Correlation between gene mutation status and molecular subtypes
Adrenocortical Carcinoma (Primary solid tumor)
15 January 2014 | analyses__2014_01_15
Maintainer Information
Citation Information
doi:10.7908/C17M06D9
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2014): Correlation between gene mutation status and molecular subtypes. Broad Institute of MIT and Harvard. doi:10.7908/C17M06D9
Overview
Introduction

This pipeline computes the correlation between significantly recurrent gene mutations and molecular subtypes.

Summary

Testing the association between mutation status of 9 genes and 8 molecular subtypes across 90 patients, 4 significant findings detected with P value < 0.05 and Q value < 0.25.

- CTNNB1 mutation correlated to 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', and 'MIRSEQ_CNMF'.

- KRTAP4-5 mutation correlated to 'METHLYATION_CNMF'.

Results
Overview of the results

Table 1. Get Full Table Overview of the association between mutation status of 9 genes and 8 molecular subtypes. Shown in the table are P values (Q values). Thresholded by P value < 0.05 and Q value < 0.25, 4 significant findings detected.

|  | Clinical Features | CN CNMF | METHLYATION CNMF | MRNASEQ CNMF | MRNASEQ CHIERARCHICAL | MIRSEQ CNMF | MIRSEQ CHIERARCHICAL | MIRSEQ MATURE CNMF | MIRSEQ MATURE CHIERARCHICAL
| nMutated (%) | nWild-Type | Chi-square test | Chi-square test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test
CTNNB1 | 13 (14%) | 77 | 0.51 (1.00) | 0.0755 (1.00) | 0.000319 (0.0226) | 0.000102 (0.00737) | 0.000609 (0.0426) | 0.541 (1.00) | 0.00882 (0.582) | 0.456 (1.00)
KRTAP4-5 | 4 (4%) | 86 | 0.538 (1.00) | 0.000785 (0.0541) | 1 (1.00) | 1 (1.00) | 0.781 (1.00) | 0.213 (1.00) | 0.797 (1.00) | 0.234 (1.00)
MUC5B | 16 (18%) | 74 | 0.134 (1.00) | 0.207 (1.00) | 0.218 (1.00) | 0.364 (1.00) | 0.167 (1.00) | 0.409 (1.00) | 0.393 (1.00) | 0.465 (1.00)
CRIPAK | 11 (12%) | 79 | 0.0539 (1.00) | 0.533 (1.00) | 0.257 (1.00) | 0.162 (1.00) | 0.588 (1.00) | 0.688 (1.00) | 0.655 (1.00) | 0.623 (1.00)
TP53 | 15 (17%) | 75 | 0.00857 (0.574) | 0.444 (1.00) | 0.0122 (0.767) | 0.0784 (1.00) | 0.00968 (0.629) | 0.087 (1.00) | 0.0321 (1.00) | 0.0377 (1.00)
MEN1 | 7 (8%) | 83 | 0.427 (1.00) | 0.0201 (1.00) | 0.352 (1.00) | 0.0698 (1.00) | 0.666 (1.00) | 0.514 (1.00) | 0.771 (1.00) | 0.536 (1.00)
PRKAR1A | 6 (7%) | 84 | 0.958 (1.00) | 0.702 (1.00) | 0.188 (1.00) | 0.878 (1.00) | 0.855 (1.00) | 1 (1.00) | 0.3 (1.00) | 0.854 (1.00)
ATN1 | 4 (4%) | 86 | 0.0602 (1.00) | 0.657 (1.00) | 0.877 (1.00) | 1 (1.00) | 0.781 (1.00) | 0.691 (1.00) | 0.797 (1.00) | 0.709 (1.00)
DMKN | 3 (3%) | 87 | 0.693 (1.00) | 0.344 (1.00) | 0.617 (1.00) | 0.262 (1.00) | 0.00736 (0.501) | 1 (1.00) | 0.0107 (0.686) | 1 (1.00)

'CTNNB1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.51 (Chi-square test), Q value = 1

Table S1. Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #1: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 31 | 23 | 15 | 10 | 9
CTNNB1 MUTATED | 6 | 2 | 3 | 2 | 0
CTNNB1 WILD-TYPE | 25 | 21 | 12 | 8 | 9

