGAP5(13), BCAR1(5), BCL2(2), BIRC2(6), BIRC3(7), BRAF(146), CAPN2(5), CAV1(1), CAV3(2), CCND1(2), CCND2(6), CCND3(2), CDC42(2), CHAD(3), COL11A1(71), COL11A2(45), COL1A1(48), COL1A2(44), COL2A1(42), COL3A1(81), COL4A1(64), COL4A2(35), COL4A4(114), COL4A6(42), COL5A1(80), COL5A2(54), COL5A3(75), COL6A1(11), COL6A2(24), COL6A3(67), COL6A6(62), COMP(8), CRK(3), CRKL(3), CTNNB1(14), DIAPH1(9), DOCK1(17), EGF(21), EGFR(25), ELK1(3), ERBB2(9), FARP2(4), FIGF(5), FLNA(21), FLNB(41), FLNC(65), FLT1(38), FN1(25), FYN(7), GRB2(2), GSK3B(3), HGF(29), HRAS(3), IBSP(9), IGF1(10), IGF1R(14), ILK(2), ITGA1(24), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGA7(25), ITGA8(37), ITGA9(13), ITGAV(9), ITGB1(4), ITGB3(15), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(6), ITGB8(20), JUN(1), KDR(55), LAMA1(46), LAMA2(68), LAMA3(67), LAMA4(12), LAMA5(38), LAMB1(14), LAMB2(13), LAMB3(26), LAMB4(46), LAMC1(12), LAMC2(22), LAMC3(10), MAP2K1(14), MAPK1(4), MAPK10(9), MAPK3(4), MAPK8(1), MAPK9(3), MET(23), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(46), MYLK2(12), MYLPF(2), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARVA(2), PARVB(4), PARVG(3), PDGFA(1), PDGFB(6), PDGFC(16), PDGFD(6), PDGFRA(34), PDGFRB(21), PDPK1(3), PGF(1), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PIP5K1C(9), PPP1CA(1), PPP1CB(5), PPP1CC(1), PPP1R12A(4), PRKCA(8), PRKCG(16), PTEN(23), PTK2(7), PXN(2), RAC1(20), RAC2(3), RAF1(10), RAP1A(2), RAP1B(1), RAPGEF1(12), RELN(88), RHOA(2), ROCK1(7), ROCK2(11), SHC1(2), SHC2(6), SHC3(14), SHC4(2), SOS1(10), SOS2(13), SPP1(7), SRC(2), THBS1(30), THBS2(12), THBS3(11), THBS4(19), TLN1(12), TLN2(27), TNC(35), TNN(53), TNR(79), TNXB(128), VASP(3), VAV1(19), VAV2(3), VAV3(14), VCL(8), VEGFA(4), VEGFB(2), VEGFC(23), VTN(8), VWF(56), ZYX(8)	151742001	3629	265	3314	1458	2441	232	108	418	416	14	<1.00e-15	1.000	1.000
71	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(8), ACTN2(20), ACTN3(3), ACTN4(5), APC(25), APC2(12), ARAF(5), ARHGEF1(1), ARHGEF12(12), ARHGEF4(4), ARHGEF6(10), ARHGEF7(6), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC5(1), BAIAP2(7), BCAR1(5), BDKRB1(6), BDKRB2(9), BRAF(146), CD14(5), CDC42(2), CFL1(2), CHRM1(5), CHRM2(25), CHRM3(26), CHRM4(6), CHRM5(7), CRK(3), CRKL(3), CSK(1), CYFIP1(9), CYFIP2(25), DIAPH1(9), DIAPH2(6), DIAPH3(17), DOCK1(17), EGF(21), EGFR(25), EZR(5), F2(11), F2R(8), FGD1(5), FGD3(9), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(7), FGF17(3), FGF18(3), FGF19(3), FGF2(1), FGF20(2), FGF21(5), FGF23(10), FGF3(6), FGF4(2), FGF5(10), FGF6(6), FGF7(7), FGF8(1), FGF9(5), FGFR1(11), FGFR2(32), FGFR3(9), FGFR4(11), FN1(25), GIT1(4), GNA12(3), GNA13(1), GSN(6), HRAS(3), IQGAP1(9), IQGAP2(27), IQGAP3(12), ITGA1(24), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGA7(25), ITGA8(37), ITGA9(13), ITGAD(30), ITGAE(21), ITGAL(28), ITGAM(23), ITGAV(9), ITGAX(23), ITGB1(4), ITGB2(16), ITGB3(15), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(6), ITGB8(20), KRAS(5), LIMK1(5), LIMK2(12), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MOS(6), MRAS(2), MSN(2), MYH10(14), MYH14(23), MYH9(11), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(46), MYLK2(12), MYLPF(2), NCKAP1(5), NCKAP1L(41), NRAS(86), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDGFA(1), PDGFB(6), PDGFRA(34), PDGFRB(21), PFN4(1), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PPP1CA(1), PPP1CB(5), PPP1CC(1), PPP1R12A(4), PPP1R12B(7), PTK2(7), PXN(2), RAC1(20), RAC2(3), RAF1(10), RDX(3), RHOA(2), ROCK1(7), ROCK2(11), RRAS(1), RRAS2(1), SCIN(9), SLC9A1(5), SOS1(10), SOS2(13), SSH1(15), SSH2(7), SSH3(3), TIAM1(27), TIAM2(26), VAV1(19), VAV2(3), VAV3(14), VCL(8), WAS(8), WASF1(4), WASF2(5), WASL(5)	112442381	2142	261	1845	954	1271	132	108	399	226	6	1.78e-08	1.000	1.000
72	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(5), BRAF(146), CACNA1A(38), CRH(3), CRHR1(7), GNA11(8), GNA12(3), GNA13(1), GNAI1(2), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAS(25), GNAZ(7), GRIA1(45), GRIA2(41), GRIA3(24), GRID2(59), GRM1(16), GRM5(15), GUCY1A2(21), GUCY1A3(32), GUCY1B3(7), GUCY2C(38), GUCY2D(9), GUCY2F(23), HRAS(3), IGF1(10), IGF1R(14), ITPR1(36), ITPR2(20), ITPR3(11), KRAS(5), LYN(10), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), NOS1(74), NOS3(19), NPR1(18), NPR2(20), NRAS(86), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PPP2CB(2), PPP2R1A(4), PPP2R1B(3), PPP2R2B(6), PPP2R2C(8), PRKCA(8), PRKCG(16), PRKG1(14), PRKG2(16), RAF1(10), RYR1(109)	44741430	1365	258	1067	608	807	74	73	270	137	4	3.18e-08	1.000	1.000
73	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(5), BRAF(146), CASP3(2), CD244(10), CD247(4), CD48(6), CSF2(2), FAS(6), FASLG(15), FCER1G(1), FCGR3A(7), FCGR3B(9), FYN(7), GRB2(2), GZMB(3), HLA-A(3), HLA-C(9), HLA-E(1), HLA-G(6), HRAS(3), ICAM1(2), ICAM2(4), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), IFNAR1(2), IFNAR2(14), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), ITGAL(28), ITGB2(16), KIR2DL1(29), KIR3DL2(45), KLRC1(4), KLRC2(14), KLRD1(5), KLRK1(8), KRAS(5), LAT(2), LCK(15), LCP2(9), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MICA(4), MICB(7), NCR1(17), NCR2(13), NCR3(4), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NRAS(86), PAK1(4), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLCG1(8), PLCG2(27), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRF1(11), PRKCA(8), PRKCG(16), PTK2B(10), PTPN11(10), PTPN6(5), RAC1(20), RAC2(3), RAF1(10), SH2D1A(3), SH2D1B(4), SH3BP2(2), SHC1(2), SHC2(6), SHC3(14), SHC4(2), SOS1(10), SOS2(13), SYK(14), TNF(1), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(4), TNFRSF10D(9), TNFSF10(8), TYROBP(4), ULBP1(2), ULBP2(1), ULBP3(5), VAV1(19), VAV2(3), VAV3(14), ZAP70(7)	46198577	1124	257	867	418	599	65	70	267	122	1	6.98e-08	1.000	1.000
74	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(19), ADORA1(6), ADORA2A(3), ADORA2B(1), ADORA3(15), ADRA1A(9), ADRA1B(4), ADRA2A(3), ADRA2B(10), ADRA2C(2), ADRB1(5), ADRB2(3), AGTR1(10), AGTR2(9), AVPR1A(4), AVPR1B(11), BDKRB1(6), BDKRB2(9), BRS3(5), C3AR1(5), C5AR1(10), CALCR(18), CALCRL(19), CCKAR(11), CCKBR(11), CGA(1), CHRM1(5), CHRM2(25), CHRM3(26), CHRM4(6), CHRM5(7), CNR1(13), CNR2(5), CRHR1(7), CRHR2(4), CTSG(4), CYSLTR1(5), CYSLTR2(4), DRD1(9), DRD2(14), DRD3(6), DRD4(1), DRD5(25), EDNRA(10), EDNRB(7), F2(11), F2R(8), F2RL1(16), F2RL2(8), F2RL3(4), FPR1(21), FSHB(8), FSHR(19), GABBR1(8), GABBR2(12), GABRA1(18), GABRA2(18), GABRA3(22), GABRA4(15), GABRA5(4), GABRA6(28), GABRB1(17), GABRB2(25), GABRB3(22), GABRD(5), GABRE(23), GABRG1(36), GABRG2(17), GABRG3(9), GABRP(16), GABRQ(9), GABRR1(10), GALR1(5), GALR3(2), GH1(3), GH2(10), GHR(40), GHRHR(5), GHSR(11), GIPR(3), GLP1R(13), GLP2R(15), GLRA1(13), GLRA2(6), GLRA3(17), GLRB(29), GNRHR(2), GPR156(13), GPR35(6), GPR50(19), GPR63(9), GPR83(13), GRIA1(45), GRIA2(41), GRIA3(24), GRIA4(26), GRID1(28), GRID2(59), GRIK1(27), GRIK2(29), GRIK3(32), GRIK4(16), GRIK5(9), GRIN1(8), GRIN2A(105), GRIN2B(57), GRIN2C(8), GRIN2D(10), GRIN3A(51), GRIN3B(4), GRM1(16), GRM2(13), GRM3(62), GRM4(21), GRM5(15), GRM6(31), GRM7(40), GRM8(48), GRPR(7), GZMA(13), HCRTR1(2), HCRTR2(33), HRH1(14), HRH2(3), HRH3(5), HRH4(6), HTR1A(10), HTR1B(1), HTR1D(6), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(13), HTR4(9), HTR5A(19), HTR6(1), HTR7(9), LEP(4), LEPR(29), LHCGR(27), LTB4R(1), MAS1(4), MC2R(5), MC3R(7), MC4R(1), MC5R(8), MCHR1(4), MCHR2(20), MLNR(1), MTNR1A(10), MTNR1B(8), NMBR(7), NMUR1(8), NMUR2(16), NPBWR1(3), NPBWR2(11), NPFFR1(1), NPFFR2(13), NPY1R(29), NPY2R(13), NPY5R(24), NR3C1(7), NTSR1(7), NTSR2(2), OPRD1(3), OPRK1(24), OPRL1(8), OPRM1(5), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(9), P2RX4(3), P2RX5(8), P2RX7(4), P2RY1(5), P2RY10(7), P2RY13(4), P2RY14(8), P2RY2(8), P2RY4(2), P2RY6(2), P2RY8(7), PARD3(18), PPYR1(14), PRL(3), PRLHR(1), PRLR(35), PRSS1(27), PRSS3(6), PTAFR(2), PTGDR(11), PTGER2(7), PTGER3(6), PTGER4(2), PTGFR(21), PTGIR(5), PTH2R(16), RXFP1(19), RXFP2(25), SCTR(6), SSTR1(10), SSTR2(7), SSTR3(11), SSTR4(4), SSTR5(5), TAAR1(3), TAAR2(11), TAAR5(4), TAAR6(11), TAAR8(7), TAAR9(3), TACR1(8), TACR2(7), TACR3(27), TBXA2R(4), THRA(2), THRB(18), TRHR(23), TRPV1(2), TSHB(6), TSHR(8), UTS2R(1), VIPR1(7), VIPR2(7)	90067857	2847	255	2615	1708	1973	240	93	256	279	6	4.38e-13	1.000	1.000
75	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(34), ADCY8(55), ARAF(5), ATF4(9), BRAF(146), CACNA1C(62), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CREBBP(24), EP300(18), GNAQ(6), GRIA1(45), GRIA2(41), GRIN1(8), GRIN2A(105), GRIN2B(57), GRIN2C(8), GRIN2D(10), GRM1(16), GRM5(15), HRAS(3), ITPR1(36), ITPR2(20), ITPR3(11), KRAS(5), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), NRAS(86), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PPP1CA(1), PPP1CB(5), PPP1CC(1), PPP1R12A(4), PPP1R1A(5), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKX(3), RAF1(10), RAP1A(2), RAP1B(1), RAPGEF3(14), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA6(19)	40259487	1197	255	922	547	667	81	77	264	104	4	7.94e-05	1.000	1.000
76	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(20), ACACB(23), AKT1(4), AKT2(8), AKT3(3), ARAF(5), BRAF(146), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CBL(10), CBLB(21), CBLC(15), CRK(3), CRKL(3), EIF4EBP1(1), ELK1(3), EXOC7(9), FASN(23), FBP1(3), FBP2(2), FLOT1(2), FOXO1(6), G6PC(5), G6PC2(4), GCK(17), GRB2(2), GSK3B(3), GYS1(3), GYS2(24), HRAS(3), IKBKB(4), INPP5D(37), INSR(26), IRS1(5), IRS2(3), IRS4(13), KRAS(5), LIPE(9), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK10(9), MAPK3(4), MAPK8(1), MAPK9(3), MKNK1(6), MKNK2(3), NRAS(86), PCK1(25), PCK2(6), PDE3A(29), PDE3B(6), PDPK1(3), PFKL(4), PFKM(2), PFKP(2), PHKA1(24), PHKA2(9), PHKB(10), PHKG1(1), PHKG2(3), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PKLR(13), PKM2(7), PPARGC1A(23), PPP1CA(1), PPP1CB(5), PPP1CC(1), PPP1R3A(62), PPP1R3B(6), PPP1R3C(4), PPP1R3D(3), PRKAA1(1), PRKAA2(30), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(4), PRKACG(11), PRKAG1(3), PRKAG2(8), PRKAG3(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(7), PRKX(3), PTPN1(4), PTPRF(32), PYGB(3), PYGL(9), PYGM(12), RAF1(10), RAPGEF1(12), RHEB(1), RHOQ(1), RPS6(1), RPS6KB1(3), RPS6KB2(2), SH2B2(4), SHC1(2), SHC2(6), SHC3(14), SHC4(2), SLC2A4(9), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SORBS1(15), SOS1(10), SOS2(13), SREBF1(5), TRIP10(5), TSC1(9), TSC2(12)	65394299	1261	254	1012	480	683	83	78	289	126	2	2.06e-08	1.000	1.000
77	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(8), ACTG1(6), CHAD(3), COL11A1(71), COL11A2(45), COL17A1(28), COL1A1(48), COL1A2(44), COL2A1(42), COL3A1(81), COL4A1(64), COL4A2(35), COL4A4(114), COL4A6(42), COL5A1(80), COL5A2(54), COL5A3(75), COL6A1(11), COL6A2(24), COL6A3(67), COL6A6(62), COMP(8), DES(9), DSC1(48), DSC2(43), DSC3(47), DSG1(63), DSG2(25), DSG3(65), DSG4(66), FN1(25), GJA1(9), GJA10(17), GJA3(1), GJA4(4), GJA5(10), GJA8(19), GJA9(3), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GJB7(2), GJC1(6), GJC3(2), GJD2(5), IBSP(9), INA(7), ITGA6(10), ITGB4(22), KRT1(20), KRT10(14), KRT12(10), KRT13(13), KRT14(3), KRT15(9), KRT16(12), KRT17(9), KRT18(4), KRT2(18), KRT20(7), KRT23(10), KRT24(7), KRT25(12), KRT27(6), KRT28(13), KRT3(16), KRT31(9), KRT32(13), KRT33A(6), KRT33B(4), KRT34(11), KRT35(11), KRT36(18), KRT37(13), KRT38(9), KRT39(16), KRT4(21), KRT40(7), KRT5(16), KRT6A(15), KRT6B(9), KRT6C(16), KRT7(5), KRT71(19), KRT72(11), KRT73(16), KRT74(16), KRT75(16), KRT76(18), KRT77(14), KRT78(24), KRT79(8), KRT8(7), KRT81(4), KRT82(6), KRT83(16), KRT84(12), KRT85(7), KRT86(8), KRT9(23), LAMA1(46), LAMA2(68), LAMA3(67), LAMA4(12), LAMA5(38), LAMB1(14), LAMB2(13), LAMB3(26), LAMB4(46), LAMC1(12), LAMC2(22), LAMC3(10), LMNA(7), LMNB1(1), LMNB2(4), NES(24), PRPH(1), RELN(88), SPP1(7), THBS1(30), THBS2(12), THBS3(11), THBS4(19), TNC(35), TNN(53), TNR(79), TNXB(128), VIM(5), VTN(8), VWF(56)	102160381	3108	253	2941	1287	2264	225	78	215	315	11	3.11e-15	1.000	1.000
78	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(13), ABL2(11), AKT1(4), AKT2(8), AKT3(3), ARAF(5), AREG(8), BRAF(146), BTC(2), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CBL(10), CBLB(21), CBLC(15), CDKN1A(3), CDKN1B(1), CRK(3), CRKL(3), EGF(21), EGFR(25), EIF4EBP1(1), ELK1(3), ERBB2(9), ERBB3(5), ERBB4(54), EREG(3), GAB1(8), GRB2(2), GSK3B(3), HBEGF(1), HRAS(3), JUN(1), KRAS(5), MAP2K1(14), MAP2K2(5), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK3(4), MAPK8(1), MAPK9(3), MYC(5), NCK1(2), NCK2(4), NRAS(86), NRG1(15), NRG2(7), NRG3(24), NRG4(1), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLCG1(8), PLCG2(27), PRKCA(8), PRKCG(16), PTK2(7), RAF1(10), RPS6KB1(3), RPS6KB2(2), SHC1(2), SHC2(6), SHC3(14), SHC4(2), SOS1(10), SOS2(13), SRC(2), STAT5A(3), STAT5B(6), TGFA(2)	41999240	931	249	688	319	460	54	70	256	90	1	5.74e-07	1.000	1.000
79	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(16), CD36(6), CD44(5), CD47(1), CHAD(3), COL11A1(71), COL11A2(45), COL1A1(48), COL1A2(44), COL2A1(42), COL3A1(81), COL4A1(64), COL4A2(35), COL4A4(114), COL4A6(42), COL5A1(80), COL5A2(54), COL5A3(75), COL6A1(11), COL6A2(24), COL6A3(67), COL6A6(62), DAG1(9), FN1(25), FNDC1(43), FNDC3A(11), FNDC4(5), FNDC5(3), GP5(7), GP6(5), GP9(6), HMMR(4), HSPG2(30), IBSP(9), ITGA1(24), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGA7(25), ITGA8(37), ITGA9(13), ITGAV(9), ITGB1(4), ITGB3(15), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(6), ITGB8(20), LAMA1(46), LAMA2(68), LAMA3(67), LAMA4(12), LAMA5(38), LAMB1(14), LAMB2(13), LAMB3(26), LAMB4(46), LAMC1(12), LAMC2(22), LAMC3(10), RELN(88), SDC1(3), SDC2(2), SDC3(7), SDC4(3), SPP1(7), SV2A(15), SV2B(29), SV2C(22), THBS1(30), THBS2(12), THBS3(11), THBS4(19), TNC(35), TNN(53), TNR(79), TNXB(128), VTN(8), VWF(56)	91685767	2465	248	2352	1006	1779	146	73	175	280	12	3.94e-07	1.000	1.000
80	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(2), ACVR1B(3), ACVR2A(4), ACVR2B(3), AMHR2(16), BMP2(7), BMP7(5), BMPR1A(2), BMPR1B(4), BMPR2(6), CCL1(1), CCL11(3), CCL14(2), CCL15(3), CCL16(2), CCL18(1), CCL2(2), CCL20(2), CCL21(2), CCL22(1), CCL23(1), CCL24(3), CCL25(1), CCL26(2), CCL27(2), CCL28(1), CCL7(4), CCL8(3), CCR1(10), CCR2(17), CCR3(10), CCR4(9), CCR5(10), CCR6(3), CCR7(4), CCR8(8), CCR9(5), CD27(3), CD40(4), CD40LG(2), CLCF1(1), CNTF(2), CNTFR(4), CRLF2(9), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(20), CSF2RB(24), CSF3(4), CSF3R(9), CX3CL1(5), CX3CR1(17), CXCL10(3), CXCL11(1), CXCL12(3), CXCL13(2), CXCL14(3), CXCL3(2), CXCL5(3), CXCL6(2), CXCL9(3), CXCR3(4), CXCR4(3), CXCR6(4), EDA(2), EDA2R(4), EDAR(7), EGF(21), EGFR(25), EPO(5), EPOR(1), FAS(6), FASLG(15), FLT1(38), FLT3(35), FLT3LG(1), FLT4(30), GDF5(16), GH1(3), GH2(10), GHR(40), HGF(29), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), IFNAR1(2), IFNAR2(14), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(9), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(3), IL15(3), IL15RA(6), IL17A(8), IL17B(4), IL17RA(6), IL17RB(2), IL18(3), IL18R1(21), IL18RAP(26), IL19(2), IL1A(5), IL1B(8), IL1R1(13), IL1R2(8), IL1RAP(3), IL2(4), IL20(4), IL20RA(11), IL21(6), IL21R(18), IL22(2), IL22RA1(12), IL22RA2(3), IL23A(2), IL23R(7), IL25(1), IL26(4), IL28A(1), IL28B(5), IL28RA(4), IL29(1), IL2RA(5), IL2RB(12), IL2RG(3), IL3(3), IL3RA(7), IL4(1), IL4R(16), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL6ST(10), IL7(4), IL7R(34), IL8(1), IL9(1), IL9R(6), INHBA(19), INHBB(9), INHBC(12), INHBE(5), KDR(55), KIT(12), KITLG(11), LEP(4), LEPR(29), LIF(1), LIFR(39), LTA(4), LTB(3), LTBR(1), MET(23), MPL(8), NGFR(8), OSM(5), OSMR(39), PDGFB(6), PDGFC(16), PDGFRA(34), PDGFRB(21), PF4V1(1), PLEKHO2(4), PPBP(5), PRL(3), PRLR(35), RELT(2), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(4), TNFRSF10D(9), TNFRSF11A(5), TNFRSF11B(15), TNFRSF12A(1), TNFRSF13B(10), TNFRSF14(3), TNFRSF17(7), TNFRSF18(3), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(11), TNFRSF25(6), TNFRSF4(4), TNFRSF6B(4), TNFRSF8(19), TNFRSF9(4), TNFSF10(8), TNFSF11(5), TNFSF13B(2), TNFSF14(9), TNFSF15(8), TNFSF18(9), TNFSF4(5), TNFSF8(3), TNFSF9(4), TPO(47), TSLP(2), VEGFA(4), VEGFB(2), VEGFC(23), XCL1(1), XCL2(2), XCR1(6)	72316319	1782	246	1697	904	1238	130	45	151	217	1	2.26e-05	1.000	1.000
81	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY7(11), ADCY8(55), ADCY9(10), ADORA2A(3), ADORA2B(1), ADRA1A(9), ADRA1B(4), ADRA1D(5), ADRB1(5), ADRB2(3), AGTR1(10), ATP2A1(12), ATP2A2(13), ATP2A3(15), ATP2B1(7), ATP2B2(28), ATP2B3(9), ATP2B4(16), AVPR1A(4), AVPR1B(11), BDKRB1(6), BDKRB2(9), BST1(2), CACNA1A(38), CACNA1B(35), CACNA1C(62), CACNA1D(33), CACNA1E(111), CACNA1F(23), CACNA1G(36), CACNA1H(29), CACNA1I(39), CACNA1S(53), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CCKAR(11), CCKBR(11), CD38(6), CHRM1(5), CHRM2(25), CHRM3(26), CHRM5(7), CHRNA7(3), CYSLTR1(5), CYSLTR2(4), DRD1(9), EDNRA(10), EDNRB(7), EGFR(25), ERBB2(9), ERBB3(5), ERBB4(54), F2R(8), GNA11(8), GNA14(6), GNA15(6), GNAL(2), GNAQ(6), GNAS(25), GRIN1(8), GRIN2A(105), GRIN2C(8), GRIN2D(10), GRM1(16), GRM5(15), GRPR(7), HRH1(14), HRH2(3), HTR2A(11), HTR2B(2), HTR2C(13), HTR4(9), HTR5A(19), HTR6(1), HTR7(9), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), LHCGR(27), MYLK(46), MYLK2(12), NOS1(74), NOS3(19), NTSR1(7), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(9), P2RX4(3), P2RX5(8), P2RX7(4), PDE1A(43), PDE1B(16), PDE1C(52), PDGFRA(34), PDGFRB(21), PHKA1(24), PHKA2(9), PHKB(10), PHKG1(1), PHKG2(3), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLCD1(4), PLCD3(4), PLCD4(4), PLCE1(57), PLCG1(8), PLCG2(27), PLCZ1(30), PPID(1), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKX(3), PTAFR(2), PTGER3(6), PTGFR(21), PTK2B(10), RYR1(109), RYR2(99), RYR3(90), SLC25A6(2), SLC8A1(34), SLC8A2(14), SLC8A3(43), SPHK1(2), SPHK2(7), TACR1(8), TACR2(7), TACR3(27), TBXA2R(4), TNNC1(2), TNNC2(4), TRHR(23), TRPC1(6), VDAC1(1), VDAC2(1), VDAC3(1)	108941564	2728	245	2561	1680	1911	197	96	206	309	9	5.38e-06	1.000	1.000
82	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(13), ABLIM1(13), ABLIM2(8), ABLIM3(8), ARHGEF12(12), CDC42(2), CDK5(6), CFL1(2), CXCL12(3), CXCR4(3), DCC(95), DPYSL2(4), DPYSL5(17), EFNA1(1), EFNA2(1), EFNA3(4), EFNA5(4), EFNB1(2), EFNB3(3), EPHA1(22), EPHA2(18), EPHA3(33), EPHA4(21), EPHA5(8), EPHA6(67), EPHA7(52), EPHA8(20), EPHB1(29), EPHB2(34), EPHB3(17), EPHB4(14), EPHB6(27), FES(8), FYN(7), GNAI1(2), GNAI2(6), GNAI3(2), GSK3B(3), HRAS(3), ITGB1(4), KRAS(5), L1CAM(11), LIMK1(5), LIMK2(12), LRRC4C(47), MAPK1(4), MAPK3(4), MET(23), NCK1(2), NCK2(4), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NGEF(12), NRAS(86), NRP1(22), NTN4(17), NTNG1(13), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLXNA1(12), PLXNA2(9), PLXNA3(16), PLXNB1(22), PLXNB2(16), PLXNB3(6), PLXNC1(17), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PTK2(7), RAC1(20), RAC2(3), RASA1(4), RGS3(16), RHOA(2), RHOD(2), RND1(5), ROBO1(24), ROBO2(43), ROBO3(20), ROCK1(7), ROCK2(11), SEMA3A(13), SEMA3B(2), SEMA3C(2), SEMA3D(12), SEMA3E(28), SEMA3F(11), SEMA3G(15), SEMA4A(9), SEMA4B(4), SEMA4C(12), SEMA4D(10), SEMA4F(7), SEMA4G(8), SEMA5A(18), SEMA5B(20), SEMA6A(9), SEMA6B(8), SEMA6C(8), SEMA6D(6), SEMA7A(4), SLIT1(17), SLIT2(62), SLIT3(60), SRGAP1(6), SRGAP2(8), SRGAP3(39), UNC5A(11), UNC5B(10), UNC5C(17), UNC5D(32)	79851651	1762	241	1572	836	1151	135	80	215	178	3	2.60e-06	1.000	1.000
83	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(8), ACTG1(6), ACTN1(8), ACTN2(20), ACTN3(3), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), AMOTL1(3), ASH1L(34), CASK(7), CDC42(2), CDK4(7), CGN(10), CLDN1(5), CLDN10(7), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(8), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(1), CLDN3(2), CLDN4(11), CLDN6(8), CLDN7(1), CLDN8(4), CLDN9(1), CSDA(4), CSNK2A1(4), CSNK2A2(1), CSNK2B(2), CTNNA1(3), CTNNA2(30), CTNNA3(38), CTNNB1(14), CTTN(4), EPB41(8), EPB41L1(13), EPB41L2(19), EPB41L3(6), EXOC3(6), EXOC4(11), F11R(7), GNAI1(2), GNAI2(6), GNAI3(2), HCLS1(13), HRAS(3), IGSF5(11), INADL(40), JAM2(11), JAM3(3), KRAS(5), LLGL1(5), LLGL2(14), MAGI1(31), MAGI2(24), MAGI3(13), MLLT4(16), MPDZ(13), MPP5(1), MRAS(2), MYH1(101), MYH10(14), MYH11(31), MYH13(52), MYH14(23), MYH15(64), MYH2(97), MYH3(30), MYH4(96), MYH6(37), MYH7(56), MYH7B(26), MYH8(64), MYH9(11), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLPF(2), NRAS(86), OCLN(7), PARD3(18), PARD6A(1), PARD6B(2), PARD6G(3), PPM1J(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(3), PPP2R2B(6), PPP2R2C(8), PPP2R3A(10), PPP2R3B(5), PPP2R4(2), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(20), PRKCZ(7), PTEN(23), RAB3B(1), RHOA(2), RRAS(1), RRAS2(1), SPTAN1(10), SRC(2), SYMPK(7), TJAP1(5), TJP1(13), TJP2(10), TJP3(20), VAPA(2), YES1(4)	79071306	1650	241	1471	934	1047	135	78	193	192	5	0.0329	1.000	1.000
84	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(13), ACTN1(8), ACTR2(3), ACTR3(2), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(2), ARHGEF6(10), ARHGEF7(6), BCAR1(5), BRAF(146), CAV1(1), CDC42(2), CDKN2A(42), CRK(3), CSE1L(5), DOCK1(17), EPHB2(34), FYN(7), GRB2(2), GRB7(9), ILK(2), ITGA1(24), ITGA10(12), ITGA11(19), ITGA2(13), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGA7(25), ITGA8(37), ITGA9(13), ITGB3BP(3), MAP2K4(4), MAP2K7(5), MAP3K11(6), MAPK1(4), MAPK10(9), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3), MRAS(2), MYLK(46), MYLK2(12), P4HB(4), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(14), PKLR(13), PLCG1(8), PLCG2(27), PTEN(23), PTK2(7), RAF1(10), RALA(1), RHO(2), ROCK1(7), ROCK2(11), SHC1(2), SOS1(10), SOS2(13), SRC(2), TERF2IP(1), TLN1(12), TLN2(27), VASP(3), WAS(8), ZYX(8)	49765278	995	239	803	376	534	65	38	226	131	1	1.21e-06	1.000	1.000
85	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ADRB1(5), CSNK1D(3), DRD1(9), DRD2(14), EGF(21), EGFR(25), GJA1(9), GJD2(5), GNA11(8), GNAI1(2), GNAI2(6), GNAI3(2), GNAQ(6), GNAS(25), GRB2(2), GRM1(16), GRM5(15), GUCY1A2(21), GUCY1A3(32), GUCY1B3(7), GUCY2C(38), GUCY2D(9), GUCY2F(23), HRAS(3), HTR2A(11), HTR2B(2), HTR2C(13), ITPR1(36), ITPR2(20), ITPR3(11), KRAS(5), MAP2K1(14), MAP2K2(5), MAP2K5(4), MAP3K2(6), MAPK1(4), MAPK3(4), MAPK7(4), NPR1(18), NPR2(20), NRAS(86), PDGFA(1), PDGFB(6), PDGFC(16), PDGFD(6), PDGFRA(34), PDGFRB(21), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKG1(14), PRKG2(16), PRKX(3), RAF1(10), SOS1(10), SOS2(13), SRC(2), TJP1(13), TUBA1A(4), TUBA1B(4), TUBA1C(1), TUBA3C(23), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(12)	53800937	1193	233	1042	604	751	87	78	155	120	2	4.50e-05	1.000	1.000
86	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ADRA1A(9), ADRA1B(4), ADRA1D(5), ADRB1(5), ADRB2(3), ANXA6(5), ARRB1(5), ARRB2(6), ATP1A4(15), ATP1B1(2), ATP1B3(1), ATP2A2(13), ATP2A3(15), ATP2B1(7), ATP2B2(28), ATP2B3(9), CACNA1A(38), CACNA1B(35), CACNA1C(62), CACNA1D(33), CACNA1E(111), CACNA1S(53), CACNB1(4), CACNB3(2), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CASQ1(7), CASQ2(4), CHRM1(5), CHRM2(25), CHRM3(26), CHRM4(6), CHRM5(7), GJA1(9), GJA4(4), GJA5(10), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GNA11(8), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(2), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(6), GRK6(2), ITPR1(36), ITPR2(20), ITPR3(11), KCNB1(38), KCNJ3(20), KCNJ5(13), MIB1(6), NME7(4), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCQ(20), PRKCZ(7), PRKD1(9), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(1), RGS20(2), RGS3(16), RGS4(5), RGS5(4), RGS6(20), RGS7(38), RGS9(14), RYR1(109), RYR2(99), RYR3(90), SLC8A1(34), SLC8A3(43), USP5(7), YWHAB(1), YWHAQ(3)	76057923	1646	231	1556	1093	1131	146	70	120	175	4	0.119	1.000	1.000
87	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(146), CPEB1(10), EGFR(25), ERBB2(9), ERBB4(54), ETS1(4), ETS2(8), ETV6(10), ETV7(5), FMN2(83), GRB2(2), KRAS(5), MAP2K1(14), MAPK1(4), MAPK3(4), NOTCH1(9), NOTCH2(33), NOTCH3(26), NOTCH4(62), PIWIL1(22), PIWIL2(13), PIWIL3(15), PIWIL4(4), RAF1(10), SOS1(10), SOS2(13), SPIRE1(2), SPIRE2(7)	21478846	609	230	459	201	326	28	19	188	46	2	0.000321	1.000	1.000
88	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(5), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ARRB1(5), ARRB2(6), ATF1(4), ATF2(6), ATF3(1), ATF4(9), ATF5(9), ATP2A2(13), ATP2A3(15), CACNB3(2), CALCA(4), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CNN1(6), CNN2(3), CORIN(27), CREB3(1), CRH(3), CRHR1(7), DGKZ(6), ETS2(8), FOS(2), GABPA(5), GABPB2(8), GBA2(2), GJA1(9), GNAQ(6), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(2), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(6), GRK6(2), GSTO1(3), GUCA2A(2), GUCA2B(2), GUCY1A3(32), IGFBP1(4), IGFBP2(2), IGFBP3(2), IGFBP6(2), IL1B(8), IL6(2), ITPR1(36), ITPR2(20), ITPR3(11), JUN(1), MIB1(6), MYL2(9), MYL4(6), MYLK2(12), NFKB1(6), NOS1(74), NOS3(19), OXTR(5), PDE4B(8), PDE4D(7), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PLCD1(4), PLCG1(8), PLCG2(27), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), PRKCD(5), PRKCE(6), PRKCH(9), PRKCQ(20), PRKCZ(7), PRKD1(9), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(1), RGS20(2), RGS3(16), RGS4(5), RGS5(4), RGS6(20), RGS7(38), RGS9(14), RLN1(3), RYR1(109), RYR2(99), RYR3(90), SLC8A1(34), SP1(5), TNXB(128), USP5(7), YWHAB(1), YWHAQ(3)	70961436	1415	228	1341	803	976	116	54	105	161	3	0.000930	1.000	1.000
89	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(5), ACTN2(20), ACTN3(3), ACTN4(5), DES(9), DMD(39), FAM48A(2), MYBPC1(26), MYBPC2(20), MYBPC3(16), MYH3(30), MYH6(37), MYH7(56), MYH8(64), MYL1(12), MYL2(9), MYL3(2), MYL4(6), MYL9(2), MYOM1(24), NEB(129), TNNC2(4), TNNI1(1), TNNI2(2), TNNI3(2), TNNT1(3), TNNT2(5), TNNT3(5), TPM1(4), TPM2(3), TPM3(2), TPM4(3), TTN(1050), VIM(5)	54442253	1609	226	1480	694	1165	111	54	142	122	15	2.23e-07	1.000	1.000
