Correlation between copy number variation genes (focal events) and selected clinical features
Bladder Urothelial Carcinoma (Primary solid tumor)
15 January 2014
|
analyses__2014_01_15
Maintainer Information
Citation Information
Maintained by TCGA GDAC Team
(Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2014):
Correlation between copy number variation genes (focal events) and selected clinical features.
Broad Institute of MIT and Harvard.
doi:10.7908/C16W98GW
Overview
Introduction
This pipeline computes the correlation between significant copy number variation (cnv focal) genes and selected clinical features.
Summary
Testing the association between copy number variation 62 focal events and 11 clinical features across 183 patients, no significant finding detected with Q value < 0.25.
-
No focal cnvs related to clinical features.
Results
Overview of the results
Table 1. Get Full Table Overview of the association between significant copy number variation of 62 focal events and 11 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, no significant finding detected.
|
Clinical Features |
Time to Death |
AGE |
NEOPLASM DISEASESTAGE |
PATHOLOGY T STAGE |
PATHOLOGY N STAGE |
PATHOLOGY M STAGE |
GENDER |
KARNOFSKY PERFORMANCE SCORE |
NUMBERPACKYEARSSMOKED |
NUMBER OF LYMPH NODES |
GLEASON SCORE |
||
| nCNV (%) | nWild-Type | logrank test | t-test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | t-test | t-test | t-test | t-test | |
| amp 1p34 2 | 56 (31%) | 127 |
0.647 (1.00) |
0.106 (1.00) |
0.297 (1.00) |
0.686 (1.00) |
0.275 (1.00) |
0.825 (1.00) |
0.716 (1.00) |
0.803 (1.00) |
0.144 (1.00) |
0.47 (1.00) |
0.55 (1.00) |
| amp 1q21 3 | 93 (51%) | 90 |
0.188 (1.00) |
0.271 (1.00) |
0.00623 (1.00) |
0.774 (1.00) |
0.0103 (1.00) |
0.355 (1.00) |
0.496 (1.00) |
0.0703 (1.00) |
0.31 (1.00) |
0.0869 (1.00) |
0.49 (1.00) |
| amp 1q23 3 | 98 (54%) | 85 |
0.885 (1.00) |
0.0493 (1.00) |
0.0937 (1.00) |
0.285 (1.00) |
0.0276 (1.00) |
0.0653 (1.00) |
0.235 (1.00) |
0.261 (1.00) |
0.536 (1.00) |
0.223 (1.00) |
0.178 (1.00) |
| amp 3p25 2 | 87 (48%) | 96 |
0.595 (1.00) |
0.251 (1.00) |
0.348 (1.00) |
0.131 (1.00) |
0.0476 (1.00) |
0.922 (1.00) |
0.0601 (1.00) |
0.0193 (1.00) |
0.375 (1.00) |
0.175 (1.00) |
0.43 (1.00) |
| amp 3q26 32 | 98 (54%) | 85 |
0.284 (1.00) |
0.926 (1.00) |
0.9 (1.00) |
0.849 (1.00) |
0.142 (1.00) |
0.921 (1.00) |
1 (1.00) |
0.158 (1.00) |
0.693 (1.00) |
0.56 (1.00) |
