Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.018 0.205 -9999.0 0.0 -0.546 25.0 25.0 IHH 0.047 0.115 0.292 20.0 -0.452 4.0 24.0 SHH Np/Cholesterol/GAS1 -0.111 0.147 -9999.0 0.0 -0.262 101.0 101.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.11 0.146 0.26 101.0 -9999.0 0.0 101.0 SMO/beta Arrestin2 -0.033 0.163 -9999.0 0.0 -0.413 21.0 21.0 SMO -0.045 0.165 -9999.0 0.0 -0.423 23.0 23.0 AKT1 -0.016 0.131 -9999.0 0.0 -0.5 9.0 9.0 ARRB2 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.014 0.128 -9999.0 0.0 -0.43 19.0 19.0 ADRBK1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.043 0.164 -9999.0 0.0 -0.416 23.0 23.0 STIL -0.064 0.145 0.249 1.0 -0.303 29.0 30.0 DHH N/PTCH2 0.002 0.104 -9999.0 0.0 -0.308 22.0 22.0 DHH N/PTCH1 0.0 0.123 -9999.0 0.0 -0.268 31.0 31.0 PIK3CA 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.001 0.095 -9999.0 0.0 -0.43 10.0 10.0 PTHLH -0.056 0.305 -9999.0 0.0 -0.84 26.0 26.0 determination of left/right symmetry -0.043 0.164 -9999.0 0.0 -0.416 23.0 23.0 PIK3R1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.055 0.302 -9999.0 0.0 -0.83 26.0 26.0 IHH N/Hhip -0.038 0.175 0.2 14.0 -0.344 50.0 64.0 DHH N/Hhip -0.053 0.155 0.197 1.0 -0.317 55.0 56.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.043 0.164 -9999.0 0.0 -0.416 23.0 23.0 pancreas development -0.078 0.187 0.269 1.0 -0.429 48.0 49.0 HHAT 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.034 0.013 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.052 0.171 0.269 1.0 -0.43 37.0 38.0 somite specification -0.043 0.164 -9999.0 0.0 -0.416 23.0 23.0 SHH Np/Cholesterol/PTCH1 -0.076 0.144 -9999.0 0.0 -0.313 32.0 32.0 SHH Np/Cholesterol/PTCH2 -0.081 0.134 -9999.0 0.0 -0.249 83.0 83.0 SHH Np/Cholesterol/Megalin -0.052 0.135 0.171 20.0 -0.229 75.0 95.0 SHH -0.107 0.148 -9999.0 0.0 -0.308 77.0 77.0 catabolic process 0.002 0.124 -9999.0 0.0 -0.303 27.0 27.0 SMO/Vitamin D3 -0.083 0.166 -9999.0 0.0 -0.396 28.0 28.0 SHH Np/Cholesterol/Hhip -0.122 0.156 -9999.0 0.0 -0.276 104.0 104.0 LRP2 0.066 0.097 0.269 40.0 -9999.0 0.0 40.0 receptor-mediated endocytosis -0.08 0.161 -9999.0 0.0 -0.423 22.0 22.0 SHH Np/Cholesterol/BOC -0.084 0.136 -9999.0 0.0 -0.253 83.0 83.0 SHH Np/Cholesterol/CDO -0.097 0.139 -9999.0 0.0 -0.252 94.0 94.0 mesenchymal cell differentiation 0.122 0.155 0.274 104.0 -9999.0 0.0 104.0 mol:Vitamin D3 -0.073 0.148 -9999.0 0.0 -0.313 32.0 32.0 IHH N/PTCH2 0.025 0.113 0.228 1.0 -0.32 16.0 17.0 CDON -0.027 0.144 -9999.0 0.0 -0.43 25.0 25.0 IHH N/PTCH1 0.019 0.138 -9999.0 0.0 -0.305 27.0 27.0 Megalin/LRPAP1 0.065 0.066 0.205 39.0 -9999.0 0.0 39.0 PTCH2 0.001 0.104 -9999.0 0.0 -0.43 12.0 12.0 SHH Np/Cholesterol -0.074 0.117 -9999.0 0.0 -0.233 77.0 77.0 PTCH1 0.002 0.124 -9999.0 0.0 -0.304 27.0 27.0 HHIP -0.079 0.187 0.269 1.0 -0.43 48.0 49.0