90	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(25), APC2(12), AXIN1(9), AXIN2(4), BTRC(4), CACYBP(2), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CCND1(2), CCND2(6), CCND3(2), CER1(16), CHD8(27), CREBBP(24), CSNK1A1(3), CSNK1A1L(7), CSNK1E(5), CSNK2A1(4), CSNK2A2(1), CSNK2B(2), CTBP2(1), CTNNB1(14), CTNNBIP1(1), CUL1(5), DAAM1(7), DAAM2(7), DKK1(2), DKK2(19), DKK4(3), DVL2(3), DVL3(8), EP300(18), FBXW11(6), FZD1(5), FZD10(4), FZD2(6), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(4), FZD8(5), FZD9(1), GSK3B(3), JUN(1), LEF1(3), LRP5(20), LRP6(29), MAP3K7(1), MAPK10(9), MAPK8(1), MAPK9(3), MMP7(4), MYC(5), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NKD1(8), NKD2(7), NLK(5), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PORCN(4), PPARD(3), PPP2CB(2), PPP2R1A(4), PPP2R1B(3), PPP2R2B(6), PPP2R2C(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRICKLE1(9), PRICKLE2(6), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKX(3), PSEN1(1), RAC1(20), RAC2(3), RHOA(2), ROCK1(7), ROCK2(11), RUVBL1(1), SENP2(14), SFRP1(3), SFRP2(9), SFRP4(5), SFRP5(1), SMAD2(3), SMAD3(4), SMAD4(1), SOX17(8), TBL1X(4), TBL1XR1(1), TBL1Y(9), TCF7(1), TCF7L1(4), TCF7L2(7), TP53(51), VANGL1(3), VANGL2(8), WIF1(7), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(3), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(4), WNT6(3), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(6)	65708312	1018	225	959	461	624	84	44	123	140	3	0.00113	1.000	1.000
91	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(7), CADM1(4), CADM3(19), CD2(27), CD22(23), CD226(6), CD274(1), CD276(7), CD28(2), CD34(4), CD4(8), CD40(4), CD40LG(2), CD58(1), CD6(12), CD80(4), CD86(25), CD8A(2), CD8B(7), CD99(1), CDH1(5), CDH15(8), CDH2(14), CDH4(38), CDH5(11), CLDN1(5), CLDN10(7), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(8), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(1), CLDN3(2), CLDN4(11), CLDN6(8), CLDN7(1), CLDN8(4), CLDN9(1), CNTN1(26), CNTN2(16), CNTNAP1(12), CNTNAP2(88), CTLA4(2), ESAM(5), F11R(7), GLG1(6), HLA-A(3), HLA-C(9), HLA-DMA(7), HLA-DMB(7), HLA-DOA(5), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(12), HLA-DRB5(6), HLA-E(1), HLA-F(4), HLA-G(6), ICAM1(2), ICAM2(4), ICAM3(3), ICOS(2), ICOSLG(2), ITGA4(43), ITGA6(10), ITGA8(37), ITGA9(13), ITGAL(28), ITGAM(23), ITGAV(9), ITGB1(4), ITGB2(16), ITGB7(6), ITGB8(20), JAM2(11), JAM3(3), L1CAM(11), MADCAM1(1), MAG(12), MPZ(3), MPZL1(1), NCAM1(14), NCAM2(10), NEGR1(8), NEO1(13), NFASC(30), NLGN1(12), NLGN2(7), NLGN3(6), NRCAM(10), NRXN1(54), NRXN2(19), NRXN3(32), OCLN(7), PDCD1(4), PDCD1LG2(4), PTPRC(35), PTPRF(32), PTPRM(7), PVR(3), PVRL1(3), PVRL2(6), PVRL3(5), SDC1(3), SDC2(2), SDC3(7), SDC4(3), SELE(33), SELL(10), SELP(39), SELPLG(10), SIGLEC1(32), SPN(5), VCAM1(17), VCAN(42)	59924988	1355	224	1278	638	932	92	49	133	149	0	2.17e-06	1.000	1.000
92	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(4), AKT2(8), AKT3(3), CBL(10), CBLB(21), CBLC(15), CCND1(2), CCND2(6), CCND3(2), CISH(4), CLCF1(1), CNTF(2), CNTFR(4), CREBBP(24), CRLF2(9), CSF2(2), CSF2RA(20), CSF2RB(24), CSF3(4), CSF3R(9), EP300(18), EPO(5), EPOR(1), GH1(3), GH2(10), GHR(40), GRB2(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), IFNAR1(2), IFNAR2(14), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(9), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(3), IL13RA2(5), IL15(3), IL15RA(6), IL19(2), IL2(4), IL20(4), IL20RA(11), IL21(6), IL21R(18), IL22(2), IL22RA1(12), IL22RA2(3), IL23A(2), IL23R(7), IL26(4), IL28A(1), IL28B(5), IL28RA(4), IL29(1), IL2RA(5), IL2RB(12), IL2RG(3), IL3(3), IL3RA(7), IL4(1), IL4R(16), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL6ST(10), IL7(4), IL7R(34), IL9(1), IL9R(6), IRF9(2), JAK1(6), JAK2(8), JAK3(11), LEP(4), LEPR(29), LIF(1), LIFR(39), MPL(8), MYC(5), OSM(5), OSMR(39), PIAS1(5), PIAS2(5), PIAS3(6), PIAS4(1), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PIM1(1), PRL(3), PRLR(35), PTPN11(10), PTPN6(5), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SOCS5(8), SOCS7(5), SOS1(10), SOS2(13), SPRED1(5), SPRED2(4), SPRY1(9), SPRY2(4), SPRY3(12), SPRY4(2), STAM(3), STAM2(3), STAT1(5), STAT2(6), STAT3(9), STAT4(26), STAT5A(3), STAT5B(6), STAT6(8), TPO(47), TSLP(2), TYK2(8)	59512047	1134	224	1087	525	744	92	37	117	142	2	0.00232	1.000	1.000
93	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(6), ADORA2A(3), ADORA2B(1), ADORA3(15), ADRA1A(9), ADRA1B(4), ADRA1D(5), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(3), AGTR1(10), AGTR2(9), AVPR1A(4), AVPR1B(11), BDKRB1(6), BDKRB2(9), BRS3(5), C3AR1(5), CCBP2(10), CCKAR(11), CCKBR(11), CCR1(10), CCR10(3), CCR2(17), CCR3(10), CCR4(9), CCR5(10), CCR6(3), CCR7(4), CCR8(8), CCR9(5), CCRL2(6), CHML(5), CHRM1(5), CHRM2(25), CHRM3(26), CHRM4(6), CHRM5(7), CMKLR1(15), CNR1(13), CNR2(5), CX3CR1(17), CXCR3(4), CXCR4(3), DRD1(9), DRD2(14), DRD3(6), DRD4(1), DRD5(25), EDNRA(10), EDNRB(7), F2R(8), F2RL1(16), F2RL2(8), F2RL3(4), FPR1(21), FSHR(19), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(3), GPR35(6), GPR37(9), GPR37L1(7), GPR4(4), GPR50(19), GPR6(7), GPR63(9), GPR77(6), GPR83(13), GPR85(5), GPR87(6), GRPR(7), HCRTR1(2), HCRTR2(33), HRH1(14), HRH2(3), HRH3(5), HTR1A(10), HTR1B(1), HTR1D(6), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(13), HTR4(9), HTR5A(19), HTR6(1), HTR7(9), LHCGR(27), LTB4R(1), MAS1(4), MC3R(7), MC4R(1), MC5R(8), MLNR(1), MTNR1A(10), MTNR1B(8), NMBR(7), NMUR1(8), NMUR2(16), NPY1R(29), NPY2R(13), NPY5R(24), NTSR1(7), NTSR2(2), OPN1SW(3), OPN3(4), OPRD1(3), OPRK1(24), OPRL1(8), OPRM1(5), OR10A5(9), OR11A1(6), OR12D3(9), OR1C1(13), OR1F1(8), OR1Q1(6), OR2H1(9), OR5V1(12), OR7A5(2), OR7C1(2), OR8B8(14), OXTR(5), P2RY1(5), P2RY10(7), P2RY12(4), P2RY13(4), P2RY14(8), P2RY2(8), P2RY6(2), PPYR1(14), PTAFR(2), PTGDR(11), PTGER2(7), PTGER4(2), PTGFR(21), PTGIR(5), RGR(5), RHO(2), RRH(2), SSTR1(10), SSTR2(7), SSTR3(11), SSTR4(4), SUCNR1(11), TBXA2R(4), TRHR(23)	49610875	1300	223	1213	970	875	135	47	143	100	0	0.000855	1.000	1.000
94	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(6), BRAF(146), CHUK(2), DAXX(9), ELK1(3), FOS(2), GRB2(2), HRAS(3), IKBKB(4), JUN(1), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP2K5(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K10(9), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K14(6), MAP3K2(6), MAP3K3(8), MAP3K4(17), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP3K9(26), MAP4K1(11), MAP4K2(7), MAP4K3(11), MAP4K4(16), MAP4K5(4), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK4(18), MAPK6(7), MAPK7(4), MAPK8(1), MAPK9(3), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), MKNK1(6), MKNK2(3), MYC(5), NFKB1(6), NFKBIA(2), PAK1(4), PAK2(7), RAC1(20), RAF1(10), RELA(4), RIPK1(3), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA4(4), RPS6KA5(7), RPS6KB1(3), RPS6KB2(2), SHC1(2), SP1(5), STAT1(5), TGFB1(2), TGFB2(3), TGFB3(3), TRAF2(2)	38638042	610	223	455	220	294	47	28	187	54	0	0.00135	1.000	1.000
95	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ASIP(2), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CREB3(1), CREB3L1(5), CREB3L2(9), CREB3L3(10), CREB3L4(7), CREBBP(24), CTNNB1(14), DCT(4), DVL2(3), DVL3(8), EDN1(9), EDNRB(7), EP300(18), FZD1(5), FZD10(4), FZD2(6), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(4), FZD8(5), FZD9(1), GNAI1(2), GNAI2(6), GNAI3(2), GNAO1(2), GNAQ(6), GNAS(25), GSK3B(3), HRAS(3), KIT(12), KITLG(11), KRAS(5), LEF1(3), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MITF(6), NRAS(86), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), POMC(4), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCG(16), PRKX(3), RAF1(10), TCF7(1), TCF7L1(4), TCF7L2(7), TYR(9), TYRP1(10), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(3), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(4), WNT6(3), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(6)	44219924	893	222	766	433	503	78	75	139	96	2	0.000552	1.000	1.000
96	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(4), AKT2(8), AKT3(3), BRAF(146), DAG1(9), DRD2(14), EGFR(25), EPHB2(34), GRB2(2), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), KCNJ3(20), KCNJ5(13), KCNJ9(6), MAPK1(4), PI3(6), PIK3CB(14), PITX2(5), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), RAF1(10), RGS20(2), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT3(9), TERF2IP(1)	23917225	596	221	434	242	314	38	27	165	50	2	0.000590	1.000	1.000
97	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ATF4(9), CACNA1C(62), CACNA1D(33), CACNA1F(23), CACNA1S(53), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CDC42(2), CGA(1), EGFR(25), ELK1(3), FSHB(8), GNA11(8), GNAQ(6), GNAS(25), GNRH2(2), GNRHR(2), GRB2(2), HBEGF(1), HRAS(3), ITPR1(36), ITPR2(20), ITPR3(11), JUN(1), KRAS(5), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K2(6), MAP3K3(8), MAP3K4(17), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK7(4), MAPK8(1), MAPK9(3), MMP14(3), MMP2(8), NRAS(86), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLD1(13), PLD2(8), PRKACA(3), PRKACB(4), PRKACG(11), PRKCA(8), PRKCD(5), PRKX(3), PTK2B(10), RAF1(10), SOS1(10), SOS2(13), SRC(2)	51550858	1065	219	930	586	632	91	79	143	116	4	0.0246	1.000	1.000
98	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(2), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), ADK(4), ADSL(5), ADSS(1), ADSSL1(7), AK1(1), AK2(3), AK5(10), AK7(26), ALLC(6), AMPD1(34), AMPD2(7), AMPD3(25), APRT(3), ATIC(5), CANT1(10), DGUOK(4), ENPP1(13), ENPP3(13), ENTPD1(12), ENTPD2(4), ENTPD3(9), ENTPD4(4), ENTPD5(2), ENTPD6(4), ENTPD8(2), FHIT(2), GART(11), GDA(16), GMPR(2), GMPR2(1), GMPS(6), GUCY1A2(21), GUCY1A3(32), GUCY1B3(7), GUCY2C(38), GUCY2D(9), GUCY2F(23), GUK1(3), IMPDH1(4), IMPDH2(1), ITPA(1), NME4(1), NME6(3), NME7(4), NPR1(18), NPR2(20), NT5C1A(6), NT5C2(3), NT5C3(2), NT5E(6), NT5M(2), NUDT2(1), NUDT5(1), NUDT9(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE10A(12), PDE11A(20), PDE1A(43), PDE1C(52), PDE2A(16), PDE3B(6), PDE4A(11), PDE4B(8), PDE4C(19), PDE4D(7), PDE5A(10), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(16), PDE8A(3), PDE8B(22), PDE9A(11), PFAS(12), PKLR(13), PKM2(7), PNPT1(3), POLA1(3), POLA2(8), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3A(7), POLR3B(14), POLR3G(1), POLR3GL(2), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(21), PRPS1(2), PRPS1L1(13), PRPS2(2), PRUNE(3), RRM1(3), RRM2(3), RRM2B(2), XDH(59)	66791591	1162	216	1100	566	797	94	52	104	115	0	4.62e-05	1.000	1.000
99	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(31), BDKRB1(6), BDKRB2(9), C1QA(6), C1QB(7), C1QC(10), C1R(16), C1S(20), C3(48), C3AR1(5), C4BPA(16), C4BPB(6), C5(21), C5AR1(10), C6(72), C7(47), C8A(43), C8B(46), C8G(1), C9(22), CD55(6), CD59(1), CFB(55), CFH(80), CFI(18), CPB2(1), CR1(56), CR2(34), F10(7), F11(12), F12(1), F13A1(27), F13B(32), F2(11), F2R(8), F3(2), F5(36), F7(7), F8(49), F9(15), FGA(41), FGB(10), FGG(10), KLKB1(27), KNG1(14), MASP1(10), MASP2(11), MBL2(13), PLAT(4), PLAU(3), PLAUR(3), PLG(34), PROC(12), PROS1(18), SERPINA1(8), SERPINA5(10), SERPINC1(8), SERPIND1(5), SERPINE1(5), SERPINF2(7), SERPING1(13), TFPI(7), THBD(3), VWF(56)	36946360	1232	216	1140	492	868	81	48	115	117	3	1.70e-07	1.000	1.000
100	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADCY9(10), AKAP1(10), AKAP10(2), AKAP11(13), AKAP12(6), AKAP3(17), AKAP4(19), AKAP6(39), AKAP7(2), AKAP8(7), AKAP9(34), ARHGEF1(1), CALM1(1), CALM2(1), CHMP1B(1), GNA11(8), GNA12(3), GNA13(1), GNA14(6), GNA15(6), GNAI2(6), GNAI3(2), GNAL(2), GNAO1(2), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB5(2), GNG4(3), GNG7(2), GNGT2(5), HRAS(3), ITPR1(36), KCNJ3(20), KRAS(5), NRAS(86), PDE1A(43), PDE1B(16), PDE1C(52), PDE4A(11), PDE4B(8), PDE4C(19), PDE4D(7), PDE7A(1), PDE7B(16), PDE8A(3), PDE8B(22), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(20), PRKCZ(7), PRKD1(9), PRKD3(6), RHOA(2), RRAS(1), SLC9A1(5), USP5(7)	47784901	878	213	768	453	540	64	69	123	82	0	0.0349	1.000	1.000
101	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(4), AKT2(8), AKT3(3), BCL10(3), CARD11(38), CBL(10), CBLB(21), CBLC(15), CD247(4), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(8), CD40LG(2), CD8A(2), CD8B(7), CDC42(2), CDK4(7), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(7), GRAP2(5), GRB2(2), HRAS(3), ICOS(2), IFNG(4), IKBKB(4), IL10(3), IL2(4), IL4(1), IL5(4), ITK(24), JUN(1), KRAS(5), LAT(2), LCK(15), LCP2(9), MALT1(8), MAP3K14(6), NCK1(2), NCK2(4), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NRAS(86), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDCD1(4), PDK1(2), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRKCQ(20), PTPN6(5), PTPRC(35), RASGRP1(11), RHOA(2), SOS1(10), SOS2(13), TEC(13), TNF(1), VAV1(19), VAV2(3), VAV3(14), ZAP70(7)	41487617	785	211	674	320	440	56	63	132	93	1	0.000674	1.000	1.000
102	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(4), ATF1(4), BRAF(146), CAMP(2), CREB3(1), CREB5(9), CREBBP(24), CRKL(3), DAG1(9), EGR1(4), EGR2(5), EGR3(4), EGR4(5), ELK1(3), FRS2(7), GNAQ(6), JUN(1), MAP1B(25), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK3(4), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3), NTRK1(16), OPN1LW(8), PIK3C2G(53), PIK3CA(10), PIK3CD(8), PIK3R1(2), PTPN11(10), RPS6KA3(1), SHC1(2), SRC(2), TERF2IP(1), TH(12)	20929505	441	211	295	155	208	27	18	156	31	1	0.00476	1.000	1.000
103	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(18), AMY2A(6), AMY2B(13), ASCC3(13), ATP13A2(12), DDX18(5), DDX23(6), DDX4(12), DDX41(7), DDX47(1), DDX50(4), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHX58(4), ENPP1(13), ENPP3(13), ENTPD7(2), EP400(27), ERCC2(3), ERCC3(6), G6PC(5), G6PC2(4), GAA(8), GANC(7), GBA(7), GBA3(19), GBE1(9), GCK(17), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(13), HK3(14), IFIH1(12), MGAM(162), MOV10L1(25), NUDT5(1), NUDT8(2), PGM1(6), PGM3(1), PYGB(3), PYGL(9), PYGM(12), RAD54B(8), RUVBL2(5), SETX(19), SI(87), SKIV2L2(6), SMARCA2(14), SMARCA5(5), TREH(4), UGDH(1), UGP2(1), UGT1A1(77), UGT2A1(35), UGT2A3(28), UGT2B10(45), UGT2B11(23), UGT2B15(31), UGT2B17(29), UGT2B28(26), UGT2B4(34), UGT2B7(19), UXS1(4)	50269483	1057	210	973	435	730	82	36	78	130	1	1.94e-07	1.000	1.000
104	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALM2(1), CALML3(9), CALML6(1), CDS1(11), CDS2(5), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKI(31), DGKQ(7), DGKZ(6), IMPA1(1), IMPA2(4), INPP1(3), INPP4A(7), INPP4B(2), INPP5A(4), INPP5B(6), INPP5D(37), INPPL1(16), ITGB1BP3(1), ITPK1(5), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), OCRL(6), PI4KA(21), PI4KB(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(53), PIK3C3(3), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLCD1(4), PLCD3(4), PLCD4(4), PLCE1(57), PLCG1(8), PLCG2(27), PLCZ1(30), PRKCA(8), PRKCG(16), PTEN(23), SYNJ1(20), SYNJ2(22)	50604336	941	210	867	425	640	46	41	85	126	3	4.71e-06	1.000	1.000
105	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(24), CD14(5), CD19(8), CD1A(14), CD1B(13), CD1C(27), CD1D(10), CD1E(26), CD2(27), CD22(23), CD33(21), CD34(4), CD36(6), CD37(3), CD38(6), CD3D(7), CD3E(2), CD3G(1), CD4(8), CD44(5), CD5(7), CD55(6), CD59(1), CD7(1), CD8A(2), CD8B(7), CD9(2), CR1(56), CR2(34), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(20), CSF3(4), CSF3R(9), DNTT(10), EPO(5), EPOR(1), FCER2(2), FCGR1A(9), FLT3(35), FLT3LG(1), GP5(7), GP9(6), GYPA(16), HLA-DRA(12), HLA-DRB5(6), IL11(3), IL11RA(3), IL1A(5), IL1B(8), IL1R1(13), IL1R2(8), IL2RA(5), IL3(3), IL3RA(7), IL4(1), IL4R(16), IL5(4), IL5RA(17), IL6(2), IL6R(3), IL7(4), IL7R(34), IL9R(6), ITGA1(24), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGAM(23), ITGB3(15), KIT(12), KITLG(11), MME(23), MS4A1(7), TFRC(4), THPO(9), TNF(1), TPO(47)	33265877	955	210	889	446	669	51	33	74	126	2	0.000653	1.000	1.000
106	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(4), AKT2(8), AKT3(3), BCL10(3), BLNK(15), BTK(16), CARD11(38), CD19(8), CD22(23), CD72(5), CD79A(3), CD81(2), CHUK(2), CR2(34), FCGR2B(4), FOS(2), GSK3B(3), HRAS(3), IKBKB(4), INPP5D(37), JUN(1), KRAS(5), LILRB3(28), LYN(10), MALT1(8), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NRAS(86), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLCG2(27), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PTPN6(5), RAC1(20), RAC2(3), RASGRP3(12), SYK(14), VAV1(19), VAV2(3), VAV3(14)	30481292	645	210	537	241	360	36	61	109	77	2	4.15e-06	1.000	1.000
107	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(13), ANAPC1(17), ANAPC10(1), ANAPC2(6), ANAPC4(6), ANAPC5(10), ANAPC7(6), ATM(15), ATR(23), BUB1(6), BUB1B(10), BUB3(1), CCNA1(14), CCNB2(2), CCNB3(31), CCND1(2), CCND2(6), CCND3(2), CCNE1(4), CCNE2(8), CCNH(2), CDC14A(6), CDC14B(3), CDC16(1), CDC20(1), CDC23(4), CDC25A(8), CDC25B(4), CDC25C(5), CDC27(13), CDC6(2), CDC7(2), CDK4(7), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2A(42), CDKN2C(1), CHEK1(2), CHEK2(2), CREBBP(24), CUL1(5), DBF4(6), E2F1(5), E2F2(5), E2F3(5), EP300(18), ESPL1(20), FZR1(7), GADD45B(2), GSK3B(3), HDAC1(2), HDAC2(2), MAD1L1(6), MAD2L1(1), MAD2L2(1), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(1), PCNA(2), PKMYT1(3), PLK1(4), PRKDC(19), PTTG1(1), PTTG2(4), RB1(10), RBL1(12), RBL2(6), SKP2(2), SMAD2(3), SMAD3(4), SMAD4(1), SMC1A(3), SMC1B(23), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3), TP53(51), WEE1(2), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	55803689	616	208	570	212	331	48	39	88	107	3	8.83e-06	1.000	1.000
108	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(8), ACTN2(20), ACTN3(3), ACTN4(5), ARHGAP5(13), BCAR1(5), CD99(1), CDC42(2), CDH5(11), CLDN1(5), CLDN10(7), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(8), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(1), CLDN3(2), CLDN4(11), CLDN6(8), CLDN7(1), CLDN8(4), CLDN9(1), CTNNA1(3), CTNNA2(30), CTNNA3(38), CTNNB1(14), CTNND1(8), CXCL12(3), CXCR4(3), CYBA(1), CYBB(8), ESAM(5), EZR(5), F11R(7), GNAI1(2), GNAI2(6), GNAI3(2), ICAM1(2), ITGA4(43), ITGAL(28), ITGAM(23), ITGB1(4), ITGB2(16), ITK(24), JAM2(11), JAM3(3), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MLLT4(16), MMP2(8), MMP9(7), MSN(2), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLPF(2), NCF1(3), NCF2(9), NCF4(5), NOX1(13), NOX3(7), OCLN(7), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLCG1(8), PLCG2(27), PRKCA(8), PRKCG(16), PTK2(7), PTK2B(10), PTPN11(10), PXN(2), RAC1(20), RAC2(3), RAP1A(2), RAP1B(1), RAPGEF3(14), RAPGEF4(17), RASSF5(4), RHOA(2), RHOH(6), ROCK1(7), ROCK2(11), SIPA1(8), THY1(1), TXK(10), VASP(3), VAV1(19), VAV2(3), VAV3(14), VCAM1(17), VCL(8)	50555380	885	207	829	428	579	64	28	97	114	3	0.000244	1.000	1.000
109	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(4), AKT3(3), BCAR1(5), CAPN1(4), CAPN10(7), CAPN11(10), CAPN2(5), CAPN3(9), CAPN5(4), CAPN6(16), CAPN7(1), CAPN9(12), CAPNS1(3), CAV1(1), CAV3(2), CDC42(2), CRK(3), CSK(1), DOCK1(17), FYN(7), GIT2(8), GRB2(2), ILK(2), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(43), ITGA5(25), ITGA6(10), ITGA7(25), ITGA8(37), ITGA9(13), ITGAD(30), ITGAE(21), ITGAL(28), ITGAM(23), ITGAV(9), ITGAX(23), ITGB1(4), ITGB2(16), ITGB3(15), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(6), ITGB8(20), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K6(3), MAPK10(9), MAPK12(1), MAPK4(18), MAPK6(7), MAPK7(4), MYLK2(12), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PDPK1(3), PIK3R2(5), PTK2(7), PXN(2), RAC1(20), RAC2(3), RAP1B(1), RAPGEF1(12), RHO(2), ROCK1(7), ROCK2(11), SDCCAG8(3), SEPP1(11), SHC1(2), SHC3(14), SORBS1(15), SOS1(10), SRC(2), TLN1(12), TNS1(8), VASP(3), VAV2(3), VAV3(14), VCL(8), ZYX(8)	54316275	884	207	838	422	585	64	32	105	96	2	0.00161	1.000	1.000
110	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(15), ABCA10(23), ABCA12(78), ABCA13(76), ABCA2(15), ABCA3(17), ABCA4(56), ABCA5(12), ABCA6(28), ABCA7(18), ABCA8(37), ABCA9(23), ABCB1(39), ABCB10(7), ABCB11(49), ABCB4(21), ABCB5(51), ABCB6(2), ABCB7(5), ABCB8(3), ABCB9(6), ABCC1(15), ABCC10(16), ABCC11(19), ABCC12(25), ABCC2(11), ABCC3(29), ABCC4(14), ABCC5(11), ABCC6(30), ABCC8(44), ABCC9(59), ABCD2(17), ABCD3(9), ABCD4(3), ABCG1(12), ABCG2(6), ABCG4(7), ABCG5(5), ABCG8(15), CFTR(60), TAP1(2), TAP2(14)	48150528	1004	206	944	560	661	76	34	108	123	2	0.00174	1.000	1.000
111	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(4), AKT2(8), AKT3(3), BRAF(146), CAB39(1), EIF4B(5), EIF4EBP1(1), FIGF(5), HIF1A(4), IGF1(10), MAPK1(4), MAPK3(4), PDPK1(3), PGF(1), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PRKAA1(1), PRKAA2(30), RHEB(1), RICTOR(12), RPS6(1), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA6(19), RPS6KB1(3), RPS6KB2(2), STK11(4), TSC1(9), TSC2(12), ULK1(9), ULK2(7), ULK3(1), VEGFA(4), VEGFB(2), VEGFC(23)	21573762	438	206	292	137	192	24	18	159	43	2	0.000210	1.000	1.000
112	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(4), APC(25), AR(10), BRAF(146), CAMP(2), CCL15(3), CCL16(2), DAG1(9), EGFR(25), GNA11(8), GNA15(6), GNAI1(2), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), KCNJ3(20), KCNJ5(13), KCNJ9(6), MAPK1(4), MAPK10(9), MAPK14(5), PHKA2(9), PIK3CA(10), PIK3CD(8), PIK3R1(2), PITX2(5), PTX3(1), RAF1(10), SRC(2)	21741923	430	205	292	166	190	23	22	157	37	1	0.0166	1.000	1.000
113	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1C2(3), AKR1C3(14), AKR1C4(10), ALDH1A3(2), ALDH3A1(8), ALDH3B1(3), ALDH3B2(8), CYP1A1(9), CYP1A2(8), CYP1B1(4), CYP2B6(21), CYP2C19(75), CYP2C8(32), CYP2C9(38), CYP2E1(13), CYP2F1(12), CYP2S1(14), CYP3A4(20), CYP3A43(19), CYP3A7(30), DHDH(5), EPHX1(2), GSTA1(6), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(3), GSTM1(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), MGST1(2), MGST2(2), MGST3(1), UGT1A1(77), UGT2A1(35), UGT2A3(28), UGT2B10(45), UGT2B11(23), UGT2B15(31), UGT2B17(29), UGT2B28(26), UGT2B4(34), UGT2B7(19)	23423593	836	203	756	335	600	51	31	49	103	2	9.93e-13	1.000	1.000
114	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(9), ALG1(3), ALG10(6), ALG10B(4), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG6(2), ALG8(7), ALG9(6), B3GNT1(3), B3GNT2(2), B3GNT6(1), B3GNT7(6), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT5(2), C1GALT1(6), C1GALT1C1(3), CHPF(4), CHST1(10), CHST11(7), CHST12(5), CHST13(3), CHST14(3), CHST2(5), CHST3(2), CHST4(10), CHST6(4), CHST7(3), CHSY1(8), DAD1(1), DDOST(2), DPAGT1(2), EXT1(2), EXT2(8), EXTL1(2), EXTL3(12), FUT11(4), FUT8(8), GALNT1(4), GALNT10(7), GALNT11(2), GALNT12(8), GALNT13(29), GALNT14(24), GALNT2(6), GALNT3(4), GALNT4(5), GALNT5(13), GALNT6(17), GALNT7(4), GALNT8(27), GALNT9(7), GALNTL1(6), GALNTL2(22), GALNTL4(10), GALNTL5(18), GANAB(5), GCNT1(6), GCNT3(7), GCNT4(4), HS2ST1(1), HS3ST1(10), HS3ST2(9), HS3ST3A1(6), HS3ST3B1(2), HS3ST5(8), HS6ST1(2), HS6ST2(3), HS6ST3(15), MAN1A1(18), MAN1A2(7), MAN1B1(3), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(2), MGAT3(11), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(12), NDST1(6), NDST2(2), NDST3(25), NDST4(52), OGT(10), RPN2(4), ST3GAL1(7), ST3GAL2(1), ST3GAL3(2), ST3GAL4(2), ST6GAL1(6), ST6GALNAC1(8), STT3B(5), WBSCR17(44), XYLT1(12), XYLT2(4)	44850098	769	201	735	399	498	60	31	85	95	0	0.0207	1.000	1.000
115	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(4), AKT2(8), AKT3(3), BTK(16), CSF2(2), FCER1A(15), FCER1G(1), FYN(7), GAB2(4), GRB2(2), HRAS(3), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(37), KRAS(5), LAT(2), LCP2(9), LYN(10), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK8(1), MAPK9(3), MS4A2(13), NRAS(86), PDK1(2), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLCG1(8), PLCG2(27), PRKCA(8), PRKCD(5), PRKCE(6), RAC1(20), RAC2(3), RAF1(10), SOS1(10), SOS2(13), SYK(14), TNF(1), VAV1(19), VAV2(3), VAV3(14)	29519234	625	201	510	216	338	37	52	114	82	2	8.28e-08	1.000	1.000
116	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(4), ACTB(8), ACTG1(6), ACTN1(8), ACTN2(20), ACTN3(3), ACTN4(5), ACVR1B(3), ACVR1C(10), BAIAP2(7), CDC42(2), CDH1(5), CREBBP(24), CSNK2A1(4), CSNK2A2(1), CSNK2B(2), CTNNA1(3), CTNNA2(30), CTNNA3(38), CTNNB1(14), CTNND1(8), EGFR(25), EP300(18), ERBB2(9), FARP2(4), FER(3), FGFR1(11), FYN(7), IGF1R(14), INSR(26), IQGAP1(9), LEF1(3), LMO7(29), MAP3K7(1), MAPK1(4), MAPK3(4), MET(23), MLLT4(16), NLK(5), PARD3(18), PTPN1(4), PTPN6(5), PTPRB(89), PTPRF(32), PTPRJ(9), PTPRM(7), PVRL1(3), PVRL2(6), PVRL3(5), PVRL4(10), RAC1(20), RAC2(3), RHOA(2), SMAD2(3), SMAD3(4), SMAD4(1), SNAI1(2), SNAI2(3), SORBS1(15), SRC(2), SSX2IP(4), TCF7(1), TCF7L1(4), TCF7L2(7), TGFBR2(9), TJP1(13), VCL(8), WAS(8), WASF1(4), WASF2(5), WASF3(13), WASL(5), YES1(4)	49153302	744	198	695	347	491	56	28	78	88	3	0.0226	1.000	1.000
117	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(4), AKT2(8), AKT3(3), CASP8(9), CD14(5), CD40(4), CD80(4), CD86(25), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(3), FOS(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), IFNAR1(2), IFNAR2(14), IFNB1(6), IKBKB(4), IKBKE(10), IL12A(4), IL12B(3), IL1B(8), IL6(2), IL8(1), IRAK1(5), IRAK4(3), IRF3(3), IRF5(5), IRF7(5), JUN(1), LBP(9), LY96(4), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K7(1), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK8(1), MAPK9(3), MYD88(3), NFKB1(6), NFKB2(3), NFKBIA(2), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), RAC1(20), RELA(4), RIPK1(3), SPP1(7), STAT1(5), TBK1(4), TICAM1(9), TIRAP(1), TLR1(15), TLR2(15), TLR3(11), TLR4(41), TLR5(22), TLR6(7), TLR7(17), TLR8(14), TLR9(18), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4)	36651853	606	198	566	275	395	38	30	77	65	1	0.000501	1.000	1.000
118	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(4), AKT2(8), AKT3(3), CASP9(2), CDC42(2), HRAS(3), KDR(55), KRAS(5), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPKAPK2(5), MAPKAPK3(5), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NOS3(19), NRAS(86), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLCG1(8), PLCG2(27), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRKCA(8), PRKCG(16), PTGS2(13), PTK2(7), PXN(2), RAC1(20), RAC2(3), RAF1(10), SH2D2A(4), SHC2(6), SPHK1(2), SPHK2(7), SRC(2), VEGFA(4)	29506241	605	196	495	215	341	32	49	113	68	2	2.66e-07	1.000	1.000