'CTNNB1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0755 (Chi-square test), Q value = 1

Table S2. Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #2: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 17 | 11 | 21 | 18 | 11
CTNNB1 MUTATED | 4 | 4 | 2 | 0 | 2
CTNNB1 WILD-TYPE | 13 | 7 | 19 | 18 | 9

'CTNNB1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.000319 (Fisher's exact test), Q value = 0.023

Table S3. Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #3: 'MRNASEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 23 | 14 | 17 | 23
CTNNB1 MUTATED | 7 | 5 | 0 | 0
CTNNB1 WILD-TYPE | 16 | 9 | 17 | 23

Figure S1. Get High-res Image Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #3: 'MRNASEQ_CNMF'

'CTNNB1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.000102 (Fisher's exact test), Q value = 0.0074

Table S4. Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 22 | 32 | 23
CTNNB1 MUTATED | 9 | 0 | 3
CTNNB1 WILD-TYPE | 13 | 32 | 20

Figure S2. Get High-res Image Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'

'CTNNB1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.000609 (Fisher's exact test), Q value = 0.043

Table S5. Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 37 | 16 | 25
CTNNB1 MUTATED | 5 | 7 | 0
CTNNB1 WILD-TYPE | 32 | 9 | 25

Figure S3. Get High-res Image Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

'CTNNB1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.541 (Fisher's exact test), Q value = 1

Table S6. Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #6: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 26 | 9 | 43
CTNNB1 MUTATED | 4 | 0 | 8
CTNNB1 WILD-TYPE | 22 | 9 | 35

'CTNNB1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.00882 (Fisher's exact test), Q value = 0.58

Table S7. Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 38 | 18 | 22
CTNNB1 MUTATED | 6 | 6 | 0
CTNNB1 WILD-TYPE | 32 | 12 | 22

Figure S4. Get High-res Image Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

'CTNNB1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.456 (Fisher's exact test), Q value = 1

Table S8. Gene #1: 'CTNNB1 MUTATION STATUS' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 41 | 10 | 27
CTNNB1 MUTATED | 8 | 0 | 4
CTNNB1 WILD-TYPE | 33 | 10 | 23

'MUC5B MUTATION STATUS' versus 'CN_CNMF'

P value = 0.134 (Chi-square test), Q value = 1

Table S9. Gene #2: 'MUC5B MUTATION STATUS' versus Molecular Subtype #1: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 31 | 23 | 15 | 10 | 9
MUC5B MUTATED | 4 | 4 | 1 | 3 | 4
MUC5B WILD-TYPE | 27 | 19 | 14 | 7 | 5

'MUC5B MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.207 (Chi-square test), Q value = 1

Table S10. Gene #2: 'MUC5B MUTATION STATUS' versus Molecular Subtype #2: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 17 | 11 | 21 | 18 | 11
MUC5B MUTATED | 2 | 2 | 3 | 3 | 5
MUC5B WILD-TYPE | 15 | 9 | 18 | 15 | 6

'MUC5B MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.218 (Fisher's exact test), Q value = 1

Table S11. Gene #2: 'MUC5B MUTATION STATUS' versus Molecular Subtype #3: 'MRNASEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 23 | 14 | 17 | 23
MUC5B MUTATED | 3 | 1 | 6 | 5
MUC5B WILD-TYPE | 20 | 13 | 11 | 18

'MUC5B MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.364 (Fisher's exact test), Q value = 1

Table S12. Gene #2: 'MUC5B MUTATION STATUS' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 22 | 32 | 23
MUC5B MUTATED | 2 | 8 | 5
MUC5B WILD-TYPE | 20 | 24 | 18

'MUC5B MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.167 (Fisher's exact test), Q value = 1

Table S13. Gene #2: 'MUC5B MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 37 | 16 | 25
MUC5B MUTATED | 5 | 2 | 8
MUC5B WILD-TYPE | 32 | 14 | 17

'MUC5B MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.409 (Fisher's exact test), Q value = 1

Table S14. Gene #2: 'MUC5B MUTATION STATUS' versus Molecular Subtype #6: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 26 | 9 | 43
MUC5B MUTATED | 7 | 2 | 6
MUC5B WILD-TYPE | 19 | 7 | 37