0.525 (1.00) |
| amp 4p16 3 | 41 (22%) | 142 |
0.0562 (1.00) |
0.637 (1.00) |
0.101 (1.00) |
0.126 (1.00) |
0.00862 (1.00) |
0.0363 (1.00) |
0.417 (1.00) |
0.382 (1.00) |
0.191 (1.00) |
0.61 (1.00) |
0.188 (1.00) |
| amp 4q13 3 | 31 (17%) | 152 |
0.698 (1.00) |
0.283 (1.00) |
0.958 (1.00) |
0.311 (1.00) |
1 (1.00) |
0.486 (1.00) |
0.0236 (1.00) |
0.278 (1.00) |
0.891 (1.00) |
0.455 (1.00) |
0.738 (1.00) |
| amp 5p15 33 | 89 (49%) | 94 |
0.779 (1.00) |
0.446 (1.00) |
0.692 (1.00) |
0.911 (1.00) |
0.591 (1.00) |
0.151 (1.00) |
0.496 (1.00) |
0.366 (1.00) |
0.212 (1.00) |
0.0824 (1.00) |
0.059 (1.00) |
| amp 6p22 3 | 72 (39%) | 111 |
0.37 (1.00) |
0.535 (1.00) |
0.0627 (1.00) |
0.0394 (1.00) |
0.133 (1.00) |
0.875 (1.00) |
1 (1.00) |
0.846 (1.00) |
0.843 (1.00) |
0.0359 (1.00) |
0.4 (1.00) |
| amp 6q21 | 17 (9%) | 166 |
0.377 (1.00) |
0.901 (1.00) |
0.721 (1.00) |
0.815 (1.00) |
0.496 (1.00) |
0.389 (1.00) |
0.568 (1.00) |
0.567 (1.00) |
0.19 (1.00) |
0.942 (1.00) |
0.925 (1.00) |
| amp 7p21 1 | 94 (51%) | 89 |
0.546 (1.00) |
0.184 (1.00) |
0.184 (1.00) |
0.472 (1.00) |
0.103 (1.00) |
0.269 (1.00) |
0.734 (1.00) |
0.252 (1.00) |
0.511 (1.00) |
0.562 (1.00) |
0.0229 (1.00) |
| amp 7p11 2 | 94 (51%) | 89 |
0.566 (1.00) |
0.0293 (1.00) |
0.396 (1.00) |
1 (1.00) |
0.00296 (1.00) |
0.626 (1.00) |
0.496 (1.00) |
0.471 (1.00) |
0.839 (1.00) |
0.128 (1.00) |
0.0641 (1.00) |
| amp 8p11 23 | 58 (32%) | 125 |
0.857 (1.00) |
0.667 (1.00) |
0.717 (1.00) |
0.974 (1.00) |
0.3 (1.00) |
0.524 (1.00) |
0.714 (1.00) |
0.565 (1.00) |
0.613 (1.00) |
0.577 (1.00) |
0.0406 (1.00) |
| amp 8p11 21 | 59 (32%) | 124 |
0.168 (1.00) |
0.882 (1.00) |
0.459 (1.00) |
0.507 (1.00) |
0.594 (1.00) |
0.247 (1.00) |
0.203 (1.00) |
0.415 (1.00) |
0.589 (1.00) |
0.616 (1.00) |
0.229 (1.00) |
| amp 8q22 3 | 116 (63%) | 67 |
0.88 (1.00) |
0.4 (1.00) |
0.714 (1.00) |
0.904 (1.00) |
0.321 (1.00) |
0.732 (1.00) |
0.159 (1.00) |
0.795 (1.00) |
0.171 (1.00) |
0.155 (1.00) |
0.539 (1.00) |
| amp 8q24 21 | 113 (62%) | 70 |
0.773 (1.00) |
0.833 (1.00) |
0.441 (1.00) |
0.883 (1.00) |
0.309 (1.00) |
0.804 (1.00) |
0.16 (1.00) |
0.674 (1.00) |
0.576 (1.00) |
0.17 (1.00) |
0.96 (1.00) |
| amp 9p24 1 | 38 (21%) | 145 |
0.354 (1.00) |
0.373 (1.00) |
0.936 (1.00) |
0.605 (1.00) |
0.58 (1.00) |
0.237 (1.00) |
0.401 (1.00) |
0.302 (1.00) |
0.203 (1.00) |
0.991 (1.00) |
0.742 (1.00) |
| amp 10p15 1 | 77 (42%) | 106 |
0.558 (1.00) |
0.0432 (1.00) |
