Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.011 0.058 -9999.0 0.0 -0.328 33.0 33.0 epithelial cell differentiation -0.014 0.079 -9999.0 0.0 -0.45 32.0 32.0 CYFIP2 -0.011 0.068 -9999.0 0.0 -0.35 32.0 32.0 ENAH 0.056 0.063 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.3 0.387 -9999.0 0.0 -0.796 384.0 384.0 EPHA2 -0.005 0.061 -9999.0 0.0 -0.802 6.0 6.0 MYO6 -0.014 0.076 -9999.0 0.0 -0.426 33.0 33.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.006 0.04 -9999.0 0.0 -0.529 4.0 4.0 AQP5 -0.239 0.296 -9999.0 0.0 -0.595 405.0 405.0 CTNND1 -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.073 -9999.0 0.0 -0.419 32.0 32.0 regulation of calcium-dependent cell-cell adhesion -0.036 0.119 -9999.0 0.0 -0.429 84.0 84.0 EGF -0.167 0.326 -9999.0 0.0 -0.797 214.0 214.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.039 0.141 -9999.0 0.0 -0.574 54.0 54.0 cortical microtubule organization -0.014 0.079 -9999.0 0.0 -0.45 32.0 32.0 GO:0000145 0.024 0.076 -9999.0 0.0 -0.4 32.0 32.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.014 0.079 -9999.0 0.0 -0.455 32.0 32.0 MLLT4 -0.005 0.062 -9999.0 0.0 -0.728 7.0 7.0 ARF6/GDP -0.013 0.066 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.003 0.038 -9999.0 0.0 -0.48 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.034 0.08 -9999.0 0.0 -0.391 32.0 32.0 PVRL2 -0.001 0.013 -9999.0 0.0 -0.286 2.0 2.0 ZYX -0.013 0.074 -9999.0 0.0 -0.426 32.0 32.0 ARF6/GTP -0.003 0.034 -9999.0 0.0 -0.441 6.0 6.0 CDH1 -0.025 0.14 -9999.0 0.0 -0.802 32.0 32.0 EGFR/EGFR/EGF/EGF -0.253 0.266 -9999.0 0.0 -0.479 538.0 538.0 RhoA/GDP -0.013 0.073 -9999.0 0.0 -0.421 32.0 32.0 actin cytoskeleton organization 0.03 0.079 -9999.0 0.0 -0.401 33.0 33.0 IGF-1R heterotetramer -0.021 0.12 -9999.0 0.0 -0.609 35.0 35.0 GIT1 -0.001 0.02 -9999.0 0.0 -0.286 5.0 5.0 IGF1R -0.021 0.12 -9999.0 0.0 -0.61 35.0 35.0 IGF1 -0.177 0.333 -9999.0 0.0 -0.802 225.0 225.0 DIAPH1 -0.002 0.045 -9999.0 0.0 -0.699 4.0 4.0 Wnt receptor signaling pathway 0.014 0.079 0.45 32.0 -9999.0 0.0 32.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.013 0.067 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.03 0.081 -9999.0 0.0 -0.411 33.0 33.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.029 0.086 -9999.0 0.0 -0.402 39.0 39.0 Ephrin A1/EPHA2 -0.015 0.077 -9999.0 0.0 -0.407 38.0 38.0 SEC6/SEC8 -0.014 0.073 -9999.0 0.0 -0.761 1.0 1.0 MGAT3 -0.036 0.121 -9999.0 0.0 -0.437 84.0 84.0 HGF/MET -0.109 0.207 -9999.0 0.0 -0.461 241.0 241.0 HGF -0.053 0.199 -9999.0 0.0 -0.802 67.0 67.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.011 0.058 -9999.0 0.0 -0.33 33.0 33.0 actin cable formation 0.07 0.061 -9999.0 0.0 -0.327 1.0 1.0 KIAA1543 0.03 0.09 -9999.0 0.0 -0.436 33.0 33.0 KIFC3 -0.014 0.077 -9999.0 0.0 -0.427 34.0 34.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.014 0.076 -9999.0 0.0 -0.426 33.0 33.0 NCK1/GIT1 -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.014 0.079 -9999.0 0.0 -0.45 32.0 32.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.074 -9999.0 0.0 -0.426 32.0 32.0 PIP5K1C -0.013 0.074 -9999.0 0.0 -0.426 32.0 32.0 LIMA1 -0.001 0.025 -9999.0 0.0 -0.802 1.0 1.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.012 0.059 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.046 0.086 -9999.0 0.0 -0.643 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.114 0.2 -9999.0 0.0 -0.442 261.0 261.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.004 0.048 -9999.0 0.0 -0.613 6.0 6.0 MET -0.134 0.299 -9999.0 0.0 -0.799 171.0 171.0 PLEKHA7 -0.014 0.081 -9999.0 0.0 -0.454 32.0 32.0 mol:GTP -0.003 0.037 -9999.0 0.0 -0.476 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.013 0.069 -9999.0 0.0 -0.715 1.0 1.0 cortical actin cytoskeleton stabilization -0.011 0.058 -9999.0 0.0 -0.328 33.0 33.0 regulation of cell-cell adhesion 0.03 0.079 -9999.0 0.0 -0.401 33.0 33.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.011 0.058 -9999.0 0.0 -0.33 33.0 33.0