'MUC5B MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.393 (Fisher's exact test), Q value = 1

Table S15. Gene #2: 'MUC5B MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 38 | 18 | 22
MUC5B MUTATED | 5 | 4 | 6
MUC5B WILD-TYPE | 33 | 14 | 16

'MUC5B MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.465 (Fisher's exact test), Q value = 1

Table S16. Gene #2: 'MUC5B MUTATION STATUS' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 41 | 10 | 27
MUC5B MUTATED | 6 | 2 | 7
MUC5B WILD-TYPE | 35 | 8 | 20

'CRIPAK MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0539 (Chi-square test), Q value = 1

Table S17. Gene #3: 'CRIPAK MUTATION STATUS' versus Molecular Subtype #1: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 31 | 23 | 15 | 10 | 9
CRIPAK MUTATED | 3 | 3 | 0 | 4 | 1
CRIPAK WILD-TYPE | 28 | 20 | 15 | 6 | 8

'CRIPAK MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.533 (Chi-square test), Q value = 1

Table S18. Gene #3: 'CRIPAK MUTATION STATUS' versus Molecular Subtype #2: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 17 | 11 | 21 | 18 | 11
CRIPAK MUTATED | 3 | 2 | 1 | 1 | 2
CRIPAK WILD-TYPE | 14 | 9 | 20 | 17 | 9

'CRIPAK MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.257 (Fisher's exact test), Q value = 1

Table S19. Gene #3: 'CRIPAK MUTATION STATUS' versus Molecular Subtype #3: 'MRNASEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 23 | 14 | 17 | 23
CRIPAK MUTATED | 5 | 0 | 2 | 2
CRIPAK WILD-TYPE | 18 | 14 | 15 | 21

'CRIPAK MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.162 (Fisher's exact test), Q value = 1

Table S20. Gene #3: 'CRIPAK MUTATION STATUS' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 22 | 32 | 23
CRIPAK MUTATED | 5 | 3 | 1
CRIPAK WILD-TYPE | 17 | 29 | 22

'CRIPAK MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.588 (Fisher's exact test), Q value = 1

Table S21. Gene #3: 'CRIPAK MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 37 | 16 | 25
CRIPAK MUTATED | 6 | 1 | 2
CRIPAK WILD-TYPE | 31 | 15 | 23

'CRIPAK MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.688 (Fisher's exact test), Q value = 1

Table S22. Gene #3: 'CRIPAK MUTATION STATUS' versus Molecular Subtype #6: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 26 | 9 | 43
CRIPAK MUTATED | 3 | 0 | 6
CRIPAK WILD-TYPE | 23 | 9 | 37

'CRIPAK MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.655 (Fisher's exact test), Q value = 1

Table S23. Gene #3: 'CRIPAK MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 38 | 18 | 22
CRIPAK MUTATED | 6 | 1 | 2
CRIPAK WILD-TYPE | 32 | 17 | 20

'CRIPAK MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.623 (Fisher's exact test), Q value = 1

Table S24. Gene #3: 'CRIPAK MUTATION STATUS' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 41 | 10 | 27
CRIPAK MUTATED | 6 | 0 | 3
CRIPAK WILD-TYPE | 35 | 10 | 24

'TP53 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.00857 (Chi-square test), Q value = 0.57

Table S25. Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #1: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 31 | 23 | 15 | 10 | 9
TP53 MUTATED | 5 | 0 | 4 | 5 | 1
TP53 WILD-TYPE | 26 | 23 | 11 | 5 | 8

Figure S5. Get High-res Image Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #1: 'CN_CNMF'

'TP53 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.444 (Chi-square test), Q value = 1

Table S26. Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #2: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 17 | 11 | 21 | 18 | 11
TP53 MUTATED | 3 | 3 | 5 | 1 | 1
TP53 WILD-TYPE | 14 | 8 | 16 | 17 | 10

'TP53 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.0122 (Fisher's exact test), Q value = 0.77

Table S27. Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #3: 'MRNASEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 23 | 14 | 17 | 23
TP53 MUTATED | 4 | 3 | 6 | 0
TP53 WILD-TYPE | 19 | 11 | 11 | 23