0.539 (1.00) |
0.806 (1.00) |
0.178 (1.00) |
0.877 (1.00) |
0.864 (1.00) |
0.761 (1.00) |
0.628 (1.00) |
0.755 (1.00) |
0.382 (1.00) |
| amp 11q13 3 | 71 (39%) | 112 |
0.833 (1.00) |
0.163 (1.00) |
0.748 (1.00) |
0.528 (1.00) |
0.371 (1.00) |
0.308 (1.00) |
1 (1.00) |
0.616 (1.00) |
0.978 (1.00) |
0.737 (1.00) |
0.118 (1.00) |
| amp 11q22 2 | 35 (19%) | 148 |
0.166 (1.00) |
0.155 (1.00) |
0.866 (1.00) |
0.624 (1.00) |
0.637 (1.00) |
0.503 (1.00) |
1 (1.00) |
0.921 (1.00) |
0.652 (1.00) |
0.721 (1.00) |
0.0638 (1.00) |
| amp 12q15 | 56 (31%) | 127 |
0.345 (1.00) |
0.542 (1.00) |
0.776 (1.00) |
0.51 (1.00) |
0.415 (1.00) |
0.705 (1.00) |
0.716 (1.00) |
0.783 (1.00) |
0.249 (1.00) |
0.315 (1.00) |
0.968 (1.00) |
| amp 13q22 1 | 58 (32%) | 125 |
0.559 (1.00) |
0.0243 (1.00) |
0.565 (1.00) |
0.826 (1.00) |
0.571 (1.00) |
0.46 (1.00) |
0.714 (1.00) |
0.331 (1.00) |
0.793 (1.00) |
0.922 (1.00) |
0.308 (1.00) |
| amp 16p12 1 | 46 (25%) | 137 |
0.408 (1.00) |
0.229 (1.00) |
0.161 (1.00) |
0.0317 (1.00) |
0.0761 (1.00) |
0.206 (1.00) |
0.847 (1.00) |
0.223 (1.00) |
0.845 (1.00) |
0.936 (1.00) |
0.0662 (1.00) |
| amp 17q11 2 | 83 (45%) | 100 |
0.359 (1.00) |
0.226 (1.00) |
0.0737 (1.00) |
0.381 (1.00) |
0.0522 (1.00) |
0.191 (1.00) |
1 (1.00) |
0.00663 (1.00) |
0.875 (1.00) |
0.548 (1.00) |
0.5 (1.00) |
| amp 17q12 | 76 (42%) | 107 |
0.115 (1.00) |
0.262 (1.00) |
0.389 (1.00) |
0.0145 (1.00) |
0.271 (1.00) |
0.361 (1.00) |
0.863 (1.00) |
0.0503 (1.00) |
0.177 (1.00) |
0.965 (1.00) |
0.792 (1.00) |
| amp 19q12 | 76 (42%) | 107 |
0.604 (1.00) |
0.758 (1.00) |
0.114 (1.00) |
0.355 (1.00) |
0.186 (1.00) |
0.917 (1.00) |
1 (1.00) |
0.271 (1.00) |
0.433 (1.00) |
0.141 (1.00) |
0.55 (1.00) |
| amp 20q11 21 | 120 (66%) | 63 |
0.664 (1.00) |
0.375 (1.00) |
0.368 (1.00) |
0.567 (1.00) |
0.252 (1.00) |
0.799 (1.00) |
1 (1.00) |
0.185 (1.00) |
0.372 (1.00) |
0.277 (1.00) |
0.693 (1.00) |
| amp 22q11 23 | 42 (23%) | 141 |
0.488 (1.00) |
0.242 (1.00) |
0.733 (1.00) |
0.904 (1.00) |
0.706 (1.00) |
0.943 (1.00) |
0.163 (1.00) |
0.242 (1.00) |
0.247 (1.00) |
0.905 (1.00) |
0.396 (1.00) |
| del 1p36 11 | 34 (19%) | 149 |
0.138 (1.00) |
0.244 (1.00) |
0.724 (1.00) |
0.52 (1.00) |
0.00157 (1.00) |
0.876 (1.00) |
1 (1.00) |
0.829 (1.00) |
0.686 (1.00) |
0.185 (1.00) |
0.0433 (1.00) |
| del 1q32 1 | 34 (19%) | 149 |
0.791 (1.00) |
0.158 (1.00) |
0.496 (1.00) |
0.559 (1.00) |
0.345 (1.00) |
0.937 (1.00) |
0.0503 (1.00) |