119	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(11), ADCY8(55), ADK(4), ADSL(5), ADSS(1), AK1(1), AK2(3), AK5(10), ALLC(6), AMPD1(34), AMPD2(7), AMPD3(25), APRT(3), ATIC(5), ATP1B1(2), ATP5A1(1), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(3), ATP5H(3), ATP5J(2), CANT1(10), DGUOK(4), ENPP1(13), ENPP3(13), ENTPD1(12), ENTPD2(4), FHIT(2), GART(11), GDA(16), GMPS(6), GUCY1A2(21), GUCY1A3(32), GUCY1B3(7), GUCY2C(38), GUCY2D(9), GUCY2F(23), GUK1(3), IMPDH1(4), IMPDH2(1), ITPA(1), NPR1(18), NPR2(20), NT5E(6), NT5M(2), NUDT2(1), PAICS(1), PAPSS1(4), PAPSS2(5), PDE1A(43), PDE4A(11), PDE4B(8), PDE4C(19), PDE4D(7), PDE5A(10), PDE6B(16), PDE6C(24), PDE6G(2), PDE7B(16), PDE8A(3), PDE9A(11), PFAS(12), PKLR(13), PKM2(7), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(9), POLL(8), POLQ(25), POLR1B(9), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLRMT(3), PRPS1(2), PRPS1L1(13), PRPS2(2), PRUNE(3), RRM1(3), RRM2(3)	52312939	903	191	848	449	618	71	32	86	96	0	0.000230	1.000	1.000
120	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(13), ATM(15), BUB1(6), BUB1B(10), BUB3(1), CCNA1(14), CCNB2(2), CCNB3(31), CCND2(6), CCND3(2), CCNE1(4), CCNE2(8), CCNH(2), CDAN1(6), CDC14A(6), CDC14B(3), CDC20(1), CDC25A(8), CDC25B(4), CDC25C(5), CDC6(2), CDC7(2), CDH1(5), CDK4(7), CDKN1A(3), CDKN2A(42), CHEK1(2), CHEK2(2), DTX4(4), E2F1(5), E2F2(5), E2F3(5), E2F4(3), E2F5(3), E2F6(1), EP300(18), ESPL1(20), GSK3B(3), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(2), HDAC8(5), MAD1L1(6), MAD2L1(1), MAD2L2(1), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(1), MPEG1(6), MPL(8), PCNA(2), PLK1(4), PRKDC(19), PTPRA(9), PTTG1(1), PTTG2(4), RB1(10), RBL1(12), SKP2(2), SMAD4(1), TBC1D8(10), TFDP1(2), TGFB1(2), TP53(51), WEE1(2)	44886756	505	189	463	188	280	44	26	62	90	3	8.09e-05	1.000	1.000
121	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(64), COL4A2(35), COL4A3(44), COL4A4(114), COL4A5(68), COL4A6(42), F10(7), F11(12), F12(1), F2(11), F2R(8), F5(36), F8(49), F9(15), FGA(41), FGB(10), FGG(10), KLKB1(27), PROC(12), PROS1(18), SERPINC1(8), SERPING1(13)	18160844	645	188	600	176	473	40	20	56	55	1	0.000825	1.000	1.000
122	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(18), AMY2A(6), AMY2B(13), ENPP1(13), ENPP3(13), G6PC(5), GAA(8), GANAB(5), GBA3(19), GBE1(9), GCK(17), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(13), HK3(14), MGAM(162), PGM1(6), PGM3(1), PYGB(3), PYGL(9), PYGM(12), SI(87), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(77), UGT2B15(31), UGT2B4(34), UXS1(4)	23197872	625	188	569	257	442	59	20	39	64	1	6.33e-06	1.000	1.000
123	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(2), ACVR1B(3), ACVR1C(10), ACVR2A(4), ACVR2B(3), ACVRL1(11), AMHR2(16), BMP2(7), BMP4(4), BMP5(32), BMP6(12), BMP7(5), BMP8A(2), BMPR1A(2), BMPR1B(4), BMPR2(6), CHRD(21), COMP(8), CREBBP(24), CUL1(5), DCN(18), E2F4(3), E2F5(3), EP300(18), FST(5), GDF5(16), GDF6(2), GDF7(2), ID1(1), ID2(2), IFNG(4), INHBA(19), INHBB(9), INHBC(12), INHBE(5), LEFTY1(6), LEFTY2(3), LTBP1(45), MAPK1(4), MAPK3(4), MYC(5), NODAL(2), NOG(2), PITX2(5), PPP2CB(2), PPP2R1A(4), PPP2R1B(3), PPP2R2B(6), PPP2R2C(8), RBL1(12), RBL2(6), RHOA(2), ROCK1(7), ROCK2(11), RPS6KB1(3), RPS6KB2(2), SMAD1(5), SMAD2(3), SMAD3(4), SMAD4(1), SMAD5(3), SMAD6(7), SMAD7(1), SMAD9(11), SMURF1(2), SMURF2(9), SP1(5), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), THBS1(30), THBS2(12), THBS3(11), THBS4(19), TNF(1), ZFYVE16(5), ZFYVE9(9)	40610484	599	187	572	259	381	55	27	59	77	0	0.00949	1.000	1.000
124	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(10), AGTR2(9), ATP8A1(28), AVPR1A(4), AVPR1B(11), BDKRB1(6), BDKRB2(9), BRS3(5), C3AR1(5), CCKAR(11), CCKBR(11), CCR1(10), CCR10(3), CCR2(17), CCR3(10), CCR4(9), CCR5(10), CCR6(3), CCR7(4), CCR8(8), CX3CR1(17), CXCR3(4), CXCR4(3), CXCR6(4), EDNRA(10), EDNRB(7), FPR1(21), FSHR(19), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GNRHR(2), GPR77(6), GRPR(7), LHCGR(27), MC2R(5), MC3R(7), MC4R(1), MC5R(8), NMBR(7), NPY1R(29), NPY2R(13), NPY5R(24), NTSR1(7), NTSR2(2), OPRD1(3), OPRK1(24), OPRL1(8), OPRM1(5), OXTR(5), PPYR1(14), SSTR1(10), SSTR2(7), SSTR3(11), SSTR4(4), TACR1(8), TACR2(7), TACR3(27), TRHR(23), TSHR(8)	21450347	601	186	562	410	416	56	27	55	47	0	0.000722	1.000	1.000
125	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(2), ACVR1B(3), ACVRL1(11), AKT1(4), AURKB(2), BMPR1A(2), BMPR2(6), BUB1(6), CDKL1(5), CDKL2(2), CDS1(11), CDS2(5), CLK1(5), CLK2(8), COL4A3BP(3), CSNK2A1(4), CSNK2A2(1), CSNK2B(2), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKQ(7), DGKZ(6), IMPA1(1), INPP1(3), INPP4A(7), INPP4B(2), INPP5A(4), INPPL1(16), ITPKB(11), MAP3K10(9), MOS(6), NEK1(7), NEK3(2), OCRL(6), PAK4(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(53), PIK3CA(10), PIK3CB(14), PIK3CG(27), PIM2(4), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLCD1(4), PLCG1(8), PLCG2(27), PLK3(3), PRKACA(3), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCQ(20), PRKCZ(7), PRKD1(9), PRKG1(14), RAF1(10), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA4(4), RPS6KB1(3), STK11(4), VRK1(1)	45921893	749	186	698	399	511	42	27	71	96	2	0.281	1.000	1.000
126	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), IMPA2(4), INPP1(3), INPP4A(7), INPP4B(2), INPP5A(4), INPP5B(6), INPPL1(16), IPMK(2), ISYNA1(1), ITGB1BP3(1), ITPK1(5), ITPKB(11), MINPP1(1), MIOX(4), OCRL(6), PI4KA(21), PI4KB(8), PIK3C3(3), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLCD1(4), PLCD3(4), PLCD4(4), PLCE1(57), PLCG1(8), PLCG2(27), PLCZ1(30), PTEN(23), SYNJ1(20), SYNJ2(22)	30187865	567	184	530	244	370	25	29	61	80	2	0.000108	1.000	1.000
127	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AGK(8), AGPAT1(1), AGPAT2(2), AGPAT3(6), AGPAT4(6), AGPAT6(3), AKR1A1(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), CEL(13), DAK(3), DGAT1(1), DGAT2(7), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKI(31), DGKQ(7), DGKZ(6), GK(9), GK2(38), GLA(2), GLB1(9), GPAM(7), LCT(51), LIPA(5), LIPC(10), LIPF(18), LIPG(8), LPL(6), MGLL(8), PNLIP(9), PNLIPRP1(10), PNLIPRP2(3), PNPLA3(3), PPAP2A(1), PPAP2B(11), PPAP2C(8)	24043462	534	183	485	215	359	45	21	52	57	0	5.15e-07	1.000	1.000
128	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(4), BRAF(146), CREB3(1), CREB5(9), DUSP4(2), DUSP6(2), DUSP9(3), EEF2K(6), GRB2(2), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MKNK1(6), MKNK2(3), MOS(6), NFKB1(6), RAP1A(2), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), SHC1(2), SOS1(10), SOS2(13), TRAF3(5)	12049571	270	182	133	75	96	12	9	137	16	0	0.0110	1.000	1.000
129	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(6), ACADL(5), ACADM(4), ACOX1(8), ACOX2(6), ACOX3(13), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(27), ACSL6(12), ADIPOQ(5), ANGPTL4(5), APOA1(2), APOA5(5), APOC3(2), AQP7(3), CD36(6), CPT1A(14), CPT1B(8), CPT1C(17), CPT2(1), CYP27A1(3), CYP4A11(27), CYP4A22(23), CYP7A1(8), CYP8B1(13), DBI(1), EHHADH(6), FABP1(6), FABP2(8), FABP3(1), FABP4(1), FABP7(1), FADS2(4), GK(9), GK2(38), HMGCS2(21), ILK(2), LPL(6), ME1(20), MMP1(14), NR1H3(3), OLR1(5), PCK1(25), PCK2(6), PDPK1(3), PLTP(1), PPARA(7), PPARD(3), PPARG(14), RXRA(4), RXRB(4), RXRG(6), SCD(3), SCP2(4), SLC27A1(3), SLC27A2(16), SLC27A4(5), SLC27A5(9), SLC27A6(33), SORBS1(15), UBC(13), UCP1(5)	26866732	569	180	532	281	387	48	23	42	67	2	0.00538	1.000	1.000
130	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(34), ASH2L(4), CARM1(4), CTCFL(19), DOT1L(9), EED(3), EHMT1(10), EHMT2(11), EZH1(8), EZH2(11), FBXO11(7), HCFC1(19), JMJD4(4), JMJD6(1), KDM6A(2), MEN1(3), MLL(45), MLL2(91), MLL3(61), MLL5(12), NSD1(21), OGT(10), PAXIP1(3), PPP1CA(1), PPP1CB(5), PPP1CC(1), PRDM2(14), PRDM7(5), PRDM9(49), PRMT1(3), PRMT5(7), PRMT7(3), PRMT8(11), RBBP5(4), SATB1(20), SETD1A(23), SETD2(16), SETD7(1), SETD8(1), SETDB1(11), SETDB2(4), SETMAR(6), SMYD3(2), STK38(5), SUV39H1(1), SUV39H2(2), SUV420H1(6), SUV420H2(1), SUZ12(3), WHSC1(10), WHSC1L1(7)	48393327	614	179	593	236	395	64	22	71	62	0	0.0149	1.000	1.000
131	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(4), AKT2(8), AKT3(3), CDC42(2), CDKN1B(1), CDKN2A(42), CREB3(1), CREB5(9), ERBB4(54), F2RL2(8), GAB1(8), GRB2(2), GSK3A(1), GSK3B(3), IFI27(2), IGF1(10), IGFBP1(4), INPPL1(16), IRS1(5), IRS2(3), IRS4(13), MET(23), MYC(5), NOLC1(5), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARD3(18), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PPP1R13B(9), PREX1(9), PTEN(23), PTK2(7), PTPN1(4), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KB1(3), SHC1(2), SLC2A4(9), SOS1(10), SOS2(13), TSC1(9), TSC2(12), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	31642259	494	179	452	216	273	42	25	59	94	1	0.0362	1.000	1.000
132	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(22), ACAT2(1), ACMSD(13), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), AOC2(9), AOC3(10), AOX1(26), ASMT(9), CAT(8), CYP19A1(15), CYP1A1(9), CYP1A2(8), CYP2A13(12), CYP2A6(9), CYP2A7(10), CYP2B6(21), CYP2C19(75), CYP2C8(32), CYP2C9(38), CYP2D6(3), CYP2E1(13), CYP2F1(12), CYP2J2(7), CYP3A4(20), CYP3A7(30), CYP4B1(24), CYP4F8(18), CYP51A1(1), DDC(14), ECHS1(3), EHHADH(6), GCDH(6), HAAO(3), HADHA(6), KMO(8), KYNU(14), MAOA(4), MAOB(13), SDS(2), TDO2(4), TPH1(12), WARS(5), WARS2(4)	22470744	612	179	575	344	439	40	22	40	70	1	0.0312	1.000	1.000
133	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(10), AKR1D1(19), ARSD(3), ARSE(5), CARM1(4), CYP11B1(18), CYP11B2(14), CYP19A1(15), HEMK1(4), HSD11B1(14), HSD11B2(3), HSD17B12(3), HSD17B2(12), HSD17B3(5), HSD17B7(1), HSD3B1(14), HSD3B2(14), LCMT1(4), LCMT2(1), METTL2B(7), METTL6(1), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), SRD5A1(2), SRD5A2(6), STS(7), SULT1E1(16), SULT2A1(9), SULT2B1(7), UGT1A1(77), UGT2A1(35), UGT2A3(28), UGT2B10(45), UGT2B11(23), UGT2B15(31), UGT2B17(29), UGT2B28(26), UGT2B4(34), UGT2B7(19), WBSCR22(1)	20430011	594	178	543	229	413	53	18	34	75	1	1.71e-09	1.000	1.000
134	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(6), ATM(15), ATR(23), BAI1(16), BAX(3), CASP3(2), CASP8(9), CASP9(2), CCNB2(2), CCNB3(31), CCND1(2), CCND2(6), CCND3(2), CCNE1(4), CCNE2(8), CCNG1(2), CCNG2(1), CDK4(7), CDK6(2), CDKN1A(3), CDKN2A(42), CHEK1(2), CHEK2(2), CYCS(1), DDB2(3), EI24(3), FAS(6), GADD45B(2), GTSE1(9), IGF1(10), IGFBP3(2), MDM2(1), MDM4(2), PERP(2), PPM1D(4), PTEN(23), RFWD2(6), RPRM(3), RRM2(3), RRM2B(2), SERPINB5(8), SERPINE1(5), SESN1(2), SESN2(6), SESN3(1), STEAP3(8), THBS1(30), TNFRSF10B(4), TP53(51), TP53I3(2), TP73(6), TSC2(12), ZMAT3(1)	26553498	410	178	365	152	225	23	21	45	94	2	0.00103	1.000	1.000
135	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(15), ALG6(2), CCKBR(11), CCR2(17), CCR3(10), CCR5(10), CELSR1(30), CELSR2(32), CELSR3(35), CHRM2(25), CHRM3(26), CXCR3(4), DRD4(1), EDNRA(10), EMR2(5), EMR3(21), F2R(8), FSHR(19), GHRHR(5), GNRHR(2), GPR116(36), GPR132(3), GPR133(13), GPR143(4), GPR17(1), GPR18(4), GPR55(6), GPR56(4), GPR61(7), GPR77(6), GPR84(8), GRM1(16), GRPR(7), HRH4(6), LGR6(21), LPHN2(46), LPHN3(22), NTSR1(7), OR2M4(14), OR8G1(9), OR8G2(19), P2RY13(4), PTGFR(21), SMO(10), SSTR2(7), TAAR5(4), TSHR(8), VN1R1(1)	27235297	602	177	569	383	398	51	23	69	60	1	0.0544	1.000	1.000
136	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(3), AKT1(4), AKT2(8), AKT3(3), APAF1(6), ATM(15), BAX(3), BCL2(2), BIRC2(6), BIRC3(7), CAPN1(4), CAPN2(5), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CSF2RB(24), CYCS(1), DFFA(2), DFFB(2), FAS(6), FASLG(15), IKBKB(4), IL1A(5), IL1B(8), IL1R1(13), IL1RAP(3), IL3(3), IL3RA(7), IRAK1(5), IRAK2(15), IRAK3(10), IRAK4(3), MAP3K14(6), MYD88(3), NFKB1(6), NFKB2(3), NFKBIA(2), NTRK1(16), PIK3CA(10), PIK3CB(14), PIK3CD(8), PIK3CG(27), PIK3R1(2), PIK3R2(5), PIK3R3(2), PIK3R5(16), PPP3CA(5), PPP3CB(3), PPP3CC(2), PPP3R2(5), PRKACA(3), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), RIPK1(3), TNF(1), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(4), TNFRSF10D(9), TNFRSF1A(4), TNFSF10(8), TP53(51), TRAF2(2)	34029813	484	176	461	229	291	29	24	60	78	2	0.105	1.000	1.000
137	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(8), BCL2(2), CABIN1(16), CALM1(1), CALM2(1), CAMK2B(6), CAMK4(17), CD3E(2), CD3G(1), CD69(4), CDKN1A(3), CNR1(13), CREBBP(24), CSF2(2), CSNK2A1(4), CSNK2B(2), CTLA4(2), EGR2(5), EGR3(4), EP300(18), FCER1A(15), FCGR3A(7), FOS(2), GATA3(8), GATA4(4), GSK3A(1), GSK3B(3), HRAS(3), ICOS(2), IFNA1(1), IFNB1(6), IFNG(4), IL10(3), IL13(2), IL1B(8), IL2(4), IL2RA(5), IL3(3), IL4(1), IL6(2), IL8(1), ITK(24), KPNA5(3), MAP2K7(5), MAPK14(5), MAPK8(1), MAPK9(3), MEF2A(3), MEF2B(2), MEF2D(6), MYF5(15), NCK2(4), NFAT5(8), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NFKB2(3), NFKBIB(1), NPPB(6), NUP214(15), OPRD1(3), P2RX7(4), PAK1(4), PIN1(1), PPIA(1), PPP3CB(3), PPP3CC(2), PTPRC(35), RELA(4), RPL13A(2), SLA(4), SP1(5), SP3(1), TGFB1(2), TNF(1), TRAF2(2), TRPV6(30), VAV1(19), VAV2(3), VAV3(14), XPO5(7)	37285380	525	175	502	273	339	39	24	46	77	0	0.239	1.000	1.000
138	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(5), ADCY6(9), ADCY8(55), CACNA1A(38), CACNA1B(35), GNAS(25), GNAT3(5), GNB1(1), GNB3(7), GRM4(21), ITPR3(11), KCNB1(38), PDE1A(43), PLCB2(12), PRKACA(3), PRKACB(4), PRKACG(11), PRKX(3), SCNN1A(9), SCNN1B(14), SCNN1G(32), TAS1R1(13), TAS1R2(23), TAS1R3(2), TAS2R1(8), TAS2R10(8), TAS2R13(2), TAS2R14(3), TAS2R16(10), TAS2R3(2), TAS2R38(18), TAS2R39(13), TAS2R4(4), TAS2R40(4), TAS2R41(12), TAS2R42(2), TAS2R43(2), TAS2R46(3), TAS2R5(4), TAS2R50(2), TAS2R60(19), TAS2R7(5), TAS2R8(5), TAS2R9(9), TRPM5(14)	23151019	568	172	531	443	379	40	27	59	63	0	0.759	1.000	1.000
139	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(4), AKT2(8), AKT3(3), BCR(15), BTK(16), CD19(8), CDKN2A(42), DAPP1(6), FLOT1(2), GAB1(8), ITPR1(36), ITPR2(20), ITPR3(11), LYN(10), NR0B2(6), PDK1(2), PHF11(1), PIK3CA(10), PITX2(5), PLCG2(27), PPP1R13B(9), PREX1(9), PTEN(23), PTPRC(35), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KB1(3), SAG(11), SYK(14), TEC(13), VAV1(19)	22499282	391	171	347	180	226	25	22	36	82	0	0.00778	1.000	1.000
140	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(5), AGT(8), AGTR1(10), AGTR2(9), CMA1(5), COL4A1(64), COL4A2(35), COL4A3(44), COL4A4(114), COL4A5(68), COL4A6(42), REN(11)	10306129	415	170	386	106	317	19	8	25	45	1	0.0870	1.000	1.000
141	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(2), CDC40(7), CLK2(8), CLK3(2), COL2A1(42), CPSF1(8), CPSF2(2), CPSF3(3), CPSF4(1), CSTF1(6), CSTF2(4), CSTF2T(3), CSTF3(5), DDIT3(2), DDX1(2), DDX20(11), DHX15(6), DHX16(10), DHX38(9), DHX8(10), DHX9(11), DICER1(22), DNAJC8(2), FUS(1), GIPC1(4), LOC440563(26), LSM7(1), METTL3(2), NCBP1(1), NONO(10), NUDT21(3), NXF1(5), PAPOLA(4), PHF5A(3), POLR2A(13), PPM1G(2), PRPF18(4), PRPF3(5), PRPF4(3), PRPF4B(6), PRPF8(15), PSKH1(2), PTBP1(3), PTBP2(6), RBM17(1), RBM5(9), RNGTT(2), RNMT(9), RNPS1(2), SF3A1(7), SF3A2(6), SF3A3(6), SF3B1(16), SF3B2(11), SF3B4(7), SNRPA(2), SNRPA1(2), SNRPB(6), SNRPB2(2), SNRPD1(1), SNRPE(1), SNRPN(14), SPOP(2), SRPK1(9), SRPK2(2), SRRM1(8), SUPT5H(7), TXNL4A(1), U2AF2(5), XRN2(6)	43534202	441	169	431	169	259	37	28	54	63	0	0.0424	1.000	1.000
142	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(15), CCNA1(14), CCND1(2), CCND2(6), CCND3(2), CCNE1(4), CCNE2(8), CCNG2(1), CCNH(2), CDC25A(8), CDK4(7), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2A(42), CDKN2C(1), CREB3(1), CREB3L1(5), CREB3L3(10), CREB3L4(7), E2F1(5), E2F2(5), E2F3(5), E2F4(3), E2F5(3), E2F6(1), GBA2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(1), MNAT1(2), MYC(5), MYT1(21), PCNA(2), POLA2(8), POLE(16), POLE2(2), PRIM1(2), RB1(10), RBL1(12), RPA1(3), RPA2(1), TFDP1(2), TFDP2(4), TNXB(128), TP53(51), WEE1(2)	32246036	476	167	428	174	274	35	19	56	89	3	4.85e-05	1.000	1.000
143	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(3), ACTR3(2), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(2), ARHGAP1(3), ARHGAP4(4), ARHGEF11(20), BTK(16), CDC42(2), CFL1(2), GDI1(2), GDI2(2), INPPL1(16), ITPR1(36), ITPR2(20), ITPR3(11), LIMK1(5), MYLK(46), MYLK2(12), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3CG(27), PIK3R1(2), PITX2(5), PPP1R13B(9), PTEN(23), RACGAP1(4), RHO(2), ROCK1(7), ROCK2(11), SAG(11), WASF1(4), WASL(5)	28596765	439	166	413	196	279	33	21	53	52	1	0.00340	1.000	1.000
144	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(5), BAK1(1), BAX(3), BFAR(1), BTK(16), CAD(18), CASP10(6), CASP3(2), CASP8(9), CASP8AP2(10), CD7(1), CDK2AP1(2), CSNK1A1(3), DAXX(9), DEDD(1), DEDD2(3), DFFA(2), DIABLO(2), EGFR(25), EPHB2(34), FAF1(8), FAIM2(5), HSPB1(2), IL1A(5), IL8(1), MAP2K4(4), MAP2K7(5), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK10(9), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3), MET(23), NFAT5(8), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR0B2(6), PTPN13(15), RALBP1(3), RIPK1(3), ROCK1(7), SMPD1(2), TNFRSF6B(4), TP53(51), TPX2(11), TRAF2(2), TUFM(7)	29677726	408	166	387	192	236	30	22	47	72	1	0.131	1.000	1.000
145	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(4), AGT(8), AKT1(4), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK1G(11), CAMK4(17), CREBBP(24), CSNK1A1(3), EDN1(9), ELSPBP1(8), F2(11), FGF2(1), GATA4(4), GSK3B(3), HAND1(2), HAND2(5), HRAS(3), IGF1(10), LIF(1), MAP2K1(14), MAPK1(4), MAPK14(5), MAPK3(4), MAPK8(1), MEF2C(4), MYH2(97), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NKX2-5(1), NPPA(4), PIK3CA(10), PIK3R1(2), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RAF1(10), RPS6KB1(3), SYT1(23)	20820232	411	165	379	219	274	37	17	36	46	1	0.341	1.000	1.000
146	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(23), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(27), ACSL6(12), ADIPOQ(5), ADIPOR1(5), ADIPOR2(1), AGRP(1), AKT1(4), AKT2(8), AKT3(3), CAMKK1(3), CAMKK2(9), CD36(6), CHUK(2), CPT1A(14), CPT1B(8), CPT1C(17), CPT2(1), G6PC(5), G6PC2(4), IKBKB(4), IRS1(5), IRS2(3), IRS4(13), JAK1(6), JAK2(8), JAK3(11), LEP(4), LEPR(29), MAPK10(9), MAPK8(1), MAPK9(3), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(25), PCK2(6), POMC(4), PPARA(7), PPARGC1A(23), PRKAA1(1), PRKAA2(30), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8), PRKAG3(10), PRKCQ(20), PTPN11(10), RELA(4), RXRA(4), RXRB(4), RXRG(6), SLC2A1(5), SLC2A4(9), SOCS3(1), STAT3(9), STK11(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2), TYK2(8)	33982343	507	163	489	272	320	48	22	51	66	0	0.232	1.000	1.000
147	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(64), COL4A2(35), COL4A3(44), COL4A4(114), COL4A5(68), COL4A6(42), P4HB(4), SLC23A1(5), SLC23A2(2), SLC2A1(5), SLC2A3(7)	10188786	390	162	363	85	299	16	10	26	38	1	0.000807	1.000	1.000
148	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6), AGPAT1(1), AGPAT2(2), AGPAT3(6), AGPAT4(6), AKR1A1(3), AKR1B1(2), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), CEL(13), DGAT1(1), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKQ(7), DGKZ(6), GK(9), GLA(2), GLB1(9), LCT(51), LIPC(10), LIPF(18), LIPG(8), LPL(6), PNLIP(9), PNLIPRP1(10), PNLIPRP2(3), PPAP2A(1), PPAP2B(11), PPAP2C(8)	19725097	428	161	389	187	296	36	16	37	43	0	9.82e-05	1.000	1.000
149	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(4), ACYP1(1), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(3), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(9), ALDH9A1(2), ALDOA(2), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(3), FBP1(3), FBP2(2), G6PC(5), G6PC2(4), GALM(2), GAPDH(2), GAPDHS(3), GCK(17), GPI(3), HK1(3), HK2(13), HK3(14), LDHA(4), LDHAL6A(4), LDHAL6B(6), LDHB(2), LDHC(5), PDHA1(4), PDHA2(20), PDHB(1), PFKL(4), PFKM(2), PFKP(2), PGAM2(3), PGK1(2), PGK2(35), PGM1(6), PGM3(1), PKLR(13), PKM2(7), TPI1(1)	23828157	395	161	362	183	267	28	23	37	40	0	0.000366	1.000	1.000
150	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(4), BDKRB2(9), CALM1(1), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(7), FLT1(38), FLT4(30), KDR(55), NOS3(19), PDE2A(16), PDE3A(29), PDE3B(6), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKG1(14), PRKG2(16), RYR2(99), SLC7A1(6), SYT1(23), TNNI1(1)	16634479	412	160	390	221	276	33	11	42	49	1	0.104	1.000	1.000
151	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(4), ACP2(2), ACP5(3), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(10), ALPPL2(12), CYP19A1(15), CYP1A1(9), CYP1A2(8), CYP2A13(12), CYP2A6(9), CYP2A7(10), CYP2B6(21), CYP2C19(75), CYP2C8(32), CYP2C9(38), CYP2D6(3), CYP2E1(13), CYP2F1(12), CYP2J2(7), CYP3A4(20), CYP3A7(30), CYP4B1(24), CYP4F8(18), CYP51A1(1), PON1(21)	11932837	441	159	408	252	332	24	10	15	59	1	0.00233	1.000	1.000
152	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(14), ALOX12(6), ALOX12B(15), ALOX15(10), ALOX15B(8), ALOX5(12), CBR3(1), CYP2B6(21), CYP2C19(75), CYP2C8(32), CYP2C9(38), CYP2E1(13), CYP2J2(7), CYP2U1(2), CYP4A11(27), CYP4A22(23), CYP4F2(16), CYP4F3(24), DHRS4(2), EPHX2(5), GGT1(8), GPX1(3), GPX3(4), GPX5(17), GPX6(16), LTA4H(5), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PTGDS(3), PTGES(1), PTGES2(1), PTGIS(17), PTGS1(20), PTGS2(13), TBXAS1(16)	15836940	544	158	510	315	395	36	10	33	67	3	0.00945	1.000	1.000
153	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(4), AKT2(8), AKT3(3), BCL2(2), BCR(15), BLNK(15), BTK(16), CD19(8), CD22(23), CD81(2), CR2(34), CSK(1), DAG1(9), FLOT1(2), GRB2(2), GSK3A(1), GSK3B(3), INPP5D(37), ITPR1(36), ITPR2(20), ITPR3(11), LYN(10), MAP4K1(11), MAPK1(4), MAPK3(4), NFATC1(16), NFATC2(11), NR0B2(6), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(2), PLCG2(27), PPP1R13B(9), PPP3CA(5), PPP3CB(3), PPP3CC(2), PTPRC(35), RAF1(10), SHC1(2), SOS1(10), SOS2(13), SYK(14), VAV1(19)	30224112	485	157	463	225	311	34	29	44	65	2	0.00489	1.000	1.000
154	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(7), BMP4(4), BMP5(32), BMP6(12), BMP7(5), BMP8A(2), BTRC(4), CSNK1A1(3), CSNK1A1L(7), CSNK1D(3), CSNK1E(5), CSNK1G1(5), CSNK1G2(3), CSNK1G3(3), DHH(2), FBXW11(6), GLI1(17), GLI2(42), GLI3(18), GSK3B(3), HHIP(25), IHH(3), LRP2(100), PRKACA(3), PRKACB(4), PRKACG(11), PRKX(3), PTCH1(7), PTCH2(17), RAB23(1), SHH(3), SMO(10), STK36(16), SUFU(2), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(3), WNT2(8), WNT2B(5), WNT3(5), WNT3A(9), WNT4(1), WNT5A(5), WNT5B(4), WNT6(3), WNT7A(14), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(6), ZIC2(3)	24707650	496	156	466	229	339	44	18	44	51	0	0.00196	1.000	1.000
155	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(6), ACAA2(1), ACADL(5), ACADM(4), ACADS(5), ACADSB(5), ACADVL(1), ACAT2(1), ACOX1(8), ACOX3(13), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(27), ACSL6(12), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), CPT1A(14), CPT1B(8), CPT1C(17), CPT2(1), CYP4A11(27), CYP4A22(23), ECHS1(3), EHHADH(6), GCDH(6), HADH(2), HADHA(6), HADHB(5), HSD17B10(2), HSD17B4(6)	20126707	374	155	345	158	265	25	21	24	38	1	0.000389	1.000	1.000
156	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(13), ACTB(8), ACTG1(6), ARHGEF2(19), ARPC5(1), CD14(5), CDC42(2), CDH1(5), CLDN1(5), CTNNB1(14), CTTN(4), EZR(5), FYN(7), HCLS1(13), ITGB1(4), KRT18(4), LY96(4), NCK1(2), NCK2(4), NCL(6), OCLN(7), PRKCA(8), RHOA(2), ROCK1(7), ROCK2(11), TLR4(41), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(1), TUBA3C(23), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(12), WAS(8), WASL(5), YWHAQ(3)	21477402	350	155	331	147	225	34	13	40	38	0	0.000558	1.000	1.000
157	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(13), ACTB(8), ACTG1(6), ARHGEF2(19), ARPC5(1), CD14(5), CDC42(2), CDH1(5), CLDN1(5), CTNNB1(14), CTTN(4), EZR(5), FYN(7), HCLS1(13), ITGB1(4), KRT18(4), LY96(4), NCK1(2), NCK2(4), NCL(6), OCLN(7), PRKCA(8), RHOA(2), ROCK1(7), ROCK2(11), TLR4(41), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(1), TUBA3C(23), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(12), WAS(8), WASL(5), YWHAQ(3)	21477402	350	155	331	147	225	34	13	40	38	0	0.000558	1.000	1.000
158	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(4), AKT2(8), AKT3(3), BRD4(21), CAP1(2), CBL(10), CDC42(2), CDKN2A(42), F2RL2(8), FLOT1(2), GRB2(2), GSK3A(1), GSK3B(3), IGFBP1(4), INPPL1(16), IRS1(5), IRS2(3), IRS4(13), LNPEP(11), MAPK1(4), MAPK3(4), PARD3(18), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(2), PPYR1(14), PTEN(23), PTPN1(4), RAF1(10), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KB1(3), SERPINB6(4), SHC1(2), SLC2A4(9), SORBS1(15), SOS1(10), SOS2(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	24433210	339	155	310	140	162	33	19	51	73	1	0.0896	1.000	1.000
159	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(6), ACTG2(6), ACTR2(3), ACTR3(2), AKT1(4), ANGPTL2(2), CDC42(2), CFL1(2), FLNA(21), FLNC(65), FSCN1(4), FSCN2(2), FSCN3(12), GDI1(2), GDI2(2), LIMK1(5), MYH2(97), MYLK(46), MYLK2(12), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), RHO(2), ROCK1(7), ROCK2(11), VASP(3), WASF1(4), WASL(5)	19539036	417	155	381	220	290	45	12	33	37	0	0.0124	1.000	1.000
160	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(5), AKT1(4), APC(25), CAMP(2), CAV3(2), DAG1(9), DLG4(6), EPHB2(34), GNAI1(2), GNAQ(6), ITPR1(36), ITPR2(20), ITPR3(11), KCNJ3(20), KCNJ5(13), KCNJ9(6), MAPK1(4), PITX2(5), PTX3(1), RAC1(20), RHO(2), RYR1(109)	18637526	342	155	319	198	232	30	17	27	36	0	0.115	1.000	1.000
161	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(22), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(8), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(10), AOX1(26), CARM1(4), COMT(3), DBH(15), DCT(4), DDC(14), ESCO1(2), ESCO2(4), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HEMK1(4), HGD(13), HPD(7), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(7), METTL6(1), PNMT(4), PNPLA3(3), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), SH3GLB1(2), TAT(19), TH(12), TPO(47), TYR(9), TYRP1(10), WBSCR22(1)	24309275	437	154	410	218	308	32	24	33	40	0	0.0385	1.000	1.000