Figure S6. Get High-res Image Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #3: 'MRNASEQ_CNMF'

'TP53 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0784 (Fisher's exact test), Q value = 1

Table S28. Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 22 | 32 | 23
TP53 MUTATED | 5 | 2 | 6
TP53 WILD-TYPE | 17 | 30 | 17

'TP53 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.00968 (Fisher's exact test), Q value = 0.63

Table S29. Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 37 | 16 | 25
TP53 MUTATED | 9 | 4 | 0
TP53 WILD-TYPE | 28 | 12 | 25

Figure S7. Get High-res Image Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

'TP53 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.087 (Fisher's exact test), Q value = 1

Table S30. Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #6: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 26 | 9 | 43
TP53 MUTATED | 2 | 0 | 11
TP53 WILD-TYPE | 24 | 9 | 32

'TP53 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0321 (Fisher's exact test), Q value = 1

Table S31. Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 38 | 18 | 22
TP53 MUTATED | 9 | 4 | 0
TP53 WILD-TYPE | 29 | 14 | 22

Figure S8. Get High-res Image Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

'TP53 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.0377 (Fisher's exact test), Q value = 1

Table S32. Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 41 | 10 | 27
TP53 MUTATED | 11 | 0 | 2
TP53 WILD-TYPE | 30 | 10 | 25

Figure S9. Get High-res Image Gene #4: 'TP53 MUTATION STATUS' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'

'MEN1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.427 (Chi-square test), Q value = 1

Table S33. Gene #5: 'MEN1 MUTATION STATUS' versus Molecular Subtype #1: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 31 | 23 | 15 | 10 | 9
MEN1 MUTATED | 1 | 1 | 1 | 2 | 1
MEN1 WILD-TYPE | 30 | 22 | 14 | 8 | 8

'MEN1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.0201 (Chi-square test), Q value = 1

Table S34. Gene #5: 'MEN1 MUTATION STATUS' versus Molecular Subtype #2: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 17 | 11 | 21 | 18 | 11
MEN1 MUTATED | 0 | 3 | 4 | 0 | 0
MEN1 WILD-TYPE | 17 | 8 | 17 | 18 | 11

Figure S10. Get High-res Image Gene #5: 'MEN1 MUTATION STATUS' versus Molecular Subtype #2: 'METHLYATION_CNMF'

'MEN1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.352 (Fisher's exact test), Q value = 1

Table S35. Gene #5: 'MEN1 MUTATION STATUS' versus Molecular Subtype #3: 'MRNASEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 23 | 14 | 17 | 23
MEN1 MUTATED | 1 | 2 | 3 | 1
MEN1 WILD-TYPE | 22 | 12 | 14 | 22

'MEN1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.0698 (Fisher's exact test), Q value = 1

Table S36. Gene #5: 'MEN1 MUTATION STATUS' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 22 | 32 | 23
MEN1 MUTATED | 1 | 1 | 5
MEN1 WILD-TYPE | 21 | 31 | 18

'MEN1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.666 (Fisher's exact test), Q value = 1

Table S37. Gene #5: 'MEN1 MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 37 | 16 | 25
MEN1 MUTATED | 4 | 2 | 1
MEN1 WILD-TYPE | 33 | 14 | 24

'MEN1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.514 (Fisher's exact test), Q value = 1

Table S38. Gene #5: 'MEN1 MUTATION STATUS' versus Molecular Subtype #6: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 26 | 9 | 43
MEN1 MUTATED | 1 | 1 | 5
MEN1 WILD-TYPE | 25 | 8 | 38

'MEN1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.771 (Fisher's exact test), Q value = 1

Table S39. Gene #5: 'MEN1 MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 38 | 18 | 22
MEN1 MUTATED | 4 | 2 | 1
MEN1 WILD-TYPE | 34 | 16 | 21

'MEN1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.536 (Fisher's exact test), Q value = 1

Table S40. Gene #5: 'MEN1 MUTATION STATUS' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 41 | 10 | 27
MEN1 MUTATED | 5 | 1 | 1
MEN1 WILD-TYPE | 36 | 9 | 26

'PRKAR1A MUTATION STATUS' versus 'CN_CNMF'