0.591 (1.00) |
0.000492 (0.336) |
0.359 (1.00) |
0.903 (1.00) |
| del 2q22 1 | 55 (30%) | 128 |
0.833 (1.00) |
0.867 (1.00) |
0.465 (1.00) |
0.842 (1.00) |
0.359 (1.00) |
0.631 (1.00) |
0.267 (1.00) |
0.467 (1.00) |
0.264 (1.00) |
0.769 (1.00) |
0.461 (1.00) |
| del 2q37 1 | 90 (49%) | 93 |
0.31 (1.00) |
0.5 (1.00) |
0.162 (1.00) |
0.811 (1.00) |
0.1 (1.00) |
0.512 (1.00) |
0.0623 (1.00) |
0.174 (1.00) |
0.699 (1.00) |
0.806 (1.00) |
0.485 (1.00) |
| del 3p21 31 | 55 (30%) | 128 |
0.751 (1.00) |
0.685 (1.00) |
0.989 (1.00) |
0.972 (1.00) |
0.74 (1.00) |
0.316 (1.00) |
0.267 (1.00) |
0.635 (1.00) |
0.771 (1.00) |
0.16 (1.00) |
0.241 (1.00) |
| del 3p14 2 | 54 (30%) | 129 |
0.599 (1.00) |
0.35 (1.00) |
0.968 (1.00) |
0.842 (1.00) |
0.121 (1.00) |
0.208 (1.00) |
0.262 (1.00) |
0.454 (1.00) |
0.801 (1.00) |
0.0408 (1.00) |
0.391 (1.00) |
| del 3p13 | 49 (27%) | 134 |
0.962 (1.00) |
0.0987 (1.00) |
0.964 (1.00) |
0.759 (1.00) |
0.398 (1.00) |
0.131 (1.00) |
0.565 (1.00) |
0.103 (1.00) |
0.807 (1.00) |
0.11 (1.00) |
0.391 (1.00) |
| del 4q22 1 | 70 (38%) | 113 |
0.664 (1.00) |
0.2 (1.00) |
0.606 (1.00) |
0.123 (1.00) |
0.58 (1.00) |
0.705 (1.00) |
0.293 (1.00) |
0.476 (1.00) |
0.982 (1.00) |
0.2 (1.00) |
0.045 (1.00) |
| del 4q34 2 | 77 (42%) | 106 |
0.98 (1.00) |
0.391 (1.00) |
0.621 (1.00) |
0.269 (1.00) |
0.419 (1.00) |
0.48 (1.00) |
1 (1.00) |
0.187 (1.00) |
0.569 (1.00) |
0.473 (1.00) |
0.121 (1.00) |
| del 5q11 2 | 92 (50%) | 91 |
0.881 (1.00) |
0.0167 (1.00) |
0.127 (1.00) |
0.955 (1.00) |
0.0293 (1.00) |
0.158 (1.00) |
0.499 (1.00) |
0.072 (1.00) |
0.983 (1.00) |
0.197 (1.00) |
0.69 (1.00) |
| del 6p25 3 | 50 (27%) | 133 |
0.921 (1.00) |
0.667 (1.00) |
0.124 (1.00) |
0.00972 (1.00) |
0.0152 (1.00) |
0.77 (1.00) |
0.251 (1.00) |
0.0433 (1.00) |
0.394 (1.00) |
0.0554 (1.00) |
0.399 (1.00) |
| del 6q21 | 83 (45%) | 100 |
0.75 (1.00) |
0.108 (1.00) |
0.0063 (1.00) |
0.64 (1.00) |
0.0155 (1.00) |
0.191 (1.00) |
0.497 (1.00) |
0.322 (1.00) |
0.917 (1.00) |
0.00317 (1.00) |
0.99 (1.00) |
| del 6q27 | 82 (45%) | 101 |
0.704 (1.00) |
0.291 (1.00) |
0.0276 (1.00) |
0.79 (1.00) |
0.021 (1.00) |
0.159 (1.00) |
0.732 (1.00) |
0.177 (1.00) |
0.43 (1.00) |
0.00576 (1.00) |
0.309 (1.00) |
| del 7q36 3 | 26 (14%) | 157 |
0.498 (1.00) |
0.691 (1.00) |
0.633 (1.00) |
0.353 (1.00) |
0.403 (1.00) |
0.483 (1.00) |
0.626 (1.00) |
0.36 (1.00) |
0.384 (1.00) |
0.622 (1.00) |
0.502 (1.00) |
