Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.064 0.24 -9999.0 0.0 -0.634 27.0 27.0 IHH -0.063 0.179 -9999.0 0.0 -0.484 32.0 32.0 SHH Np/Cholesterol/GAS1 -0.178 0.203 -9999.0 0.0 -0.354 119.0 119.0 LRPAP1 0.012 0.032 -9999.0 0.0 -0.462 1.0 1.0 dorsoventral neural tube patterning 0.177 0.201 0.351 119.0 -9999.0 0.0 119.0 SMO/beta Arrestin2 -0.054 0.171 -9999.0 0.0 -0.464 23.0 23.0 SMO -0.065 0.179 -9999.0 0.0 -0.496 23.0 23.0 AKT1 -0.007 0.082 -9999.0 0.0 -0.277 4.0 4.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.041 0.172 -9999.0 0.0 -0.574 21.0 21.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.064 0.177 -9999.0 0.0 -0.488 23.0 23.0 STIL -0.159 0.208 -9999.0 0.0 -0.46 49.0 49.0 DHH N/PTCH2 -0.024 0.133 -9999.0 0.0 -0.415 23.0 23.0 DHH N/PTCH1 -0.039 0.152 -9999.0 0.0 -0.409 20.0 20.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.013 0.122 -9999.0 0.0 -0.574 10.0 10.0 PTHLH -0.116 0.364 -9999.0 0.0 -1.031 27.0 27.0 determination of left/right symmetry -0.064 0.177 -9999.0 0.0 -0.488 23.0 23.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.113 0.358 -9999.0 0.0 -1.014 27.0 27.0 IHH N/Hhip -0.136 0.229 -9999.0 0.0 -0.478 63.0 63.0 DHH N/Hhip -0.104 0.201 -9999.0 0.0 -0.422 62.0 62.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.064 0.177 -9999.0 0.0 -0.488 23.0 23.0 pancreas development -0.129 0.249 -9999.0 0.0 -0.569 54.0 54.0 HHAT 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.125 0.25 -9999.0 0.0 -0.572 53.0 53.0 somite specification -0.064 0.177 -9999.0 0.0 -0.488 23.0 23.0 SHH Np/Cholesterol/PTCH1 -0.127 0.19 -9999.0 0.0 -0.438 36.0 36.0 SHH Np/Cholesterol/PTCH2 -0.119 0.179 -9999.0 0.0 -0.33 90.0 90.0 SHH Np/Cholesterol/Megalin -0.151 0.197 -9999.0 0.0 -0.374 82.0 82.0 SHH -0.14 0.209 -9999.0 0.0 -0.414 82.0 82.0 catabolic process -0.036 0.152 -9999.0 0.0 -0.364 31.0 31.0 SMO/Vitamin D3 -0.122 0.203 -9999.0 0.0 -0.447 39.0 39.0 SHH Np/Cholesterol/Hhip -0.181 0.219 -9999.0 0.0 -0.381 111.0 111.0 LRP2 -0.081 0.189 -9999.0 0.0 -0.462 44.0 44.0 receptor-mediated endocytosis -0.155 0.205 -9999.0 0.0 -0.446 53.0 53.0 SHH Np/Cholesterol/BOC -0.131 0.192 -9999.0 0.0 -0.346 93.0 93.0 SHH Np/Cholesterol/CDO -0.146 0.188 -9999.0 0.0 -0.336 105.0 105.0 mesenchymal cell differentiation 0.179 0.218 0.378 111.0 -9999.0 0.0 111.0 mol:Vitamin D3 -0.125 0.192 -9999.0 0.0 -0.439 36.0 36.0 IHH N/PTCH2 -0.051 0.148 -9999.0 0.0 -0.406 26.0 26.0 CDON -0.067 0.204 -9999.0 0.0 -0.574 31.0 31.0 IHH N/PTCH1 -0.036 0.154 -9999.0 0.0 -0.368 31.0 31.0 Megalin/LRPAP1 -0.048 0.136 -9999.0 0.0 -0.319 45.0 45.0 PTCH2 -0.02 0.138 -9999.0 0.0 -0.574 13.0 13.0 SHH Np/Cholesterol -0.115 0.157 -9999.0 0.0 -0.321 82.0 82.0 PTCH1 -0.036 0.153 -9999.0 0.0 -0.366 31.0 31.0 HHIP -0.129 0.25 -9999.0 0.0 -0.57 54.0 54.0