P value = 0.958 (Chi-square test), Q value = 1

Table S41. Gene #6: 'PRKAR1A MUTATION STATUS' versus Molecular Subtype #1: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 31 | 23 | 15 | 10 | 9
PRKAR1A MUTATED | 2 | 1 | 1 | 1 | 1
PRKAR1A WILD-TYPE | 29 | 22 | 14 | 9 | 8

'PRKAR1A MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.702 (Chi-square test), Q value = 1

Table S42. Gene #6: 'PRKAR1A MUTATION STATUS' versus Molecular Subtype #2: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 17 | 11 | 21 | 18 | 11
PRKAR1A MUTATED | 1 | 1 | 1 | 1 | 2
PRKAR1A WILD-TYPE | 16 | 10 | 20 | 17 | 9

'PRKAR1A MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.188 (Fisher's exact test), Q value = 1

Table S43. Gene #6: 'PRKAR1A MUTATION STATUS' versus Molecular Subtype #3: 'MRNASEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 23 | 14 | 17 | 23
PRKAR1A MUTATED | 2 | 1 | 3 | 0
PRKAR1A WILD-TYPE | 21 | 13 | 14 | 23

'PRKAR1A MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.878 (Fisher's exact test), Q value = 1

Table S44. Gene #6: 'PRKAR1A MUTATION STATUS' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 22 | 32 | 23
PRKAR1A MUTATED | 1 | 3 | 2
PRKAR1A WILD-TYPE | 21 | 29 | 21

'PRKAR1A MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.855 (Fisher's exact test), Q value = 1

Table S45. Gene #6: 'PRKAR1A MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 37 | 16 | 25
PRKAR1A MUTATED | 4 | 1 | 1
PRKAR1A WILD-TYPE | 33 | 15 | 24

'PRKAR1A MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S46. Gene #6: 'PRKAR1A MUTATION STATUS' versus Molecular Subtype #6: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 26 | 9 | 43
PRKAR1A MUTATED | 2 | 0 | 4
PRKAR1A WILD-TYPE | 24 | 9 | 39

'PRKAR1A MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.3 (Fisher's exact test), Q value = 1

Table S47. Gene #6: 'PRKAR1A MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 38 | 18 | 22
PRKAR1A MUTATED | 4 | 2 | 0
PRKAR1A WILD-TYPE | 34 | 16 | 22

'PRKAR1A MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.854 (Fisher's exact test), Q value = 1

Table S48. Gene #6: 'PRKAR1A MUTATION STATUS' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 41 | 10 | 27
PRKAR1A MUTATED | 4 | 0 | 2
PRKAR1A WILD-TYPE | 37 | 10 | 25

'KRTAP4-5 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.538 (Chi-square test), Q value = 1

Table S49. Gene #7: 'KRTAP4-5 MUTATION STATUS' versus Molecular Subtype #1: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 31 | 23 | 15 | 10 | 9
KRTAP4-5 MUTATED | 1 | 2 | 0 | 0 | 1
KRTAP4-5 WILD-TYPE | 30 | 21 | 15 | 10 | 8

'KRTAP4-5 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.000785 (Chi-square test), Q value = 0.054

Table S50. Gene #7: 'KRTAP4-5 MUTATION STATUS' versus Molecular Subtype #2: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 17 | 11 | 21 | 18 | 11
KRTAP4-5 MUTATED | 0 | 3 | 0 | 0 | 0
KRTAP4-5 WILD-TYPE | 17 | 8 | 21 | 18 | 11

Figure S11. Get High-res Image Gene #7: 'KRTAP4-5 MUTATION STATUS' versus Molecular Subtype #2: 'METHLYATION_CNMF'

'KRTAP4-5 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 1 (Fisher's exact test), Q value = 1

Table S51. Gene #7: 'KRTAP4-5 MUTATION STATUS' versus Molecular Subtype #3: 'MRNASEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 23 | 14 | 17 | 23
KRTAP4-5 MUTATED | 1 | 0 | 1 | 1
KRTAP4-5 WILD-TYPE | 22 | 14 | 16 | 22

'KRTAP4-5 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S52. Gene #7: 'KRTAP4-5 MUTATION STATUS' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 22 | 32 | 23
KRTAP4-5 MUTATED | 1 | 1 | 1
KRTAP4-5 WILD-TYPE | 21 | 31 | 22