162	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(5), ALAS1(2), ALAS2(5), BLVRA(2), BLVRB(1), COX10(6), COX15(3), CP(12), CPOX(4), EARS2(2), EPRS(13), FECH(3), FTH1(3), FTMT(6), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(2), PPOX(4), UGT1A1(77), UGT2A1(35), UGT2A3(28), UGT2B10(45), UGT2B11(23), UGT2B15(31), UGT2B17(29), UGT2B28(26), UGT2B4(34), UGT2B7(19), UROS(1)	17255102	431	154	393	148	303	32	13	23	59	1	7.64e-08	1.000	1.000
163	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), APH1A(3), CREBBP(24), CTBP2(1), DLL1(2), DLL3(7), DLL4(8), DTX1(7), DTX2(3), DTX3(4), DTX3L(6), DTX4(4), DVL2(3), DVL3(8), EP300(18), HDAC1(2), HDAC2(2), HES1(2), JAG1(9), JAG2(7), LFNG(3), MAML1(9), MAML2(7), MAML3(9), MFNG(9), NCOR2(26), NCSTN(5), NOTCH1(9), NOTCH2(33), NOTCH3(26), NOTCH4(62), NUMB(4), NUMBL(4), PSEN1(1), PSEN2(2), PTCRA(3), RBPJ(6), RBPJL(4), SNW1(2)	28131096	345	153	342	178	206	32	11	59	36	1	0.578	1.000	1.000
164	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(9), CAD(18), CANT1(10), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(67), DPYS(24), ENTPD1(12), ENTPD3(9), ENTPD4(4), ENTPD5(2), ENTPD6(4), ENTPD8(2), ITPA(1), NME4(1), NME6(3), NME7(4), NT5C1A(6), NT5C2(3), NT5C3(2), NT5E(6), NT5M(2), NUDT2(1), PNPT1(3), POLA1(3), POLA2(8), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3A(7), POLR3B(14), POLR3G(1), POLR3GL(2), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(21), RRM1(3), RRM2(3), RRM2B(2), TK2(1), TXNRD1(5), TXNRD2(3), TYMS(1), UCK1(3), UCK2(1), UMPS(2), UPB1(10), UPP1(1), UPP2(6), UPRT(1)	33137454	402	151	376	194	260	35	14	52	41	0	0.0619	1.000	1.000
165	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(4), ATF2(6), CDC42(2), DLD(3), DUSP10(7), DUSP4(2), DUSP8(3), GAB1(8), GCK(17), IL1R1(13), JUN(1), MAP2K4(4), MAP2K5(4), MAP2K7(5), MAP3K1(4), MAP3K10(9), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(6), MAP3K3(8), MAP3K4(17), MAP3K5(23), MAP3K7(1), MAP3K9(26), MAPK10(9), MAPK7(4), MAPK8(1), MAPK9(3), MYEF2(4), NFATC3(10), NR2C2(1), PAPPA(59), SHC1(2), TP53(51), TRAF6(4)	20588903	345	150	324	142	221	26	12	34	50	2	0.0701	1.000	1.000
166	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), ELK1(3), FPR1(21), GNA15(6), GNB1(1), HRAS(3), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(4), NCF1(3), NCF2(9), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NFKB1(6), NFKBIA(2), PAK1(4), PIK3C2G(53), PLCB1(54), PPP3CA(5), PPP3CB(3), PPP3CC(2), RAC1(20), RAF1(10), RELA(4), SYT1(23)	15580129	351	149	307	136	240	25	14	34	38	0	0.000987	1.000	1.000
167	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(56), B3GALT4(2), CDR1(14), DGKI(31), IL6ST(10), MRPL19(1), PIGK(7), RPL10(3), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL15(2), RPL18(5), RPL18A(2), RPL19(1), RPL21(1), RPL22(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL38(1), RPL39(1), RPL3L(5), RPL4(4), RPL5(7), RPL6(1), RPL7(1), RPLP0(1), RPS11(1), RPS13(1), RPS15(1), RPS16(2), RPS18(2), RPS19(1), RPS2(2), RPS20(2), RPS24(1), RPS26(1), RPS27(25), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KA6(19), RPS6KB1(3), RPS6KB2(2), RPS7(4), RPS8(1), RPSA(10), SLC36A2(11), TBC1D10C(5), TSPAN9(4), UBC(13)	21249307	309	149	273	155	183	24	16	28	58	0	0.102	1.000	1.000
168	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(5), UGDH(1), UGP2(1), UGT1A1(77), UGT2A1(35), UGT2A3(28), UGT2B10(45), UGT2B11(23), UGT2B15(31), UGT2B17(29), UGT2B28(26), UGT2B4(34), UGT2B7(19), XYLB(6)	11148897	362	147	324	126	261	25	9	17	49	1	1.06e-06	1.000	1.000
169	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(8), ADAM17(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A2(5), ATP6V0A4(22), ATP6V0D1(1), ATP6V0D2(10), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), CASP3(2), CDC42(2), CHUK(2), CSK(1), EGFR(25), F11R(7), GIT1(4), HBEGF(1), IGSF5(11), IKBKB(4), IL8(1), JAM2(11), JAM3(3), JUN(1), LYN(10), MAP2K4(4), MAP3K14(6), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK8(1), MAPK9(3), MET(23), NFKB1(6), NFKB2(3), NFKBIA(2), NOD1(9), PAK1(4), PLCG1(8), PLCG2(27), PTPN11(10), PTPRZ1(26), RAC1(20), RELA(4), SRC(2), TCIRG1(5), TJP1(13)	28815528	380	147	361	212	240	30	17	46	47	0	0.543	1.000	1.000
170	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(10), CD28(2), CD3D(7), CSK(1), CTLA4(2), DAG1(9), EPHB2(34), FBXW7(11), GRAP2(5), GRB2(2), ITK(24), ITPKB(11), LAT(2), LCK(15), LCP2(9), MAPK1(4), NCK1(2), NFAT5(8), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PAK1(4), PAK2(7), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLCG1(8), PTPRC(35), RAF1(10), RASGRP1(11), RASGRP2(7), RASGRP3(12), RASGRP4(11), SOS1(10), SOS2(13), VAV1(19), ZAP70(7)	22687512	406	147	386	190	257	31	18	45	55	0	0.0601	1.000	1.000
171	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(7), F11(12), F12(1), F13B(32), F2(11), F5(36), F7(7), F8(49), F9(15), FGA(41), FGB(10), FGG(10), LPA(55), PLAT(4), PLAU(3), PLG(34), SERPINB2(36), SERPINE1(5), SERPINF2(7), VWF(56)	14386165	431	146	407	170	304	29	22	34	42	0	0.00331	1.000	1.000
172	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(3), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(2), ALDOA(2), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(3), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GCK(17), GPI(3), HK1(3), HK2(13), HK3(14), LDHA(4), LDHB(2), LDHC(5), PDHA1(4), PDHA2(20), PDHB(1), PFKM(2), PFKP(2), PGK1(2), PGM1(6), PGM3(1), PKLR(13), PKM2(7), TPI1(1)	20003254	335	146	307	143	225	27	19	30	34	0	4.87e-05	1.000	1.000
173	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(3), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(2), ALDOA(2), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(3), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GCK(17), GPI(3), HK1(3), HK2(13), HK3(14), LDHA(4), LDHB(2), LDHC(5), PDHA1(4), PDHA2(20), PDHB(1), PFKM(2), PFKP(2), PGK1(2), PGM1(6), PGM3(1), PKLR(13), PKM2(7), TPI1(1)	20003254	335	146	307	143	225	27	19	30	34	0	4.87e-05	1.000	1.000
174	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(25), AXIN1(9), CCND1(2), CCND2(6), CCND3(2), CSNK1E(5), CTNNB1(14), DVL2(3), DVL3(8), FBXW2(2), FZD1(5), FZD10(4), FZD2(6), FZD3(1), FZD5(2), FZD6(2), FZD7(4), FZD8(5), FZD9(1), GSK3B(3), JUN(1), LDLR(17), MAPK10(9), MAPK9(3), MYC(5), PAFAH1B1(4), PLAU(3), PPP2R5C(4), PPP2R5E(5), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(20), PRKCZ(7), PRKD1(9), RAC1(20), RHOA(2), SFRP4(5), TCF7(1), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(3), WNT2(8), WNT2B(5), WNT3(5), WNT4(1), WNT5A(5), WNT5B(4), WNT6(3), WNT7A(14), WNT7B(6)	24442250	349	146	331	185	215	33	10	38	53	0	0.181	1.000	1.000
175	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(3), INPP4A(7), INPP4B(2), INPP5A(4), INPPL1(16), ITPKB(11), MIOX(4), OCRL(6), PIK3C2A(8), PIK3C2B(16), PIK3C2G(53), PIK3CA(10), PIK3CB(14), PIK3CG(27), PLCB1(54), PLCB2(12), PLCB3(4), PLCB4(86), PLCD1(4), PLCG1(8), PLCG2(27)	18236832	377	145	339	168	264	16	16	32	47	2	0.00332	1.000	1.000
176	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(4), AKT2(8), AKT3(3), BCR(15), BLNK(15), BTK(16), CD19(8), CSK(1), DAG1(9), EPHB2(34), GRB2(2), ITPKB(11), LYN(10), MAP2K1(14), MAP2K2(5), MAPK1(4), NFAT5(8), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PI3(6), PIK3CA(10), PIK3CD(8), PIK3R1(2), PLCG2(27), PPP1R13B(9), RAF1(10), SERPINA4(20), SHC1(2), SOS1(10), SOS2(13), SYK(14), VAV1(19)	21622033	332	145	315	166	208	26	14	39	44	1	0.164	1.000	1.000
177	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(8), AGPAT1(1), AGPAT2(2), AGPAT3(6), AGPAT4(6), AGPAT6(3), CDS1(11), CDS2(5), CHAT(17), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKI(31), DGKQ(7), DGKZ(6), ESCO1(2), ESCO2(4), ETNK1(5), GNPAT(1), GPAM(7), GPD1(9), GPD1L(2), GPD2(3), LYPLA1(1), LYPLA2(1), PCYT1A(3), PCYT1B(9), PEMT(2), PISD(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLD1(13), PLD2(8), PNPLA3(3), PPAP2A(1), PPAP2B(11), PPAP2C(8), PTDSS2(3), SH3GLB1(2)	26714115	359	144	339	178	228	30	15	34	51	1	0.0997	1.000	1.000
178	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(5), AANAT(1), ABP1(22), ACAT2(1), ACMSD(13), AFMID(2), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), AOC2(9), AOC3(10), AOX1(26), ASMT(9), CARM1(4), CAT(8), CYP1A1(9), CYP1A2(8), CYP1B1(4), DDC(14), ECHS1(3), EHHADH(6), GCDH(6), HAAO(3), HADH(2), HADHA(6), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(12), KMO(8), KYNU(14), LCMT1(4), LCMT2(1), LNX1(18), MAOA(4), MAOB(13), METTL2B(7), METTL6(1), NFX1(8), OGDH(8), OGDHL(42), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), TDO2(4), TPH1(12), TPH2(13), WARS(5), WARS2(4), WBSCR22(1)	24761101	432	143	414	219	294	33	23	44	37	1	0.0520	1.000	1.000
179	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(1), DLG4(6), GRIN1(8), GRIN2A(105), GRIN2B(57), GRIN2C(8), GRIN2D(10), NOS1(74), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), SYT1(23)	10424841	339	143	315	204	247	31	6	21	33	1	0.164	1.000	1.000
180	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(22), AGMAT(4), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH4A1(6), ALDH9A1(2), AOC2(9), AOC3(10), ARG1(2), ARG2(2), ASL(6), CKM(3), CKMT1A(1), CKMT2(5), CPS1(26), DAO(11), GAMT(4), GATM(6), GLUD1(2), GOT1(6), GOT2(6), MAOA(4), MAOB(13), NOS1(74), NOS3(19), OAT(4), ODC1(3), OTC(4), P4HA1(10), P4HA2(6), P4HA3(12), P4HB(4), PYCR1(1), RARS(7), SMS(4)	18027383	348	142	331	186	222	35	19	30	42	0	0.104	1.000	1.000
181	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(4), CALR(2), CANX(1), CD4(8), CD74(7), CD8A(2), CD8B(7), CIITA(18), CTSL1(1), CTSS(7), HLA-A(3), HLA-C(9), HLA-DMA(7), HLA-DMB(7), HLA-DOA(5), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(12), HLA-DRB5(6), HLA-E(1), HLA-F(4), HLA-G(6), HSP90AA1(3), HSP90AB1(6), HSPA5(6), IFI30(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), KIR2DL1(29), KIR3DL2(45), KIR3DL3(6), KLRC1(4), KLRC2(14), KLRC4(6), KLRD1(5), LGMN(6), LTA(4), NFYA(1), NFYB(2), NFYC(2), PDIA3(3), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(2), TAP2(14), TAPBP(2)	18863355	362	142	347	213	241	34	12	35	40	0	0.373	1.000	1.000
182	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(6), BAK1(1), BAX(3), BCL2(2), BCL2L11(5), BIRC2(6), BIRC3(7), BIRC5(1), BNIP3L(2), CASP1(10), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CHUK(2), CYCS(1), DFFA(2), DFFB(2), FAS(6), FASLG(15), GZMB(3), HELLS(5), IKBKB(4), IRF1(1), IRF2(6), IRF3(3), IRF4(2), IRF5(5), IRF6(15), IRF7(5), JUN(1), LTA(4), MAP2K4(4), MAP3K1(4), MAPK10(9), MDM2(1), MYC(5), NFKB1(6), NFKBIA(2), NFKBIB(1), PLEKHG5(11), PRF1(11), RELA(4), RIPK1(3), TNF(1), TNFRSF10B(4), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(11), TNFRSF25(6), TNFSF10(8), TP53(51), TP73(6), TRAF1(6), TRAF2(2), TRAF3(5)	23419286	320	141	305	143	197	26	17	27	52	1	0.0381	1.000	1.000
183	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(4), CRK(3), CRKL(3), DOCK1(17), ELK1(3), FOS(2), GAB1(8), GRB2(2), HGF(29), HRAS(3), ITGA1(24), ITGB1(4), JUN(1), MAP2K1(14), MAP2K2(5), MAP4K1(11), MAPK1(4), MAPK3(4), MAPK8(1), MET(23), PAK1(4), PIK3CA(10), PIK3R1(2), PTEN(23), PTK2(7), PTK2B(10), PTPN11(10), PXN(2), RAF1(10), RAP1A(2), RAP1B(1), RASA1(4), SOS1(10), SRC(2), STAT3(9)	17864674	271	141	253	118	149	20	12	47	42	1	0.391	1.000	1.000
184	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(15), BMPR1B(4), CCND2(6), CDK4(7), CDKN1B(1), DAZL(5), DMC1(12), EGR1(4), ESR2(9), FSHR(19), GJA4(4), INHA(4), LHCGR(27), MLH1(6), MSH5(17), NCOR1(23), NR5A1(9), NRIP1(8), PGR(16), PRLR(35), PTGER2(7), SMPD1(2), VDR(3), ZP2(16)	14286501	259	141	234	129	168	18	8	30	35	0	0.473	1.000	1.000
185	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(8), AGPAT1(1), AGPAT2(2), AGPAT3(6), AGPAT4(6), AGPS(4), CDS1(11), CDS2(5), CHAT(17), CHKA(2), CHKB(3), CLC(5), CPT1B(8), DGKA(3), DGKB(27), DGKD(14), DGKE(8), DGKG(18), DGKH(10), DGKQ(7), DGKZ(6), ETNK1(5), GNPAT(1), GPD1(9), GPD2(3), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(3), PCYT1B(9), PEMT(2), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLCB2(12), PLCG1(8), PLCG2(27), PPAP2A(1), PPAP2B(11), PPAP2C(8)	20419082	338	140	323	165	228	24	11	27	47	1	0.00727	1.000	1.000
186	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(22), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(8), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(10), AOX1(26), COMT(3), DBH(15), DCT(4), DDC(14), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HGD(13), HPD(7), MAOA(4), MAOB(13), PNMT(4), TAT(19), TH(12), TPO(47), TYR(9)	12935371	363	140	337	185	267	23	17	22	34	0	0.00741	1.000	1.000
187	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(9), B4GALT1(2), B4GALT2(2), G6PC(5), G6PC2(4), GAA(8), GALK1(2), GALK2(2), GALT(2), GANC(7), GCK(17), GLA(2), GLB1(9), HK1(3), HK2(13), HK3(14), HSD3B7(5), LALBA(7), LCT(51), MGAM(162), PFKL(4), PFKM(2), PFKP(2), PGM1(6), PGM3(1), RDH11(1), RDH12(2), RDH13(3), UGP2(1)	15769833	350	139	327	187	258	28	7	30	27	0	0.0212	1.000	1.000
188	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(48), C5(21), C6(72), C7(47), ICAM1(2), IL1A(5), IL6(2), IL8(1), ITGA4(43), ITGAL(28), ITGB1(4), ITGB2(16), SELP(39), SELPLG(10), TNF(1), VCAM1(17)	10087316	356	138	323	143	256	9	14	34	41	2	0.000211	1.000	1.000
189	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(2), AKT1(4), AKT2(8), AKT3(3), BTK(16), CDKN2A(42), DAPP1(6), GRB2(2), GSK3A(1), GSK3B(3), IARS(8), IGFBP1(4), INPP5D(37), PDK1(2), PIK3CA(10), PPP1R13B(9), PTEN(23), RPS6KA1(8), RPS6KA2(6), RPS6KA3(1), RPS6KB1(3), SHC1(2), SOS1(10), SOS2(13), TEC(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	14737777	244	138	207	70	126	14	14	28	62	0	0.000459	1.000	1.000
190	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), B4GALT2(2), FBP2(2), G6PC(5), GAA(8), GALK1(2), GALK2(2), GALT(2), GANAB(5), GCK(17), GLA(2), GLB1(9), HK1(3), HK2(13), HK3(14), LALBA(7), LCT(51), MGAM(162), PFKM(2), PFKP(2), PGM1(6), PGM3(1)	13294172	321	136	298	169	236	28	7	26	24	0	0.0209	1.000	1.000
191	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(9), ABP1(22), ACADL(5), ACADM(4), ACADSB(5), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), AOC2(9), AOC3(10), CNDP1(8), DPYD(67), DPYS(24), ECHS1(3), EHHADH(6), GAD1(13), GAD2(9), HADHA(6), MLYCD(2), SDS(2), SMS(4), UPB1(10)	11911882	270	135	249	125	178	21	13	31	27	0	0.0327	1.000	1.000
192	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(2), C1GALT1(6), C1GALT1C1(3), GALNT1(4), GALNT10(7), GALNT11(2), GALNT12(8), GALNT13(29), GALNT14(24), GALNT2(6), GALNT3(4), GALNT4(5), GALNT5(13), GALNT6(17), GALNT7(4), GALNT8(27), GALNT9(7), GALNTL1(6), GALNTL2(22), GALNTL4(10), GALNTL5(18), GCNT1(6), GCNT3(7), GCNT4(4), OGT(10), ST3GAL1(7), ST3GAL2(1), ST6GALNAC1(8), WBSCR17(44)	13230375	312	135	292	147	219	14	7	32	40	0	0.0819	1.000	1.000
193	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(9), ALOX15(10), ALOX5(12), CYP1A2(8), CYP2C19(75), CYP2C8(32), CYP2C9(38), CYP2E1(13), CYP2J2(7), CYP3A4(20), CYP3A43(19), CYP3A7(30), HSD3B7(5), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), RDH11(1), RDH12(2), RDH13(3)	9779141	353	135	329	189	261	17	10	14	49	2	0.00887	1.000	1.000
194	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(8), APOA1(2), CD36(6), CPT1B(8), CREBBP(24), DUSP1(1), EHHADH(6), EP300(18), FABP1(6), HSD17B4(6), JUN(1), LPL(6), MAPK1(4), MAPK3(4), ME1(20), MRPL11(1), MYC(5), NCOA1(9), NCOR1(23), NCOR2(26), NFKBIA(2), NR0B2(6), NR1H3(3), NR2F1(8), NRIP1(8), PDGFA(1), PIK3CA(10), PIK3R1(2), PPARA(7), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), PTGS2(13), RB1(10), RELA(4), RXRA(4), SP1(5), STAT5A(3), STAT5B(6), TNF(1)	25964199	313	134	304	142	194	30	22	32	31	4	0.126	1.000	1.000
195	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(16), CALM1(1), CALM2(1), ELK1(3), FCER1A(15), FCER1G(1), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(10), MAP2K1(14), MAP2K4(4), MAP2K7(5), MAP3K1(4), MAPK1(4), MAPK3(4), MAPK8(1), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), PAK2(7), PIK3CA(10), PIK3R1(2), PLA2G4A(15), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), RAF1(10), SHC1(2), SOS1(10), SYK(14), SYT1(23), VAV1(19)	17590831	275	133	260	125	170	17	14	35	38	1	0.300	1.000	1.000
196	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(18), CANT1(10), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(67), DPYS(24), ENTPD1(12), ITPA(1), NT5E(6), NT5M(2), NUDT2(1), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(9), POLL(8), POLQ(25), POLR1B(9), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLRMT(3), RRM1(3), RRM2(3), TK2(1), TXNRD1(5), TYMS(1), UCK1(3), UCK2(1), UMPS(2), UNG(5), UPB1(10), UPP1(1)	23488831	306	133	285	132	195	27	10	42	32	0	0.00575	1.000	1.000
197	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), ALDOB(14), ALDOC(4), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(3), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GAPDHS(3), GCK(17), GOT1(6), GOT2(6), GPI(3), HK1(3), HK2(13), HK3(14), LDHA(4), LDHAL6B(6), LDHB(2), LDHC(5), MDH1(3), MDH2(3), PC(14), PCK1(25), PDHA1(4), PDHA2(20), PDHB(1), PDHX(2), PFKL(4), PFKM(2), PFKP(2), PGAM2(3), PGK1(2), PGK2(35), PKLR(13), PKM2(7), TNFAIP1(1), TPI1(1)	17414717	275	132	261	142	194	21	14	20	26	0	0.00853	1.000	1.000
198	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(6), C1QB(7), C1R(16), C1S(20), C3(48), C5(21), C6(72), C7(47), C8A(43), C8B(46), C9(22), MASP1(10)	8434027	358	131	317	138	269	15	9	29	34	2	7.93e-05	1.000	1.000
199	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(9), ABP1(22), ACADM(4), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), AOC2(9), AOC3(10), CNDP1(8), DPYD(67), DPYS(24), ECHS1(3), EHHADH(6), GAD1(13), GAD2(9), HADHA(6), HIBCH(1), MLYCD(2), SMS(4), SRM(1), UPB1(10)	11079449	250	131	230	121	163	20	14	29	24	0	0.0762	1.000	1.000
200	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CALM2(1), CD3D(7), CD3E(2), CD3G(1), ELK1(3), FOS(2), FYN(7), GRB2(2), HRAS(3), JUN(1), LAT(2), LCK(15), MAP2K1(14), MAP2K4(4), MAP3K1(4), MAPK3(4), MAPK8(1), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), NFKB1(6), NFKBIA(2), PIK3CA(10), PIK3R1(2), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKCA(8), PTPN7(3), RAC1(20), RAF1(10), RASA1(4), RELA(4), SHC1(2), SOS1(10), SYT1(23), VAV1(19), ZAP70(7)	19544935	276	131	251	117	172	25	11	35	32	1	0.114	1.000	1.000
201	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(15), BTK(16), CALM1(1), CALM2(1), CD79A(3), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(10), MAP2K1(14), MAP3K1(4), MAPK14(5), MAPK3(4), MAPK8(1), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKCA(8), RAC1(20), RAF1(10), SHC1(2), SOS1(10), SYK(14), SYT1(23), VAV1(19)	15653585	263	130	238	114	172	15	10	33	33	0	0.118	1.000	1.000
202	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(8), AGTR2(9), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CDK5(6), F2(11), FYN(7), GNA11(8), GNAI1(2), GNB1(1), GRB2(2), HRAS(3), JAK2(8), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK14(5), MAPK3(4), MAPK8(1), MAPT(11), MYLK(46), PLCG1(8), PRKCA(8), PTK2B(10), RAF1(10), SHC1(2), SOS1(10), STAT1(5), STAT3(9), STAT5A(3), SYT1(23)	16971149	268	130	248	149	167	22	13	35	31	0	0.490	1.000	1.000
203	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(65), GABBR1(8), GPRC5A(4), GPRC5B(5), GPRC5C(10), GPRC5D(2), GRM1(16), GRM2(13), GRM3(62), GRM4(21), GRM5(15), GRM7(40), GRM8(48)	8565104	309	130	288	218	225	21	12	23	28	0	0.190	1.000	1.000
204	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(8), AADAC(15), ABAT(9), ACADS(5), ACAT2(1), ACSM1(28), AKR1B10(9), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH5A1(10), ALDH7A1(9), ALDH9A1(2), BDH1(5), DDHD1(7), ECHS1(3), EHHADH(6), GAD1(13), GAD2(9), HADH(2), HADHA(6), HMGCL(4), HMGCS1(3), HMGCS2(21), HSD17B10(2), HSD17B4(6), HSD3B7(5), ILVBL(5), L2HGDH(3), OXCT1(4), OXCT2(5), PDHA1(4), PDHA2(20), PDHB(1), PLA1A(10), PPME1(1), PRDX6(4), RDH11(1), RDH12(2), RDH13(3)	16638592	282	130	271	134	185	26	18	21	32	0	0.0350	1.000	1.000
205	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(3), ACTR3(2), AKT1(4), ANGPTL2(2), DAG1(9), DGKA(3), ETFA(3), GCA(3), ITGA9(13), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), MAP2K1(14), MAPK1(4), MAPK3(4), NR1I3(6), PAK1(4), PDE3A(29), PDE3B(6), PI3(6), PIK3C2G(53), PIK3CA(10), PIK3CD(8), PIK3R1(2), RIPK3(11), VASP(3)	19830206	280	130	255	117	190	21	13	26	29	1	0.000909	1.000	1.000
206	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(4), AKT2(8), AKT3(3), ANKRD6(3), APC(25), AXIN1(9), AXIN2(4), CER1(16), CSNK1A1(3), CTNNB1(14), DACT1(13), DKK1(2), DKK2(19), DKK3(4), DKK4(3), FSTL1(3), GSK3A(1), GSK3B(3), LRP1(40), MVP(11), NKD1(8), NKD2(7), PIN1(1), PSEN1(1), PTPRA(9), SENP2(14), SFRP1(3), TSHB(6), WIF1(7)	16380018	244	130	235	117	138	30	10	30	36	0	0.204	1.000	1.000
207	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(10), AKR1D1(19), ARSB(2), ARSD(3), ARSE(5), CYP11B1(18), CYP11B2(14), HSD11B1(14), HSD11B2(3), HSD17B2(12), HSD17B3(5), HSD3B1(14), HSD3B2(14), SRD5A1(2), SRD5A2(6), STS(7), SULT1E1(16), SULT2A1(9), UGT1A1(77), UGT2B15(31), UGT2B4(34)	11154654	315	129	289	132	215	31	11	19	38	1	6.62e-05	1.000	1.000
208	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(13), ATM(15), ATR(23), CCNA1(14), CCND1(2), CCNE1(4), CDC25A(8), CDK4(7), CDK6(2), CDKN1A(3), CDKN1B(1), CDKN2A(42), DHFR(2), E2F1(5), GSK3B(3), HDAC1(2), RB1(10), SKP2(2), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3), TP53(51)	12356554	219	129	182	52	105	10	13	21	67	3	5.55e-06	1.000	1.000
209	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(6), BCR(15), BLNK(15), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(10), MAP2K1(14), MAP3K1(4), MAPK1(4), MAPK3(4), MAPK8IP3(10), PAPPA(59), RAC1(20), RPS6KA1(8), RPS6KA3(1), SHC1(2), SOS1(10), SYK(14), VAV1(19), VAV2(3), VAV3(14)	13035383	243	129	216	136	164	18	4	25	31	1	0.623	1.000	1.000
210	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(6), C1QB(7), C1R(16), C1S(20), C3(48), C5(21), C6(72), C7(47), C8A(43), C9(22), MASP1(10), MASP2(11), MBL2(13)	8639698	336	128	300	128	256	13	6	26	33	2	7.68e-05	1.000	1.000
211	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(20), ACACB(23), ACAT2(1), ACOT12(14), ACSS1(2), ACSS2(4), ACYP1(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(2), LDHA(4), LDHAL6A(4), LDHAL6B(6), LDHB(2), LDHC(5), LDHD(1), MDH1(3), MDH2(3), ME1(20), ME2(2), ME3(8), PC(14), PCK1(25), PCK2(6), PDHA1(4), PDHA2(20), PDHB(1), PKLR(13), PKM2(7)	19189602	268	128	259	147	170	18	18	32	29	1	0.355	1.000	1.000
212	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(3), CCR3(10), CFL1(2), GNAQ(6), GNAS(25), GNB1(1), HRAS(3), LIMK1(5), MAP2K1(14), MAPK1(4), MAPK3(4), MYL2(9), NOX1(13), PIK3C2G(53), PLCB1(54), PPP1R12B(7), PRKCA(8), PTK2(7), RAF1(10), ROCK2(11)	10245148	249	127	218	95	168	13	7	35	26	0	0.0124	1.000	1.000
213	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(6), ACAA2(1), ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1B10(9), AKR1C4(10), AKR1D1(19), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), BAAT(13), CEL(13), CYP27A1(3), CYP7A1(8), HADHB(5), HSD3B7(5), LIPA(5), RDH11(1), RDH12(2), RDH13(3), SLC27A5(9), SOAT1(3), SOAT2(5), SRD5A1(2), SRD5A2(6)	12990838	272	126	245	122	180	26	21	21	24	0	0.00246	1.000	1.000
214	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(7), ABO(5), B3GALNT1(6), B3GALT1(14), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALNT1(5), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT6(2), FUT1(3), FUT2(3), FUT3(8), FUT4(4), FUT5(8), FUT6(4), FUT7(2), FUT9(30), PIGA(1), PIGB(3), PIGC(2), PIGF(2), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(1), PIGN(3), PIGO(12), PIGQ(9), PIGS(1), PIGT(1), PIGU(7), PIGV(8), PIGX(2), PIGZ(3), ST3GAL1(7), ST3GAL2(1), ST3GAL3(2), ST3GAL4(2), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(6), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(10), UGCG(1)	19806620	257	126	250	137	148	26	13	41	29	0	0.171	1.000	1.000
215	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(36), AR(10), ESR1(6), ESR2(9), ESRRA(3), HNF4A(20), NPM1(2), NR0B1(3), NR1D1(1), NR1D2(10), NR1H2(4), NR1H3(3), NR1I2(4), NR1I3(6), NR2C2(1), NR2E1(5), NR2F1(8), NR2F2(2), NR2F6(1), NR3C1(7), NR4A1(4), NR4A2(4), NR5A1(9), NR5A2(21), PGR(16), PPARA(7), PPARD(3), PPARG(14), RARA(4), RARB(9), RARG(3), ROR1(15), RORA(5), RORC(13), RXRA(4), RXRB(4), RXRG(6), THRA(2), THRB(18), VDR(3)	17081912	305	124	291	145	211	27	8	22	37	0	0.0135	1.000	1.000
216	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(14), ALOX12(6), ALOX15(10), ALOX5(12), CBR3(1), CYP4F2(16), CYP4F3(24), EPX(9), GGT1(8), LPO(20), LTA4H(5), MPO(11), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PRDX1(3), PRDX2(3), PRDX6(4), PTGDS(3), PTGES2(1), PTGIS(17), PTGS1(20), PTGS2(13), TBXAS1(16), TPO(47)	11416448	317	124	308	162	218	27	5	25	41	1	0.00196	1.000	1.000
217	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(4), AKT2(8), AKT3(3), ARHGEF11(20), BCL2(2), CDC42(2), DLG4(6), GNA13(1), LPA(55), MAP2K4(4), MAP3K1(4), MAP3K5(23), MAPK8(1), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(2), PHKA2(9), PI3(6), PIK3CB(14), PLD1(13), PLD2(8), PLD3(1), PTK2(7), RDX(3), ROCK1(7), ROCK2(11), SERPINA4(20), SRF(3), TBXA2R(4)	20055640	256	124	242	136	145	22	10	41	38	0	0.675	1.000	1.000
218	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(6), C1QB(7), C1R(16), C1S(20), C3(48), C5(21), C6(72), C7(47), C8A(43), C9(22)	7082722	302	123	268	113	229	11	5	25	30	2	0.000164	1.000	1.000
219	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(27), ATP4A(16), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(3), ATP5H(3), ATP5J(2), ATP6AP1(3), ATP6V0A1(12), ATP6V0A2(5), ATP6V0A4(22), ATP6V0D1(1), ATP6V0D2(10), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), COX10(6), COX15(3), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(4), LHPP(1), NDUFA10(4), NDUFA4(1), NDUFA9(2), NDUFAB1(1), NDUFB2(2), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFB9(8), NDUFS1(2), NDUFS2(3), NDUFS3(5), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(3), NDUFV2(1), NDUFV3(3), PPA1(1), PPA2(4), SDHA(3), SDHC(3), SDHD(1), TCIRG1(5), UQCRC1(4), UQCRC2(3), UQCRFS1(2)	22938595	264	123	251	126	152	22	13	38	38	1	0.0812	1.000	1.000
