Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.011 0.098 0.321 16.0 -0.206 5.0 21.0 KIRREL -0.007 0.122 -9999.0 0.0 -0.439 16.0 16.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.011 0.098 0.207 5.0 -0.322 16.0 21.0 PLCG1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.038 0.089 0.264 1.0 -0.238 16.0 17.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.006 0.067 -9999.0 0.0 -0.229 13.0 13.0 FYN 0.003 0.101 0.288 10.0 -0.231 17.0 27.0 mol:Ca2+ 0.036 0.085 0.255 1.0 -0.237 14.0 15.0 mol:DAG 0.037 0.086 0.26 1.0 -0.237 14.0 15.0 NPHS2 0.013 0.066 0.271 11.0 -9999.0 0.0 11.0 mol:IP3 0.037 0.086 0.26 1.0 -0.237 14.0 15.0 regulation of endocytosis 0.024 0.077 -9999.0 0.0 -0.216 16.0 16.0 Nephrin/NEPH1/podocin/Cholesterol 0.026 0.084 0.246 1.0 -0.235 16.0 17.0 establishment of cell polarity 0.011 0.098 0.206 5.0 -0.321 16.0 21.0 Nephrin/NEPH1/podocin/NCK1-2 0.048 0.087 0.267 1.0 -0.219 15.0 16.0 Nephrin/NEPH1/beta Arrestin2 0.026 0.078 -9999.0 0.0 -0.218 16.0 16.0 NPHS1 0.007 0.051 0.278 5.0 -9999.0 0.0 5.0 Nephrin/NEPH1/podocin 0.025 0.085 -9999.0 0.0 -0.232 17.0 17.0 TJP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.038 0.086 0.264 1.0 -0.238 14.0 15.0 CD2AP 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.038 0.09 0.264 1.0 -0.238 16.0 17.0 GRB2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.006 0.098 0.297 10.0 -0.216 16.0 26.0 cytoskeleton organization -0.007 0.076 0.196 4.0 -0.253 15.0 19.0 Nephrin/NEPH1 0.013 0.07 0.17 5.0 -0.221 16.0 21.0 Nephrin/NEPH1/ZO-1 0.024 0.085 -9999.0 0.0 -0.256 16.0 16.0