'KRTAP4-5 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.781 (Fisher's exact test), Q value = 1

Table S53. Gene #7: 'KRTAP4-5 MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 37 | 16 | 25
KRTAP4-5 MUTATED | 1 | 1 | 1
KRTAP4-5 WILD-TYPE | 36 | 15 | 24

'KRTAP4-5 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.213 (Fisher's exact test), Q value = 1

Table S54. Gene #7: 'KRTAP4-5 MUTATION STATUS' versus Molecular Subtype #6: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 26 | 9 | 43
KRTAP4-5 MUTATED | 0 | 1 | 2
KRTAP4-5 WILD-TYPE | 26 | 8 | 41

'KRTAP4-5 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.797 (Fisher's exact test), Q value = 1

Table S55. Gene #7: 'KRTAP4-5 MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 38 | 18 | 22
KRTAP4-5 MUTATED | 1 | 1 | 1
KRTAP4-5 WILD-TYPE | 37 | 17 | 21

'KRTAP4-5 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.234 (Fisher's exact test), Q value = 1

Table S56. Gene #7: 'KRTAP4-5 MUTATION STATUS' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 41 | 10 | 27
KRTAP4-5 MUTATED | 2 | 1 | 0
KRTAP4-5 WILD-TYPE | 39 | 9 | 27

'ATN1 MUTATION STATUS' versus 'CN_CNMF'

P value = 0.0602 (Chi-square test), Q value = 1

Table S57. Gene #8: 'ATN1 MUTATION STATUS' versus Molecular Subtype #1: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 31 | 23 | 15 | 10 | 9
ATN1 MUTATED | 0 | 2 | 0 | 2 | 0
ATN1 WILD-TYPE | 31 | 21 | 15 | 8 | 9

'ATN1 MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.657 (Chi-square test), Q value = 1

Table S58. Gene #8: 'ATN1 MUTATION STATUS' versus Molecular Subtype #2: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 17 | 11 | 21 | 18 | 11
ATN1 MUTATED | 1 | 1 | 0 | 1 | 0
ATN1 WILD-TYPE | 16 | 10 | 21 | 17 | 11

'ATN1 MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.877 (Fisher's exact test), Q value = 1

Table S59. Gene #8: 'ATN1 MUTATION STATUS' versus Molecular Subtype #3: 'MRNASEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 23 | 14 | 17 | 23
ATN1 MUTATED | 1 | 1 | 0 | 1
ATN1 WILD-TYPE | 22 | 13 | 17 | 22

'ATN1 MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S60. Gene #8: 'ATN1 MUTATION STATUS' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 22 | 32 | 23
ATN1 MUTATED | 1 | 1 | 1
ATN1 WILD-TYPE | 21 | 31 | 22

'ATN1 MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.781 (Fisher's exact test), Q value = 1

Table S61. Gene #8: 'ATN1 MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 37 | 16 | 25
ATN1 MUTATED | 1 | 1 | 1
ATN1 WILD-TYPE | 36 | 15 | 24

'ATN1 MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 0.691 (Fisher's exact test), Q value = 1

Table S62. Gene #8: 'ATN1 MUTATION STATUS' versus Molecular Subtype #6: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 26 | 9 | 43
ATN1 MUTATED | 2 | 0 | 1
ATN1 WILD-TYPE | 24 | 9 | 42

'ATN1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.797 (Fisher's exact test), Q value = 1

Table S63. Gene #8: 'ATN1 MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 38 | 18 | 22
ATN1 MUTATED | 1 | 1 | 1
ATN1 WILD-TYPE | 37 | 17 | 21

'ATN1 MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 0.709 (Fisher's exact test), Q value = 1

Table S64. Gene #8: 'ATN1 MUTATION STATUS' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 41 | 10 | 27
ATN1 MUTATED | 1 | 0 | 2
ATN1 WILD-TYPE | 40 | 10 | 25

'DMKN MUTATION STATUS' versus 'CN_CNMF'