220	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(5), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(9), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), BBOX1(6), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(10), EHMT2(11), GCDH(6), HADH(2), HADHA(6), HSD17B10(2), HSD17B4(6), HSD3B7(5), NSD1(21), OGDH(8), OGDHL(42), PIPOX(6), PLOD1(5), PLOD2(6), PLOD3(4), RDH11(1), RDH12(2), RDH13(3), SETD1A(23), SETD7(1), SETDB1(11), SHMT1(2), SHMT2(3), SUV39H1(1), SUV39H2(2), TMLHE(2)	23691176	278	123	267	131	176	23	16	36	27	0	0.0773	1.000	1.000
221	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(22), ACY3(4), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(9), ALDH9A1(2), AMDHD1(5), AOC2(9), AOC3(10), ASPA(3), CARM1(4), CNDP1(8), DDC(14), FTCD(3), HAL(14), HARS(6), HARS2(4), HDC(24), HEMK1(4), HNMT(2), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(7), METTL6(1), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), PRPS1(2), PRPS2(2), UROC1(14), WBSCR22(1)	16182357	266	123	257	165	169	24	19	21	32	1	0.471	1.000	1.000
222	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(9), ALPL(11), ALPP(10), ALPPL2(12), ASCC3(13), ATP13A2(12), DDX18(5), DDX23(6), DDX4(12), DDX41(7), DDX47(1), DDX50(4), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHFR(2), DHX58(4), ENTPD7(2), EP400(27), ERCC2(3), ERCC3(6), FPGS(3), GGH(3), IFIH1(12), MOV10L1(25), NUDT5(1), NUDT8(2), QDPR(3), RAD54B(8), RUVBL2(5), SETX(19), SKIV2L2(6), SMARCA2(14), SMARCA5(5), SPR(4)	25562315	273	123	262	143	174	16	17	28	38	0	0.453	1.000	1.000
223	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(22), AGXT(10), AGXT2(24), ALAS1(2), ALAS2(5), AMT(1), AOC2(9), AOC3(10), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CPT1B(8), CTH(1), DAO(11), DLD(3), DMGDH(15), GAMT(4), GARS(6), GATM(6), GCAT(4), GLDC(5), MAOA(4), MAOB(13), PEMT(2), PISD(2), PLCB2(12), PLCG1(8), PLCG2(27), PSPH(2), SARDH(20), SARS(5), SHMT1(2), SHMT2(3), TARS(5)	17200859	279	122	268	159	191	17	14	21	36	0	0.180	1.000	1.000
224	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(9), ACAA1(6), ACAA2(1), ACADM(4), ACADS(5), ACAT2(1), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH6A1(4), ALDH7A1(9), ALDH9A1(2), AOX1(26), AUH(1), BCAT1(13), BCAT2(1), BCKDHA(2), BCKDHB(2), DBT(3), DLD(3), ECHS1(3), EHHADH(6), HADH(2), HADHA(6), HADHB(5), HIBADH(8), HIBCH(1), HMGCL(4), HMGCS1(3), HMGCS2(21), HSD17B10(2), HSD17B4(6), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(6), OXCT1(4), OXCT2(5), PCCA(4), PCCB(3)	17678628	227	122	216	101	139	18	16	28	26	0	0.142	1.000	1.000
225	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(22), AGXT(10), AGXT2(24), AKR1B10(9), ALAS1(2), ALAS2(5), AMT(1), AOC2(9), AOC3(10), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CTH(1), DAO(11), DLD(3), DMGDH(15), GAMT(4), GARS(6), GATM(6), GCAT(4), GLDC(5), GNMT(1), HSD3B7(5), MAOA(4), MAOB(13), PEMT(2), PHGDH(12), PIPOX(6), PISD(2), PSAT1(3), PSPH(2), RDH11(1), RDH12(2), RDH13(3), SARDH(20), SARS(5), SARS2(4), SDS(2), SHMT1(2), SHMT2(3), TARS(5), TARS2(7)	17485778	279	121	266	157	188	17	12	22	40	0	0.241	1.000	1.000
226	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(6), ARRB2(6), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CLCA1(6), CLCA2(10), CLCA4(29), CNGA3(26), CNGA4(18), CNGB1(21), GNAL(2), GUCA1A(6), GUCA1B(2), GUCA1C(7), PDC(6), PDE1C(52), PRKACA(3), PRKACB(4), PRKACG(11), PRKG1(14), PRKG2(16), PRKX(3)	12372668	286	121	267	154	193	22	9	29	33	0	0.123	1.000	1.000
227	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CDK5(6), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(4), MYL2(9), MYLK(46), NCF2(9), PAK1(4), PDGFRA(34), PIK3CA(10), PIK3R1(2), PLD1(13), PPP1R12B(7), RAC1(20), RALBP1(3), RPS6KB1(3), TRIO(23), VAV1(19), WASF1(4)	14338517	233	121	212	114	151	13	10	28	30	1	0.273	1.000	1.000
228	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(6), ARG1(2), ARG2(2), ASL(6), ASS1(8), CKM(3), CKMT1A(1), CKMT2(5), CPS1(26), DAO(11), EPRS(13), GAMT(4), GATM(6), GLUD1(2), GLUD2(4), GOT1(6), GOT2(6), LAP3(1), NOS1(74), NOS3(19), OAT(4), OTC(4), P4HA1(10), P4HA2(6), P4HA3(12), PRODH(2), PYCR1(1), PYCR2(2), RARS(7), RARS2(5)	14666350	258	120	244	130	172	26	10	18	32	0	0.0739	1.000	1.000
229	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(9), ADRA1B(4), ADRA1D(5), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(3), CHRM1(5), CHRM2(25), CHRM3(26), CHRM4(6), CHRM5(7), DRD1(9), DRD2(14), DRD3(6), DRD4(1), DRD5(25), HRH1(14), HRH2(3), HTR1A(10), HTR1B(1), HTR1D(6), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(13), HTR4(9), HTR5A(19), HTR6(1), HTR7(9)	10355236	269	120	247	208	174	33	9	26	27	0	0.101	1.000	1.000
230	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(20), ACAT2(1), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(2), LDHA(4), LDHB(2), LDHC(5), LDHD(1), MDH1(3), MDH2(3), ME1(20), ME2(2), ME3(8), PC(14), PCK1(25), PDHA1(4), PDHA2(20), PDHB(1), PKLR(13), PKM2(7)	15167279	222	120	215	119	146	16	12	24	23	1	0.353	1.000	1.000
231	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(6), ACAA2(1), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH6(14), ADH7(16), ADHFE1(6), AKR1C4(10), AKR1D1(19), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), BAAT(13), CEL(13), CYP27A1(3), CYP7A1(8), HADHB(5), SOAT2(5), SRD5A1(2), SRD5A2(6)	9546430	237	119	212	100	157	19	15	22	24	0	0.00211	1.000	1.000
232	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(8), ACTN2(20), ACTN3(3), BCAR1(5), BCR(15), CAPN1(4), CAPNS1(3), CAPNS2(1), CAV1(1), CRKL(3), CSK(1), FYN(7), GRB2(2), HRAS(3), ITGA1(24), ITGB1(4), JUN(1), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MAPK8(1), PPP1R12B(7), PTK2(7), PXN(2), RAF1(10), RAP1A(2), ROCK1(7), SHC1(2), SOS1(10), SRC(2), TLN1(12), VCL(8), ZYX(8)	19112821	214	119	204	99	114	24	12	35	28	1	0.114	1.000	1.000
233	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(2), CHUK(2), DAXX(9), EGF(21), EGFR(25), ETS1(4), ETS2(8), FOS(2), HOXA7(2), HRAS(3), IKBKB(4), JUN(1), MAP2K1(14), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K14(6), MAP3K5(23), MAPK1(4), MAPK13(5), MAPK14(5), MAPK3(4), MAPK8(1), NFKB1(6), NFKBIA(2), PRKCA(8), PRKCD(5), PRKCE(6), PRKCG(16), PRKCH(9), PRKCQ(20), RAF1(10), RELA(4), RIPK1(3), SP1(5), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2)	20046858	274	118	262	159	161	25	8	37	43	0	0.733	1.000	1.000
234	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(25), ELK1(3), GNAS(25), GNB1(1), GRB2(2), HRAS(3), IGF1R(14), ITGB1(4), KLK2(5), MAP2K1(14), MAP2K2(5), MAPK1(4), MAPK3(4), MKNK1(6), MKNK2(3), MYC(5), NGFR(8), PDGFRA(34), PTPRR(30), RAF1(10), RPS6KA1(8), RPS6KA5(7), SHC1(2), SOS1(10), SRC(2), STAT3(9)	13482907	244	117	228	111	149	25	11	41	18	0	0.122	1.000	1.000
235	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(34), CALM1(1), CALM2(1), ELK1(3), FOS(2), GNAI1(2), GNAQ(6), GNAS(25), GNB1(1), HRAS(3), JUN(1), MAP2K1(14), MAPK3(4), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), RAF1(10), RPS6KA3(1), SYT1(23)	14250284	239	117	222	127	145	25	14	28	27	0	0.617	1.000	1.000
236	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(5), AARS2(3), ABAT(9), ACY3(4), ADSL(5), ADSS(1), ADSSL1(7), AGXT(10), AGXT2(24), ASL(6), ASNS(8), ASPA(3), ASRGL1(6), ASS1(8), CAD(18), CRAT(5), DARS(4), DARS2(3), DDO(8), DLAT(4), DLD(3), GAD1(13), GAD2(9), GOT1(6), GOT2(6), GPT(3), GPT2(2), NARS(2), NARS2(6), PC(14), PDHA1(4), PDHA2(20), PDHB(1)	15525618	230	117	218	116	157	21	12	18	22	0	0.0869	1.000	1.000
237	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(48), C5(21), C6(72), C7(47), C8A(43), C9(22)	5089848	253	116	220	90	192	6	4	22	27	2	0.000456	1.000	1.000
238	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(6), APAF1(6), ARHGDIB(4), BAG4(3), BCL2(2), BIRC2(6), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CRADD(2), CYCS(1), DAXX(9), DFFA(2), DFFB(2), GSN(6), LMNA(7), LMNB1(1), LMNB2(4), MAP2K7(5), MAP3K1(4), MAP3K14(6), MAP3K5(23), MAPK8(1), MDM2(1), NFKB1(6), NFKBIA(2), NUMA1(9), PAK2(7), PRKCD(5), PRKDC(19), PSEN1(1), PSEN2(2), PTK2(7), RASA1(4), RB1(10), RELA(4), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2)	28281841	238	116	232	123	123	25	15	36	37	2	0.523	1.000	1.000
239	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(25), ATF2(6), AXIN1(9), BMP10(14), BMP2(7), BMP4(4), BMP5(32), BMP7(5), BMPR1A(2), BMPR2(6), CHRD(21), CTNNB1(14), FZD1(5), GATA4(4), GSK3B(3), MAP3K7(1), MEF2C(4), MYL2(9), NKX2-5(1), NOG(2), NPPA(4), NPPB(6), RFC1(5), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TGFBR3(8), WNT1(2)	14832902	218	115	201	96	140	18	9	20	31	0	0.186	1.000	1.000
240	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(3), ARSE(5), B4GALT6(2), CERK(1), DEGS1(2), DEGS2(6), ENPP7(7), GAL3ST1(10), GALC(3), GBA(7), GLA(2), GLB1(9), LCT(51), NEU1(6), NEU2(17), NEU3(4), NEU4(16), PPAP2A(1), PPAP2B(11), PPAP2C(8), SGMS1(18), SGMS2(1), SGPP1(2), SGPP2(6), SMPD1(2), SMPD2(2), SMPD3(9), SMPD4(5), SPHK1(2), SPHK2(7), SPTLC1(1), SPTLC2(6), UGCG(1), UGT8(8)	14524702	241	115	234	145	168	15	6	28	24	0	0.587	1.000	1.000
241	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(4), ARSB(2), FUCA1(3), GALNS(5), GBA(7), GLB1(9), GNS(1), GUSB(5), HEXA(6), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(51), MAN2B1(8), MAN2B2(10), MAN2C1(7), MANBA(8), NAGLU(4), NEU1(6), NEU2(17), NEU3(4), NEU4(16), SPAM1(27)	13995154	240	115	236	112	169	19	5	23	24	0	0.0340	1.000	1.000
242	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(6), BAK1(1), BAX(3), BCL2(2), BIRC2(6), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), FAS(6), FASLG(15), GZMB(3), JUN(1), MAP2K4(4), MAP3K1(4), MAP3K14(6), MAPK10(9), MCL1(3), MDM2(1), MYC(5), NFKB1(6), NFKBIA(2), PARP1(7), PRF1(11), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFSF10(8), TP53(51), TRAF1(6), TRAF2(2)	15257131	210	114	198	72	115	17	15	21	41	1	0.00221	1.000	1.000
243	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(22), ALDH1A3(2), ALDH3A1(8), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(10), DDC(14), EPX(9), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(11), PRDX1(3), PRDX2(3), PRDX6(4), TAT(19), TPO(47)	8975875	228	114	221	140	160	19	10	13	26	0	0.164	1.000	1.000
244	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(7), ANXA2(8), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(5), CYP11A1(14), EDN1(9), EDNRA(10), EDNRB(7), HPGD(1), HSD11B1(14), HSD11B2(3), PLA2G4A(15), PRL(3), PTGDR(11), PTGDS(3), PTGER2(7), PTGER4(2), PTGFR(21), PTGIR(5), PTGIS(17), PTGS1(20), PTGS2(13), S100A6(1), SCGB1A1(1), TBXAS1(16)	8387430	220	114	211	87	150	21	6	20	23	0	6.57e-05	1.000	1.000
245	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(11), F2R(8), F2RL3(4), GNAI1(2), GNB1(1), HRAS(3), ITGA1(24), ITGB1(4), MAP2K1(14), MAPK1(4), MAPK3(4), PLA2G4A(15), PLCB1(54), PRKCA(8), PTGS1(20), PTK2(7), RAF1(10), SRC(2), SYK(14), TBXAS1(16)	9966043	225	114	207	95	149	16	6	28	26	0	0.0265	1.000	1.000
246	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(9), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(2), EIF2S1(1), EIF2S3(1), ELAVL1(1), FLT1(38), FLT4(30), HIF1A(4), HRAS(3), KDR(55), NOS3(19), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), PTK2(7), PXN(2), SHC1(2), VHL(4)	13977944	212	114	200	107	138	19	4	27	23	1	0.388	1.000	1.000
247	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(8), AGTR1(10), ATF2(6), CALM1(1), CALM2(1), EGFR(25), ELK1(3), GNAQ(6), GRB2(2), HRAS(3), JUN(1), MAP2K1(14), MAP2K2(5), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(4), MAPK8(1), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), PAK1(4), PRKCA(8), PTK2(7), PTK2B(10), RAC1(20), RAF1(10), SHC1(2), SOS1(10), SRC(2), SYT1(23)	13690088	213	113	186	108	136	16	10	31	20	0	0.528	1.000	1.000
248	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(3), ALG10(6), ALG10B(4), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG5(3), ALG6(2), ALG8(7), ALG9(6), B4GALT1(2), B4GALT2(2), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(8), GANAB(5), MAN1A1(18), MAN1A2(7), MAN1B1(3), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(2), MGAT3(11), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(12), RFT1(5), RPN2(4), ST6GAL1(6), STT3B(5)	17333447	194	113	189	99	115	20	13	20	26	0	0.200	1.000	1.000
249	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(5), CHUK(2), ELK1(3), FOS(2), IKBKB(4), IRAK1(5), JUN(1), LY96(4), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K14(6), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(3), NFKB1(6), NFKBIA(2), PPARA(7), RELA(4), TIRAP(1), TLR10(12), TLR2(15), TLR3(11), TLR4(41), TLR6(7), TLR7(17), TLR9(18), TOLLIP(1), TRAF6(4)	14856275	207	113	200	104	136	21	10	22	18	0	0.216	1.000	1.000
250	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(3), GHR(40), GRB2(2), HRAS(3), INSR(26), IRS1(5), JAK2(8), MAP2K1(14), MAPK1(4), MAPK3(4), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), PTPN6(5), RAF1(10), RPS6KA1(8), SHC1(2), SLC2A4(9), SOCS1(1), SOS1(10), SRF(3), STAT5A(3), STAT5B(6)	13589375	194	112	178	92	116	14	11	33	19	1	0.262	1.000	1.000
251	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(22), ALDH1A3(2), ALDH3A1(8), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(10), DDC(14), EPX(9), ESCO1(2), ESCO2(4), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(11), PNPLA3(3), PRDX6(4), SH3GLB1(2), TAT(19), TPO(47)	14035363	233	112	226	148	162	18	13	15	25	0	0.723	1.000	1.000
252	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(10), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), CYP2C19(75), CYP2C9(38), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), HADHA(6), PNPLA3(3), SH3GLB1(2), YOD1(1)	12707526	214	112	198	127	136	20	13	18	27	0	0.769	1.000	1.000
253	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(5), AARS2(3), CARS(8), CARS2(3), DARS(4), DARS2(3), EARS2(2), EPRS(13), FARS2(6), FARSA(8), FARSB(5), GARS(6), HARS(6), HARS2(4), IARS(8), IARS2(16), KARS(3), LARS(12), LARS2(5), MARS(7), MARS2(4), MTFMT(2), NARS(2), NARS2(6), QARS(6), RARS(7), RARS2(5), SARS(5), SARS2(4), TARS(5), TARS2(7), VARS(18), VARS2(7), WARS(5), WARS2(4), YARS(3), YARS2(2)	22411204	219	112	208	107	129	21	9	23	36	1	0.308	1.000	1.000
254	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(3), ACTR3(2), ARHGAP1(3), ARHGAP4(4), ARHGAP5(13), ARHGAP6(11), ARHGEF1(1), ARHGEF11(20), ARHGEF5(18), ARPC1B(3), ARPC2(1), ARPC3(1), BAIAP2(7), CFL1(2), DIAPH1(9), GSN(6), LIMK1(5), MYL2(9), MYLK(46), OPHN1(4), PIP5K1A(6), PIP5K1B(21), PPP1R12B(7), ROCK1(7), SRC(2), TLN1(12), VCL(8)	18426178	231	112	221	110	162	13	9	24	23	0	0.0458	1.000	1.000
255	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(16), DLG4(6), EPHB2(34), F2(11), F2RL1(16), F2RL2(8), F2RL3(4), JUN(1), MAP2K5(4), MAPK1(4), MAPK7(4), MAPK8(1), MYEF2(4), PLD1(13), PLD2(8), PLD3(1), PTK2(7), RAF1(10), RASAL1(18), SRC(2), TEC(13), VAV1(19)	11210496	204	112	194	127	115	21	6	37	25	0	0.857	1.000	1.000
256	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(6), ACAA2(1), ACADL(5), ACADM(4), ACADS(5), ACADSB(5), ACAT2(1), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH6A1(4), ALDH9A1(2), AOX1(26), BCAT1(13), BCKDHA(2), BCKDHB(2), ECHS1(3), EHHADH(6), HADHA(6), HADHB(5), HIBADH(8), HMGCL(4), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(6), OXCT1(4), PCCA(4), PCCB(3), SDS(2)	14799563	192	112	183	89	119	14	11	22	26	0	0.233	1.000	1.000
257	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(15), ATR(23), BRCA1(15), BRCA2(22), CHEK1(2), CHEK2(2), FANCA(8), FANCC(3), FANCD2(12), FANCE(4), FANCF(1), FANCG(7), HUS1(2), MRE11A(6), RAD1(2), RAD17(6), RAD50(6), RAD9A(6), TP53(51), TREX1(1)	18074157	194	111	181	67	116	7	7	21	42	1	0.0810	1.000	1.000
258	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(34), AKT1(4), GNAI1(2), GNB1(1), ITGAV(9), ITGB3(15), MAPK1(4), MAPK3(4), PDGFA(1), PDGFRA(34), PIK3CA(10), PIK3R1(2), PLCB1(54), PRKCA(8), PTK2(7), RAC1(20), SMPD1(2), SMPD2(2), SPHK1(2), SRC(2)	11277247	217	111	197	96	154	12	6	25	19	1	0.0344	1.000	1.000
259	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(19), CALCR(18), CALCRL(19), CD97(7), CRHR1(7), CRHR2(4), ELTD1(27), EMR1(32), EMR2(5), GHRHR(5), GIPR(3), GLP1R(13), GLP2R(15), GPR64(4), LPHN1(7), LPHN2(46), LPHN3(22), SCTR(6), VIPR1(7), VIPR2(7)	10798795	273	111	253	174	195	19	7	15	37	0	0.231	1.000	1.000
260	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(6), CDC42(2), DAXX(9), DDIT3(2), ELK1(3), GRB2(2), HMGN1(2), HRAS(3), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K5(23), MAP3K7(1), MAP3K9(26), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), MKNK1(6), MYC(5), PLA2G4A(15), RAC1(20), RIPK1(3), RPS6KA5(7), SHC1(2), STAT1(5), TGFB1(2), TGFB2(3), TGFB3(3), TRAF2(2)	14893986	192	111	176	67	125	13	6	27	21	0	0.0115	1.000	1.000
261	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(15), ATR(23), BRCA1(15), CDC25A(8), CDC25B(4), CDC25C(5), CDC34(3), CDKN1A(3), CHEK1(2), CHEK2(2), EP300(18), MDM2(1), MYT1(21), PRKDC(19), RPS6KA1(8), TP53(51), WEE1(2), YWHAQ(3)	17181818	203	110	190	70	119	13	11	24	35	1	0.0350	1.000	1.000
262	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(10), EGF(21), EGFR(25), GRB2(2), HRAS(3), MAP2K1(14), MAPK1(4), MAPK3(4), PTPRB(89), RAF1(10), RASA1(4), SHC1(2), SOS1(10), SPRY1(9), SPRY2(4), SPRY3(12), SPRY4(2), SRC(2)	10229715	227	110	205	95	151	18	5	28	25	0	0.119	1.000	1.000
263	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(4), AKT2(8), AKT3(3), CISH(4), GRB2(2), IARS(8), IL13RA1(3), IL2RG(3), IL4(1), IL4R(16), INPP5D(37), JAK1(6), JAK2(8), JAK3(11), NR0B2(6), PI3(6), PIK3CA(10), PPP1R13B(9), RPS6KB1(3), SERPINA4(20), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT6(8), TYK2(8)	15076025	211	110	201	95	139	14	8	27	23	0	0.176	1.000	1.000
264	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(4), BCL2(2), EGFR(25), IGF1R(14), MYC(5), POLR2A(13), PRKCA(8), RB1(10), TEP1(34), TERF1(2), TERT(9), TNKS(9), TP53(51), XRCC5(2)	11532160	188	110	174	77	102	14	12	19	38	3	0.0227	1.000	1.000
265	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(13), DIAPH1(9), FYN(7), GSN(6), HRAS(3), ITGA1(24), ITGB1(4), MAP2K1(14), MAPK1(4), MAPK3(4), MYL2(9), MYLK(46), PIK3CA(10), PIK3R1(2), PTK2(7), PXN(2), RAF1(10), ROCK1(7), SHC1(2), SRC(2), TLN1(12)	15273129	197	109	179	87	122	13	7	32	22	1	0.149	1.000	1.000
266	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), DAG1(9), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), NFAT5(8), PDE6A(14), PDE6B(16), PDE6C(24), PDE6D(2), PDE6G(2), SLC6A13(30), TF(16)	14580747	222	109	208	125	154	11	7	18	32	0	0.0962	1.000	1.000
267	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(24), CD2(27), CD33(21), CD5(7), CD7(1), CSF2(2), IFNA1(1), IFNB1(6), IFNG(4), IL10(3), IL12A(4), IL12B(3), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(23), TLR2(15), TLR4(41), TLR7(17), TLR9(18)	7604075	227	108	211	114	162	19	10	13	23	0	0.000296	1.000	1.000
268	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(4), APC(25), AXIN1(9), CCND1(2), CD14(5), CTNNB1(14), FZD1(5), GJA1(9), GNAI1(2), GSK3B(3), IRAK1(5), LBP(9), LEF1(3), LY96(4), MYD88(3), NFKB1(6), PDPK1(3), PIK3CA(10), PIK3R1(2), RELA(4), TIRAP(1), TLR4(41), TOLLIP(1), WNT1(2)	12469085	172	108	163	88	107	14	10	20	20	1	0.603	1.000	1.000
269	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(5), CRK(3), CXCL12(3), CXCR4(3), GNAI1(2), GNAQ(6), GNB1(1), HRAS(3), MAP2K1(14), MAPK1(4), MAPK3(4), NFKB1(6), PIK3C2G(53), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), PTK2(7), PTK2B(10), PXN(2), RAF1(10), RELA(4)	11236743	168	107	147	88	108	12	6	26	15	1	0.539	1.000	1.000
270	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(56), CR2(34), FCGR2B(4), HLA-DRA(12), ICAM1(2), ITGAL(28), ITGB2(16), PTPRC(35)	6172504	191	106	181	69	124	15	7	15	29	1	0.00618	1.000	1.000
271	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(4), EIF4A1(4), EIF4A2(4), EIF4EBP1(1), EIF4G1(18), EIF4G2(4), EIF4G3(17), GHR(40), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(4), MKNK1(6), PABPC1(5), PDK2(4), PDPK1(3), PIK3CA(10), PIK3R1(2), PRKCA(8), PTEN(23), RPS6KB1(3)	11584805	174	105	164	56	95	16	11	19	32	1	0.0164	1.000	1.000
272	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(22), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(2), AOC2(9), AOC3(10), ASPA(3), CNDP1(8), DDC(14), HAL(14), HARS(6), HDC(24), HNMT(2), MAOA(4), MAOB(13), PRPS1(2), PRPS2(2)	9964656	196	105	187	118	125	12	13	18	27	1	0.380	1.000	1.000
273	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(22), ACY1(2), ADC(5), AGMAT(4), ALDH18A1(7), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), AOC2(9), AOC3(10), ARG1(2), ARG2(2), ASL(6), ASS1(8), CPS1(26), GATM(6), MAOA(4), MAOB(13), NAGS(1), ODC1(3), OTC(4), SMS(4), SRM(1)	11957482	181	105	175	102	104	16	12	21	28	0	0.385	1.000	1.000
274	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(37), ACE2(5), AGT(8), AGTR1(10), AGTR2(9), ANPEP(24), CMA1(5), CPA3(22), CTSA(5), CTSG(4), ENPEP(44), LNPEP(11), MAS1(4), MME(23), NLN(4), REN(11), THOP1(6)	8638071	232	105	216	112	162	19	11	11	29	0	0.00854	1.000	1.000
275	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(43), ITGAL(28), ITGAM(23), ITGB1(4), ITGB2(16), SELE(33), SELL(10), SELP(39)	6467156	203	105	192	67	152	4	6	15	26	0	0.000169	1.000	1.000
276	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(5), CALM1(1), CALM2(1), CRKL(3), GNAQ(6), GRB2(2), HRAS(3), JUN(1), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(4), MAPK8(1), PAK1(4), PLCG1(8), PRKCA(8), PTK2B(10), RAC1(20), RAF1(10), SHC1(2), SOS1(10), SRC(2), SYT1(23)	11653032	168	105	143	81	100	15	8	29	16	0	0.394	1.000	1.000
277	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(4), CAPN2(5), CAPNS1(3), CAPNS2(1), CXCR3(4), EGF(21), EGFR(25), HRAS(3), ITGA1(24), ITGB1(4), MAPK1(4), MAPK3(4), MYL2(9), MYLK(46), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTK2(7), PXN(2), TLN1(12)	13302110	210	104	201	113	137	11	9	22	31	0	0.229	1.000	1.000
278	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(15), CARM1(4), CCND1(2), CREBBP(24), EP300(18), ERCC3(6), ESR1(6), GRIP1(12), GTF2A1(2), GTF2E1(3), GTF2F1(5), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(2), MEF2C(4), NCOR2(26), NR0B1(3), NRIP1(8), PELP1(12), POLR2A(13), TBP(4)	18626930	195	103	194	84	128	9	12	30	16	0	0.145	1.000	1.000
279	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(25), AXIN1(9), CREBBP(24), CTNNB1(14), EP300(18), FZD1(5), GSK3B(3), HDAC1(2), LDB1(3), LEF1(3), PITX2(5), TRRAP(46), WNT1(2)	13630103	159	103	153	84	83	16	12	24	24	0	0.822	1.000	1.000
280	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(4), CABIN1(16), CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), HDAC5(6), IGF1(10), IGF1R(14), INSR(26), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), MYOD1(1), NFATC1(16), NFATC2(11), PIK3CA(10), PIK3R1(2), PPP3CA(5), PPP3CB(3), PPP3CC(2), SYT1(23)	14275766	194	102	182	97	126	16	11	23	17	1	0.184	1.000	1.000
281	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(34), AKT1(4), BAX(3), BCL2(2), CSF2RB(24), IGF1(10), IGF1R(14), IL3(3), IL3RA(7), KIT(12), KITLG(11), PIK3CA(10), PIK3R1(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	8977895	164	101	157	84	101	18	9	14	21	1	0.175	1.000	1.000
282	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(34), AKT1(4), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), GNAS(25), GRB2(2), HRAS(3), MAPK1(4), MAPK14(5), MAPK3(4), PIK3CA(10), PIK3R1(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8), RAC1(20), RPS6KA1(8), RPS6KA5(7), SOS1(10)	11866404	197	101	180	105	125	19	9	24	19	1	0.603	1.000	1.000
283	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(8), EXTL1(2), EXTL3(12), GLCE(8), HS2ST1(1), HS3ST1(10), HS3ST2(9), HS3ST3A1(6), HS3ST3B1(2), HS3ST5(8), HS6ST1(2), HS6ST2(3), HS6ST3(15), NDST1(6), NDST2(2), NDST3(25), NDST4(52)	8359735	173	101	167	94	112	12	6	20	23	0	0.237	1.000	1.000
284	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(9), ACACA(20), ACACB(23), ACADM(4), ACAT2(1), ACSS1(2), ACSS2(4), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH6A1(4), ALDH7A1(9), ALDH9A1(2), ECHS1(3), EHHADH(6), HADHA(6), HIBCH(1), LDHA(4), LDHAL6A(4), LDHAL6B(6), LDHB(2), LDHC(5), MCEE(2), MLYCD(2), MUT(6), PCCA(4), PCCB(3), SUCLG1(3), SUCLG2(2)	16322041	168	101	162	96	97	13	17	21	20	0	0.721	1.000	1.000
285	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ACTG2(6), ADCY3(3), ADCY9(10), AK1(1), ARF4(2), ARF5(2), ARF6(1), ARL4D(2), ATP6V0A1(12), ATP6V0A2(5), ATP6V0A4(22), ATP6V0D1(1), ATP6V0D2(10), ATP6V0E1(1), ATP6V1A(2), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), ERO1L(5), GNAS(25), PDIA4(5), PLCG1(8), PLCG2(27), PRKCA(8), SEC61A1(3), SEC61A2(4), TRIM23(2)	15191075	199	101	192	125	129	12	9	22	27	0	0.614	1.000	1.000
286	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(27), ATP4B(1), ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(22), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), ATP7A(12), ATP7B(21), COX10(6), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX8A(1), NDUFA10(4), NDUFA4(1), NDUFB2(2), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(3), NDUFV2(1), PPA2(4), SDHA(3), SHMT1(2), UQCRC1(4), UQCRFS1(2)	15711434	182	101	180	110	110	13	15	23	20	1	0.766	1.000	1.000
287	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(5), BLVRA(2), BLVRB(1), CP(12), CPOX(4), EPRS(13), FECH(3), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(4), UGT1A1(77), UGT2B15(31), UGT2B4(34), UROS(1)	11315380	197	101	183	83	137	16	7	13	23	1	0.0167	1.000	1.000
288	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(4), ATF1(4), CDC42(2), CREB3(1), CREB5(9), DUSP1(1), DUSP10(7), EEF2K(6), ELK1(3), HSPB1(2), IL1R1(13), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP3K10(9), MAP3K4(17), MAP3K5(23), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(6), MKNK2(3), MYEF2(4), NFKB1(6), NR2C2(1), SRF(3), TRAF6(4)	13629238	166	101	160	95	107	15	3	22	19	0	0.707	1.000	1.000
