Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.042 0.252 0.371 5.0 -0.557 12.0 17.0 IHH 0.005 0.142 0.246 6.0 -0.464 4.0 10.0 SHH Np/Cholesterol/GAS1 -0.049 0.127 -9999.0 0.0 -0.266 18.0 18.0 LRPAP1 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.049 0.126 0.265 18.0 -9999.0 0.0 18.0 SMO/beta Arrestin2 -0.077 0.182 -9999.0 0.0 -0.417 7.0 7.0 SMO -0.085 0.181 0.26 1.0 -0.37 14.0 15.0 AKT1 -0.041 0.132 -9999.0 0.0 -0.635 2.0 2.0 ARRB2 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.081 0.242 2.0 -0.426 2.0 4.0 ADRBK1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.083 0.179 0.259 1.0 -0.365 14.0 15.0 STIL -0.068 0.147 0.279 3.0 -0.295 10.0 13.0 DHH N/PTCH2 0.041 0.079 0.187 10.0 -0.308 2.0 12.0 DHH N/PTCH1 -0.01 0.141 0.322 1.0 -0.288 11.0 12.0 PIK3CA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.035 0.104 0.242 9.0 -0.426 2.0 11.0 PTHLH -0.099 0.354 0.513 2.0 -0.858 12.0 14.0 determination of left/right symmetry -0.083 0.179 0.259 1.0 -0.365 14.0 15.0 PIK3R1 0.006 0.091 0.242 1.0 -0.426 3.0 4.0 skeletal system development -0.097 0.35 0.512 2.0 -0.847 12.0 14.0 IHH N/Hhip -0.025 0.168 0.22 5.0 -0.336 15.0 20.0 DHH N/Hhip -0.002 0.147 0.201 11.0 -0.283 14.0 25.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.083 0.179 0.259 1.0 -0.365 14.0 15.0 pancreas development -0.031 0.182 0.242 7.0 -0.426 12.0 19.0 HHAT 0.012 0.072 -9999.0 0.0 -0.426 2.0 2.0 PI3K 0.018 0.07 0.187 1.0 -0.308 3.0 4.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.003 0.114 0.242 1.0 -0.426 5.0 6.0 somite specification -0.083 0.179 0.259 1.0 -0.365 14.0 15.0 SHH Np/Cholesterol/PTCH1 -0.062 0.15 0.315 2.0 -0.287 12.0 14.0 SHH Np/Cholesterol/PTCH2 -0.03 0.117 0.229 2.0 -0.248 15.0 17.0 SHH Np/Cholesterol/Megalin -0.046 0.105 -9999.0 0.0 -0.244 15.0 15.0 SHH -0.067 0.134 0.165 4.0 -0.319 15.0 19.0 catabolic process -0.023 0.152 0.263 2.0 -0.323 13.0 15.0 SMO/Vitamin D3 -0.086 0.168 0.338 2.0 -0.329 13.0 15.0 SHH Np/Cholesterol/Hhip -0.062 0.158 0.19 5.0 -0.277 23.0 28.0 LRP2 0.007 0.035 0.242 1.0 -9999.0 0.0 1.0 receptor-mediated endocytosis -0.089 0.163 0.296 2.0 -0.39 6.0 8.0 SHH Np/Cholesterol/BOC -0.038 0.116 0.152 1.0 -0.243 17.0 18.0 SHH Np/Cholesterol/CDO -0.042 0.113 0.154 1.0 -0.239 18.0 19.0 mesenchymal cell differentiation 0.062 0.157 0.275 23.0 -0.188 5.0 28.0 mol:Vitamin D3 -0.057 0.161 0.33 3.0 -0.288 12.0 15.0 IHH N/PTCH2 0.025 0.094 0.22 2.0 -0.275 4.0 6.0 CDON 0.014 0.098 0.242 3.0 -0.426 3.0 6.0 IHH N/PTCH1 -0.007 0.168 0.332 3.0 -0.325 13.0 16.0 Megalin/LRPAP1 0.032 0.021 0.187 1.0 -9999.0 0.0 1.0 PTCH2 0.028 0.036 0.242 2.0 -9999.0 0.0 2.0 SHH Np/Cholesterol -0.054 0.098 -9999.0 0.0 -0.243 15.0 15.0 PTCH1 -0.023 0.152 0.263 2.0 -0.324 13.0 15.0 HHIP -0.031 0.182 0.242 7.0 -0.426 12.0 19.0