| del 8p23 3 | 101 (55%) | 82 |
0.424 (1.00) |
0.179 (1.00) |
0.115 (1.00) |
0.542 (1.00) |
0.37 (1.00) |
0.0189 (1.00) |
0.304 (1.00) |
0.175 (1.00) |
0.898 (1.00) |
0.334 (1.00) |
0.631 (1.00) |
| del 8p11 21 | 41 (22%) | 142 |
0.191 (1.00) |
0.207 (1.00) |
0.0012 (0.82) |
0.0173 (1.00) |
0.336 (1.00) |
0.15 (1.00) |
0.839 (1.00) |
0.222 (1.00) |
0.509 (1.00) |
0.833 (1.00) |
0.577 (1.00) |
| del 9p23 | 80 (44%) | 103 |
0.433 (1.00) |
0.846 (1.00) |
0.982 (1.00) |
1 (1.00) |
1 (1.00) |
0.809 (1.00) |
1 (1.00) |
0.776 (1.00) |
0.454 (1.00) |
0.608 (1.00) |
0.433 (1.00) |
| del 9p21 3 | 107 (58%) | 76 |
0.821 (1.00) |
0.178 (1.00) |
0.878 (1.00) |
0.364 (1.00) |
0.462 (1.00) |
0.84 (1.00) |
1 (1.00) |
0.747 (1.00) |
0.258 (1.00) |
0.63 (1.00) |
0.396 (1.00) |
| del 10q23 31 | 72 (39%) | 111 |
0.628 (1.00) |
0.0157 (1.00) |
0.201 (1.00) |
0.722 (1.00) |
0.14 (1.00) |
0.47 (1.00) |
1 (1.00) |
0.0119 (1.00) |
0.761 (1.00) |
0.23 (1.00) |
0.4 (1.00) |
| del 11p15 5 | 87 (48%) | 96 |
0.267 (1.00) |
0.0716 (1.00) |
0.00497 (1.00) |
0.81 (1.00) |
0.00728 (1.00) |
0.381 (1.00) |
0.609 (1.00) |
0.242 (1.00) |
0.493 (1.00) |
0.0606 (1.00) |
0.556 (1.00) |
| del 11q25 | 62 (34%) | 121 |
0.837 (1.00) |
0.949 (1.00) |
0.753 (1.00) |
0.374 (1.00) |
0.442 (1.00) |
0.183 (1.00) |
1 (1.00) |
0.363 (1.00) |
0.708 (1.00) |
0.151 (1.00) |
0.965 (1.00) |
| del 13q14 2 | 72 (39%) | 111 |
0.18 (1.00) |
0.0289 (1.00) |
0.0732 (1.00) |
0.497 (1.00) |
0.125 (1.00) |
0.773 (1.00) |
0.731 (1.00) |
0.34 (1.00) |
0.836 (1.00) |
0.448 (1.00) |
0.526 (1.00) |
| del 14q12 | 54 (30%) | 129 |
0.574 (1.00) |
0.0909 (1.00) |
0.0262 (1.00) |
0.776 (1.00) |
0.0117 (1.00) |
0.904 (1.00) |
0.197 (1.00) |
0.195 (1.00) |
0.263 (1.00) |
0.155 (1.00) |
0.71 (1.00) |
| del 14q24 1 | 56 (31%) | 127 |
0.661 (1.00) |
0.547 (1.00) |
0.195 (1.00) |
0.824 (1.00) |
0.0191 (1.00) |
0.636 (1.00) |
0.144 (1.00) |
0.408 (1.00) |
0.128 (1.00) |
0.423 (1.00) |
0.659 (1.00) |
| del 15q13 1 | 71 (39%) | 112 |
0.4 (1.00) |
0.221 (1.00) |
0.399 (1.00) |
0.406 (1.00) |
0.213 (1.00) |
0.0312 (1.00) |
1 (1.00) |
0.192 (1.00) |
0.158 (1.00) |
0.658 (1.00) |
0.792 (1.00) |
| del 16p13 3 | 71 (39%) | 112 |
0.825 (1.00) |
0.216 (1.00) |
0.147 (1.00) |
0.046 (1.00) |
0.497 (1.00) |
0.427 (1.00) |
0.728 (1.00) |
0.479 (1.00) |
0.659 (1.00) |
0.638 (1.00) |
0.601 (1.00) |
| del 16q23 1 | 50 (27%) | 133 |
0.809 (1.00) |
0.451 (1.00) |
0.353 (1.00) |
0.809 (1.00) |