289	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(10), EEF1B2(1), EEF1D(6), EEF1G(5), EEF2(4), EEF2K(6), EIF1AX(3), EIF2AK1(4), EIF2AK2(6), EIF2AK3(16), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(2), EIF2S1(1), EIF2S3(1), EIF4A1(4), EIF4A2(4), EIF4EBP1(1), EIF4G1(18), EIF4G3(17), EIF5(2), EIF5B(3), ETF1(2), GSPT2(9), KIAA0664(5), PABPC1(5), PABPC3(8), PAIP1(8), SLC35A4(4)	17881388	161	101	160	81	90	15	12	21	23	0	0.678	1.000	1.000
290	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(4), ACP2(2), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(10), ALPPL2(12), CMBL(5), CYP3A4(20), CYP3A43(19), CYP3A7(30), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), PON1(21), PON2(2)	7362111	194	100	183	71	141	10	6	12	25	0	3.38e-05	1.000	1.000
291	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(4), BCL2(2), CBL(10), CFLAR(4), CRKL(3), E2F1(5), FOS(2), GRB2(2), HRAS(3), IL2RA(5), IL2RB(12), IL2RG(3), IRS1(5), JAK1(6), JAK3(11), MAPK1(4), MAPK3(4), MYC(5), NMI(4), PIK3CA(10), PIK3R1(2), PPIA(1), PTPN6(5), RAF1(10), RPS6KB1(3), SHC1(2), SOCS1(1), SOCS3(1), SOS1(10), STAT5A(3), STAT5B(6), SYK(14)	14750528	162	100	160	85	89	16	10	27	19	1	0.632	1.000	1.000
292	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(8), CREBBP(24), CSK(1), GNAS(25), GNB1(1), HLA-DRA(12), LCK(15), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(35), ZAP70(7)	9306331	200	99	191	99	124	22	11	19	24	0	0.199	1.000	1.000
293	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(6), BAX(3), BCL2(2), BCL2A1(2), CASP1(10), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CD40(4), CD40LG(2), CRADD(2), CYCS(1), DAXX(9), DFFA(2), DFFB(2), FAS(6), FASLG(15), IKBKE(10), LTA(4), MCL1(3), NFKB1(6), NFKBIA(2), NGFR(8), NR3C1(7), NTRK1(16), PTPN13(15), RIPK1(3), TFG(2), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5), TRAF6(4)	17730349	194	99	191	108	124	14	8	23	25	0	0.742	1.000	1.000
294	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(8), CREBBP(24), CSK(1), GNAS(25), GNB1(1), HLA-DRA(12), LCK(15), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(35), ZAP70(7)	9306331	200	99	191	99	124	22	11	19	24	0	0.199	1.000	1.000
295	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(6), IKBKB(4), IL1A(5), IL1B(8), IL1R1(13), IL1RAP(3), IL1RN(9), IL6(2), IRAK1(5), IRAK2(15), IRAK3(10), JUN(1), MAP2K3(8), MAP2K6(3), MAP3K1(4), MAP3K14(6), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(3), NFKB1(6), NFKBIA(2), RELA(4), TGFB1(2), TGFB2(3), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4)	12079419	141	99	138	74	89	14	5	14	19	0	0.380	1.000	1.000
296	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(27), F2(11), F2R(8), FGA(41), FGB(10), FGG(10), PLAT(4), PLAU(3), PLG(34), SERPINB2(36), SERPINE1(5)	5471807	190	98	180	71	131	13	10	20	16	0	0.0210	1.000	1.000
297	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(13), BCAT2(1), COASY(6), DPYD(67), DPYS(24), ENPP1(13), ENPP3(13), ILVBL(5), PANK1(3), PANK2(3), PANK3(2), PANK4(6), PPCS(3), UPB1(10), VNN1(7)	7074481	176	98	158	51	130	11	3	18	14	0	1.79e-05	1.000	1.000
298	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(6), AKT1(4), AKT2(8), AKT3(3), DAG1(9), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(11), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PDK1(2), PHKA2(9), PIK3CB(14), PITX2(5), PLD1(13), PLD2(8), PLD3(1), VN1R1(1)	18326221	182	98	173	108	98	18	14	29	23	0	0.546	1.000	1.000
299	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(25), CAMP(2), CASP3(2), CERK(1), CREB3(1), CREB5(9), DAG1(9), EPHB2(34), FOS(2), GNAQ(6), ITPKB(11), JUN(1), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3)	11656134	153	98	148	90	97	11	7	17	21	0	0.825	1.000	1.000
300	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(8), ABAT(9), ACADS(5), ACAT2(1), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH5A1(10), ALDH9A1(2), ECHS1(3), EHHADH(6), GAD1(13), GAD2(9), HADHA(6), HMGCL(4), L2HGDH(3), OXCT1(4), PDHA1(4), PDHA2(20), PDHB(1), SDS(2)	10616341	160	97	153	72	96	17	7	18	22	0	0.0651	1.000	1.000
301	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(7), BAIAP2(7), CASP1(10), CASP3(2), CASP7(4), CASP8(9), GAPDH(2), INSR(26), ITCH(8), MAGI1(31), MAGI2(24), RERE(23), WWP1(5), WWP2(9)	9875104	167	97	161	70	110	11	5	20	20	1	0.173	1.000	1.000
302	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(4), HLA-A(3), IL18(3), ITGB1(4), KLRC1(4), KLRC2(14), KLRC4(6), KLRD1(5), LAT(2), MAP2K1(14), MAPK3(4), PAK1(4), PIK3CA(10), PIK3R1(2), PTK2B(10), PTPN6(5), RAC1(20), SYK(14), VAV1(19)	7598029	147	97	124	77	106	5	2	15	18	1	0.493	1.000	1.000
303	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(7), F2(11), F2R(8), F3(2), F5(36), F7(7), FGA(41), FGB(10), FGG(10), PROC(12), PROS1(18), SERPINC1(8), TFPI(7)	6727303	177	96	163	69	118	20	9	19	11	0	0.0507	1.000	1.000
304	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(10), ACO1(6), ACO2(5), CLYBL(5), CS(2), DLD(3), FH(3), IDH1(16), IDH2(1), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(3), OGDH(8), OGDHL(42), PC(14), PCK1(25), PCK2(6), SDHA(3), SDHC(3), SDHD(1), SUCLG1(3), SUCLG2(2)	12288881	171	96	156	89	117	4	6	24	20	0	0.193	1.000	1.000
305	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(9), ADC(5), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(26), EARS2(2), EPRS(13), GAD1(13), GAD2(9), GCLC(5), GCLM(2), GFPT1(4), GFPT2(8), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), GMPS(6), GOT1(6), GOT2(6), GPT(3), GPT2(2), GSR(2), GSS(8), NADSYN1(4), NAGK(1), QARS(6)	16191353	187	96	180	101	109	23	10	26	19	0	0.414	1.000	1.000
306	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2A2(1), GTF2B(4), GTF2E1(3), GTF2E2(5), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(2), GTF2I(2), GTF2IRD1(10), TAF1(14), TAF13(2), TAF1L(56), TAF2(8), TAF4(10), TAF4B(5), TAF5L(4), TAF6(4), TAF6L(3), TAF7(2), TAF7L(13), TAF9B(1), TBPL1(1), TBPL2(7)	14836617	170	96	166	71	114	12	6	22	16	0	0.215	1.000	1.000
307	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(34), ARHGEF1(1), F2(11), F2R(8), F2RL3(4), GNA12(3), GNA13(1), GNAI1(2), GNAQ(6), GNB1(1), MAP3K7(1), PIK3CA(10), PIK3R1(2), PLCB1(54), PPP1R12B(7), PRKCA(8), PTK2B(10), ROCK1(7)	10583429	170	96	160	86	112	13	8	21	15	1	0.316	1.000	1.000
308	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), JAK1(6), JUN(1), MAP2K1(14), MAP2K4(4), MAP3K1(4), MAPK3(4), MAPK8(1), PDGFA(1), PDGFRA(34), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), RAF1(10), RASA1(4), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(9), STAT5A(3)	14289049	157	95	148	71	84	17	7	33	15	1	0.440	1.000	1.000
309	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(9), ACACA(20), ACADL(5), ACADM(4), ACADSB(5), ACAT2(1), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH6A1(4), ALDH9A1(2), ECHS1(3), EHHADH(6), HADHA(6), LDHA(4), LDHB(2), LDHC(5), MCEE(2), MLYCD(2), MUT(6), PCCA(4), PCCB(3), SDS(2), SUCLG1(3), SUCLG2(2)	13620338	150	95	145	75	92	11	12	18	17	0	0.454	1.000	1.000
310	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(13), ATM(15), BRCA1(15), CDKN1A(3), CHEK1(2), CHEK2(2), JUN(1), MAPK8(1), MDM2(1), MRE11A(6), NFKB1(6), NFKBIA(2), RAD50(6), RBBP8(4), RELA(4), TP53(51), TP73(6)	12159675	138	94	127	45	65	12	7	19	34	1	0.116	1.000	1.000
311	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), EGF(21), EGFR(25), ELK1(3), FOS(2), GRB2(2), HRAS(3), JAK1(6), JUN(1), MAP2K1(14), MAP2K4(4), MAP3K1(4), MAPK3(4), MAPK8(1), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), RAF1(10), RASA1(4), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(9), STAT5A(3)	15346284	168	94	159	84	89	18	8	33	19	1	0.727	1.000	1.000
312	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(3), GPT2(2), MDH1(3), MDH2(3), ME1(20), ME3(8), PGK1(2), PGK2(35), PKLR(13), PKM2(7), TKT(6), TKTL1(3), TKTL2(26), TPI1(1)	8302106	169	94	157	91	128	15	4	10	11	1	0.0288	1.000	1.000
313	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(17), ANAPC10(1), ANAPC2(6), ANAPC4(6), ANAPC5(10), ANAPC7(6), BTRC(4), CDC16(1), CDC20(1), CDC23(4), CDC27(13), CUL1(5), CUL2(4), CUL3(5), FBXW11(6), FBXW7(11), FZR1(7), ITCH(8), SKP2(2), SMURF1(2), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(2), UBE2D1(1), UBE2D3(2), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(5), WWP2(9)	16322900	159	94	153	60	95	6	8	24	25	1	0.208	1.000	1.000
314	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2)	5419203	139	93	120	47	98	9	10	12	10	0	0.000345	1.000	1.000
315	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(13), COASY(6), DPYD(67), DPYS(24), ENPP1(13), ENPP3(13), PANK1(3), PANK2(3), PANK3(2), PANK4(6), PPCS(3), UPB1(10)	5699586	163	93	145	46	118	11	3	18	13	0	0.000109	1.000	1.000
316	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(8), CHAT(17), COMT(3), DBH(15), DDC(14), GAD1(13), GAD2(9), HDC(24), MAOA(4), PAH(12), PNMT(4), SLC18A3(2), TH(12), TPH1(12)	5791894	150	92	141	87	108	12	5	5	20	0	0.112	1.000	1.000
317	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(9), ALDOA(2), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FUK(5), GMDS(5), GMPPA(1), GMPPB(4), HK1(3), HK2(13), HK3(14), HSD3B7(5), KHK(1), LHPP(1), MPI(1), MTMR1(5), MTMR2(2), MTMR6(2), PFKFB1(4), PFKFB2(5), PFKFB3(2), PFKFB4(6), PFKL(4), PFKM(2), PFKP(2), PGM2(7), PMM1(3), PMM2(2), RDH11(1), RDH12(2), RDH13(3), SORD(2), TPI1(1), TSTA3(4)	15120700	148	92	144	102	98	16	10	8	16	0	0.639	1.000	1.000
318	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(2), CREBBP(24), EP300(18), FYN(7), IL2RG(3), IL7(4), IL7R(34), JAK1(6), JAK3(11), LCK(15), NMI(4), PIK3CA(10), PIK3R1(2), PTK2B(10), STAT5A(3), STAT5B(6)	11432242	159	92	156	77	93	18	8	23	15	2	0.410	1.000	1.000
319	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(5), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(77), UGT2B15(31), UGT2B4(34)	7256911	157	92	140	71	114	13	6	6	17	1	0.0206	1.000	1.000
320	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(4), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CFLAR(4), DAXX(9), DFFA(2), DFFB(2), FAF1(8), JUN(1), LMNA(7), LMNB1(1), LMNB2(4), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(7), PRKDC(19), PTPN13(15), RB1(10), RIPK2(3), SPTAN1(10)	16729834	141	91	140	75	68	12	12	25	22	2	0.857	1.000	1.000
321	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(2), ARSD(3), ARSE(5), GAL3ST1(10), GALC(3), GBA(7), GLA(2), GLB1(9), LCT(51), NEU1(6), NEU2(17), NEU3(4), NEU4(16), PPAP2A(1), PPAP2B(11), PPAP2C(8), SMPD1(2), SMPD2(2), SPTLC1(1), SPTLC2(6), UGCG(1)	9818145	167	91	162	92	114	13	3	19	18	0	0.456	1.000	1.000
322	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(4), EIF4A1(4), EIF4A2(4), EIF4B(5), EIF4EBP1(1), EIF4G1(18), EIF4G2(4), EIF4G3(17), MKNK1(6), PDK2(4), PDPK1(3), PIK3CA(10), PIK3R1(2), PTEN(23), RPS6(1), RPS6KB1(3), TSC1(9), TSC2(12)	11324492	130	91	125	43	62	11	9	16	30	2	0.0648	1.000	1.000
323	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(10), CCR2(17), CCR3(10), CCR4(9), CCR5(10), CCR7(4), CD28(2), CD4(8), CSF2(2), CXCR3(4), CXCR4(3), IFNG(4), IFNGR1(3), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18R1(21), IL2(4), IL4(1), IL4R(16), IL5(4), TGFB1(2), TGFB2(3), TGFB3(3)	8175886	169	91	158	90	120	13	2	15	19	0	0.0273	1.000	1.000
324	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(6), ESR2(9), PDE1A(43), PDE1B(16), PLCB1(54), PLCB2(12), PRL(3), TRH(4), VIP(5)	4509506	152	91	134	59	116	4	2	14	16	0	0.00130	1.000	1.000
325	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(19), FOS(2), HRAS(3), JUN(1), MAP2K1(14), MAPK1(4), MAPK3(4), MYC(5), NFKB1(6), NFKBIA(2), PLCB1(54), PRKCA(8), RAF1(10), RELA(4), TNF(1)	6384130	137	90	121	56	90	9	7	17	14	0	0.0216	1.000	1.000
326	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), BBOX1(6), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(10), EHMT2(11), GCDH(6), HADHA(6), PLOD1(5), PLOD2(6), PLOD3(4), SDS(2), SHMT1(2), SHMT2(3), TMLHE(2)	15089616	150	90	144	80	91	15	7	20	17	0	0.359	1.000	1.000
327	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(4), MAPK8(1), MAPK8IP1(7), MAPK8IP2(7), MAPK8IP3(10), MAPK9(3), MAPKAPK5(1), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), PIK3CA(10), PIK3CD(8), PIK3R1(2), SYT1(23), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4)	13702244	145	90	140	93	95	10	7	20	12	1	0.780	1.000	1.000
328	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(6), AZIN1(2), BTG1(3), CBX3(1), CLOCK(3), CRY1(6), CRY2(6), EIF4G2(4), ETV6(10), GFRA1(8), GSTM3(4), GSTP1(3), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(3), MYF6(14), NCKAP1(5), NCOA4(4), NR1D2(10), PER1(8), PER2(11), PIGF(2), PPP1R3C(4), PPP2CB(2), PSMA4(2), PURA(2), SF3A3(6), TOB1(3), TUBB3(4), UCP3(6), UGP2(1), VAPA(2), ZFR(9)	14946204	162	89	160	73	84	13	15	29	21	0	0.548	1.000	1.000
329	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(6), BCL2(2), BIRC2(6), BIRC3(7), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CYCS(1), DFFA(2), DFFB(2), GAS2(13), LMNA(7), MAP3K14(6), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), SPTAN1(10), TNFRSF10A(7), TNFRSF10B(4), TNFRSF25(6), TNFSF10(8), TRAF2(2)	13679051	133	89	131	77	75	16	9	20	13	0	0.788	1.000	1.000
330	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLA2(8), POLB(1), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLG(9), POLG2(7), POLH(5), POLI(2), POLK(7), POLL(8), POLM(2), POLQ(25), PRIM1(2), PRIM2(21), REV1(3), REV3L(18)	16568366	155	89	151	65	86	11	11	28	19	0	0.316	1.000	1.000
331	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(13), ARHGEF1(1), GNA12(3), GNA13(1), GNAQ(6), GNB1(1), MYL2(9), MYLK(46), PLCB1(54), PPP1R12B(7), PRKCA(8), ROCK1(7)	8509950	156	89	139	68	111	3	7	18	17	0	0.115	1.000	1.000
332	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(39), AKT1(4), ATM(15), BAX(3), CDKN1A(3), CPB2(1), CSNK1A1(3), CSNK1D(3), HIC1(1), HIF1A(4), IGFBP3(2), MAPK8(1), MDM2(1), NFKBIB(1), NQO1(2), TP53(51)	8515636	134	89	115	40	72	8	7	14	32	1	0.00832	1.000	1.000
333	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(4), AKT2(8), AKT3(3), BCL2(2), GRB2(2), GSK3A(1), GSK3B(3), IL4R(16), IRS1(5), IRS2(3), JAK1(6), JAK3(11), MAP4K1(11), MAPK1(4), MAPK3(4), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(2), PPP1R13B(9), RAF1(10), SHC1(2), SOCS1(1), SOS1(10), SOS2(13), STAT6(8)	14967558	158	89	157	63	88	19	6	26	18	1	0.0781	1.000	1.000
334	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(5), ABAT(9), ADSL(5), ADSS(1), AGXT(10), AGXT2(24), ASL(6), ASNS(8), ASPA(3), CAD(18), CRAT(5), DARS(4), DDO(8), GAD1(13), GAD2(9), GOT1(6), GOT2(6), GPT(3), GPT2(2), NARS(2), PC(14)	10712903	161	88	153	87	111	15	8	13	14	0	0.148	1.000	1.000
335	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(10), CSF1R(13), EGF(21), EGFR(25), GRB2(2), MET(23), PDGFRA(34), PRKCA(8), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(2)	7987039	147	88	145	87	94	11	5	18	19	0	0.819	1.000	1.000
336	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(4), APAF1(6), ATM(15), BAX(3), BCL2(2), CASP3(2), CASP7(4), CASP9(2), CYCS(1), EIF2S1(1), PRKCA(8), PTK2(7), PXN(2), STAT1(5), TLN1(12), TP53(51)	11179702	125	88	112	37	61	11	7	14	31	1	0.00454	1.000	1.000
337	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(24), G6PD(3), GCLC(5), GCLM(2), GGT1(8), GPX1(3), GPX3(4), GPX5(17), GPX6(16), GSR(2), GSS(8), GSTA1(6), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(3), GSTM1(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH1(16), IDH2(1), MGST1(2), MGST2(2), MGST3(1), OPLAH(12), TXNDC12(1)	8966227	164	88	147	83	113	10	7	21	13	0	0.0268	1.000	1.000
338	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(6), CDK5R1(1), DAB1(45), FYN(7), LRP8(3), RELN(88), VLDLR(5)	5731127	155	88	149	84	112	9	3	12	18	1	0.833	1.000	1.000
339	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(5), GLB1(9), GNS(1), GUSB(5), HEXA(6), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(51), NAGLU(4), SPAM1(27)	8333211	150	87	147	81	110	8	3	13	16	0	0.353	1.000	1.000
340	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(43), ITGAL(28), ITGB1(4), ITGB2(16), SELE(33), SELL(10)	4919605	141	87	136	47	102	4	5	11	19	0	0.00434	1.000	1.000
341	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(34), CAP1(2), CDC25C(5), GNAI1(2), GNAS(25), GNB1(1), HRAS(3), MAPK1(4), MAPK3(4), MYT1(21), PIN1(1), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RPS6KA1(8), SRC(2)	8412913	144	87	139	93	93	15	8	14	14	0	0.761	1.000	1.000
342	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(21), EPHB1(29), FYN(7), ITGA1(24), ITGB1(4), L1CAM(11), LYN(10), RAP1B(1), SELP(39)	6468566	150	86	138	70	107	6	3	17	17	0	0.145	1.000	1.000
343	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(9), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(26), EPRS(13), GAD1(13), GAD2(9), GCLC(5), GCLM(2), GFPT1(4), GLS(2), GLS2(3), GLUD1(2), GLUL(2), GMPS(6), GOT1(6), GOT2(6), GPT(3), GPT2(2), GSS(8), NADSYN1(4), QARS(6)	13613547	165	86	158	82	97	18	9	24	17	0	0.292	1.000	1.000
344	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH1C(1), ADH4(10), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), PNPLA3(3), SH3GLB1(2)	10266613	135	86	118	53	98	9	7	14	7	0	0.0576	1.000	1.000
345	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), IL2(4), IL2RA(5), IL2RB(12), IL2RG(3), JAK1(6), JAK3(11), JUN(1), LCK(15), MAP2K1(14), MAPK3(4), MAPK8(1), RAF1(10), SHC1(2), SOS1(10), STAT5A(3), STAT5B(6), SYK(14)	9436903	135	86	127	63	78	12	6	25	14	0	0.237	1.000	1.000
346	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(7), GALNT2(6), GALNT3(4), GALNT4(5), GALNT6(17), GALNT7(4), GALNT8(27), GALNT9(7), GCNT1(6), ST3GAL1(7), ST3GAL2(1), ST3GAL4(2), WBSCR17(44)	5941983	141	86	130	63	101	8	3	14	15	0	0.0748	1.000	1.000
347	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(34), ADRB2(3), GNAS(25), PLCE1(57), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	6000047	147	86	140	76	92	17	9	15	14	0	0.377	1.000	1.000
348	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(1), CHUK(2), EGR2(5), EGR3(4), GNAQ(6), MAP3K1(4), MYC(5), NFATC1(16), NFATC2(11), NFKB1(6), NFKBIA(2), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), SYT1(23), VIP(5), VIPR2(7)	11431323	148	86	142	89	93	12	9	15	19	0	0.840	1.000	1.000
349	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(34), ADRB2(3), CFTR(60), GNAS(25), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(2)	5320112	152	85	140	90	99	14	6	14	18	1	0.619	1.000	1.000
350	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(39), ABCB11(49), ABCB4(21), ABCC1(15), ABCC3(29), GSTP1(3)	5833505	156	85	144	73	104	16	5	12	19	0	0.00159	1.000	1.000
351	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(24), DUSP1(1), EP300(18), IKBKB(4), IL1B(8), IL8(1), MAP2K3(8), MAP2K6(3), MAP3K14(6), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(3), NFKB1(6), NFKBIA(2), NR3C1(7), RELA(4), TGFBR2(9), TLR2(15), TNF(1)	12170632	129	85	128	72	77	19	6	17	10	0	0.817	1.000	1.000
352	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), CDK7(2), ERCC3(6), GTF2A2(1), GTF2B(4), GTF2E1(3), GTF2E2(5), GTF2F2(2), GTF2H1(3), GTF2H4(2), ILK(2), MNAT1(2), POLR1A(13), POLR1B(9), POLR2A(13), POLR2B(12), POLR2C(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3B(14), POLR3D(1), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(2), TAF6(4), TAF7(2), TBP(4)	14404128	122	85	119	54	74	9	9	18	12	0	0.253	1.000	1.000
353	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(4), FUCA1(3), GLB1(9), HEXA(6), HEXB(4), LCT(51), MAN2B1(8), MAN2B2(10), MAN2C1(7), MANBA(8), NEU1(6), NEU2(17), NEU3(4), NEU4(16)	8315673	153	84	150	68	112	13	2	14	12	0	0.0337	1.000	1.000
354	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(8), ACTN2(20), ACTN3(3), CAPN1(4), CAPNS1(3), CAPNS2(1), ITGA1(24), ITGB1(4), ITGB3(15), PTK2(7), PXN(2), RAC1(20), SPTAN1(10), SRC(2), TLN1(12)	11541317	139	84	126	67	93	9	5	16	15	1	0.0229	1.000	1.000
355	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(2), CDT1(3), DIAPH2(6), MCM10(7), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), PCNA(2), POLA2(8), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), PRIM1(2), RFC1(5), RFC2(3), RFC3(1), RPA1(3), RPA2(1), RPA4(2), UBC(13)	20724793	133	83	131	90	83	9	8	17	16	0	0.959	1.000	1.000
356	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(12), CSF1R(13), DDX20(11), E2F1(5), E2F4(3), ETS1(4), ETS2(8), ETV3(3), FOS(2), HDAC2(2), HDAC5(6), HRAS(3), JUN(1), NCOR2(26), RBL1(12), RBL2(6), SIN3A(11), SIN3B(8)	10633541	136	83	136	69	88	7	3	26	12	0	0.324	1.000	1.000
357	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(24), G6PD(3), GCLC(5), GCLM(2), GGT1(8), GPX1(3), GPX3(4), GPX5(17), GSS(8), GSTA1(6), GSTA2(3), GSTA3(1), GSTA4(1), GSTM1(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH1(16), IDH2(1), MGST1(2), MGST2(2), MGST3(1), PGD(9)	7397584	136	83	120	59	92	8	7	18	11	0	0.00547	1.000	1.000
358	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), ALDOB(14), ALDOC(4), DERA(2), FBP1(3), FBP2(2), G6PD(3), GPI(3), H6PD(7), PFKL(4), PFKM(2), PFKP(2), PGD(9), PGLS(2), PGM1(6), PGM3(1), PRPS1(2), PRPS1L1(13), PRPS2(2), RBKS(4), TALDO1(3), TKT(6), TKTL1(3), TKTL2(26)	9931782	125	83	118	82	84	11	7	8	15	0	0.424	1.000	1.000
359	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(9), GBA3(19), LPO(20), MPO(11), PRDX1(3), PRDX2(3), PRDX6(4), TPO(47), TYR(9)	3958513	125	83	118	65	92	13	1	6	13	0	0.0957	1.000	1.000
360	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(25), AXIN1(9), BTRC(4), CCND1(2), CREBBP(24), CSNK1A1(3), CSNK1D(3), CSNK2A1(4), CTNNB1(14), FZD1(5), GSK3B(3), HDAC1(2), MAP3K7(1), MYC(5), NLK(5), PPARD(3), TLE1(4), WIF1(7), WNT1(2)	11957492	125	83	123	63	60	11	10	21	23	0	0.807	1.000	1.000
361	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(4), BCL2(2), BCR(15), CRKL(3), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAP2K1(14), MAP2K4(4), MAP3K1(4), MAPK3(4), MAPK8(1), MYC(5), PIK3CA(10), PIK3R1(2), RAF1(10), SOS1(10), STAT1(5), STAT5A(3), STAT5B(6)	11463193	118	82	110	50	59	13	8	23	14	1	0.339	1.000	1.000
362	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(10), CHIT1(12), CMAS(2), CTBS(5), CYB5R1(2), CYB5R3(2), GFPT1(4), GFPT2(8), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(6), HEXB(4), HK1(3), HK2(13), HK3(14), LHPP(1), MTMR1(5), MTMR2(2), MTMR6(2), NAGK(1), NANS(1), NPL(1), PGM3(1), RENBP(4), UAP1(2)	11741982	114	82	112	67	71	10	6	16	11	0	0.713	1.000	1.000
363	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(2), AGPAT3(6), AGPAT4(6), AGPAT6(3), AGPS(4), CHPT1(1), ENPP2(2), ENPP6(13), PAFAH1B1(4), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12), PLD1(13), PLD2(8), PPAP2A(1), PPAP2B(11), PPAP2C(8)	9549493	157	82	151	75	99	11	5	16	25	1	0.135	1.000	1.000
364	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(15), ABCC2(11), ABCG2(6), BCHE(8), CES1(21), CES2(4), CYP3A4(20), UGT1A1(77)	9392151	162	82	151	67	114	13	5	13	17	0	0.00111	1.000	1.000
365	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), ESRRA(3), HDAC5(6), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), PPARA(7), PPP3CA(5), PPP3CB(3), PPP3CC(2), SLC2A4(9), SYT1(23)	8217895	131	82	124	73	95	8	5	11	12	0	0.311	1.000	1.000
366	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(4), CASP9(2), CDC42(2), CHUK(2), ELK1(3), H2AFX(2), HRAS(3), MAP2K1(14), MAPK3(4), NFKB1(6), PIK3CA(10), PIK3R1(2), RAC1(20), RAF1(10), RALA(1), RALBP1(3), RALGDS(12), RELA(4), RHOA(2)	7743045	106	82	87	46	62	13	2	22	6	1	0.248	1.000	1.000
367	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(12), AGT(8), AGTR2(9), EDN1(9), EDNRA(10), EDNRB(7), EGF(21), EGFR(25), FOS(2), HRAS(3), JUN(1), MYC(5), NFKB1(6), PLCG1(8), PRKCA(8), RELA(4)	8415441	138	81	135	73	92	11	8	12	15	0	0.297	1.000	1.000
368	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(6), CDK5R1(1), CSNK1D(3), DRD1(9), DRD2(14), GRM1(16), PLCB1(54), PPP1CA(1), PPP1R1B(2), PPP3CA(5), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	6534766	139	81	131	90	102	3	5	14	15	0	0.677	1.000	1.000
369	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(4), CCND1(2), CCNE1(4), CDK4(7), CDK6(2), CDKN1A(3), CDKN1B(1), E2F1(5), HRAS(3), MAPK1(4), MAPK3(4), NFKB1(6), NFKBIA(2), PAK1(4), PIK3CA(10), PIK3R1(2), RAC1(20), RAF1(10), RB1(10), RELA(4), TFDP1(2)	8254042	109	81	94	45	54	10	7	21	14	3	0.205	1.000	1.000
370	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(4), BAG4(3), CASP2(1), CASP3(2), CASP8(9), CRADD(2), DFFA(2), DFFB(2), JUN(1), LMNA(7), LMNB1(1), LMNB2(4), MADD(19), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(7), PRKDC(19), RB1(10), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TRAF2(2)	15912617	127	81	125	64	64	10	12	18	21	2	0.520	1.000	1.000
371	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(15), ABP1(22), AOC2(9), AOC3(10), CES1(21), DDHD1(7), ESCO1(2), ESCO2(4), LIPA(5), PLA1A(10), PNPLA3(3), PPME1(1), PRDX6(4), SH3GLB1(2)	10394627	115	80	111	62	86	4	9	7	9	0	0.645	1.000	1.000
372	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(25), CDH1(5), CREBBP(24), EP300(18), MAP2K1(14), MAP3K7(1), MAPK3(4), SKIL(3), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9)	10553679	111	80	104	48	59	12	7	19	14	0	0.612	1.000	1.000
373	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(21), EGFR(25), MAP2K1(14), MAP3K1(4), MAPK14(5), NCOR2(26), RARA(4), RXRA(4), THRA(2), THRB(18)	7030613	123	79	115	59	81	11	3	14	14	0	0.259	1.000	1.000
374	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(4), EIF2B5(2), EIF2S1(1), EIF2S3(1), EIF4EBP1(1), GSK3B(3), IGF1(10), IGF1R(14), INPPL1(16), PDK2(4), PDPK1(3), PIK3CA(10), PIK3R1(2), PTEN(23), RPS6(1), RPS6KB1(3)	8035140	98	79	91	40	48	11	8	11	19	1	0.336	1.000	1.000
375	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(2), GLI2(42), GLI3(18), GSK3B(3), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SHH(3), SMO(10), SUFU(2)	6805969	112	79	109	67	75	11	6	9	11	0	0.601	1.000	1.000
