Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.042 -9999.0 0.0 -0.214 7.0 7.0 epithelial cell differentiation 0.041 0.051 -9999.0 0.0 -0.222 7.0 7.0 CYFIP2 0.015 0.068 -9999.0 0.0 -0.43 5.0 5.0 ENAH 0.012 0.09 0.283 13.0 -0.276 1.0 14.0 EGFR 0.014 0.068 -9999.0 0.0 -0.43 5.0 5.0 EPHA2 0.022 0.043 -9999.0 0.0 -0.43 2.0 2.0 MYO6 -0.005 0.066 0.187 16.0 -0.216 7.0 23.0 CTNNB1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.049 -9999.0 0.0 -0.257 5.0 5.0 AQP5 0.012 0.057 -9999.0 0.0 -0.274 1.0 1.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.006 0.06 0.174 15.0 -0.213 7.0 22.0 regulation of calcium-dependent cell-cell adhesion -0.001 0.077 0.196 15.0 -0.211 10.0 25.0 EGF 0.036 0.06 0.269 13.0 -9999.0 0.0 13.0 NCKAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.083 0.186 -9999.0 0.0 -0.458 37.0 37.0 cortical microtubule organization 0.041 0.051 -9999.0 0.0 -0.222 7.0 7.0 GO:0000145 -0.007 0.057 0.162 15.0 -0.203 7.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.046 0.053 -9999.0 0.0 -0.224 7.0 7.0 MLLT4 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.023 0.037 -9999.0 0.0 -0.229 6.0 6.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.039 -9999.0 0.0 -0.239 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.004 0.057 0.345 1.0 -0.221 1.0 2.0 PVRL2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.006 0.067 0.187 16.0 -0.214 8.0 24.0 ARF6/GTP 0.062 0.04 -9999.0 0.0 -0.225 1.0 1.0 CDH1 0.011 0.08 -9999.0 0.0 -0.43 7.0 7.0 EGFR/EGFR/EGF/EGF 0.031 0.066 -9999.0 0.0 -0.226 11.0 11.0 RhoA/GDP 0.042 0.051 -9999.0 0.0 -0.214 7.0 7.0 actin cytoskeleton organization -0.006 0.062 0.174 15.0 -0.215 7.0 22.0 IGF-1R heterotetramer 0.024 0.031 -9999.0 0.0 -0.429 1.0 1.0 GIT1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.024 0.031 -9999.0 0.0 -0.43 1.0 1.0 IGF1 -0.173 0.226 -9999.0 0.0 -0.43 96.0 96.0 DIAPH1 0.011 0.147 -9999.0 0.0 -0.522 14.0 14.0 Wnt receptor signaling pathway -0.041 0.051 0.222 7.0 -9999.0 0.0 7.0 RHOA 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.023 0.038 -9999.0 0.0 -0.231 6.0 6.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.007 0.062 0.337 1.0 -0.219 7.0 8.0 EFNA1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.009 0.06 0.18 13.0 -0.209 7.0 20.0 Ephrin A1/EPHA2 0.033 0.053 -9999.0 0.0 -0.243 6.0 6.0 SEC6/SEC8 -0.02 0.03 -9999.0 0.0 -0.206 5.0 5.0 MGAT3 -0.001 0.078 0.197 15.0 -0.214 10.0 25.0 HGF/MET -0.018 0.113 -9999.0 0.0 -0.211 54.0 54.0 HGF -0.074 0.2 0.269 6.0 -0.43 51.0 57.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.042 -9999.0 0.0 -0.215 7.0 7.0 actin cable formation 0.036 0.096 0.289 15.0 -0.236 1.0 16.0 KIAA1543 -0.006 0.066 0.174 16.0 -0.233 7.0 23.0 KIFC3 -0.007 0.063 0.188 14.0 -0.216 7.0 21.0 NCK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.005 0.066 0.351 1.0 -0.216 7.0 8.0 NCK1/GIT1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.041 0.051 -9999.0 0.0 -0.222 7.0 7.0 EXOC4 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.005 0.063 0.351 1.0 -0.216 6.0 7.0 PIP5K1C -0.007 0.061 0.176 15.0 -0.216 7.0 22.0 LIMA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.017 0.101 0.303 14.0 -0.319 1.0 15.0 adherens junction assembly -0.003 0.077 0.272 1.0 -0.319 3.0 4.0 IGF-1R heterotetramer/IGF1 -0.072 0.128 -9999.0 0.0 -0.214 96.0 96.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.006 0.07 0.351 1.0 -0.244 7.0 8.0 mol:GTP 0.055 0.038 -9999.0 0.0 -0.238 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.026 0.106 0.346 11.0 -9999.0 0.0 11.0 cortical actin cytoskeleton stabilization 0.013 0.042 -9999.0 0.0 -0.214 7.0 7.0 regulation of cell-cell adhesion -0.006 0.062 0.174 15.0 -0.215 7.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.042 -9999.0 0.0 -0.215 7.0 7.0