0.105 (1.00) |
0.623 (1.00) |
0.187 (1.00) |
0.0121 (1.00) |
0.864 (1.00) |
0.103 (1.00) |
0.557 (1.00) |
| del 17p12 | 94 (51%) | 89 |
0.812 (1.00) |
0.167 (1.00) |
0.0136 (1.00) |
0.57 (1.00) |
0.162 (1.00) |
1 (1.00) |
0.612 (1.00) |
0.431 (1.00) |
0.837 (1.00) |
0.48 (1.00) |
0.69 (1.00) |
| del 18q23 | 71 (39%) | 112 |
0.0484 (1.00) |
0.148 (1.00) |
0.908 (1.00) |
0.446 (1.00) |
0.75 (1.00) |
0.37 (1.00) |
0.728 (1.00) |
0.217 (1.00) |
0.227 (1.00) |
0.763 (1.00) |
0.551 (1.00) |
| del 19p13 3 | 68 (37%) | 115 |
0.611 (1.00) |
0.937 (1.00) |
0.0188 (1.00) |
0.0525 (1.00) |
0.0298 (1.00) |
0.00872 (1.00) |
0.597 (1.00) |
0.194 (1.00) |
0.432 (1.00) |
0.55 (1.00) |
0.66 (1.00) |
| del 22q13 31 | 77 (42%) | 106 |
0.949 (1.00) |
0.32 (1.00) |
0.221 (1.00) |
0.559 (1.00) |
0.289 (1.00) |
0.0043 (1.00) |
0.864 (1.00) |
0.0304 (1.00) |
0.966 (1.00) |
0.429 (1.00) |
0.685 (1.00) |
| del xp11 3 | 41 (22%) | 142 |
0.763 (1.00) |
0.103 (1.00) |
0.969 (1.00) |
0.651 (1.00) |
0.912 (1.00) |
0.739 (1.00) |
0.417 (1.00) |
0.74 (1.00) |
0.179 (1.00) |
0.995 (1.00) |
0.474 (1.00) |
| del xq21 33 | 34 (19%) | 149 |
0.927 (1.00) |
0.759 (1.00) |
0.882 (1.00) |
0.42 (1.00) |
0.847 (1.00) |
0.572 (1.00) |
0.829 (1.00) |
0.741 (1.00) |
0.663 (1.00) |
0.799 (1.00) |
0.429 (1.00) |
| del xq23 | 34 (19%) | 149 |
0.637 (1.00) |
0.902 (1.00) |
0.979 (1.00) |
0.961 (1.00) |
0.504 (1.00) |
0.458 (1.00) |
0.829 (1.00) |
0.912 (1.00) |
0.836 (1.00) |
0.999 (1.00) |
0.429 (1.00) |
Methods & Data
Input
-
Copy number data file = transformed.cor.cli.txt
-
Clinical data file = BLCA-TP.merged_data.txt
-
Number of patients = 183
-
Number of significantly focal cnvs = 62
-
Number of selected clinical features = 11
-
Exclude genes that fewer than K tumors have mutations, K = 3
Survival analysis
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
Student's t-test analysis
For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R
Fisher's exact test
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
Q value calculation
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
Download Results
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.
References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)
[3] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[4] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
Copyright © 2014
Broad Institute TCGA GDAC as part of the TCGA Research Network.
All rights reserved.