376	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(10), AKR1D1(19), CYP11A1(14), CYP11B1(18), CYP11B2(14), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(3), HSD3B1(14), HSD3B2(14)	3967804	140	78	129	68	98	14	5	9	14	0	0.00184	1.000	1.000
377	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(34), GNAS(25), GNB1(1), PRKAA1(1), PRKAA2(30), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(11), PRKAG1(3), PRKAG2(8), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	6266929	134	78	128	65	87	14	7	9	17	0	0.300	1.000	1.000
378	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(9), GABRA1(18), GABRA2(18), GABRA3(22), GABRA4(15), GABRA5(4), GABRA6(28), GPHN(8), SRC(2), UBQLN1(5)	4815739	129	78	113	69	96	6	4	11	10	2	0.349	1.000	1.000
379	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(10), AKR1D1(19), CYP11A1(14), CYP11B1(18), CYP11B2(14), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(3), HSD3B1(14), HSD3B2(14)	3967804	140	78	129	68	98	14	5	9	14	0	0.00184	1.000	1.000
380	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(9), GBA(7), GBA3(19), LPO(20), MPO(11), PRDX6(4), TPO(47)	3436642	117	78	110	65	87	12	1	7	10	0	0.127	1.000	1.000
381	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(10), CD3D(7), CD3E(2), CD3G(1), CXCR3(4), ETV5(7), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), JAK2(8), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(1), STAT4(26), TYK2(8)	7601855	136	78	131	62	94	8	4	14	16	0	0.188	1.000	1.000
382	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), INSR(26), IRS1(5), JUN(1), MAP2K1(14), MAPK3(4), MAPK8(1), PIK3CA(10), PIK3R1(2), PTPN11(10), RAF1(10), RASA1(4), SHC1(2), SLC2A4(9), SOS1(10), SRF(3)	10492741	125	78	113	57	55	16	6	36	11	1	0.665	1.000	1.000
383	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(4), AKT2(8), AKT3(3), GRB2(2), ILK(2), MAPK1(4), MAPK3(4), PDK1(2), PIK3CA(10), PIK3CD(8), PTEN(23), PTK2B(10), RBL2(6), SHC1(2), SOS1(10)	8399648	98	78	95	41	41	8	6	23	20	0	0.539	1.000	1.000
384	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(4), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAP2K1(14), MAPK3(4), MPL(8), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), RAF1(10), RASA1(4), SHC1(2), SOS1(10), STAT1(5), STAT3(9), STAT5A(3), STAT5B(6), THPO(9)	12250033	132	78	123	62	70	13	8	29	11	1	0.654	1.000	1.000
385	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(8), ASRGL1(6), CA1(9), CA12(3), CA13(5), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(4), CA7(2), CA8(6), CA9(8), CPS1(26), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), HAL(14)	8642032	131	77	126	64	92	9	4	14	12	0	0.272	1.000	1.000
386	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(2), MRPS7(1), RPL10A(1), RPL10L(8), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL18(5), RPL18A(2), RPL19(1), RPL21(1), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL38(1), RPL39(1), RPL3L(5), RPL6(1), RPL7(1), RPS11(1), RPS13(1), RPS16(2), RPS18(2), RPS2(2), RPS20(2), RPS24(1), RPS26(1), RPS27(25), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS7(4), RPS8(1), RPSA(10)	9225890	107	77	84	49	45	6	7	13	36	0	0.0764	1.000	1.000
387	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), IGF1(10), IGF1R(14), IRS1(5), JUN(1), MAP2K1(14), MAPK3(4), MAPK8(1), PIK3CA(10), PIK3R1(2), PTPN11(10), RAF1(10), RASA1(4), SHC1(2), SOS1(10), SRF(3)	10156612	114	77	101	51	55	18	3	28	9	1	0.600	1.000	1.000
388	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(2), DLAT(4), DLD(3), FH(3), IDH2(1), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(3), OGDH(8), PC(14), PDHA1(4), PDHA2(20), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(5), PDK4(7), PDP2(6), SDHA(3), SDHC(3), SDHD(1), SUCLG1(3), SUCLG2(2)	11658051	116	77	113	56	74	6	7	12	17	0	0.272	1.000	1.000
389	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), IKBKB(4), IL1A(5), IL1R1(13), IRAK1(5), MAP3K1(4), MAP3K14(6), MAP3K7(1), MYD88(3), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TLR4(41), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4)	9836402	114	77	108	63	80	8	5	10	11	0	0.555	1.000	1.000
390	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(37), AGT(8), AGTR1(10), AGTR2(9), BDKRB2(9), KNG1(14), NOS3(19), REN(11)	4058169	117	76	111	71	76	8	7	8	18	0	0.157	1.000	1.000
391	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(1), CDKN1A(3), GNAQ(6), MARCKS(1), NFATC1(16), NFATC2(11), NFATC3(10), NFATC4(17), PLCG1(8), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKCA(8), SP1(5), SP3(1), SYT1(23)	8583114	121	76	114	52	77	13	8	8	15	0	0.171	1.000	1.000
392	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(6), ALOX15(10), ALOX15B(8), ALOX5(12), ALOX5AP(1), DPEP1(4), GGT1(8), LTA4H(5), PLA2G2A(2), PLA2G6(12), PTGDS(3), PTGES(1), PTGIS(17), PTGS1(20), PTGS2(13), TBXAS1(16)	6113759	138	76	134	74	90	12	4	14	18	0	0.0338	1.000	1.000
393	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(3), AKT1(4), ANXA1(7), CALM1(1), CALM2(1), GNAS(25), GNB1(1), NFKB1(6), NOS3(19), NPPA(4), NR3C1(7), PIK3CA(10), PIK3R1(2), RELA(4), SYT1(23)	7299775	117	76	109	61	78	11	5	18	4	1	0.674	1.000	1.000
394	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(13), BCAT2(1), IARS(8), IARS2(16), ILVBL(5), LARS(12), LARS2(5), PDHA1(4), PDHA2(20), PDHB(1), VARS(18), VARS2(7)	7728355	110	76	102	47	70	12	3	13	12	0	0.196	1.000	1.000
395	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(24), FOS(2), GRB2(2), HRAS(3), IL3(3), IL3RA(7), JAK2(8), MAP2K1(14), MAPK3(4), PTPN6(5), RAF1(10), SHC1(2), SOS1(10), STAT5A(3), STAT5B(6)	7201635	103	76	95	45	58	5	6	17	17	0	0.230	1.000	1.000
396	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), CAT(8), EPX(9), LPO(20), MPO(11), PRDX1(3), PRDX2(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(47)	4846357	113	76	109	62	84	10	1	8	10	0	0.102	1.000	1.000
397	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(4), FUCA1(3), GLB1(9), HEXA(6), HEXB(4), LCT(51), MAN2C1(7), MANBA(8), NEU1(6), NEU2(17), NEU3(4), NEU4(16)	6748124	135	76	132	59	100	10	1	13	11	0	0.0692	1.000	1.000
398	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(3), CNR1(13), CNR2(5), DNMT1(20), MTNR1A(10), MTNR1B(8), PTAFR(2), PTGDR(11), PTGER2(7), PTGER4(2), PTGFR(21), PTGIR(5), TBXA2R(4)	4569549	111	76	106	85	76	14	4	9	8	0	0.398	1.000	1.000
399	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(2), ATG5(2), ATG7(11), BECN1(3), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(2), IFNA7(6), IFNA8(3), IFNG(4), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(30), ULK1(9), ULK2(7), ULK3(1)	8553936	128	75	122	66	89	8	6	13	12	0	0.314	1.000	1.000
400	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), IL6(2), IL6R(3), IL6ST(10), JAK1(6), JAK2(8), JAK3(11), JUN(1), MAP2K1(14), MAPK3(4), PTPN11(10), RAF1(10), SHC1(2), SOS1(10), SRF(3), STAT3(9)	9749410	117	75	108	57	54	16	5	31	11	0	0.726	1.000	1.000
401	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(16), CALM1(1), CALM2(1), CAPN2(5), CAPNS1(3), CAPNS2(1), EP300(18), HDAC1(2), HDAC2(2), MEF2D(6), NFATC1(16), NFATC2(11), PPP3CA(5), PPP3CB(3), PPP3CC(2), PRKCA(8), SYT1(23)	10056233	123	75	117	51	78	7	10	12	16	0	0.117	1.000	1.000
402	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(4), AP2A1(2), AP2M1(2), BTK(16), EEA1(3), GRASP(2), GSK3A(1), GSK3B(3), LYN(10), PDPK1(3), PFKL(4), PFKM(2), PFKP(2), PLCG1(8), PRKCE(6), PRKCZ(7), RAB5A(2), RAC1(20), RPS6KB1(3), VAV2(3)	10128791	103	75	91	56	64	9	6	8	16	0	0.215	1.000	1.000
403	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(4), PIK3CA(10), PIK3R1(2), PLCB1(54), PLCG1(8), PRKCA(8), VAV1(19)	5274155	105	74	97	55	79	4	2	8	11	1	0.430	1.000	1.000
404	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(27), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD8A(2), ICAM1(2), ITGAL(28), ITGB2(16), PTPRC(35), THY1(1)	4364639	123	74	114	49	83	7	4	8	21	0	0.00382	1.000	1.000
405	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(27), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(8), ICAM1(2), ITGAL(28), ITGB2(16), PTPRC(35), THY1(1)	4575359	129	74	119	53	86	8	4	9	22	0	0.00447	1.000	1.000
406	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(2), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GCK(17), GMDS(5), GMPPA(1), GMPPB(4), HK1(3), HK2(13), HK3(14), KHK(1), MPI(1), PFKFB1(4), PFKFB3(2), PFKFB4(6), PFKM(2), PFKP(2), PMM1(3), PMM2(2), SORD(2), TPI1(1)	9752657	110	73	105	78	75	14	5	4	12	0	0.499	1.000	1.000
407	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(8), CYP2A13(12), CYP2A6(9), CYP2A7(10), NAT1(2), NAT2(10), XDH(59)	3294981	110	73	102	70	86	6	6	2	10	0	0.0893	1.000	1.000
408	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(20), DNMT3A(8), DNMT3B(13), MARS(7), MARS2(4), MAT1A(6), MAT2B(1), MTAP(4), MTFMT(2), MTR(11), SRM(1), TAT(19)	8583741	117	73	115	46	75	8	8	11	15	0	0.0169	1.000	1.000
409	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(22), PGAP1(8), PIGA(1), PIGB(3), PIGC(2), PIGF(2), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(1), PIGN(3), PIGO(12), PIGQ(9), PIGS(1), PIGT(1), PIGU(7), PIGV(8), PIGW(1), PIGX(2), PIGZ(3)	9777985	109	73	108	49	61	8	7	23	10	0	0.122	1.000	1.000
410	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(75), CYP2C9(38)	829278	113	73	100	73	87	6	2	2	16	0	0.644	1.000	1.000
411	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(37), CD44(5), CSF1(12), FCGR3A(7), IL1B(8), IL6R(3), SELL(10), SPN(5), TGFB1(2), TGFB2(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFRSF8(19), TNFSF8(3)	5309119	123	73	117	58	89	7	7	3	17	0	0.0441	1.000	1.000
412	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(8), ACTN2(20), ACTN3(3), BCAR1(5), CSK(1), CTNNA1(3), CTNNA2(30), CTNNB1(14), PTK2(7), PXN(2), SRC(2), VCL(8)	7735613	103	72	98	55	60	8	7	12	15	1	0.233	1.000	1.000
413	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(6), ACO2(5), CS(2), DLD(3), FH(3), IDH1(16), IDH2(1), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(3), PC(14), PCK1(25), SDHA(3), SUCLG1(3), SUCLG2(2)	8498275	96	72	84	56	68	1	5	11	11	0	0.554	1.000	1.000
414	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(8), EPX(9), LPO(20), MPO(11), MTHFR(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(47)	4785463	110	72	106	64	84	9	1	8	8	0	0.174	1.000	1.000
415	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(6), GTF2A1(2), GTF2B(4), GTF2E1(3), GTF2F1(5), HDAC3(5), NCOA1(9), NCOA2(13), NCOA3(18), NCOR2(26), POLR2A(13), RARA(4), RXRA(4), TBP(4)	10174152	116	72	114	47	89	4	5	10	8	0	0.0741	1.000	1.000
416	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(4), AKT2(8), AKT3(3), CDKN1A(3), ELK1(3), GRB2(2), HRAS(3), MAP2K1(14), MAP2K2(5), NGFR(8), NTRK1(16), PIK3CA(10), PIK3CD(8), SHC1(2), SOS1(10)	6550594	99	72	90	38	48	16	4	19	12	0	0.112	1.000	1.000
417	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(15), APOA1(2), APOA4(9), APOC1(3), APOC3(2), APOE(1), CETP(6), CYP7A1(8), DGAT1(1), HMGCR(12), LDLR(17), LIPC(10), LPL(6), LRP1(40), SCARB1(5), SOAT1(3)	11326568	140	72	133	70	73	20	8	18	20	1	0.124	1.000	1.000
418	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(5), CARS(8), DARS(4), EPRS(13), FARS2(6), GARS(6), HARS(6), IARS(8), KARS(3), LARS(12), LARS2(5), MARS(7), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(5), TARS(5), WARS(5), WARS2(4), YARS(3)	13203117	124	71	119	52	75	11	6	13	18	1	0.119	1.000	1.000
419	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(3), GPT2(2), MDH1(3), MDH2(3), ME1(20), ME2(2), ME3(8), PGK1(2), PKLR(13), PKM2(7), TKT(6), TPI1(1)	7417666	107	71	104	59	78	9	3	6	10	1	0.129	1.000	1.000
420	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(4), MAP2K1(14), MAP2K2(5), MAP2K3(8), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(4), NFKB1(6), PIK3CA(10), PIK3R1(2), RB1(10), RELA(4), SP1(5)	7924331	88	71	79	40	39	12	4	15	15	3	0.578	1.000	1.000
421	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CARM1(4), CBS(7), CTH(1), GGT1(8), HEMK1(4), LCMT1(4), LCMT2(1), MARS(7), MARS2(4), MAT1A(6), MAT2B(1), METTL2B(7), METTL6(1), PAPSS1(4), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), SCLY(4), SEPHS1(2), SEPHS2(2), WBSCR22(1)	10266080	106	71	105	50	65	13	6	10	12	0	0.118	1.000	1.000
422	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(8), CA1(9), CA12(3), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(4), CA7(2), CA8(6), CA9(8), CPS1(26), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(2), HAL(14)	7730281	116	71	112	59	82	6	3	14	11	0	0.378	1.000	1.000
423	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), G6PD(3), GPI(3), H6PD(7), PFKM(2), PFKP(2), PGD(9), PGLS(2), PGM1(6), PGM3(1), PRPS1(2), PRPS1L1(13), PRPS2(2), RBKS(4), TAL1(9), TALDO1(3), TKT(6)	8368396	99	71	95	66	66	7	6	8	12	0	0.524	1.000	1.000
424	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(54), NRG2(7), NRG3(24), PRKCA(8), PSEN1(1)	3658827	95	70	85	35	70	4	3	4	14	0	0.0323	1.000	1.000
425	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(18), GABRA2(18), GABRA3(22), GABRA4(15), GABRA5(4), GABRA6(28), GPX1(3), PRKCE(6)	3174247	114	70	99	54	83	8	3	10	8	2	0.116	1.000	1.000
426	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(5), GLB1(9), HEXA(6), HEXB(4), LCT(51), SLC33A1(6), ST3GAL1(7), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(6), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(10)	6757190	125	70	123	71	87	10	1	17	10	0	0.386	1.000	1.000
427	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(26), BST1(2), CD38(6), ENPP1(13), ENPP3(13), NADK(4), NADSYN1(4), NMNAT1(1), NMNAT2(5), NMNAT3(11), NNMT(10), NNT(3), NT5C1A(6), NT5C2(3), NT5C3(2), NT5E(6), NT5M(2), NUDT12(5), QPRT(6)	8826972	128	70	121	61	77	11	5	16	19	0	0.302	1.000	1.000
428	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(20), CPT1A(14), LEP(4), LEPR(29), PRKAA1(1), PRKAA2(30), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8)	5980374	113	70	105	53	78	5	3	9	18	0	0.405	1.000	1.000
429	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(19), AP2A1(2), AP2M1(2), BIN1(5), CALM1(1), CALM2(1), DNM1(9), EPN1(6), EPS15(3), PICALM(2), PPP3CA(5), PPP3CB(3), PPP3CC(2), SYNJ1(20), SYNJ2(22), SYT1(23)	8763788	125	70	119	60	85	9	4	14	13	0	0.296	1.000	1.000
430	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(28), ITGAM(23), ITGB2(16), SELE(33), SELL(10)	4209399	117	70	117	46	85	4	4	6	18	0	0.00523	1.000	1.000
431	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(10), CD2(27), CD3D(7), CD3E(2), CD3G(1), CD4(8), CXCR3(4), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), JAK2(8), STAT4(26), TYK2(8)	5963286	130	70	121	58	86	11	4	11	18	0	0.0588	1.000	1.000
432	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(5), B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), FUT1(3), FUT2(3), FUT3(8), FUT4(4), FUT5(8), FUT6(4), FUT7(2), FUT9(30), ST3GAL6(2), ST8SIA1(1)	6552519	97	69	92	46	59	11	6	10	11	0	0.0857	1.000	1.000
433	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(9), PARK2(10), SNCA(2), SNCAIP(62), UBE2E2(4), UBE2F(4), UBE2G2(1), UBE2L3(1), UBE2L6(1)	2642493	94	69	85	33	72	9	3	5	5	0	0.0182	1.000	1.000
434	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(2), CD3D(7), CD3E(2), CD3G(1), CD80(4), CD86(25), CTLA4(2), GRB2(2), HLA-DRA(12), ICOS(2), IL2(4), ITK(24), LCK(15), PIK3CA(10), PIK3R1(2), PTPN11(10)	5243543	124	68	115	44	82	8	2	15	16	1	0.0638	1.000	1.000
435	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(4), BCAR1(5), CDKN1B(1), GRB2(2), ILK(2), ITGB1(4), MAPK1(4), MAPK3(4), PDK2(4), PDPK1(3), PIK3CA(10), PIK3R1(2), PTEN(23), PTK2(7), SHC1(2), SOS1(10)	7846750	87	68	83	35	37	7	6	18	18	1	0.602	1.000	1.000
436	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), CD86(25), HLA-DRA(12), IFNG(4), IFNGR1(3), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), IL2(4), IL2RA(5), IL4(1), IL4R(16)	5178800	125	68	117	47	92	6	0	8	19	0	0.0103	1.000	1.000
437	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), NCK1(2), NCKAP1(5), NTRK1(16), PIR(1), RAC1(20), WASF1(4), WASF2(5), WASF3(13), WASL(5)	6272862	85	67	73	35	59	5	3	10	8	0	0.314	1.000	1.000
438	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), ELK1(3), EPO(5), EPOR(1), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAP2K1(14), MAPK3(4), MAPK8(1), PLCG1(8), PTPN6(5), RAF1(10), SHC1(2), SOS1(10), STAT5A(3), STAT5B(6)	8739785	92	67	85	47	44	7	7	22	12	0	0.696	1.000	1.000
439	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(4), CREBBP(24), EP300(18), NCOA3(18), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RARA(4), RXRA(4)	8494127	100	66	100	51	60	9	5	14	12	0	0.722	1.000	1.000
440	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(34), FHL5(13), FSHB(8), FSHR(19), GNAS(25), XPO1(3)	3892785	102	66	97	56	66	11	6	9	10	0	0.640	1.000	1.000
441	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(4), CAT(8), GH1(3), GHR(40), HRAS(3), IGF1(10), IGF1R(14), PIK3CA(10), PIK3R1(2), SHC1(2)	5446087	96	66	88	41	69	10	1	10	5	1	0.151	1.000	1.000
442	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(8), CARS2(3), CDO1(6), CTH(1), GOT1(6), GOT2(6), LDHA(4), LDHAL6A(4), LDHAL6B(6), LDHB(2), LDHC(5), MPST(2), SDS(2), SULT1B1(10), SULT1C2(6), SULT1C4(15), SULT4A1(10)	5152643	96	65	93	31	66	5	11	4	10	0	0.00266	1.000	1.000
443	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(3), GSR(2), GSS(8), IL8(1), NFKB1(6), NOX1(13), RELA(4), TNF(1), XDH(59)	4042042	97	64	93	47	72	8	4	7	6	0	0.0701	1.000	1.000
444	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(18), MAN1B1(3), MGAT1(3), MGAT2(2), MGAT3(11), MGAT4A(8), MGAT4B(1), MGAT5(6), RPN2(4), ST6GAL1(6)	8195159	90	64	88	57	56	10	3	11	10	0	0.689	1.000	1.000
445	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(4), DPM2(1), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), KLK2(5), MAP2K1(14), MAPK3(4), MAPK8(1), NGFR(8), PIK3CA(10), PIK3R1(2), PLCG1(8), RAF1(10), SHC1(2), SOS1(10)	7803941	90	64	82	45	44	10	3	23	9	1	0.757	1.000	1.000
446	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(4), CASP2(1), CHUK(2), CRADD(2), IKBKB(4), JUN(1), LTA(4), MAP2K3(8), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K14(6), MAP4K2(7), MAPK14(5), MAPK8(1), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TRAF2(2)	9746848	78	64	78	47	45	12	3	9	9	0	0.731	1.000	1.000
447	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(4), CHRNB1(3), CHRNG(3), MUSK(33), PIK3CA(10), PIK3R1(2), PTK2(7), PTK2B(10), RAPSN(1), SRC(2), TERT(9)	6666880	84	63	80	73	56	7	0	12	8	1	0.987	1.000	1.000
448	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(4), GRB2(2), HRAS(3), IGF1R(14), IRS1(5), MAP2K1(14), MAPK1(4), MAPK3(4), PIK3CA(10), PIK3R1(2), RAF1(10), SHC1(2), SOS1(10)	7801963	84	63	74	35	44	10	3	18	8	1	0.352	1.000	1.000
449	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(24), EP300(18), LPL(6), NCOA1(9), NCOA2(13), PPARG(14), RXRA(4)	7624908	88	63	85	33	51	11	4	13	9	0	0.250	1.000	1.000
450	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(3), BCL2(2), CASP8(9), CYCS(1), MAP2K1(14), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(4), MAPK8(1), NFKB1(6), NSMAF(6), RAF1(10), RELA(4), RIPK1(3), SMPD1(2), TNFRSF1A(4), TRAF2(2)	8355651	83	62	76	35	45	7	4	15	12	0	0.309	1.000	1.000
451	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(20), DNMT3A(8), DNMT3B(13), MARS(7), MARS2(4), MAT1A(6), MAT2B(1), MTR(11)	7223515	91	62	90	32	57	6	7	9	12	0	0.00870	1.000	1.000
452	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(11), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CAMKK1(3), CAMKK2(9), SYT1(23)	4753308	93	61	87	65	66	8	3	8	8	0	0.746	1.000	1.000
453	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(6), ARHGDIB(4), BIRC2(6), BIRC3(7), CASP1(10), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), GZMB(3), LMNA(7), LMNB1(1), LMNB2(4), PRF1(11)	8006055	90	61	89	44	52	10	6	12	10	0	0.510	1.000	1.000
454	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), CDC42(2), PAK1(4), PDGFRA(34), PIK3CA(10), PIK3R1(2), RAC1(20), WASL(5)	5513543	87	61	75	31	61	3	2	14	6	1	0.136	1.000	1.000
455	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(20), ACACB(23), FASN(23), MCAT(2), OLAH(11), OXSM(2)	6482639	81	61	79	46	49	8	3	8	13	0	0.382	1.000	1.000
456	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(13), POLR1B(9), POLR1C(1), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3A(7), POLR3B(14), POLR3G(1), POLR3GL(2), POLR3H(1), POLR3K(1)	9629506	83	61	81	42	51	8	6	11	7	0	0.464	1.000	1.000
457	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(8), CSF1(12), CSF2(2), CSF3(4), HLA-DRA(12), IFNA1(1), IFNB1(6), IFNG(4), IL10(3), IL11(3), IL12A(4), IL12B(3), IL13(2), IL15(3), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(4), IL8(1), LTA(4), PDGFA(1), TGFB1(2), TGFB2(3), TGFB3(3), TNF(1)	5391000	105	61	101	52	70	6	3	8	18	0	0.0138	1.000	1.000
458	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(7), CD3E(2), CD3G(1), CD4(8), FYN(7), HLA-DRA(12), LCK(15), PTPRC(35), ZAP70(7)	3631763	94	61	88	35	62	8	3	7	14	0	0.0169	1.000	1.000
459	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(6), CHUK(2), IFNG(4), IKBKB(4), IL2(4), IL4(1), JUN(1), MAP3K1(4), MAP3K5(23), MAP4K5(4), MAPK14(5), MAPK8(1), NFKB1(6), NFKBIA(2), RELA(4), TNFRSF9(4), TNFSF9(4), TRAF2(2)	7836951	81	60	75	40	43	6	2	13	17	0	0.568	1.000	1.000
460	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(9), ASPH(5), COPS5(4), EDN1(9), EP300(18), EPO(5), HIF1A(4), JUN(1), LDHA(4), NOS3(19), P4HB(4), VHL(4)	7010881	86	60	83	37	52	5	6	12	11	0	0.424	1.000	1.000
461	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(26), CD38(6), ENPP1(13), ENPP3(13), NADSYN1(4), NMNAT1(1), NMNAT2(5), NNMT(10), NNT(3), NT5E(6), NT5M(2), QPRT(6)	5972203	95	60	89	45	58	8	4	11	14	0	0.321	1.000	1.000
462	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(25), AXIN1(9), BTRC(4), CTNNB1(14), DLL1(2), FZD1(5), GSK3B(3), NOTCH1(9), PSEN1(1), WNT1(2)	8659751	75	60	74	49	35	9	6	11	14	0	0.968	1.000	1.000
463	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(5), GNAQ(6), GNB1(1), HTR2C(13), PLCB1(54), TUB(10)	2930462	89	60	81	43	68	2	2	8	9	0	0.130	1.000	1.000
464	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(34), MAP2(19), PPP1CA(1), PRKACB(4), PRKACG(11), PRKAG1(3), PRKAR2A(1), PRKAR2B(5), PRKCE(6)	7421684	84	59	84	43	47	8	5	10	13	1	0.780	1.000	1.000
465	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(1), LCT(51), MPI(1), PGM1(6), PYGL(9), PYGM(12), TPI1(1), TREH(4)	5409358	88	59	87	65	66	6	2	7	7	0	0.647	1.000	1.000
466	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(4), GPR161(8), GPR171(10), GPR18(4), GPR34(3), GPR39(12), GPR45(7), GPR65(14), GPR68(3), GPR75(5)	4010182	75	59	72	38	52	5	3	7	8	0	0.00779	1.000	1.000
467	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(6), BIRC2(6), BIRC3(7), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), DFFA(2), DFFB(2), GZMB(3), PRF1(11), SCAP(10), SREBF1(5), SREBF2(10)	7457504	85	59	82	47	49	8	6	12	10	0	0.637	1.000	1.000
468	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(7), ARG1(2), ARG2(2), ASL(6), CKM(3), CKMT1A(1), CKMT2(5), CPS1(26), GAMT(4), GATM(6), GLUD1(2), NAGS(1), OAT(4), ODC1(3), OTC(4), PYCR1(1), SMS(4)	7085740	83	59	80	34	49	9	4	10	11	0	0.0771	1.000	1.000
469	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(5), GLB1(9), GNS(1), GUSB(5), HEXA(6), HEXB(4), IDS(9), IDUA(4), LCT(51), NAGLU(4)	5864072	100	58	98	51	77	6	0	8	9	0	0.237	1.000	1.000
470	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(8), B3GAT2(2), B3GAT3(4), CHPF(4), CHST11(7), CHST12(5), CHST13(3), CHST14(3), CHST3(2), CHST7(3), CHSY1(8), DSE(18), XYLT1(12), XYLT2(4)	5569022	83	58	83	57	52	11	4	8	8	0	0.562	1.000	1.000
471	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(8), ACOX3(13), FADS2(4), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(17), PLA2G4A(15), PLA2G5(2), PLA2G6(12)	4151614	94	58	94	39	64	6	2	5	16	1	0.0139	1.000	1.000
472	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(4), ACP2(2), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ENPP1(13), ENPP3(13), FLAD1(10), LHPP(1), MTMR1(5), MTMR2(2), MTMR6(2), TYR(9)	6149154	88	58	84	27	59	5	5	4	15	0	0.0168	1.000	1.000
473	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(4), IL6(2), IL6R(3), JAK1(6), JAK2(8), JAK3(11), PIAS3(6), PTPRU(21), REG1A(7), SRC(2), STAT3(9)	6222721	79	58	78	47	47	8	3	9	12	0	0.568	1.000	1.000
474	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(3), BIRC2(6), BIRC3(7), CASP3(2), CASP8(9), CFLAR(4), JUN(1), MAP2K4(4), MAP3K3(8), MAP3K7(1), NFKB1(6), NFKB2(3), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NR2C2(1), RALBP1(3), RIPK1(3), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2)	11085474	80	58	79	49	44	5	8	13	10	0	0.876	1.000	1.000
475	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(5), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(10), GBF1(14), GPLD1(22), KDELR1(1), KDELR3(2)	6715833	74	57	73	41	38	6	3	16	11	0	0.653	1.000	1.000
476	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(9), POLL(8), POLQ(25)	6857926	68	57	67	34	38	7	2	13	8	0	0.375	1.000	1.000
477	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(12), CYP11A1(14), CYP11B2(14), CYP17A1(7), HSD11B1(14), HSD11B2(3), HSD3B1(14), HSD3B2(14)	2827761	92	57	87	54	68	8	1	5	10	0	0.0218	1.000	1.000
478	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(4), CASP9(2), CHUK(2), GH1(3), GHR(40), NFKB1(6), NFKBIA(2), PDPK1(3), PIK3CA(10), PIK3R1(2), RELA(4)	5733304	78	56	72	41	56	7	2	7	5	1	0.636	1.000	1.000
479	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(1), CCL2(2), CCR5(10), CXCL12(3), CXCR4(3), FOS(2), GNAQ(6), JUN(1), MAPK14(5), MAPK8(1), PLCG1(8), PRKCA(8), PTK2B(10), SYT1(23)	5669881	84	56	78	65	55	7	5	11	6	0	0.927	1.000	1.000
480	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(7), F13B(32), HSD17B2(12), HSD17B3(5), HSD17B4(6), HSD17B7(1), HSD3B1(14), HSD3B2(14)	3284012	91	56	85	37	67	6	5	2	11	0	0.0279	1.000	1.000
481	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(4), GRB2(2), HRAS(3), MAPK1(4), MAPK3(4), MAPK7(4), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), NTRK1(16), PIK3CA(10), PIK3R1(2), PLCG1(8), RPS6KA1(8), SHC1(2)	7748010	82	55	79	61	48	12	5	9	7	1	0.970	1.000	1.000
