Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.011 0.047 -9999.0 0.0 -0.262 23.0 23.0 epithelial cell differentiation 0.035 0.059 -9999.0 0.0 -0.316 22.0 22.0 CYFIP2 0.029 0.051 0.262 27.0 -0.576 3.0 30.0 ENAH -0.004 0.06 0.294 10.0 -9999.0 0.0 10.0 EGFR -0.193 0.288 -9999.0 0.0 -0.576 362.0 362.0 EPHA2 0.02 0.043 -9999.0 0.0 -0.576 5.0 5.0 MYO6 -0.013 0.054 0.361 1.0 -0.306 23.0 24.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.036 -9999.0 0.0 -0.368 3.0 3.0 AQP5 -0.189 0.262 0.333 1.0 -0.503 396.0 397.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.053 0.358 1.0 -0.301 22.0 23.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.078 0.358 1.0 -0.305 61.0 62.0 EGF -0.093 0.238 0.262 2.0 -0.576 195.0 197.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.016 0.117 0.29 1.0 -0.461 50.0 51.0 cortical microtubule organization 0.035 0.059 -9999.0 0.0 -0.316 22.0 22.0 GO:0000145 -0.013 0.05 0.351 1.0 -0.288 22.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.039 0.06 -9999.0 0.0 -0.319 22.0 22.0 MLLT4 0.021 0.034 0.262 1.0 -0.576 3.0 4.0 ARF6/GDP -0.021 0.041 -9999.0 0.0 -0.282 3.0 3.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.045 0.039 -9999.0 0.0 -0.335 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.003 0.052 -9999.0 0.0 -0.286 22.0 22.0 PVRL2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.013 0.053 0.361 1.0 -0.305 22.0 23.0 ARF6/GTP 0.049 0.041 -9999.0 0.0 -0.314 5.0 5.0 CDH1 0.008 0.088 -9999.0 0.0 -0.576 22.0 22.0 EGFR/EGFR/EGF/EGF -0.151 0.202 -9999.0 0.0 -0.339 497.0 497.0 RhoA/GDP 0.036 0.057 -9999.0 0.0 -0.303 22.0 22.0 actin cytoskeleton organization -0.015 0.051 0.343 1.0 -0.298 23.0 24.0 IGF-1R heterotetramer 0.012 0.083 0.261 2.0 -0.575 19.0 21.0 GIT1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.083 0.262 2.0 -0.576 19.0 21.0 IGF1 -0.102 0.245 -9999.0 0.0 -0.576 211.0 211.0 DIAPH1 0.026 0.102 -9999.0 0.0 -0.555 15.0 15.0 Wnt receptor signaling pathway -0.035 0.059 0.316 22.0 -9999.0 0.0 22.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.021 0.041 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.015 0.052 0.346 1.0 -0.304 23.0 24.0 EFNA1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.017 0.055 -9999.0 0.0 -0.295 28.0 28.0 Ephrin A1/EPHA2 0.024 0.056 -9999.0 0.0 -0.298 22.0 22.0 SEC6/SEC8 -0.023 0.045 -9999.0 0.0 -0.299 23.0 23.0 MGAT3 -0.025 0.079 0.361 1.0 -0.309 61.0 62.0 HGF/MET -0.04 0.156 -9999.0 0.0 -0.326 214.0 214.0 HGF -0.011 0.141 -9999.0 0.0 -0.576 59.0 59.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.011 0.047 -9999.0 0.0 -0.264 23.0 23.0 actin cable formation 0.04 0.096 0.309 37.0 -0.293 1.0 38.0 KIAA1543 -0.014 0.055 0.354 1.0 -0.316 22.0 23.0 KIFC3 -0.014 0.052 0.361 1.0 -0.306 22.0 23.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.014 0.052 -9999.0 0.0 -0.306 22.0 22.0 NCK1/GIT1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.035 0.059 -9999.0 0.0 -0.316 22.0 22.0 EXOC4 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.051 0.361 1.0 -0.306 20.0 21.0 PIP5K1C -0.013 0.054 0.361 1.0 -0.306 22.0 23.0 LIMA1 0.024 0.019 -9999.0 0.0 -0.576 1.0 1.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.016 0.089 0.305 24.0 -9999.0 0.0 24.0 adherens junction assembly -0.023 0.102 0.298 3.0 -0.632 14.0 17.0 IGF-1R heterotetramer/IGF1 -0.043 0.151 -9999.0 0.0 -0.314 222.0 222.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.03 0.199 1.0 -0.302 6.0 7.0 MET -0.071 0.219 -9999.0 0.0 -0.576 159.0 159.0 PLEKHA7 -0.014 0.058 0.361 1.0 -0.331 22.0 23.0 mol:GTP 0.043 0.038 -9999.0 0.0 -0.333 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.01 0.068 0.373 6.0 -0.523 1.0 7.0 cortical actin cytoskeleton stabilization 0.011 0.047 -9999.0 0.0 -0.262 23.0 23.0 regulation of cell-cell adhesion -0.015 0.051 0.343 1.0 -0.298 23.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.011 0.047 -9999.0 0.0 -0.264 23.0 23.0