P value = 0.693 (Chi-square test), Q value = 1

Table S65. Gene #9: 'DMKN MUTATION STATUS' versus Molecular Subtype #1: 'CN_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 31 | 23 | 15 | 10 | 9
DMKN MUTATED | 1 | 1 | 0 | 1 | 0
DMKN WILD-TYPE | 30 | 22 | 15 | 9 | 9

'DMKN MUTATION STATUS' versus 'METHLYATION_CNMF'

P value = 0.344 (Chi-square test), Q value = 1

Table S66. Gene #9: 'DMKN MUTATION STATUS' versus Molecular Subtype #2: 'METHLYATION_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5
--- | --- | --- | --- | --- | ---
ALL | 17 | 11 | 21 | 18 | 11
DMKN MUTATED | 0 | 1 | 2 | 0 | 0
DMKN WILD-TYPE | 17 | 10 | 19 | 18 | 11

'DMKN MUTATION STATUS' versus 'MRNASEQ_CNMF'

P value = 0.617 (Fisher's exact test), Q value = 1

Table S67. Gene #9: 'DMKN MUTATION STATUS' versus Molecular Subtype #3: 'MRNASEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4
--- | --- | --- | --- | ---
ALL | 23 | 14 | 17 | 23
DMKN MUTATED | 1 | 1 | 1 | 0
DMKN WILD-TYPE | 22 | 13 | 16 | 23

'DMKN MUTATION STATUS' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.262 (Fisher's exact test), Q value = 1

Table S68. Gene #9: 'DMKN MUTATION STATUS' versus Molecular Subtype #4: 'MRNASEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 22 | 32 | 23
DMKN MUTATED | 1 | 0 | 2
DMKN WILD-TYPE | 21 | 32 | 21

'DMKN MUTATION STATUS' versus 'MIRSEQ_CNMF'

P value = 0.00736 (Fisher's exact test), Q value = 0.5

Table S69. Gene #9: 'DMKN MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 37 | 16 | 25
DMKN MUTATED | 0 | 3 | 0
DMKN WILD-TYPE | 37 | 13 | 25

Figure S12. Get High-res Image Gene #9: 'DMKN MUTATION STATUS' versus Molecular Subtype #5: 'MIRSEQ_CNMF'

'DMKN MUTATION STATUS' versus 'MIRSEQ_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S70. Gene #9: 'DMKN MUTATION STATUS' versus Molecular Subtype #6: 'MIRSEQ_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 26 | 9 | 43
DMKN MUTATED | 1 | 0 | 2
DMKN WILD-TYPE | 25 | 9 | 41

'DMKN MUTATION STATUS' versus 'MIRSEQ_MATURE_CNMF'

P value = 0.0107 (Fisher's exact test), Q value = 0.69

Table S71. Gene #9: 'DMKN MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 38 | 18 | 22
DMKN MUTATED | 0 | 3 | 0
DMKN WILD-TYPE | 38 | 15 | 22

Figure S13. Get High-res Image Gene #9: 'DMKN MUTATION STATUS' versus Molecular Subtype #7: 'MIRSEQ_MATURE_CNMF'

'DMKN MUTATION STATUS' versus 'MIRSEQ_MATURE_CHIERARCHICAL'

P value = 1 (Fisher's exact test), Q value = 1

Table S72. Gene #9: 'DMKN MUTATION STATUS' versus Molecular Subtype #8: 'MIRSEQ_MATURE_CHIERARCHICAL'

nPatients | CLUS_1 | CLUS_2 | CLUS_3
--- | --- | --- | ---
ALL | 41 | 10 | 27
DMKN MUTATED | 2 | 0 | 1
DMKN WILD-TYPE | 39 | 10 | 26

Methods & Data
Input

- Mutation data file = transformed.cor.cli.txt

- Molecular subtypes file = ACC-TP.transferedmergedcluster.txt

- Number of patients = 90

- Number of significantly mutated genes = 9

- Number of Molecular subtypes = 8

- Exclude genes that fewer than K tumors have mutations, K = 3

Chi-square test

For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

- Analysis Results (MD5 checksum)

- Auxiliary Data (MD5 checksum)

- MAGE-TAB File (MD5 checksum)

References
[1] Greenwood and Nikulin, A guide to chi-squared testing, Wiley, New York. ISBN 047155779X (1996)
[2] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[3] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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