482	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(7), B3GALNT1(6), B3GALT5(1), FUT1(3), FUT2(3), FUT9(30), GLA(2), HEXA(6), HEXB(4), NAGA(5), ST3GAL1(7), ST3GAL2(1), ST8SIA1(1)	4407016	76	55	70	40	46	6	4	14	6	0	0.281	1.000	1.000
483	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(4), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(7), METTL6(1), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), WBSCR22(1)	6177063	72	55	71	38	43	11	2	10	6	0	0.379	1.000	1.000
484	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(6), ACOX1(8), ACOX3(13), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(23), HADHA(6), HSD17B12(3), PECR(1), SCD(3)	5862753	72	55	72	30	45	6	4	8	9	0	0.0175	1.000	1.000
485	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(9), IL22(2), IL22RA1(12), IL22RA2(3), JAK1(6), JAK2(8), JAK3(11), SOCS3(1), STAT1(5), STAT3(9), STAT5A(3), STAT5B(6), TYK2(8)	7467893	83	55	83	49	48	8	6	15	6	0	0.643	1.000	1.000
486	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(5), ACADM(4), ACADS(5), ACADVL(1), ACSL1(8), ACSL3(8), ACSL4(5), CPT1A(14), CPT2(1), EHHADH(6), HADHA(6), PECR(1), SCP2(4), SLC25A20(2)	6951037	70	55	66	32	45	4	3	7	11	0	0.437	1.000	1.000
487	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(22), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), FDXR(9), SHMT1(2)	6572328	81	55	80	49	48	4	5	10	14	0	0.525	1.000	1.000
488	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2), ECHS1(3), EHHADH(6), HADHA(6), SDS(2)	4970858	69	54	65	31	36	9	4	10	10	0	0.140	1.000	1.000
489	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(24), EP300(18), HDAC3(5), IKBKB(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4)	9144236	81	54	81	36	44	10	6	13	8	0	0.363	1.000	1.000
490	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(4), JAK1(6), JAK2(8), JAK3(11), PIAS1(5), PIAS3(6), PTPRU(21), REG1A(7), SOAT1(3)	5593855	71	54	70	30	44	6	2	7	12	0	0.126	1.000	1.000
491	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), CYB5R3(2), GCK(17), GFPT1(4), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(6), HEXB(4), HK1(3), HK2(13), HK3(14), PGM3(1), RENBP(4), UAP1(2)	6960282	77	53	74	40	51	5	2	11	8	0	0.361	1.000	1.000
492	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(22), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2)	6177020	72	52	71	44	42	3	5	9	13	0	0.566	1.000	1.000
493	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(21), EGFR(25), HGS(5), RAB5A(2), TF(16), TFRC(4)	5260335	76	52	76	45	48	5	5	8	10	0	0.819	1.000	1.000
494	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(22), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2)	6177020	72	52	71	44	42	3	5	9	13	0	0.566	1.000	1.000
495	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(8), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(8), MAPK14(5), NFATC1(16), NFATC2(11), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	4954480	84	52	81	51	51	10	4	5	14	0	0.518	1.000	1.000
496	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(15), AMT(1), ATIC(5), DHFR(2), FTCD(3), GART(11), MTFMT(2), MTHFD1(10), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(11), SHMT1(2), SHMT2(3), TYMS(1)	7766009	73	52	71	41	49	5	3	8	8	0	0.553	1.000	1.000
497	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A1(12), ATP6V0A4(22), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(1), ATP6V1C2(7), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2)	6177020	72	52	71	44	42	3	5	9	13	0	0.566	1.000	1.000
498	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(7), FUT1(3), FUT2(3), FUT9(30), GLA(2), HEXA(6), HEXB(4), NAGA(5), ST3GAL1(7), ST3GAL2(1), ST3GAL4(2), ST8SIA1(1)	4149472	71	51	65	31	42	6	2	14	7	0	0.0857	1.000	1.000
499	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(22), AOC2(9), AOC3(10), CES1(21), ESD(3)	2470669	65	50	62	38	51	2	4	4	4	0	0.423	1.000	1.000
500	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(4), CD3D(7), CD3E(2), CD3G(1), GZMB(3), HLA-A(3), ICAM1(2), ITGAL(28), ITGB2(16), PRF1(11)	3572294	77	50	76	31	46	7	2	5	17	0	0.0190	1.000	1.000
501	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(6), ARHGAP5(13), ARHGDIB(4), CASP1(10), CASP10(6), CASP3(2), CASP8(9), CASP9(2), CYCS(1), GZMB(3), JUN(1), PRF1(11)	5303508	68	50	66	33	45	5	2	11	5	0	0.604	1.000	1.000
502	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(21), EGFR(25), ERBB3(5), NRG1(15), UBE2D1(1)	4244049	67	50	67	42	46	2	3	7	9	0	0.919	1.000	1.000
503	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(2), B3GNT7(6), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), CHST1(10), CHST2(5), CHST4(10), CHST6(4), FUT8(8), ST3GAL1(7), ST3GAL2(1), ST3GAL3(2), ST3GAL4(2)	5109356	69	50	68	44	43	13	3	5	5	0	0.482	1.000	1.000
504	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(10), ACYP1(1), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), GCDH(6), HADHA(6), ITGB1BP3(1), PNPLA3(3), SH3GLB1(2), YOD1(1)	10696752	68	50	67	41	35	10	5	13	5	0	0.894	1.000	1.000
505	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(6), CLOCK(3), CRY1(6), CRY2(6), CSNK1D(3), CSNK1E(5), NPAS2(7), NR1D1(1), PER1(8), PER2(11), PER3(12)	6966190	68	50	65	44	46	5	1	6	10	0	0.875	1.000	1.000
506	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(6), BCL2(2), CASP3(2), CASP9(2), CYCS(1), DAXX(9), FAS(6), FASLG(15), HSPB1(2), HSPB2(1), IL1A(5), MAPKAPK2(5), MAPKAPK3(5), TNF(1)	4666306	66	50	64	29	44	4	2	7	9	0	0.149	1.000	1.000
507	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(24), EP300(18), ESR1(6), MAPK1(4), MAPK3(4), PELP1(12), SRC(2)	6017686	70	50	70	33	41	7	5	12	5	0	0.501	1.000	1.000
508	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), LTA(4), MAP3K1(4), MAP3K14(6), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNFAIP3(2), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5)	9141016	62	50	62	50	40	7	1	6	8	0	0.986	1.000	1.000
509	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(2), JUN(1), MAPK3(4), OPRK1(24), POLR2A(13), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	5269149	72	49	70	61	51	4	4	6	7	0	0.979	1.000	1.000
510	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(6), FARSA(8), FARSB(5), GOT1(6), GOT2(6), PAH(12), TAT(19), YARS(3), YARS2(2)	3576174	67	49	63	26	43	7	2	5	10	0	0.0268	1.000	1.000
511	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(8), ANKRD1(1), ATF3(1), CYR61(2), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(4), IFRD1(2), IL18(3), IL1A(5), IL1R1(13), JUND(1), MYOG(3), NR4A3(9), WDR1(6)	4353087	62	49	59	27	41	5	2	5	9	0	0.263	1.000	1.000
512	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(6), MAPK14(5), MAPK8(1), NFKB1(6), RELA(4), TNFRSF13B(10), TNFRSF17(7), TNFSF13B(2), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4)	5891344	62	49	62	28	43	7	0	9	3	0	0.290	1.000	1.000
513	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(27), CD34(4), CD3D(7), CD3E(2), CD3G(1), CD4(8), CD58(1), CD8A(2), CSF3(4), IL3(3), IL6(2), IL8(1), KITLG(11)	2516518	73	48	66	31	51	4	2	8	8	0	0.0420	1.000	1.000
514	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(4), GRB2(2), IL2RG(3), IL4(1), IL4R(16), IRS1(5), JAK1(6), JAK3(11), RPS6KB1(3), SHC1(2), STAT6(8)	6047106	61	48	61	26	34	9	3	8	7	0	0.151	1.000	1.000
515	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(3), CCR3(10), CD4(8), HLA-DRA(12), IL1B(8), IL4(1), IL5(4), IL5RA(17), IL6(2)	2191713	65	48	59	33	49	1	1	4	10	0	0.0511	1.000	1.000
516	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(5), CAMK1G(11), HDAC9(44), MEF2A(3), MEF2B(2), MEF2C(4), MEF2D(6), MYOD1(1)	3048921	76	48	67	37	61	5	2	3	5	0	0.230	1.000	1.000
517	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(4), DPM2(1), GRB2(2), HRAS(3), KLK2(5), NTRK1(16), PIK3CA(10), PIK3R1(2), PLCG1(8), PRKCA(8), SHC1(2), SOS1(10)	6378128	71	48	69	39	40	9	3	10	8	1	0.782	1.000	1.000
518	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(5), GNAS(25), GNB1(1), PRKACB(4), PRKACG(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(8)	3895289	67	47	64	41	43	9	3	6	6	0	0.861	1.000	1.000
519	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(4), CYP51A1(1), DHCR24(2), DHCR7(10), FDPS(3), GGCX(2), GGPS1(1), HMGCR(12), HSD17B7(1), IDI1(1), IDI2(1), LSS(3), MVD(1), MVK(2), NQO1(2), NSDHL(3), PMVK(2), SC5DL(2), SQLE(3), TM7SF2(5)	7895430	61	47	57	35	27	13	3	10	8	0	0.697	1.000	1.000
520	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(4), CHPT1(1), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(7), METTL6(1), PCYT1A(3), PCYT1B(9), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(3), PRMT8(11), WBSCR22(1)	5756909	63	47	62	31	38	9	4	7	5	0	0.341	1.000	1.000
521	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(15), AMT(1), ATIC(5), DHFR(2), GART(11), MTHFD1(10), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(11), SHMT1(2), SHMT2(3), TYMS(1)	7333319	68	47	66	34	45	5	3	8	7	0	0.337	1.000	1.000
522	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(15), CDC25A(8), CDC25B(4), CDC25C(5), CHEK1(2), MYT1(21), WEE1(2)	5643058	57	46	55	26	38	4	2	6	7	0	0.498	1.000	1.000
523	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(6), ACO2(5), AFMID(2), CS(2), GRHPR(1), HAO1(8), HAO2(14), HYI(1), MDH1(3), MDH2(3), MTHFD1(10), MTHFD1L(2), MTHFD2(2)	5495881	59	46	56	37	35	4	3	7	10	0	0.672	1.000	1.000
524	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(7), CHST12(5), CHST13(3), PAPSS1(4), PAPSS2(5), SULT1A1(14), SULT1A2(2), SULT1E1(16), SULT2A1(9), SULT2B1(7), SUOX(4)	3740688	76	46	73	38	57	5	0	6	8	0	0.168	1.000	1.000
525	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL2(5), IFNAR1(2), IFNAR2(14), IFNB1(6), MAPK8(1), NFKB1(6), RELA(4), TNFRSF11A(5), TNFSF11(5), TRAF6(4)	4538099	54	46	52	28	36	3	1	7	7	0	0.615	1.000	1.000
526	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(6), JAK1(6), PTPRU(21), REG1A(7), STAT1(5), STAT2(6), TYK2(8)	5142435	61	46	60	30	35	5	1	8	12	0	0.184	1.000	1.000
527	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(8), CHAT(17), CHKA(2), PCYT1A(3), PDHA1(4), PDHA2(20), PEMT(2), SLC18A3(2)	2813532	58	45	54	29	41	7	1	2	7	0	0.138	1.000	1.000
528	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(6), IFNG(4), IL10(3), IL12A(4), IL12B(3), IL13(2), IL15(3), IL16(12), IL18(3), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL8(1), IL9(1), LTA(4), TNF(1)	4046903	67	45	64	37	46	3	2	3	13	0	0.141	1.000	1.000
529	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(9), DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), HSD3B7(5), PON1(21), PON2(2), RDH11(1), RDH12(2), RDH13(3)	3707329	65	45	64	32	47	4	1	6	7	0	0.131	1.000	1.000
530	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(6), ACO2(5), CS(2), GRHPR(1), HAO1(8), HAO2(14), HYI(1), MDH1(3), MDH2(3), MTHFD1(10), MTHFD1L(2), MTHFD2(2)	5247530	57	44	54	33	34	4	2	7	10	0	0.552	1.000	1.000
531	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(13), CDO1(6), CSAD(6), GAD1(13), GAD2(9), GGT1(8)	2324125	55	44	53	31	34	7	4	5	5	0	0.456	1.000	1.000
532	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BET1L(1), BNIP1(4), GOSR1(2), GOSR2(1), SEC22B(5), SNAP25(8), SNAP29(2), STX10(1), STX11(3), STX12(1), STX16(2), STX17(1), STX19(2), STX2(4), STX3(1), STX4(1), STX5(4), STX6(2), TSNARE1(5), VAMP1(1), VAMP3(1), VAMP4(1), VAMP7(5), VAMP8(1), VTI1A(1), VTI1B(1)	6788296	62	44	59	33	36	5	1	11	9	0	0.412	1.000	1.000
533	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), MAP3K1(4), MAP3K14(6), NFKB1(6), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(5), TRAF6(4)	7395344	47	43	47	35	29	7	1	5	5	0	0.962	1.000	1.000
534	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(10), CS(2), MDH1(3), ME1(20), PC(14), PDHA1(4), SLC25A11(4)	3821198	57	43	55	29	36	6	2	8	4	1	0.242	1.000	1.000
535	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), CREBBP(24), DFFA(2), DFFB(2), GZMA(13), GZMB(3), HMGB2(1), PRF1(11), SET(3)	4347679	62	43	60	23	33	6	6	10	7	0	0.167	1.000	1.000
536	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2)	3262894	52	42	49	22	26	6	4	8	8	0	0.112	1.000	1.000
537	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(8), CYP2E1(13), NR1I3(6), PTGS1(20), PTGS2(13)	2211448	60	42	58	34	45	5	0	2	8	0	0.202	1.000	1.000
538	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(5), ALDH1A2(14), ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH9A1(2)	3262894	52	42	49	22	26	6	4	8	8	0	0.112	1.000	1.000
539	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(10), HS3ST2(9), HS3ST3A1(6), HS3ST3B1(2), XYLT1(12), XYLT2(4)	2621689	47	42	47	41	30	6	0	7	4	0	0.863	1.000	1.000
540	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(10), HS3ST2(9), HS3ST3A1(6), HS3ST3B1(2), XYLT1(12), XYLT2(4)	2621689	47	42	47	41	30	6	0	7	4	0	0.863	1.000	1.000
541	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(6), BAK1(1), BAX(3), BCL2(2), BIK(2), BIRC2(6), BIRC3(7), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), DIABLO(2)	5529917	51	42	50	18	25	4	6	6	10	0	0.259	1.000	1.000
542	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(4), IFNG(4), IFNGR1(3), JAK1(6), JAK2(8), PLA2G2A(2), PTPRU(21), REG1A(7), STAT1(5)	4678479	60	42	59	23	35	3	1	7	14	0	0.0989	1.000	1.000
543	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(9), CDKN1A(3), EPO(5), EPOR(1), GRIN1(8), HIF1A(4), JAK2(8), NFKB1(6), NFKBIA(2), RELA(4)	5137112	50	41	49	24	22	6	5	7	10	0	0.576	1.000	1.000
544	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(17), HK1(3), HK2(13), HK3(14), IMPA1(1), IMPA2(4), ISYNA1(1), PGM1(6), PGM3(1), TGDS(1)	4777313	61	41	59	37	43	5	2	5	6	0	0.412	1.000	1.000
545	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(3), LDLR(17), MBTPS1(7), MBTPS2(4), SCAP(10), SREBF1(5), SREBF2(10)	4864718	56	41	54	31	36	3	4	9	4	0	0.482	1.000	1.000
546	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(24), CKM(3), FBL(1), GPT(3), LDHA(4), LDHB(2), LDHC(5), MAPK14(5), NCL(6)	3687704	53	41	51	26	36	4	6	4	3	0	0.346	1.000	1.000
547	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNAR2(14), IFNB1(6), JAK1(6), STAT1(5), STAT2(6), TYK2(8)	4428722	48	40	47	21	29	3	2	7	7	0	0.206	1.000	1.000
548	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CBS(7), CTH(1), GGT1(8), MARS(7), MARS2(4), MAT1A(6), MAT2B(1), PAPSS1(4), PAPSS2(5), SCLY(4), SEPHS1(2)	5107394	54	40	54	23	33	4	4	5	8	0	0.104	1.000	1.000
549	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(5), IL4R(16), JAK1(6), JAK2(8), TYK2(8)	4290908	48	40	48	23	31	2	2	8	5	0	0.492	1.000	1.000
550	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(5), IL4R(16), JAK1(6), JAK2(8), TYK2(8)	4290908	48	40	48	23	31	2	2	8	5	0	0.492	1.000	1.000
551	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(6), FOS(2), FYN(7), JUN(1), MAPK14(5), THBS1(30)	3037660	53	40	52	33	34	2	2	6	9	0	0.854	1.000	1.000
552	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(10), ACO1(6), ACO2(5), ACSS1(2), ACSS2(4), FH(3), IDH1(16), IDH2(1), MDH1(3), MDH2(3)	5489195	53	39	42	34	37	0	1	7	8	0	0.712	1.000	1.000
553	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3D(7), CD3E(2), CD3G(1), IFNG(4), IL2(4), IL2RA(5), IL4(1), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TGFBR3(8), TOB1(3), TOB2(3)	4318369	57	39	57	27	43	2	1	1	10	0	0.189	1.000	1.000
554	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(11), ALDH2(7), ALDH3A1(8), ALDH3A2(3), ALDH7A1(9), ALDH9A1(2), MIOX(4), UGDH(1)	3473047	47	38	45	24	23	6	6	5	7	0	0.342	1.000	1.000
555	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(1), HMOX1(1), IL10(3), IL10RA(9), IL1A(5), IL6(2), JAK1(6), STAT1(5), STAT3(9), STAT5A(3), TNF(1)	5005797	47	38	46	28	25	5	5	6	6	0	0.446	1.000	1.000
556	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(8), CD8A(2), CSF1(12), CSF2(2), CSF3(4), EPO(5), IL11(3), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(4), IL8(1), IL9(1)	2477876	56	38	54	35	38	3	1	6	8	0	0.300	1.000	1.000
557	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(17), HK1(3), HK2(13), HK3(14), IMPA1(1), PGM1(6), PGM3(1), TGDS(1)	4196442	56	38	54	32	40	5	2	4	5	0	0.351	1.000	1.000
558	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(10), FDPS(3), HMGCR(12), HMGCS1(3), IDI1(1), LSS(3), MVD(1), MVK(2), NSDHL(3), PMVK(2), SC5DL(2), SQLE(3)	5390867	46	37	42	26	19	9	2	9	7	0	0.819	1.000	1.000
559	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(3), HADH(2), HADHA(6), HADHB(5), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(4), PPT2(5)	3483135	39	37	38	16	21	4	4	6	4	0	0.333	1.000	1.000
560	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(9), POLR2A(13), POLR2B(12), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLRMT(3)	5493222	46	37	44	23	27	4	2	7	6	0	0.429	1.000	1.000
561	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(6), JAK2(8), JAK3(11), MAPK1(4), MAPK3(4), STAT3(9), TYK2(8)	4773442	50	37	50	36	26	7	4	8	5	0	0.898	1.000	1.000
562	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(20), GNA12(3), PRKACB(4), PRKACG(11), PRKAG1(3), PRKAR2A(1), PRKAR2B(5)	4144088	47	35	47	28	31	4	1	5	6	0	0.731	1.000	1.000
563	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(16), EIF2AK4(14), EIF2B5(2), EIF2S1(1), EIF2S3(1), EIF5(2), GSK3B(3), PPP1CA(1)	4761473	40	35	39	19	21	2	1	13	3	0	0.752	1.000	1.000
564	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA4(2), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC2(2), PSMC3(3), PSMD1(6), PSMD12(2), PSMD13(3), PSMD2(4), PSMD6(1)	6614597	41	35	40	19	24	4	2	7	4	0	0.470	1.000	1.000
565	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(6), ADORA2A(3), ADORA2B(1), ADORA3(15), LTB4R(1), P2RY1(5), P2RY2(8), P2RY6(2)	2447299	41	35	41	33	25	6	2	5	3	0	0.321	1.000	1.000
566	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(3), NRF1(7), TAX1BP3(1), UBE2A(1), UBE2D1(1), UBE2D3(2), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(2), UBE2J1(1), UBE2J2(8), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(7)	4338873	43	35	41	19	29	5	2	4	3	0	0.387	1.000	1.000
567	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(10), FDPS(3), HMGCR(12), IDI1(1), LSS(3), MVD(1), MVK(2), NQO1(2), NQO2(1), PMVK(2), SC5DL(2), SQLE(3)	4510798	42	34	38	24	17	7	1	9	8	0	0.767	1.000	1.000
568	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(5), B3GALT1(14), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT1(3), FUT2(3), FUT3(8), ST3GAL3(2), ST3GAL4(2)	2945057	41	34	41	28	28	5	1	3	4	0	0.642	1.000	1.000
569	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(14), ENO1(4), GPI(3), HK1(3), PFKL(4), PGK1(2), PKLR(13), TPI1(1)	3769382	44	33	41	21	30	4	1	4	5	0	0.0672	1.000	1.000
570	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(6), ACO2(5), FH(3), IDH1(16), IDH2(1), MDH1(3), MDH2(3)	3682676	37	33	26	19	27	0	1	4	5	0	0.426	1.000	1.000
571	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), CTSD(3), ESR1(6), GREB1(19), HSPB1(2), HSPB2(1), MTA1(2), MTA3(2), PDZK1(4), TUBA8(5)	4383109	46	31	45	27	32	2	4	4	4	0	0.432	1.000	1.000
572	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(5), ADSS(1), DHFR(2), IMPDH1(4), MTHFD2(2), POLB(1), POLD1(7), POLG(9), PRPS2(2), RRM1(3), SRM(1)	5100767	37	31	37	32	21	4	2	6	4	0	0.972	1.000	1.000
573	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(8), CDC25B(4), CDC25C(5), CSK(1), GRB2(2), PRKCA(8), PTPRA(9), SRC(2)	3808951	39	31	38	24	25	5	1	4	4	0	0.658	1.000	1.000
574	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(3), HMGCS2(21), OXCT1(4), OXCT2(5)	2932292	43	30	40	20	25	5	2	6	5	0	0.441	1.000	1.000
575	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA4(2), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC3(3), RPN2(4), UBE2A(1), UBE3A(7)	5316782	35	30	35	20	22	3	2	5	3	0	0.719	1.000	1.000
576	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(5), ALAS1(2), ALAS2(5), CPO(4), FECH(3), GATA1(4), HBA1(1), HBB(7), HMBS(1), UROS(1)	3167948	33	29	32	18	25	2	0	2	4	0	0.380	1.000	1.000
577	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(8), DHRS3(4), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), PNPLA3(3), SH3GLB1(2)	6829551	33	29	33	21	17	3	3	7	3	0	0.923	1.000	1.000
578	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(2), CSF1(12), IL1B(8), MST1(2), MST1R(11), TNF(1)	2689219	36	29	35	31	25	3	1	4	3	0	0.955	1.000	1.000
579	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(3), BIRC3(7), CASP8(9), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2)	3370895	33	29	33	14	22	1	2	3	5	0	0.274	1.000	1.000
580	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(6), CLOCK(3), CRY1(6), CRY2(6), CSNK1E(5), PER1(8)	3461230	34	28	34	18	23	3	1	3	4	0	0.668	1.000	1.000
581	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(4), CDKN1B(1), CUL1(5), E2F1(5), RB1(10), SKP2(2), TFDP1(2), UBE2M(1)	3523090	30	28	30	13	12	2	4	4	6	2	0.417	1.000	1.000
582	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(28), RANGAP1(3)	3496012	32	28	30	14	21	2	1	3	5	0	0.685	1.000	1.000
583	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(5), FUT1(3), FUT2(3), FUT3(8), FUT5(8), FUT6(4), ST3GAL3(2)	2055050	33	27	33	20	18	5	2	3	5	0	0.324	1.000	1.000
584	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(4), DFFA(2), DFFB(2), GZMB(3), HMGB1(1), HMGB2(1), TOP2A(11), TOP2B(9)	3636220	35	27	34	13	23	2	4	3	3	0	0.397	1.000	1.000
585	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(6), ACAA2(1), ACAT2(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(5), SDS(2)	3430311	30	27	29	17	19	4	1	2	4	0	0.683	1.000	1.000
586	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), FUT8(8), ST3GAL1(7), ST3GAL2(1), ST3GAL3(2), ST3GAL4(2)	3225915	31	27	31	19	16	6	2	4	3	0	0.724	1.000	1.000
587	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(2), CSF1(12), IL6(2), LDLR(17), LPL(6)	2199996	39	26	38	19	24	6	2	6	1	0	0.305	1.000	1.000
588	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(2), CDC25A(8), CDC25B(4), CDC25C(5), CDK7(2), MNAT1(2), SHH(3), XPO1(3)	3575779	29	26	29	11	17	3	3	5	1	0	0.358	1.000	1.000
589	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(2), JUN(1), KEAP1(2), MAFG(2), MAPK1(4), MAPK14(5), MAPK8(1), NFE2L2(4), PRKCA(8)	3631805	29	25	27	16	18	2	0	4	5	0	0.670	1.000	1.000
590	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HBXIP(1), HRAS(3), PTK2B(10), SHC1(2), SOS1(10), SRC(2)	3610898	30	25	30	26	21	2	0	5	2	0	0.989	1.000	1.000
591	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(8), PLCG1(8), PRKCA(8), PTK2B(10)	2772971	34	25	33	31	26	4	1	0	3	0	0.828	1.000	1.000
592	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(5), MTMR2(2), MTMR6(2), NFS1(4), TPK1(10)	2623868	24	23	24	11	15	1	2	0	6	0	0.640	1.000	1.000
593	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(26), PNPO(1), PSAT1(3)	1998305	30	23	28	21	24	1	1	3	1	0	0.820	1.000	1.000
594	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(2), FH(3), IDH2(1), MDH1(3), OGDH(8), SDHA(3)	3888616	25	23	25	22	16	0	2	4	3	0	0.962	1.000	1.000
595	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(4), NDUFA4(1), NDUFB2(2), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(3), NDUFV2(1)	2870050	23	23	23	10	16	1	0	5	1	0	0.578	1.000	1.000
596	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(5), ALAS1(2), ALAS2(5), CPOX(4), FECH(3), HMBS(1), PPOX(4), UROS(1)	3103794	25	22	25	11	16	2	1	3	3	0	0.350	1.000	1.000
597	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA4(2), PSMA5(3), PSMA6(4), PSMB1(1), PSMB10(2), PSMB2(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMB8(4)	3612641	26	22	26	10	16	1	2	5	2	0	0.369	1.000	1.000
598	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(10), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(8)	1314863	30	22	29	22	21	3	0	3	3	0	0.619	1.000	1.000
599	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ACYP1(1), ECHS1(3), EHHADH(6), GCDH(6), HADHA(6), SDS(2)	3202483	25	21	24	11	16	4	0	3	2	0	0.365	1.000	1.000
600	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(7), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(4), ST8SIA1(1)	2327954	21	21	21	12	13	2	1	4	1	0	0.518	1.000	1.000
601	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(9), EPHX2(5), HSD3B7(5), RDH11(1), RDH12(2), RDH13(3)	1976941	25	21	25	18	18	2	2	0	3	0	0.641	1.000	1.000
602	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(2), FURIN(10), NOTCH1(9), PSEN1(1)	3769426	23	21	23	21	11	4	2	6	0	0	0.950	1.000	1.000
603	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(6), APOBEC1(3), APOBEC2(5), APOBEC3B(4), APOBEC3C(2), APOBEC3F(3)	3032048	23	19	23	28	17	2	2	2	0	0	0.998	1.000	1.000
604	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(3), ECHS1(3), EHHADH(6), HADHA(6), SDS(2)	1985863	20	18	18	10	13	3	0	2	2	0	0.438	1.000	1.000
605	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), BCKDK(2), CBS(7), CTH(1), MUT(6)	2077403	18	18	18	10	11	2	1	3	1	0	0.669	1.000	1.000
606	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), KARS(3)	2838208	19	17	19	8	17	0	0	1	1	0	0.526	1.000	1.000
607	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(2), BMPR1B(4), BMPR2(6)	2580159	17	17	17	10	10	2	1	2	2	0	0.730	1.000	1.000
608	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(4), GSTZ1(1), HGD(13)	920046	18	16	18	17	12	2	2	0	2	0	0.922	1.000	1.000
609	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(6), ARG1(2), GLS(2), GLUD1(2), OAT(4), PRODH(2)	2231096	18	14	18	14	6	4	3	3	2	0	0.939	1.000	1.000
610	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(20)	750317	22	14	21	13	15	2	1	3	1	0	0.608	1.000	1.000
611	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(4)	2017762	9	9	9	11	3	0	1	0	5	0	0.993	1.000	1.000
612	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(3)	1740546	9	9	9	7	6	1	1	1	0	0	0.820	1.000	1.000
613	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(6)	1269526	8	8	8	10	6	0	1	1	0	0	0.967	1.000	1.000
614	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(1), UGDH(1), UXS1(4)	1581661	8	8	8	10	2	0	1	0	5	0	0.992	1.000	1.000
615	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(3), IDI1(1), SQLE(3)	1299480	7	7	7	5	4	1	1	1	0	0	0.777	1.000	1.000
616	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5)	873747	5	5	5	5	5	0	0	0	0	0	0.859	1.000	1.000
